CURRICULUM VITAE
Name:
Robert L. Martuza, M.D.
Office Address:
Higgins Professor of Neurosurgery
Chief, Neurosurgery Service
Massachusetts General Hospital WHT502
55 Fruit Street, Boston, MA. 02114-2696
Phone: 617-726-8581
Fax: 617-726-4814
Email:
rmartuza@partners.org
Place of Birth:
Wilkes-Barre, PA (USA)
Date of Birth:
July 1, l948
Education:
1969
1973
B.A.
M.D.
Bucknell University, Lewisburg, PA
Harvard Medical School, Boston, MA
Postdoctoral Training:
Internship and Residencies:
1973-1974
1975-1979
1979
Intern in General Surgery,
Massachusetts General Hospital, Boston, MA
Resident in Neurosurgery,
Massachusetts General Hospital, Boston, MA
Chief Resident in Neurosurgery,
Massachusetts General Hospital, Boston, MA
1
Research Fellowships:
1972-1973
1974-1975
Student Research Fellow in Virology
(Tumor virology; Dr. Paul Black)
Massachusetts General Hospital
Clinical and Research Fellow in Neurosurgery
Neurosurgical Oncology
Massachusetts General Hospital
Licensure and Certification:
1976
1983
1985
Massachusetts Medical License Registration
(39007; issued 1/30/76)
American Board of Neurological Surgeons
(Board certified, May l983)
Fellow, American College of Surgeons
Academic Appointments:
1980-1981
1981-1986
1986-1991
1991-2000
2000-
Instructor in Surgery, Harvard Medical School
Assistant Professor of Surgery
Harvard Medical School
Associate Professor of Surgery,
Harvard Medical School
Professor and Chairman,
Department of Neurosurgery,
Georgetown University
Higgins Professor of Neurosurgery
Harvard Medical School
Hospital Appointments:
1980-1981
1981-1986
1987-1991
1991-2000
2000-
Assistant in Neurosurgery,
Massachusetts General Hospital
Assistant Visiting Neurosurgeon,
Massachusetts General Hospital
Associate Visiting Neurosurgeon,
Massachusetts General Hospital
Professor and Chairman,
Department of Neurosurgery,
Georgetown University Hospital
Chief, Neurosurgery Service
Massachusetts General Hospital
2
Other Professional Positions and Major Visiting Appointments:
1980-1991
1988-1991
1992-2000
1999-2000
2000-present
Director, Neurofibromatosis Clinic
Massachusetts General Hospital
Co-director, MGH Brain Tumor Center
Director, Georgetown Brain Tumor Center
Associate Director for Clinical Research
Lombardi Cancer Center, Georgetown University
Director, MGH Brain Tumor Center
Principal Clinical and Hospital Service Responsibilities:
1980-1982
1980-1983
1980-1983
1981-1983
1981-1991
1981-1984
1984-1986
1987-1988
1989-1991
1989-1991
1991-2000
1991-2000
1991-2000
1992
1993
1993-1998
1993
1993-1998
1994
Emergency Ward Committee, Massachusetts
General Hospital
Neurosurgical Intensive Care Unit Committee
Massachusetts General Hospital
Co-director of Neurosurgical
Intensive Care Unit
Massachusetts General Hospital
Subcommittee Review for Research Proposals,
Massachusetts General Hospital
Cancer Affairs Committee, Massachusetts
General Hospital
CT Subcommittee, Massachusetts General
Hospital
Chairman, Laser Safety Committee,
Massachusetts General Hospital
Chairman, Ad Hoc Committee on Lasers,
Massachusetts General Hospital
General Clinical Research Center Advisory
Committee, MGH
MGH Laser Committee
Georgetown Operating Room Committee
Georgetown Executive Faculty Committee
Georgetown Executive Staff Committee
Georgetown Ophthalmology Chairman Search Committee
Fiscal Affairs Committee,
Georgetown Faculty Practice Group
Georgetown Space Utilization Committee
Georgetown Endocrinology Chief Search Committee
Georgetown, Internal Advisory Board for The Program
in Cognitive and Computational Sciences
Chair, Search Committee for Chair of Neuroscience
Department, Georgetown University
3
1994-1999
1999-2000
2000-present
2000-present
2001-present
2000-present
Staff Appointments Committee
Georgetown University Medical Center
Associate Director for Clinical Research
Lombardi Cancer Center, Georgetown University
Managed Care Committee,
Massachusetts General Hospital
Executive Committee on Research,
Massachusetts General Hospital
General Executive Committee, The Massachusetts General
Hospital Corporation
Partners Research Council, Partners Healthcare
Major Committee Assignments:
National and Regional
1981-1991
1983
1984
1985
1986-1990
1987
l988-1991
l989
1991
1991
1991
Medical Advisory Board of the National
Neuro-fibromatosis Foundation, New York,
New York
Joint Committee on Education, Congress of
Neurological Surgeons and American
Association of Neurological Surgeons
Member of Executive Committee,
Joint Section on Tumors,
Congress of Neurological Surgeons,
American Association of Neurological Surgeons
Subcommittee on Research of Brain Tumors,
Congress of Neurological Surgeons
Co-Chairman of Research Advisory Board,
National Neurofibromatosis Foundation
Joint Subcommittee on Research, Congress of
Neurological Surgeons, American Association
of Neurological Surgeons
Joint Section on Stereotactic and Functional
Neurosurgery
The Academy Resident Award Committee,
The American Academy of Neurological Surgery
First World Health Organization Planning
Conference on Neurofibromatosis, FL
Planning committee for NIH Consensus
Conference on Acoustic Neuroma
Ethics and Human Values Committee,
American Association of Neurological Surgeons
4
1992
1991-1992
1993-1996
1994-2000
1994-1997
1994-1998
1996
1997-present
1998
1998
1998-present
1998-1999
1999-present
1999-present
2000-present
Chairman, The Academy of Neurological Surgery
Resident Award Committee
Co-director, Review and Update in
Neurobiology for Neurosurgeons,
Woods Hole, MA
Co-Chair, Technology Assessment Committee,
Society of Neurological Surgeons
National Cancer Advisory Board, Liaison
Joint Washington Committee, Congress of
Chairman, Decade of the Brain Task Force
American Association of Neurological Surgeons
Congress of Neurological Surgeons
Member NIH Site Visit Team, University of
Scientific Advisory Board, MediGene, Inc, (Neurovir, Inc.).
NIH Grant Reviewer for NSD-B study section meeting
NIH Grant Reviewer for NCI-F study section on Training Grants in
Surgery
American Society of Gene Therapy, coordinating reviewer
Member of NIH/NINDS Brain Tumor Genome Anatomy Project
Program Committee, American Society of Gene Therapy
Board of Scientific Counselors, National Institute of Neurological
Disorders and Stroke (NINDS)
Scientic Advisory Board, Direct Gene, Inc.
Professional Societies:
1980-1991
1980-present
1982-present
1982-1991
1983-1991; 2000-present
1983-1991
1983-present
1985-present
1986-1991
1986-1991
1986-present
l988-present
l988-present
Massachusetts Medical Society
American Medical Association
Congress of Neurological Surgery
American Society for Laser Medicine
and Surgery
New England Neurosurgical Society
Massachusetts Neurosurgical Society
American Association of Neurological Surgeons
Fellow of the American College of Surgeons
The New York Academy of Sciences
Massachusetts Chapter,
American College of Surgeons
Society for Neuroscience
The American Society for Stereotactic and
Functional Neurosurgery
World Society for Stereotactic and Functional
Neurosurgery
5
l988-present
1989-present
1991-present
1992-present
1992-present
1992-2000
1995-present
1997-present
1998-present
2000-2003
2002-2003
Member, Section of Surgery
Royal Society of Medicine
American Academy of Neurological Surgeons
American College of Surgeons, Washington,
Society of Neurological Surgery
D.C. Medical Society
Southern Neurosurgical Society
The Charles A. Dana Foundation
American Association for Cancer Research
American Society of Gene Therapy
Member, Cancer Gene Therapy Committee, American Society
of Gene Therapy
Co-chair, Program Committee, American Society of Gene Therapy
Editorial Boards:
1987-89
1989-present
1993-present
1997-present
1997-present
1998-present
1999-present
2000-present
Assistant Clinical Editor, Neurofibromatosis Research Newsletter
Editorial Board, Journal of Neuro-oncology
Editorial Board, Cancer Gene Therapy
Commentator, Neurologia medico-chirurgica
Editorial Board, Brain Tumor Pathology
Editorial Board, Neoplasia
Editorial Board, Journal of Neurosurgery
Scientific Advisory Board, Encyclopedia of Neuroscience.
Awards and Honors:
1968
1969
1969
1973
1973
1988
1989
1994
1998
Phi Beta Kappa, Bucknell University
Louis Robey Award, Bucknell University
Cum Laude, Chemistry, Bucknell University
Alpha Omega Alpha, Harvard Medical School
Magna Cum Laude (thesis in a special field),
Harvard Medical School
Traveling Fellowship from The Royal College
of Surgeons of England
Von Recklinghausen's Award for the advancement of
medical sciences in the field of neuro-fibromatosis;
from the National Neuro-fibromatosis Foundation
Grass Award, Society of Neurological Surgeons
NF, Inc. Scholar Award
6
Funded Grants:
1982-1987
1982
1983-1986
1983-1986
1985-1988
1986-1987
1986-1987
1986-1987
1986-1990
1987-1990
1989
1990-1992
Teacher-Investigator Development Award
(NS00654) "Neurofibromatosis: Cellular features,
hormonal controls"
Principal Investigator, National
Neurofibromatosis Foundation Research Grant
Physician's Recognition Award, American
Medical Association
Principal Investigator, National Institutes
of Health Grant (RO1NS20025) "Hormonal
modulation of tumors of neurofibromatosis"
Co-investigator, National Neurofibromatosis
Research Grant "DNA transfection analysis of the
tumors of neurofibromatosis" (P.I., L. Jacoby)
Principal Investigator, Whitaker Health
Sciences Fund Grant "The combined treatment
of malignant brain tumors with stereotactically applied photodynamic therapy,
hyperthermia, and ionizing radiation"
Principal Investigator, National Neurofibromatosis Foundation Research Grant
"Melanocyte growth and modulation in neurofibromatosis"
Co-investigator, National Neurofibromatosis
Foundation Research Grant, "Chromosomal
alterations in tumors associated with bilateral acoustic neurofibromatosis: a
molecular genetic approach focused on
chromosome 22" (P.I., B. Seizinger)
Principal Investigator, renewal of
RO1NS20025,"Hormonal modulation of tumors of
neurofibromatosis"
Principal Investigator "Studies of
melanocytes in neurofibromatosis and tuberous
sclerosis". Neurogenetics Center Grant
(PO1-NS24279)
Principal Investigator "Evaluation of a twowavelength laser in neurosurgery" subcontract
via Abiomed,Inc. from National Institutes of Health
Principal Investigator "Genetic alteration of
nervous system tumors", project 2 of
Neurogenetics Center Grant (l-PO1-NS24279)
7
1993-1996
1994-1997
1994-1998
1994-1998
1994-1998
1996-1999
1997-2002
1997-1999
1998-2001
1998-2000
1998-2003
1998-2003
2001-2006
Principal Investigator "Molecular targeting
of therapy for nervous system tumors".
(P20-CA60176-01)
Co-Investigator, "Gene delivery to the CNS to
modulate epilepsy" (S. Rabkin, PI)(R01 NS 33342)
Principal Investigator "National CNS Tumor
Consortium - Georgetown/Lombardi
Cancer Center" (U01 CA62454)
Principal Investigator, "Genetically engineered viruses
for brain tumor therapy" (R01 NS 32677)
Co-investigator, "Early clinical trials of antiangiogenesis agents"
M. Hawkins, PI (U01 CA62500)
Principal Investigator, subcontract, 3-D Aids to stereotactic brain
cancer surgery (R44 NS32610-03)
Program Leader, Neuro-oncology, Cancer Center Support
Principal Investigator, Pre-clinical studies of G207 (Neurovir, Inc.)
Principal Investigator, “Herpes vectors for prostate cancer therapy”
CaPCURE Foundation
Co- Investigator, A dose escalating Phase I Study of the treatment
of Malignant Gliomas with G207, a genetically engineered HSV-1
(Neurovir, Inc.)
Principal Investigator, “Herpes virus therapy of prostate cancer”,
Dept. of Defense (DAMD17-98-1-8490)
Principal Investigator, "Genetically engineered viruses
for brain tumor therapy" (R01 NS 32677)
Principal Investigator, "Clinical Research Training Program in
Neuro-Oncology", National Cancer Institute, (K12-CA90354)
Major Research Interests:
1. Central Nervous System Tumors: Alteration or destruction of tumor cells by genetically
engineered viruses. Studies of etiology, modulation, and treatment of nervous system tumors.
Use of biologic modifiers, gene and viral therapy to treat nervous system tumors.
2. Neurofibromatosis: Clinical aspects; pathogenesis of the meningeal, Schwann cell and glial
tumors. Experimental therapeutics using anti-angiogenesis agents and “nerve-sparing” viral
vectors.
3. Cancer Therapy with Viral Vectors: Development of HSV1-derived vectors to treat prostate
and other cancers. Development of “nerve-sparing vectors” for cancer therapy and viral vectors
and cell-specific vectors as oncolytic agents and as in situ anti-cancer vaccines.
8
4. Molecular Neurosurgery: Use of viral vectors and genetically engineered cells for gene transfer
in vitro and in vivo in order to alter nervous system function and treat intrinsic nervous system
and neuro-vascular diseases.
5. Minimally Invasive Image-Guided Neurosurgery: Use and understanding of MRI, CT and
ultrasound to improve minimally invasive Neurosurgery.
Teaching Experience:
1976
1980
1981-1989
1983
1980-1990
1990
1993
1995
1996-1999
1998-1999
1998-1999
Developed and directed a continuing
neuro-pathology course for neurosurgery
residents
Instructor in Surgery for Introduction to the
Clinic for Harvard Medical Students
Developed and instructed a lecture and
dissection course in neuroanatomy and
peripheral nerve surgery for neurosurgery
residents
Developed and directed with the National
Neurofibromatosis Foundation a symposium for
physicians and associated health care
persons. "Neurofibromatosis: Clinical care
research directions".
Lecturer, MGH Neurosurgery
Post-graduate Course
Organizer, moderator, speaker in section on
malignant brain tumors MGH Neurosurgery
Post-graduate Course
Lecturer, Frontiers in Medicine
Georgetown Physiology Graduate Lecture Series
Lecturer, Neuroscience Survey Course
Medical student lectures on neurosurgery, Georgetown
Medical student and Neurology resident lectures on CNS tumors
Lecturer, Neuroscience Survey Course, Georgetown University
Invited lectures and Visiting Professorships
1981
1984
1987
Invited lecturer "Lasers and phototherapy in
Neurosurgery", Mayo Clinic
Invited lecturer, CT Stereotactic-Surgery,
University of Utah School of Medicine
Invited Guest Speaker, First LINK Conference
on Neurofibromatosis, Runnymeade, England
9
1987-1993
1988
1988
1988
1988
1989
1988
1989
1990
1990
1990
1990
1990
1991
1991
1992
1992
1992
1992
1992
1992
1993
Invited lecturer at Woods Hole course "Review
and Update in Neuroscience for Neurosurgeons"
Visiting Professor and lecturer, The Royal
Hallamshire Hospital, Sheffield, England
Visiting Fellow and Lecturer, The Frenchay
Hospital, Bristol, England
Visiting Fellow and Lecturer, The Midland
Centre for Neurosurgery, Birmingham, England
Visiting Fellow and Lecturer, Radcliffe
Infirmary, Oxford, England
Invited Speaker and Session Chairman, First
Meeting of the International Society on
Neurocutaneous Disorders, Tokyo, Japan
Invited Guest Speaker, The American Academy
of Neurological Surgery, Tuscon
Visiting Professor, Chicago Neurosurgical Center
Visiting Professor, Dartmouth Medical School
Organizer and speaker,
First MGH Brain Tumor Workshop
Invited Speaker, Banbury Conference on
Neurofibromatosis, Cold Spring Harbor, NY
Guest Speaker, American Neurological
Association, Atlanta
Invited Guest Speaker, 8th Nikko Brain Tumor
Conference, Saga, Japan
Co-director, Woods Hole course "Review and
Update in Neuroscience for Neurosurgeons"
Browder Memorial Lecture, New York
Neurosurgical Society
Arkin Memorial Lectureship, Chicago
Children's Hospital
Invited Guest Speaker, LINK Conference on
Neurofibromatosis, Oxford, U.K.
Invited speaker, American Academy of
Neurological Surgeons
Invited Guest Speaker,
5th Canadian Neuro-Oncology Meeting
First Visiting Professor, Carolyn Farb
Endowment Fund in Neurofibromatosis,
M.D. Anderson Cancer Center
Invited speaker, Preuss Foundation Seminar,
Miami Beach
Invited speaker, Decade of the Brain Symposium
"Advances in the Treatment of Brain Tumors", Univ. Cincinnati
10
1993
1993
1993
1993
1993
1993
1993
1994
1994
1994
1994
1994
1994
1994
1995
1994
1994
1994
1995
1994
Invited guest lecturer, Japan Neurosurgery
Society, Tokyo
Visiting Professor, Asan Medical Center,
Seoul, Korea
Galbraith Lectureship and Visiting Professor
University of Alablama
Janssen Distinguished Lecturer, "Current concepts
in brain tumor biology and therapy", 21st Annual
Meeting, SNACC, Washington, DC
Invited speaker, Second Conference on Cancer
Gene Therapy, San Diego
Invited Lecturer, UCLA post-graduate update
on brain tumor therapy, Los Angeles
Invited speaker, Scandinavian Glioma
Conference, Copenhagen
Visiting Professor, Emory University
Altman Lecturer, University of Pennsylvania
Keith Visiting Lectureship,
University of Toronto
Visiting Professor and guest lecturer
University of Chicago
Chairman and lecturer
Decade of the Brain Symposium
"Gene Therapy in the Nervous System"
1994 AANS meeting, San Diego
Invited speaker, Preuss Foundation Seminar on
Tumor markers for glial tumors, San Diego
Invited speaker, Grass Award Lecture,
Society of Neurological Surgeons,
Charlottesville, VA
Invited Lecturer, 7th Canadian Neuro-oncology
Meeting, Calgary
Guest speaker, Canadian Congress of
Neurological Sciences, St. Johns, Newfoundland
Session leader and guest speaker,
Therapeutic approaches to neurofibromatosis
FASEB conference on neurofibromatosis
Santa Cruz, CA
Aitken Memorial Lecture, London, Ontario
Invited speaker, Brain Tumor Symposium on New
Therapies, Hutchinson Cancer Center, Seattle
Invited speaker, Taxin Brain Tumor Symposium,
Wistar Institute, Philadelphia, PA
11
1995
1995
1995
1995
1996
1996
1995
1996
1996
1997
1997
1995
1996
1997
1996
1996
1996
1997
1997
Neuro-oncology Lectureship
Visiting Professor, Mayo Clinic
Lecturer, Gene Therapy Series,
National Institutes of Health
Invited Speaker and Scientific Committee Member
Gene Therapy for CNS Disorders,
Univ. of Pennsylvania, Philadelphia, PA
Session Leader and invited speaker,
NNFF International Consortium for Molecular
Biology of NF1 and NF2, Philadelphia, PA
Invited Speaker, "Development of replication
competent viruses for therapy of brain
tumors" at the "International Symposium of
Molecular Neurosurgery Based on Gene Therapy" Nagoya, Japan
Invited Speaker and Chair of Gene Therapy
Session, The Eleventh International Conference on
Brain Tumor Research and Therapy,
Napa, California, U.S.A.
Invited Speaker, Delaware Neurosurgical Society
Invited Speaker, Huntsman Cancer Center,
Salt Lake City, Utah
Invited speaker, Preuss Conference on Gene
Therapy for Brain Tumors, San Diego, CA.
Visiting Professor, Jefferson Medical
College, Philadelphia, PA
Invited lecturer, Univ. Michigan Cancer
Center, Ann Arbor, MI
Invited lecturer, Univ. So. Carolina,
Charleston, SC
Chair, AANS Decade of the Brain Symposium,
"Watching the Brain Work", Minneapolis, Minn.
Invited Speaker and Moderator of section on
CNS Gene Therapy, TIGR Gene Therapy
Conference, Hilton Head, NC
Chair, Section on Experimental Therapeutics
for NF, FASEB Conference on NF, Aspen, Colo.
Visiting Professor, Henry Ford Hospital,
Detroit, MI
Invited speaker, FDA/NIH conference on Gene
Therapy, Bethesda, Md.
Pennathur Sundarum Memorial Lecturer,
HerpesVirus Therapy of Cancer,
Massachusetts General Hospital, Boston
Invited Speaker, NIH Conference on Herpes Vectors
12
1997
1998
1997
1997
1998
1998
1999
1998
1998
1999
1997
1998
1998
1999
1999
1999
1999
1999
1999
1999
1999
1999
1999
1999
2000
Visiting Professor, Wake Forest University Medical
Center (formerly Bowman-Gray Medical School)
Invited Lecturer, New York University post graduate course, “A
Systems Approach to Glial Neoplasms”
Invited speaker, Workshop on NF2:Present and Future,
Bethesda,MD
Invited Lecturer, Wood’s Hole RUNN course
Invited speaker, AANS Tumor Satellite Meeting, Phila., PA
Invited speaker, American Society of Gene Therapy, First Annual
Meeting, Seattle, WA. “Herpes virus targeting of glioblastoma”
Invited speaker, First International Congress, Genetics in
Neuroscience, Terni, Italy
Invited speaker, CaPCURE Annual Research Retreat
Invited Lecturer, Wood’s Hole RUNN course
Chairman and speaker of session on “Neurocutaneous
Syndromes”, Congress of Neurological Surgeons meeting, Seattle
Speaker and symposium moderator, “State of the Art Treatment of
Brain Tumors”; American Brain Tumor Association and
Childhood Brain Tumor Foundation, Washington, D.C.
Invited Lecturer, New York University post graduate course, “A
Systems Approach to Glial Neoplasms”
Invited lecturer, Institute for Human Gene Therapy Annual Retreat,
Univ. Pennsylvania
Visiting Professor and Invited speaker, Johns Hopkins Medical
School, Dept. Neurosurgery
The First Annual Arthur and Sonia Labatt Brain Tumor Research
Center Academic Lecturer, Toronto
Invited speaker, Second US-Japan Gene Therapy Conference,
Bethesda, MD
Invited Speaker, “Conditionally replicating herpes vectors for
tumor therapy”, Amer. Assoc. for Cancer Research 90th meeting,
Philadelphia, PA
Chair, Cancer I Session, American Society of Gene Therapy,
Second Annual Meeting, Washington, DC
Invited speaker, International Heresvirus Workshop,
Cambridge, MA
Invited Speaker, “Development of herpes vectors for cancer
therapy”, National Cancer Institute Phase I Meeting, Bethesda, MD
Invited presenter, CaPCURE Annual Research Retreat
Visiting Professor, Saga Medical School, Saga, Japan
Visiting Professor, Nagoya Medical School, Nagoya, Japan
Honored Guest Speaker, 58th Japan Neurosurgical Society, Tokyo
Invited Speaker, RUNN Course, Woods Hole, MA
13
2000
2001
2001
2002
2002
2002
2002
2002
2002
2002
2003
Invited Speaker, “Development of herpes vectors for abnormal
prostate cancer”, CaPCURE Retreat, Lake Tahoe, Nevada
Invited Speaker, Second International Symposium on Genetic
Anticancer Agents, Valencia, Spain
Invited speaker, CaPCURE Eighth Annual Scientific Retreat, Lake
Taho, Nevada
Invited Speaker , 93rd Annual Meeting, American Association for
Cancer Research, San Francisco, CA
Invited Speaker and Moderator, Annual Meeting, American
Association of Neurological Surgeons, Chicago, Il.
Invited Speaker, 53rd Annual Meeting of the German Society of
Neurosurgery, Halle/Saale, Germany
Invited Speaker, Third International Symposium on Genetic
Anticancer Agents, Amsterdam, The Netherlands
Invited Speaker, Japan Neurosurgical Society 61st Annual Meeting,
Matsumoto, Japan
Keiji Sano Lectureship, Teikyo University School of Medicine,
Tokyo, Japan
Invited Speaker, Brain Tumor Forum, Nagoya Brain Tumor
Society, Nagoya Japan
Invited Speaker, Oncolytic Viruses as Cancer Therapeutics
Conference, Banff , Alberta Canada
Inventions and Patents
1.
2.
3.
4.
5.
6.
7.
8.
9.
Inhibition of neurofibrosarcoma growth and angiogenesis (patent filed 1990; patent issued
July 18, 2000; # 6,090,794)
Viral mediated destruction of neoplastic cells (patent filed 1990)
Viral targeted destruction of neoplastic cells (patent filed 1990)
Transfer and expression of gene sequences into central nervous system cells using herpes
simplex virus mutants with deletions in genes for viral replication (patent filed 1992)
Replication-competent herpes simplex-1 virus mediates destruction
of neoplastic cells (patent filed 1994; patent issued Dec.17, 1996; #5,585,096)
Tumor- or cell- specific herpes simplex viral replication (patent filed 1995; patent issued
Mar.17, 1998; #5,728,379)
Use of herpes vectors for tumor therapy (application #60/055,142; filed 08/12/97)
Implanting HSV-TK Retrovirus Producing Cells To Treat Tumors (patent filed 1995, patent
issued 08/462,508)
Implantation of HSV-TK Retrovirus Producer Cells to Destory Glioma (patent filed 1995,
patent issued: 08/462,500)
14
Bibliography
Original Reports (Published and In Press)
1.
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4.
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Martuza RL, Black PH, Kornblith PL, Dohan FC Jr. Evidence for presence of a virus in
glioblastoma multiforme cells. Surg Forum 1973; 24:459-461.
Martuza RL, Shamberger RC, Phillips JP, Kornblith PL, Dohan FC Jr, Hochberg FH. A
lymphocyte-dependent antibody assay for detection of antibodies to human glioma cells.
Surg Forum 1975; 24:492-494.
Martuza RL, Profitt MR, Moore MB, Dohan CF Jr. Evaporation as a cause of positional
differences in cell plating and growth in microtiter plates. Transplantation 1976;
2l:271-273
Stewart RM, Martuza RL, Baldessarini RJ, Kornblith PL. Glutamate accumulation by
human gliomas and meningiomas in tissue culture. Brain Research 1976; 118:441-452.
Phillips JP, Sujatanond M, Martuza RL, Quindlen EA, Wood WC, Kornblith PL, Dohan
DC Jr. Cytotoxic antibodies in preoperative glioma patients: A diagnostic assay. Acta
Neurochir. 1976; 35:43-52
Martuza RL, Kornblith PL, Liszczak TM. Characteristics of human optic gliomas in tissue
culture. J Neurosurg 1977; 46:78-84.
Chapman PH, Martuza RL, Poletti CE, Karchmer AW. Symptomatic spinal epidural
lipomatosis associated with Cushing's Syndrome. Neurosurgery. 1981; 8:724-727.
Martuza RL, Ojemann RG, Shillito J, Wepsic JG. Facial pain associated with a middle
fossa arachnoid cyst. Neurosurgery 1981; 8:712-716.
Martuza RL, MacLaughlin DT, Ojemann RG. Specific estradiol binding in schwannomas,
meningiomas, and neurofibromas. Neurosurgery 1981; 9:665-671
Martuza RL, Ojemann RG. Bilateral acoustic neuromas: clinical aspects, pathogenesis,
and treatment. Neurosurgery l982; l0:l-l2.
Martuza RL, Liszczak T, Okun A, Wang T-Y. Human neurofibromas in co-culture with
mouse neurons. Ann Proc Electron Microscopy Soc Amer 1982; 194-195
Conner ES, Martuza RL, Heros RC. Seizures due to metrizamide myelography in patients
with acute cervical spine injury. Neurosurgery 1982; 10:266-267.
Nakagawa H, Hori Y, Sato S, Fitzpatrick TB, Martuza RL. The nature and origin of the
melanin macroglobule. J Invest Dermatol 1984; 83:134-139.
Granick MS, Martuza RL, Parker SW, Ojemann RG, Montgomery WW. Clinical
manifestations and diagnosis of cerebellopontine angle meningiomas. Ann Otol Rhinol
Laryngol, 1985; 94:34-38.
Martuza RL, Miller DC, MacLaughlin DT. Estrogen and progestin binding by cytosolic
and nuclear fractions of human meningiomas. J Neurosurg 1985; 62:750-756.
Jay JR, MacLaughlin DT, Riley KR, Martuza RL. Modulation of meningioma cell growth
by sex steroid hormones in vitro. J Neurosurg l985; 62:757-762.
Mirimanoff RO, Dosoretz DE, Linggood RM, Ojemann RG, Martuza RL. Meningioma:
Analysis of recurrence and progression following neurosurgical resection. J Neurosurg
l985; 62:l8-24.
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34.
Martuza RL, Phillipe I, Fitzpatrick TB, Zwaan J, Seki Y, Lederman J. A quantitative study
of melanin macroglobules as a cellular marker of neurofibromatosis: A quantitative study.
J Invest Dermatol l985; 85:347-350.
Jacoby L, Martuza RL. DNA transfection analysis of tumors of neurofibromatosis. Ann
NY Acad Sci l986; 486:333-335.
Jay JR, MacLaughlin DT, Badger TM, Miller DC, Martuza RL. Hormonal modulation of
Schwann cell tumors. I. The effects of estradiol and Tamoxifen on
methyl-nitrosourea-induced rat Schwann cell tumors. Ann NY Acad Sci l986;
486:371-382
Fitzpatrick TB, and Martuza RL. Clinical diagnosis of von Recklinghausen's
neurofibromatosis. Ann NY Acad Sci l986; 486:383-385.
Kostron H, Swartz MR, Miller DC, Martuza RL. The interaction of hematoporphyrin
derivative, light, and ionizing radiation in a rat glioma model. Cancer l986; 57:964-l970.
Brockes JP, Breakefield XO, Martuza RL: Glial growth factor-like activity in Schwann
cell tumors. Ann Neurol l986; 20:3l7-322.
Steichen JD, Dashner BA, Martuza RL: The distribution of hematoporphyrin derivative in
a canine glioma following intraneoplastic and intraperitoneal injection. J Neurosurg l986;
65:364-369.
Cohen AM, Wood WC, Bamberg M, Martuza R. Cytotoxicity of human brain tumors by
hematoporphyrin derivative. J Surg Res 1986; 41:81-83
Kostron H, Bellnier DA, Lin CW, Schwartz MR, Martuza RL. Distribution, retention, and
phototoxicity of hematoporphyrin derivative in a rat glioma. Intraneoplastic versus
intraperitoneal injection. J Neurosurg l986; 64:768-774.
Seizinger BR, Martuza RL, Gusella JF. Loss of genes on chromosome 22 in tumorigenesis
of acoustic neuroma. Nature l986; 322:644-647.
Boukoms A, Martuza RL, Henderson M. Capgras Syndrome with Subarachnoid
Hemorrhage. J Nerv Ment Dis l987; 174:484-488
Seizinger BR, Rouleau G, Ozelius LJ, Lane AH, St. George-Hyslop P, Huson S. Gusella
JF, Martuza RL. Common pathogenetic mechanism for three tumor types in bilateral
acoustic neurofibromatosis. Science l987; 236:317-319
Seizinger BR, de la Monte S, Atkins L, Gusella JF, Martuza RL. Molecular genetic
approach to human meningioma: loss of genes on chromosome 22. Proc Natl Acad Sci
l987; 84:54l9-5423.
Seizinger BR, Rouleau GA, Ozelius LJ, Lane AH, Faryniarz AG, Chao MV, Huson S, Korf
BR, Parry DM, Pericak-Vance MA, Collins FS, Hobbs W, Falcone BG, et al. Genetic
linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene.
Cell l987; 49: 589-594.
Rouleau GA, Wertelecki W, Haines JL, Hobbs WJ, Trofatter JA, Seizinger BR, Martuza
RL, Superneau DW, Conneally PM, Gusella JF. Genetic linkage of bilateral acoustic
neurofibromatosis to a DNA marker on chromosome 22. Nature 1987; 329: 246-248
Seizinger BR, Martuza RL, Rouleau G, Breakefield XO, Gusella. Models for inherited
susceptibility to cancer in the nervous system: A molecular-genetic approach to
neurofibromatosis. Dev. Neurosci. 1987; 9: 144-153
Nadol JR, Levine R, Martuza RL, Ojemann RG, Montgomery WW, DeSandoval PK:
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Preservation of hearing in surgical removal of acoustic neuromas of the internal auditory
canal and cerebellar pontine angle. Laryngoscope l987; 97: No. 11, l287-1294.
Kostron H, Swartz MR, Martuza RL. Photodynamic therapy is potentiated by Co60 and
intratumoral injection of hematoporphyrin derivative. J Neurooncol 1988; 6:185-191.
Seizinger BR, Rouleau GA, Ozelius LJ, Lane AH, Farmer GE,... Martuza RL, et al: Von
Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell
carcinoma. Nature l988; 332:268-269
Seizinger BR, Farmer GE, Haines JL, Ozelius LJ, Anderson K, Korf BR, Parry DM,
Pericak-Vance MA, Mulvihill JJ, Menon A, Hobbs WJ, Martuza RL, Gusella JF: Flanking
markers for the gene causing von Recklinghausen neurofibromatosis (NF-l). Am J Hum
Genet l989; 44:30-32.
Louis DN, Hedley-Whyte TE, Martuza RL: Sarcomatous proliferation of the vasculature
in a subependymoma. Acta Neuropath 1989; 78:332-335.
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Medhkour A, Van Roey M, Sobel RA, Fingert HJ, Martuza RL. Implantation of human
meningiomas into the sub-renal capsule of the nude mouse: A model for studies of tumor
growth. J Neurosurg 1989; 71: 545-550.
El-Azouzi M, Chung R, Farmer GE, Martuza RL, et al. Loss of distinct regions on the
short arm of chromosome 17 associated with tumorigenesis of human astrocytomas. Proc
Natl Acad Sci USA 1989; 86: 7186-7190.
Rouleau GA, Seizinger BR, Wertelecki W, Haines JL, Superneau DW, Martuza RL,
Gusella JF. Flanking markers bracket the neurofibromatosis type 2 (NF2) gene on
chromosome 22. Am J Hum Genet 1990; 46: 323-328
Logan JA, Seizinger BR, Atkins L, Martuza RL. Loss of the Y chromosome in
meningiomas: a molecular genetic approach. Cancer Genet Cytogenet 1990; 45:41-47.
Lee JK, Kim TS, Chiocca EA, Medhkour A, Martuza RL. Growth of human
Schwannomas in the sub-renal capsule of the nude mouse. Neurosurgery 1990; 26:
598-605.
Lee JK, Choi B, Sobel RA, Chiocca EA, Martuza RL. Inhibition of growth and
angiogenesis of a human neurofibrosarcoma by heparin and hydrocortisone. J Neurosurg
1990;73:429-435
Menon AG, Anderson KM, Riccardi VM, Chung RY, Whaley JM, Yandell DW, Farmer
GE, Freiman RN, Lee JK, Li FP, Barker DF, Ledbetter DH, Kleider A, Martuza RL,
Gusella JF, Seizinger BR. Chromosome 17p deletions and p53 gene mutations associated
with the formation of malignant neurofibrosarcomas in von Recklinghausen
neurofibromatosis. Proc Natl Acad Sci (USA) 1990; 87: 5435-5439
Steichen JD, Stewart RB, Louis DN, Choi BB, Kung R, Martuza RL. A new 1.9 micron
wavelength laser for neurosurgery. J Neurosurg 1990; 73:611-614
Louis DN, Hedley-Whyte TE, Martuza RL: Sarcomatous proliferation of the vasculature
in a subependymoma:a follow-up study of sarcomatous dedifferentiation. Acta Neuropath
1990; 80:573-574.
Jacoby LB, Hedley-Whyte ET, Pulaski K, Seizinger BR, Martuza RL. Clonal origin of
pituitary adenomas. J Neurosurg 1990; 73:731-735
Halliday AL, Sobel RA, Martuza RL. Benign spinal nerve sheath tumors: Their
occurrence sporadically and in neurofibromatosis 1 and 2. J Neurosurg 1991; 74:248-253.
Jacoby LB, Pulaski K, Rouleau GA, Martuza RL. Clonal analysis of human meningiomas
and schwannomas. Cancer Research 1990; 50:6783-6786.
Chiocca EA, Choi BB, Cai W, DeLuca NA, Schaffer PA, DiFiglia M, Breakefield XO,
Martuza RL. Transfer and expression of the lacZ gene in rat brain neurons mediated by
herpes simplex virus mutants. The New Biologist 1990; 2:739-746.
Fontaine B, Rouleau GA, Seizinger BR, Jewell AF, Hanson MP, Martuza RL, Gusella JF.
Equal parental origin of chromosome 22 losses in human sporadic meningioma: no
evidence for genomic imprinting. Amer J Hum Genetics 1990; 47:823-827
Short MP, Choi BB, Lee J-K, Malick A, Breakefield XO, Martuza RL. Gene delivery to
glioma cells in rat brain by grafting of a retrovirus packaging cell line. J Neurosci Res
1990; 27:427-433.
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Steichen JD, Weiss MJ, Elmaleh DR, Martuza RL. Enhanced in vitro uptake and retention
of a lipophilic cationic compound, 3H-tetraphenylphosphonium, by nervous system tumor
cells. J Neurosurg 1991; 74:116-122.
Fontaine B, Hanson MP, VonSattel JP, Martuza RL, Gusella JF. Loss of chromosome 22
alleles in human sporadic spinal schwannomas. Ann Neurol 1991; 29:183-186.
Flexon PB, Nadol JB Jr., Schuknecht HF, Montgomery WW, Martuza RL. Bialteral
acoustic neurofibromatosis (neurofibromatosis 2): a distinct disorder from Von
Recklinghausen's neurofibromatosis (neurofibromatosis 1). Ann Otol Rhinol
Laryngol 1991: 830-834.
Seizinger BR, Smith DI, Filling-Katz MR....Martuza RL, Gusella JF, Haines JL. Genetic
flanking markers refine diagnostic criteria and provide new insights into the genetics of
von Hippel Lindau disease. Proc Natl Acad Sci 1991; 88:2864-2868.
Jenike MA, Baer L, Ballantine HT, Martuza RL, Tynes S, Giriunas I, Buttolph L, Cassem
NH. Cingulotomy for refractory obsessive-compulsive disorder: a long-term follow-up of
33 patients. Archives of General Psychiatry 1991; 48: 548-555
Ezzedine ZD, Martuza RL, Short MP, Platika D, Malick A, Choi B, Breakefield XO.
Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes
simplex virus thymidine kinase gene. The New Biologist 1991; 23:608-614
Martuza RL, Malick A, Markert JM, Ruffner KL, Coen DM. Experimental therapy of
human glioma by means of a genetically engineered virus mutant. Science 1991; 252:
854-856.
Chung RY, Whaley JM, Klei N, Anderson KM, Louis D, Menon A, Hettlich C, Freiman R,
Hedley-Whyte ET, Martuza RL, Jenkins R, Yandell DW, Seizinger BR. TP53 gene
mutations and 17p deletions in human astrocytomas. Genes, Chromosomes, and Cancer
1991; 3:323-331
Fontaine B, Sanson M, Delattre O, Menon AG, Rouleau GA, Seizinger BR, Jewell AF,
Hanson MP, Aurius A, Martuza RL, et al. Parental origin of chromosome 22 loss in
sporadic NF2 neuromas. Genomics 1991; 10:280-3
Martuza RL. Molecular Neurosurgery for Glial and Neuronal Disorders. Stereotact Funct
Neurosurg 1992; 59:92-99
Huang Q, Vonsattel J-P, Schaffer PA, Martuza RL, Breakefield XO, DiFiglia M.
Introduction of a foreign gene (Escherichia Coli lacZ) into rat neostriatal neurons using
herpes simplex virus mutants: a light and electron microscopic study. Exp. Neurol. 1992;
115:303-316.
Poon WS, Schomacker KT, Deutsch TF, Martuza RL. Laser-induced fluorescence (LIF):
for intraoperative delineation of tumor resection margins. J Neurosurg 1992; 76:679-686
Lee JK, Sobel RA, Chiocca EA, Kim TS, Martuza RL. Growth of human acoustic
neuromas, neurofibromas, and Schwannomas in the subrenal capsule and sciatic nerve of
the nude mouse. J Neuro-Oncology 1992; 14:101-112
Narod SA, Parry D, Parboosingh J, Lenoir GM, Ruttledge M, Fischer G, Eldridge R,
Martuza RL, Frontali M, Haines J, Gusella JF, Rouleau GA. Neurofibromatosis type 2
appears to be a genetically homogenous disease. Amer J Human Genetics 1992; 51: 486496
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Markert J, Coen DM, Malick A, Mineta T, Martuza RL. Expanded spectrum of viral
therapy in the treatment of nervous system tumors. J Neurosurgery 1992; 77:590-594
Takamiya Y, Short MP, Ezzedine ZD, Moolten FL, Breakefield XO, Martuza RL. Gene
therapy of malignant brain tumors: a rat glioma line bearing the herpes simplex virus type1 thymidine kinase gene and wild type retrovirus kills other tumor cells. J Neuroscience
Res. 1992;33: 493-503
Nadol JB, Chiong CM, Ojemann RG, McKenna MJ, Martuza RL, Montgomery WW,
Levine RA, Ronner SF, Glynn RJ. Preservation of hearing and facial nerve function in
resection of acoustic neuroma. Laryngoscope 1992; 102:1153-1158.
Von Deimling A, Louis DN, Von Ammon K, Petersen I, Hoell T, Chung RY, Martuza RL,
Schoenfield DA, Yasargil MG, Wiestler OD, et al. Association of epidermal growth
factor receptor gene amplification with loss of chromosome 10 in human glioblastoma
multiorme. J Neurosurg 1992; 77:295-301.
Takamiya Y, Friedlander RM, Brem H, Malick A, Martuza RL. Inhibition of angiogenesis
and growth of human nerve sheath tumors by AGM-1470, a novel angiogenesis inhibitor. J
Neurosurgery 1993; 78:470-476.
Markert JM, Malick A, Coen DM, Martuza RL. Reduction and elimination of encephalitis
in an experimental glioma therapy model using attenuated herpes simplex mutants that
retain susceptibility to acyclovir. Neurosurgery 1993;32: 597-603.
Trofatter, JA, MacCollin MM, Rutter JL...Martuza RL...Gusella JF. A novel Moesin-,
Ezrin-, Radixin-like gene is a candidate for the Neurofibromatosis 2 tumor suppressor.
Cell 1993; 72:791-800.
Takamiya Y, Short MP, Moolten FL, Fleet C, Mineta T, Breakefield XO, Martuza RL. An
experimental model of retrovirus gene therapy for malignant brain tumors. J Neurosurg
1993; 79:104-110.
Yu JS, Martuza RL, Tepper RI. Treatment of glioma with genetically engineered
interleukin-4 secreting cells. Cancer Research 1993; 53:3152-3128.
Baer L, Rauch SL, Jenike MA, Cassem NH, Ballantine TB, Manzo PA, Martuza, RL.
Cingulotomy in a case of concomitant obsessive-compulsive disorder and Tourette's
syndrome. Archives General Psychiatry 51:1994, 73-74.
Takamiya Y, Brem H, Ojeifo J, Mineta T, Martuza RL. AGM-1470 inhibits the growth of
human glioblastoma cells in vitro and in vivo. Neurosurgery, 1994; 34:1-7.
Ahmad S, Mineta T, Martuza RL, Glazer RI. Antisense expression of protein kinase C(a)
inhibits the growth and tumorigenicity of human glioblastoma cells. Neurosurgery,
1994; 35:904-909.
Mineta T, Rabkin SD, Martuza RL. Treatment of malignant gliomas using ganciclovir
hypersensitive, ribonucleotide reductase deficient herpes simplex viral mutant.
Cancer Research, 1994; 54:3963-3966.
Al-Nabulsi I, Takamiya Y, Voloshin Y, Dritschilo A, Martuza RL, Jorgensen TJ.
Expression of thymidine kinase is essential to low dose radiation resistance of rat glioma
cells. Cancer Res 1994; 54:5614-5617.
Yazaki T, Takamiya Y, Costello P, Mineta T, Menon A, Rabkin SD,
Martuza RL. Inhibition of angiogenesis and growth of human non-malignant and malignant
meningiomas by TNP-470. J Neuro-oncology 1995; 23 :23-29.
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Mineta T, Yazaki T, Hunter W, Rabkin SD, Martuza RL. Attenuated multi-mutated
Herpes simplex virus-1 for the treatment of malignant gliomas. Nature Medicine, 1995;
1:938-943.
Yazaki T, Manz HJ, Rabkin SD, Martuza RL. Treatment of human malignant
meningiomas by G207, a replication-competent multimutated herpes simplex virus-1.
Cancer Research, 1995; 4752-4756.
Baer L, Rauch SL, Ballantine HT Jr., Martuza RL, Cosgrove R, Cassem E, Giriunas I,
Manzo PA, Dimino C, Jenike MA. Cingulotomy for intractable obsessive-compulsive
disorder. Prospective long-term follow-up of 18 patients. Arch Gen Psychiatry
1995, 52:384-392,
Yazaki T, Ahmad S, Chahlavi A, Zylber-Katz E, Dean NM, Rabkin SD, Martuza RL,
Glazer RI. Treatment of the glioblastoma U-87 by systemic administration of antisense
protein kinase C-alpha phosphorothiate oligonucleotide. Molecular Pharmacology 1996,
50: 236-242,.
Yazaki T, Martuza RL, Rabkin SD. Expression of L1 in primary astrocytes via a defective
herpes simplex outgrowth and neural cell migration. Molecular Brain Research 1996,
43:311-320.
Miyatake S-I, Martuza RL, Rabkin SD. Defective herpes simplex virus vectors expressing
thymidine kinase for the treatment of malignant glioma. Cancer Gene Therapy 1997,
4:222-228.
Miyatake S-I, Iyer A, Martuza RL, Rabkin SD. Transcriptional targeting of herpes simplex
virus for cell-specific replication. J. Virology 1997, 71:5124-5132.
Menon AG, Rutter JL, von Sattel JP, Snyder H, Murdock C, Blumenfeld A, Martuza RL,
von Deimling A, Gusella JF, Houseal TW. Frequent loss of chromosome 14 in atypical and
malignant meningioma: identification of a putative tumor progression locus.
Oncogene 1997, 14/15:611-616.
Toda M, Martuza RL, Kojima H, Rabkin SD. In situ cancer vaccination: An Il-12
defective vector/replication-competent herpes simplex virus combination induces local and
systemic antitumor immunity. J Immunol. 1998, 160:4457-4464.
Toda M, Rabkin SD, Martuza RL. Treatment of human breast cancer in a brain metastatic
model by G207, a replication-competent multimutated herpes simplex virus 1. Human
Gene Therapy 1998, 9:2177-2185.
New KC, Gale K, Martuza RL, Rabkin SD. Novel synthesis and release of GABA in
cerebellar granule cell cultures after infection with defective herpes simplex virus vectors
expressing glutamic acid decarboxylase. Molecular Brain Research 1998, 61:121-135.
Miyatake S-I, Tani S, Feigenbaum F, Sundaresan P, Toda H, Narumi O, Kikuchi H,
Hashimoto N, Hangai M, Martuza RL, Rabkin SD. Hepatoma-specific anti-tumor activity
of an albumin enhancer/promoter regulated herpes simplex virus in vivo. 1999, Gene
Therapy 6:564-572.
Toda M, Rabkin SD, Kojima H, Martuza RL. Herpes simplex as an “in situ cancer
vaccine” for the induction of specific antitumor immunity. Human Gene Therapy
1999,10:385-393.
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Chalavi A, Todo T, Martuza RL, Rabkin SD. Replication-competent herpes simplex virus
vector G207/cisplatin combination therapy for head and neck squamous cell carcinoma.
Neoplasia 1999, 1:162-169.
Hunter WD, Martuza RL, Feigenbaum F, Todo T, Mineta T, Yazaki T, Toda M, Newsome
JT, Platenberg RC, Manz HJ, Rabkin SD. Attenuated, replication-competent, herpes
simplex virus type-1 mutant G207: Safety evaluation of intracerebral injection in nonhuman primates. 1999, J. Virology 73:6319-6326.
Mashour GA, Caball-Manzano R, Wang H-L, Wellstein A, Martuza RL, Kurtz A. Aberrant
cutaneous expression of the angiogenic factor midkine is associated with neurofibromatosis
type-1. J. Investigative Dermatology 1999, 113(3): 398-402.
Chalavi A, Rabkin SD, Todo T, Sundaresan P, Martuza RL. Effect of prior exposure to
HSV-1 on viral vector mediated tumor therapy in immunocompetent mice.1999, Gene
Therapy 6: 1751-1758
Walker JR, McGeagh K, Sundaresan P, Jorgensen TJ, Rabkin SD, Martuza RL. Local and
systemic therapy of human prostate cancer with the conditionally replicating herpes simplex
virus vector G207. Human Gene Therapy 10:2237-2245, 1999
Todo T, Rabkin SD, Sundaresan P, Wu A, Meehan KR, Herscowitz HB, Martuza RL.
Systemic antitumor immunity in experimental brain tumor therapy using a multimutated,
replication-competent herpes simplex virus. Human Gene Therapy 10: 2741-2755, 1999
Todo T, Rabkin SD, Chalavi A, Martuza RL. Corticosteroid administration does not affect
viral oncolytic activity, but inhibits antitumor immunity in replication-competent herpes
simplex virus tumor therapy. Human Gene Therapy 10: 2869-2878, 1999
Mashour GA, Martuza RL, Kurtz A. Topical application of dimethylbenzanthracene to
neurofibromin-deficient mice induces abnormal melanogenesis. J Invest Dermatology
1999, 202:1133-1134.
Sandhu FA, Schellinger D, Martuza RL. A vascular extra-axial neurosarcoid mass mistaken
for a convexity meningioma. Diagnostic Neuroradiology 2000, 42: 195-198
Sandhu FA, Martuza RL. Craniofacial hemangiopericytoma associated with oncogenic
osteomalacia: Case report. J Neuro-oncology 2000, 46(3): 241-247.
Sundaresan P, Hunter WD, Martuza RL, Rabkin SD. Attenuated, replication-competent
herpes simplex virus type 1 mutant G207: Safety evaluation in mice. J Virology 2000,74:
3832-3841.
Moulding HD, Martuza RL, Rabkin SD. Clinical mutations in the L1 neural cell adhesion
molecule affect cell-surface expression. J Neuroscience 20(14):5696-5702, 2000
Markert, JM, Medlock, MD, Rabkin, SD, Gillespie, GY, Todo, T., Hunter, WD, Palmer,
CA, Feigenbaum, F., Tornatore, C., Tufaro, F. and Matuza, RL. Conditionally replicating
herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase
I trial. Gene Therapy 2000, 7: 867-874.
Todo, T., Feigenbaum, F., Rabkin, SD, Lakeman, F., Newsome, JT, Johnson, PA, Mitchell,
E., Belliveau, D., Ostrove, JM and Martuza, RL. Viral shedding and biodistribution of
G207, a multimutated, conditionally-replicating herpes simplex virus type 1, after
intracerebral inoculation in Aotus. Molecular Therapy 2000, 2(6): 588-595.
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110. Toda, M., Martuza, RL and Rabkin, SD. Tumor Growth Inhibition by Intratumoral
Inoculation of Defective Herpes Simplex Virus Vectors Expressing GranulocyteMacrophage Colony-Stimulating Factor. Molecular Therapy 2000, 2(4): 324-329.
111. Todo, T., Martuza, RL, Dallman, MJ and Rabkin, SD. In Situ Expression of Soluble B7-1
in the Context of Oncolytic Herpes Simplex Virus Induces Potent Antitumor Immunity.
Cancer Research 2000, 61: 153-161.
112. Toda M., Martuza RL & Rabkin SD. Combination suicide/cytokine gene therapy as
adjuvants to a defective herpes simplex virus-based cancer vaccine. Gene Therapy, 2001,
8: 332-339.
113. Varghese S., Newsome JT, Rabkin SD, McGeagh K., Mahoney D., Nielsen P., Todo T. and
Martuza RL. Preclinical Safety Evaluation of G207, a Replication-Competent Herpes
Simplex Virus Type I, Inoculated Intraprostatically in Mice and Nonhuman Primates.
Human Gene Therapy, 2001, 12: 999-1010.
114. Todo T., Martuza RL, Rabkin SD and Johnson PA. Oncolytic herpes simplex virus vector
with enhanced MHC class I presentation and tumor cell killing. Proc of National
Association of Science 2001, 98 (11): 6396-6401.
115. Jorgeson TJ, Katz S., Varghese S., Rabkin SD and Martuza RL Ionizing radiation does not
alter the antitumor activity of herpes simplex virus vector G207 in subcutaneous models of
human and murine prostate cancer, 2001, MS No. 01-187, Version 2. Neoplasia Vol 3
Issue 5 451-456.
116. Wu Aiguo, Mazumber Amitabha, Martuza Robert L., Liu Xia, Thein Myint, Meehan
Kenneth R., Rabkin Samuel D., Biological Pursing of Breast Cancer Cells Using an
Attenuated Replication-competent Herpes Simplex Virus in Human Hematopoietic Stem
Cell Transplantation. Cancer Research 2001, 61: 3009-3015.
Books, Chapters, Monographs, Reviews, Other Publications
l.
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Martuza RL, Ojemann RG. Intracranial Neoplasms. In Current Diagnosis. HF Conn and
RB Conn Jr, eds. WB Saunders, Co, Philadelphia WB Saunders, l980; pp 895-902.13.
Martuza RL. Neurofibromatosis: Neurological and Neurosurgical Considerations.
Neurology and Neurosurgery Update Series. Continuing Professional Education Center,
Inc. l982, Lesson 38 Vol 3.
Martuza, RL. Genetics in neuro-oncology. Clin Neurosurg 1983; 31:4l7-440.
Martuza RL. Neurofibromatosis and Other Phakomatoses. In Neurosurgery, RH Wilkins
and SS Rengachary (Eds.) McGraw-Hill Book Co. NY, 1984, Vol ll Chap 55, pp 511-521.
Martuza RL. Genetic Factors in Brain Tumors. In Neurosurgery, RH Wilkins and SS
Rengachary (Eds.) McGraw-Hill Book Co. NY 1984, Vol II, Chap 54 pp 505-5ll.
Martuza RL, Parker SW, Nadol JB Jr, Davis KR, Ojemann RG. Diagnosis of
cerebellopontine angle tumors. Clin Neurosurg l985; 32:l77-2l3.
Martuza RL, Aquino T. Trauma. In Manual of Neurologic Therapeutics (3rd ed.) l985,
Martin A Samuels (ed.), Little, Brown, Co. Boston, MA
Martuza RL, Seizinger BR, Jacoby LB, Rouleau GA and Gusella JF. The molecular biology
of human glial tumors. TINS l988; Vol. ll, No.l.
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Martuza RL, Eldridge, R: Neurofibromatosis 2 (Bilateral Acoustic Neurofibromatosis).
New Engl J Med l988; 318:684-688
Martuza RL. Neurosurgical Aspects of Neurofibromatosis In Neurofibromatosis. In A
Handbook for Patients, Families, and Health Care Professionals. A. Rubenstein and B. Korf
(eds) Thieme-Stratton Pub. Co.,
Ojemann RG, Martuza RL. Acoustic neuroma. In Neurological Surgery; 3rd edition. J.
Youmans (ed). WB Saunders Co., Phila. 1990, chapter 113; pp3316-3350.
Chiocca EA and Martuza RL. Neurosurgical Therapy of the Obsessive-Compulsive
Disorder. In Obsessive Compulsive Disorders: Theory and Management, 2nd edition. M.
Jenike, L. Baer, W. E. Minichiello (eds.) Year Book Medical Publishers, Inc. Chicago, 1990.
Fontaine B, Rouleau GA, Seizinger BS, Menon AG, Je.
well AF, Martuza RL, Gusella JF. Molecular genetics of neurofibromatosis 2 and related
tumors (acoustic neuroma and meningioma). Ann NY Acad Sci 1990; 615: 338-343.
Martuza RL and Rouleau G. Genetic Aspects of Neurosurgical Problems. In Neurological
Surgery, 3rd edition. J. Youmans (ed). WB Saunders Co., Phila. 1990, chapter 38;
pp1061-1080.
Steichen JD, Martuza RL. Trauma. In Manual of Neurologic Therapeutics (4th ed.) l990,
Martin A Samuels (ed) Little, Brown, Co. Boston, MA
Eldridge R, Martuza RL, Parry DM. Neurofibromatosis 2. In Current Therapy in Neurologic
Disease. R. T. Johnson (ed.) B.C. Decker Inc., Philadelphia, 1990
Martuza RL, Chiocca EA, Jenike MA, Giriunas I, Ballantine HT. Stereotactic
radiofrequency thermal cingulotomy for obsessive-compulsive disorder. J Neuropsychiatry
and Clinical Neurosciences 1990; 2:331-335.
Martuza RL. Neurofibromatosis as a Model for Tumor Formation in the Human Nervous
System. Neurobiology of Brain Tumors. Concepts in Neurosurgery, 1991. vol. 4, 53-62.
Gusella JF, Seizinger BR, Rouseau G, Menon A, Fontaine B, Martuza RL. Molecular
genetic analysis of the phakomatoses. In Molecular Mechanisms and Their Clinical
Applications in Malignancies. Academic Press, Inc. 1991
Martuza RL. Pathogenesis and treatment of nervous system tumors in NF2. in Tuberous
sclerosis and Neurofibromatosis: Epidemiology, Pathophysiology, Biology and Management.
Ishibashi Y and Hori E (eds.) Elsevier Science Publishers B.V., Amsterdam, 1991
Martuza RL. Genetic alterations of nervous system tumors. in Biologic Aspects of Brain
Tumors, Tabuchi (ed.), Springer-Verlag Inc. Tokyo, 1991 pp. 18-27
Short MP, Martuza RL. Clinical and genetic aspects of NF2: clinical features, family
studies, counseling and management issues. in Neurofibromatosis, Hughes RAC and Huson
S. (eds.) Chapman and Hall Ltd, London, 1991.
Martuza RL. Viral Vectors for Experimental Brain Tumor Therapy in "Molecular
Genetics of Nervous System Tumors". Levine A and Schmidek H (eds.) pp. 381-386
Sampson JH, Martuza RL. Genetic Factors in Brain Tumors.
Chapter 69, In Neurosurgery, RH Wilkins and SS Rengachary (Eds.)
McGraw-Hill Book Co. NY
Sampson JH, Martuza RL. Neurofibromatosis and other Phakomatoses. In Neurosurgery,
RH Wilkins and SS Rengachary (Eds.) McGraw-Hill Book Co. NY, Chapter 70.
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35.
36.
37.
38.
39.
40.
Proctor MR, Martuza RL. Trauma. In Manual of Neurologic
Therapeutics (5th ed.) l994, Martin A Samuels (ed) Little, Brown, Co. Boston, MA
Chiocca EA, Andersen JK, Takamiya Y, Martuza RL, Breakefield XO. Virus-mediated
genetic treatment of rodent gliomas, in Wolff JA (ed.) Gene Therapeutics, Boston,
Birkhauser Publishers, 1994, pp. 245-263
Baer L, Rauch AL, Ballantine HT, Jr., Martuza RL, Cosgrove R, et al. Cingulotomy
for intractable obsessive-compulsive disorder: prospective long-term follow-up of 18
patients. Archives of General Psychiatry (Letter) 1994; 51:73-74
Hunter W, Rabkin S, Martuza. Brain Tumor Therapy using
genetically engineered replication competent virus. In Viral Vectors, Kaplitt MG
Loewy AD (eds.), 1995, pp 259-274, Academic Press, Inc., San Diego
Viola JJ, Martuza RL. Gene therapies for glioblastomas. In Balliere’s Clinical Neurology,
Cerebral Gliomas, Yung WKA (ed.) 1996, pp 413-424
Hunter W, Yazaki T, Rabkin SD, Martuza RL. Replication-competent viral therapy of
tumors of the central nervous system. In Protocols for Gene Transfer in Neuroscience:
Towards Gene Therapy of Neurological Disorders. Lowenstein P and Enquist (eds.)
Wiley and Sons Ltd. 1996, pp 305-317
Martuza RL. Act locally, think globally. Nature Medicine 1997, 12:1323.
Lin T T-S, Martuza RL. Neurofibromatosis and other dysgenetic disorders. Handbook
of Clinical Neurology, vol 24 (68): Neuro-Oncology, Part II. Vecht Ch.J (ed.) Elsevier
Science B.V. 1997
Baidas S, Martuza RL. Tumors of the brain and spinal cord. Encyclopedia of
Neuroscience. Elsevier Science. 1998
Martuza RL, Coumans J-V CE. Trauma: Severe head Injury, Spinal Cord Injury.
Chapter 12, In Manual of Neurologic Therapeutics (6th ed.), Martin A Samuels (ed)
Lippincott Williams & Wilkins, Philadelphia, PA, l999, pp. 285-314
Lin T, Martuza RL. Gliomas in neurofibromatosis and other phakomatoses.
In The Gliomas, Berger MS, Wilson C. (eds.),W.B. Saunders Co., Phila., PA, 1999,
pp. 15-24
Feigenbaum F, Manz HJ, Platenberg LC, Martuza RL. Primary Intrinsic Tumors of the
Brain. In Principles of Neurosurgery, Grossman RG and CM Loftus (eds.), LippincottRaven Publishers, Phila.1999, pp.469-520
Hunter WD, Martuza RL. Meningioma. Encyclopedia of Neuroscience. Elsevier Science.
1999.
Martuza RL. Conditionally-replicating herpes vectors for cancer therapy. J Clin Invest,
105: 841-846, 2000;
Kirn, D., Martuza RL & Zwiebel J. Replication-selective virotherapy for cancer:
Biological principles, risk management and future directions. Nature Medicine 2001; Vol.
7, Num 7: 781-787.
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