Shala L. Thomas slthom2@emory.edu ________________________________________________________________________________ EDUCATION Doctor of Philosophy, Pharmacology Emory University, Atlanta, GA Doctoral Candidate, Cumulative GPA: 3.95 Emphasis of study: Cancer Pharmacology & Signal Transduction Expected graduation date: Fall 2008 2003-present Bachelor of Science, Biochemistry Xavier University of LA, New Orleans, LA 1999-2003 Cumulative GPA: 4.00, summa cum laude _____________________________________________________________________________________ RESEARCH EXPERIENCE Dissertation Research, Department of Pharmacology Emory School of Medicine 2003-present Investigating disruption of cell survival and proliferative pathways by curumin analogs as well as potential combination treatments for lung cancer; Haian Fu, PhD, Advisor Studying effects of the natural compound curcumin and novel curcumin analogs on the microtubule cytoskeleton; Paraskevi Giannakakou, PhD, Advisor Graduate Rotation, Department of Chemistry Emory University Synthesized and purified HIV drug analogs; Dennis Liotta, PhD, Advisor 2003 Senior Thesis Research, Pharmaceutical Sciences Xavier University of LA 2001-2003 Examined the effects of commonly used organophosphate pesticides on the endocrine system and hormone-receptor binding; Thomas Wiese, PhD, Advisor Summer Research Intern, Molecular Biology/Genetics U of Chicago, Chicago, IL 2002 Studied the process somatic hypermutation of antibody molecules important for host immune responses; Ursula Storb, MD, Advisor Summer Research Intern, Microbiology NYU School of Medicine, New York, NY 2001 Studied the structure and function relationship of the subunits of the SWI/SNF chromatin remodeling complex; Naoko Tanese, PhD, Advisor _____________________________________________________________________________ MEDICAL/SCIENCE COMMUNICATIONS MEDICAL WRITING Healtheva.com Medical forum writer focusing on basic and clinical cancer research Summarize recent medical research for registered physicans and scientists 2007-present TEACHING Principles of Pharmacology, Department of Pharmacology Emory University 2005 Peer instructor for the PROMISE postbaccalaureate program students Led weekly review sessions for seven students for introductory pharmacology material Frontiers in Pharmacology, Department of Pharmacology Emory University 2005 Teacher assistant for class concerning the breakthroughs and techniques in pharmacology Assisted in student grant writing and critiqued grant proposals PRESENTATIONS Thomas SL, Khuri F, Snyder JP, Liotta D, Fu H. Synergistic anticancer potential of the combination of p38 MAPK inhibition and EF24, a curcumin analog in A549 human lung cancer cells. AAAS/Packard Graduate Scholars Meeting. Washington, D.C. October, 2007. (poster), 2nd Annual NIH Graduate Student Festival. Bethesda, MD. October, 2007 (poster), AACR Frontiers in Cancer Prevention Conference. Philadelphia, PA. December 2007. (poster) Thomas SL, O’Brate A, Malik S, Sun, A, Liotta D, Snyder J, Giannakakou P. “Anti-HIF Mechanism of Curcumin and its Analog EF24”. American Association of Cancer Research National Meeting. Washington DC. April 1-5, 2006 (oral). Thomas SL, Malik S, Sun A, Liotta D, Snyder J, Giannakakou P. “Curcuminoids: An Investigation Behind the Anticancer Mechanism”. American Association of Cancer Research (AACR) National Meeting. Aneheim, CA. April 16-20, 2005 (poster) PUBLICATIONS Thomas SL, Zhao J, Khuri F, Snyder JP, Liotta D, Fu H. “Synergistic anticancer potential of the combination of p38 MAPK inhibition and EF24, a curcumin analog in A549 human lung cancer cells”. In preparation. Thomas SL, O’Brate AM, Zhong D, Zhou W, Snyder JP, Liotta D, Giannakakou P. “EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF1α”. In preparation. Kasinski A, Du Y, Thomas SL, Sun A, Khuri FR, Snyder J, Liotta D, Fu H. (2007) Inhibition of NFkB by a novel Curcumin Analogue. In preparation. Ganesh T, Yang C, Noris A, Glass T, Bane S, Ravindra R, Banerjee A, Metaferia B, Thomas SL, Giannakakou P, Alcaraz AA, Lakdawla AS, Snyder JP, Kingston DG. Evaluation of the Tubulin-Bound Paclitaxel Conformation: Synthesis, Biology and SAR Studies of C-3’ Bridged Paclitaxel Analogs. J Med Chem. 2007 Feb 22;50(4):713-25. Marcus AI, O’Brate AM, Buey RM, Zhou J, Thomas SL, Khuri FR, Andreu JM, Diaz F, Giannakakou P. “Farnesyltransferase Inhibitors reverse taxane resistance”. Cancer Res. 2006 Sep 1;280(12):8838-46. Marcus AI, Peters U, Thomas SL, Garrett S, Zelnak A, Kapoor T, Giannakakou P. “Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and sensitive cancer cells”. J Biol Chem. 2005 Mar 25;280(12):11569-77. ____________________________________________________________________________________ LEADERSHIP EXPERIENCE Student Representative, Pharamcology Program Executive Board 2006-present Parntership for Prescription Assistance Outreach Street Team 2004 Emory Black Graduate Student Association, Executive Board 2004-2007 ACS Student Affliate Chemistry Club, President 2002-2003 _____________________________________________________________________________________ AWARDS AND HONORS Drug Development & Pharmacogenomics Academy 2007 NIH National Graduate Student Festival 2007 Biotechnology Institute Minority and Indigenous Fellows Program 2006 Facilitating Academic Careers in Engineering and Science Fellowship 2005 American Association for Cancer Research Minority Scholar Travel Award 2005/2006 Emory Minority Graduate Fellowship 2003 Packard Foundation/American Assoc. for the Advancement of Science Graduate Fellowship 2003 American Chemical Society Local Section Senior Chemistry Major Award 2003 _____________________________________________________________________________________ PROFESSIONAL MEMBERSHIPS American Society of Pharmacology and Experimental Therapeutics 2006-present 2 American Association for Cancer Research 2005-2007 American Association for the Advancement of Science 2004-2005 _____________________________________________________________________________________ 3