Supplementary Figure 3: Neuronal location distribution within the STN by
group. The distribution of the different neuronal types is plotted along the dorsoventral axis. This is the main axis of interest according to physiological studies which
have shown that the dorsal part is the sensory-motor part of the STN (Parent and
Hazrati 1995; Nambu et al. 1996). Each neuron’s location is normalized to its relative
location between the STN dorsal entry point (set to 0) and the ventral exit point (set to
1) defined by the expert neurophysiologist for that trajectory (e.g. a neuron recorded
exactly between the entry and exit points of the STN would be assigned a value of
0.5, regardless of STN thickness). General view of the distributions at 0.1 bins shows
a tendency of TFB, HFB and DFB neurons to localize in the dorsal half of the STN,
while the non-oscillatory neurons were broadly distributed along the axis (0.22±0.19,
0.27±0.15, 0.23±0.09 and 0.45±0.24, mean±SD for TFB, HFB, DFB and nonoscillatory neurons, respectively). Mann-Whitney U-test was calculated for all groups
to test whether these distributions had significant difference in medians. TFB, HFB
and DFB groups were not significantly different from each other (p>0.1), while each
of their medians was found to be significantly different from the non-oscillatory group
(p<0.001). These results place TFBs, HFBs and DFBs mainly in the sensory-motor
area of the STN, providing more support for their involvement in the motor symptoms
of PD.
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