General Biology Course (BIO101) Basic Information 1. An introductory course designed primarily for first year faculty of science students. 2. Title: General Biology : four credit hours (lecture 3 + 1 lab). Objectives of the course 1. To introduce students into the long-term key concepts in biology which represent general source for their further education. 2. Help students to recognize the methods scientists use to explore natural phenomena and learn to think as scientists. 3. Give students the opportunity to apply what they have learned by asking their own biological questions and conducting their own investigations. Course content Themes connect the concepts of biology- new properties emerge at each level in the biological hierarchy- organisms interact with their environments, exchanging matter and energy - structure and function are correlated at all levels of biological organization- cells are the basic units of structure and function of all living organismsthe continuity of life is based on heritable information in the form of DNA - feedback mechanisms regulate biological systems evolution accounts for the unity and diversity of life - Scientists use two main forms of inquiry in their study of nature - The molecule that supports all of life - Carbon: the backbone of life - The structure and function of large biological ( carbohydrates, lipids, proteins , nucleic acids) - A tour of the cell (Eukaryotic and prokartotic cells, organelles) - Membrane structure and function - The cell cycle – photosynthesis, The process that feeds the biosphere - Photosynthesis converts light energy to the chemical energy of food - cellular respiration - Meiosis and sexual life cycles - Mendel and the gene idea - The chromosomal basis of inheritance - The molecular basis of inheritance – Biodiversity (Phylogeny and the tree of life - Bacteria and arachaea – protists plant diversity – fungi – An introduction to animal diversity – invertebrates – vertebrates. Textbook: Biology, 8th ed. (2008) by Campbell, N.A. and Reece, J.B –Pearson international edition. 1- Introduction: Themes in the study of life (1.1,1.3) pages: (1-11,18-24) 2 Hours 1- Inquiring about the world of life. 2-Themes connect the concepts of biology: Evolution, the overarching theme of biology. 3- Theme: new properties emerge at each level in the biological hierarchy: a- Emergent properties b- The power and limitations of reductionism c- (Exploring levels of biological organization – from biosphere to molecule). d- Systems biology 4-Theme: organisms interact with their environments, exchanging matter and energy. a- Ecosystem dynamics b- Energy conservation 5- Theme: structure and function are correlated at all levels of biological organization. 6- Theme: cells are an organism's basic units of structure and function. 7- Theme: the continuity of life is based on heritable information in the form of DNA. a- DNA structure and function. b- systems biology at the level of cells and molecules. 8- Theme: feedback mechanisms regulate biological systems. 9-Theme: unity and diversity of life. a- organizing the diversity of life b- grouping species: the basic idea c- the three domains of life d- unity in the diversity of life Theme: Scientists use two main forms of inquiry in their study of nature. (discovery science – a case study in scientific inquiry – limitations of science – theories in science – model building in science – the culture of science – science, technology, and society). 4- Carbon and Molecular diversity of life (4.1,4.2,4.3) pages: (58-66) 2 Hours 1.Carbon: the backbone of life. 2. Carbon atoms can form diverse molecules by bonding to four other atoms. 3. A small number of chemical groups are key to the functioning of biological molecules. a-The chemical groups most important in the processes of life. b- ATP: an important source of energy for cellular processes. 5- The structure and function of large biological molecules (5.1,5.2,5.3,5.4,5.5) pages: (68-89) 1. 2. 3. 4. 5. 6. 7. 4 Hours The molecules of life Macromolecules are polymers built from monomers Carbohydrates serves as fuel and building material Lipids are a diverse group of hydrophobic Molecules Proteins have many structures resulting in a wide range of functions Nucleic acids store and transmit hereditary information The DNA double helix. Midterm Exam: From 3-4-2010 TO 7-4-2010 CHAPTER 6 : A tour of the cell (6.1,6.7) pages: (94-122) 4 Hours 1. 2. 3. 4. 5. The fundamental units of life To Study Cells biologists use microscopes and the tools of biochemistry Eukaryotic cells have internal membranes compartmentalize the functions Exploring animal and plant cells. Eukaryotic cell's genetic instructions are housed in the nucleus and carried out by the ribosomes 6. The endomembrane system regulates protein traffic and performs metabolic functions in the cell. 7. Mitochondria and chloroplasts change energy from one form to another 8. The cytoskeleton is a network of fibers that organizes structures and activities in the cell (In Brief). 9. Extracellular components and connections between cells help coordinate activities. 10. Exploring intercellular junctions in animal tissues. CHAPTER 7 : Membrane structure and function (7.1,7.5) pages: (125-139) 2 Hours 1. 2. 3. 4. Life at the edge Cellular membranes are fluid mosaics of lipids and proteins. Membrane structures results in selective permeability Passive transport is diffusion of a substance across a membrane with no energy investment 5. Active transport uses energy to move solutes against their gradients 6. Bulk transport across the plasma membrane occurs by exocytosis and endocytosis CHAPTER 12 : The cell cycle (12.1,12.2) pages: (228-237) 2 Hours 1. The key roles of cell division 2. Cell Division results in genetically identical daughter cells 3. The mitotic phase alternates with interphase in the cell cycle CHAPTER 13 : Meiosis and sexual life cycles (13.1,13.2,13.3,13.4) pages: 248-260 1. 2. 3. 4. 5. 6. 2 Hours Variation on a theme Offspring acquire genes from parents by inheriting chromosomes Fertilization and meiosis alternate in sexual life cycles The variety of sexual life cycles Meiosis reduces the number of chromosomes sets from diploid to haploid Genetic variation produced in sexual life cycles contributes to evolution CHAPTER 14: Mendel and the gene idea (14.1,14.2,14.3,14.4) pages: (262-282) 3 Hours 1. Drawing from the deck of genes 2. Mendel used the scientific approach to identify two laws of inheritance(the law of segregation and the law of independent assortment). 3. The laws of probability govern Mendelian inheritance 4. Inheritance patterns are often more complex than predicted by simple Mendelian genetics 5. Many human traits follow Mendelian patterns of inheritance. CHAPTER 15: The chromosomal basis of inheritance (15.1,15.4) pages: (286-289) 2Hours 1. Locating genes along chromosomes 2. Mendelian inheritance has its physical basis in the behavior of chromosomes UNIT 2 : CHAPTER 16: The molecular basis of inheritance (16.1,16.2,16.3) pages: (305-323) 1. 2. 3. 4. 3 Hours Life's operating instructions DNA is the genetic material Many proteins work together in DNA replication and repair A chromosome consists of a DNA molecule packed together with proteins CHAPTER 32: an introduction to animal diversity (32.1,32.4) page (654-655,661-662) 1Hour 1-Welcome to our kingdom 2-Animals are multicellular,heterotrophic eukaryotes with tissues that develop from embryonic layers CHAPTER 33: invertebrates Pages: (666-669) 2Hours 1- Life without a backbone 2- Exploring Invertebrate diversity CHAPTER 34: vertebrates Pages: (698-701) 1Hours 1- Half a billion years of backbone 2- Chordates have a notochord and a dorsal, hollow nerve cord - Derived Characters of Chordates *Notochord *Dorsal hollow nerve cord *Pharyngeal slits or clefts *Muscular, post-anal tail Grade Distribution: INSTRUCTORS: Midterm Exam: 15 Dr. Mohammad Asem Practical Part: 25 Dr. Adel Abdelmageed Assignments, ….etc.: 10 Dr. Sherif Shaarawy Final Exam: 50 Dr. Annur Abdelmajid Total: 100 Dr. Al-Sayed Fuda Dr. Ahmad Hussein Dr. Loay Hassonah Dr. Ahmed Maslat