September 2015 Curriculum Vitae KENNETH J. OESTREICH, Ph.D. Contact Information Address: Virginia Tech Carilion Research Institute and School of Medicine 2 Riverside Circle Roanoke, VA 24016 E-mail: oestrk@vtc.vt.edu Telephone: (540) 526-2208 Fax: (540) 985-3373 Appointments 2013-Present 2013-Present 2014-Present 2014-Present Assistant Professor Virginia Tech Carilion Research Institute (VTCRI), Roanoke, VA Assistant Professor Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine (VMRCVM) Virginia Tech, Blacksburg, VA Assistant Professor Virginia Tech Carilion School of Medicine (VTCSOM), Roanoke, VA Assistant Professor Faculty of Health Sciences, Virginia Tech, Blacksburg, VA Education and Training 2008-2013 Senior Postdoctoral Fellow University of Washington, Seattle, WA Mentor: Dr. Amy S. Weinmann 2006-2008 Postdoctoral Fellow Emory University, Atlanta, GA Mentor: Dr. Jeremy M. Boss 2006 Ph.D. - Microbiology and Immunology Vanderbilt University, Nashville, TN Advisor: Dr. Eugene M. Oltz 2000 Bachelor of Science, Chemistry College of Arts and Sciences Tennessee Tech University, Cookeville, TN Publications Peer-reviewed Publications 1. Oestreich, K.J.*, K.A. Read, S.E. Gilbertson, K.P. Hough, P.W. McDonald, V. Krishnamoorthy, and A.S. Weinmann*. Bcl-6 directly represses the glycolysis pathway gene program. Nat. Immunol. 15: 957-964, 2014. PMCID: In process. *Co-Corresponding authorship Featured in “News and Views”: Man, K. and Kallies, A. Bcl-6 gets T cells off the sugar. Nat. Immunol. 15: 904-905, 2014. Featured in “Nature Reviews Immunology”: Leavy, O. BCL-6 curbs glycolysis. Nat. Rev. Immunol. 14: 650-651, 2014. 2. Oestreich, K.J., S.E. Mohn, and A.S. Weinmann. Molecular mechanisms that control the expression and activity of Bcl-6 in Th1 cells to regulate flexibility with a Tfh-like gene profile. Nat. Immunol. 13: 405-11, 2012. PMCID: PMC3561768. 3. Youngblood, B*, K.J. Oestreich*, S.J. Ha, J. Duraiswamy, R.S. Akondy, E.E. West, Z. Wei, P. Lu, J.W. Austin, J.L. Riley, J.M. Boss, and R. Ahmed. Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8+ T cells. Immunity. 35: 400-12, 2011. PMCID: PMC3183460. *These authors contributed equally to this manuscript. 4. Oestreich, K.J., A.C. Huang, and A.S. Weinmann. The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. J. Exp. Med. 208: 1001-13, 2011. PMCID: 3092354. 5. Kao, C., K.J. Oestreich, M.A. Paley, A. Crawford, J.M. Angelosanto, M.A.A. Ali, A.M. Intlekofer, J.M. Boss, S.L. Reiner, A.S. Weinmann, E.J. Wherry. T-bet represses expression of PD-1 and sustains virus-specific CD8 T cell responses during chronic infection. Nat. Immunol. 12: 663-671, 2011. PMCID: 3306165. 6. Clauson, C.L., K.J. Oestreich, J.W. Austin, and P.W. Doetsch. Abasic sites and strand breaks in DNA cause transcriptional mutagenesis in Escherichia coli. Proc. Natl. Acad. Sci. 107: 3657-62, 2010. PMCID: PMC2840506. 7. Oestreich, K.J., H. Yoon, R. Ahmed, and J.M. Boss. Regulation of programmed death-1 by NFATc1 upon T cell activation. J. Immunol. 181: 4832-9, 2008. PMCID: PMC2645436. 8. Osipovich, O., R. Cobb, K.J. Oestreich, S. Pierce, P. Ferrier, J. Chen, and E. Oltz. Essential function for SWI/SNF chromatin-remodeling complexes in the promoter-directed assembly of TCRb genes. Nat. Immunol. 8: 809-16, 2007. 9. Oestreich, K.J.*, R. Cobb*, S. Pierce, J. Chen, P. Ferrier, and E. Oltz. Regulation of TCRb gene assembly by a promoter/enhancer holocomplex. Immunity 24: 381-91, 2006. *These authors contributed equally to this manuscript. Invited Reviews 1. Oestreich, K.J. and A.S. Weinmann. Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors. Nat. Rev. Immunol. 12: 799-804, 2012. PMCID: PMC3584691. 2. Oestreich, K.J. and A.S. Weinmann. Transcriptional mechanisms that regulate T helper 1 cell differentiation. Curr. Opin. Immunol. 24: 191-5, 2012. PMCID: PMC3319510. 3. Oestreich, K.J. and A.S. Weinmann. T-bet employs diverse regulatory mechanisms to repress transcription. Trends Immunol. 33: 78-83, 2012. PMCID: PMC3273642. 4. Oestreich, K.J. and A.S. Weinmann. Encoding stability versus flexibility: Lessons learned from examining epigenetics in T helper cell differentiation. Curr. Top. Microbiol. Immunol. 356: 145-164, 2012. 5. Oestreich, K.J. and A.S. Weinmann. Ikaros changes the face of NuRD remodeling. Nat. Immunol. 13: 16-18, 2012. 6. Cobb, R.*, K.J. Oestreich*, O. Osipovich*, and E. Oltz. Accessibility control of V(D)J recombination. Advances in Immunology 91: 91:45-109, 2006. *These authors contributed equally to this manuscript. Research Conference Presentations Read, K.A., McDonald, P.W., Baker, C., Cooley, I., and K.J. Oestreich. Identification of molecular mechanisms that regulate T helper 1 cell plasticity. American Association of Immunologists, Annual Meeting, Pittsburgh, PA, 2014. Read, K.A., McDonald, P.W., and K.J. Oestreich. How do lineage-defining transcription factors regulate immune cell development and function? Southwest Virginia Life Sciences Forum, Roanoke, VA, 2014. Oestreich, K.J., S.E. Mohn, and A.S. Weinmann. The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. Gene Expression and Signaling in the Immune System, FASEB Meeting, Aspen, CO, 2011. Oestreich, K.J., R. Ahmed, J.M. Boss. Regulation of programmed death-1 by a novel NFAT-binding regulatory element. Gene Expression and Signaling in the Immune System, Cold Spring Harbor, NY, 2008. Oestreich, K.J., R. Ahmed, J.M. Boss. Transcriptional regulation of programmed death-1, Mechanisms of Eukaryotic Transcription, Cold Spring Harbor, NY, 2007. Oestreich, K.J., S. Pierce, E. Oltz. Promoter-directed remodeling of local chromatin regulates V(D)J recombination. International FOCIS meeting, Montreal, Canada, 2004. Academic and Professional Honors 2015 AAI Pfizer-Showell Award Recipient 2015 Invited speaker, Roanoke College 2014 Invited speaker, Virginia-Maryland Regional College of Veterinary Medicine 2014 Invited speaker, Modeling Mucosal Immunity Symposium, Virginia Bioinformatics Institute 2013-Present Member, The American Association of Immunologists (AAI) 2012 2012 2011 2011 2008-2009 2006-2008 2006 Invited speaker, Earl Stadtman Immunology Symposium, National Institutes of Health Article of the Month designation for: Oestreich, K.J., S.E. Mohn, and A.S. Weinmann. Molecular mechanisms that control the expression and activity of Bcl-6 in Th1 cells to regulate flexibility with a Tfh-like gene profile. Nat. Immunol. 13: 405-11, 2012. “Faculty of 1000” designation for: Oestreich, K.J., A.C. Huang, and A.S. Weinmann. The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. J. Exp. Med. 208: 1001-13, 2011. “Faculty of 1000” designation for: Youngblood, B*, K.J. Oestreich*, S.J. Ha, J. Duraiswamy, R.S. Akondy, E.E. West, Z. Wei, P. Lu, J.W. Austin, J.L. Riley, J.M. Boss, and R. Ahmed. Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8+ T cells. Immunity. 35: 400-12, 2011. Developmental Immunology institutional training grant recipient Ruth Kirschstein institutional postdoctoral training grant recipient “Faculty of 1000” designation for: Oestreich, K.J.*, R. Cobb*, S. Pierce, J. Chen, P. Ferrier, and E. Oltz. Regulation of TCRb gene assembly by a promoter/enhancer holocomplex. Immunity 24: 381-91, 2006.