PRINCIPAL INVESTIGATOR/PROGRAM DIRECTOR (Last, first, middle):
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel in the order listed for Form Page 2.
Follow the sample format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
NOTE: The Biographical Sketch may not exceed four pages. Items A and B (together) may not exceed two of
the four-page limit. Follow the formats and instructions on the attached sample.
A. Positions and Honors. List in chronological order previous positions, concluding with your present position. List
any honors. Include present membership on any Federal Government public advisory committee.
B. Selected peer-reviewed publications (in chronological order). Do not include publications submitted or in
preparation.
C. Research Support. List selected ongoing or completed (during the last three years) research projects (federal
and non-federal support). Begin with the projects that are most relevant to the research proposed in this
application. Briefly indicate the overall goals of the projects and your role (e.g. PI, Co-Investigator, Consultant) in
the research project. List award amounts and percent effort in projects.
For each project, please use this format:
Role (e.g., PI, Co-Investigator):
Name and Duration (exact dates) of grant (ongoing or completed in the last three years):
Award Amount (total direct $):
One line description of research that grant will cover:
In addition, list also:
Other funds available to find student’s project?:
Who have you mentored in the past five years?:
SAMPLE BIOSKETCH FOLLOWS ON NEXT PAGE.
Mentors/biosketchsample.doc
Provide the following information for the key personnel in the order listed for Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Claude A. Piantadosi, M.D.
Professor of Medicine
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
University of North Carolina at Chapel Hill, N.C.
Johns Hopkins University School of Medicine,
Baltimore, M.D.
DEGREE
(if applicable)
YEAR(s)
B.A.
M.D.
1971
1975
FIELD OF STUDY
Chemistry/ Zoology
Medicine
Professional Experience
1975 - 1976
1976 - 1977
1977 - 1980
1980 - 1981
1981 - 1987
1982 - 1988
1984 - 1990
1988 - 1994
1990 - Date
1994 - Date
Intern, Osler Medical Service, Johns Hopkins Hospital, Baltimore, MD
Assistant Resident, Osler Medical Service, Johns Hopkins Hospital, Baltimore, MD
Diving and Submarine Medical Officer, New London, CT and Assistant Medical Research
Officer, U.S. Navy Experimental Diving Unit, Panama City, FL
Clinical Fellow, Division of Allergy, Critical Care and Respiratory Medicine, Dept of
Medicine, Duke University Medical Center, Durham, NC
Research Associate, Dept of Physiology, Duke University Medicine Center, Durham, NC
Assistant Professor of Medicine, Duke University Medical Center, Durham, NC
Director, Medical Intensive Care Unit, Durham VA Medical Center, Durham, NC
Associate Professor of Medicine, Duke University Medical Center, Durham, NC
Director, Center for Hyperbaric Medicine and Environmental Physiology and Assistant
Professor of Anesthesiology, Duke University Medical Center, Durham, NC
Professor of Medicine, Duke University Medical Center, Durham, NC
Honors and Awards
1970
Phi Beta Kappa, University of North Carolina
1974
Henry Strong Denison Research Scholar, Johns Hopkins University
1975
Johns Hopkins Medical Society Student Research Award
1977
US Navy Surgeon General’s Award in Diving and Submarine Medicine
1980
US Navy Commendation Medal
1992
American Society for Clinical Investigation
2003
Association of American Physicians
Laboratory-Based Research Projects Ongoing or Completed During the Last 3 Years
Dr. Piantadosi's research work focuses on regulation of oxidative metabolism, oxidative stress, and nitric oxide/
carbon monoxide biology in the lung and other tissues. A portion of the work is devoted to understanding the
roles of oxidative and nitrosative stress during acute lung injury, produced experimentally by exposure to
oxygen, endotoxin, or other inflammatory mediators. The physiological, biochemical and molecular responses
of the lung are measured during the evolution of oxidative stress in order to better understand the
pathogenesis of the injury and thereby be able to prevent it with specific interventions. A second aspect of the
work is devoted to understanding how non-pulmonary organs respond to acute lung injury produced by
endotoxemia and sepsis. The working hypothesis is focused on the role of mitochondrial dysfunction in energy
provision and initiation of programmed cell death (apoptosis) as causes of organ failure.
Representative Publications (Selected from 170 peer-reviewed papers)
Brown SD and CA Piantadosi. Recovery of energy metabolism in rat brain after carbon monoxide hypoxia. J.
Clin. Invest. 89:666-672, 1992.
Zhang J and CA Piantadosi. Mitochondrial oxidative stress after CO hypoxia in the rat brain. J. Clin. Invest.
90:1193- 1199, 1992.
Mentors/biosketchsample.doc
Todd NW, TP Kennedy, CM Hunt, CA Piantadosi and AR Whorton. Effects of inhibition and induction of
cytochrome P450 isoenzymes on hyperoxic lung injury in rats. Am. J. Resp. Cell Mol. Biol. 7:222-229, 1992.
Oury TD, YS Ho, CA Piantadosi and JD Crapo. Extracellular superoxide dismutase, nitric oxide and central
nervous system O2 toxicity. Proc. Nat. Acad. Sci., USA 89: 9715-9719, 1992.
Parsons WJ, JC Rembert, RP Bauman, FG Duhaylongsod, JC Greenfield, Jr and CA Piantadosi. Myocardial
oxygenation in dogs during partial and complete coronary artery occlusion. Circ. Research 73:458-464, 1993.
Oury TD, CA Piantadosi and JD Crapo. Cold-induced brain edema in mice. Role of nitric oxide. J. Biol.
Chem. 268:15394-15398, 1993.
Taylor DE, AJ Ghio and CA Piantadosi. Reactive oxygen species produced by liver mitochondria of septic
rats. Arch Biochem. Biophys. 316(1):70-76, 1995.
Piantadosi, CA and J Zhang. Mitochondrial generation of reactive oxygen species after brain ischemia in the
rat. Stroke 27:327-332, 1996.
Stamler JS, L Jia, IT Demchenko, J Eu, TJ McMahon and CA Piantadosi. Blood flow regulation by snitrosohemoglobin in the physiological oxygen gradient. Science 276:1937-2092, 1997.
Kantrow SP, DE Taylor, MS Carraway and CA Piantadosi. Oxidative metabolism in rat hepatocytes and
mitochondria during sepsis. Arch. Biochem. Biophys., 345(2):278-288, 1997.
Piantadosi CA, J Zhang, ED Levin, RJ Folz and DE Schmechel. Apoptosis and delayed neuronal damage
after carbon monoxide poisoning in the rat. Exper. Neurol., 147:103-114, 1997.
Taylor, JT, MS Carraway and CA Piantadosi. Lung specific induction of heme oxygenase-1 and hyperoxic
lung injury. Am. J. Physiol. (Lung Cell Mol. Physiol.), 247(18):L582-592, 1998.
Taylor, D.E., S.P. Kantrow and C.A. Piantadosi. Mitochondrial respiration after sepsis and prolonged hypoxia.
Am. J. Physiol. (Lung Cell Mol. Physiol.), 275:L139-L144, 1998.
Carraway MS, AJ Ghio, JL Taylor and CA Piantadosi. Induction of ferritin and heme oxygenase-1 by
endotoxin in the lung. Am. J. Physiol (Lung Cell Mol. Physiol.) 275: L582-592, 1998.
Kantrow SP, LG Tatro and CA Piantadosi. Oxidative stress and adenine nucleotide control of mitochondrial
permeability transition. Free Radical Biol. Med., 28 (2):251-260, 2000.
Carraway, MS, AJ Ghio, CA Piantadosi. Heme oxygenase and adaptation of the lung to hypoxia. Am. J.
Physiol. (Lung Cell Mol Physiol.),278:L806-L812, 2000.
Clayton CE, MS Carraway, HB Suliman, ED Thalmann, KN Thalmann, DE Schmechel and CA Piantadosi.
Inhaled carbon monoxide and hyperoxic lung injury in rats. Am. J. Physiol. (Lung Cell Mol. Physiol.),
281:L949-L957, 2001.
Piantadosi, CA, L G Tatro and AR Whorton. Nitric oxide and differential effects of ATP on mitochondrial
permeability transition. Arch. Biochem. Biophys. Part B. Nitric Oxide Biol. and Chem., 6: 45-60, 2001.
Suliman, HB. MS Carraway, LW. Velsor, BJ Day, AJ Ghio and CA. Piantadosi., Rapid mtDNA deletion by
oxidants in rat liver mitochondria after hemin exposure, Free Radical Biol. Med., 32; 3:246-256, 2002.
Carraway MS, AJ Ghio, J Carter, CA Piantadosi. Carbon monoxide promotes hypoxic pulmonary vascular
remodeling. Am. J. Physiol. (Lung Cell Mol Physiol), 282:L693-L702, 2002.
Yang, FM, X Wang, DJ Haile, CA Piantadosi and AJ Ghio. Iron increases the expression of iron export
protein MTP1 in lung cells, Am. J. Physiol. (Lung Cell Mol Physiol), 283(5): L932-39, 2002.
McMahon TJ, RE Moon, MS Carraway, AE Stone, BW Stolp, AJ Gow, P Watke, CA Piantadosi and JS
Stamler, Nitric oxide in the human respiratory cycle. Nature Med., 8 (7): 711-717, 2002.
Demchenko, IT TD Oury, JD Crapo and CA Piantadosi. Regulation of the cerebrovascular response to
oxygen, Circ. Research, 91;1031-1037, 2002.
Allen BW, LA Coury, Jr and CA Piantadosi. Electrochemical detection of physiological nitric oxide: Materials
and methods, Methods Enzymol., (Vol. 359) Nitric Oxide, Part D: Nitric Oxide Detection, Mitochondria and Cell
Functions, and Peroxynitrite Reactions. Cadenas, E, L Packer (Eds.) San Diego: Academic Press, pp. 125134, 2002.
Carraway MS, Welty-Wolf, KE, DL Miller, S Idell, TL Ortel, L Petersen and CA Piantadosi. Blockade of tissue
factor: treatment for organ injury in established sepsis. Am. J. Respir. Crit. Care Med., 167:1200-1209, 2003.
Suliman HB, MS Carraway and CA Piantadosi. Post-lipopolysaccharide oxidative damage of mtDNA. Am. J.
Respir. Crit. Care Med., 167: 570-579, 2003.
Ghio AJ, EN Grayck, J Turi, I Jaspers, DR Mercatante, R Kole, and CA Piantadosi. Superoxide-dependent
iron uptake: A new role for anion exchange protein-2, Am. J. Resp. Cell Mol. Biol., 29:653-660, 2003.
Suliman, HB, MS Carraway, KE Welty-Wolf, AR Whorton, and CA Piantadosi. LPS stimulates mitochondrial
biogenesis via activation of nuclear respiratory factor-1. J. Biol. Chem., 278: 41510-41518, 2003.
Mentors/biosketchsample.doc
C. Research Support (Use format as shown above)
NIH PO1 HL 31992-15
04/01/99-3/31/05
NIH/NHLBI
$325,400 (annual)
Project 1: Coagulation in Acute Lung Injury (Project Leader: Claude A. Piantadosi)
Primate Studies Core (Core Director: Claude A. Piantadosi, M.D.)
Major goal: To assess specific roles for pro-inflammatory cytokines in the pathogenesis of pulmonary
and other organ dysfunction in sepsis and acute lung injury in primates and determine if tissue injury can
be ameliorated by coagulation blockade directed at these effects. The current application is intended to
replace this Project and Core in its entirety.
NIH PO1 HL 42444-10 (PI: Claude A.
Piantadosi)
NIH/NHLBI
Toxic and Therapeutic Effects of Oxygen
7/1/2000- 6/30/05
$1,339,503 (five years)
Major goal: To better understand oxidative/nitrosative stress in the lungs and other organs generated by
CO and NO and determine their relationships to changes in heme protein function, cell signaling, cell
proliferation and cell death in vitro and in vivo.
VA Merit Review (PI: Claude A. Piantadosi)
VA Medical Center
Respiration in Sepsis
10/1/03-9/30/08
$92,100 (annual)
Major goal: To understand the role of reactive nitrogen and oxygen species on mitochondrial gene
transcription, electron transport protein function and mitochondrial cell death signaling during sepsis.
ONR N00014011240 (PI: Claude A.
12/1/03-11/30/06
Piantadosi)
Office of Naval Research
$773,541(three years)
Nitric Oxide and CNS O2 toxicity: Biochemical modeling and risk prediction.
Major goal: This project is designed to assess oxidative and nitrosative stress in the brain of the rodent
during extreme hyperoxia. The data on oxidative/nitrosative stress are then used in a biochemical
model to predict risk of oxygen convulsions.
Mentors/biosketchsample.doc