Ingredients in the Skinny Fiber Weight Loss Supplement
There are only 3 main ingredients in the Skinny Fiber Weight Loss Supplement: Glucomannan,
Caralluma and Cha De Bugre. There are also very helpful enzymes added to our product: Lipase
and Protease.
Glucomannan is a sugar made from the root of the konjac plant (Amorphophallus konjac).
Glucommanan powder, capsules, and tablets are used as medicine.
Glucomannan is used for constipation, weight loss in adults and children, type 2 diabetes, blood sugar
control, and lowering cholesterol. In foods, Glucomannan is used as a thickener or gelling agent.
Glucommanan flour and powder are used in food.
How does it work? Glucomannan might work in the stomach and intestines by absorbing water to form
a bulky fiber which treats constipation. It may also slow the absorption of sugar and cholesterol from
the gut, helping to control sugar levels in diabetes, and reducing cholesterol levels.




Constipation.
Weight loss.
High cholesterol when used with chitosan.
Other conditions.


Reducing cholesterol levels in people with diabetes.
Helping control blood sugar in people with type 2 diabetes.
Glucomannan powder or flour in enriched foods such as Japanese noodles is SAFE.
Glucomannan powder and capsules are SAFE for most adults and children.
[Chronic use of Glucomannan in the dietary treatment of severe obesity]
Vita PM, Restelli A, Caspani P, Klinger R.
Centro per la Farmacoterapia delle Malattie Nutrizionali, Universita degli Studi di Milano.
Two groups of 25 severely obese patients underwent 3 months of hypocaloric diet therapy either alone
or associated with a Glucomannan-based fibrous diet supplement (approx. 4 g/die in 3 doses). The
comparative analysis of the results obtained in both groups showed that the diet + Glucomannan group
had a more significant weight loss in relation to the fatty mass alone, an overall improvement in lipid
status and carbohydrate tolerance and a greater adherence to the diet in the absence of any relevant side
effects. Due to the marked ability to satiate patients and the positive metabolic effects, Glucomannan
diet supplements have been found to be particularly efficacious and well tolerated even in the longterm treatment of severe obesity.
[Evaluation of the action of Glucomannan on metabolic parameters and on the sensation of
satiation in overweight and obese patients] Cairella M, Marchini G.
Servizio Speciale di Dietologia, Policlinico Umberto I, Universita La Sapienza Roma.
The authors studied the behavior of body weight, blood glucose, total serum cholesterol, and hunger
and satiety sensation in 30 patients treated for 60 days with a 1.200 kcal (5040 kj) diet plus either
placebo or Glucomannan. All the variables considered show that the low-calorie diet plus
Glucomannan is more effective than the low-calorie diet alone.
Caralluma fimbriata is a succulent plant, in the cactus family, that has been used as a natural appetite
suppressant in India for centuries. It's a new arrival in the family of cacti and succulent plants that are
becoming increasingly popular for their appetite suppressant, and weight loss properties, as well as
their ability to lower blood sugar. Supplements made from the popular hoodia gordonii cactus from the
Kalahari Desert in Africa, are, for example, growing in popularity and usage in the U.S. and Europe.
Like hoodia, Caralluma fimbriata has been used to suppress appetite, and as a portable food for
hunting. It is used to suppress hunger and appetite, and enhance endurance throughout India. It is also
sometimes considered a "famine food," used during periods of famine to suppress appetite. For
centuries, people in rural areas of India have eaten Caralluma fimbriata, which grows wild over various
parts of the country.
Caralluma fimbriata is believed to block the activity of several enzymes, which then blocks the
formation of fat, forcing fat reserves to be burned. Caralluma fimbriata is also believed to have an
effect on the appetite control mechanism of the brain.
Ayurvedic (traditional Indian medicine) experts have noted that there are no adverse effects when
using Caralluma fimbriata, and the plant has no known toxicity.
CARALLUMA FIMBRIATA CLINICAL TRIAL
Use of Caralluma Fimbriata extract to Reduce Weight
A double-blind, placebo-controlled, randomized clinical trial on Caralluma fimbriata extract was done
on 50 human subjects. This study consisted of 50 obese patients, 25 on the active compound and 25 on
placebo. The trial lasted for eight weeks.
Subjects were tested for changes in key indicators of weight-loss, including anthropometry , body fat
composition, BMI, net weight and systemic functions.
The following key observations were made in this trial:



Statistically significant reductions were recorded in all key indicators of weight loss
Caralluma fimbriata was well tolerated
Caralluma fimbriata extract showed minimal adverse effects which were gastrointestinal and
transient in nature
Mode of action Caralluma fimbriata contains pregnane glycosides which are believed to block the
activity of citrate lyase. By blocking this enzyme, Caralluma fimbriata blocks the formation of fat by
the fat loss by the body.
Appetite Suppression Further,Caralluma fimbriata also blocks another enzyme called Malonyl
Coenzyme A. By blocking this enzyme, fat formation is further blocked and the body is forced to burn
its fat reserves. This accelerates the rate of fat loss by the body.
Caralluma fimbriata has been clinically demonstrated to suppress appetite and stop hunger pangs in
patients. It is believed that the pregnane glycosides in Caralluma fimbriata inhibit the hunger sensory
mechanism of the hypothalamus. http://www.caralluma.tv/clinical-trial1.php
Cha de Bugre is a Brazilian tree. The fruit and leaves are used to make tea and medicine.
Cha de Bugre is a small tree that grows twelve to sixteen inches. It is indigenous to Brazil, and is found
mostly in the Brazilian States of Goais, Acre and Bahia. Brazilians often call Cha de Bugre, Café de
Mato, as it produces a real fruit similar to a coffee bean that can be roasted and used as a coffee
substitute. In Brazil, Cha de Bugre is drunk as a coffee or as a tea. It is said to have both weight loss
and appetite reducing effects.
Cha de Bugre is becoming a common ingredient in weight loss products and supplements. Due to the
stimulant properties of Cha de Bugre, many manufacturers have realized that it has the potential to be
an ideal replacement for the now banned Ephedra. In the ingredient listings of many weight loss
products, you will often see Cha de Bugre listed as an ingredient, paired with Hoodia Gordonii.
Manufacturers of weight loss products will often include Cha de Bugre and Hoodia Gordonii together,
as they claim that the Cha de Bugre increases the potency of the Hoodia Gordonii. There are a number
of testimonials online written by people who have used products containing Cha de Bugre. These
testimonials are mixed, and it seems that a number of people have found the product helpful, whilst
others have complained of side effects such as dry mouth, anxiety and insomnia.



Weight loss products containing Cha de Bugre can be ordered on line.
Cha de Bugre is said to have appetite suppressing and diuretic properties.
There are testimonials available online for products containing Cha de Bugre.
Health benefits of Chá de Bugre
Cha De Bugre has been used for centuries by the indigenous population of Brazil. The allantoin and
allantoic acid in Chá de Bugre may explain its traditional use in the promotion of wound healing. It is
also used in Brazil and Haiti as a tea to help relieve coughs and asthma. Cha de Bugre is also believed
to help in the regulation of renal function, and the reduction of uric acid.
In 1990 research at a Japanese University revealed that Chá de Bugre leaf extract reduced herpes virus
penetration by 99% when cells grown in vitro were pre-treated with the extract. In 1994, utilizing an
extract of the branches and leaves, it was shown that the Herpes virus yield was reduced by 33% with
as little as 0.25 mcg/ml of Chá de Bugre. It was also demonstrated that Cha de Bugre extract had toxic
activity against cancer cells in vitro (demonstrating a 40% inhibition). In 1997, research with rabbits
and guinea pigs validated the traditional use of Chá de Bugre as a heart tonic.
http://practicalweightloss.org/cha-de-bugre-and-weight-loss/
The Enzymes:
Lipase
Lipase is a water-soluble enzyme used in breaking down lipids, commonly called fats. In humans,
lipase is mainly produced in the pancreas, and facilitates the absorption of fats by the intestines. This
enzyme is also found in most living organisms, including plants, animals, bacteria and yeast. Lipase
has a significant number of uses, both physiologically and industrially.
Physiological Uses of Lipase
Lipase plays a very important role in the way living things, especially humans, function. While it is a
fact that too much fat is not healthy, fats are highly necessary in the human body. Vital structures, like
cell membranes, are made up of fats. It is, therefore, essential that the body is able to absorb fats from
food, in order to keep these structures healthy. All nutrients transported via the bloodstream (a liquid
medium) must be soluble. Lipase breaks down lipids, by hydrolysis (water-splitting), into fatty acids
and glycerol, converting the insoluble fats into soluble form, so that they can be properly digested and
assimilated. Lipase is especially important to babies, whose only food is milk (a lipid-rich food) that
needs to be properly digested. http://www.lipase.net/
Proteases in Enzyme Therapy
Protease refers to a group of enzymes whose catalytic function is to hydrolyze (breakdown) peptide
bonds of proteins. They are also called proteolytic enzymes or proteinases. Proteases differ in their
ability to hydrolyze various peptide bonds. Each type of protease has a specific kind of peptide bonds it
breaks. Examples of proteases include: fungal protease, pepsin, trypsin, chymotrypsin, papain,
bromelain, and subtilisin.
Proteolytic enzymes are very important in digestion as they breakdown the protein foods to liberate the
amino acids needed by the body. Additionally, proteolytic enzymes have been used for a long time in
various forms of therapy. Their use in medicine is gaining more and more attention as several clinical
studies are indicating their benefits in oncology, inflammatory conditions, blood rheology control, and
immune regulation.
Contrary to old beliefs several studies have shown that orally ingested enzymes can bypass the
conditions of the GI tract and be absorbed into the blood stream while still maintaining their enzymatic
activity. Commercially, proteases are produced in highly controlled aseptic conditions for food
supplementation and systemic enzyme therapy. The organisms most often used are Aspergillus niger
and oryzae.
Proteases as Scavengers of Oxidized and Damaged Proteins
Oxidative reactions generate free radical damage to various molecules including proteins. Free radicals
have been implicated in accelerating the aging process as well as several diseases, including diabetes,
atherosclerosis, and neurodegenerative conditions. Under proper conditions of nutrition and adequate
activity of antioxidant enzymes, the free radical damage is minimized. However, in many instances,
the body is overwhelmed by the load of proóoxidants (free radical generating molecules), resulting in
oxidative stress.
One consequence of oxidative stress is the formation of oxidized proteins. Oxidized proteins often
loose their function (become inactive), and undergo unfolding or conformational change of their
structure which enhances their susceptibility to proteolysis. For instance, oxidized proteins in blood or
extra cellular fluid, include hormones, immune system proteins, transport proteins, and other proteins
needed at various cellular locations.
As these oxidized proteins lose their biological function, they may not carry out the cellular tasks and
biochemical reactions they are meant to perform For instance, an oxidized hormone may not be able to
attach to its receptor on the cell surface; an oxidized enzyme may not perform its activity; an oxidized
antibody molecule will not bind adequately to its antigen.
Oxidative reactions occur in a cascade manner. Therefore, oxidation of one protein may lead to further
oxidation reactions within the same molecule and/or other molecules which amplify the damaging
effect. The oxidation of a protein, if not corrected, may result in impairment of biochemical functions
of vital importance to the cellular viability. In order to avoid the cascade effect, oxidized proteins may
be reduced by an antioxidant enzyme or vitamin to their normal (native) form, or removed by
proteolysis.
Oral proteases taken on an empty stomach have been shown to be absorbed and carried into the blood
stream where they are bound to Alpha2-macroglobulin. The binding of the Alpha2-macroglobulin to
proteases does not inactivate the proteolytic activity of the protease. However, the complexing of the
Alpha2-macroglobulin ensures the clearance of the protease from the organism. Several studies have
indicated that oral proteases bound to the macroglobulins hydrolyze immune complexes, proteinaceous
debris, damaged proteins, and acute phase plasma proteins in the blood stream' It is suggested that oral
proteases may help hydrolyze and remove extra cellular proteins damaged by free radicals, which are
especially susceptible to proteolysis, as mentioned above.
http://www.enzymeessentials.com/HTML/proteases.html
This is one of the best and most effective supplements for losing weight, burning stored fat in the body,
digestion, stabilizing blood sugar levels and a host of other health benefits!
Skinny Fiber Works!