Partners Research Studies Seeking Volunteers
Healthy Volunteer Studies
1. Affect and the Mechanisms of Visual Attention In Aging
HELP DISCOVER THE NEUROBIOLOGY OF WISDOM:
BRAIN IMAGING & SOCIAL DECISION MAKING STUDY
Healthy adult participants (60-90 years of age) are needed for a research study of brain
function and social decision making.
Participants will undergo:
1) A 1.5 to 2.5 hour clinical evaluation involving memory, personality, cognitive and
socioeconomic measures.
2) A separate 1.5 to 2 hour functional magnetic resonance imaging (fMRI) study while
viewing emotional and neutral pictures or words on a screen.
Only right-handed individuals age 18 years or older, without pacemakers, aneurysm clips,
or other metallic objects in the head and upper body are eligible for fMRI. Participants
will be paid $150 in total for their time.
If you are interested in participating, please contact Rebecca Dautoff at the Massachusetts
General Hospital, 617-643-5157, for further information.
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1773
2. Risk Factors for Adverse Outcomes in Young Offspring of Bipolar Children
Do you have a child age 2-5 years?
If so, and if neither you nor your child's other parent has a history of depression or mood
disorder, we would welcome your participation in our research study at the
Massachusetts General Hospital, funded by the National Institutes of Health. We are
looking at whether childhood behavioral characteristics can predict later behavior.
The study offers:
. Yearly diagnostic screenings at no cost
. A detailed behavioral and cognitive evaluation
of your child (and his/her older siblings) one year from
the initial assessment at 4, 5, or 6 years of age.
. Monetary compensation for you or your child for each assessment
For more information, contact Marisa at (617) 503-1409 or see our web site at
www.massgeneral.org/pediatricpsych. See the study "Risk Factors for Adverse Outcome
in Young Offspring of Bipolar Parents."
Posted 9/24/08
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000315
3. Assessment of Cardiovascular Risk in HIV Patients
Healthy African American Women for Research Study
You may be eligible for a 2 year research study taking place at Massachusetts General
Hospital.
. . Age 35-50 years old
. . Study involves: 6 visits at the MGH General Clinical Research Center over 2 years,
this study does not involve the use of medication.
Subjects receive comprehensive evaluations and up to $300
Please contact Kathleen Fitch, FNP 617-724-8015 or Sara Dolan Looby, PhD, ANP 617726-1423
MGH Program in Nutritional Metabolism
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000313
4. Do You Have Dandruff
Do You Have Dandruff
You may qualify for a research study of an approved foam medication in Seborrheic
Dermatitis
If you are 12 years or older
7 study visits over 52 weeks
Compensation Available
For more information please call (617) 726-5066 or e-mail
harvardskinstudies@partners.org
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000284
5. The Natural History of Children with Persistent Gastroesophageal Reflux
Disease (ages 12 years to 17 years)
RSVP Announcement
Drs. Harland Winter and Paul Rufo at Massachusetts General Hospital for Children and
Children's Hospital in Boston are excited to be conducting a research study that should
help us learn what happens to children with gastroesophageal reflux disease (GERD)
when they become adults. Information collected in this study will give us a better
understanding of how reflux disease affects the health of children and adults, helping
physicians improve the care and quality of life of their patients with GERD. This study is
Posted 9/24/08
sponsored by AstraZeneca, Inc. We have identified you as a potential control for the
study and are writing to see if you are interested in participating.
If you qualify as a control and would like to participate in the study, we will send you a
questionnaire regarding information about you (such as your age, marital status, and
occupation) and your current health or quality of life. You may fill out the questionnaire
at your convenience and mail back to us in a pre-paid envelope. All of your responses
will remain confidential. You can withdraw from participation, or refuse to answer any
questions, at any time. Upon receipt of your completed questionnaire, you will be
compensated with $25 for your time. Please wait 2-3 months for your reimbursement to
be processed.
If you have any questions regarding the study, please contact our research assistant by email at mawashek@partners.org. Contacting us by e-mail is preferred and please wait 3-4
business days for us to reply to your e-mail. If you choose to contact us by phone, please
wait 10 business days before contacting us again.
We appreciate this opportunity to study gastroesophageal reflux, and we very much hope
that you will agree to participate in this study. If you are interested in participating in the
study and would like to find out if you qualify, please contact our research assistant at
mawashek@partners.org and leave your name, mailing address and phone number. The
study results will contribute greatly to improving the care of children and adults with
gastroesophageal reflux.
RSVP Protocol Number: 2007P000906 (for study sponsored by AstraZeneca, Inc.)
RSVP Fund Number: 1200202492
617-243-6155
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1755
6. An fMRI Study of the Modulation of Cognition by Emotion
Have you never been diagnosed with a psychiatric disorder?
Do you not have any metal in your body (e.g., heart pacemakers, aneurysm clips, or other
metallic objects)?
In case you answered these questions with 'yes', you might be eligible to participate in a
study at the Massachusetts General Hospital (MGI-I)/Harvard Medical School. The entire
study will not take longer than 2.5 hours to complete, and you will receive $100 dollars
for the completion of the study. Specifically, the study will involve a brief interview,
filling out questionnaires, and completing some tasks while "pictures" of your brain are
taken using functional Magnetic Resonance Imaging (fMRI). Only individuals without
pacemakers, aneurysm clips, or other metallic objects in the head and upper body are
eligible for fMRI.
Posted 9/24/08
If you are interested in participating or would like to get further information, please call
Lindsay at 617-643-5129 at the Massachusetts General Hospital (MGH), Psychiatric
Neuroscience Program, or email her at lcarlson2@partners.org
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1750
7. Neural Correlates of Behavior Therapy in Tourette's Syndrome
Normal Control Subjects Wanted for A Study Of Brain Function in People Who Suffer
From Tourette's Syndrome
Dr. Thilo Deckersbach of the Psychiatry Department at the Massachusetts General
Hospital is conducting a research study to examine brain function in people who suffer
from Tourette's Syndrome, as compared with those who do not.
The entire study will consist of 2 study visits that will each take approximately 2 - 2 ½
hours and will involve a clinical evaluation, filling out questionnaires, and completing
cognitive tasks while "pictures" of your brain are taken using functional Magnetic
Resonance Imaging (MRI). Only individuals without pacemakers, aneurysm clips, or
other metallic objects in the head and upper body are eligible for MRI. Participants will
be paid $100 for each study visit and will be provided with a parking pass if they park at
the MGH-Charlestown Navy Yard parking garage.
If you are between the ages of 18-64, are without any psychiatric disorders, and are
interested in this study, please contact Lindsay at 617-643-5129 or email
lcarlson2@partners.org.
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1749
8. Do you have ACNE ON YOUR BACK?
You may qualify for a research study of a birth control pill versus placebo (placebo
contains no active medication).
If you are Female and 18-45 years old
Desire birth control
6 study visits over 24 weeks
Must use other form of birth control during study
Up to $300 in compensation for time and travel
For more information, please e-mail harvardskinstudies@partners.org or call (617) 7265066
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000285
Posted 9/24/08
9. Laboratory Evaluation of Neuropathic Pain
Are you healthy and between 40 and 49 years old?
We seek men and women to participate as healthy controls (comparison group) for a
diabetes research study. You must have never had diabetes. This study involves a single
visit to the Mass General hospital during which you will have a glucose tolerance test to
screen for diabetes. Recent normal results of this test can be used instead. You will also
have two small punch skin biopsies removed from your lower leg under local anesthesia.
Payment for participation is offered. For more information, please contact Heather
Downs of the MGH Neurology Department at 617-726-0260 (HDowns@partners.org).
IRB#99-9042
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000302
10. Magnetic Resonance Spectroscopy in Children at Risk for Mood Disorders
We are looking for healthy families, with youth ages 6-24 years, and their parents who do
not have a history of mood disorders, to participate in a neuroimaging study. This study
looks at differences in brain chemicals among youth at higher and lower risk for bipolar
disorder. Both parental and youth involvement is necessary.
We are interested in making sure that we have balanced representation of African
American, Asian American and Latino families in our sample, so that our findings may
help us learn about the community at large.
The study offers:
. Two brain scans (an MRI and an MRS scan) at no cost
. An evaluation of emotional and behavioral functioning
. An evaluation of intellectual strengths and weaknesses
. Monetary compensation for each assessment
. No treatment is provided in this study
For more information, contact Caroline at (617) 503-1411.
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000299
11. Magnetic Resonance Spectroscopy in Children at Risk for Bipolar Disorder
Do you have frequent mood swings? Do you go through times when you feel "too good,"
overly excited or confident, overly active, or unusually irritable? Have you ever been
diagnosed with mania or bipolar disorder? Do you have a child age 6-17 years? If so, we
would welcome your participation in our neuroimaging research study. This study looks
at differences in brain chemicals among children who have a parent with bipolar disorder.
We are interested in making sure that we have balanced representation of African
Posted 9/24/08
American, Asian American and Latino families in our sample, so that our findings may
help us learn about the community at large.
The study offers:
. Two brain scans (an MRI and an MRS scan) of your child at no cost
. An evaluation of your and your child's emotional and behavioral functioning
. An evaluation of your child's intellectual strengths and weaknesses
. Monetary compensation for you or your child for each assessment
. No treatment is provided in this study
Participation involves 2-3 study visits, each lasting 2-5 hours.
For more information, contact Caroline at (617) 503-1411.
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000239
12. Subclinical Atherosclerosis in HIV Infected Men
Healthy Male Volunteers Wanted
.. 40-46 years old
You may be eligible for a research study examining heart disease risk at the
Massachusetts General Hospital (MGH).
Study involves:
.. 2 visits at the MGH Clinical Research Center
.. CT scan of the heart
Subjects receive a comprehensive evaluation and up to a $100 payment for two outpatient
visits.
Please contact Jeffrey Wei at (617) 724-8070.
MGH Program in Nutritional Metabolism
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000287
13. Developing a Workplace Laboratory for Adults with Attention Deficit
Hyperactivity Disorder
Volunteers (18-55 years old) with and without ADHD are invited to participate in a study
investigating how adults with ADHD function while performing tasks similar to those
encountered in the workplace. This study will take up to 16 hours. This time is divided
between the initial visit to obtain consent and complete up to 5 hours of testing, and one
work simulation day lasting from 8:30 am to 7:00 pm. Subjects may be compensated up
to $350. Please contact the study coordinator at (617) 724-8485 or kclaudat@partners.org
for more information.
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000275
Posted 9/24/08
14. Biochemical Changes Correlated with the Antidepressant Treatment of
Escitalopram
Have you been feeling depressed or down? Do you no longer enjoy the things you used
to? Have you been having trouble falling asleep or staying asleep?
If you've answered yes to any of these questions, you could be eligible for a research
study at Massachusetts General Hospital. This study is looking for participants between
the ages of 18 and 65 who are depressed and not currently taking any medication. If
eligible, participants would be put on the FDA approved antidepressant medication
Escitalopram (Lexapro). As part of this study there would be three Magnetic Resonance
Spectroscopy (MRS) scans over the course of 13 weeks. These brain imaging scans
measure the concentrations of several compounds in the brain. These scans would take
place at Mclean Hospital in Belmont, MA and participants will be offered $100
compensation for the first and last scan, $50 for the second, shorter scan, as well as $25
per scan to cover transportation costs to Mclean Hospital. At the end of the study
participants will be offered three months of follow up care at no cost.
For more information contact Vicki at 617-724-9458 or vameral@partners.org
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1725
15. Behavioral, Structural, and Functional Effects of Meditation
Healthy volunteers needed to participate in a neuro-imaging study on brain function.
Participate and receive a fMRI scanned picture of your brain!!!! (note: not a diagnostic
image but looks great on your refrigerator)
Study requires 4.5 to 5 hours of your time at the neuro-imaging lab at Mass-General
Hospital, Charlestown, in addition to on-line questionnaires.
Participants must:
be between the ages of 40 and 70
have no yoga or meditation experience
be a non-smoker
not be taking medication for a psychological/psychiatric condition
Participants will also be compensated $100 for their time
If interested, please contact: lazar-lab@nmr.mgh.harvard.edu, or call: 617-724-2256
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000273
Posted 9/24/08
16. Evaluation of Digital Subtraction Bowel Cleansing and Automated Polyp
Detection in CT Colonography (Virtual Colonoscopy)
Do you have a Colonoscopy appointment?
Seeking volunteers for a research study evaluating Virtual Colonoscopy
using a laxative-free bowel preparation
Description: CT colonography (Virtual Colonoscopy) consists of a low X-ray dose CAT
scan, which is performed after gently filling the colon with carbon dioxide. The images of
the colon are reconstructed into a computer model, which allows for a minimallyinvasive screening of the colon for abnormalities such as polyps and masses. Instead of
drinking a laxative to empty the bowel prior to the colon test, study participants drink a
contrast solution during the laxative-free bowel preparation. The contrast solution allows
for the computer model of the bowel to be cleansed electronically. Thus, the laxative-free
bowel preparation regimen is intended to be more comfortable for patients than current
bowel preparations.
You may be eligible to participate in the research study if you:
1. Are 50-80 years old
2. Have a Colonoscopy scheduled at Massachusetts General Hospital, Brigham and
Women's Hospital, Newton Wellesley Hospital, or North Shore Medical Center
3. Have a Colonoscopy scheduled either for routine colon screening or because of a
family history of colon cancer or a change in bowel habits.
4. Have not had a Colonoscopy or Sigmoidoscopy in the past 5 years
The standard colonoscopy is REQUIRED for inclusion in the study, as part of a reference
standard comparison.
Participants in this research study:
1. Must be available for two study visits at an MGH location: a 30 minute information
visit and a 30 minute CT Colonography test (total duration of second visit: 1hour).
2. Will be asked to follow a low fiber diet as well as drink a small amount of contrast
solution with meals and snacks for the two days prior to the second visit
(i.e., prior to the CT colonography).
3. Will receive study related laxative-free bowel prep and CT Colonography test at no
cost.
4. Must undergo Colonoscopy between 1-4 weeks after the CT Colonography test.
(The cost of the Colonoscopy is not covered by the study.)
Participants will receive free parking for the two study visits, plus a $70 payment for
participation upon completing all study requirements.
Interested individuals or their physicians should contact Dr. Michael Zalis
via phone 617-724-2628 or e-mail: mzalis@partners.org. Please state in your call that
you are responding to this letter.
Posted 9/24/08
Thank you for your time and interest in clinical research.
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000271
17. hCAP18 and Vitamin D deficiency in Healthy Subjects
RESEARCH STUDY NOTICE
Healthy Volunteers Wanted
For a research study on
Vitamin D Deficiency and Immune Defense
Vitamin D deficiency is a common problem in the Boston area. Most people with
Vitamin D deficiency do not know they have it.
We are looking for healthy volunteers, ages 18-80, to participate in a research study of
vitamin D and the immune system. We will check blood levels of vitamin D levels and a
protein involved in immune defense.
Participants found to be vitamin D deficient will be offered vitamin D supplements and
return in two weeks for repeat levels.
There will be no cost to anyone who participates. No investigational drugs will be used.
All individuals welcome. Women and minorities are encouraged to participate.
For more information, contact Dorrie Sullivan, RN at dsullivan18@partners.org or 617726-5382.
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1719
18. Metabolic Alterations in Women with a History of Hypertensive Disorders of
Pregnancy
MOMS
MGH Obstetrical Maternal Research Study
Did you have a baby at MGH within the past three years?
If so, consider becoming a part of MOMS, the MGH Obstetrical Maternal Study. Being a
part of this research study will help the medical community understand why women who
develop high blood pressure or high blood sugar during pregnancy are at increased risk of
developing high blood pressure or high blood sugar later in life.
This research study involves one 3-4 hour visit to the Clinical Research Center at MIT,
and includes fasting blood and urine tests, an oral glucose tolerance test, and timed blood
Posted 9/24/08
tests. Your participation will help us reach our goal of understanding and treating this
condition. You will be paid $150 for participating in this research study.
For more information, or to schedule a visit, please contact Dorrie Sullivan, RN at 617726-5382
Or DSullivan18@partners.org
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1717
19. Electroencephalogram Studies of Induction and Recovery from Propofol
Induced General Anesthesia
The Mass General Hospital Department of Anesthesia and Critical Care is recruiting
healthy, non-smoking adults, ages 18-36 years for a research study to identify the sites of
action of propofol anesthesia in the brain. We will be using magnetic resonance imaging
(MRI) and electroencephalogram (EEG) to observe brain activity. Studies will be
conducted at the MGH General Clinical Research Center in the Charlestown Navy Yard,
and will consist of a physical exam and a 7-hour imaging/EEG/anesthesia session. Two
or three visits will be required to complete the study. Subjects will receive up to $200 for
completion of the study. For more information, please contact Dr. Emery N. Brown in the
MGH Department of Anesthesia and Critical Care at 617-724-9857 or at
mgh.anesthesia.study@gmail.com http://neurostat.mgh.harvard.edu/anesthesia_eeg.htm.
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1704
20. Late-Onset Alzheimer's Disease Family Study
The purpose of this study is to study the inherited causes of Alzheimer's Disease (AD) by
collecting blood samples and other types of research data for a national registry known as
the National Cell Repository for Alzheimer's Disease (NCRAD), which is located at
Indiana University. The study includes individuals with AD and certain family members.
Participation requires the collection of blood samples, data of memory tests, and
permission to review medical records pertaining to the medical history of individuals
with AD and their family members. We cover all costs, and travel to Boston is not
necessary. Arrangements will be made for participants to have their blood drawn locally.
Eligibility Criteria:
Two siblings who were both diagnosed with AD at or after age 60, and at least one other
close relative (sibling, half-sibling, parent, aunt, uncle, first cousin, niece, nephew, or
child) who is at least age 50 who may or may not have AD.
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1517
Posted 9/24/08
Disease-Specific Studies
21. Study about Memory Problems in Bipolar Disorder
Do you have bipolar disorder?
Do you have difficulty remembering things?
If so, you may be eligible to participate in a research study at Massachusetts General
Hospital's Bipolar Clinic and Research Program examining the effect of a medication
treatment on memory functioning in patients with bipolar disorder.
Participation includes 12 weeks of treatment with memantine or placebo (contains no
active medication), two sessions of neuropsychological testing, and a total of five
research study visits. Subjects will also be compensated for participation.
Who is eligible? Bipolar patients between the ages of 18 to 65 who report memory
difficulties and who have NOT had an acute episode of mania/hypomania and/or
depression in the last three months. Pregnant women and women able to get pregnant
who are not using a medically accepted means of contraception (birth control) are not
eligible.
Contact: The Massachusetts General Hospital's Bipolar Clinic and Research Program at
1-866-99-MOODS for more information.
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000319
22. The oral contraceptive pill to treat premenstrual worsening of depression.
Seeking women between 18-45 with PMS who have been diagnosed with depression.
If you are between 18 and 45 and:
. Suffer with PMS
. Currently being treated with an antidepressant
You may be eligible for a research study at Massachusetts General Hospital evaluating
how a birth control helps with premenstrual mood symptoms.
Women who participate will receive study medication and evaluations of their mood at
no cost, and will be compensated up to $450.
For information, please call: (617) 724-6540 or email afarrell2@partners.org
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000318
Posted 9/24/08
23. Does Memantine Improve Verbal Memory Task Performance in Subjects with
Left Temporal Lobe Epilepsy and Memory Dysfunction? A Randomized, DoubleBlind, Placebo-Controlled Trial.
Does memantine improve verbal memory task performance in patients with left temporal
lobe epilepsy and memory dysfunction? A randomized, double-blind, placebo-controlled
trial.
Many patients with epilepsy have memory deficits. Unfortunately, the treatment options
for memory dysfunction in patients with epilepsy are limited. We are conducting a study
to evaluate the effects of memantine, a medication used for the treatment of Alzheimer's
Disease, for the treatment of verbal memory dysfunction in subjects with left temporal
lobe seizures. The study involves randomization to memantine therapy or placebo, with
cognitive testing and EEG pre- and post-treatment.
All subjects must:
. Be 18-55 years of age
. Have left temporal lobe seizures
. Be native English-speaking
. Be able to give consent
. Have self-reported memory dysfunction
Participation will require two study visits over the 13-week duration of the trial. Each
subject will be offered $100 dollars for participation, parking and meal vouchers, as well
as free study medication during the trial.
If you or your doctor feel that you might be a candidate for this study, or if you wish to
obtain more information, please contact:
Beth Leeman, M.D.
Phone: 617-726-3311
E-mail: baleeman@partners.org
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000317
24. Cognitive Effects of Treatment of Interictal Discharges
Cognitive effects of treatment of interictal discharges
Many patients with epilepsy have subtle or transient cognitive deficits in the setting of
otherwise normal intelligence. It is thought that frequent interictal discharges may
contribute to this phenomenon. It is unknown, however, whether treatment of the
discharges will improve cognitive performance. We are conducting a study to evaluate
the effects of treatment of focal or generalized interictal discharges with levetiracetam or
lamotrigine, respectively. We will be assessing whether these drugs do in fact reduce
abnormal interictal activity, and whether this reduction correlates with improved
cognitive task performance. The study involves patients diagnosed with seizures, who
Posted 9/24/08
will be placed on levetiracetam monotherapy for focal seizure prevention or lamotrigine
monotherapy for generalized seizure prevention. The study will include subjects with and
without frequent interictal epileptiform discharges. Subjects will undergo repeated EEG
and cognitive testing pre- and post-treatment. The trial duration is 11 weeks for those
taking levetiractam, and 15 weeks for those taking lamotrigine.
Subjects with epilepsy must meet criteria which include:
● 18-55 years of age
● The subject's treating physician is planning to prescribe levetiracetam for focal
seizure or lamotrigine for generalized seizure prevention
● Untreated with antiepileptic medications at the time of enrollment
We are also recruiting healthy adult control subjects, aged 18-55 years, to undergo EEG
and cognitive testing without taking medication. Healthy controls will participate in three
testing sessions over 15 weeks.
If you or your doctor feel that you might be a candidate for this study, or if you wish to
obtain more information, please contact:
Beth Leeman, M.D.
Phone: 617-726-3311
E-mail: baleeman@partners.org
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000316
25. Is Your Hair THINNING?
Is your Hair THINNING?
You may qualify for a research study:
Caucasian men 20-50 years of age
Have scalp bald spot 1" wide or greater
Up to 8 study visits
Will not treat baldness
Up to $750 in compensation
Please call (617) 726-5066
or e-mail harvardskinstudies@partners.org
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000312
26. An Efficacy and Safety Study of Reslizumab (CTx55700) in the Treatment of
Poorly Controlled Asthma in Subjects with Eosinophilic Airway Inflammation
Do You Suffer From Asthma?
Posted 9/24/08
If you have moderate or severe asthma, find out if you qualify for a clinical research
study for an investigational asthma medication. You may be eligible if you:
. Take Inhaled Corticosteroids (i.e. Flovent 220 or Advair 500/50) and at least one
otherasthma medication
. Are between the ages of 18-75
We are recruiting subjects now! Participants will be seen by a medical doctor and receive
study medication or placebo (contains no active medication) at no cost. It involves 7
study visits over an 18-week period and involves 4 infusions. Compensation is up to
$600. For more information, please contact:
[Asthma Research Center, 1-888-99-ASTHMA or www.asthmaBWH.org or
ARC@Partners.Org]
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1760
27. Understanding Racial/Ethnic Differences in CAHPS Ratings
Volunteers over the age of 18 are invited to participate in a study investigating the
relationship between patient satisfaction ratings and race/ethnicity.
You will be asked to view a short video of a doctor and patient speaking together
(approximately 5 minutes), and to answer questions about your opinions of the video.
Combined, this will take approximately 20 minutes.
The video viewing and questions will take place on the 9th floor of 50 Staniford Street, a
short 5 minute walk from the main MGH campus.
Please contact one of the members of our research study staff, Steffanie Bristol, at 617643-2821 or at sbristol@partners.org for more information.
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000311
28. DO YOU HAVE PSORIASIS?
You may be eligible to participate in a research study of an investigational medication
12 years of age or older
Up to 20% of skin affected
4 visits with a dermatologist over 8 weeks
Up to $260 compensation for travel & parking
For more information:
Please call (617) 726-5066 or email harvardskinstudies@partners.org
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1758
Posted 9/24/08
29. Do ou Have FACIAL ACNE?
You may qualify for a research study of an investigational gel medication
If you are 12 years or older
5 study visits over 12 weeks
Up to $200 in compensation for time and travel
For more information, please e-mail harvardskinstudies@partners.org or Call
(617) 726-5066
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000309
30. Do you have HIDRADENITIS SUPPURATIVA (Boil-like lesions, abscesses and
scars on the armpits and groin)?
You may qualify for a research study of an investigational oral medication
Females - 14-45 years of age
9 study visits over 6 months
Compensation up to $360 for time and travel
For more information, please e-mail harvardskinstudies@partners.org
or call (617) 726-5066
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000304
31. Reduced Phosphate Intake in "Normo-Phosphatemic" Chronic Kidney Disease
Patients
We would like to study the role of phosphorous metabolism in the development of certain
hormonal problems in people with Chronic Kidney Disease. More specifically, the goals
of the research are (1) to understand the cause of hyperparathyroidism - a hormone
problem that often develops in patients who have kidney disease and (2) to test whether
decreasing phosphorus intake could help improve or prevent hyperparathyroidism.
Eligible subjects will be people with reduced kidney function who are 18 years of age or
older. Subjects will have nine visits over approximately one month. For two weeks
during this time, subjects will consume a controlled phosphorus diet provided by the
clinical research center. Some subjects will be prescribed a phosphorus binding tablet to
limit the absorption of phosphorus in the gut. Subjects will be compensated for
completing the protocol.
Please contact Mike at (617) 724-3416 for more information.
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000305
Posted 9/24/08
32. Clinical Management of Neuropathic Pain with Ramelteon
Do you have nerve pain?
If so, we welcome you to participate in our research study at the Massachusetts General
Hospital Center for Translational Pain Research. We are evaluating the effectiveness of a
FDA-approved sleep medication on nerve pain. If you are 18-65 years old and have been
diagnosed with a nerve pain condition for at least 3 months you may be eligible to
participate.
The study consists of:
four study visits;
two phone interviews;
keeping sleep and pain diaries;
completing questionnaires;
a urine test;
a brief office physical exam
taking study medication.
Compensation will be provided.
For further information, please contact:
Charlene Malarick, RN, BSN at
617 724-6102 or toll-free at 1-888-No-2-Ouch
cmalarick@partners.org
www.massgeneral.org/painresearch
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1752
33. Memory Reconsolidation Blockade as a Novel Intervention for Nicotine
Dependence
Have you quit in the past but resumed smoking?
Have you been smoking 10 or more cigarettes a day for the past 6 months?
Are you between the ages of 18 and 65?
We are conducting a 12-week smoking cessation and relapse prevention research study.
The purpose of this study is to find out whether a medication called propranolol can help
to prevent people from having a smoking relapse by reducing cravings to smoke.
The study involves a smoking cessation phase, where you will be given nicotine patches
at no cost to help you quit smoking, and a relapse prevention phase where you will be
assigned to receive either propranolol or placebo (contains no active medication) once a
week for 6 weeks.
Posted 9/24/08
Study participation involves weekly visits to our clinic at Massachusetts General
Hospital. You may be eligible to participate in the study at no cost to you. Compensation
up to $300 and free parking will be provided.
If interested, please call 617-643-4691 or email Dr Pachas at gpachas1@partners.org.
All inquiries are completely confidential.
IRB #2007-P-001903
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1747
34. A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Multicenter
Study to Evaluate the Efficacy and Safety of Ad5FGF-4 in Female Patients With
Stable Angina Pectoris Who are Not Candidates for Revascularization.
Researchers at Massachusetts General Hospital in Boston, MA are currently enrolling
women who suffer from chest pain due to heart disease. If you have had a prior bypass
graft or stent procedure but still have chest pain, and can take an exercise treadmill test,
you may be eligible to enroll in this research study. The study includes 2-3 screening
visits, 6 study visits, and yearly phone follow-up for four years. The study will reimburse
out-of-pocket expenses. If you are interested in participating or would like more
information please contact Voula Christopoulos, the research coordinator, at 617-6432890 or by e-mail at vchristopoulos1@partners.org
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1744
35. Reducing High Risk Behaviors Among Bipolar Patients Transitioning to
Adulthood
Do you have frequent mood swings? Do you go through times when you feel "too good,"
overly excited or confident, overly active, or unusually irritable? Have you ever been
diagnosed with mania or bipolar disorder? Are you between the ages of 18 and 24 years?
If so, we would welcome your participation in our study of cognitive behavioral therapy
(CBT) for bipolar disorder in young adults. This study uses CBT strategies for:
1) Learning to manage symptoms of bipolar disorder
2) Improving problem-solving and daily functioning skills
3) Enhancing health-promoting behaviors
The intervention consists of 14 60-minute individuals sessions.
The intervention is provided is at no cost.
For more information, please contact Caroline at 617-503-1411.
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000301
Posted 9/24/08
36. Behavioral modifications and Lorcaserin for Overweight and Obesity
Management in Diabetes Mellitus A 52-Week, Double-blind, Placebo-controlled,
Parallel-group Study to Assess the Safety and Efficacy of Lorcaserin Hydrochloride
in Overweight and Obese Patients with Type 2 Diabetes Mellitus Managed with
Oral Hypoglycemic Agent(s)
The MGH Weight Center is now enrolling for a new clinical trial for the treatment of
diabetes and obesity!
You may be eligible to take part in a clinical research study with an experimental drug for
the treatment of diabetes and obesity. This medication has shown to help short-term (12week) weight loss in previous studies and will be tested to determine effectiveness for
long-term weight loss.
The study will run for 64 weeks. Study related exams and drug as well as periodic
nutritional counseling will be provided free of charge for those who qualify.
Remuneration of up to $700 will also be provided.
The study will consist of:
. taking a study drug or placebo (sugar pill - no active medicine or drug ) for 1 year
If you take part in this study, you may not get the study drug
. individual nutritional counseling
. monthly visits to the MGH Weight Center to meet with the study team and dietitian
Eligible subjects must:
. be between the ages of 18 and 65
. have Type-II diabetes
. be overweight
. willing and able to commit to the study and taking the medication (or placebo) for 1
year
Institution - Massachusetts General Hospital, Boston, MA
Principal Investigator - Lee M. Kaplan, MD, PhD
Enrollment Information
For further information about enrolling a patient in this trial, contact the person below.
Name - Anna Moseman, Study Coordinator
Email - amoseman@partners.org
Phone - 617-724-9616
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000296
Posted 9/24/08
37. Brain Function, Structure and Genes in Obsessive Compulsive Disorder
Children Ages 10-17 Wanted for a Study of Brain Function, Structure and Genes in
Obsessive Compulsive Disorder (OCD)
Is there a 10-17 year old child in your family who suffers from unwanted thoughts,
worries and behaviors that they can't stop or who has been diagnosed with obsessive
compulsive disorder (OCD)?
If so, this child could participate in a research study at the Massachusetts General
Hospital (MGH) and McLean Hospital.
The purpose of this study is to learn more about OCD. We are interested in learning more
about how the brain functions and how certain genes affect the brain in people with OCD
compared to people who do not have OCD.
Participants will be interviewed by a study doctor and will undergo structural and
functional magnetic resonance imaging (MRI) to take pictures of their brains. We will
also collect a saliva sample from participants to look at their genes.
This study will require two study visits, each lasting approximately 1.5-2 hours.
Participants must be right-handed.
Children will receive up to $125 in gift certificates for their participation.
Note: MRI uses strong magnets and people with metal in their body may not be able to
participate.
For more information on how to participate, please call the study coordinator at (617)
855-2239 or email lmanning@mclean.harvard.edu.
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000293
38. Omega 3-Fatty Acids for Treatment of Major Depression: Differential Effects of
EPA and DHA, and Associated Biochemical and Immune Parameters
Omega-3 EPA vs. DHA Fatty-Acid Depression Study
Do you feel sad, blue, or down in the dumps?
Do you no longer enjoy the things you used to?
Do you have trouble falling asleep, staying asleep?
Do you feel tired all the time, even after a good night's sleep?
These might be the symptoms of what researchers refer to as major depression. It is
believed that a deficiency of Omega-3 fatty acids can lead to the development of major
depression. Omega-3 fatty acids such as EPA and DHA are commonly found in fish oils,
Posted 9/24/08
for instance Salmon, Mackerel, and Tuna. If untreated, depression can affect a person's
daily functioning and quality of life. If you are at least 18 years old and have symptoms
of depression, you may be eligible to participate at no cost in a Massachusetts General
Hospital research study that evaluates the two natural supplements, EPA and DHA
Omega-3 fatty acid, as a treatment for depression.
For more information about this and other studies, please contact 1-877-55-BLUES or
email Soo at syoun@partners.org.
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1739
39. A Double-Blind, Placebo Controlled Study of Maca Root for the Treatment of
Sexual Dysfunction Associated with the Treatment Regimen for Bipolar Disorder in
Females
Are you taking medication for bipolar disorder and experiencing sexual side effects?
If you are a female, aged 18-80 and experiencing sexual dysfunction due to psychotropic
medications for bipolar disorder, you may be eligible to participate at no cost to you in a
12-week research study of a natural compound called Maca Root. Maca Root has been
used for centuries in South America for nutritional and medicinal purposes. This study is
designed to determine whether Maca Root is effective in the treatment of sexual
dysfunction associated with the treatment regimen for bipolar disorder.
If interested, please call Lara Sinicropi-Yao @ 617-726-3129 or LSinicropiYao@partners.org. All inquiries will be completely confidential.
This study is being conducted by the Depression Clinical and Research Program at The
Massachusetts General Hospital.
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1737
40. A Double-Blind, Placebo Controlled Study of Maca Root for the Treatment of
Antidepressant Induced Sexual Dysfunction in Females
Are you taking antidepressants and experiencing sexual side effects?
If you are a female, aged 18-80 and experiencing sexual dysfunction due to
antidepressant medication, you may be eligible to participate at no cost to you in a 12week research study of a natural compound called Maca Root. Maca Root has been used
for centuries in South America for nutritional and medicinal purposes. This study is
designed to determine whether Maca Root is effective in the treatment of antidepressant
induced sexual dysfunction.
If interested, please call ]Lara Sinicropi-Yao @ 617-726-3129 or LSinicropiYao@partners.org. All inquiries will be completely confidential.
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1736
Posted 9/24/08
41. Cognitive-Behavior Therapy for Depression in Bipolar Disorder
The MGH Bipolar Clinic and Research Program is currently seeking volunteers to
participate in a research study evaluating a psychosocial therapy for the treatment of
depressive symptoms in patients with bipolar disorder. In this study, patients will receive
18 sessions of therapy for bipolar depression and a brain scan at no cost.
Bipolar patients above the age of 18, who are currently in a depressive episode, please
contact Rebecca Ametrano at rametrano@partners.org or call (617)-724-6545 for more
information. IRB#2006P001521
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000289
42. A three-phase study designed to test the efficacy, tolerability and safety of the
combination of Ziprasidone with the selective serotonin reuptake inhibitor (SSRI)
Escitalopram for patients with Major Depressive Disorder (MDD) that do not
sufficiently respond to treatment with Escitalopram
The current research study is looking for participants between the ages of 18-65, who are
depressed and are not currently taking any medication. If eligible, participants will
receive the FDA approved antidepressant medication Escitalopram (Lexapro) for at least
10 weeks. At the end of 10 weeks, subjects who have improved on the medication will be
offered 3 months of follow up care at no cost. For those subjects who have NOT
improved on the medication, they may be eligible to continue on Lexapro and receive, in
addition, either Ziprasidone or placebo. Placebo is sometimes called a sugar pill, and it
looks like a study drug but it doesn't contain any active medication. At the end of the
study, all participants will be offered 3 months of follow up care at no cost.
For more information about this and other depression studies, please call 1-877-55BLUES or contact Soo directly at 617-724-2936 or syoun@partners.org
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000288
43. Laboratory Evaluation of Neuropathic Pain
Are you healthy and 70 years or older?
We seek men and women to participate as healthy controls (comparison group) for a
diabetes research study. You must have never had diabetes. This study involves a single
visit to the Mass General hospital during which you will have a glucose tolerance test to
screen for diabetes. Recent normal results of this test can be used instead. You will also
have two small punch skin biopsies removed from your lower leg under local anesthesia.
Payment for participation is offered. For more information, please contact Heather
Downs of the MGH Neurology Department at 617-726-0260 (HDowns@partners.org).
IRB#99-9042
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=333
Posted 9/24/08
44. Do you have ASTHMA?
You may be able to participate in a research study.
You MUST be taking an inhaled steroid AND :
- Be 18 - 55 years old
- Have allergic asthma
- Be a lifelong non-smoker
- If female, be post-menopausal or surgically sterile
This study is looking at a new medication for asthma. All study medications and visits are
provided at no cost. Compensation provided.
For more information please contact:
617-726-6376 or mstier@partners.org
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1729
45. A Double-Blind, Placebo-Controlled Trial of the NMDA Glycine Site
Antagonist, GW468816 for Prevention of Relapse to Smoking
Smoking Cessation and Relapse Prevention Research Study
Do you want to quit smoking once and for all?
Have you been smoking 10 or more cigarettes a day for the past 6 months?
If you are a female between the ages of 18 and 65, you may be eligible to participate in
our research study at no cost to you. The study involves an 8-week smoking cessation
phase, where you will be given free nicotine patches to help you quit smoking. If you are
able to successfully quit smoking after 7 weeks of nicotine replacement therapy (i.e. the
patch), you will enter into the 5-week relapse prevention phase of the study where you
will stop using the patch, and you will be randomly assigned to receive an investigational
drug that may be an effective treatment in helping prevent recently quit smokers from
relapsing or placebo (i.e. inactive medication).
Study participation involves weekly or biweekly visits to our clinic at Massachusetts
General Hospital and the completion of computerized and behavioral tasks at three points
throughout the 15-week study. Additional compensation will be provided.
If interested, please call 617-724-8472 or email quitforgood@partners.org. All inquiries
are completely confidential.
More information can be found at :
http://clinicaltrials.partners.org/trials.aspx?tId=100000272
Posted 9/24/08
46. Comparison of LANTUS and NPH in The DAWN PHENOMENON
Subject: Comparison of Lantus and NPH Insulin in the Dawn Phenomenon
Massachusetts General Hospital, Diabetes Research Center, seeks individuals with Type
1 diabetes for a research study to better understand how two different types of long-acting
insulin affect blood sugar control during the early morning hours. Study involves: 1.
Three daytime outpatient visits at the Diabetes Research Center, including nutritional
counseling, teaching of the Continuous Glucose Monitoring System(CGMS). 2. Two
overnight inpatient hospital stays during which blood samples will be obtained through
an intravenous (in the vein) line. Study requirements: Candidates must have Type 1
diabetes for 5 or more years, be between the ages of 18-60, and must use either glargine
(lantus) or NPH insulin. Compensation: Up to $220. All tests and alternate insulins
provided at no cost. For more info :Christine Stevens RN, study coordinator at 617-6430915. IRB#2005-p-002515
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1713
47. Determination of Dosing and Frequency of BCG Administration to Alter TLymphocyte Profiles in Type I Diabetics
People with Type 1 diabetes have abnormal white blood cells in their body. These
abnormal cells - also called "autoreactive cells" - help destroy the cells in the pancreas
that make insulin. When this happens, people develop Type 1 diabetes.
In this study, we will use a vaccine called BCG, which is commonly used to protect
people against tuberculosis, to try to reduce the number of abnormal autoreactive cells.
Researchers have used this vaccine in mice with Type 1 diabetes and it reduced the
number of autoreactive cells and helped cure their diabetes. Now we want to find out if
BCG can reduce the number of these abnormal cells in people with type 1 diabetes.
The study is being conducted at the Diabetes Research Center of Massachusetts General
Hospital.
You may be eligible if you:
Have used insulin continuously since being diagnosed with diabetes
Are aged 18-55
Have an A1C of 8.0 or less
Can come to morning visits starting between 8:00am to 9:30am.
The study involves 17 visits over a 6 month period.
Travel and parking expenses will be reimbursed.
To see if you qualify for the study, or for more information, please contact:
Richard Pompei, RN at rpompei@partners.org or 617-726-2141
Posted 9/24/08
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1712
48. Closed Loop Glucose Control for Automated Management of Type 1 Diabetes
Do you have type 1 diabetes and use an insulin pump? Volunteers wanted for a study of
an automated, closed-loop blood glucose control device.
The MGH Diabetes Center is performing a research study on a device for automated,
closed-loop blood glucose control (sometimes called an "artificial pancreas") in people
with type 1 diabetes. You may be eligible for this study if you are more than 18 years old,
have type 1 diabetes diagnosed at least 5 years ago, use an insulin pump, and have a
hemoglobin A1c of 8.5% or less.
There will be four study visits. The first visit will determine whether you meet all of the
requirements for participation. This visit will take about two hours and involves a
physical exam, a mixed-meal tolerance test, timed blood tests, and an EKG. If you
qualify, we will schedule two 29-hour overnight stays in the General Clinical Research
Center at MGH. Both of these admissions involve insertion of two IV catheters for
frequent blood sampling. During one of the visits you will use your own insulin pump to
control your blood sugar. During the other, your own insulin pump will be removed,
three new infusion sets will be placed, and the closed-loop device will control your blood
sugar by infusion of insulin and glucagon. Two days before the closed-loop visit, there
will be a brief visit to place a small sensor in the skin for continuous glucose monitoring
by the Abbott Navigator. You will need to check your blood sugar three times over the
next two days using the Navigator's built-in meter. During the closed-loop visit you will
also wear two other continuous glucose monitors, the MiniMed Guardian RT and the
Dexcom Seven System. Compensation will be $750 for completion of all four visits. You
may be offered the option to do one more closed-loop visit, in which case the
compensation will be $1050.
For additional information, please contact the study coordinator, Robert Sutherlin, R.N. at
617-724-6237 or email rsutherlin@partners.org. IRB Protocol: 2007p-000101
Version 1, 05-01-08
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1709
49. Bipolar Disorder in Pregnancy and the Postpartum Period: Predictors of
Morbidity
Bipolar Disorder In Pregnancy
Are you an expectant mother? Do you have questions about bipolar disorder and
antidepressants or mood-stabilizers during pregnancy? The Center for Women's Mental
Health at Massachusetts General Hospital is conducting a research study on Bipolar
Disorder in pregnancy. If you are pregnant and diagnosed with bipolar disorder (or manic
depression) you may be eligible for this research study. Participants meet with research
Posted 9/24/08
coordinators and psychiatrists who specialize in bipolar illness during pregnancy. For
more information contact Rachel at (617) 726-2912.
More information can be found at : http://clinicaltrials.partners.org/trials.aspx?tId=1707
Posted 9/24/08