Abstract Past research has indicated that reconfigurations of large-scale flow regimes can alter regional weather patterns due to shifts in storm tracks and associated eddy transports of heat, momentum, and vorticity. Conventional wisdom also suggests that high-impact weather events tend to occur during large-scale regime transitions. Motivated by these considerations, this research investigates relationships between large-scale regime transitions and Northeast precipitation in the cool season (November–April) from a statistical and synoptic perspective. In this study, a regime transition is defined as a two-standard-deviation change centered on zero in the North Atlantic Oscillation (NAO) index or Pacific/North American (PNA) pattern index over a seven-day period. To identify regime transitions, a 56-year database (1948–2003) of daily NAO and PNA indices was generated from the National Centers for Environmental Prediction (NCEP)–National Center for Atmospheric Research (NCAR) reanalysis dataset. A daily precipitation anomaly database for the Northeast was derived from the Unified Precipitation Dataset (UPD) for the same 56-year period. Key statistical results indicate that transitions from positive to negative NAO regimes and from negative to positive PNA regimes are associated with enhanced precipitation in the Northeast. Conversely, transitions from negative to positive NAO regimes and from positive to negative PNA regimes are associated with suppressed Northeast precipitation. Results also show that during periods ii surrounding major Northeast precipitation events in the cool season, the NAO index tends to decrease and the PNA index tends to increase. To interpret these relationships synoptically, composite analyses were created of cool-season regime transitions surrounding major precipitation events in the Northeast. The analyses suggest that synoptic-scale features are important in these types of large-scale regimes transitions. A positive-tonegative NAO regime transition (a weakening of the North Atlantic jet) surrounding a major Northeast precipitation event appears to be related to strong warm air advection in the western North Atlantic downstream of a surface low associated with the Northeast precipitation event. In the case of a negative-topositive PNA regime transition [an amplification of a trough (ridge) over eastern (western) North America] surrounding a major Northeast precipitation event, two synoptic-scale features appear to be important. One feature is persistent warm air advection that amplifies a ridge over western North America, and the other feature is a weak cold surge in the Northeast in the wake of the precipitation event that acts to precondition the atmosphere for a second, stronger cold surge over eastern North America. iii