16TH NOVEMBER 2003 GENETICS, GENOMICS, PROTEOMICS AND BIOINFORMATICS VOLUME EDITORS Lynn B. Jorde University of Utah, USA Peter Little University of New South Wales, Australia Michael Dunn Kings College London, UK Shankar Subramaniam University of California at San Diego, USA INSTRUCTIONS FOR CONTRIBUTORS John Wiley & Sons Publishing Editor Editorial Coordinator Joan Marsh Life & Medical Sciences John Wiley & Sons Ltd International House Ealing Broadway London W5 5DB, UK Tel: +44 (0) 208 326 3846 Fax: +44 (0) 208 326 3801 E-mail:jmarsh@wiley.co.uk Layla Paggetti Major Reference Works John Wiley & Sons The Atrium, Southern Gate Chichester West Sussex PO19 8SQ, UK Tel: +44 (0)1243 770 427 Fax: +44 (0)1243 770 154 E-mail:ggpb@wiley.co.uk All correspondence re. the subject matter of your contribution should be directed to your Section Editor in the first instance, and to the Publishing Editor should this require further clarification. All correspondence in connection with details of manuscript preparation, proofs or related matters should be addressed to the Editorial Coordinator Reference Work Home page www.wiley.com/ggpb 2 CONTENTS 1 2 Purpose and scope of the Reference Work ............................................................................................ 3 Submission of manuscripts .................................................................................................................... 4 2.1 Presentation ....................................................................................................................................... 4 2.2 Preparation of the electronic manuscript ........................................................................................... 4 2.3 Draft submission of manuscripts ....................................................................................................... 4 2.4 Final submission of manuscripts ....................................................................................................... 4 3 Due date ................................................................................................................................................. 5 4 Unique article numbers (unique id) ....................................................................................................... 5 5 Structure of the Reference Work ........................................................................................................... 5 6 Structure of articles ................................................................................................................................ 6 7 Article title ............................................................................................................................................. 6 8 Contributor name ................................................................................................................................... 7 9 Basic affiliation...................................................................................................................................... 7 10 Keywords ............................................................................................................................................... 7 11 Abstract .................................................................................................................................................. 8 12 Main text ................................................................................................................................................ 8 12.1 Nucleic acid sequences ................................................................................................................. 8 12.2 Gene and protein nomenclature .................................................................................................... 8 12.3 Genus and species names .............................................................................................................. 8 12.4 Enzymes ........................................................................................................................................ 8 12.5 Chemical schemes, structures and equations ................................................................................ 8 12.6 Mathematical equations ................................................................................................................ 9 12.7 CAS Registry numbers ................................................................................................................ 10 12.8 Chemical nomenclature and mathematical notation ................................................................... 10 13 Spelling and editorial style .................................................................................................................. 10 14 Symbols and units ................................................................................................................................ 10 15 Abbreviations and acronymns ............................................................................................................. 11 16 Related articles..................................................................................................................................... 11 17 Biblographic references ....................................................................................................................... 11 18 Further reading..................................................................................................................................... 12 19 Tables and captions.............................................................................................................................. 12 20 Figures and captions ............................................................................................................................ 12 21 Cross reference strategy ....................................................................................................................... 14 22 Copyright, trademark and permissions ................................................................................................ 15 23 The production process ........................................................................................................................ 15 23.1 Project management .................................................................................................................... 15 23.2 Copy editing ................................................................................................................................ 16 1.3 Proofreading .................................................................................................................................... 16 1 Purpose and scope of the Reference Work This four-volume, 2000-page reference work will be an important publication in the rapidly developing fields of genomics and proteomics, plus bioinformatics and genetics relating to these disciplines. The major focus will be on the human genome and proteome, with special reference to pharmacogenomics, as well as animal models and important human pathogens. The Genetics, Genomics, Proteomics and Bioinformatics will provide information concerning the principles and practice of genetics and genomics, proteomics and associated bioinformatics for newcomers and those already working in these fields. It will act as a reference source, providing facts and 3 explanations of basic concepts in these subjects in a clear, readily assimilated format. It will also include specialist review articles covering new products, techniques and developments. Cross-linking within the online edition will allow readers to follow leads easily from one subject to another, emphasising the interdependence of these multidisciplinary fields. This major reference work will present information derived from the genome sequences of humans and model organisms, as well as those of important pathogens, that will improve our understanding of gene organization and function in these organisms. It will describe studies of the protein complements of cells in different organisms under different conditions, their interactions and their assembly into pathways, using both experimental and theoretical approaches. The Bioinformatics volume will explain computational methods for studying both the genomic and protein make-up of organisms via novel experimental techniques or by analysis of pre-existing data. 2 2.1 Submission of manuscripts Presentation Manuscripts should be typed (in at least 12 point size) on one side of paper (A4 or 8.5" 11” size) with double spacing between all lines of text, tables, figure captions, and references. There should be reasonable margins (at least 2.5 cm) at the top, bottom, and left- and right-hand sides. All pages should be numbered consecutively in the top right-hand corner; this includes pages containing references, tables, figure captions and figures, which should be grouped in that order after the text pages. There will be approximately 700 words (or the equivalent in tabular or illustrative material) on the final printed page. An average double-spaced manuscript page, in 12-point Times Roman font, typically contains about 250 words. Thus, one printed page equates to approximately three double-spaced A4 manuscript pages. 2.2 Preparation of the electronic manuscript If you are preparing your material on a PC, Macintosh, or workstation, then please use a standard word processing program, preferably Word or Word Perfect. Please do not use layout programs such as Latex, Quark Xpress, FrameMaker or PageMaker. 2.3 Draft submission of manuscripts Please send one copy of your complete manuscript directly to the Editorial Coordinator by the contracted due date. If you are able to transfer your manuscript to the Editorial Coordinator via the Internet please do this at the time of sending the hard copy (email: ggpb@wiley.co.uk). If you only have hard copies of figures, please just send a copy by fax at this stage. If possible, please compress any files larger than 1Mb using a standard compression tool, e.g. WinZip. The Editorial Coordinator will forward your manuscript to the Section Editor for review. The Section Editor will check your contribution and, assuming it is acceptable, you will subsequently receive from the Section Editor a list of requested and suggested changes. 2.4 Final submission of manuscripts PLEASE NOTE: This is only required in cases where the Section Editor indicates to you that you need to make changes to the article. Within 4 weeks of receipt of the Section Editor’s review comments, you should email the revised, final version of your manuscript to the Editorial Coordinator (ggpb@wiley.co.uk) and send in any hard copy figures and permissions documentation. As a back up against file corruption during transfer or lost post etc, you must retain a copy of all the material you send. You will also need the copy of your material when you come to check proofs of your article. 4 Contributors who are unable to submit their final, revised manuscript to the Editorial Coordinator within 4 weeks of receiving the Section Editor’s comments should inform the Editorial Coordinator (ggpb@wiley.co.uk) at the earliest opportunity. The Editorial Coordinator will then forward your file to the Section Editor for final approval. When the Section Editor has indicated approval, the Editorial Coordinator will email you to confirm acceptance of your article for publication. Together with your manuscript and your permissions letters you must also supply a manifest document. The manifest should contain the following information: 1. 2. 3. 4. Your full name Your full contact address Your full telephone and fax numbers Your e-mail address If you are not taking on the role of the corresponding author, please give us full contact details of the contributor who is to perform that function. Any changes of address, telephone number, fax number and/or e-mail address, whether temporary or permanent, should be notified to the Section Editor and the Editorial Coordinator as soon as they are known, giving dates when they become effective and, if appropriate, cease to be effective. You should retain backed up copies of all electronic files that you submit to the Publisher. 3 3.1 Due date Initial and Final Due Dates Contributors must adhere to the due date specified in their contracts for submission of their initial manuscripts to the Editorial Coordinator. Contributors who are unable to meet the due date should inform the Section Editor at the earliest opportunity. Contributors should also adhere to the ‘4-week date’ set by the Section Editor immediately following review. Again, Contributors who are unable to meet the proposed final due date should inform the Editorial Coordinator at the earliest opportunity. 4 Unique article numbers (unique id) The Publisher will assign your article a unique identifying number. This number should be quoted in all correspondence with Wiley or the project manager assigned to manage this project on behalf of Wiley. The unique article number (unique id) is used when building cross reference links as described in Section 21 below. 5 Structure of the Reference Work The Encyclopedia will be organised to ensure maximum ease of use for its readers. Entries will be presented thematically, within Sections within four Volumes (Genetics, Genomics, Proteomics, Bioinformatics). Each volume will contain a full table of contents. The last volume will contain a subject index pertaining to the complete work. 5 The Encyclopedia will comprise five types of entry: 1. 2. 3. 4. 5. Introductory review Specialist review Short specialist review Basic techniques/tutorials entry Definition article entry It is envisaged that there will be approximately 50 introductory reviews, 150 specialist reviews, 200 short specialist reviews and 100 of the basic techniques/tutorials. These will be complemented by a glossary of about 550 definitions of between 50 and 100 words. Your contract will identify the type of article you have been commissioned to write and the Publisher’s expectations with regard to extent. Article types 1-4 will be written by the contributors. The definition articles will be written by a specialist writer. 6 Structure of articles Each article (types 1-3) will contain the majority of the following elements: 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. Article title Contributor name(s) Basic affiliation Keywords Abstract Introduction Main text Acknowledgments Related articles References Further Reading Tables and captions Figures and captions Schemes and captions Structures compulsory compulsory compulsory compulsory compulsory compulsory compulsory optional optional compulsory optional optional optional optional optional For the purpose of this list, the term ‘Main text’ includes maths and chemical equations, and chemical reactions. The elements of your article should be submitted in this order. Elements 1 through 12 can be contained in one text file. Elements 13, 14 and 15 must be contained in separate files (see Section 20 below for details). 7 Article title This should be the title agreed with the Section Editor and specified in the Contributor’s contract with the Publisher. Any material changes to this title, during the writing and review phases, must be approved by the Section Editor, Volume Editor and the Publisher. 6 Once an article enters the production process (i.e. has been transmitted in its final form to the Publisher) its title cannot be amended and any changes to the title made at proof stage will be ignored by the proofreader and typesetter. You should use sentence case to format the title. This means: Microarray design not Microarray Design The two exceptions to this usage are: 1. proper nouns (for example, Gel electrophoresis and Southern blotting) or 2. when particular letters have to be either upper or lower case, for example the term ‘pH’ can never be PH or ph. Where titles contain hyphenated words, the word after the hyphen begins with a lower case letter, e.g. Fluorophore-assisted light inactivation 8 Contributor name Please include your name, and the names of all other contributors to your article, beneath the title of the article. Please supply your name in the following format: Full christian name, middle initital(s), full family name, e.g. John A. Smith Please include the full point after the middle initial. 9 Basic affiliation Beneath your name, you should include your basic affiliation. This should take the form: Department name, institution/company name, town/city name, US state abbreviation if applicable, country name (USA or UK if applicable), e.g. Department of Russian, University of Durham, Durham, UK or Department of Chemistry, University of Buenos Aires, Buenos Aires, Argentina 10 Keywords You should list between five and 10 keywords for your article. These will not appear in print but will be incorporated in the electronic version of the article for use in online searches. Definition articles will also contain keywords. 7 11 Abstract You should include a short abstract (one paragraph) for your article. The abstract will not be displayed in print but will be made available free of charge in the online edition of the work. The abstract should contain no direct citations to elements contained in the rest of the article, e.g. figures, tables or references. 12 Main text Below is a summary of how to handle each of the main features likely to appear in the main body of your article. 12.1 Nucleic acid sequences When any sequence data is included, either the EMBL, GenBank, DDBJ or SWISS-PROT Accession Number must be given. 12.2 Gene and protein nomenclature When using genetic nomenclature, authors should follow the relevant organism-specific guidelines, e.g. Human: http://www.gene.ucl.ac.uk/nomenclature/guidelines.html Mouse: http://www.informatics.jax.org/support/nomen/ Caenorhabditis elegans: http://elegans.swmed.edu/Genome/nomen.html Drosophilia melanogaster: http://flybase.bio.indiana.edu/docs/nomenclature/lk/nomenclature.html Yeast: http://genome-www.stanford.edu/Saccharomyces/gene_guidelines.html Plant: http://genome-www.stanford.edu/mendel Zebrafish: http://zfish.uoregon.edu/zf_info/nomen.html 12.3 Genus and species names Genus and species names are always italicised. (a) In cases where the genus name has changed, please state as follows: Semibalanus (formerly Balanus) balanoides (b) In cases where both the genus and species names have changed, please use: Palaemon elegans (formerly Leander squilla) (c) In cases where the species name has changed, please use: Carcinus aestuarii (formerly C. mediterraneus) 12.4 Enzymes Names of enzymes are as recommended by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. http://www.chem.qmul.ac.uk/iubmb/enzyme/ 12.5 Chemical schemes, structures and equations Contributors should use ChemDraw where possible to create their chemical schemes and structures. Contributors are asked to submit a disk containing their chemical illustrations in addition to the printed manuscript copies. If you do not use ChemDraw, the Publisher will redraw your structures in ChemDraw. This will enable proofs to be prepared more quickly and accurately and, more importantly, will allow us in the future to integrate the work with chemical databases. (ChemDraw files can be processed as part of reaction databases which facilitate online searching.) The Publisher will edit the disk structures where necessary to ensure consistency throughout the Reference Work. 8 When using ChemDraw please use the template option, do not draw freehand. The following settings should be used when using the ChemDraw templates. Times 12 point should be used for all lettering, with the following preferences for the structures (also in points): Fixed length Line length Margin width 18 0.8 2.0 Chain angle Bold width Tolerance 120 2.5 5.0 Hash spacing Bond spacing 3.0 18% Structures must be numbered in one sequence 1 to n. The number appears in bold, centred beneath the structure. Structures do not have captions. Schemes must be numbered in one sequence 1 to n. Schemes must have captions. The caption can take the form: Scheme 1 or Scheme 1 This is a scheme. Schemes can contain embedded structures. Each Scheme should be cited in the text and flagged, i.e. “Scheme 2 near here”. Chemical reactions are numbered in the same sequence as mathematical equations. Reagents and conditions should preferably be indicated over and under reaction arrows rather than as footnotes to an Equation or Scheme. Plus and, particularly, minus signs are not always clear. All minus signs should be typed as “en” rules so that the length is the same as the horizontal line of the equivalent plus sign [Alt + 0150 on most keyboards]. No parentheses should be used with any plus or minus signs, nor should they be circled. Radicals should be indicated by a bold point centered on the appropriate letter; lone pairs should be similarly shown by two bold points. 12.6 Mathematical equations These should be numbered consecutively using arabic numerals enclosed in parentheses, written to the right of the equation, i.e. x+y=5 (5) Each equation should be cited in the text using the form: ....equation (5) describes.... or Equation (5) describes 9 but not ....eqn (5) describes... Each equation should be placed in the appropriate position within the text. Please use Word Equation Editor or MathType wherever possible. Mathematical equations should be numbered in the same sequence as chemical equations. 12.7 CAS Registry numbers We ask that Chemical Abstracts Registry Numbers be provided for each analyte in the text or as a part of any table where the compound first appears in your manuscript. The use of Registry Numbers will greatly increase the reader’s ability to retrieve additional properties through information services. 12.8 Chemical nomenclature and mathematical notation To ensure that the correct chemical nomenclature and mathematical notations are followed, contributors should refer to Dodd JS (1997) ACS Style Guide, 2nd edition, published by the American Chemical Society, Washington DC. 13 Spelling and editorial style 1. You must prepare your manuscript following American spelling and usage. Our preferred dictionary for this work is Webster's Dictionary. 2. Our default style guide is Dodd JS (ed) (1997) The ACS Style Guide, 2nd edition, American Chemical Society, Washingon, DC. 14 Symbols and units Greek letters and all less common symbols should be clearly identified for the typesetter the first time that they appear in the manuscript, by a note in the left-hand margin. It is particularly important to distinguish between the letter "oh" and "zero", between the letter "ell" and "one", between the letter "kay" and "kappa", between the letter "vee" and "nu", etc. –1 SI units should be used throughout. Negative superscripts (i.e. kJ mol ) NOT the solidus (i.e. kJ/mol) should be used. For example: –1 –1 cubic decimeter per mole-second is dm3 mol s A capital C should always be used for centigrade temperatures: 25 °C. There is always a space between the number and the unit: e.g. 24 h. Decimal points should be set on the line. Numbers from one to nine should be spelled out, unless used with a specific unit; numerals should be used for 10 and above. NB. The use of the wavenumber unit cm–1, although not strictly a SI unit, is nonetheless mandated. If, in other exceptional cases, non-SI units need to be stated, the SI equivalent should be given in parentheses. 10 15 Abbreviations and acronymns Whenever you first use an abbreviation or an acronym, you must define it in full. The Publisher will automatically generate an Encyclopedia-wide list of abbreviations and acronyms which will appear in the frontmatter pages of the work in each volume. 16 Related articles See Section 21, cross reference strategy, below. 17 Biblographic references The Harvard, i.e. name and date, reference system should be used. For example, the reference is cited in the text as (Smith, 1999) and is listed fully in an alphabetical list (according to the first author) at the end of the article. All works cited in the text, tables and figure captions should be included. Ibid or op. cit. should not be used. All names and dates in the reference list should correspond with the text citations. All references should appear together at the end of the article. They should follow the style presented below and the number of references should not exceed 20 for an Introductory or Short specialist review, 35 for an In-depth review and 10 for a Flowchart/protocol article. Definition entries will not contain references. Journal citation Kolchinsky A and Mirzabekov A (2002) Analysis of SNPs and other genomic variations using gelbased chips. Human Mutation, 19, 343-360. Lange TR, Royals HE and Connor LL (1993) Influence of water chemistry on mercury concentration in largemouth bass from Florida lakes. Transactions of the American Fisheries Society, 122, 74-84. Authored book citation Fowler J, Cohen L and Jarvis P (1998) Practical Statistics in Field Biology, Second Edition, John Wiley & Sons Ltd: Chichester. Edited book citation Gadsden D and Sparks T (2000) Field experiments. In Statistics in Ecotoxicology, Sparks T (Ed.), John Wiley & Sons Ltd: Chichester, pp. 69–98. Proceedings citation D’Angeloe LL and Lacobucci GA (1995) QSAR Studies of a Group of Structurally Diverse Artificial Sweetners using CoMFA and Design of a New Series of Aspartame Analogues, presented at 210th ACS National Meeting, Chicago, 20-24 August 1995. Sadowski J, Wagener M and Gasteiger J (1995) Proceedings of the 10th European Symposium on Structure–Activity Relationships: QSAR and Molecular Modelling, Sanz F (Ed.), Prous Science: Barcelona. 11 http citation Pyykkö P (1993) Relativistic Theory of Atoms and Molecules II. A Bibliography 1986–1992, Lecture Notes in Chemistry, Vol. 60, Springer-Verlag: Berlin. Also available on the World Wide Web: http://www.csc.fi/lul/rutan Oxford Molecular Group, The Medawar Centre, Oxford Science Park, Oxford OX4 4GA, UK. http://www.oxmol.com Database reference Esaka M, DDBJ/EMBL/GenBank databases, accession code D1021354. References to dissertations, theses and any other personal communications should not be included as they are often impossible to source. "In press" references should be limited to material that has definitely been accepted for publication and is in production; such references must contain at least the title of the journal in which the article is to appear. References whose status is ‘submitted’ but which do not include titles of journals will be deleted. 18 Further reading Further reading is an optional section. The difference between the list of references and the list of further reading is that the references must be cited in the text. Further reading items must not be cited in the text. It is imperative that both lists are kept separate. The further reading list entries should be presented in exactly the same way as the reference list entries. 19 Tables and captions Tables should be numbered consecutively with arabic numerals and grouped at the end of the manuscript. Each table should have a caption and individual column headings. Any units for columns should be in parentheses after the column heading. Footnotes to tables should be designated by superscript lower-case letters. All tables must be cited in the text and flagged, i.e. “Table 1 near here”. 20 Figures and captions Authors may submit color figures which will be reproduced in color in the online version, but it is at the Publishers discretion if the illustrations will be reproduced in color in the print version of the Encyclopedia. Figures can be line drawings, graphs, black-and-white photographs, colour photographs, etc. Please note that permission must be secured for ANY illustration which you wish to reproduce from a previously published work, even if the material is redrawn (see Section 22 below). Together with the manuscript, the Publisher requires that you submit reproduction quality hard copy figures which should, where possible, be submitted at their final size, with all lines, letters and numbers clearly legible. Figures which you wish to present in single column format should have a maximum width of 74 mm; figures which you wish to present in double column should have a maximum width of 150 mm. In both cases figures should have a maximum depth of 175 mm. You should not use line weights of less than 0.5 pt. Text labels should not be smaller than 8 pt. 12 If you supply figures outside these parameters, they will be resized and relabelled where necessary. NB the Publisher reserves the right to redraw any/all figures in the interests of establishing consistency of presentation across the work. Each figure should be identified on the back with the name of the Contributor, the unique id of the article title and the figure filename (see below). If it is not obvious, the top of the figure (i.e. its orientation) should be indicated. If possible, all illustrations should also be submitted in electronic form and should be supplied in two formats: (i) the original source file (e.g. CorelDraw, Illustrator, etc.); (ii) line drawings as Encapsulated PostScript (EPS) and photographs as TIFF. Please do not provide thumbnails or low resolution images as they will not reproduce to the required quality. Please do not provide GIF or JPEG images. If you are able to supply electronic figures, they must be supplied as separate files. Figures must not be embedded within the text file. Each figure file should contain only one figure. Each file should be filenamed using the following convention: “your_unique_id_figure_number.xxx” where xxx is the file extension of the graphics application you have used. If your unique id is g203455, then the Adobe Illustrator file containing figure 3 should be named: g203455_fig_03.ai When you submit your final manuscript, you should also suppy a list of files detailing the following: 1. 2. 3. 4. filename the application/version used to create the file type of platform/computer operating system you use whether it is black and white or colour. For example: List of figure files Filename g203455_fig_01.ai g203455_fig_02.cdx Application/version Adobe Illustrator 6.0 ChemDraw Pro 6.1 Platform/OS Mac OS X Windows 98 SE Color or black and white black and white black and white This list should be part of the manifest document which you should submit with your manuscript and permissons letters (see Section 2.4 above). Colour illustrations should be submitted as a high quality glossy print or slide and on disk if you can supply a high resolution file. The final decision as to whether illustrations in the print version will be presented in colour or in black-and-white will be made by the Publisher. 13 All figures must be mentioned in the text and should be numbered in sequence with arabic numerals, e.g. Figure 2 not Figure II. The position of a figure within the text must be indicated by a Figure Flag (i.e. “Figure 1 near here”). The captions to figures should be typed on a separate sheet and supplied at the back of the manuscript. 21 Cross reference strategy The articles should contain cross references to other articles in the Encyclopedia. This is one of the key features of any major reference work and offers significant added value to the reader. An article can contain two types of cross reference: In-line cross reference This is a cross reference in the text of an article to the title of another article. Typically this takes the form: ...(see Cytochrome)... Displayed cross reference (related articles) Displayed cross references generally take the form of a list of related articles which the reader might also find of interest. This list should be presented immediately before the references. For example the readers of an article Microarray design may also be interested in entries describing similar processes such as Protein chips or Microarray data analysis. Contributors will be responsible for inserting both types of cross reference into their articles. To assist the contributors in identifying target articles (i.e. articles which should be the subject of a cross reference), the Publisher will list all articles with their unique ids on the GGPB website at www.wiley.com/ggpb. This list will comprise the article title and its unique identifying code (unique id). Authors are asked to cross refer to other articles not by article title but by unique id. In the body of an article we would therefore expect to see: ....content....content...(see g203455)...content...content... rather than ....content....content...(see Microarray design)...content...content... where ‘g203455’ is the unique id for the article ‘Microarray design’ With regard to lists of related articles we would expect to see the following in the manuscript: Related Articles g204211g207144g201188rather than: 14 Related Articles Microarray design Protein chips Microarray data analysis The use of the unique id is critical to the speedy production of the encyclopedia and is further described in section 4 of this document. 22 Copyright, trademark and permissions If you quote lengthy passages verbatim, i.e. over 400 words, from a book or journal, then you must obtain the permission of the copyright holder in writing. Permission must also be secured for ANY table or illustration which you wish to reproduce from a previously published work, even if the material is redrawn. Copyright Permission Request Forms will be provided by the Publisher and should be sent to the copyright holder for completion. The original completed form should accompany the top copy of the manuscript (the Contributor should retain a photocopy). You must also identify the figure in the Wiley publication. No previously published figures can be reproduced in the reference work unless formal written permission has been explicitly granted and the written permission is forwarded to Wiley. You must ensure that you are granted ‘all rights in all media’. If a third party copyright holder grants you print rights but not electronic rights, you must reapply for electronic rights. Increasingly, publishers are granting electronic and print rights at the same time; however, a few publishers will only grant print rights in response to a first request and will not grant electronic rights unless they receive a subsequent request. Acknowledgment to the source of the material should be made in the figure caption using the standard Wiley wording given below or using the wording specified by the copyright holder. [Reproduced by permission of Academic Press from M. Doyle, T. Matsuda and G.M. Pohost, Magnetic Resonance in Medicine, 21, 71–74 (1991).] For books and journals, the copyright holder is usually the publisher; some publishers require that the permission of the author is also obtained. If this is the case you must contact the author and supply evidence in writing that permission has been granted by the author. For trademarks or registered products please use ™ or ® where appropriate. 23 The production process 23.1 Project management Your article will be processed by a Project Manager to be hired by John Wiley & Sons. The Project Manager will arrange for your article to be copy edited, typeset and checked by a proofreader. 15 23.2 Copy editing As part of the copy editing process, the copy editor will inevitably raise a number of queries relating to your article. We kindly request that authors respond to any queries within 48 hours of receipt. Queries will be raised by e-mail to facilitate a speedy turnaround. When replying to queries raised by a copy editor, please ensure that you answer all queries at one time (i.e. you must not supply some answers and then at a later date send some more answers). Please ensure that your answers are clear and unambiguous so that the copy editor can take them into the text without creating further errors and without the need for further queries. It is our intention that this project will be copy edited on screen. This should make the process faster and reduce the number of errors in the proofs. 23.3 Proofreading Proofs will be checked by contributors, Editors and by a professional proofreader. The Publisher will not make second or subsequent proofs available to contributors or Editors. The Publisher will provide First Page Proofs of articles to contributors for checking. Because of the scale of this work, these proofs will be typeset as single articles and paginated from 1 to n. In other words they will not carry their final pagination. Contributors will be asked to read, correct and return their proofs within two weeks of receiving them. Any contributor who is unable to do this should inform the Project Manager immediately. It is our intention to make the proofs available in PDF format and to disribute them either by FTP or by e-mail. To view PDF files you will need Acrobat Reader. It can be downloaded free of charge from www.adobe.com. This electronic proofing will speed up the production process. Contributors should be aware that corrections to proofs are both time-consuming and expensive. Contributors are therefore requested to keep their corrections to a minimum by limiting any alterations to those necessitated by errors on the part of the Publisher or the typesetter. Contributors should not regard the proof stage as an opportunity to rewrite text or make other major changes to their articles. When proofs are sent to Contributors, the Project Manager will also send an instruction document detailing how corrections are to be made and how they are to be returned to the Project Manager. Contributors are asked to follow these instructions to the letter. Particularly, contributors must not make corrections to the copy of the original (unedited) text file they keep after submisison and then send that to the Project Manager. Once corrections are returned to the Project Manager, the Project Manager will arrange a process of collation which results in corrections from the Editor, the Contributor and the professional proofreader appearing on one set of proofs. These proofs are then returned to the typesetter for correction. 16