Documentation of Production: Allied Medical Publication 8 Planning Guide for the Estimation of Battle Casualties (Chemical) Carl Curling Julia Burr Lusine Danakian Deena Disraelly James Colin McGee July 2005 CONTENTS PREFACE ........................................................................................................................... iii I. INTRODUCTION .................................................................................................... 1 A. AMedP-8 DOCUMENTATION OBJECTIVES ................................................................ 1 B. AMedP-8 PURPOSE, CONCEPT, AND ASSUMPTIONS .............................................. 1 C. AMedP-8 HISTORY .......................................................................................................... 3 D. AMedP-8 REVISION TIMELINES................................................................................... 4 II. EVOLUTION AND OVERVIEW OF AMedP-8 CHEMICAL ..................................... 6 A. AMedP-8 CHEMICAL DERIVES FROM AMedP-8 NUCLEAR .................................... 6 1. Tactical Scenarios............................................................................................................... 6 2. Attack Details ..................................................................................................................... 7 3. Methodology ...................................................................................................................... 7 4. Presentation Format ............................................................................................................ 7 B. INPUTS AND ASSUMPTIONS SPECIFIC TO AMedP-8 CHEMICAL ......................... 8 1. Agents................................................................................................................................. 8 2. Munitions and Attack Intensities ........................................................................................ 9 3. Meteorology ....................................................................................................................... 9 4. Physical Protection ........................................................................................................... 10 5. Casualty Estimation Methodology ................................................................................... 11 III. CHEMICAL EXPOSURE ESTIMATION METHODOLOGY ................................... 12 A. INPUTS FOR CHEMICAL EXPOSURE ESTIMATION .............................................. 12 1. Tactical Arrangement of Units on Battlefield .................................................................. 13 a. Heavy Brigade .................................................................................................................. 13 b. Support Brigade................................................................................................................ 17 c. Light Infantry Brigade ...................................................................................................... 17 2. Agent Data........................................................................................................................ 18 3. Delivery System and Munitions Data............................................................................... 18 4. Meteorological Data ......................................................................................................... 18 B. INTERMEDIATE CALCULATIONS ............................................................................. 19 1. Chemical Agent Clouds.................................................................................................... 19 2. Aimpoint Determination................................................................................................... 21 C. CALCULATION OF AGENT EXPOSURE ................................................................... 27 1. BioStrike Evaluation Mode .............................................................................................. 27 2. BioStrike Output Format .................................................................................................. 28 3. Post-processing of Protection Available Case Data ......................................................... 29 IV. CASUALTY ESTIMATION METHODOLOGY ...................................................... 31 A. CALCULATION OF EQUIVALENT DOSE .................................................................. 32 B. CORRELATION OF EXPOSURE TO INJURY SEVERITY CATEGORIES............... 33 1. Generating Injury Severity Category Tables .................................................................... 33 2. Determining Injury Severity Category ............................................................................. 39 V. CALCULATION OF POST-ATTACK PERFORMANCE CAPABILITY .................... 42 A. DETERMINING SIGN/SYMPTOM SEVERITY PROFILES .................................... 51 B. PHYSICAL EFFECTIVENESS AS A FUNCTION OF PERFORMANCE ............ Error! Bookmark not defined. C. GENERATION OF PERFORMANCE TABLES............................................................ 55 VI. A. B. VII. VIII. IX. A. B. X. REMAINING METHODOLOGICAL QUESTIONS ..................................................... 56 EXPOSURE RANGE SELECTION………………………………………………….…47 TABLE GENERATION…………………………………………………………………47 AMedP-8 CHEMICAL DOCUMENT APPEARANCE……………...…………………49 SUMMARY OF CASUALTIES BY SCENARIO………………………………………51 OBSERVATIONS AND CONCLUSIONS.……..………………………...….…...……55 RECOMMENDATIONS FOR FUTURE VERSIONS OF AMedP-8 CHEMICAL…....55 CONCLUSIONS.………………………………………………………………………..56 DEFINITIONS…………………………………………………...………………………58 APPENDICES A: B: C: D: E: F: G: H: I: J: K: L: M: Heavy Brigade, Forward Maneuver Battalion, Movement to Contact……........A-1 Heavy Brigade, Brigade Support Area, Movement to Contact….......................B-1 Heavy Brigade, Forward Maneuver Battalion, Offense……………..………......C-1 Heavy Brigade, Forward Maneuver Battalion, Defense……………..………....D-1 Heavy Brigade, Brigade Support Area, Offense and Defense………………….E-1 Support Brigade…………………....……………………………………............F-1 Light Infantry Brigade………………..................……………………….............G-1 TOE Information…………………………………….………………………….H-1 Data Processing…………...….…………………………………………….……I-1 Determination of Effective Dose ………………………..………………..…….J-1 Construction of Exposure Ranges…………………………………...………....K-1 Performance Factor Measures…………………..……...……………………….L-1 References………………………………………………...…………………....M-1 PREFACE I. A. INTRODUCTION AMedP-8 DOCUMENTATION OBJECTIVES This report provides a record of the production of Allied Medical Publication 8, Medical Planning Guide of NBC Battle Casualties, Volume III – Chemical (AMedP-8 Chemical), in a collaborative effort involving the Institute for Defense Analyses (IDA), Pacific-Sierra Research Corporation (PSR) and SAIC. The documentation herein discusses the development of AMedP-8, revealing its technical basis by focusing on underlying algorithms, assumptions, and data. B. AMedP-8 PURPOSE, CONCEPT, AND ASSUMPTIONS AMedP-8 is designed to estimate the numbers and types of patients resulting from the military use of nuclear, biological, or chemical weapons. AMedP-8 Chemical provides estimates of casualties and remaining operational strength after a single attack of either a persistent nerve agent, a non-persistent nerve agent, or a blister agent on a brigade-size unit during an out-of-area contingency operation. These estimates consist of the numbers, injury type, and injury severity of patients based on several brigade scenarios. The scenarios consist of single releases of chemical agents in the unit area of one of three different brigade-size units, with or without the availability of physical protection. AMedP-8 will find a target-audience across the full range of military personnel who use casualty estimates in planning and executing operations. The planning guide was envisioned as especially useful for crisis or contingency planning, where a chemical weapon attack is imminent or has occurred and rapid casualty estimation is necessary for response. For example, AMedP-8 will aid operational planners and commanders who must assess impact on mission, select courses of action, maintain awareness, and respond to changes in battle tempo; and personnel managers who must plan for replacements for killed or wounded in action (KIA, WIA), medical casualties, and/or those personnel whose performance is degraded to an extent that warrants replacement or augmentation. Additionally, it will prove useful for surgeons, medical planners, and logistics managers who must plan for—and respond to—sudden requirements for supplies (especially medical) of unusual types and numbers. AMedP-8 is meant to serve as a single reference that leads the user to a table or to a cell in a table that provides a supportable estimate of casualties resulting from the unique combination of units, mission, and weapon of interest. The assumptions made in the design 1 and development of this manual must be clearly understood to allow for proper use of the casualty estimation tables. The most significant of these assumptions are: Casualty estimates are based on scenarios consisting of brigade-sized units in tactical formations. Missions consist of out-of-area operations. Specifically, the terrain is modeled as a flat, open plain and troops are dispersed over relatively large areas. Urban, forested, or mountainous terrains are not considered. The chemical weapons are persistent nerve agent (VX), non-persistent nerve agent (GB), or blister agent (HD). The weapon delivery systems are aerial bombs, tactical ballistic missiles (TBMs), and rounds from multiple rocket launch systems/artillery batteries (MRLS/artillery). Submunitions and non-exploding munitions, such as aerosol generators and aerial spray tanks, are not considered. The attack intensities are characterized as light, moderate, or heavy. The optimization of aimpoints was designed to maximize the load on the medical system. Thus aimpoints were chosen to maximize the number of individuals with exposures causing injurious but less-than-lethal effects. All personnel are assumed to be engaged in extravehicular, unsheltered activities at the time of chemical attack, and have not been warned or prepared to expect a chemical attack. Only individual physical protection is considered, and two cases are addressed: protection unavailable and protection available. All personnel are trained to don individual protective equipment within a certain time limit; they don a protective mask and hood within one minute and an overgarment, overboots, and gloves within nine minutes. Worst-case conditions are also modeled for weather, defined as conditions that would give rise to agent concentrations greater than or equal to incapacitating levels distributed over the largest geographic area. Temperature, local attack time, wind speed, and cloud cover reflect the meteorology of Southwest Asia. Worst-case conditions may vary with type of agent and munitions. For example, atmospheric stability, wind speed, and/or temperature may affect agent persistence and/or exposure conditions. Precipitation is not considered; however, HD skin hazards are modeled for wet skin, which is associated with rain and/or warm temperatures and high relative humidity. Units are assumed to continue to execute their missions even after a chemical weapon attack. The operational tempo requires all but the most injured personnel to continue operations. An exposed individual must be significantly incapacitated to be evacuated for medical care. This leads directly to the definition of a “casualty.” The performance of an exposed individual must be degraded to less than or equal to 25% of original capability for him or her to be considered a casualty and enter the medical system. However, once an individual is 2 defined as a casualty, he or she must recover to at least 75% of original capability before he or she can leave the medical system and be considered “Returned to Duty” (RTD). C. AMedP-8 HISTORY The history of AMedP-8 Chemical begins with the development of AMedP-8 Nuclear. Although the current revision of AMedP-8 Nuclear was first conceived in 1992, its basis was established thirty years back with the publication of A System for Estimating the Medical Load in Nuclear Warfare on December 14, 1959 by the Walter Reed Army Institute of Research. This new methodology allowed the user to estimate, given the size of a unit and the yield and offset distance of a nuclear weapon, the fraction and types of injuries that would result. It assumed that personnel in the unit were uniformly distributed in an ellipse centered on the offset distance and of the same size as the unit area. At the time of publication, fewer than 15 years after Hiroshima, the casualty estimation methodology was classified SECRET, and only fifty copies were released. This eventually evolved into AMedP-8, which remained specifically nuclear until 1996. Thus, although chemical and biological weapons were a relatively old technology compared to nuclear weapons, it took most of the twentieth century to develop an adequate casualty estimation methodology that allowed for an internationally accepted doctrine. The year 1994 gave rise to the idea that the baseline methodology developed by the Defense Nuclear Agency’s Intermediate Dose Program (IDP)1 could be extended from nuclear effects to chemical and biological weapon effects. The Defense Nuclear Agency’s Improved Casualty Estimation (DICE)2 methodology extended the modeling of performance degradation from nuclear weapon effects to include the effects of chemical and biological weapons with one simplifying assumption and a limited amount of further research. The simplifying assumption is that performance degradation is similar for similar severities of a symptom, without regard to the causative agent for that symptom. Thus, nausea and vomiting are debilitating whether caused by overexposure to radiation, poisoning by a nerve agent, or bacterial illness. Given this assumption, all that remained was to define the symptoms resulting from chemical or biological exposure. Performance degradation from symptoms equivalent to those caused by nuclear weapons could now be directly calculated. For those symptoms with no nuclear equivalent, additional research along the lines of the IDP was required. 1 2 Anno et al., 1984 Deverill et al., 1994 3 This allowed the US to propose a new AMedP-8 revision in 1996: adding Biological and Chemical casualty estimation as volumes II and III to the Planning Guide for the Estimation of Battle Casualties, Volume I – Nuclear. These new documents built upon the concepts introduced with the new AMedP-8 Nuclear, expanded to include chemical and biological agents, appropriate delivery systems, and (in Volume II – Biological) additional tactical scenarios. The user of the manual, given some estimate of the types of agents and delivery systems to be used, and the type, posture, and mission of the military unit of interest, could estimate resulting casualties by injury type and time of onset, as well as estimate the performance capability of unit members as a function of time after exposure. D. AMedP-8 REVISION TIMELINES Revision and ratification of AMedP-8 is governed by the traditions and practices of the North Atlantic Treaty Organization (NATO). Within NATO, the Nuclear, Biological, and Chemical (NBC) Medical Working Group (NBCMedWG) is tasked with developing doctrine and procedures relevant to the medical protection and treatment of military personnel exposed to NBC agents. The NBC Defense Staff Officer of The US Army Office of the Surgeon General (OTSG) serves as the US Head of Delegation for the NBCMedWG and, as such, represents the US positions and interests. Outside of the regular meetings of the NBCMedWG, the United States also is Custodian of NATO Standardization Agreements (STANAGS) for the estimation of casualties resulting from the use of NBC weapons. The NATO Planning Guide for the Estimation of NBC Battle Casualties is presented in three volumes: Volume I – Nuclear (STANAG 2475), Volume II – Biological (STANAG 2476), and Volume III – Chemical (STANAG 2477). The Custodian is responsible for maintaining the STANAG in a current and relevant form and reviewing each document at least once every three years. Reviews are conducted formally in Custodial Meetings, sponsored by the Custodian and attended by all interested Allies. Revisions to the STANAGS are submitted in Study Drafts, which are circulated for comment among the Allies. Once general consensus has been reached that the revised STANAG is complete and correct, it is submitted as a Ratification Draft through the Secretary of the NBCMedWG to the NATO Army Board for distribution, review, implementation, and ratification. Ratification is approved and the STANAG is promulgated upon agreement by two-thirds (2/3) of the member nations that the STANAG will be implemented. The division of AMedP-8 into three STANAGs was part of the guidance, in 1996, of the NATO Army Board. The NBCMedWG was instructed to split AMedP-8 into three volumes, and publish nuclear, biological, and chemical casualty estimation in separate 4 STANAGs (2475, 2476, and 2477, respectively). The US, as Custodian, proposed AMedP-8 Chemical to NATO in 1996, followed by Study Draft 1 in 1997. Study Draft 2 followed rapidly on September 25, 1997, and Study Draft 3 was presented at the NBC Medical Working Group meeting in 1998. Final comments were solicited and integrated into the document: The Ratification Draft was distributed to the nations on September 10, 1998. By 2000, five nations (BE, GR, LU, TU, NL) had responded to the ratification request. Only one (NL) chose not to ratify. In 2001, five more nations had ratified (CZ, DA, IT, UK, US), but that was still one nation short of the requirement for promulgation. That requirement was met in 2002 when two more nations (CA, SP) ratified the document. AMedP-8 Chemical STANAG 2477 was promulgated on 25 April 2002. At this time (2004), a total of 12 nations (all above, plus GE) have ratified AMedP-8 Chemical. 5 II. EVOLUTION AND OVERVIEW OF AMedP-8 CHEMICAL The second of three planned volumes of AMedP-8 to be developed, the chemical volume incorporates the same underlying philosophy, approach, and format first established in the nuclear volume. Inherent differences between chemical and nuclear warfare warrant different assumptions, inputs, and analytical tools to estimate casualties. This section compares the assumptions, inputs, and methodology used in the nuclear and chemical volumes. A. AMedP-8 CHEMICAL DERIVES FROM AMedP-8 NUCLEAR Development of AMedP-8 Chemical was guided by the principle that it be as consistent as possible with AMedP-8 Nuclear. Thus, many of the inputs, assumptions, and formatting of AMedP-8 Nuclear have been adopted regarding tactical scenarios, attack details, casualty estimation methodology, and presentation format of estimates. 1. Tactical Scenarios AMedP-8 Chemical considers the same seven tactical scenarios as AMedP-8 Nuclear: Heavy Brigade, Forward Maneuver,3 Movement to Contact Heavy Brigade, Forward Maneuver, Offense Heavy Brigade, Forward Maneuver, Defense Heavy Brigade, Brigade Support Area, Movement to Contact Heavy Brigade, Brigade Support Area, Offense and Defense Light Infantry Brigade, Defense Support Brigade Units are configured as for an out-of-area operation. They are relatively dispersed and are assumed to be operating in flat, open terrain. Protection is available in both AMedP-8 Nuclear and Chemical. Although tactical scenarios contain vehicles, tents, and other forms of shelter, unlike AMedP-8 Nuclear, AMedP-8 Chemical disregards these forms of collective protection. Instead, it assumes that all targeted personnel are unsheltered, and individual protection is available. Similar to AMedP-8 Nuclear, AMedP-8 Chemical assumes that personnel do not receive pre-exposure prophylaxis or post-exposure treatment. “Forward Maneuver” and “Forward Maneuver Battalions” are used interchangeably in this document and its appendices. 3 6 2. Attack Details Casualty estimates presented in AMedP-8 Chemical are for single attacks occurring individually in a given scenario (similar to AMedP-8 Nuclear); however, it ventures further to consider attacks of varying intensity (light, moderate, heavy) for a given weapon type and scenario. Determination of aimpoints differs from AMedP-8 Nuclear; aimpoints are optimized to produce the greatest number of casualties entering the medical system within the targeted sub-operational area (battalion or brigade). Furthermore, casualty estimates include personnel located within both the targeted and downwind hazard areas of the operational area or brigade. Similar to AMedP-8 Nuclear, AMedP-8 Chemical presents “worst-case” casualty estimates. Thus, attack parameters are based on assumptions that maximize the number of casualties and the resulting workload for the medical system: the availability of individual physical protection is considered for all scenarios; personnel do not receive medical preexposure prophylaxis or post-exposure medical care; target locations are selected to maximize the number of personnel that are expected to enter the medical system as casualties; and, attacks occur under worst-case meteorological conditions. These assumptions are discussed further in Section II.B. 3. Methodology As in AMedP-8 Nuclear, AMedP-8 Chemical casualty estimates are derived from the evaluation of effects of single attacks against static troop formations. The estimates begin with calculation of the amount of agent to which individuals within the troop formation are exposed as a result of an attack. Then the effects of the attacks are characterized by the signs and symptoms experienced by individuals given their level of exposure, and the associated degradation of their performance over time. 4. Presentation Format As in AMedP-8 Nuclear, AMedP-8 Chemical provides estimates of the number of personnel with various types and severity of injury at specified times after exposure, the performance level of unit personnel over time, and the number of fatalities over time. To facilitate use of AMedP-8 Chemical, the organization and structure of AMedP-8 Nuclear was retained to the extent possible. The first three sections provide introductory and background material, an overview of the methodologies used, and a discussion of how to use the casualty tables presented in subsequent sections. The remaining sections provide casualty estimates, organized by tactical scenario. Each section in turn comprises subsections organized by agent and contains estimates for all munitions/attack intensity combinations. 7 B. INPUTS AND ASSUMPTIONS SPECIFIC TO AMedP-8 CHEMICAL Chemical warfare attacks differ from battlefield nuclear warfare attacks in several aspects. A wide variety of chemical agents can be used in warfare, each of which has unique dissemination characteristics and human effects. Most conventional munitions can be modified to deliver chemical agent, and the means of delivery will greatly influence the effects of the attack. Prevailing meteorological conditions will significantly influence the size of the area affected by the attack, the concentration of agent within the attack area, and the persistence of the attack over time. In developing AMedP-8 Chemical, agents, delivery systems, and attack intensities were chosen to represent the range of effects. Meteorological conditions were selected to maximize the effective attack area for a given agent/delivery system combination. Estimates consider two levels of protection: unavailable and available. 1. Agents AMedP-8 Chemical considers three agents: the persistent nerve agent VX, the nonpersistent nerve agent GB (also known as sarin), and the blister agent HD (also known as distilled mustard). Persistent chemical agents have low volatility and evaporate very slowly. Once disseminated, the bulk of the agent remains in liquid form, falling to the ground as droplets, where it will remain for extended periods of time. Exposure to the agent typically occurs through contact with the skin. Non-persistent agents are high-volatility chemicals, evaporating rapidly. Once disseminated, the bulk of agent is in gaseous form. Exposure to the agent typically occurs via inhalation of vapor, although chemicals can be absorbed through exposed skin and eyes as well. The primary physiological effect of nerve agents is the system-wide buildup of acetylcholine at nerve-nerve or nerve-muscle junctions, causing toxicity within minutes to hours after exposure. At lower doses, nerve agent exposure is associated with eye pain, blurred vision, headache, chest tightness, restricted breathing, nausea, and vomiting. At higher doses, nerve agent exposure is associated with tremors, convulsions, paralysis, respiratory failure, and death. Blister agents cause inflammation, blistering, and general tissue destruction, the locus and severity of which depend on the quantity and route of exposure. The blister agent considered here, HD, is of moderate volatility; its dissemination would result in significant 8 hazard from both liquid and vapor. Inhalation of HD vapor can damage the respiratory system, with symptoms ranging from nausea, dry cough, and sore throat at low doses to severe chest pain, choking, and death at high doses. Exposure to HD vapor or liquid will cause burning and swelling of the eyes, and blisters and ulceration of the skin. At high doses, whole body skin effects are very severe, leading to intoxication and death. 2. Munitions and Attack Intensities Most conventional explosive munitions can be modified to disseminate chemical agents. To represent the range of possible chemical warfare casualties, AMedP-8 Chemical considers a variety of munitions; for each type of munitions, it considers effects from light, moderate and heavy intensities of attack. Table II-1 summarizes the munitions and attack intensities considered in AMedP-8 Chemical. Further information on munitions and attack details can be found in Appendix I. Table II-1. Munitions and Attack Intensity Combinations Attack Intensity Munitions Artillery Bombs Missiles Light 152mm Artillery 18 rounds 250kg Bombs 2 rounds 250kg TBM 1 round Moderate 122mm Rockets 240 rounds 250kg Bombs 12 rounds 500kg TBM 2 rounds Heavy 122mm Rockets 720 rounds 250kg Bombs 24 rounds 500kg TBM 4 rounds 3. Meteorology The casualties resulting from any given chemical agent attack can vary significantly depending on the meteorological conditions prevailing at the time of attack. The casualty estimates presented in AMedP-8 Chemical assume worst-case meteorological conditions, defined as those that would result in agent concentrations greater than or equal to incapacitating levels distributed over the largest geographic area. The meteorological conditions that affect agent dissemination include temperature, cloud cover, atmospheric stability, and wind speed. The worst-case values for any of these conditions may vary by agent and delivery system because of differences in volatility, payload, height of burst, and area of impact. Therefore, the development of AMedP-8 Chemical required an assessment of worst-case meteorological conditions specific to the 9 agent/munitions/attack intensity combination considered. SAIC performed this assessment and their methodology was not available for documentation.4 Section III.A.4 describes input parameters for meteorology assessment. Appendix I.C.3 contains the meteorological data used for the production of AMedP-8 Chemical. 4. Physical Protection For each scenario, AMedP-8 provides casualty estimates for both protection unavailable and protection available cases. In all scenarios, personnel are assumed to be engaged in extra-vehicular activities and unsheltered at the time of attack. Furthermore, all personnel are assumed to be wearing standard battledress uniform at the initiation of attack. In the protection unavailable case, personnel are assumed to be exposed to the effects of agent through all possible routes of entry: skin, eyes, and respiratory tract. In the protection available case, AMedP-8 considers the use of individual protective equipment to mitigate or negate the effects of chemical agents. Individual protective equipment includes a protective mask and hood, overgarment, overboots, and gloves. Note that casualty estimates disregard the existence of collective protection, such as vehicles and tents. In the protection available case, it is assumed that immediately following the attack, all personnel don the mask within one minute and the full protective ensemble within nine minutes. Personnel are exposed to the agent through skin, eyes, and the respiratory tract; however, this exposure exists only for the time it takes to don a protective mask, assumed to be one minute. At this point, individuals are exposed only to the skin effects of agent until they don the rest of their protective equipment, a process that is assumed to take a total of nine minutes. Thus, respiratory exposures occur for one minute and body surface exposures continue for a total of nine minutes. The assumptions made about the time it takes to don protective equipment are derived from individual skill set standards and assume that all forces are trained to meet these standards. They are conservative estimates since they assume all personnel utilize the maximum amount of time to don equipment. If a soldier has ready access to his equipment, it may only take a few seconds to put on a mask and fewer than nine minutes to put on the rest of his ensemble. At the same time, these casualty estimates optimistically assume that protective equipment fits properly and provides complete protection, and that all soldiers 4 SAIC performed an assessment of worst-case meteorological conditions specific to the agent/munitions/attack intensity combinations considered in AMedP-8 Chemical. Thus, SAIC generated separate meteorological input files for each combination, and IDA used these values to develop chemical exposure estimates. Further information was not available in order to document the SAIC methodology. 10 have their equipment available and don it correctly. In addition, estimates don’t consider performance decrement not caused by the chemical agent, such as heat stress, fatigue, and visual decrement. On balance, these assumptions should provide reasonable approximation of the effects of protective equipment. 5. Casualty Estimation Methodology At the very general level, the methodology used to develop the chemical volume is the same as that used to develop the nuclear volume. From a specific combination of tactical unit and type of attack (threat agent, delivery system, and attack intensity), the levels of agent exposure among individuals within the unit are calculated. Given the set of individual exposures, the fates of individuals are then determined—if and when they become casualties, the nature and severity of their illnesses, the time over which they are ill, and whether they recover or die. These data are then tabulated to portray the number of casualties in the unit. Because attacks with nuclear and chemical weapons are quite different, however, the nuclear and chemical volumes of AMedP-8 used different analytical tools to calculate effects. In developing the chemical volume, the Naval Surface Warfare Center’s Vapor, Liquid, and Solid Tracking Model (VLSTRACK), version 1.6.1, was used to model the dispersion of chemical agent, in both liquid and vapor forms.5 The output of VLSTRACK was combined with a three-dimensional (x, y, and time) representation of a tactical unit within the BioStrike model developed by the Institute for Defense Analyses to determine individual agent exposures.6 These exposures were then input to the U.S. Defense Nuclear Agency Improved Casualty Estimation/Intermediate Dosage Program (DICE/IDP) 7 methodology to estimate casualty numbers, illness severity, and performance levels over time (see Section IV for a detailed discussion of this methodology). 5 Bauer, Timothy J. and Roger L. Gibbs, 1995. Flythe, 2000. The use of the BioStrike model requires agent dispersion data reported in a specific format; to streamline the methodology, IDA developed a variant of VLSTRACK, called GRIDGEN, to report the outputs of VLSTRACK in a BioStrike-compatible format. 7 McClellan et al., 1988. 6 11 III. CHEMICAL EXPOSURE ESTIMATION METHODOLOGY The casualty estimation approach used to develop AMedP-8 begins with determining agent exposure at the level of the individual or group of individuals (or icon, see below) based on their location within the scenario and with respect to the attack. This section describes the methodology used to estimate chemical exposure for icons in each scenario. Section IV goes on to discuss the methodology for using these exposure estimates to determine performance degradation and casualty estimates. Calculating agent exposure at the individual level for all scenarios considered in AMedP-8 Chemical requires various types of input data; some data are collected as basic inputs and some are calculated in intermediate steps. Figure III-1 describes the process by which individual agent exposures are calculated for the AMedP-8 Chemical; input data and output data are shown as boxes, while analytical tools are shown as ovals. A. INPUTS FOR CHEMICAL EXPOSURE ESTIMATION As shown in Figure III-1, several different types of information are required to calculate individual chemical agent exposures in any given scenario. These include information on the tactical arrangement of units on the battlefield (Troop Data), agent data, delivery system and munitions data (Munitions Data), and meteorological data. Attack Point Troop Data Meteorological Data Agent Data Munitions Data VLSTRACK (Gridgen) Biostrike Agent Cloud Exposure to Individuals Figure III-1. Calculating Individual Exposure Levels 12 1. Tactical Arrangement of Units on Battlefield AMedP-8 Chemical relies on scenario-based casualty estimation. Scenarios consist of a tactical arrangement of units on the battlefield, based on doctrinal composition.8 Within each scenario, the smallest tactical units or systems are called icons, each consisting of one or several personnel (or crew). The seven scenarios listed in Section II.A were used in AMedP8; each scenario has six subscenarios, or cases. A case is a combination of scenario, agent (GB, VX, or HD), attack intensity (heavy, moderate, or light), and posture (protection unavailable, or protection available). The scenarios are organized by brigade and are discussed in greater detail below. For each scenario, troop data files used as BioStrike inputs are further described in Appendix I. a. Heavy Brigade The Heavy Brigade consists of six battalions and other assigned elements. The battalions are two mechanized infantries, one armor, one self-propelled artillery, one mechanized engineer, and one support battalion. Assigned elements include air defense, intelligence, military police, and smoke generators. The Heavy Brigade is depicted performing three missions: movement to contact, offense and defense. The formation and separation among units and systems varies in each of the tactical missions. The Heavy Brigade personnel manning level used in this document is 4,042 personnel, which includes supporting units such as air defense. There are 443 armored vehicles, 778 wheeled vehicles (trucks), and 9 motorcycles. Of the armored vehicles, 76 are main battle tanks or their derivatives; the remainder are armored fighting vehicles, howitzers, mortar carriers, etc. Within the truck category, there are 252 light utility (equivalent to the US HMMWV), 224 5-ton cargo, and 144 8-ton cargo. In the scenarios described below, trucks predominate in the brigade support area and armored vehicles predominate in the maneuver area. All vehicle mixes in the targets were assigned as they would be in the appropriate combat situation. The area occupied by the Brigade is large relative to the area coverage of the chemical weapons. Additionally, casualty estimates do not account for protection provided by trucks and other vehicles; personnel are assumed to be unsheltered at the time of attack (see Section II.A). Casualties are estimated for different areas of the Brigade targeted: the maneuver battalions or the brigade support area. 8 Please see Appendix H for tables of organization and equipment (TOEs) referenced to develop the scenarios. 13 Maneuver battalions are targeted in the scenarios Heavy Brigade, Forward Maneuver, Movement to Contact Heavy Brigade, Forward Maneuver, Offense Heavy Brigade, Forward Maneuver, Defense The brigade support area is targeted in the scenarios Heavy Brigade, Brigade Support Area, Movement to Contact Heavy Brigade, Brigade Support Area, Offense and Defense The Heavy Brigade and its tactical scenarios are briefly described here; further details and relevant data can be found in Appendices A through E. Appendix A pertains to the “Heavy Brigade, Forward Maneuver, Movement to Contact” scenario. Table A1 describes the brigade, at the icon level of detail, in tactical arrangement; Table A2 provides similar information, arranged according to icon number. These tables display all icons in the heavy brigade and are not limited to those targeted in this scenario. Figure A-1 provides a tactical layout of these icons, labeled by task force; included are the Brigade Support Area, Mechanized Infantry Battalion 1, Mechanized Infantry Battalion 2, and the Tank Battalion Task Forces. The Forward Maneuver Task Forces are targeted for attack in the scenario “Heavy Brigade, Forward Maneuver, Movement to Contact,” while the Brigade Support Area Task Force is targeted in the scenario “Heavy Brigade, Brigade Support Area, Movement to Contact” (see Appendix B). The Tank Battalion Task Force is targeted in the scenarios “Heavy Brigade, Forward Maneuver, Offense” (see Appendix C), and “Heavy Brigade, Forward Maneuver, Defense” (see Appendix D), but the Brigade Support Area Task Force is targeted in the scenario “Heavy Brigade, Brigade Support Area, Offense and Defense” (see Appendix E). The process for determining aimpoints for attack is described in Section III.B.2. The tactical scenarios of the Heavy Brigade are detailed below. Heavy Brigade, Forward Maneuver, Movement to Contact The Brigade is deployed with two battalion task forces moving on line; the third task force follows, deployed on line across the width of the brigade (see Figure A-1). The support elements follow next. Scouts, ground surveillance radar, and some combat engineers are leading forward of the two task forces on line. The direct support artillery battalion has one battery traveling with each task force. The direct support engineer battalion has one company moving with each task force. Air defense and smoke generator assets are located 14 with each task force and the support formation. Within this formation, all companies and batteries are traveling deployed on line. Appendix A contains details on unit description and agent exposure effects for this scenario. Figures A2 and A3 present the tactical layout of the forward maneuver battalions targeted in this scenario. Heavy Brigade, Forward Maneuver, Offense The Heavy Brigade in the offense comprises three battalion task forces on line and a brigade support area. This array presents four basic target areas (three battalion task forces with support and a brigade support area), three of which are essentially identical. The battalions are well-dispersed and present individual targets within the brigade area. Thus, the detailed casualty assessment is presented for a battalion task force and the brigade support area. Figures C1 and C2 are schematics of the unit deployment. The maneuver force target comprises three company teams on line, with scouts on both flanks. Behind the teams, the battalion mortars are deployed in two sections. A direct support artillery battery is deployed in three groups — two firing platoons and a battery headquarters. An engineer company is also in direct support. The majority of the engineers are maintained in the company formation. The battalion retains a reserve company team and a separate combat trains area. There is a main battalion command post and a tactical command post. The tactical command post is more forward. The battalion anti-armor company is divided among the reserve, center, and right flank teams as anti-armor platoons. Air defense and smoke generator assets are integrated into elements of the formation. Appendix C contains detailed unit descriptions and agent exposure estimates for this scenario. Heavy Brigade, Forward Maneuver, Defense As deployed for the defense, the Brigade again provides four elements that may be targeted: three battalion task forces and a brigade support area; a battalion-size reserve is not maintained in this situation. As discussed above, this layout provides two basic formations for casualty estimation, targeting a maneuver unit or the brigade support area. The maneuver unit is described here and a schematic is provided in Figure D-1; the brigade support area is described below. In the defense, company teams are not formed; therefore, the armor company is maintained. The battalion is deployed with scouts and ground surveillance radars forward of the main defensive positions. Four companies are deployed on line and one is maintained in reserve. The anti-armor company is not attached out but employed as one of the companies in the main defensive position. The armor company is designated as the reserve. The direct support artillery battery is deployed as two platoons with the battery 15 headquarters collocated with one of the platoons. The battalion mortar platoon is divided into two sections. There is a main command post, a tactical battalion command post, a combat train area, and a combat engineer company. Air defense and smoke generator assets are integrated into elements of the formation. Appendix D contains details on unit description and chemical agent exposure estimates for icons in this scenario. Heavy Brigade, Brigade Support Area, Movement to Contact In movement to contact, elements that constitute the brigade support area are moving in convoy behind the third task force of the brigade, as shown in Figure B-1. These elements consist of the brigade support battalion, the logistical elements of all the maneuver battalions, the brigade main command post, and the support battalion command post. Air defense assets are integrated into the formation. Most of the units are deployed in multiple parallel columns. Appendix B contains details on unit description and agent exposure estimates for the Heavy Brigade, Brigade Support Area, Movement to Contact. Note that corresponding icons (in terms of function) are assigned different icon numbers in movement to contact, compared to offense and defense. Heavy Brigade, Brigade Support Area, Offense and Defense The brigade support area was assumed to be the same for both the offense and defense missions. The support area is established along a supply route and units are deployed as shown in Figure E-1. The bold outline in these figures indicates the unit boundaries. The support area units include logistical elements for food, maintenance, supply, limited ammunition, transportation, and medical. Also located in the brigade support area are logistical elements of the brigade’s organic maneuver battalions. These are two mechanized infantry, one armor, one mechanized engineer, and one self-propelled artillery battalions. The brigade rear headquarters and support battalion headquarters are also located here. An air defense platoon and company headquarters provide point defense from air attack. Appendix E contains details on unit description and agent exposure estimates, for the Heavy Brigade, Brigade Support Area, in Offense and Defense. Note that corresponding icons (in terms of function) are assigned different icon numbers in Movement to Contact, compared to Offense and Defense. 16 b. Support Brigade The Support Brigade is patterned after a combat service support formation that could support at least one heavy division. The units are stationary and deployed along a main supply route (see Figure F-1). Units included are: Supply and Service Company Heavy Maintenance Company Light Maintenance Company Missile Maintenance Company Direct Support Maintenance Company Direct Support Supply Company Field Service Company Two Truck Companies Medical Company Direct Support Ammunition Company Chemical defense, signal, intelligence, and military police units of platoon size Four headquarters elements Air defense assets are integrated with the units for point defense. The Support Brigade has a personnel strength of 2,314 divided equally among those in the open, in tents, and in vans. There are seventy repair or shop vans in which personnel could be working. The deployment of the support brigade is assumed to be the same, whether offense or defense. Appendix F contains details on unit description and exposure estimates for icons in the Support Brigade. Note that casualty estimates are based on the assumption that all personnel are involved in extravehicular activities at the time of attack. Thus, collective protection that would be afforded by vehicles and tents was not considered in AMedP-8 Chemical. c. Light Infantry Brigade The Light Infantry Brigade, comprised of three infantry battalions, an artillery battalion, and a support battalion, is patterned to emulate an airborne or other light, rapidly deployable infantry brigade; its assigned mission is perimeter defense of an airfield. The brigade is deployed with the three battalions forming a 360-degree defense, as if protecting an aerial port of debarkation in preparation for the receipt of follow-on forces (see Figures G1 and G2). Each infantry battalion occupies a portion of the perimeter; a company reserve is maintained in each battalion area. The battalion logistical elements are consolidated with the brigade support battalion. This brigade has a strength of 3,454 personnel. Appendix G 17 contains details on unit description and agent exposure estimates for the Light Infantry Brigade. Although the unit descriptions in Appendix G indicate that foxholes are available for a fraction of the personnel, casualty estimates for the Light Infantry Brigade assume all personnel are unsheltered at the time of attack. Agent Data9 As shown in Figure III-1, agent characterization data is one of the inputs into VLSTRACK. AMedP-8 Chemical calculations used the default set of agent data provided with the VLSTRACK model to characterize chemical agents. VLSTRACK uses the following agent characteristics: bulk density, dissemination efficiency, median effective 2. dose, probit slope, freezing temperature, molecular weight, volatility coefficients, heat of vaporization, viscosity, surface tension, agent vapor diffusivity in air, and droplet spread factor. Table I-23 defines the chemical agent characteristics used by VLSTRACK, and Table I-24 presents the agent data. Delivery System and Munitions Data10 As with agent data, the calculations made for AMedP-8 Chemical used the default set of delivery system and munitions data provided with the VLSTRACK model (see Figure III1). The model uses the following delivery system and munitions characteristics: fill weight, height of burst, firing rate, number of delivery systems in attack, downrange and cross-range 3. target standard deviations, droplet mass-median diameter, droplet distribution sigma, line source length, line source fall angle, and cloud sigma. Table I-25 defines the delivery system and munitions characteristics used by VLSTRACK, and Table I-24 presents the data used to create AMedP-8 Chemical. 4. Meteorological Data As shown in Figure III-1, meteorological data is one of the inputs into VLSTRACK. Inputs include data for wind direction, wind speed, air temperature, degree of cloud cover, and the Pasquill stability category. Table I-27 defines the meteorology characteristics used by VLSTRACK, and Table I-28 presents the meteorology data used for each munitions/attack intensity combination. 9 Chemical agent data are captured in the VLSTRACK input file VLSAGN.PAR. Munitions data are captured in the VLSTRACK input file VLSMUN.PAR. 10 18 B. INTERMEDIATE CALCULATIONS As shown in Figure III-1, the AMedP-8 methodology uses the input data on tactical formation, agent characteristics, munitions characteristics, and meteorology in a series of intermediate calculations. These calculations generate an agent “cloud” and determine the aimpoints to generate that cloud, for use in subsequent calculations. 1. Chemical Agent Clouds The chemical agent clouds used in the AMedP-8 methodology are approximations of the downwind agent hazard resulting from a release of chemical agent, expressed in planar dimensions over time. As noted in Section II.B.5, the VLSTRACK model, version 1.6.1, was used to generate chemical agent clouds for AMedP-8.11 The model considers all the agent, munitions, and meteorology data described above. Release of chemical agents typically causes significant hazards from both vapor and liquid, and the transport and dispersion of each is significantly different. Thus, VLSTRACK generates separate clouds for vapor and liquid forms of agent. The model considers secondary evaporation of liquid on the ground in addition to the evaporation of the liquid in the cloud. The secondary evaporation is approximated in the vapor cloud. The cumulative doses received by personnel over time from both liquid and vapor hazards are considered in subsequent casualty calculations. During the development of AMedP-8 Chemical, both vapor and liquid clouds were created for each combination of agent, delivery system, and attack intensity. However, the GB liquid clouds were null in all cases and were not considered further in the development of casualty estimates. Agent concentration is reported as a two-dimensional grid for each of a series of time steps. For AMedP-8 Chemical, the grid has 201 points on each side, the maximum allowed by VLSTRACK. In addition, AMedP-8 agent clouds have self-adjusting grid sizes, meaning the grid size changes over time to encompass the hazard as it grows after release and then shrinks as it dissipates. 11 The VLSTRACK model is capable of providing three types of output: deposition, dosage, and vapor/droplet/particle concentration. Deposition output provides estimates in terms of mg/m2 on the ground. Dosage output provides estimates in terms of mg-min/m3. Concentration output is in terms of part/m3 of airborne droplets or particles and was not considered in developing AMedP-8. VLSTRACK can provide output in four dimensions—three spatial dimensions, and time. In the variant of VLSTRACK used to develop AMedP8, the vertical dimension was restricted to a single point, with output provided for x and y locations on a plane intersecting the vertical dimension. For deposition, this output was calculated at ground level, or a height of zero meters; for dosage output, this was calculated at an approximate breathing height of two meters. 19 As noted, the use of the BioStrike model requires agent cloud data reported in a specific format; to streamline the methodology, IDA developed a version of VLSTRACK, called Gridgen, to report the outputs of VLSTRACK in a BioStrike-compatible format. The Gridgen model also manages time steps slightly differently than VLSTRACK. VLSTRACK version 1.6.1 allows users to specify meteorological data for up to 24 time periods of uniform duration, which may be as short as one minute or as long as one hour. It will report up to 60 outputs per time period, but the minimum reporting interval is one minute. As with time periods, reporting intervals are of uniform duration. The GRIDGEN model, on the other hand, allows users to specify non-uniform time steps, using a scheme illustrated in Figure III2. NUMBER OF DATA TIME PERIODS 12 NUMBER OF TIME STEPS, BY DATA TIME PERIOD (1 THROUGH NVTIMP, RESPECTIVELY) 12 24 12 12 12 12 12 12 24 24 24 12 TIME SPACING BETWEEN TIME STEPS, BY DATA TIME PERIOD (MINUTES) 1.00 2.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 Figure III-2. Extract from GRIDGEN Special Inputs File Used For AMedP-8 Chemical In this case, Gridgen uses 12 data time periods. The first comprises 12 time steps of one-minute duration; the second, 24 time steps of two-minute duration; the third, 12 time steps of five-minute duration; and so on. The initial advantage of this scheme over the default approach used by VLSTRACK was that it allowed users to conserve computational time.12 Users could choose short, high-resolution, but computationally intense time steps at those points in the cloud evolution at which the chemical hazard is changing most rapidly— typically in the immediate aftermath of release—and switch to longer, lower-resolution time steps at other times where the hazard is changing more slowly. VLSTRACK v.1.6.1 and IDA’s GRIDGEN adaptation of the model accepts the use of time varying meteorology in increments of one hour. Although IDA’s GRIDGEN adaptation of the model allows for meteorological data to be input in user-defined increments as small as one minute, meteorological data used to develop the chemical volume were input on an hourly basis. 12 At the time the AMedP-8 Chemical was developed, computational speed was such that single VLSTRACK runs frequently took several hours to complete. At present, the same runs would take just a few minutes. 20 2. Aimpoint Determination The BioStrike model can be run in several modes, two of which were used extensively in the development of AMedP-8 Chemical. In Maximization mode, BioStrike will examine all possible attack points within a user-defined search area and output that point or set of points resulting in the largest number of expected casualties. This calculated aimpoint can then be used as an input to BioStrike’s Evaluation mode, which will output the total number of expected casualties and the amount of agent exposure at each troop location. In the development of AMedP-8 Chemical, the BioStrike Maximization mode was used to determine the optimal aimpoint for each combination of agent, munitions, and attack intensity against each tactical scenario. Separate aimpoint calculations were performed for the protection available and protection unavailable cases. When using BioStrike Maximization mode, the user must define a search area for which the model evaluates all possible aimpoints along an x,y grid, with user-defined distances between grid points. The search area can be any polygonal shape, and the model can be directed to search either within or outside the boundaries of any of the polygon’s sides. Because all the delivery systems considered in the chemical volume would typically be used in on-target attacks, the search area for the AMedP-8 aimpoint calculations was defined as the area contained within the outer physical boundaries of the tactical unit. In this case, the model was directed to evaluate aimpoints at 0.5 kilometer distances apart in both the x and y directions. The search boxes defined for each tactical scenario and the associated optimal aimpoints are shown in Figures III-3 through III-9 below. Note that for these figures, cross-wind and down-wind distances are in kilometers. 21 60 55 50 45 40 35 30 25 20 15 10 0 5 10 15 Troops Search Box 20 25 30 Attack Locations Figure III-3. Optimal Aimpoints: Heavy Brigade, Forward Maneuver, Movement to Contact 54 52 50 48 46 44 42 40 38 4 6 8 10 Troops Search Box 12 14 16 Attack Locations Figure III-4. Optimal Aimpoints: Heavy Brigade, Forward Maneuver, Offense 22 65 60 55 50 45 40 35 30 25 20 0 5 10 Troops 15 Search Box 20 25 Attack Locations Figure III-5. Optimal Aimpoints: Heavy Brigade, Forward Maneuver, Defense 60 50 40 30 20 10 0 0 5 10 15 Troops Search Box 20 25 30 Attack Locations Figure III-6. Optimal Aimpoints: Heavy Brigade, Brigade Support Area, Movement to Contact 23 21 20 19 18 17 16 15 14 13 12 11 11 12 13 14 Troops 15 Search Box 16 17 18 19 Attack Locations Figure III-7. Optimal Aimpoints: Heavy Brigade, Brigade Support Area, Offense and Defense 32 30 28 26 24 22 20 18 7 9 11 13 Troops 15 Search Box 17 19 Attack Locations Figure III-8. Optimal Aimpoints: Support Brigade 24 21 23 20 18 16 14 12 10 8 0 2 4 6 Troops Search Box 8 10 12 Attack Locations Figure III-9. Optimal Aimpoints: Light Infantry Brigade In determining optimal aimpoints in BioStrike, the model typically considers “optimal” to mean the greatest number of expected casualties. Expected casualties are calculated using a probit response methodology, where a given level of exposure is associated with a given probability of effect; the greater the exposure, the more likely it is to cause injury. Thus, BioStrike would output as “optimal” the aimpoint that would result in maximal total agent exposure across all troops in the scenario. For the AMedP-8 Chemical, however, aimpoints were calculated differently. The objective was not to maximize exposure, per se, but rather to maximize the load on the medical system. This meant that the modeling had to reflect a desire to maximize the number of individuals with exposures causing injurious but less-than-lethal effects. Simply maximizing total exposure could have resulted in proportionately large numbers of prompt fatalities who would never enter the medical system. To accomplish this, the first step was to determine the range of doses that would have the desired level of effect. The ranges selected were based on the injury severity categories established for each agent.13 For the nerve agents GB and VX, the values associated with 13 See Section IV.B.1 for a discussion of Injury Severity Categories. 25 injury categories 3 through 5 were chosen. For HD, with its combination of ocular, skin, and respiratory effects, the selection was more difficult. The range eventually chosen represented the low end of ocular effects on the one hand and the median lethal dose for respiratory effects on the other. Table III-4 provides the specific values used. Table III-4. Dose Ranges Used to Determine Optimal Aimpoints Agent Lower Bound Value 3 VX 0.4 mg HD 5 Severity Category mg-min/m3 GB Upper Bound mg-min/m3 Value 3 30 3 4 mg Ocular 2 Severity Category mg-min/m3 1000 5 5 mg-min/m3 Respiratory ~6/ LD50 Skin ~6 Note that in the table above, values for GB and HD are expressed as vapor dosage; for VX, they are expressed as liquid. BioStrike does not have the capability to evaluate the combined effects of vapor and liquid exposures in its Maximization mode. Therefore, for VX and HD releases, which typically have both a vapor and liquid component, the dominant component—the one with the greatest capability to generate injurious but less-than-lethal effect—was used to determine optimal aimpoints. For VX, this was liquid, while for HD, this was vapor. The modeled attacks with GB did not have a liquid component, so all exposures were calculated using vapor. The next step was to input these values into the BioStrike general data file. A dose response curve is generally represented in BioStrike as a series of exposure values with an associated probability of injury. The variables used are FILLAX, which defines exposure values, and FILLAY, which defines the injury probability associated with each value of FILLAX. A standard set of FILLAX and FILLAY values for GB, with an LD50 of 70 mgmin/m3 and a probit slope of 12 would be: ‘FILLAX( 3,.)’ 0. ‘FILLAY( 3,.,1)’ 0. 44.80 51.05 54.74 57.38 59.56 61.50 63.30 65.01 66.68 68.33 … .01 .05 .10 .15 .20 .25 .30 .35 .40 .45 … Figure III-10. Standard BioStrike Inputs for GB For any given calculated exposure, the probability of injury is calculated by interpolation. In the example above, an exposure of 70.00 mg-min/m3 has a 50% probability of lethality, while an exposure of 71.71 mg-min/m3 has a 55% probability of lethality. If 26 BioStrike estimates an exposure of 70.68 mg-min/m3, it would calculate an associated 52% probability of lethality. To determine optimal aimpoints for AMedP-8 Chemical, the FILLAX and FILLAY values were designed to exclude exposures outside the selected ranges, while treating all exposures within those ranges as equally valuable. The set used to optimize GB exposures was: ‘FILLAX(19,.)’ ‘FILLAY(19,.,3)’ 2.9999 3. 5.9999 6. 14.9999 15. 29.9999 30. 0. 1. 1. 1. 1. 1. 1. 0. Figure III-11. BioStrike Inputs for GB Used to Determine Optimal Aimpoints As shown, this set of values would ignore all exposures less than 3 mg-min/m3 and greater than 29.9999 mg-min/m3, while counting every exposure in between as an expected casualty. When BioStrike is run in Maximization mode, it returns the aimpoint that generates the greatest number of individuals with exposures within the defined range. This procedure was used to determine optimal aimpoints for both protection available and protection unavailable cases. Recall that for the protection available case, it is assumed that immediately following the attack, all personnel will don the mask within one minute and the full protective ensemble within nine minutes. To implement this in the BioStrike Maximization mode, model run time was truncated at appropriate points, given the agent and its dominant form of exposure. Since ocular and respiratory injuries are the dominant effects of vapor exposure, exposures were calculated for only the first one minute after attack in the GB and HD cases; after that point, masking would prevent further ocular or respiratory exposure. In the VX case, on the other hand, masking alone does not appreciably inhibit liquid skin exposures, so exposures were calculated for the first nine minutes after attack; thereafter, the full protective ensemble would prevent further skin exposure. In the protection unavailable case, on the other hand, the BioStrike model calculated exposures for the duration of the agent hazard. C. CALCULATION OF AGENT EXPOSURE 1. BioStrike Evaluation Mode The final step in calculating individual agent exposures involves running the BioStrike model in its Evaluation mode. In this mode, the model simply overlays agent clouds on tactical scenarios at optimal aimpoints and calculates the amount of agent exposure at all grid points occupied by individuals in the tactical scenarios. 27 Typically, the model would then use the set of exposure values (FILLAX) and associated probability of casualty values (FILLAY) to determine the expected number of casualties at each grid point given the level of exposure, and sum them to determine the total number of expected casualties resulting from the postulated attack. For AMedP-8 Chemical, however, BioStrike was used only to calculate exposure by grid point;14 the effects of that exposure on personnel were evaluated separately, as described in Section IV. Since BioStrike does not typically include zero-value exposures in its output, the model needed to be adjusted to obtain exposures for all grid points. By setting all probability of casualty (FILLAY) values equal to one—even those associated with an exposure value ( FILLAX) of zero—BioStrike then reported exposure for all occupied gridpoints in the scenario.15 Separate BioStrike runs were conducted for each combination of tactical scenario, agent, delivery system, attack intensity, and protection status. In addition, for HD and VX, separate runs were conducted for both vapor and liquid clouds. 2. BioStrike Output Format The BioStrike model output is reported in a flat text file. This output can take a variety of forms; for AMedP-8, it was set up to report grid point number, grid point x,y reference, fractional casualty rate, expected casualties, and exposure for all grid points in a given tactical scenario. Figure III-12 provides an example of the output generated for AMedP-8, in this case a portion of the results for a moderate-intensity GB artillery/MRLs attack against forward maneuver units of a heavy brigade on offense. In the sample output shown, the fractional casualty rate is equal to 1 because all values for FILLAY are equal to 1. The number of casualties, therefore, is equal to the number of individuals located at the associated grid point. Note that the titles “Fractional Casualties” and “Number of Casualties” can be misleading in this output format; since the status of all occupied grid positions is reported, even personnel with vapor exposures of 0.0000E+0 are listed as ‘Casualties’ (see Section IV.C for a discussion on casualty definition and calculation methods). Vapor exposures16 are given in mg-min/m3; liquid exposures are given in mg. 14 For AMedP-8 Chemical, grid point numbers correspond to icon numbers. These exposure values can be found in Appendices A-G. 16 Note that the “Agent Inhaled” values in the BioStrike output can be interpreted as inhaled agent exposure values or ambient exposure values, depending on the breathing rate assumed. To achieve ambient exposures, a breathing rate of 0 L/min was assumed in AMedP-8. 15 28 Line # 1 2 3 : : 34 35 36 37 38 39 Occupied Grid Position #: Xwind, Upwind 1: 11.465, 50.497 2: 11.564, 50.495 3: 8.693, 50.315 Fractional Casualties 1.000000 1.000000 1.000000 37: 40: 41: 43: 44: 48: 1.000000 1.000000 1.000000 1.000000 1.000000 1.000000 9.376, 45.557 10.792, 42.386 9.312, 45.638 10.740, 42.320 10.438, 42.496 10.165, 46.551 Number of Agent Casualties Inhaled 4.00 0.0000E+0 4.00 0.0000E+0 4.00 0.0000E+0 2.00 5.00 2.00 1.00 2.00 1.00 0.0000E+0 2.1987E+1 0.0000E+0 1.7648E+1 3.2972E+0 0.0000E+0 Figure III-12. Sample BioStrike Output 3. Post-processing of Protection Available Case Data To account for skin protection afforded by masking, calculation of exposures in the protection available cases required an additional step, involving post-processing of the data output by BioStrike. As discussed earlier, for the protection available case it was assumed that immediately following the attack, all personnel don masks within one minute and the full protective ensemble within nine minutes. This means that protected personnel would experience ocular and respiratory exposures for one minute and skin exposures for nine minutes. However, the mask will provide protection to those areas of skin it covers, so that skin exposure would be somewhat mitigated. The AMedP-8 calculations assume a typical skin surface area per individual of 1m2 and a typical head and neck surface area of 0.07m2. In the first minute after attack, skin exposures would be 100% of the exposure calculated by BioStrike. In minutes two through nine, however, skin exposure would be only 93% of that calculated. While it is possible to evaluate partial effects of protective measures within the BioStrike model, it is not possible to vary those effects over time. Therefore, consideration of the mitigating effects of masking on skin exposure had to be done as a post-processing step. For each protection available case, BioStrike was run twice in its Evaluation mode: once with exposure truncated at one minute and once with exposure truncated at nine minutes. In an Excel spreadsheet, the one minute exposure values were subtracted from the nine minute exposure values to obtain the exposure for minutes two through nine. This value was then multiplied by 0.93 to determine mitigating effects of masking on skin exposure. 29 Finally, the one minute exposure values were added back in to determine the total skin exposure, from time of attack through masking and donning of the full protective ensemble. 30 IV. CASUALTY ESTIMATION METHODOLOGY Section III described the methods IDA used to estimate vapor and liquid exposure using VLSTRACK, Gridgen, and BioStrike, and certain inputs from SAIC. IDA then provided these values to Pacific-Sierra Research (PSR), who calculated casualties and performance values and generated injury severity estimates for each scenario. Building on the Consolidated Human Response Nuclear Effects Model (CHRNEM) PSR had designed for the development of AMedP-8 Nuclear, and teamed with ARES Corporation, PSR applied a similar methodology to determine the effects of chemical exposure on performance; this model was called the DNA Improved Casualty Estimation Effort (DICE).17,18 The methodology prescribed by PSR did not account for separate liquid and vapor exposures; instead, the model utilized an equivalent vapor dose value. The equivalent dose was effectively the value of a single vapor dose which could be expected to produce the same injury severity signs and symptoms as those resulting from the combination of vapor and liquid doses received. The equivalent dose was used to determine the Injury Severity Category (ISC) for affected personnel, and was used in the DICE algorithm to determine performance degradation. For the nerve agents that produce a reaction in one system only – the nervous system – a single Injury Severity Category was determined based on the equivalent dose. For GB, the equivalent dose was solely a function of vapor dose and the resultant inhalation and percutaneous effects; due to the non-persistent nature of the agent, the liquid dose was considered negligible and neglected. For VX, the equivalent dose was a function of the liquid dose (percutaneous effects only) and vapor dose (both inhalation and percutaneous effects) as described in Section IV.A. The injury severity calculation for HD was slightly more complex since, for HD, the injury severity category is divided into symptoms as they impact three different systems – ocular (E), respiratory (R), and skin (S). Ocular and respiratory signs and symptoms were assumed to be a function of vapor dose only. Skin signs and symptoms, on the contrary, resulted from both vapor and liquid exposure, or from the equivalent dose. In addition to being used to determine the Injury Severity Categories for affected personnel, the equivalent dose for GB and VX and the vapor and equivalent doses for HD were used to calculate performance as described in Section V. 17 18 McClellan et al., 1998. p. 1. PSR manipulated the data as required to achieve a format compatible with their models. 31 A. CALCULATION OF EQUIVALENT DOSE As summarized above, the equivalent dose was a value computed by PSR for use in the DICE algorithm. The equivalent dose was calculated using a series of ratios comparing inhalation and percutaneous effects as a result of both the estimated vapor and liquid exposures generated in BioStrike. The equivalent dose is described here very generally and further detailed in Appendix J. For the nerve agent GB, equivalent dose was based solely on vapor exposure estimates; liquid exposure estimates were neglected in calculations. The equivalent dose, therefore, was a function of the inhalation and percutaneous effects of GB vapor. The percutaneous effects were scaled for use in the equivalent dose by using a ratio of the agent required to produce severe inhalation effects in 50% of the population (ICt50) to the agent required to produce severe percutaneous effects due to vapor in 50% of the population (ED50). Equivalent DoseGB = ƒ(GB Vaporinhalation, GB Vaporpercutaneous) For the nerve agent VX, both vapor and liquid estimated exposures contributed to the calculated equivalent dose. VX vapor contributed to both inhalation and percutaneous doses, while VX liquid contributed only a percutaneous dose. The equivalent dose for VX was a function of both VX vapor doses and the VX liquid dose. Ratios similar to that used in the GB equivalent dose calculation were used to correlate percutaneous effects due to liquid and vapor exposure to inhalation effects due to vapor. Equivalent DoseVX = ƒ(VX Vaporinhalation, VX Vaporpercutaneous, VX Liquidpercutaneous) Equivalent dose calculations for the blister agent HD were similar to those for VX in that vapor exposure resulted in both inhalation and percutaneous doses, while liquid exposure resulted in only a percutaneous dose. Ratios as described above were used in the calculation of HD equivalent dose. Equivalent DoseHD = ƒ(HD Vaporinhalation, HD Vaporpercutaneous, HD Liquidpercutaneous) Neither the chemical exposure estimates nor the equivalent doses have been presented in AMedP-8 Chemical. As part of the documentation effort, these estimates are tabulated in Appendices A through G; each Appendix pertains to one of seven scenarios, as discussed in Section III. For each scenario, the corresponding appendix contains a table listing insults by icon, for all cases (combinations of agent, munition, intensity, and posture). Copies of the original input files and the exposure data values generated by IDA during the preparation of AMedP-8 were used to produce the exposure tables included in 32 Appendices A-G. IDA regenerated these tables for inclusion in this documentation effort. The exposure data as included in Appendices A-G is similar to the data used to produce the original insult tables for AMedP-8; only minor calculation differences resulted. B. CORRELATION OF EXPOSURE TO INJURY SEVERITY CATEGORIES 1. Generating Injury Severity Category Tables Nerve agents GB and VX primarily impact a single type of tissue ― nerve tissue; the injury they produce in the body may therefore be considered systemic. It was assumed that effects were independent of the mode of exposure – inhalation or percutaneous – and the agent form – liquid or vapor. Blister agent HD, on the other hand, impacts multiple bodily tissues differently, including the eyes, the respiratory system, and the skin, producing different injuries at different times after exposure in each. In order to estimate the casualties resulting from chemical exposure, Injury Severity Categories were created. Easily recognized signs and symptoms of illness and their associated causative chemical exposure values were used to set the range boundaries for the Injury Severity Categories. Dose ranges resulting in ocular impairment, severe effects, and lethality in 10%, 50%, and 90% of the population were compared in order to select the Injury Severity Category ranges. These categories correspond to those used in the DICE model and are based on dose relationships adopted by the US Army Nuclear and Chemical Agency (USANCA)19. More information on the generation of these tables is provided in Appendix K. For GB, a single table was created indicating the chemical agent’s systemic effects solely due to vapor exposure. Dose symptomology tables did not exist for VX. Due to the similar toxicity mechanism of both nerve agents, GB and VX, the illness signs and symptoms were expected to be similar. To generate the injury severity category table for VX, an incidence dosage correlation was performed between GB and VX. Using the USANCA dose relationships at 10%, 50% and 90% severe inhalation effects incidence dosages, VX vapor inhalation exposures were correlated to GB vapor inhalation exposures. The same incidence dosages were used to correlate VX liquid percutaneous exposures to VX and GB vapor inhalation exposures. Using these correlations, the ranges for injury severity category due to VX exposure are directly relatable to the boundaries for injury severity due to GB exposure. A more detailed explanation of this methodology is contained in Appendix K. 19 McClellan et al., 1998. p. 4. 33 Due to HD’s different effects on several bodily tissue types, multiple injury severity categories were established to represent systemic/respiratory, skin, and ocular effects. The Injury Severity Category tables found below have been extracted pages 3-12 through 3-16 of the AMedP-8 Chemical manual. These tables were derived from tables shown in “Consequence Analytic Tools for NBC Operations” (McClellan, et. al.) and were changed by the working group to arrive at the tables shown below. It should be noted that the values listed under “Inhaled Vapor Exposure Range”, “Vapor Inhalation Exposure Range”, and “Exposure Range”, as listed in the following tables, represents the calculated Equivalent Dose. 34 Table IV-1. Injury Severity Categories from unprotected exposure to sarin (GB) vapor20 Injury Severity Category Injury Category Inhaled Vapor Exposure Range Ct (mg-min/m3) Typical Description Abbreviation 1 0 - .25 No obvious signs or symptoms of injury. No effects 2 .25 - 3 Nose drips fluid; airway secretions; variable ocular effects from miosis; headache; 10% have ocular or nasal response at 0.3 mg-min/m3; 50% at 0.5 mgmin/m3; and 90% at 0.7 mg-min/m3. Nose drip, miosis 3 3-6 Eye pain with frontal headache; blurred and dim vision; small pupils; some tightness in chest with increased airway secretions and occasional cough; most signs stop within hours but eyes signs may last up to one week.* Eye pain, headache 4 6 - 15 Severe headache; eye pain with sensitivity to light and blurred vision, maximal effects in all eyes exposed directly to GB vapor; closing airways with wheezing sounds; nausea/vomiting; weakness; most signs continue for 2 to 3 days but eye effects remain for several days.* Headache, nausea 5 15 - 30 Tight chest form closing airways and excessive secretions; coughing; vomiting; abdominal cramps; salivation; severe headache with anxiety and confusion; many have tremors or collapse, some convulse; 10% have severe effects at 23 mgmin/m3; some signs may continue for days or weeks.* Tight chest, tremors 6 30 - 50 Difficult breathing; weakness; urination; diarrhea; convulsions may be followed by collapse or respiratory failure; 50% have severe effects at 35 mg-min/m3; 10% die at 45 mg-min/m3.* Convulsions, some deaths 7 50 - 75 Collapse, paralysis or respiratory failure; 90% have severe effects at 55 mg-min/m3; 50% die at 70 mgmin/m3.* Respiratory failure, half die 8 >75 Respiratory failure or unconsciousness; 90% die at 110 mg-min/m3.* Unconsciousness, high mortality * Descriptions may include all signs and symptoms described for lower dosages. The typical description does not indicate the range of more or less severe responses that reflects normal individual variation. 20 AMedP-8 Chemical. p. 3-15. 35 Table IV-2. Injury Severity Categories from exposure to VX vapor or liquid21 Injury Severity Category Injury Liquid Vapor Category Deposition Inhalation Exposure Exposure Range Range (mg/m2) Ct(mg-min/m3) Typical Description Abbreviation 1 0 – 0.01 0 – 0.05 No obvious signs or symptoms of injury. No effects 2 0.01 – 0.4 0.05 – 2 Nose drips fluid; airway secretions; variable ocular effects from miosis; headache; 10% have mild ocular or nasal effects at 0.06 mg-min/m3, 50% at 0.09 mg-min/m3, and 90% at 0.14 mgmin/mg3. Nose drip, miosis 3 0.4 – 0.8 2–4 Eye pain with frontal headache; blurred and dim vision; small pupils; nausea; some tightness in chest with increased airway secretions and occasional cough; most signs stop within hours but eye signs may last up to one week* Eye pain, headache 4 0.8 – 2 4 – 10 Severe headache; eye pain with sensitivity to light and Headache, blurred vision, maximal effects in all eyes exposed directly nausea to GB vapor; closing airways with wheezing sounds; nausea/vomiting; weakness; most signs continue for 2 to 3 days but eye effects remain for several days.* 5 2–4 10 – 19 Tight chest form closing airways and excessive secretions; Tight chest, coughing; vomiting; abdominal cramps; salivation; severe tremors headache with anxiety and confusion; many have tremors or collapse, some convulse; 10% have severe effects from vapor inhalation at 17 mg-min/m3 or from percutaneous exposure to 15 mg-min/m3 of vapor or 2.8 mg of liquid.* 6 4–8 19 – 29 Difficult breathing; weakness; urination; diarrhea; severe Convulsions, tremors or convulsions may be followed by collapse or some deaths respiratory failure; 50% have severe effects from vapor at 25 mg-min/m3 or from percutaneous exposure to 20 mgmin/m3 of vapor or 5 mg of liquid; 10% die from vapor inhalation at 20 mg-min/m3 or from percutaneous exposure to 90 mg-min/m3 of vapor or 6 mg of liquid.* 7 8 – 12 29 – 40 Collapse, paralysis or respiratory failure; 90% have severe Respiratory failure, half effects from vapor inhalation at 37 mg-min/m3 or from 3 percutaneous exposure to 41 mg-min/m of vapor or 9 mg die of liquid; 50% die from vapor inhalation of 30 mg-min/m3 or from percutaneous exposure to 150 mg-min/m3 of vapor or 10 mg of liquid.* 8 > 12 > 40 Respiratory failure or unconsciousness; 90% mortality from Unconsciousness, high vapor inhalation at 45 mg-min/m3 or from percutaneous 3 mortality exposure to 250 mg-min/m of vapor of 16 mg of liquid.* * Descriptions may include all signs and symptoms described for lower dosages. The typical description does not indicate the range of more or less severe responses that reflects normal individual variation. 21 Ibid.. p. 3-16. 36 Table IV-3. Injury Severity Categories of eye effects from exposure to HD vapor22 Injury Severity Category Injury Category Exposure Range Ct (mg-min/m3) 1 0–5 No obvious signs or symptoms of injury. No effects 2 5 – 50 Reddened conjunctiva and tears that may blur vision; 10% have mild ocular effects at 6 mg-min/ m3; 50% at 25 mg-min/m3. Blurred vision 3 50 – 70 Eyes feel gritty and sensitive to light; many tears and swollen membranes reduce vision; recovery takes 1 to 2 weeks.* Light Sensitive 4 70 – 100 Eye discomfort; photophobia; non-stop tears flood eyes; 90% have mild ocular effects at 95 mg-min/m3; recovery takes 2 to 5 weeks.* Non-stop tears 5 100 – 150 Eyelids are swollen and eyes burn; eyes are too painful to keep open; damage to cornea; temporary relapses occur and convalescence may take 2 to 3 months.* Little vision 6 > 150 Eyelids are swollen shut and burning; eyes are too painful to open; convalescence from severe conjunctival and corneal damage may take several months after exposures to high dosages of HD.* Can’t see Description Abbreviation * Descriptions may include all signs and symptoms described for lower dosages. The typical description does not indicate the range of more or less severe responses that reflects normal individual variation. 22 Ibid.. p. 3-12. 37 Table IV-4. Injury Severity Categories of respiratory/systemic effects from exposure to HD vapor23 Injury Severity Category Injury Category Exposure Range Ct (mg-min/m3) Description Abbreviation 1 0 – 50 No obvious signs or symptoms of injury. No effects 2 50 – 70 Nauseated, swallows often.* Nausea 3 70 – 100 Dry mouth; dry cough; sneezing; runny nose; headache; nausea; may vomit once or twice; 10% have severe effects at 80 mg-min/m3; recovery may take 2 weeks.* Cough, headache 4 100 – 150 Sore throat; continuous cough; hoarseness; vomits; chest feels tight; headache; fever; 50% have severe effects at 135 mg-min/m3.* Coughing and vomiting 5 150 – 250 Hurts to breath; hacking cough; cannot speak; headache; dry vomiting; fatigued from vomiting and abdominal pain; 90% have severe effects at 230 mg-min/m3; bronchopneumonia may occur after 48 hours and recovery may take 1 to 2 months.* Voice loss, dry vomiting 6 250 – 1200 Severe chest pain; wheezing and shortness of breath; coughs up red colored mucous; 10% die at 600 mg-min/m3 and 50% mortality at 1000 mg-min/m3; deaths within a few days occur after choking with pulmonary edema, obstruction or pneumonia.* Choking, ± 50% die 7 >1200 Very severe effects; 90% mortality at 1700 mg-min/m3; pieces of dead tissue obstruct airways and add early deaths to those from edema or infection.* Obstruction, high mortality * Descriptions may include all signs and symptoms described for lower dosages. The typical description does not indicate the range of more or less severe responses that reflects normal individual variation. 23 Ibid.. p. 3-13. 38 Table IV-5. Injury Severity Categories of wet skin effects from exposure to HD vapor or liquid 24 Injury Severity Category Injury Category Vapor Exposure Range Ct (mg-min/m3) 1 0 – 25 2 Description Abbreviation No obvious signs or symptoms of injury. No effects 25 – 100 Skin sensitive to touch in tender areas (crotch, armpits, inside of elbow and knee); threshold effects in 10% at 30 mg-min/m3, in 50% at 50 mg-min/m3, and in 90% at 80 mg-min/m3.* Sensitive 3 100 – 250 Skin sore or itching and burning in tender areas; painful when moving; red body skin; tiny blisters on hands and neck.* Sore, red 4 250 – 500 Skin raw and painful or itching in tender areas; red, swollen body skin; large blisters on neck, fingers, and backs of hands; new blisters may appear each day for a week or more.* Blisters, swelling 5 500 – 750 Skin peels off leaving open raw areas and painful ulcers in tender areas; may vomit; raw areas may take several weeks to heal.* Raw ulcers 6 750 – 1500 Headache; nausea; fever or hypothermia; 10% have severe body skin effects at 1200 mg-min/m3 or at 350 mg liquid exposure over whole body; skin healing may take several weeks or months.*,** Systemic effects 7 1500 – 4000 50% have red, raw body skin at 2000 mg-min/m3 or 1400 mg liquid exposure over whole body; 90% have severe body skin effects at 3300 mg-min/m3 or 5500 mg liquid exposure over whole body. *,** Raw skin on body 8 4000 – 12,000 10% die at 6500 mg-min/m3 or 2700 mg liquid exposure over whole body; 50% die at 10,000 mg-min/m3 or 7000 mg liquid exposure of whole body. *,** Intoxication, ± 50% die 9 >12,000 90% die at 15,000 mg-min/m3 or 18,000 mg liquid exposure over whole body. *,** Shock, high mortality * Descriptions may include all signs and symptoms described for lower dosages. The typical description does not indicate the range of more or less severe responses that reflects normal individual variation. ** 2. Determining Injury Severity Category As stated above, in the case of GB, only vapor dose was considered; little liquid exposure or percutaneous dose was expected due to the nature of the agent. In order to determine the Injury Severity Category as a result of exposure to GB, the equivalent dose (as 24 Ibid.. p. 3-14. 39 a composite of inhalation and percutaneous doses resulting from vapor exposure) is entered into the table. The expected symptoms and ISC can then be determined. For VX, similarly, the equivalent dose is used to determine ISCs. It is important to note that Table IV-2 data were not used in determining VX ISCs during the generation of AMED P-8 Chemical. Table IV-2 did not exist when PSR began building their DICE methodology; the derivation of this table is shown in Appendix K. To calculate the ISCs for VX, using a correlation ratio comparing the amount of GB vapor required to produce severe inhalation effects in 50% of the population to the amount of VX required to produce severe effects (both inhalation and percutaneous) in 50% of the population, VX liquid and vapor doses were converted to an equivalent GB dose and then entered into Table IV-1 (ISCs from exposure to GB vapor or liquid) in order to determine the ISC. Table IV-6. VX Injury Severity Category Calculation Comparison Percutaneous Equivalent Exposure (mg-min/m3) Total Equivalent Exposure (mg-min/m3) Injury Severity Category Total Equivalent Exposure (mg-min/m3) Percutaneous Equivalent Exposure (mg-min/m3) Inhalation Equivalent Exposure (mg-min/m3) Liquid Exposure (mg) 24 rounds at aimpoint (17.65, 20.15) 7.11E+01 5.67E+00 1.83E+02 1.89E+02 8.67E+01 6.38E+00 2.23E+02 2.30E+02 1.27E+00 1.54E+00 4.72E+00 6.26E+00 1.15E+00 1.44E+00 4.32E+00 5.76E+00 1.08E+00 2.26E-01 2.93E+00 3.15E+00 7.45E+00 2.30E+00 2.09E+01 2.32E+01 5.62E+00 1.72E+00 1.58E+01 1.75E+01 Inhalation Equivalent Exposure (mg-min/m3) 5.67E+00 6.38E+00 1.54E+00 1.44E+00 2.26E-01 2.30E+00 1.72E+00 Using GB Tables Injury Severity Category Case 1: Unprotected 38 2 40 2 778 1 780 3 993 3 994 8 996 7 Vapor Exposure (mgmin/m3) Number of Persons Grid Position (Icon #) VX 250kg Bomb Heavy Attack Height of Release: 70m Using VX Tables 8 8 4 4 3 6 5 7.94E+00 8.93E+00 2.16E+00 2.02E+00 3.16E-01 3.22E+00 2.41E+00 5.06E+02 6.16E+02 1.10E+01 1.01E+01 7.88E+00 5.54E+01 4.17E+01 5.14E+02 6.25E+02 1.32E+01 1.21E+01 8.19E+00 5.86E+01 4.42E+01 8 8 4 4 4 7 6 Due to VX’s steeper probit slope, using the GB ISC tables vice the VX ISC tables, results in assignment of higher ISCs than would have been assigned had the VX tables been used. At the extremes and at the midpoint, the table results are similar. Had Table IV-2 been used, vice Table IV-1, a similar number of casualties would have resulted, however the ISCs of the casualties would have been lower for many of the casualties. For HD, the process is slightly more complex. The ISC for HD is a composite of the ocular (E – eye), respiratory (R), and skin (S) categories, which is tabulated for exposures in AMedP-8 Chemical aand written as 1-2-3, for example, where the ocular ISC is 1, the respiratory ISC is 2, and the skin ISC is 3. Equivalent dose is used to determine the skin ISC. Because ocular and respiratory effects result only from vapor exposure, only the vapor exposure is used to determine the E and R ISCs. 40 It is important to note that the documentation process revealed the following errata: although Injury Severity Category six is the highest category given for eye effects due to HD exposure, category five is the highest category assigned in the tables given in Appendices 410 of AMedP-8 Chemical. Calculations to produce Appendices A-F for this documentation effort indicate that approximately fifty attacks resulted in an ISC six; in AMedP-8 Chemical, these attacks are included, however, they are listed with an ISC of five vice ISC six. IDA found this error; we are assuming that, because performance is based on exposures vice ISC, this error will not impact the performance calculations. Dose (mg) can be determined using the above tables. For inhalation effects, as shown in Tables IV-1, IV-2, and IV-4, the assumed breathing rate of 15 l/min (.015 m3/min) was used. Percutaneous doses, based on the assumption of 1 m2 exposed skin/person, were converted to equivalent vapor doses and added to the inhaled vapor doses to calculate effective dose. The resulting effective dose is equivalent to the inhaled vapor exposure (labeled “Inhaled Vapor Exposure Range”) given in the Injury Severity tables (Tables IV-1 through IV-5). 41 V. CALCULATION OF POST-ATTACK PERFORMANCE CAPABILITY In addition to using the calculated exposures for determining ISC, as described in Section IV, exposures were input into the DICE model to determine performance capability of personnel following exposure to chemical agent. The vapor and liquid doses calculated by BioStrike were used as the basis for these performance calculations. Vapor, liquid, and effective doses were calculated (as described above); in addition, VX doses were converted to equivalent GB doses for calculation. Sign/symptom severity profiles were generated for each agent as a function of equivalent dose, time, and physiological system affected. A scale of one to five (one is the best or least injurious, five is the worst) delineates the sign/symptom severity categories. For each dose range, the severity category is plotted against time on a logarithmic scale. A table is produced for each system affected. There are six systems affected by nerve agents GB and VX―upper gastrointestinal, lower gastrointestinal, muscular, ocular, respiratory, and mental―and four impacted by HD―skin, system, respiratory, and ocular. A. DETERMINING SIGN/SYMPTOM SEVERITY PROFILES In order to determine the sign/symptom severity profiles, crewmembers loading and firing an M119A1 light Howitzer were selected as representative of a combat soldier. Their performance can be measured as a function of time, accuracy, or a combination of both. For the DNA/IDP model, it was determined that only subject matter experts (SMEs) could provide accurate estimates of the impact of injury on time to perform tasks. The signs and symptoms associated with each chemical agent and exposure range were explained as textual descriptions. SMEs―enlisted personnel with experience operating a Howitzer and performing other general tasks―were given questionnaires with the associated signs/symptoms descriptions and asked to quantify how long particular tasks would take given the signs/symptoms prescribed. These values were then quantified to establish performance characterizations, using the Defense Nuclear Agency/Intermediate Dose Program (DNA/IDP) methodology. 25 Given the chemical insults, the DICE algorithm estimates performance ― the capability of individuals performing general combat tasks at various times after exposure. It is important to note that injury severity categories and sign/symptom severity categories are not the same; ISCs prescribe the manifest symptoms resulting in the primary 25 Anno, G. G., et al., Predicted Performance on Infantry and Artillery Personnel Following Acute Radiation or Chemical Agent Exposure, Defense Nuclear Agency, Washington DC, DNA-TR-93-174, November 1994. 42 system(s) affected based on particular dose ranges, whereas sign/symptom severity categories describe the changing symptoms in several different physiological systems over time. Table V.1 provides one example: given HD vapor and liquid exposure from a light artillery attack, the overall ISC and the sign/symptom severity categories at three hours and thirty days, with calculated performance, are shown. Table V-1. HD Exposure, ISC, and Performance Calculations B. 3.89E+01 1.90E+02 7.92E+02 5.84E+01 6.53E+01 3.47E+02 1.45E+03 1.11E+02 Injury Severity Category Equivalent Exposure (mg-min/m3) Case 1: Unprotected 361 8 9.72E+00 363 8 7.60E+01 365 8 3.16E+02 382 8 2.80E+01 Liquid Exposure (mg) Vapor Exposure (mg-min/m3) Number of Persons Grid Position (Icon #) Mustard (HD) 152mm Artillery Light Attack Height of Release: 15m 3 Hours -30 Days -Sign/symptom Severity Categories Sign/symptom Severity Categories E R S Skin Resp Sys Oc Perf Skin Resp Sys Oc Perf 18 rounds at aimpoint (10.55, 43.65) 2 1 2 1 1 1 1 1 1 1 1 1 1 4 3 4 2 1 1 2 0.6420 1 1 1 1 1 6 6 6 5 3 1 3 0.0021 1 2 3 1 0.7055 2 1 3 1 1 1 1 1 1 1 1 1 1 PHYSICAL EFFECTIVENESS AS A FUNCTION OF PERFORMANCE The performance measure helps determine the post-exposure physical effectiveness of an individual after exposure. Physical effectiveness is decremented as in the combined injury model26 using a measure, which accounts for the increased time required to perform a task correctly. Thus, an individual who is described as 50% capable requires twice as much time to perform a task as required by someone who is 100% capable. Estimates of residual performance (performance capability of a typical soldier who was initially healthy) were based on the earlier mentioned questionnaire-based study, which considered the typical symptoms and severity that would be caused by exposure to a chemical agent. Table IV-6 defines the categories used in the tables described in Sections 3.0-3.3 of the AMedP-8 Chemical manual, and listed below. Personnel categories such as “fatalities,” “casualties,” and “capable” found in the tables are based on individual physical effectiveness as determined by the DICE model. The use of 25% capable as the defining level of a casualty does not restrict an individual from entering the medical system at any other level of performance; however, the expectation is that the exposure levels reducing performance to 25% would result in symptoms that would require medical treatment. Further, the concepts of physical effectiveness and percentage capabilities include those who are apparently fit for duty but have been exposed to chemical agent. Casualty flags are assigned for any individual whose 26 McClellan et al., 1998. p. 17. 43 performance drops to 25% or below at any time during the evaluation period. Performance for GB and VX was calculated at hours one and twelve and for the first seven days after exposure; performance for HD was calculated three hours after exposure, every day for the first week after exposure, and at days fifteen and thirty. In the PSR documentation, casualty flags for the HD injury categories were included27. IDA verified these values as the basis of our own performance calculations. It appears that, for a skin exposure of 500 mg-min/m3, an average of the sign/symptom severity – 2 – for the 250-500 mg-min/m3 range and the sign symptom severity – 5 – for the 500-1000 mg-min/m3 was used; only by using a skin sign/symptom severity of 3.5 at 500 mg-min/m3 was IDA able to reproduce the performance values included on the casualty flag tables. An individual whose performance has dropped to 25% capable or lower becomes a casualty. Over the course of the evaluation period – 3 hours to 30 days for HD and 1 hour to 7 days for GB and VX, the individual can remain a casualty, can become a fatality, or can eventually return to duty (RTD). The individual becomes a fatality if the calculated performance capability drops below the fatality performance threshold 0.01% for GB and VX or below 0.0023% for HD as shown in Table V.2. Table V-2. Performance Capability Categories. Category Definition Fatality <0.01% capable (GB, VX) <0.0023% capable (HD) Casualty >0% but <=25% capable (in medical system until recovery is >=75%) Capable >25% capable Return-to-duty (RTD) A casualty who recovers to >=75% capable Sick Again A return to duty (RTD) whose capability has dropped to <= 25% The PSR documentation indicates that the basis for selecting 0.0023% for HD was that it was higher than the lowest sign/symptom severity combination which resulted in a performance of 0.0022%28. IDA’s recalculation of performance for HD showed that the lowest demonstrated sign/symptom severity combination – 5-4-5-5 (skin-respiratory-systemicocular) – results in performance of .0013%; the next lowest combination was – 5-4-4-5 – with performance of 0.0024%. We are assuming that the fatality threshold was selected to be 27 28 Ibid. p. 65 – 69. Ibid. p. 36. 44 right below the second lowest sign/symptom severity category vice just above the minimum sign/symptom severity category as documented by PSR. If the individual’s calculated performance improves, the individual can eventually become an RTD once calculated performance increases greater than or equal to 75% capable. RTDs provide an estimate for expected recoveries, however, it is important to know that this value is only an estimate and should be used only as a worst-case basis for manning estimation. Performance calculations are based solely on illness progression as a result of chemical exposure; there is no accounting for medical treatment as part of the calculations in AMedP-8. The purpose of AMedP-8 was to estimate casualties for planning purposes. The individual, therefore, who becomes an RTD does so as the signs and symptoms of injury run their natural course; with treatment, this patient and others may potentially return to duty sooner. It should be noted29 that the performance criteria established by the DICE algorithms tend to overestimate fatalities as a result of vapor exposure and underestimate fatalities for liquid exposure. The impact of these inaccuracies, however, is not as obvious, because the targeting was optimized to maximize production of non-lethal casualties vice production of fatalities. C. GENERATION OF PERFORMANCE TABLES In AMedP-8, performance capability data are captured in three different types of tables for each scenario and each agent: Status of Unit Personnel Over Time Casualties Occurring by Time Period Personnel by Injury Category Personnel status after a chemical detonation is presented in the tables in Sections 4-10 of the AMedP-8 Chemical manual. There are two important notes about the generation of the above tables for HD. First, in order to avoid calculating and listing the effects of extremely low level exposures, soldiers 99.5% capable and above are considered 100% capable.30 Second, determining the time-dependent injury by casualty type, the associated category (eye, respiratory, skin) is assumed to have a resulting injury if the sign/symptom 29 30 Ibid. p. 37. Ibid. p. 54. 45 category31 level is greater than or equal to two (at the time of the evaluation), not if the injury severity category is greater than or equal to two, as might be assumed. So, an eye injury would be present if the sign/symptom severity ocular was greater than or equal to two. Similarly, a skin injury would be present with a sign/symptom severity skin greater than or equal to two. For respiratory, an injury is present when either the sign/symptom severity respiratory or systemic is greater than or equal to two. IDA recalculated the performance tables for HD exposure associated with the Heavy Brigade, Forward Maneuver, Movement to Contact and Heavy Brigade, Brigade Support, Movement to Contact (Appendices 4 and 5 in AMedP-8 Chemical). We’ve identified minor discrepancies in the data between what was published in AMedP-8 and what IDA recalculated. Although the number of total casualties are similar in most cases, the types of casualties, times at which they occur, and the resultant number of fatalities differ. IDA has not yet recalculated the GB or VX performance values. We utilized the methodology and values described above and in Annex L, however, we do not, as yet, have the course of sign/symptom severities over time and, without that, cannot yet verify the GB and VX tables. This requires additional resolution and is being worked on. 31 See Tables L.2 and L.3; these tables demonstrate the sign/symptom severity categories over time for each exposure range. 46 VI. REMAINING METHODOLOGICAL QUESTIONS During the course of the documentation efforts, IDA identified several inconsistencies and/or areas of inadequate documentation with the study methods. Several of these have already been identified above; additional questions are included below. These questions are being addressed as additional information is provided. A. EXPOSURE RANGE SELECTION A question was raised regarding the rationale used to select the DICE vapor exposure ranges which were used as the basis for the sign/symptom severity graph. In the DSWA technical report, page 39, the seven initial vapor exposure ranges are: 10-50, 50-70, 70-100, 100-150, 150-250, 250-500, and 500-1000 (all in mg-min/m3). These ranges, however, do not seem consistent with the injury severity category ranges. For example, for a skin exposure below 25 mg-min/m3, there is no injury, vice for exposures between 25 mg-min/m3 and 100 mg-min/m3, skin is sensitive and tender. Therefore, we were concerned that there is a risk that dividing the range at 50 mg-min/m3 vice 25 mg-min/m3 will miss capturing some symptomatic individuals. B. TABLE GENERATION During our attempt to replicate some of the tables found in AMedP-8 Volume III (Chemical), the following questions arose. The documentation defines casualties and fatalities; however, it does not explain if all, some or no fatalities are assumed to be casualties prior to becoming fatalities. We know from the documentation that the definition of a casualty is less than or equal to 25% performance and the definition of a fatality is less than or equal to 0.0023%. We were unable to determine if the definition of casualty is lower bounded by the definition of fatality. Our calculations using these values and the same starting exposures do not yield the same number of fatalities or casualties as the tables included in the appendices of AMedP-8 Chemical. In addition, an individual who becomes a fatality, under normal circumstances, can be assumed to have some type of medical treatment prior to become a fatality. Therefore, for estimation and planning purposes it would seem that casualties should include fatalities during that time period. Those numbers do not currently seem to be included as casualties. In addition, with regards to definitions, we were unsure of the connection, if any, between performance bands and RTD. When an individual was a casualty (below 25% performance) and improved to >25% performance but not above 75% (return-to-duty 47 criterion), it was unclear if he/she were counted in the capable by performance band and the casualty band, either or neither. In the Status of Unit Personnel over Time tables, it was unclear if the performance band, casualty and fatality values are cumulative. For example, in Table 7-56 of AMedP-8 Chemical, Status of Unit Personnel by Time Period, Heavy Brigade, Forward Maneuver, Defense, Bombs, Light Attack, at hour 3, 18 people have ERS casualties, with an additional 28 people below 100%. At the end of Day 1, 15 people have ERS casualties and 10 have ES casualties, 14 become fatalities and 13 additional are below 100%. We were unsure if 15 ERS casualties were new casualties or if they were 15 people who remained casualties from the previous day, with an additional three personnel having become fatalities. In the Casualties Occurring by Time Period tables, there was a question about how casualties and fatalities were determined. We did not know how to determine if fatalities were casualties from a previous day or if they became casualties and fatalities within a single time period. For example, in Table 7-62, Casualties Occurring by Time Period, Heavy Brigade, Forward Maneuver, Defense, MRLS/Artillery, Light Attack, after 3 hours, 30 people are ERS casualties. After one day, 15 people are fatalities and there are no casualties. This would seem to imply that 15 of the 30 became fatalities and 15 remain casualties. After 30 days, 21 people return to duty. This should not be possible, because if 15 became fatalities, then there should be only 15 available for return-to-duty. Otherwise, the assumption must be made that the fatalities are in addition to the 30 casualties, or that only some undefined portion of those 30 became fatalities. This may not be a good assumption because it leads to the indication that fatalities receive no medical treatment before becoming fatalities. In addition, a second type of discrepancy appears on several tables, including Table 7-66, Casualties Occurring by Time Period, Heavy Brigade, Forward Maneuver, Defense, Bombs, Light Attack. At hour 3, there are 18 casualties. At day one, there are 10 ES casualties and 14 fatalities, however, only 7 casualties listed in the total casualties section. Similarly in Table 7-66, Casualties Occurring by Time Period, Heavy Brigade, Forward Maneuver, Defense, Bombs, Moderate Attack. After 3 hours, 60 people are ERS casualties. After one day, 10 people are noted as ES casualties and 43 are listed as fatalities, however, in the total casualties section for day one, there are no total casualties. The way that we understand the tables, the total number of casualties by injury type should equal the number of casualties in the total injury section, however, we were unable to determine why this was not the case. 48 VII. AMedP-8 CHEMICAL DOCUMENT APPEARANCE The AMedP-8 Chemical manual is organized into eleven sections: Section 1. Section 2. Section 3. Section 4. Section 5. Section 6. Section 7. Section 8. Section 9. Section 10. Section 11. Introduction Methodology Casualty Tables- Explanation and How to Use Them Heavy Brigade, Forward Maneuver, Movement to Contact Heavy Brigade, Brigade Support Area, Movement to Contact Heavy Brigade, Forward Maneuver, Offense Heavy Brigade, Forward Maneuver, Defense Heavy Brigade, Brigade Support Area, Offense and Defense Support Brigade Light Infantry Brigade - Defense How To Find Casualty Estimates For Sample Problems Sections 1-3 provide the background and administrative information necessary to use AMedP-8. Section 11 provides a step-by-step set of instructions on how to use the document. Sections 4-10 are each specific to one of the seven tactical scenarios and are essentially identical in construction, including the tables that provide the data necessary for casualty estimation. Each section is divided into three subsections: one each for the chemical agents GB, VX, and HD. Within each subsection, the casualty estimation information is provided in two forms: casualties as a function of time, and casualties by type and intensity of injury. In each subsection, the first four tables are summary tables. They present estimates for each of the weapon/delivery system combinations for each of three attack intensities and for both protection available and protection unavailable postures. These four tables provide casualty estimates at 1 and 12 hours and 1 and 7 days after agent release. They also provide the information on the Status of Unit Personnel for the three delivery systems, three attack intensities, and two postures for the major time periods included in this manual. For example, Table n-1 (where n is the section number [4-10] in AMedP-8) presents the status of unit personnel at one hour after low, moderate, and high intensity GB attacks using Multiple Rocket Launch Systems (MRLS)/artillery, bombs, or Tactical Ballistic Missiles (TBMs) for both protective postures. The first four tables in each subsection allow the planner to rapidly compare medical workloads for units with or without protection available, across attack intensities. These estimates provide the total number of personnel in each category at the specified time. 49 Two sets of nine tables follow the initial Summary Tables in each subsection. The first set of nine provides the “Status of Unit Personnel Over Time” for the nine combinations of agent delivery system and attack intensity. The tables entitled “Status of Unit Personnel Over Time” are designed to provide an overview of the unit status at a specified time. Time is particularly important because a person’s effectiveness will change over time due to the progress of different injuries. For GB and VX, the total number of personnel in the unit who are casualties, fatalities, capable (cumulative and divided by performance bands), and Returned to Duty (RTD) are enumerated for the first hour, hour 12, and daily from day one to day seven. For HD, unit personnel in these categories are enumerated for hour 3, daily from day one to seven, day 15, and day 30. Estimates for light MRLS/artillery attacks are presented for personnel with protection unavailable and protection available, followed by tables of casualty estimates for moderate and heavy attacks. Attacks with bombs and TBMs follow similarly. The tables entitled “Casualties Occurring Over Time” provide estimates of the additions to each category—Casualties, Fatalities, RTD—as they occur for each time period. The last set of tables in each subsection is a pair of tables, entitled “Personnel by Insult Category” for protection unavailable and protection available postures, respectively. These tables provide an alternative method for categorizing personnel after a chemical agent exposure, i.e., by injury and/or by exposure level. This type of table provides estimates of personnel exposed to a range of insult levels and the resultant injuries. The tables are keyed to injury levels. An injury level is presented for each of the systemic effects of GB and VX, and for eye, skin, and respiratory/systemic effect of HD. More detailed information on the content and organization of AMedP-8 is available in Section 3 of the STANAG. 50 VIII. SUMMARY OF CASUALTIES BY SCENARIO AMedP-8 Chemical provides estimates of the numbers, types, and times of casualties resulting from the release of one of three different types of chemical agents (GB, VX or HD) by three different weapon delivery systems (MRLS/artillery, bombs, or TBMs) at three different attack intensities (light, moderate, or heavy) within seven different tactical targets. This analysis provides an overview of how those casualty estimates were derived and the limitations of the scenarios presented in AMedP-8. Tables VIII-1 through VIII-3, below, summarize the results of this analysis. 51 Sarin (GB) Casualties, TBMs (Heavy) Sarin (GB) Casualties, TBMs (Moderate) Sarin (GB) Casualties, TBMs (Light) Sarin (GB) Casualties, Bombs (Heavy) Sarin (GB) Casualties, Bombs (Moderate) Sarin (GB) Casualties, Bombs (Light) Sarin (GB) Casualties, Artillery/MRLS (Heavy) Sarin (GB) Casualties, Artillery/MRLS (Moderate) Sarin (GB) Casualties, Artillery/MRLS (Light) SubOperational Operational Area Area Table VIII-1. Summary of Casualty Scenarios, GB Heavy Brigade, Heavy Brigade, Heavy Brigade, Heavy Brigade, Brigade Heavy Brigade, Brigade Support Brigade Light Infantry Brigade Manuever Batallions, Manuever Batallions, Manuever Batallions, Support Area, Support Area, Offense Movement to Contact Offense Defense Movement to Contact or Defense 40 16 21 40 N/A 10 6 Length (Km) 20 24 45 20 N/A 7 6 Breadth (Km) 4,042 4,042 4,042 4,042 4,042 2,314 3,454 Population Maneuver Batallion Maneuver Batallion Maneuver Batallion Support Batallion Support Batallion N/A N/A Unit 10 10 15 10 6 Length (Km) 20 8 15 20 5 Breadth (Km) 1,047 1,047 1,047 1,013 1,013 Population Protection Protection Protection Protection Protection Protection Protection Protection Protection Protection Protection Protection Protection Protection Unavailable Available Unavailable Available Unavailable Available Unavailable Available Unavailable Available Unavailable Available Unavailable Available Immediate 0 0 0 3 10 9 0 0 2 1 55 5 52 0 Fatalities Casualty, 27 24 36 24 55 36 71 44 92 62 75 30 148 50 Surviving Casualty, Subsequent 0 0 0 0 3 3 0 5 5 0 0 0 8 0 Fatality Immediate 0 70 4 23 4 27 30 48 45 19 40 90 338 140 Fatalities Casualty, 85 13 123 49 105 44 171 38 232 86 300 100 588 144 Surviving Casualty, Subsequent 0 2 0 3 0 0 0 14 2 4 15 15 56 20 Fatality Immediate 42 13 74 4 0 53 96 23 46 80 63 155 200 276 Fatalities Casualty, 194 59 148 52 135 60 247 123 257 123 406 80 941 229 Surviving Casualty, Subsequent 6 0 0 3 4 3 4 7 19 1 25 0 40 27 Fatality Immediate 0 0 4 0 0 0 0 0 8 0 0 0 96 0 Fatalities Casualty, 79 21 101 11 93 18 154 33 180 40 270 10 486 10 Surviving Casualty, Subsequent 0 0 0 0 0 0 0 0 3 0 0 0 10 0 Fatality Immediate 0 18 44 0 0 11 74 25 4 57 0 35 50 17 Fatalities Casualty, 156 69 142 44 126 32 193 123 321 102 367 60 1030 81 Surviving Casualty, Subsequent 0 0 0 0 0 4 0 0 8 1 0 10 0 0 Fatality Immediate 82 18 31 0 0 34 78 4 45 17 85 60 50 86 Fatalities Casualty, 206 69 193 53 128 30 207 70 417 62 390 55 1147 138 Surviving Casualty, Subsequent 10 0 12 0 0 0 0 0 4 5 15 5 10 30 Fatality Immediate 0 0 11 10 0 0 2 0 2 1 20 0 0 10 Fatalities Casualty, 104 16 137 13 94 18 149 40 201 25 290 10 610 30 Surviving Casualty, Subsequent 1 0 0 0 0 0 0 0 0 0 0 0 0 0 Fatality Immediate 0 0 4 0 0 4 1 0 13 0 20 0 10 0 Fatalities Casualty, 314 16 279 5 131 4 326 9 519 6 597 10 1383 10 Surviving Casualty, Subsequent 0 0 0 0 0 0 2 0 0 0 0 0 0 0 Fatality Immediate 0 0 0 0 4 0 23 17 17 21 60 0 30 10 Fatalities Casualty, 359 27 311 27 150 40 357 84 559 127 664 35 1457 60 Surviving Casualty, Subsequent 0 0 0 0 8 0 1 0 0 0 0 0 0 0 Fatality 52 VX Casualties, TBMs (Heavy) VX Casualties, TBMs (Moderate) VX Casualties, TBMs (Light) VX Casualties, Bombs (Heavy) VX Casualties, Bombs (Moderate) VX Casualties, Bombs (Light) VX Casualties, Artillery/MRLS (Heavy) VX Casualties, Artillery/MRLS (Moderate) VX Casualties, Artillery/MRLS (Light) SubOperational Operational Area Area Table VIII-2. Summary of Casualty Scenarios, VX Heavy Brigade, Heavy Brigade, Heavy Brigade, Heavy Brigade, Brigade Heavy Brigade, Brigade Support Brigade Light Infantry Brigade Manuever Batallions, Manuever Batallions, Manuever Batallions, Support Area, Support Area, Offense Movement to Contact Offense Defense Movement to Contact or Defense 40 16 21 40 N/A 10 6 Length (Km) 20 24 45 20 N/A 7 6 Breadth (Km) 4,042 4,042 4,042 4,042 4,042 2,314 3,454 Population Maneuver Batallion Maneuver Batallion Maneuver Batallion Support Batallion Support Batallion N/A N/A Unit 10 10 15 10 6 Length (Km) 20 8 15 20 5 Breadth (Km) 1,047 1,047 1,047 1,013 1,013 Population Protection Protection Protection Protection Protection Protection Protection Protection Protection Protection Protection Protection Protection Protection Unavailable Available Unavailable Available Unavailable Available Unavailable Available Unavailable Available Unavailable Available Unavailable Available Immediate 0 0 5 5 3 3 0 0 6 6 95 95 96 96 Fatalities Casualty, 41 41 67 54 57 56 109 108 149 152 140 140 212 212 Surviving Casualty, Subsequent 0 0 0 0 1 0 0 0 3 0 10 0 0 0 Fatality Immediate 0 0 14 14 13 13 0 0 17 17 50 110 422 422 Fatalities Casualty, 77 35 113 107 93 91 171 171 213 192 185 145 370 300 Surviving Casualty, Subsequent 0 0 0 6 0 2 0 0 1 1 15 10 10 0 Fatality Immediate 0 0 13 18 11 25 0 12 205 19 55 85 620 686 Fatalities Casualty, 120 117 124 98 118 82 180 163 153 179 285 130 617 308 Surviving Casualty, Subsequent 0 0 2 5 1 0 0 9 7 0 20 5 30 50 Fatality Immediate 0 0 19 19 0 0 8 8 44 44 45 45 88 70 Fatalities Casualty, 75 70 105 102 70 69 131 131 150 150 240 230 494 464 Surviving Casualty, Subsequent 0 0 3 0 0 0 0 0 0 0 0 0 0 18 Fatality Immediate 92 92 52 52 4 4 45 45 66 62 150 150 130 120 Fatalities Casualty, 116 72 143 105 125 121 177 177 279 264 325 310 860 832 Surviving Casualty, Subsequent 0 0 0 0 0 0 0 0 8 8 0 0 0 10 Fatality Immediate 121 98 53 53 0 0 103 103 175 165 145 140 120 80 Fatalities Casualty, 145 141 192 142 127 121 187 190 259 263 367 360 1078 1021 Surviving Casualty, Subsequent 10 31 0 0 4 4 3 0 4 10 0 5 30 50 Fatality Immediate 25 8 123 7 0 11 165 44 104 20 184 95 188 126 Fatalities Casualty, 419 49 147 23 224 39 104 42 108 12 212 55 383 110 Surviving Casualty, Subsequent 25 0 9 0 0 0 0 0 2 6 5 5 0 0 Fatality Immediate 107 0 190 20 126 5 257 39 213 15 644 20 985 0 Fatalities Casualty, 691 26 113 18 223 23 121 28 105 42 247 25 382 30 Surviving Casualty, Subsequent 4 0 5 0 3 6 6 0 4 0 25 0 7 0 Fatality Immediate 107 4 175 26 193 33 242 1 220 60 564 85 1191 186 Fatalities Casualty, 584 56 107 31 178 39 111 76 164 89 237 85 339 140 Surviving Casualty, Subsequent 0 4 13 0 0 15 0 15 6 35 15 34 20 Fatality 53 Distilled Mustard (HD) Casualties, TBMs (Heavy) Distilled Mustard (HD) Casualties, TBMs (Moderate) Distilled Mustard (HD) Casualties, TBMs (Light) Distilled Mustard (HD) Casualties, Bombs (Heavy) Distilled Mustard (HD) Casualties, Bombs (Moderate) Distilled Mustard (HD) Casualties, Bombs (Light) Distilled Mustard (HD) Casualties, Artillery/MRLS (Heavy) Distilled Mustard (HD) Casualties, Artillery/MRLS (Moderate) Distilled Mustard (HD) Casualties, Artillery/MRLS (Light) SubOperational Operational Area Area Table VIII-3. Summary of Casualty Scenarios, HD Heavy Brigade, Heavy Brigade, Heavy Brigade, Heavy Brigade, Brigade Heavy Brigade, Brigade Support Brigade Light Infantry Brigade Manuever Batallions, Manuever Batallions, Manuever Batallions, Support Area, Support Area, Offense Movement to Contact Offense Defense Movement to Contact or Defense 40 16 21 40 N/A 10 6 Length (Km) 20 24 45 20 N/A 7 6 Breadth (Km) 4,042 4,042 4,042 4,042 4,042 2,314 3,454 Population Maneuver Batallion Maneuver Batallion Maneuver Batallion Support Batallion Support Batallion N/A N/A Unit 10 10 15 10 6 Length (Km) 20 8 15 20 5 Breadth (Km) 1,047 1,047 1,047 1,013 1,013 Population Protection Protection Protection Protection Protection Protection Protection Protection Protection Protection Protection Protection Protection Protection Unavailable Available Unavailable Available Unavailable Available Unavailable Available Unavailable Available Unavailable Available Unavailable Available Immediate 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Fatalities Casualty, 16 9 24 8 15 14 77 10 45 47 25 5 40 20 Surviving Casualty, Subsequent 0 0 5 0 15 0 0 6 33 2 5 0 20 0 Fatality Immediate 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Fatalities Casualty, 93 0 136 69 41 0 145 37 172 8 320 0 430 168 Surviving Casualty, Subsequent 0 0 0 20 2 0 0 11 0 4 0 0 0 58 Fatality Immediate 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Fatalities Casualty, 298 34 320 35 100 4 325 14 522 109 575 170 1148 274 Surviving Casualty, Subsequent 21 4 0 6 0 4 8 14 8 53 0 65 0 78 Fatality Immediate 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Fatalities Casualty, 38 38 7 31 11 20 0 57 24 73 5 35 20 80 Surviving Casualty, Subsequent 0 16 11 6 14 2 15 0 24 33 25 0 40 10 Fatality Immediate 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Fatalities Casualty, 62 77 16 75 17 76 71 136 10 178 45 140 40 210 Surviving Casualty, Subsequent 0 8 36 9 43 12 13 0 87 22 70 30 150 40 Fatality Immediate 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Fatalities Casualty, 32 63 17 80 10 93 22 97 19 153 30 205 56 346 Surviving Casualty, Subsequent 45 1 29 10 34 15 13 49 64 73 155 20 172 52 Fatality Immediate 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Fatalities Casualty, 27 20 4 17 28 18 39 33 41 40 20 25 30 30 Surviving Casualty, Subsequent 0 0 0 0 2 0 0 0 52 0 20 5 38 0 Fatality Immediate 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Fatalities Casualty, 40 9 54 4 29 8 81 25 95 20 65 10 130 35 Surviving Casualty, Subsequent 2 0 7 0 8 0 0 0 43 0 25 5 70 15 Fatality Immediate 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Fatalities Casualty, 23 9 80 17 47 8 132 25 136 20 85 10 66 35 Surviving Casualty, Subsequent 25 0 14 4 3 2 0 0 4 0 90 0 112 15 Fatality 54 IX. OBSERVATIONS AND CONCLUSIONS A. RECOMMENDATIONS FOR FUTURE VERSIONS OF AMedP-8 CHEMICAL Upon the review and analysis performed to document the production of AMedP-8 Chemical, it became clear that several points were open to revision with the production of a new AMedP-8 in the future. The objective of any revisions to AMedP-8 should be to significantly add to the value of the information provided by making that information more accessible and applicable, and/or to extend the information to more situations of interest. Making information in AMedP-8 more accessible implies changing either the way the information is presented or the format of the document. Currently, the information is presented in a series of tables formatted to permit printing as hard copies. Some reformatting suggestions are: Use hypertext to improve user access to information. This would retain the tabular format of the information, but make the electronic access to the data faster by a user interface, which requires a minimum of information to have the desired table display on the screen. Incorporate graphical presentation of data. This would supplement the tables with graphs. Some information is easier to grasp graphically. Of course, some information is difficult to graph. Implementing this change could significantly increase the size of AMedP-8. The challenge to the AMedP-8 Custodian is to determine the optimum balance and structure of graphical and tabular data presentation. Include supporting algorithms. This would allow the AMedP-8 user to algorithmically estimate performance fraction, fraction ill, time of onset, or time of death for any given exposure level. The difficulty in implementing this change is that there are currently no simple underlying algorithms for the information presented in AMedP-8. Deriving or developing supporting algorithms is associated with significant risk. Include supplementary software. This would allow the AMedP-8 user to estimate casualties for a multitude of situations. The difficulty in implementing this format change is that there is currently no generic software that does this. The closest available tool is the Casualty Estimation (CE) module of the NBC Casualty Resource Estimation Support Tool (CREST). If that is not acceptable, it would most likely be very difficult to develop a completely new software tool that adequately responds to the AMedP-8 users’ requirements. IDA recognizes that AMedP-8 is directly applicable to only the limited number of specific scenarios presented. To make information in AMedP-8 more applicable implies adding more information that responds directly to the specific technical requirements of 55 AMedP-6 and AMedP-7. This additional information could be a compilation of the medical treatment requirements (from AMedP-6) as applicable to the casualties in AMedP-8, or the derivation of the analytic tools of AMedP-7, which depend on the casualty estimates expressed in AMedP-8. The scenarios used in AMedP-8 are also limited in extent and applicability. The current AMedP-8 estimates casualties from a limited number of applications of military weapons against a limited selection of deployed military force scenarios. Extending the information in AMedP-8 to more situations of interest is one way to expand the utility of AMedP-8. Additional situations could include: B. Additional degrees of injury (negligible, moderate, severe, fatal) subcategories to a “casualty” definition. Each type of injury correlates to specific ranges of insults, which in turn drive medical system requirements. For example, in the “Severe Injury” category, personnel survive but require skilled medical care for six weeks or longer. Additional types of chemical agents Multiple attacks on single units Additional military deployment scenarios Additional environments for military operations (urban, forest, etc.) Terrorist use of chemical weapons against deployed military forces Military and/or terrorist use of chemical weapons against civilian populations Expanded demographic characterization of population Impact of protective measures and responses Physical protection, especially from tents, vehicles, etc. Medical protection Technical detection and medical surveillance Decontamination Medical care. CONCLUSIONS AMedP-8 Chemical added, for the first time, chemical casualty estimation to NATO’s medical and operational NBC capabilities. Building on the methodology and format developed and used in AMedP-8 Nuclear, it quantifies casualties by degree of exposure, and describes the injuries and their effect on personnel performance by time period. The documentation of AMedP-8 Chemical will provide a starting point for future revisions and will help users better understand its capabilities and limitations. While acknowledging that this is not a perfect document and that further work should be pursued to 56 improve its utility, AMedP-8 Chemical is a significant step toward preparedness for chemical warfare and terrorism. 57 X. DEFINITIONS ISC Exposure Insult Effective dose 58 APPENDIX A HEAVY BRIGADE, FORWARD MANEUVER, MOVEMENT TO CONTACT APPENDIX B HEAVY BRIGADE, BRIGADE SUPPORT AREA, MOVEMENT TO CONTACT APPENDIX C HEAVY BRIGADE, FORWARD MANEUVER, OFFENSE APPENDIX D HEAVY BRIGADE, FORWARD MANEUVER, DEFENSE APPENDIX E HEAVY BRIGADE, BRIGADE SUPPORT AREA, OFFENSE OR DEFENSE APPENDIX F SUPPORT BRIGADE APPENDIX G LIGHT INFANTRY BRIGADE APPENDIX H TOE INFORMATION A. Heavy Brigade, Forward Maneuver Battalion and Brigade Support Area, Movement to Contact Table H-1. Heavy Brigade FM & BSA Movement to Contact TOE # 44177L000, modified 63006L000 42004L100 43009L000 08058L100 05336L000 05337L000, modified 06366L200, modified 06367L200 Notes: B. Unit Air Defense Arty Battery Forward Support BN HQ&HQ Detachment FSB Supply Co FSB Ordnance Co FSB Medical Co FSB Engineer BN HHQ FSB Eng Co 1, Eng Co 2, Eng Co 3 FSB Field Arty Bn HHB Field Arty Batteries 1, 2 & 3 FLD TRN: In brigade with FSB CBT TRN: In battalion near rear MAINT: In battalion near rear In BSA: BDE HHC; FSB; FLD TRN Heavy Brigade, Brigade Support Area, Offense and Defense Table H-2. Heavy Brigade BSA Offense/Defense TOE # 44177L000, modified 63006L000 42004L100 43009L000 08058L100 05336L000 05337L000, modified 06366L200, modified 06369L100 Notes: Unit Air Defense Arty Battery Forward Support BN HQ&HQ Detachment FSB Supply Co FSB Ordnance Co FSB Medical Co FSB Engineer BN HHQ FSB Eng Co 1, Eng Co 2, Eng Co 3 FSB Field Arty BN HHB Service Battery FLD TRN: In brigade FSA CBT TRN: In battalion rear area MAINT: In battalion rear area C. Heavy Brigade, Forward Maneuver Battalion, Defense Table H-3. Heavy Brigade FM Defense TOE # 44177L000, modified 05337L000, modified 06366L200, modified 06367L200 Notes: Unit Air Defense Arty Battery(-) Eng Co 1 Field Arty BN HHB Field Arty Battery 1 CO TN: In company rear area CBT TN: In battalion rear area Assumptions: No effort has been made to show the support elements (maint, supply, medic, and mess) that would accompany the tank company when it joined the mech TF and the rifle company that departed, because the total numbers of vehicles and personnel would be the same for all practical purposes. The artillery battalion CP has been arbitrarily placed in the TF area as representative of brigade assets that would be located in the TF area. The number of icons could be larger or smaller, depending on terrain and mission. D. Heavy Brigade, Forward Maneuver Battalion, Offense Table H-4. Heavy Brigade FM Offense TOE # 44177L000, modified 05337L000, modified 06366L200, modified 06367L200 Notes: Unit Air Defense Arty Battery(-) Eng Co 1 Field Arty BN HHB Field Arty Battery 1 CO TN: In company rear area CBT TN: In battalion rear area Assumptions: No effort has been made to show the support elements (maint., supply, medic., and mess.) that would accompany the tank company when it joined the mech TF and the rifle company that departed, because the total numbers of vehicles and personnel would be the same for all practical purposes. The artillery battalion CP has been arbitrarily placed in the TF area as a representative of brigade assets that would be located in the TF area. The number of icons could be larger or smaller depending on terrain and mission. E. Light Infantry Brigade TOE information was not found during the documentation process for the Light Infantry Brigade. F. Support Brigade Table H-5. Support Brigade TOE # 42447L-010 42414L 43209L 55718LL 63426L 9483L 43007L 43008L 09008L100 42007L100 0857L100 Unit QM Supply Co FSC Direct Support Maint Co Lt Maint Co HHD CSB DS Ammo Co Light Ord Maint Co Heavy Ord Maint Co Ord Missile Maint Supply & Service Co Med Co APPENDIX I DATA PROCESSING A. Input Data Overview This appendix details the inputs of the BioStrike and VLSTRACK models, used during the production of AMedP-8 Chemical. Figure I-1 demonstrates the flow of data that led to casualty estimates. Agent, munitions, and meteorological data were used by the IDA variant of VLSTRACK, GRIDGEN, to model the agent cloud. This agent cloud was then input into BioStrike and, together with attack points and troop data files, was used by BioStrike to determine the chemical agent exposure to individuals in each AMedP-8 scenario. Attack Point Troop Data Meteorological Data Agent Data Munitions Data VLSTRACK (Gridgen) Biostrike Agent Cloud Exposure to Individuals Figure I-1. Data Processing Overview B. BioStrike Inputs 1. Troop Data The following input files were used to enter troop data into BioStrike. Each file pertains to one of seven scenarios, as explained in Table I-1. Each file includes grid point numbers, the x,y coordinates for each grid point, and number of troops at that location. The troop files were called POSTM55.TRP, POSTM64.TRP, POSTM74.TRP, POSTM81.TRP, POSTM82.TRP, POSTM83.TRP, and POSTM97.TRP. POSTM81.TRP contains the troop data for the Heavy Brigade in Movement to Contact, without a specific targeted area. Note that grid point numbers correspond to icon numbers for these scenarios. Table I-1. Scenario Labels for Troop Files LABEL UNIT TYPE AREA TARGETED MISSION 83 Heavy Brigade Forward Maneuver Battalions Movement to Contact 97 Heavy Brigade Forward Maneuver Battalions Offense 74 Heavy Brigade Forward Maneuver Battalions Defense 82 Heavy Brigade Brigade Support Area Movement to Contact 55 Heavy Brigade Brigade Support Area Offense or Defense 64 Support Brigade N/A Support 67 Light Infantry Brigade N/A Defense 2. Attack Points For each scenario, attack points were determined via the optimization process described in Section III.B.2. These attack points have been tabulated for the protected and unprotected cases of each scenario/agent combination. For each attack, the table provides information on the x,y coordinates of the attack point, the particular type of munitions used, the number of rounds fired, and the height of release of the agent in that attack. Tables I-2 through I-22 are organized by agent. GB Attack Points Table I-2. GB Attack Points: Heavy Brigade, Forward Maneuver, Movement to Contact GB Attack Points Heavy Brigade, Forward Maneuver Battalions, Movement to Contact Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 20.25 34.00 0m 20.55 35.35 0m 18.30 20.15 0m 20.45 34.80 0m 18.10 20.10 0m 18.75 20.25 0m 17.55 20.30 0m 17.80 20.10 0m 17.95 21.45 0m Protected 10.55 43.45 0m 20.60 33.25 0m 20.70 32.70 0m 16.50 23.00 0m 20.45 33.25 0m 20.45 33.25 0m 10.55 35.15 0m 20.75 44.55 0m 20.45 33.00 0m Table I-3. GB Attack Points: Heavy Brigade, Brigade Support Area, Movement to Contact GB Attack Points Heavy Brigade, Brigade Support Area, Movement to Contact Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 17.60 15.45 0m 17.80 16.80 0m 17.95 17.9 0m 17.65 16.15 0m 18.80 19.05 0m 17.65 19.55 0m 17.60 17.00 0m 17.75 19.95 0m 17.75 20.00 0m Protected 17.80 18.50 0m 17.90 14.55 0m 17.60 15.30 0m 17.35 14.75 0m 17.70 14.75 0m 17.65 18.45 0m 17.70 18.65 0m 13.75 20.00 0m 17.10 14.90 0m Table I-4. GB Attack Points: Heavy Brigade, Forward Maneuver, Offense GB Attack Points Heavy Brigade, Forward Maneuver Battalion, Offense Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 17.60 15.60 0m 10.80 44.50 0m 8.50 50.00 0m 10.70 43.80 0m 9.00 50.50 0m 8.90 51.80 0m 9.00 50.50 0m 8.90 51.80 0m 8.80 53.90 0m Protected 9.10 48.30 0m 9.20 48.30 0m 10.70 49.90 0m 8.90 48.20 0m 10.70 50.70 0m 10.70 50.90 0m 9.30 45.80 0m 12.60 49.70 0m 8.00 48.30 0m Table I-5. GB Attack Points: Heavy Brigade, Forward Maneuver, Defense GB Attack Points Heavy Brigade, Forward Maneuver, Defense Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 10.80 38.20 0m 10.70 39.60 0m 10.80 40.50 0m 10.90 39.20 0m 10.70 40.50 0m 10.70 41.90 0m 10.80 40.50 0m 10.60 42.10 0m 11.60 52.00 0m Protected 6.70 41.20 0m 11.10 37.60 0m 10.70 37.90 0m 13.30 48.60 0m 10.70 37.70 0m 10.50 37.60 0m 13.40 48.70 0m 8.30 50.80 0m 8.60 46.90 0m Table I-6. GB Attack Points: Heavy Brigade, Brigade Support Area, Offense and Defense GB Attack Points Heavy Brigade, Brigade Support Area, Offense or Defense Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 15.50 19.10 0m 16.00 18.90 0m 16.20 20.00 0m 15.50 19.70 0m 15.90 20.00 0m 15.90 19.60 0m 15.50 20.00 0m 15.60 20.00 0m 15.60 20.00 0m Protected 15.60 18.40 0m 16.40 16.70 0m 15.40 18.90 0m 16.30 16.50 0m 15.50 18.40 0m 15.80 16.90 0m 15.60 18.40 0m 15.70 18.10 0m 15.20 18.60 0m Table I-7. GB Attack Points: Support Brigade GB Attack Points Support Brigade Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 17.40 24.80 0m 17.50 26.10 0m 18.00 25.60 0m 17.40 25.70 0m 17.20 26.90 0m 17.20 28.10 0m 17.30 26.70 0m 17.50 28.60 0m 17.70 29.00 0m Protected 16.30 23.50 0m 17.40 24.30 0m 17.30 24.60 0m 12.20 22.30 0m 17.40 24.00 0m 17.50 24.00 0m 16.50 27.50 0m 10.60 24.40 0m 18.70 25.10 0m Table I-8. GB Attack Points: Light Infantry Brigade GB Attack Points Light Infantry Brigade Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 5.90 13.90 0m 5.70 15.20 0m 5.50 16.20 0m 5.80 15.00 0m 5.70 16.30 0m 5.70 17.30 0m 5.80 16.40 0m 5.30 17.50 0m 5.30 18.00 0m Protected 5.90 13.10 0m 5.70 13.10 0m 5.70 14.40 0m 5.30 16.30 0m 5.80 12.90 0m 5.80 14.30 0m 6.00 13.00 0m 4.90 12.10 0m 7.60 13.10 0m VX Attack Points Table I-9. VX Attack Points: Heavy Brigade, Forward Maneuver, Movement to Contact VX Attack Points Heavy Brigade, Forward Maneuver Battalions, Movement to Contact Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 18.70 20.30 15m 20.60 34.70 15m 20.45 35.30 15m 17.95 20.60 70m 18.75 20.30 70m 17.65 20.15 70m 18.40 35.30 500m 17.40 31.40 800m 17.75 46.95 800m Protected 17.70 20.30 15m 20.60 34.70 15m 20.45 35.00 15m 17.95 20.60 70m 18.75 20.30 70m 17.65 20.15 70m 17.90 20.15 500m 20.70 33.85 800m 18.15 20.15 800m Table I-10. VX Attack Points: Heavy Brigade, Brigade Support Area, Movement to Contact VX Attack Points Heavy Brigade, Brigade Support Area, Movement to Contact Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 17.60 15.80 15m 17.70 16.20 15m 17.85 16.85 15m 17.65 17.60 70m 17.60 18.20 70m 17.65 20.00 70m 17.90 20.00 500m 19.65 19.90 800m 18.30 20.00 800m Protected 17.60 15.80 15m 17.70 16.15 15m 17.90 16.40 15m 17.65 17.60 70m 17.60 18.20 70m 17.65 20.00 70m 17.65 16.30 500m 17.95 15.25 800m 18.00 15.65 800m Table I-11. VX Attack Points: Heavy Brigade, Forward Maneuver, Offense VX Attack Points Heavy Brigade, Forward Maneuver Battalion, Offense Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 10.90 43.55 15m 10.75 43.80 15m 10.80 44.50 15m 9.10 50.60 70m 8.95 51.85 70m 9.15 52.00 70m 10.40 52.00 500m 8.65 52.00 800m 9.65 51.40 800m Protected 10.90 43.55 15m 10.75 43.75 15m 10.90 44.10 15m 9.10 50.60 70m 8.95 51.85 70m 9.15 52.00 70m 10.65 43.95 500m 10.75 43.1 800m 10.20 48.50 800m Table I-12. VX Attack Points: Heavy Brigade, Forward Maneuver, Defense VX Attack Points Heavy Brigade, Forward Maneuver, Defense Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 10.80 38.70 15m 10.60 38.90 15m 10.55 39.55 15m 10.70 40.30 70m 10.70 41.10 70m 10.70 41.85 70m 10.90 59.80 500m 10.50 58.80 800m 11.70 59.90 800m Protected 10.80 38.70 15m 10.60 38.90 15m 10.55 39.55 15m 10.70 40.30 70m 10.70 41.10 70m 10.70 41.85 70m 11.00 38.55 500m 8.95 47.5 800m 10.50 39.45 800m Table I-13. VX Attack Points: Heavy Brigade, Brigade Support Area, Offense and Defense VX Attack Points Heavy Brigade, Brigade Support Area, Offense or Defense Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 15.50 19.45 15m 15.40 19.80 15m 16.20 18.85 15m 16.10 18.25 70m 15.90 19.60 70m 15.90 19.45 70m 15.50 19.70 500m 14.60 20.00 800m 15.60 19.90 800m Protected 15.50 19.45 15m 15.45 19.80 15m 16.05 20.00 15m 16.10 18.25 70m 15.90 19.60 70m 15.90 19.45 70m 15.50 19.00 500m 15.45 19.15 800m 15.20 20.00 800m Table I-14. VX Attack Points: Support Brigade VX Attack Points Support Brigade Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 17.30 24.95 15m 17.35 25.50 15m 17.70 26.20 15m 17.35 27.10 70m 17.35 28.20 70m 17.35 29.20 70m 16.80 30.00 500m 19.30 30.00 800m 17.95 29.00 800m Protected 17.30 24.95 15m 17.50 25.65 15m 17.75 25.75 15m 17.35 27.10 70m 17.35 28.20 70m 17.35 29.20 70m 17.35 25.50 500m 17.70 24.20 800m 17.55 25.50 800m Table I-15. VX Attack Points: Light Infantry Brigade VX Attack Points Light Infantry Brigade Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 5.60 14.20 15m 5.70 14.65 15m 5.50 15.15 15m 5.85 16.40 70m 5.65 17.35 70m 5.65 18.00 70m 6.40 18.00 500m 7.65 18.00 800m 6.25 17.95 800m Protected 5.60 14.20 15m 5.70 14.65 15m 5.65 14.75 15m 5.85 16.40 70m 5.65 17.35 70m 5.65 18.00 70m 6.40 18.00 500m 5.70 13.55 800m 5.90 15.70 800m HD Attack Points Table I-16. HD Attack Points: Heavy Brigade, Forward Maneuver, Movement to Contact HD Attack Points Heavy Brigade, Forward Maneuver Battalions, Movement to Contact Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 10.55 43.65 15m 17.80 21.15 15m 18.25 24.40 15m 20.40 33.65 70m 20.55 33.75 70m 20.55 33.85 70m 20.40 33.80 500m 20.50 34.10 800m 20.50 34.05 800m Protected 13.35 41.15 15m 21.25 45.55 15m 18.25 20.00 15m 20.40 33.65 70m 20.55 33.60 70m 20.55 33.90 70m 20.30 33.45 500m 6.30 44.15 800m 6.10 44.15 800m Table I-17. HD Attack Points: Heavy Brigade, Brigade Support Area, Movement to Contact HD Attack Points Heavy Brigade, Brigade Support Area, Movement to Contact Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 17.55 14.85 15m 17.85 19.55 15m 18.25 20.00 15m 17.60 15.00 70m 17.65 15.20 70m 17.65 15.50 70m 17.65 15.20 500m 17.95 15.45 800m 17.50 15.95 800m Protected 10.75 19.65 15m 17.75 17.35 15m 18.75 18.10 15m 17.65 14.90 70m 17.65 15.05 70m 17.65 15.40 70m 17.55 14.95 500m 14.60 15.50 800m 14.20 16.15 800m Table I-18. HD Attack Points: Heavy Brigade, Forward Maneuver, Offense HD Attack Points Heavy Brigade, Forward Maneuver Battalion, Offense Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 7.85 48.60 15m 9.00 52.00 15m 10.70 52.00 15m 7.75 48.65 70m 10.70 42.80 70m 10.70 43.10 70m 10.90 42.85 500m 10.60 43.25 800m 10.35 47.55 800m Protected 9.10 46.85 15m 9.20 48.50 15m 9.05 50.95 15m 10.60 42.70 70m 10.65 42.70 70m 10.65 42.90 70m 10.50 42.70 500m 6.10 50.00 800m 11.25 42.25 800m Table I-19. HD Attack Points: Heavy Brigade, Forward Maneuver, Defense HD Attack Points Heavy Brigade, Forward Maneuver, Defense Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 8.50 47.20 15m 10.75 44.65 15m 11.20 52.65 15m 8.35 47.40 70m 10.70 37.75 70m 10.55 38.15 70m 10.85 44.65 500m 10.60 38.55 800m 11.35 37.95 800m Protected 6.75 41.10 15m 10.75 39.80 15m 10.55 39.60 15m 8.35 47.40 70m 10.65 37.75 70m 10.70 37.95 70m 13.50 48.75 500m 8.05 50.85 800m 11.35 37.95 800m Table I-20. HD Attack Points: Heavy Brigade, Brigade Support Area, Offense and Defense HD Attack Points Heavy Brigade, Brigade Support Area, Offense or Defense Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 15.65 18.45 15m 15.90 19.80 15m 15.80 20.00 15m 15.50 18.60 70m 15.40 18.70 70m 15.40 19.05 70m 15.60 18.75 500m 15.25 19.30 800m 15.25 19.60 800m Protected 16.10 16.60 15m 15.40 20.00 15m 15.95 19.35 15m 15.45 18.55 70m 15.45 18.55 70m 15.35 18.90 70m 16.20 16.70 500m 15.55 17.45 800m 15.55 17.45 800m Table I-21. HD Attack Points: Support Brigade HD Attack Points Support Brigade Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 17.30 24.00 15m 17.55 28.10 15m 17.90 30.00 15m 17.40 24.40 70m 17.35 24.45 70m 17.35 24.55 70m 17.30 24.55 500m 17.65 24.75 800m 17.15 25.20 800m Protected 12.30 25.05 15m 17.50 25.90 15m 17.65 25.10 15m 17.30 24.70 70m 17.35 24.35 70m 17.35 24.65 70m 17.35 24.20 500m 12.10 22.60 800m 11.70 23.25 800m Table I-22. HD Attack Points: Light Infantry Brigade HD Attack Points Light Infantry Brigade Munition # of rounds 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 152mm Artillery MRLS MRLS 250kg Bomb 250kg Bomb 250kg Bomb 250kg TBM 500kg TBM 500kg TBM 18 240 720 2 12 24 1 2 4 X-wind Upwind Height of Release Unprotected 6.00 14.55 15m 5.70 17.85 15m 6.15 18.00 15m 5.50 14.20 70m 5.65 13.25 70m 5.75 14.65 70m 6.00 14.55 500m 5.70 13.90 800m 5.80 14.70 800m Protected 4.60 14.55 15m 5.75 15.05 15m 5.55 15.15 15m 5.65 13.35 70m 5.65 13.35 70m 5.65 13.80 70m 5.85 15.00 500m 4.90 13.40 800m 4.90 13.40 800m C. VLSTRACK Inputs 1. Agent Characteristics During the production of casualty estimates for AMedP-8 Chemical, the values in Table I-23 were used as VLSTRACK inputs for chemical agent properties. In most cases, these values correspond to VLSTRACK defaults. According to VLSTRACK documentation, the physical properties for agents addressed by the model were listed in a file named VLSAGN.PAR.32 Table I-23. VLSTRACK Agent Characteristics33 Characteristic Definition Bulk Density (g/cm3) The density for neat chemical agents in liquid form. Dissemination Efficiency (%) The percent of the bulk munition fill that is effectively dispersed into the atmosphere (the remainder is destroyed by the detonation). Median Effective Dose (mg) Typically referred to as ED50; the dose required to cause effects in 50% of the population exposed to that dose. For chemical agents, ED50 is generally measured in milligrams (mg). Probit Slope Expressed in base-10, the slope of the curve used to represent human response to doses of harmful substances; in this case, the y-axis is the administered dose, and the x-axis is the probability of response. Freezing Temperature (oC) The temperature at which a material freezes; same as Freezing Point. Molecular Weight (g/mole) Mass in grams of one mole of molecules; the same as molar mass. Volatility Coefficients With molecular weight and air temperature data, used to calculate volatility of persistent chemical agent. Heat of Vaporization (cm2/s2) Heat of vaporization is energy absorbed during the change of a mole of liquid to a vapor without a change in temperature. Viscosity (g/cm-s) The tendency of a fluid to resist internal flow without regard to its density. Surface Tension (dyne/cm) The tangential force acting at the interface between a liquid and air (or, more correctly, its own vapor) caused by the difference in attraction between liquid molecules and gaseous molecules. (Also called surface energy, surface free energy, capillary forces, interfacial tension.)34 Agent Vapor Diffusivity in Air (cm2/s) Droplet Spread Factor 32 The rate at which agent vapor diffuses. The ratio of droplet diameter for a droplet on the ground to that of a droplet falling at its terminal velocity in the air. Bauer et al., 1995 Unless noted otherwise, the definitions of data categories provided here are taken from Bauer, Timothy, op. cit., pp. 3-79 to 3-85. 34 amsglossary.allenpress.com/glossary/browse 33 Type Category Bulk Density (g/cm3) Dissemination Efficiency Probit Slope Freezing Temp (C) - Persistent/ Dusty Boiling Temp (C) - Dense Gas ATP-45 NBC Message Term Molecular Weight (g/mole) Volatility Coefficient 1 Volatility Coefficient 2 Volatility Coefficient 3 Heat of Vaporization (cm2/s2) Viscosity (g/cm-s) Surface Tension (dyne/cm) Agent Vapor Diffusivity in Air (cm2/s) Droplet Spread Factor VX 1 1.01 60 30 6.30 -50 'VX' 267.4 7.28 2072.1 172.5 3.39E+09 0.123 32.0 0.033 3.5 GB (Sarin) GB 1 1.09 60 70 12.00 -57 'GB' 140.1 7.48 1773.8 227.9 3.35E+09 0.014 28.8 0.059 3.5 HD (Mustard) HD 1 1.27 60 1000 5.70 9 'HD' 159.1 7.47 1935.5 204.2 3.89E+09 0.045 43.2 0.057 3.5 LD50 Agent Abbr. VX (mg-min/m3) Agent Name Table I-24. VLSTRACK Agent Values 2. Munitions Characteristics During the production of casualty estimates for AMedP-8 Chemical, the values in Table I-24 were used as VLSTRACK inputs for munitions properties. In many cases, these values correspond to VLSTRACK defaults. According to VLSTRACK documentation, the physical properties for munitions used by the model were listed in a file named VLSMUN.PAR.35 For each munitions type, Typical Height of Burst is also listed in the VLSMUN.PAR file, but has been omitted from Table I-24. Typical Height of Burst values differed from VLSTRACK default values and can be found in Tables I-2 through I-22. For each agent/munitions combination SAIC optimized height of burst, and the optimization methodology was not available for documentation. Values in the category Typical Number of Munitions in Attack also differed from VLSTRACK default values. In Table I-24, one, two, or three values are listed for each munition type, indicating the number of attacks conducted with that munitions type in AMedP-8 Chemical. For example, three attacks were conducted with 250kg bombs; one attack employed 2 rounds (light attack), another employed 12 rounds (moderate attack), and a third employed 24 rounds (heavy attack). However, only one attack was considered using the 250kg TBM, employing one round. Table I-25. Delivery System and Munitions Characteristics36 Characteristic 35 36 Definition Bauer et al., 1995 The definitions of characterisitics provided here are taken from Bauer, Timothy, op. cit., pp. 3-76 to 3-78. Fill Weight (kg) The weight of the agent fill contained in the munitions, at 1.0 g/cm3. For given agent, fill weight is multiplied by bulk density to determine the actual weight of agent used. Height of Burst (m) The altitude at which the munitions explodes or otherwise releases agent. Firing Rate (rounds/min) For munitions typically delivered in volleys, such as artillery shells, the rate at which they are fired at their target. Number of Munitions in Attack The number of munitions expected in a single volley. Downrange and Crossrange Target Standard Deviations (m) These values represent the accuracy of detonation coordinates relative to the target. Droplet Mass-Median Diameter (microns) For chemical agents, this value is typically a function of the munition fuzing and similar among munitions of a given type. Droplet Distribution Sigma For chemical agents, this value is typically a function of the munition fuzing and similar among munitions of a given type. Line Source Length (m) The length of the line along which the payload of a large delivery system (such as bombs or missiles) is released, if release occurs above ground at high velocity, and if the munition is appropriately fuzed. Line Source Fall Angle (degrees) The angle between the horizontal and the line along which agent is released. Cloud Sigma Values used to represent the trivariate Gaussian distribution of mass away from the detonation point. For single point releases, these values are defined for both vertical and horizontal spread. For line sources, a single value is used to represent the radial distribution away from the axis of the line source. Table I-26. VLSTRACK Delivery System and Munitions Data Typical Number of Munitions in Attack Typical Firing Rate (rds/min) Fill Weight (kg) (at 1.0 g/cm3) ATP-45 NBC Message Munition Term Point Source Horizontal Cloud Sigma (m) Point Source Vertical Cloud Sigma (m) Downrange Target Standard Deviation (m) Crossrange Target Standard Deviation (m) Neat Agent Droplet MassMedian Diameter (MMD) (microns) Thickened Agent Droplet Mass-Median Diameter (MMD) (microns) Geometric Droplet Distribution Sigma Line Source Cloud Sigma (m) 18 10 4 'SHL' 3 1.3 100 100 150 750 1.7 N/A N/A N/A MRLS (122mm Rocket) GB/VX/HD 1 240/ 720 0 9 'SHL' 2 1.2 100 100 150 750 1.7 N/A N/A N/A 250kg Bomb GB/VX/HD 2 002/ 012/ 024 4 75 'BOM' 14 6 150 50 500 2500 1.7 8 50 45 500kg TBM GB/VX/HD 3 002/ 004 1 500 'MSL' 6 N/A 500 500 100 500 1.7 N/A 200 45 250kg TBM GB/VX/HD 3 1 1 250 ' ' 6 N/A 999 999 100 500 1.7 N/A 200 45 3. Line Source Fall Angle (deg) Munition Type Category 1 Line Source Length (m) Fill Agent Abbr. GB/VX/HD Munition Name 152mm Artillery Meteorology Characteristics In AMedP-8 Chemical, worst-case meteorological conditions were assumed during the calculation of casualty estimates.37 Table I-25 lists the wind speed, temperature, local attack time, and cloud cover information used for each agentmunitions combination. In addition to the meteorology characteristics listed in Table I27, VLSTRACK also requires latitude and longitude coordinates to calculate the sun angle. Table I-27. VLSTRACK Meteorology Characteristics38 Characteristic Definition Wind Direction In degrees true North (DTN), where 0 DTN is to the North (from the South), 90 DTN is to the East (from the West), 180 DTN is to the South (from the North), and 270 DTN is to the West (from the east). Wind Speed (km/hr) For wind speeds less than 1.8 km/hr, VLSTRACK uses a wind meander approach where it assigns a random wind direction for each time step. Air Temperature (OC) A negative air temperature is subtracted from 50 to result in a number from 51 to 99. Degree of Cloud Cover In VLSTRACK, this is represented by selecting from “clear,” “partly cloudy,” and “overcast.” Pasquill Stability Category This is a characterization of atmospheric stability and ranges from very stable (category 7) to very unstable (category 1). If the user sets the stability category to 0, the program will calculate atmospheric stability from other meteorological inputs, time of day, and location on the globe. 37 38 Please refer to Section II.B.3 for an explanation of worst-case meteorological conditions. Bauer et al., 1995 Table I-28. VLSTRACK Meteorology Values Agent GB Dissemination Munition Attack Intensity MRLS/artillery Rounds Light (x18) Mod. (x240) Heavy (x720) Light (2x 250 kg) Moderate (12 x 250 kg) Heavy (24x 250 kg) Light (1x 250 L) Moderate (2x 500 L) Heavy (4x 500 L) Light 3 6 10 4 Moderate Heavy Light Moderate Heavy Light Moderate Heavy Light 8 8 30 30 30 4 4 6 0 Moderate Heavy Light Moderate Heavy Light Moderate Heavy 0 2 22 20 20 0 0 0 Bomb TBM VX MRLS/artillery Rounds Bomb TBM HD Weather Conditions MRLS/artillery Rounds Bomb TBM Wind Speed Temperature (Season) Local Attack Time Cloud Cover 16-25OC (Autumn) 1900 Clear 24-32OC (Summer) 1900 Partly Cloudy 24-32OC (Summer) 1900 Partly Cloudy 5-12OC (Winter) 0500 Clear 24-32OC (Summer) 0500 Partly Cloudy 24-32OC (Summer) 1200 Clear 5-12OC (Winter) 1200 Clear 9 10 8 10 12 14 APPENDIX J DETERMINATION OF EFFECTIVE DOSE A. Definitions and Variables Effective Dose (ED): an estimate of the equivalent vapor exposure (or dosage) level which produces severe effects corresponding to those produced by simultaneous exposure to two different types and/or forms of insult (i.e., liquid and aerosol) ICt50: the time-integrated agent vapor concentration that will produce severe effects in 50% of the exposed population; may refer to inhalation effects and/or percutaneous and eye exposures [measured in mg-min/m3] ED50: the liquid agent mass that will produce severe effects in 50% of the exposed population – assumes the typical population is represented by a 70 kg man assumed to have agent deposited over a 1 m2 surface of the body [measured in mg/man] ICt50(GB/IH/V): median exposure values that cause serious effects from inhaling (IH) the vapor (V) form of GB; this is similar for inhalation and percutaneous (PC) exposures resulting from vapor concentrations of VX and HD ED50(GB/PC/L): median exposure values that cause serious effects from percutaneous (PC) exposure to the liquid (L) form of GB; this is similar for percutaneous exposures resulting from liquid concentrations of VX and HD D(VX/IH/V): downwind exposure level from inhaling (IH) the vapor (V) form of VX ED(GB/IH/V): calculated effective dose due to the inhalation (IH) of the vapor (V) form of GB which would produce corresponding effects as a result of exposure to both vapor and liquid insults D v: vapor dose (mg-min/m3) D l: liquid dose (mg/man) D1v: first period (1 min) vapor dose (mg-min/m3) as given by VLSTRACK D2v: second period (8 min) vapor dose (mg-min/m3) as given by VLSTRACK D1l: first period (1 min) liquid dose (mg/man) as given by VLSTRACK – for conversion from VLSTRACK deposition values, multiply by 1m2/man D2l: second period (8 min) liquid dose (mg/man) as given by VLSTRACK – for conversion from VLSTRACK deposition values, multiply by 1m2/man Dav: first period vapor dose (mg-min/m3) as used in the DICE algorithm – for protection available, equal to D1v – applies to systemic (GB,VX) or respiratory, systemic and ocular (HD) exposure only Dal: first period liquid dose (mg/ m2*1m2/man) as used in the DICE algorithm – for protection available, equal to D1l – applies to systemic (GB,VX) or respiratory, systemic and ocular (HD) exposure only Dbv: combined first and second period VLSTRACK vapor dose (mg-min/m3) as used in the DICE algorithm – for protection available, equal to D1v + D2v(1 – a) – applies to systemic (GB,VX) or skin (HD) exposure only Dbl: combined first and second period VLSTRACK liquid dose (mg/ m2*1m2/man) as used in the DICE algorithm – for protection available, equal to D1l + D2l(1 – a) – applies to systemic (GB,VX) or skin (HD) exposure only F: factor which converts percutaneous vapor and liquid doses to effective inhalation doses (1– a): fraction (.93) of the body that is assumed to be unprotected by the mask and hood during the second period (prior to total protection by overgarments) B. Notes 1. Estimates of performance are made as a function of dose level and postexposure time, so it is important to determine dose level for each agent. 2. An effective dose calculation is used when the agent insult takes more than one form and/or exposure to the agent produces multiple and varied effects (i.e., systemic/respiratory, ocular and skin). In addition, the effective dose formulation is used to put VX exposure in terms of GB exposure for reasonable comparison; this was necessary because at the time of document production, no VX sign and symptom information was available. 3. Effective dose calculations vary depending on whether protection is or is not available. a. If protection is assumed to be unavailable, only the battle dress uniform (BDU) is assumed with no overgarment protection; the BDU is assumed to offer no protective effect and personnel are exposed to both liquid and vapor forms of the agent. b. If protection is assumed to be available, it is assumed: 1) During the first minute following the arrival of the agent cloud, personnel are not protected by any overgarments; 2) During the following eight minutes, personnel are protected by wearing a mask (and the associated hood) which provides 100% inhalation and ocular protection, as well as protection for 7% of the skin; 3) After nine minutes, personnel are protected from all forms of agent exposure by the complete overgarment at the MOPP 4 level; overgarment is assumed to be 100% effective in preventing exposure. 4. For the protection unavailable case, the vapor and liquid doses are assumed to be constant, so: a. Dv = D1v = D2v = Dav = Dbv b. Dl = D1l = D2l = Dal = Dbl 5. The breathing rate for all troops during the exposure period is assumed to be 15 l/min. 6. The following additional assumptions apply: a. Exacerbation of 1st period exposure by protective gear trapping agent next to the skin during the 2nd and 3rd periods is not considered. b. Encumbrance, heat stress, and possible skin irritation caused by wearing MOPP 4 gear are not considered. c. Entire dosage received during the protection unavailable period is assumed to be short-term exposure (10 min or less). d. Pickup of liquid agent by contact with the contaminated environment is not considered. C. Human Response Calculations The Institute for Defense Analyses calculated exposure data with Vapor, Liquid, and Solid Tracking (VLSTRACK) clouds used in BioStrike. They provided scenario-specific exposure data for GB, VX, and HD attacks to Pacific-Sierra Research Corporation (PSR). PSR used these values with the DICE algorithms (further described in Appendix L) to determine performance degradation, numbers of casualties over time, and fatalities. The equations below show the effective dose calculations both as they would be used with the VLSTRACK/Biostrike data and as the data was converted for use in the DICE algorithm. VLSTRACK provides both vapor concentration clouds in mg-min/m3 and liquid deposition on a horizontal surface in mg/m2 for chemical warfare agents. Clouds generated in VLSTRACK were utilized as inputs in BioStrike to determine the dose received by individuals in each formation. Effective vapor doses needed to be determined because the DICE algorithms were developed for use with vapor exposure only. a. Effective Dose Calculation for GB To determine the effective dose for GB, the following equations were used for the unprotected and protected cases, respectively. EDGB w/o protection = Dv + DvFa + DlFb EDGB w/protection = D1v(1+ Fa) + D2v(1 – a)Fa + D1lFb + D2l(1 – a)Fb Fa and Fb are factors for converting percutaneous GB vapor and liquid exposures to comparable inhalation values for use in the DICE algorithm. The ICt50 and ED50 values can be determined from Figures J-1 and J-2, shown below. The following are the calculated values of Fa and Fb: Fa = ICt50(GB/IH/V)/ICt50 (GB/PC/V) = 35/8000 = .0044 Fb = ICt50(GB/IH/V)/ED50(GB/PC/L) = 35/1000 = .035 Figure J-1. Inhalation and Ocular Dose response for GB vapor exposure endpoints39 Figure J-2. Percutaneous Dose response for GB vapor and liquid exposure endpoints For GB, the AMedP-8 working group decided to neglect liquid exposure. Although it is not specifically stated in the original documents, we believe this was due to the liquid exposure concentration of the generated GB clouds being below the minimum VLSTRACK measurable concentration values. Neglecting GB liquid exposure results in the following equation: 39 All dose response curve graphs from McClellan et al., 1998. EDGB w/o protection = Dv (1 + Fa) EDGB w/protection = D1v + [D1v + D2v(1 – a)]Fa In order to make the IDA data from Biostrike usable in the PSR model, the equation above needs to be converted to the Biostrike output format: Without Protection: EDGB w/o protection = Dav (1 + Fa) With Protection: EDGB w/protection = Dav + DbvFa EDGB w/protection (0-1 min, inhalation) = Dav EDGB w/protection (0-9 min, percutaneous) = DbvFa This effective dose is used to determine the severity of all symptom categories for GB exposure. 2. Effective Dose Calculation for VX To determine the effective dose for VX, as previously discussed, the VX values must first be converted to equivalent vapor doses for GB. The following equations were used for the unprotected and protected cases respectively. EDVX w/o protection = Dv(Fc + Fd) + DlFe EDVX w/protection = D1v(Fc + Fd) + D2v(1 – a)Fd + D1lFe + D2l(1 – a)Fe Fc, Fd, and Fe are factors for converting inhalation VX and percutaneous VX vapor and liquid exposures to comparable GB inhalation values for use in the DICE algorithm. Please note that the equation for Fc as given in the reference is: Fc = ICt50 (GB/IH/V)/ICt50 (GB/PC/L) = 35/25 = 1.4 Upon review, it became apparent that there was a typographical error in the document. The correct equation appears to be the one given below. The numerical values above are correct for the calculation of Fc; only the reference to the ICt50 of percutaneous GB in liquid form is incorrect. Rather, the equation should convert the ICt50 of inhaled vapor VX. The ICt50 and ED50 values can be determined from Figures J-3 and J-4, shown below. The following are the calculated values of Fc, Fd, and Fe: Fc = ICt50 (GB/IH/V)/ICt50 (VX/IH/V) = 35/25 = 1.4 Fd = ICt50 (GB/IH/V)/ICt50 (VX/PC/V) = 35/25 = 1.4 Fe = ICt50 (GB/IH/V)/ED50 (VX/PC/L) = 35/5 = 7 Figure J-3. Inhalation and Ocular Dose response for VX vapor exposure endpoints Figure J-4. Percutaneous Dose response for VX vapor and liquid exposure endpoints In order to make the IDA data from Biostrike usable in the PSR model, the equation above needs to be converted to the Biostrike output format: Without Protection: EDVX w/o protection = Dav(Fc + Fd) + DalFe Without Protection: EDVX w/protection = DavFc + DbvFd + DblFe EDVX w/protection (0-1 min, inhalation) = DavFc EDVX w/protection (0-9 min, percutaneous) = DbvFd + DblFe These effective dose calculations determine the severity of all symptom categories for VX in terms of the equivalent GB exposure; in order to calculate the equivalent injury severity category, the EDvx should be entered into the GB injury severity table (Table IV-1), vice the VX injury severity table (Table IV-2). In addition, these values are used in the DICE algorithms for GB as if representing GB vapor dosages. 3. Effective Dose Calculation for HD Because of its effects on various systems, the effective dose calculations for HD are more complex. For the HD cases, vapor dose is assumed to be the only cause for eye effects; liquid contact with the eyes is neglected. In addition, only vapor dose is assumed to cause respiratory, systemic, and ocular damage; both vapor dose and liquid deposition are assumed to cause skin damage. The following equations were used for the unprotected and protected cases respectively. EDHD w/o protection SK = Dv + DlFf EDHD w/o protection SY,RE,OC = Dv EDHD w/protection SK = D1v + D2v(1 – a) + D1lFf + D2l(1 – a)Ff EDHD w/protection SY, RE, OC = D1v Upon review, it became apparent that the effective dose equations given in Anno, et al. applied to skin exposure only, despite a typographical error stating that the skin effective dose without protection equation given above applied to skin, ocular, and respiratory/systemic effects. Because only vapor exposure results in ocular, systemic, and respiratory effects, the effective dose with protection for ocular and systemic/respiratory effects is due solely to the vapor exposure in the first minute before the mask is donned, as shown above. Ff is the factor used for converting percutaneous HD liquid effects into percutaneous HD vapor effects for use in the DICE algorithm. The ICt50 and ED50 values can be determined from Figures J-5 and J-6, shown below. The following is the calculated value of Ff: Ff = ICt50 (HD/PC/V)/ED50 (HD/PC/L) = 2000/1400 = 1.4 Figure J-5. Inhalation and Ocular Dose response for HD vapor exposure endpoints Figure J-6. Percutaneous Dose response for HD vapor and liquid exposure endpoints In order to make the IDA data from Biostrike usable in the PSR model, the equation above needs to be converted to the Biostrike output format: Without Protection: EDHD w/o protection (SY, RE, OC) = Dav EDHD w/o protection (percutaneous/SK) = Dav + DalFf With Protection: EDHD w/protection (0-1 min, SY, RE, OC) = Dav EDHD w/protection (0-9 min, percutaneous/SK) = Dbv + DblFf This effective dose is used in the DICE algorithms. To calculate performance, a symptom severity category for each system – ocular, respiratory, systemic, and skin – is assigned based on the effective dose. The symptom severity category changes over time as described in Appendix K. These symptom severity categories are used in the calculation of performance as described in Appendix L. APPENDIX K CONSTRUCTION OF EXPOSURE RANGES A Construction of Exposure Ranges for GB To establish the exposure ranges for GB, the 10%, 50% and 90% incidence doses for mild ocular effects, severe inhalation effects, and lethality inhalation were used. These values can be calculated from Figure K-1, shown below. In addition, distinct signs and symptoms, as discussed by Deverill and the ranges normally associated with the symptomatology40 provided the basis for the established exposure ranges. Figure K-1. Inhalation and Ocular Dose response for GB vapor exposure endpoints 40 Deverill, A.P. et al., 1994 Figure K-2 shows the percutaneous effects due to liquid and vapor exposure to GB. As seen on the chart, the exposure values required to produce incidence doses due to percutaneous GB liquid and vapor exposure are significantly higher (approximately ten times) than the incidence doses required to produce effects due to GB inhalation. This difference – and the absence of measurable GB liquid exposures within VLSTRACK – may have contributed to the AMedP-8 working group’s decision to neglect liquid exposure to GB; no specific information, however, is provided as to why this decision was made. Figure K-2. Percutaneous Dose response for GB vapor and liquid exposure endpoints B. Construction of Exposure Ranges for VX Establishing the exposure boundaries for VX could not be based on expected symptomatology due to lack of research. The toxicity mechanism for VX (acetylcholinesterase inhibition) is, however, the same as that resulting from GB exposure. Therefore, the signs and symptoms are expected to be qualitatively the same. In order to establish the VX ranges, VX incidence doses similar to those for GB were used. The incidence exposure values due to inhalation of VX can be determined from Figure K-3; the range boundaries selected for VX yield the same incidence as those initially determined for GB. Table K-1 compares these values and shows the established ranges and injury severity categories for GB and VX due to inhalation effects. Figure K-3. Inhalation and Ocular Dose response for VX vapor exposure endpoints Table K-1: Construction of exposure ranges for VX vapor inhalation injury categories based on comparison with GB vapor inhalation categories. (McClellan, Anno, Matheson, 1998, pg. 9) Injury Category GB Vapor Inhalation Exposure (mg-min/m3) Exposure Boundary Exposure for Effect 0 1 VX Vapor Inhalation Exposure (mg-min/m3) Exposure Boundary 0 No injury 0.25 2 No injury 0.05 ECt10 (ocular) = 0.33 Ect90 ECt90 (ocular) = 0.75 3 ECt10 (ocular) = 0.06 ECt90 (ocular) = 0.14 2 3 same ratio of exposure boundaries as GB 6 4 4 same ratio of exposure boundaries as GB 15 5 10 ECt10 (severe) = 23 30 6 ECt10 (severe) = 17 19 ECt50 (severe) = 35 LCt10 = 45 50 7 ECt50 (severe) = 25 LCt10 = 20 29 ECt90 (severe) = 54 LCt50 = 70 75 8 Exposure for Effect ECt90 (severe) = 37 LCt50 = 30 40 LCt90 = 107 LCt90 = 45 Due to the persistent nature of VX and the lower concentrations required for percutaneous effects due to both liquid and vapor (shown in Figure K-4), VX percutaneous doses were not discounted. In order to determine the dose ranges for percutaneous exposure to VX, a similar table was generated to compare VX exposure ranges resulting in inhalation effects and VX dose ranges resulting from percutaneous liquid exposure. This comparison is shown on Table K-2. VX ocular effects are considered separately from percutaneous effects, and thus, for the lower injury severity category bounds, only similar ratios – as opposed to effects – are considered. Figure K-4. Percutaneous Dose response for VX vapor and liquid exposure endpoints Table K-2: Construction of exposure ranges for percutaneous liquid VX injury categories based on comparison with VX vapor inhalation categories. (McClellan, Anno, Matheson, 1998, pg. 10) VX Vapor Inhalation Exposure (mg-min/m3) Injury Category Exposure Boundary 0 1 Exposure for Effect 2 No injury ECt10 (ocular) = 0.06 ECt90 (ocular) = 0.14 3 same ratio of exposure boundaries 0.4 same ratio of exposure boundaries as GB 4 4 same ratio of exposure boundaries 0.8 same ratio of exposure boundaries as GB 10 5 same ratio of exposure boundaries 2 ECt10 (severe) = 17 19 6 ED10 (severe) = 2.8 4 ECt50 (severe) = 25 LCt10 = 20 29 7 Dose for Effect 0.01 2 ED50 (severe) = 5 LD10 = 6 8 ECt90 (severe) = 37 LCt50 = 30 40 41 Dose41 Boundary 0 No injury 0.05 8 VX Liquid Percutaneous Exposure (mg/70 kg man) ED90 (severe) = 9 LD50 = 10 12 LCt90 = 107 LCt90 = 16 These dose boundaries are also applicable to deposition in mg/m2 under the assumption of an effective exposed skin area of 1 m2/person. APPENDIX L PERFORMANCE FACTOR MEASURES A. Definitions and Variables S/S signs and symptoms t0 the normative task performance time when in a normal healthy state t time required to perform the task when a state of illness prevails (Note: t is always greater than t0) qualitative performance, expressed by the ratio t0/t p B. tijk the estimated task time for the jth task provided by the ith respondent covering the kth S/S complex ′ vector of estimated regression coefficients – provides the weighting of the severity of each different physical system on performance x′k vector of integers describing the symptom severity of each different physical system P̂k expected value of task performance (post application of a smoothing function) P1 expected performance when all symptom severity category values are one – individual is in good health (pre application of a smoothing function) Pm highest possible performance when a single symptom severity category is greater than one P the difference between one and P1 performance smoothing function correction factor applied to performance smoothing function equal to 0.01. Agent Symptomatology The first step in determining the impacts of chemical agent exposure on performance was to classify the signs and symptoms (S/S) for each agent and determine, given some initial dose, at what time which symptoms could be expected. S/S tables were generated for GB and HD. For GB six systems were modeled – upper gastrointestinal, lower gastrointestinal, muscular, ocular, respiratory, and mental; four systems were used for HD – skin, systemic, respiratory, and ocular. The impact of each agent on the specified systems was categorized in terms of the amount and type of resultant distress using five levels of severity, ranging from one (lowest) to five (most severe). These symptomatology tables are shown below (Table L-1, GB, and Table L-2, HD); a specific table was not created for VX. Because of the identical toxicity mechanisms for GB and VX, the S/Ss could be expected to be qualitatively the same. Using these symptomatology levels, a general time- and dose-relationship table was established for both GB and HD, following the Defense Nuclear Agency/Intermediate Dose Program (DNA/IDP) methodology1. These tables are shown as Figures L-1 and L-2. The order of the digits in each of the blocks in Figures L-1 and L-2 corresponds to the order of the severity categories as listed in the S/S tables. Using agent ranges of interest, the S/S for GB and HD were used to estimate the impact of these agents on performance of crewmembers performing close combat light (CCL) infantry and artillery tasks. A questionnaire was generated, listing specific and general CCL tasks, along with a set of symptoms corresponding to a particular S/S set. The M119A Light Howitzer was selected as representative of CCL tasks, and subject matter experts (SME) were surveyed, using the questionnaires, to determine how different symptoms affected their ability to perform combat-related tasks. For the series of tasks and a set of symptoms (as listed on the S/S tables), the SMEs were asked to evaluate how long the tasks would take and their level of confidence in their own responses. The performance data gathered from the questionnaires was averaged over the respondents, in order to prepare it for the regression analysis.2 Of note, graphical and typographical inaccuracies were noted in the original DICE sign/symptom severity data for HD. In addition, in 1997, further research was completed by Dr. Millard M. Mershon on the ocular effects post-exposure to HD. These corrections and updates were incorporated into the final algorithms and the final DICE calculation models. In McClellan, et. al, these changes are included as four graphical representations of the sign/symptom severity for each affected system. An updated sign/symptom complex chart including these changes is included as Table L-3. 1 McClellan, Gene E. et al., 1998. NOTE: Tables L-1 and L-2 and Figures L-1 and L-2 also from McClellan, et al. 2 Anno, G.H., D. B. Wilson, and M. A. Dore, 1984. Table L-1. GB signs and symptoms (Textual Descriptions for Questionnaires) UG: Upper Gastrointestinal Distress 1 No effect 2 Burning feeling above the stomach 3 Nauseated, mouth waters, sweating 4 Vomited once or twice, nauseated and may vomit again 5 Vomited several times, including dry heaves LG: Lower Gastrointestinal Distress 1 No effect 2 Abdominal pain 3 Abdominal cramps, with diarrhea once or twice 4 Frequent diarrhea, with awful gut cramps 5 Uncontrollable diarrhea and urination MU: Muscular Distress 1 No effect 2 Muscles twitch, feeling somewhat tired and weak 3 Muscles tremble, uncoordinated, feeling tired and weak 4 Whole body trembles with sporadic convulsions 5 Paralyzed OC: Ocular Distress 1 No effect 2 Vision is slightly blurred and dim 3 Vision is blurred and dim, and pressure is felt behind the eyes 4 Light hurts eyes, headache, with very blurred and dim vision 5 Extreme headache and temporary blindness RE: Respiratory Distress 1 No effect 2 Tight chest, coughing, and runny nose 3 Difficult to breathe, wheezing breath, respiratory congestion 4 Breathing sporadically stops and starts, skin has a purple or blue color 5 Breathing stops completely ME: Mental Distress 1 No effect 2 Anxious and irritable 3 Hard to remember or concentrate 4 Cannot remember or concentrate 5 Unconscious Figure L-1. Sign/symptom complexes for wet skin exposure to GB (nerve gas – Sarin) Table L-2. HD signs and symptoms (Textual Descriptions for Questionnaires) SK: Skin Damage 1 2 3 4 5 No effect Skin sensitive to touch in crotch, armpits, and on inside of elbow and knee joints Skin sore in crotch, armpits, elbow and knee joints, and painful when moving, red swollen skin, tiny blisters on hands and neck Skin raw and painful in crotch, armpits, elbow and knee joints, red swollen body skin, large blisters on hands and neck Skin peels off leaving open raw areas and painful blisters SY: Systemic Damage 1 2 3 4 5 No effect Nauseated and swallows often Headache, nauseated, vomited once or twice Headache and fever, vomited several times and will again Pounding headache, dry heaves, fatigued from vomiting RE: Respiratory Damage 1 2 3 4 5 No effect Dry mouth, dry cough, sneezing, and runny nose Sore throat, continuous coughing, hoarse voice, chest feels tight Hurts to breathe, hacking cough, cannot speak Awful check pain, wheezing and short of breath, coughs up red-colored mucus OC: Ocular Damage 1 No effect 2 Eye sting and tear 3 Eyes feel gritty and sensitive to light, nonstop tears flood eyes 4 Eyelids puffy and eyes burn, painful to keep open 5 Eyelids swollen shut and burning eyes too painful to open Figure L-2. Sign/symptom complexes for wet skin exposure to HD (mustard gas) 1 1112 10 1213 1214 1312 3333 3121 1121 2121 3343 3131 2111 Time (hr) 100 Figure L-3. Sign/symptom complexes for wet skin exposure to HD (mustard gas) – updated to reflect DICE corrections and additional research 1121 1231 3323 2232 1232 3344 3122 3132 3345 3435 3525 3424 3414 2111 2121 3124 3235 3325 3225 2324 3324 2213 2112 2313 2312 1312 3335 100 3123 2122 2123 2112 2223 1113 2224 1213 1212 1211 1212 1112 1112 Dose (mg-min/m3) 1231 1131 1121 1131 1121 2232 1232 4343 1231 2232 1232 4343 5353 5354 4354 4353 5455 5355 5345 5445 5535 5525 5425 5424 5313 1312 4455 4355 4345 4445 3535 3525 3424 2323 2313 1312 1000 10 1000 100 C. Performance Measures The measure of performance for military combat tasks will be considered as a function of time; although performance is usually a function of both time and accuracy, it was determined that evaluating accuracy reductions as a result of chemical exposures was extremely difficult for the SMEs. This was partially due to the tendency of SMEs to regards tasks as either “complete” or “incomplete” without regard to the accuracy or delays that might result from attempts to maintain accuracy. Thus, performance (p) can be regarded as the time ratio of normative task performance time when in a healthy state (t0) to the time required to perform the task when in a state of illness as described by a set of symptoms (t). p = t0/t When in good health then, p = 1, and if the task cannot be performed, p = 0. In order to determine the average performance over N number of respondents, a new time variable (tijk) was introduced – the time estimated for the jth task provided by the ith respondent considering the kth S/S complex. Using this definition, the average performance for the jth task given the kth S/S complex is: 1 N Pjk t 0 j / t ijk N i 1 D. (0 Pjk 1) Performance Function Multivariate regression analyses were used to derive the task performance functions. A logistic transformation was used to predict performance values and ensure that those values lie within the expected interval (0 to 1). The primary assumption of the logistic model is that the performance can be expressed as some function of a linear combination of the factor (symptom severity) variables – there are six corresponding variables to describe each time/dose GB relationship and four corresponding variables to describe the HD time/dose relationships. Using the performance factor designated above – an averaged estimate of performance for the jth task and the kth S/S complex – the logistic regression model may be represented by: Pjk n 1 P x'k + k , (1 k K) jk The x'k vector represents integers for denoting symptom severity level for the kth symptom severity level and the lth symptom category. ' is a vector of regression coefficients that are estimated. Both vector sets contain an additional component corresponding to the intercept. Thus, there are seven coefficients for GB and five for HD. The next step is to determine a means for predicting performance values for any S/S complex, xk. Beginning with the equation above: Pjk n 1 P x'k + k , (1 k K) jk Pjk 1 P jk e x 'k k , (1 k K) 1 Pjk , (1 k K) x 'k k Pjk e x 'k k Pjk 1 e e x 'k k , (1 k K) x ' k k Pjk e 1 e x 'k k , (1 k K) Pjk 1 e x' k k 1 , (1 k K) Finally, the inverse transformation of the logistic regression can be applied to yield the performance function for predicting expected values of task performance for any S/S complex, given as: Pˆ k 1 x' k ̂ e 1 , (1 k K) The performance measure of a particular crewmember is based on a composite of two or more separate tasks. The beta coefficients and statistical parameters resulting from the regression analysis are compiled in Tables L-3 and L-4 for GB and HD respectively. Table L-3. Performance regression summary for GB: No. 1 cannoneer (loader) (from McClellan, et al.) Degrees of freedom: F(6, 23): Prob > F: R-square: Adj R-square: Root MSE: Symptom Coefficient Standard Error 23 61.2900 <.0005 .9411 .9258 .24715 t P > |t| 95% Confidence Interval Intercept 5.675684 .354942 15.990 <.0005 4.9414300 6.4099370 Upper Gastro -.501250 .041804 -11.990 <.0005 -.5877290 -.4147716 Lower Gastro -.626904 .062884 -9.969 <.0005 -.7569887 -.4968186 Muscular -.978815 .065066 -15.043 <.0005 -1.1134140 -.8442152 Ocular -.822573 .097043 -8.476 <.0005 -1.0233220 -.6218234 Respiratory -.657991 .059124 -11.129 <.0005 -.7802975 -.5356843 Mental -.556144 .067417 -8.249 <.0005 -.6956061 -.4166821 Table L-4. Performance regression summary for HD: No. 1 cannoneer (loader) (from McClellan, et al.) Degrees of freedom: F(4, 25): Prob > F: R-square: Adj R-square: Root MSE: Symptom Coefficient Standard Error 25 18.5200 <.00005 .7477 .7073 .71362 t P > |t| 95% Confidence Interval Intercept 6.647001 .929549 7.151 <.0005 4.7325590 8.5614430 -1.425135 .166689 -8.550 <.0005 -1.7684380 1.0818330 Systemic -.786148 .166325 -4.727 <.0005 -1.1287010 -.4435950 Respiratory -.625109 .160978 -3.883 <.0005 -.9566491 -.2935684 Ocular -.900659 .268601 -3.353 .003 -1.4538520 -.3474651 Skin Damage E. Performance-Based Casualty Calculations Performance can be calculated utilizing the equations determined above, however, performance when all of the sign/symptom severity factors are at their lowest – all equal one – does not result in a P̂k =1. A smoothing factor is applied to force P̂k =1; this impacts only the performance at the lowest sign/symptom severities (highest performance) while not affecting lower performance values. The final equation for calculating performance is: *P1 Pˆk Pˆ 'k Pˆk P * e , (1 k K) ( P1 Pm ) 1 * n(P / ) and where P 1 P1 where P̂ ′k is the smoothed performance. The calculation and derivation of the variables used in the performance function for GB and HD are included in their entirety as Tables L-5 and L-6 respectively. Although time is not an explicit variable in the above equation, performance does change with time as a function of the sign/symptom severities. In the hours, days, and weeks following agent exposure, some signs/symptoms improve while others worsen (as shown in the sign/symptom severity profiles), resulting in performance changes over time. Figure L-4 shows how performance capabilities change over time for a loader for a set of several different initial exposures between ten and one thousand mg-min/m3. Performance, therefore, needs to be calculated at several different time periods to obtain a useful picture of decreased performance, Physically Demanding Performance casualties, fatalities, and returns to duty. Loader, HD Vapor 100% 10 75% 15 25 Performance 50 70 100 50% 125 150 250 500 1000 125 Est 25% 100 Est 0% 0 2 4 6 8 10 12 14 16 18 20 22 24 26 Time (hrs) Figure L-4. Loader Performance Capability Changes over Time for HD Vapor Exposures (in mg-min/m3) Table L-5. Performance Function Calculation for GB Smoothed Performance Function Step 1: Step 2: Step 3: Identify Constants and Equations B0 = 5.675684 intercept B1 = -0.50125 upper GI B2 = -0.626904 lower GI B3 = -0.978815 muscular B4 = -0.822573 ocular B5 = -0.657991 respiratory B6 = -0.556144 mental = 0.01 correction factor Determine Pm, the highest possible performance when a single sign/symptom severity category is greater than one Pm = Pk(1,2,1,1,1,1,1) Pm = (1 + exp(-x0*B0 + -x1*B1 + -x2*B2 + -x3*B3 + -x4*B4 + -x5*B5 + -x6*B6))^-1 x0 x1 x2 x3 x4 x5 x'k(1,2,1,1,1,1,1) = 1 2 1 1 1 1 x'k*B' = 5.675684 -1.0025 -0.626904 -0.978815 -0.822573 -0.657991 Pk(1,2,1,1,1,1,1) = 0.737063 x'k(1,1,2,1,1,1,1) = 1 1 2 1 1 1 x'k*B' = 5.675684 -0.50125 -1.253808 -0.978815 -0.822573 -0.657991 Pk(1,1,2,1,1,1,1) = 0.711997 x'k(1,1,1,2,1,1,1) = 1 1 1 2 1 1 x'k*B' = 5.675684 -0.50125 -0.626904 -1.95763 -0.822573 -0.657991 Pk(1,1,1,2,1,1,1) = 0.634876 x'k(1,1,1,1,2,1,1) = 1 1 1 1 2 1 x'k*B' = 5.675684 -0.50125 -0.626904 -0.978815 -1.645146 -0.657991 Pk(1,1,1,1,2,1,1) = 0.670276 x'k(1,1,1,1,1,2,1) = 1 1 1 1 1 2 x'k*B' = 5.675684 -0.50125 -0.626904 -0.978815 -0.822573 -1.315982 Pk(1,1,1,1,1,2,1) = 0.705581 x'k(1,1,1,1,1,1,2) = 1 1 1 1 1 1 x'k*B' = 5.675684 -0.50125 -0.626904 -0.978815 -0.822573 -0.657991 Pk(1,1,1,1,1,1,2) = 0.726287 Pk(1,2,1,1,1,1,1) = 0.737063 Calculate Smoothing Factor P = 1 - P1 0.1777 Step 5: (1 + exp(-x'k*B))^-1 1 - P1 (P1 - Pm)^-1*ln(P/) Pk + P*e(-*(P1-Pk)) Calculate Unsmoothed Performance at P1 = Pk(1,1,1,1,1) P1 = Pk(1,1,1,1,1,1,1) P1 = (1 + exp(-x0*B0 + -x1*B1 + -x2*B2 + -x3*B3 + -x4*B4 + -x5*B5 + -x6*B6))^-1 x0 = 1 x0*B0 = 5.675684 x1 = 1 x1*B1 = -0.50125 x4 = 1 x4*B4 = x2 = 1 x2*B2 = -0.626904 x5 = 1 x5*B5 = x3 = 1 x3*B3 = -0.978815 x6 = 1 x6*B6 = P1 = 0.8223 Pm = Step 4: Pk = P = P'k = (P1 - Pm)^-1*ln(P/) 15.35296 Calculate P'k, Smoothed Performance Pk + P*e(-*(P1-Pk)) P'k = P'k(1,1,1,1,1,1,1)= 1 -0.822573 -0.657991 -0.556144 x6 1 -0.556144 1 -0.556144 1 -0.556144 1 -0.556144 1 -0.556144 2 -1.112288 Table L-6. Performance Function Calculation for HD Smoothed Performance Function Step 1: Identify Constants and Equations B0 = 6.647001 intercept B1 = -1.425135 skin B2 = -0.786148 systemic B3 = -0.625109 respiratory B4 = -0.900659 ocular = 0.01 correction factor Pk = P = P'k = (1 + exp(-x'k*B))^-1 1 - P1 (P1 - Pm)^-1*ln(P/) Pk + P*e(-*(P1-Pk)) Step 2: Calculate Unsmoothed Performance at P1 = Pk(1,1,1,1,1) P1 = Pk(1,1,1,1,1) P1 = (1 + exp(-x0*B0 + -x1*B1 + -x2*B2 + -x3*B3 + -x4*B4))^-1 x0 = 1 x0*B0 = 6.647001 x1 = 1 x1*B1 = -1.425135 x2 = 1 x2*B2 = -0.786148 x3 = 1 x3*B3 = -0.625109 x4 = 1 x4*B4 = -0.900659 P1 = 0.948336 Step 3: Determine Pm, the highest possible performance when a single sign/symptom severity category is greater than one Pm = Pk(1,1,1,2,1) Pm = (1 + exp(-x0*B0 + -x1*B1 + -x2*B2 + -x3*B3 + -x4*B4))^-1 x0 x1 x2 x3 x4 x'k(1,2,1,1,1) = 1 2 1 1 1 x'k*B' = 6.647001 -2.85027 -0.786148 -0.625109 -0.900659 Pk(1,2,1,1,1) = 0.815299 x'k(1,1,2,1,1) = 1 1 2 1 1 x'k*B' = 6.647001 -1.425135 -1.572296 -0.625109 -0.900659 Pk(1,1,2,1,1) = 0.893195 x'k(1,1,1,2,1) = 1 1 1 2 1 x'k*B' = 6.647001 -1.425135 -0.786148 -1.250218 -0.900659 Pk(1,1,1,2,1) = 0.907614 x'k(1,1,1,1,2) = 1 1 1 1 2 x'k*B' = 6.647001 -1.425135 -0.786148 -0.625109 -1.801318 Pk(1,1,1,1,2) = 0.881769 Pm = Step 4: 0.907614 Calculate Smoothing Factor P = 1 - P1 0.051664 Step 5: Pk(1,1,1,2,1) = (P1 - Pm)^-1*ln(P/) 40.32611 Calculate P'k, Smoothed Performance Pk + P*e(-*(P1-Pk)) P'k = P'k(1,1,1,1,1) = 1 F. AMedP-8 Chemical Table Generation There are two types of categories for exposed personnel, as represented by the tables in Sections 4 through 10 of the AMedP-8 Chemical Manual; one presents typical injuries sustained by personnel exposed to various chemical exposure levels, while the other indicates post-attack performance capability. A person becomes a casualty when their performance decreases to 25% or lower. An injury category is assigned when the person becomes a casualty. For GB and VX, the typical injuries by category are determined by taking the initial effective exposure and entering it into the Injury Severity Category tables (shown in Section Four). For HD, determining the injury category is a two step process. First, when the individual becomes a casualty, they are classified as some combination of injury severity categories – i.e., Eye-Respiratory-Skin, Eye-Skin, or Respiratory only – on the basis of their sign/symptom severity in each category. An eye or skin injury category is assigned when the associated sign/symptom severity category is greater than or equal to two. A respiratory injury category is assigned when either the respiratory or systemic sign/symptom severities are greater than or equal to two. Once assigned, the individual remains in the prescribed injury severity category until they become a fatality (performance decreases to less than .0001 for GB and VX, .000023 for HD) or return to duty (performance increases to greater than 75%). Additionally, in the Personnel by Injury Category Table, individuals are assigned a numerical injury category. This category is determined by using the vapor (for ocular and respiratory/systemic) and effective (for skin) exposures and determining the applicable injury severity number for each system. Thus, for example, an individual with a vapor exposure of 25 mg-min/m3 and an effective exposure of 90 mg-min/m3, will have a final injury severity code of 2-1-2. It may be important to note that although injury severity category six is the highest category given for eye effects due to HD exposure, category five is the highest category assigned in the tables given in Appendices 4-10 of AMED P-8 Chemical. Calculations to produce appendices A-F for this document indicate that approximately fifty attacks resulted in ocular HD injury severity category six. To determine performance bands, casualty status, and fatalities, the performance equation described above was used. For all three agents – GB, VX, and HD – performance was calculated at ten different time periods – 3 hours, 1-7 days, 15 days, and 30 days. If at any time during those periods performance dropped to 25% or lower, the individual became a casualty and a casualty flag was assigned; similarly, if performance dropped below the prescribed fatality threshold, the individual became a fatality. One additional note is important. When calculating performance on the edges of the injury category ranges (exposures of 25, 50, 70, 100, etc. measured in mg-min/m3), the sign/symptom severity for both the upper and lower category were averaged to determine the sign/symptom severity at that time period. For example, at three hours, the sign/symptom severity for range 50-70mg-min/m3 is 1 and the sign/symptom severity range for 70-100 mgmin/m3 is 2, therefore, when modeled during the generation of AMedP-8 Chemical, the two sign/symptom severities were averaged and a severity of 1.5 was used to determine performance at three hours for 70 mg-min/m3. APPENDIX M REFERENCES Anno, G.H., Wilson, D.H., and Dore, M.A. Nuclear Weapons Effects Research at PSR, 1983: Acute Radiation Effects on Individual Crewmember Performance. Defense Nuclear Agency, Alexandria, VA, DNA-TR-85-52, August 1984. Anno, G. G., et al. Predicted Performance on Infantry and Artillery Personnel Following Acute Radiation or Chemical Agent Exposure. DNA-TR-93-174, Defense Nuclear Agency, Washington DC, November 1994. Bauer, Timothy J. and Roger L. Gibbs. Software User’s Manual for the Chemical/Biological Agent Vapor, Liquid, and Solid Tracking (VLSTRACK) Computer Model, Version 1.6.1 (DOSPC), NSWCDD/MP-95/197, Naval Surface Warfare Center. Dahlgren, Virginia, October 1995. Deverill, A.P. et al. Defense Nuclear Agency Improved Casualty Estimation (DICE): Clinical Insult Program and Acute Chemical Agent Exposure Effects, DNA-TR-93-162, Defense Nuclear Agency, Washington DC, May 1994. Flythe, Mary Catherine. BioStrike-3 User’s Manual. Institute for Defense Analyses, September 2000. Glickman, Todd S. “Surface tension.” Glossary of Meteorology. (American Meteorological Society: Cambridge, Massachusetts, June 2000) amsglossary.allenpress.com/glossary/browse (accessed July 10, 2005). McClellan, G. E., et al. Consequence Analytic Tools for NBC Operations, Volume 3: Chemical Agent Exposure and Casualty Estimation, DSWA-TR-97-61-V3, Defense Special Weapons Agency, Alexandria, Virginia, September 1988. STANAG 2475 NBC/MED, Planning Guide for the Estimation of NBC Battle Casualties (Nuclear), AMedP-8(A), Volume I STANAG 2476 NBC/MED, Planning Guide for the Estimation of NBC Battle Casualties (Biological), AMedP-8(A), Volume II STANAG 2477 NBC/MED, Planning Guide for the Estimation of NBC Battle Casualties (Chemical), AMedP-8(A), Volume III