Supplementary Table 5 | Studies of vitamin D in OA
Publication
(year)
Uitterlinden
et al.S46
(1997)
Lane et al.S47
(1999)
Study design
Exposure or
variable analysed
DNA
polymorphisms
Outcome
Main finding
OA Kellgren
score
Baseline serum
25(OH)D level
DNA
polymorphisms
Incident
radiographic
hip OA
Radiographic
OA
Retrospective cohort study
in 142 men with OA
DNA
polymorphism
(Taq1 in VDR)
MRI-detected
OA of the
lumbar spine
Solovieva
et al.S50
(2006)
Cross-sectional study in 295
dentists and 248 teachers
Apa1 and Taq1
polymorphism at
VDR
Radiographic
hand OA
Felson
et al.S51
(2007)
2 prospective cohort
studies; 715 (Framingham)
and 277 (Boston)
individuals with OA
Prospective/cross-sectional
cohort study; 880 patients
with OA at baseline, 353 of
whom were studied again
2.9 years later
Prospective cohort study;
728 women and 520 men
with OA
Baseline serum
25(OH)D level
Progression of
radiographic
knee OA over
9 years
MRI–detected
and
radiographic
knee OA
One VDR haplotype overrepresented in OA
osteophytes
Low serum 25(OH)D
associated with
increased JSN
No association between
VDR polymorphisms and
OA at hand, hip or knee
Prevalence of disc bulges
and osteophytes lower
for tt genotype than TT
genotype
Carriers of the t allele or
At haplotype reduced
odds hand OA compared
with carriers of the T
allele or non-At
haplotype
No association between
25(OH)D and OA
progression
Huang
et al.S48
(2000)
Videman
et al.S49
(2001)
Cross-sectional study; 270
female patients with OA
Prospective cohort study;
1,104 elderly men with OA
Baseline serum
25(OH)D level
Radiographic
knee OA at
baseline and
6.5 year followup
Radiographic
hip OA
Cross-sectional study; 787
individuals with knee pain
and radiographic OA
Polymorphism in
VDR and serum
25(OH)D level
Knee pain and
radiographic
OA
Ding et al.S52
(2009)
Bergink
et al.S53
(2009)
Chaganti
et al.S54
(2010)
Muraki
et al.S55
(2011)
arcOGEN
consortiumS56
(2012)
Population-based cohort
study; 846 individuals with
OA
Prospective cohort study;
237 individuals
Baseline serum
25(OH)D level
Baseline dietary
vitamin D intake
Continuous inverse
association between
baseline 25(OH)D level
and cartilage volume and
loss
Inverse association
between 25(OH)D level
and progression of knee
OA
Inverse association
between 25(OH)D level
and hip OA
Weak inverse
association between
25(OH)D level and knee
pain
5 loci vitamin-Dassociated related to OA
identified
Case–control study; 7,410
Genome-wide
Severe OA
patients with severe OA and association study
11,009 control individuals
from the UK.
Replication study in 7,473
cases and 42,938 controls
from Europe
Abbreviations: 25(OH)D, 25-hydroxyvitamin D; JSN, joint-space narrowing; OA, osteoarthritis.
S46.
Uitterlinden, A. G. et al. Vitamin D receptor genotype is associated with radiographic osteoarthritis
at the knee. J. Clin. Invest. 100, 259–263 (1997).
S47.
Lane, N. E. et al. Serum vitamin D levels and incident changes of radiographic hip osteoarthritis: a
longitudinal study. Study of Osteoporotic Fractures Research Group. Arthritis Rheum. 42, 854–860
(1999).
S48.
Huang, J., Ushiyama, T., Inoue, K., Kawasaki, T. & Hukuda, S. Vitamin D receptor gene polymorphisms
and osteoarthritis of the hand, hip, and knee: a case–control study in Japan. Rheumatology (Oxford) 39,
79–84 (2000).
S49.
Videman, T. et al. The relative roles of intragenic polymorphisms of the vitamin d receptor gene in
lumbar spine degeneration and bone density. Spine (Phila. Pa. 1976) 26, E7–E12 (2001).
S50.
Solovieva, S. et al. Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis
in Finnish women. Arthritis Res. Ther. 8, R20 (2006).
S51.
Felson, D. T. et al. Low levels of vitamin D and worsening of knee osteoarthritis: results of two
longitudinal studies. Arthritis Rheum. 56, 129–136 (2007).
S52.
Ding, C. et al. Serum levels of vitamin D, sunlight exposure, and knee cartilage loss in older adults:
the Tasmanian older adult cohort study. Arthritis Rheum. 60, 1381–1389 (2009).
S53.
Bergink, A. P. et al. Vitamin D status, bone mineral density, and the development of radiographic
osteoarthritis of the knee: the Rotterdam Study. J. Clin. Rheumatol. 15, 230–237 (2009).
S54.
Chaganti, R. K. et al. Association of 25-hydroxyvitamin D with prevalent osteoarthritis of the hip in
elderly men: the osteoporotic fractures in men study. Arthritis Rheum. 62, 511–514 (2010).
S55.
Muraki, S. et al. Association of vitamin D status with knee pain and radiographic knee osteoarthritis.
Osteoarthritis Cartilage 19, 1301–1306 (2011).
S56.
arcOGEN Constorium and arcOGEN Collaborators. Identification of new susceptibility loci for
osteoarthritis (arcOGEN): a genome-wide association study. Lancet 380, 815–823 (2012).