Date of Document: 5/15/2012
Office Address: Medical College of Wisconsin
Human & Molecular Genetics Center
8701 Watertown Plank Road, HRC 5 th Floor, Rm. #H5160
Milwaukee, WI 53226
Phone: 414/456-4887
Fax: 414/456-6516
Email: jacob@mcw.edu
Place of Birth: Topeka, Kansas
Citizenship: U.S.A.
Major Research Interests:
1. Quantitative genetics
2. Genetic dissection of complex disease
3. Disease interaction/target organ damage
4.
Integrative physiology
5.
NextGen Sequencing and clinical applications
Board of Trustees:
Business Activities:
2009 – Present Alverno College
1997 – 2006
1997 – 2004
2006 – 2009
Founder and Chairman of the Board PhysioGenix, Inc.
Chief Executive Officer PhysioGenix, Inc
Founder and Board Member, PhysioGenix, Inc.
2011 – Present Founder and Board member, Primary Genetics
Patent Issued:
Rat Model of Diabetic Nephropathy. 650053 - 91657
Education:
1979 - 1983
1984 - 1989
B.S. (Biology)
Iowa State University
Ames, IA
Ph.D. (Pharmacology)
University of Iowa
Iowa City, IA
1

Postdoctoral Training and Fellowship Appointments:
1989 – 1991
1989 – 1992
1991 – 1992
Faculty Appointments (Including Secondary Appointments):
1992 - 1996
1996 – 1997
1996 – 2006
1997 – 2001
1999 - Present
1999 - Present
2001 - Present
2006 – Present
Hypertension Training Program
Harvard Medical School
Cambridge, MA
Whitehead Institute for Biomedical Research
Massachusetts Institute of Technology
Boston, MA
Cardiology
Stanford University
Stanford, CA
Department of Medicine
Harvard Medical School
Cambridge, MA
Department of Physiology
Medical College of Wisconsin
Milwaukee, WI
Department of Pediatrics
Children’s Hospital of Wisconsin
Milwaukee, WI
Department of Physiology
Medical College of Wisconsin
Milwaukee, WI
Medical College of Wisconsin
Milwaukee, WI
Medical College of Wisconsin
Milwaukee, WI
Milwaukee, WI
Milwaukee, WI
Department of Physiology
Medical College of Wisconsin
Department of Pediatrics
Children’s Hospital of Wisconsin
Human and Molecular Genetics Center
2

Administrative Appointments:
1993 – 1994
1999 - Present
2004 – 2009
2009 – Present
Cardiovascular Research Center Seminar Series
Massachusetts General Hospital
Boston, MA
Human and Molecular Genetics Center
Medical College of Wisconsin
Milwaukee, WI
Children’s Hospital of Wisconsin
Milwaukee, WI
Educational Administrative Positions:
1998 – 2000
Positional Cloning Course
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY
Department of Research
Children’s Hospital & Health System
Milwaukee, WI
1998 – 2004
Physiological Genetics Course
Department of Physiology
Medical College of Wisconsin
Milwaukee, WI
Hospital and Clinic Administrative Appointments:
1992 – 1996
Department of Medicine
Massachusetts General Hospital
Boston, MA
Awards and Honors:
1991 Merck, Sharpe and Dohme Travel Award for Outstanding
Cardiovascular Research
1991 Sokol Post Doctoral Fellowship Award, Whitehead Institute for
Biomedical Research
1998 Elected Fellow in the Council for High Blood Pressure
1999 American Physiological Society, Bowditch Award and Lecturer (Young
Investigator Award)
1999 Warren P. Knowles Chair of Genetics
2007 A. Ross McIntyre Award, University of Nebraska
2009 Golden Medal, Jessenius Faculty of Medicine in Martin, Comenius
University in Bratislava.
3

2011 2011 Milwaukee Regional Research Forum’s T. Michael Bolger Award.
Milwaukee WI.
2011 BizTimes.com ‘Grand Achievement Award’. Milwaukee WI.
2012 Scripps Genomic Medicine Award, 2012. Scripps Translational Science
Institute, La Jolla Ca
Memberships and Professional Scientific Societies:
American Association for the Advancement of Science
American Physiological Society
American Society of Human Genetics
American Society of Nephrology
Genetics Society of America
International Mammalian Genome Society
International Society of Nephrology
Editorial Boards:
1995 - 1997
1996 – 2004
1997 - 1997
1997 – 2004
1999 – 2005
American Journal of Physiology
Genome Research
American Heart Association Council for High Blood Pressure
Mammalian Genome
Physiological Genomics
Local/Appointed Leadership and Committee Positions:
1986 – 1987
1999 – Present
1999
2000
2000
2000
2000 – Present
2000
2000
2001 – Present
2001
2001 – Present
2001
2002 – 2007
2003 – 2006
2004 – 2008
2006 – 2008
2006 – 2008
2006 – 2008
Faculty Search Committee
Department of Pharmacology
University of Iowa
Iowa City, IA
Executive Faculty Committee
Human Research Review Committee
Animal Research Center Faculty Advisory Committee
Arrayer Executive Faculty Committee
Barrier Facility Advisory Committee
Cancer Center Advisory Committee
Medical Scientist Training Program Committee
Strategic Issues Group Committee
Cancer Center Director Search Committee
Educational Retreat Committee
Research Strategy Advisory Committee
Stem Cell Research Committee
BiCore Advisory Committee
Physiological Genomics Publications Committee Associate
Editor
Children’s Research Institute Scientific Advisory and
Policy Committee
Executive Steering Committee
Biomedical Research Advisory Committee
Strategic Planning Committee
4

2008 – Present
2009 – Present
2011 – 2014
2011 – Present
2011 – Present
2011 – Present
1990
1993
1994
1995 – 2005
1995 - 1995
1995
1996
1996
1996 – 1997
1996 – 2000
1996 – 1998
1996 – 1997
Dean’s Advisory Committee
Pediatric Executive Committee
Dean’s Appointee to the Faculty Career Development
Committee
MCW Centers Work Group
MCW Search Committee for the Director of
Cardiovascular Center and Divisional Chief of Cardiology
MCW Search Committee for the Chair for the Dept of
Pediatrics.
National and Regional Elected/Appointed Leadership and Committee Positions:
National Heart, Lung and Blood Institute
Bethesda, MD
Gene Polymorphism in Hypertension
American Heart Association Council for High Blood Pressure
Dallas, TX
International Society of Hypertension
Melbourne, Australia
Mammalian Genotyping Center
National Heart, Lung and Blood Institute
Bethesda, MD
Canadian Medical Council
Montreal, Canada
National Institute of Alcohol Addiction and Abuse
Bethesda, MD
Molecular Biology of Hypertension
International Society of Hypertension
Glasgow, Scotland
International Society of Hypertension
Glasgow, Scotland
Medical College of Wisconsin
Milwaukee, WI
New York, NY
Department of Pediatrics
Milwaukee, WI
Medical College of Wisconsin
International Society of Hypertension 2000
American Society of Hypertension
5

1996
1997
1997 – 1998
1997
1997
1997 – 1998
1998
1998
1998
1998
1998
1998
Banbury Conference
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY
Genomics to Physiology and Beyond
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY
Breakfast Workshop
Ninth International Symposium on SHR and Cardiovascular
Genetics
Montreal, Canada
Digestive Disease Center
Medical College of Wisconsin
Milwaukee, WI
Genetic Susceptibility to Target Organ Damage in High
Blood Pressure
National Heart, Lung and Blood Institute
Bethesda, MD
Program on Selected Advances in Cell and Molecular Biology,
Foundation for Advanced Education in the Sciences
National Institutes of Health
Bethesda, MD
International Rat Genetics Meeting
Hannover, Germany
Merck
Scottsdale, AZ
In Focus Program/FASEB
American Physiological Society
San Francisco, CA
Genome Mapping, Sequencing and Biology
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY
Mouse Genome Priorities Setting Meeting
National Human Genome Research Institute
Bethesda, MD
Human Genome Planning Meeting
National Human Genome Research Institute
Bethesda, MD
National Human Genome Research Institute
Bethesda, MD
6

1998
1998
1998
1998
1998
1998
1998
1998 – 2005
1999
1999 – 2000
1999 – 2000
2000 – 2004
2001
Workshop on Strategies for Identification of Nephro- pathy Susceptibility Genes
National Institute of Diabetes, Digestive and Kidney
Diseases
Bethesda, MD
Program for the 12th International Workshop on
Alloantigenic Systems in the Rat
Halifax, Nova Scotia
Genetic Basis of Variability in the Progression and
Outcome of Heart, Lung, and Blood Diseases
National Heart, Lung and Blood Institute
Bethesda, MD
Rat Model Repository Meeting
National Heart, Lung and Blood Institute
National Human Genome Research Institute
Bethesda, MD
Model Organisms Databases Workshop
National Heart, Lung and Blood Institute
Bethesda, MD
Polycystic Kidney Disease
National Institute of Diabetes, Digestive and Kidney Diseases
Bethesda, MD
National Human Genome Research Institute
Bethesda, MD
Physiological Genomics and Rat Models
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY
National Institute of Digestive Disorders and Kidney Diseases
Bethesda, MD
Animal Resource Center
Medical College of Wisconsin
Milwaukee, WI
ISH 2000 Genetics Satellite Symposium
Chicago, IL
PGA Coordinating Committee
Program for Genomic Applications
National Heart, Lung and Blood Institute
Bethesda, MD
7

2001 – 2004
2002
2002
2002
2002
2003
2003
2003
2004 – Present
2005
2005 – 2008
2006
2005
University of Missouri
Columbia, MO
US Genome Sequencing Program
National Human Genome Research Institute
Bethesda, MD
Genemill 2002
University of Liege
Brussels, Belgium
National Human Genome Research Institute
The Future of Genomics Meeting
Airlie, VA
National Institute of Diabetes, Digestive and Kidney Diseases
Division of Diabetes, Endocrinology and Metabolic Diseases
Bethesda, MD.
National Human Genome Research Institute
SAP/PI Meeting
Bethesda, MD
National Institute of Health, National Human Genome
Research Institute
Human Genome Database Workshop
Bethesda, MD
Review Committee
Bethesda, MD
Member
Mammalian Genetics Study Section,
National Institute of Health
National Heart, Lung and Blood Institute
Biomedical Information Science and Technology Initiative
Bethesda, MD
Vialactia Biosciences
Auckland, New Zealand
Center for Scientific Review
Genetics of Health & Disease Study Section
National Institutes of Health
Bethesda, MD
Mammalian Gene Collection External Steering Committee
National Human Genome Research Institute
Bethesda, MD
National Heart, Lung & Blood Institute – Strategic Planning
Committee
8

2006 – 2011
2006 -- 2011
2008 - 2011
International Evaluation of Research Groups
Max Delbruck Center for Molecular Medicine
Berlin-Buch, Germany
Genetics of Health & Disease Study Section
National Institutes of Health
Bethesda, MD
National Institute of General Medical Sciences
National Institutes of Health
Pharmacogenetics Network
Bethesda, MD
2011
1981 - 1983
1984 - 1984
1984 - 1989
1992 - 1996
1996 - 1998
1996 – 1998
Self Report of Teaching:
1983
1986 – 1988
The TMJ Association
Milwaukee WI
External Evaluation of MDC Research Groups, Guest Groups and ECRC Groups. March 6-8, 2012. Max Delbruck Center for Molecular Medicine (MDC) Berlin-Buch.
Other Professional Positions and Major Visiting Appointments:
Abbott Laboratories
Abbott Park, IL
Abbott Laboratories
Abbott Park, IL
University of Iowa
Iowa City, IA
Whitehead Institute for Biomedical Research
Massachusetts Institute of Technology
Boston, MA
Massachusetts General Hospital
Boston, MA
Harvard Medical School
Cambridge, MA
Biology
Iowa State University
Ames, IA
9

1995
1996
1996
1988 - 1989
1989
1990 - 1992
1993
1993
1994 - 1996
1994
1994 – 1996
1993 - 1995
Drugs, Their Nature, Action and Use
University of Iowa
Iowa City, IA
Medical Pharmacology
University of Iowa
Iowa City, IA
Undergraduate student
Harvard Medical School
Cambridge, MA
Undergraduate Research Opportunities Program - Biology
Massachusetts Institute of Technology
Cambridge, MA
Graduate Course in Molecular Endocrinology
Karolinska Institute
Stockholm, Sweden
Genetics Course for Medical Students
Harvard Medical School
Cambridge, MA
Pro-Tech high school students
Massachusetts General Hospital
Boston, MA
ABI Linkage Workshop
National Institutes of Health
Bethesda, MD
Department of Genetics
Harvard Medical School
Cambridge, MA
For Anna Pettersson
Karolinska Institute
Stockholm, Sweden
Harvard Medical School
Cambridge, MA
For David Stec
Medical College of Wisconsin
Milwaukee, WI
For Matt Sunvald
Department of Human Genetics
University of Uppsala
Uppsala, Sweden
10

Trainees:
Visiting Scientists:
Post Doctoral Fellows:
1995 – 1998
1998 – 2000
1999 – 2000
2008
1992 – 1993
1992 – 1995
1992 – 1995
1993 – 1996
1993 – 1996
1993 – 1996
1996 - 1998
1998 - 2000
1998 – Present
1998 – 2004
2001 – 2008
2002
2004
2010
For Christina Kendziorski
Department of Mathematics
Marquette University
Milwaukee, WI
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY
Physiological Genetics
Medical College of Wisconsin
Milwaukee, WI
Genetic Approaches to Heart, Lung and Blood Diseases
National Heart, Lung and Blood Institute
Bar Harbor, ME
Microbiology Techniques Course
Milwaukee, WI
The Jackson Laboratory 43 rd
Bar Harbor, ME
Annual Short Course
Curriculum of the Post-Graduate Master of Science & Ph.D.
Scientific Studies, Basic & Clinical Medical Sciences
Clinical Physiology/Physiological Genomics
University of Split School of Medicine
Split, Croatia
The Future of Genomic Medicine IV
“Bringing genomic sequence into the clinic: just another lab value?”
Scripps Translational Science Institute, San Diego CA.
Masahide Shiozawa, M.D., Ph.D.
Yasuhiro Kita, Ph.D.
Diana Maas, M.D.
Hairong Wang, Ph.D.
Pei-wen Chiang, Ph.D.
Maria R. Trolliet, Ph.D.
Jason S. Simon, Ph.D.
Sarah Weksler-Zangen, Ph.D.
Ela Knapik, M.D.
George Koike, M.D., Ph.D.
11

Research Fellows:
Research Scientists:
1996 – 1999
1996 – 2000
1996 – 1997
1996 – 1997
1998 – 2000
1999 – 2001
2000 – 2004
2001 – 2001
2001 – 2002
2001 – 2004
2002 – 2004
2002 – 2004
2002 – 2005
2004 – 2007
2006 – 2009
2006 – 2007
Monika Stoll, Ph.D.
Ulrich Broeckel, M.D.
Anne Kwitek-Black, Ph.D.
Jian Jiang, Ph.D.
Simon Twigger, Ph.D.
Pierre Dumas, Ph.D.
Michael Jensen-Seaman, Ph.D.
Thomas E. Feroah, Ph.D.
Vicky Grumman, D.V.M.
Carol Moreno-Quinn, M.D., Ph.D.
Andrea Baessler, M.D.
Marcus Fischer, M.D.
Marijo Bilusic, M.D.
Leah Solberg, Ph.D.
Aron Geurts, Ph.D.
2006 – 2008
2006 – 2008
2009 – 2009
Nancy Schlick, Ph.D.
Artur Rangel-Filho, M.D., Ph.D.
Tatjana Adamovic, Ph.D.
Vidya Rao, Ph.D.
2009 – Present Sheng Yang, Ph.D.
2010 – Present Mike Flister, Ph.D.
2010 – 2012 Caitlin O’Meara, Ph.D.
1997 – 1999 Vishwanatha Nadig, M.D.
2008 – Present Hiang Xu, Ph.D.
2008 – 2010 Elizabeth Worthey, Ph.D.
Graduate Students:
1993 – 1995
1994 – 1995
1995 – 1996
1996 – 2001
1997 – 1998
2000 – 2006
2000 – 2006
Anna Pettersson, Ph.D.
Michael McLaughlin, M.D.
Brendan Innes (visiting for 9 months)
Marcelo Nobrega, M.D., Ph.D.
Vishwanatha Nadig, M.D.
Artur Rangel-Filho, M.D., Ph.D.
Nancy Schlick, Ph.D.
Marcus Corat 2001 – 2002
2001 – 2002
2001 – 2002
2002 – 2006
Patricia Corat
Danilo Carlos
Michelle Lutz, M.D., Ph.D.
2007 -- Present Caitlin O’Meara
2007 – Present Allison Sarkis
2008 – Present Sheila Reagles
2009 – Present Sasha Zheng (MSTP)
2010 – Present Bryce Schuler (MSTP)
12

Medical Students:
Undergraduates:
2010 – Present
1995 – 1995
Nan Cher (Florence) Yeo
Michael G. McLaughlin
2004 (Summer) Matthew Weston
2004 (Summer) Barbara Meinecke
2008 (Summer) Deepak Rai
2010 - 2011
2010 – 2011
Brennan Decker
Ameen Salahudeen
1990 (Summer) Jerome McDonald
1990 – 1992 Ruth Bunker
1996 (Summer) Tamara Taylor
1996 – 1997
1997 – 1998
Atta Behfar-Rad
Obinna Menome
1998 (Summer) Sahera Dirajlal
1998 (Summer) Delisa Atkins
1998 (Summer) Carla Fluentes
1999 (Summer) Karen L. Stark
2000 – 2001 Beth Konicek
2000 (Summer) Stacy Johnson
2001 (Summer) Mark Biagtan
2001 (Summer) Lisa Bosnjak
2002 (Summer) Ryan Gore
2002 (Summer) Lisa Bosnjak
2003 (Summer) Christopher Janowak
2003 (Summer) Elizabeth Oberg
2003 (Summer) Sarah Roach
2004 (Summer) Jozef Lazar, Jr.
2005 (Summer) Jozef Lazar, Jr.
2005 (Summer) Sarah Kahn
2006 (Summer) Marielle Discipulo
2006 (Summer) Michael Soule
High School Students:
2006 (Summer) Jozef Lazar, Jr.
2007 (Summer) Erin Mathewson
2007 (Summer) Jozef Lazar, Jr.
2008 (Summer/Fall) Ivana Micanovic
2009 (Summer) Barthalomew Sillah
1994 – 1995 Cory Futrell
1995 (Summer) Luc Pierre
1996 (Summer) Mathew Stein
1996 (Summer) Nathan Pedretti
1997 (Summer) Joshua Cohen
1997 (Summer) Rami Peltz
1999 (Summer) Jeremiah P. Holzbauer
13

1999 – 2001 Nasuh Malas
1999 – 2000 James Wu
2001 – 2002 Jennifer Holland
2001 (Summer) Michelle Lombard
2001 (Summer) Jacob Frautschi
2001 – 2003 Wassim Malas
2002 – 2003 Jozef Lazar, Jr.
2002 (Summer) Andrew Zaeske
2002 (Summer) Joseph Johnny
2003 (Summer) Joseph Haines
2003 – 2005 Nour Malas
2004 (Summer) Christopher Gore
2004 – 2005 Rachel Theisen
2005 – 2007 Max Machotka
Awards Earned by Members of the Jacob Lab:
1995 Merck, Sharpe & Dohme Travel Award for Outstanding Cardiovascular Research
1995 Trainee Investigator Award for Excellence in Scientific Research
1996 Young Investigator Travel Grant (International Society of Hypertension Meeting)
Previous Support for Former Lab Members:
 Medical Research Council of Sweden
 The Stanley J. Sarnoff Endowment of Cardiovascular Science, Inc.
 Florida American Heart Association
 American Heart Association
 NIH, NRSA
 Deutsche Forschungsgemeinschaft (DFG), Germany
 Deutsche Forschungsgemeinschaft (DFG), Germany
 NIH, NRSA
 Deutsche Forschungsgemeinschaft (DFG), Germany
 Deutsche Forschungsgemeinschaft (DFG), Germany
 American Physiological Society Fellowship Grant
14

Research Grants, Contracts, Awards & Projects:
Completed:
1992 - 1996
1993 - 1996
1993 - 1997
1994 - 1996
1994 - 1996
1995 - 2005
1996 - 1999
1996 - 2000
1996 - 2006
1997 - 1998
1997 - 2003
1997 - 2005
1997 - 2002
1998 - 2001
1999 – 2000
Bristol-Myers Squibb
Genetics of Hypertension and Renal Failure in FH-Rats
PI
Bristol-Myers Squibb
Human Polygenic Disorders
PI
National Institutes of Health
Genetic Dissection of Diabetes in Man and the BB Rat
PI
National Institutes of Health
Construction of a Genetic Linkage Map of Zebrafish
PI (Grant PI transferred to Dr. Mark Fishman, 1996-1999)
National Institute of Health
Genetic Basis of Stroke in SHRSP
Subcontract
National Institute of Health
Genetic Determinants of High Blood Pressure: Rat Mapping
Center
PI
National Institute of Health
Genetic Map and Large Insert Library for the Rat Genome
Co-PI
National Institute of Health
Fawn Hooded Rat: Model for ESRD
PI
National Institute of Health
Rat Genetic Mapping Center, SCOR: Molecular Genetics of
Hypertension
PI
National Heart Lung and Blood Institute Genotyping Service
Genetics of Obesity (>1,000,000 genotypes)
Co-PI
National Heart Lung and Blood Institute Genotyping Service
Genetics of Myocardial Infarction (>1,000,000 genotypes)
Co-PI
National Heart, Lung and Blood Institute
Genetic Control of BB rat Autoimmunity
Subcontract, Co-PI
National Institute of Health
Construction of Unigen Style Rat Map Using Rat RH’s
PI
National Institute of Health
Genetic Dissection of Ventilatory Traits
PI, Subcontract
Genome Research Institute
Consomic Animals for Rapid Generation of Single Gene
Models of Complex Disease
15

2000 - 2009
2005 - 2009
2007 – 2009
2008 - 2009
2000 - 2004
2000 - 2005
2000 - 2005
2001 - 2005
2004 – 2007
2006 – 2007
2006 – 2007
2006 – 2008
2006 – 2008
PI
National Institute of Health
Genetic Basis of Myocardial Infarction in Humans
Co-PI
National Heart, Lung and Blood Institute
Genetic Determinates: Rat Mapping Center
PI
National Institute of Health
HyperGEN: Genetics of Left Ventricular Hypertrophy, NHLBI
Subcontract, Co-PI
National Institute of Health
Physiological Genomics of Hypertensive Renal Disease
PI
United States-Israel Bi-National Science Foundation (BSF)
Study of Differential Gene Expression in the Kidneys of the
Sabra Rat
PI
Dillon Trust
Family Based Genetic Analysis of Genes Related to End
Stage Renal Disease
PI
Medical College of Wisconsin; Children’s Research Institute
IMI: Children’s Research Institute – Genetics Initiative
PI
Medical College of Wisconsin/Children’s Research Institute
Development of an Animal Model of ARPKD for Therapy
Testing
PI
Medical College of Wisconsin; Advancing a Healthier
Wisconsin
MCW Genetic Analysis Initiative for Individualized Medicine
PI
National Institute of Health
Program for Genomic Applications (PGA)
PI
$25,549,623
National Institutes of Health
PGA Supplement (Knockout Rats for Physiological Genomics)
PI
American Physiological Society
Validation of Rab38 as a Genetic Component of End-Stage
Renal Disease in the Fawn Hooded Hypertensive Rat
Sponsor – Post Doctoral Fellowship
Medical College of Wisconsin; Biotechnology and
Bioengineering Center
Development of Genomic Sequencing in Clinical Practice
PI
16

Current:
2008 - 2009
2008 - 2009
2007 - 2011
2005 – 2010
2008 - 2011
2008 - 2011
2005 - 2014
2006 – 2016
2007 - 2012
2009 – 2012
2009 - 2012
Dept. of Health & Human Services, Health Resources &
Service Administration (HSRA)
Genomic Sequencer
PI
Sigma Aldrich
Genome Modification in the Rat Using Zinc Finger Nucleases
PI
National Institutes of Health
5R01HL069321-08.
Physiological Genomics of Hypertensive
Renal Disease
PI
National Institute of Health
Genetic control of BB Rat Autoimmunity
Collaborator (as needed)
Advancing a Healthier Wisconsin
Systems Biology Program in Cardiovascular Disease
PI
National Institutes of Health
5R21RR025187-02.Transposon Mutagenesis for Modeling
Complex Human Disease in Rats
PI
National Institute of Health
5R01HL064541-11. Rat Genome Database
PI
$43,241,585
National Institute of Health
5P01HL082798-06A1.
Genetic & Physiological Basis of Salt-
Induced Hypertension
PI (Genomics Core)
National Institutes of Health
IP50DK079306-02. Integrative Biology of Childhood Kidney
Disease
PI (Genomics Core)
National Institutes of Health
1RC2HL101681-02.
Mechanistic characterization of genes for hypertension and renal disease
PI
European Union
Centre of Translational Medicine
Collaborator
17

2009 – 2013
2010 – 2015
2010 – 2015
National Institutes of Health
1R01HL089930-01A2.
Genetic and Cellular Basis of
Resistance/Sensitivity to Myocardial Ischemia
European Union Euratrans. FP7 Large Scale Collaborative
Project
Euratrans European Commission (Funding Agency)
Co-PI
National Institutes of Health
5UL1RR031973-02
Clinical and Translational Science Award (Bioinformatics
Component)
Co-PI
Pending
2012 – 2017
2012 - 2017
National Institutes of Health
1R01OD011704-01
Genome Variation: Defining Impact in Matched Sibling
Marrow Transplant for AML
PI
National Institues of Health
1R24HL114474-01
Resources for translating GWAS genes to mechanism and function
PI
Submitted/Not Funded:
2009 – 2015
2009 – 2010
2009 – 2011
2009 – 2011
National Institutes of Health
Genetics of Obstructive Anatomic Malformation in Congenital
Heart Disease
PI
Wellcome Trust
Wisconsin Genomics Initiative
Co-PI
National Institutes of Health
Generating a resource of germline-competent stem cells from widely used rat strains
PI
National Institutes of Health
18

2009 – 2011
2009 – 2010
2009 – 2011
2010 – 2015
2011 – 2015
2011 – 2016
2012 - 2017
2012 - 2017
GWAS for TMJD and Associated Chronic Pain Phenotypes
Co-PI
National Institutes of Health
Next Steps in Gene Discovery: The Wisconsin Genomics
Initiative
Co-PI
National Institutes of Health
Supplement for Physiological Genomics of Hypertensive renal disease
PI
United States – Israel Bidirectional Science Foundation
Genomics of Rare Diseases in Children
Co-PI
National Institutes of Health (T32)
Translational genetics of diabetes, obesity and the metabolic syndrome (TG-DOMS)
PI
National Institutes of Health
1RO1HL111234
Mechanistic characterization of genes for pulmonary function
Co-I
National Institues of Health
2R01HL069321-09
Identification of Genes & Gene Networks for Renal Disease
PI
National Institutes of Health
1UO1HG006506
Advancing Genomic Sequence to a Clinical Laboratory Assay.
PI
National Institues of Health
1R01HL114713-01
Defining the genetic structure of hypertension through multiple strain sequencing
PI
Invited Lectures/Workshops/Presentations/Site Visits:
1992
1992
University of Alabama, Vascular Biology and Hypertension Research Retreat,
Birmingham, AL.
Johns Hopkins Hospital, Division of Neuroanesthesia, Baltimore, MD.
19

1995
1995
1995
1995
1995
1996
1996
1996
1996
1996
1996
1996
1996
1993
1993
1993
1994
1994
1994
1994
1994
1994
1995
1993
1993
1993
1993
1993
1993
1996
1997
1997
1997
1997
1997
1997
1997
1997
1997
1997
1997
Columbia University, New York, NY.
Albany Medical College, Department of Pharmacology and Toxicology, Albany,
NY.
Mount Sinai, Department of Pediatric Cardiology and Human Genetics,
Milwaukee, WI.
Centre de Recherche Hotel-Dieu de Montreal, Canada.
Medical College of Wisconsin, Department of Physiology, Milwaukee, WI.
Rhône-Poulenc Rorer, Department of Cardiovascular Pharmacology, Paris,
France.
Massachusetts General Hospital, Department of Cardiology, Boston, MA.
Henry Ford Hospital, Hypertension and Vascular Research Division, Detroit, MI.
Research Genetics, Huntsville, AL.
Massachusetts General Hospital, Research Finance, Boston, MA.
University of Regensburg, Department of Medicine, Medizinische Klink II,
Munich, Germany.
Millennium Pharmaceuticals, Cambridge, MA.
Baxter, Renal Division, North Chicago, IL.
National Heart Institute, São Paulo, Brazil.
University of São Paulo, Department of Physiology, Sao Paulo, Brazil.
Bowman Gray Medical School, Nephrology Department, Wake Forest, North
Carolina.
Emory University School of Medicine, Renal Unit, Atlanta, GA.
Inter-American Society of Hypertension, Montreal, Canada.
American Society of Nephrology, San Diego, CA.
University of Montreal, Montreal, Canada.
Centre de Recherche Hotel-Dieu de Montreal, Montreal, Canada.
Baylor College of Medicine, Division of Endocrinology, Houston, TX.
Ciba Pharmaceuticals, Basel, Switzerland.
Massachusetts General Hospital, Reproductive Endocrine, Boston, MA.
INSERM Unit 47, Paris, France.
Sequana Therapeutics, San Diego, CA.
Research Genetics, Huntsville, AL.
Synthelabo Recherche, Department de Recherche Cardiovasculaire, Paris,
France.
National Public Health Institute, Department of Human Genetics, Helsinki,
Finland.
University of Uppsala, Department of Medical Genetics, Uppsala, Sweden.
Incyte Pharmaceuticals, Palo Alto, CA.
Marquette University, Biomedical Engineering Department, Milwaukee, WI.
The Congress of Molecular Medicine, International Congress Center, Berlin,
Germany.
American Society of Hypertension, Twelfth Scientific Meeting, San Francisco,
CA.
Genetics of Diabetes Satellite Meeting, Ystad, Sweden.
Genome Therapeutics, Boston, MA.
Gemini Research, Cambridge, UK.
Thirty-Second Annual MCW/Marquette Medical Alumni Association Clinical
Conference, Palm Springs, CA.
Marshfield Clinic, Marshfield, WI.
Parke-Davis Pharmaceutical Research, Ann Arbor, MI.
American Society of Nephrology, San Antonio, TX.
20

1999
1999
1999
1999
1999
1999
2000
2000
2000
2000
2000
2000
2000
1998
1998
1998
1998
1999
1999
1999
1999
1997
1997
1998
1998
1998
1998
1998
2000
2000
2000
2000
2000
2000
2000
2000
2000
2000
Banyu Institute, Tsukuba, Japan.
Roche/Jackson Laboratory, Palo Alto, CA.
Cambridge Healthtech, Functional Genomics, San Diego, CA.
Gordon Conference, Angiotensin II, San Marino del Mar, CA.
Pfizer Canada, Consultants Meeting, West Palm Beach, FL.
Incyte Pharmaceuticals, Palo Alto, CA.
Seventeenth Scientific Meeting of the International Society of Hypertension,
Amsterdam, The Netherlands.
Parke-Davis Pharmaceutical Research, Ann Arbor, MI.
Parke-Davis Molecular Genetics Laboratories, Alameda, CA.
Fifty-Eighth Annual American Diabetes Association, Chicago, IL.
Merck Research Laboratories, West Point, PA.
Cardiovascular Genetics, Cambridge Healthtech, Orlando, FL.
Rat Model Priority Meeting, Washington, DC.
University of Virginia School of Medicine, Cardiovascular Research Center
Seminar Series, Charlottesville, VA.
FASEB, “Genetic Mechanisms Determining the Role of the Kidney in the
Pathogenesis of Hypertension,” Washington, DC.
Joslin Diabetes Center, Boston, MA.
Mouse Genome Database Project, Bar Harbor, ME.
International Society of Hypertension in Blacks, Toronto, Ontario.
Eleventh International Genome Sequencing and Analysis Conference, Miami
Beach, FL.
University of Rochester, Rochester, NY.
CuraGen Corporation, New Haven, CT.
Second International Cardiovascular Genomics, Miami, FL.
Incyte Pharmaceuticals, Palo Alto, CA.
Cold Spring Harbor Laboratory, Genome Sequencing and Biology Meeting, Cold
Spring Harbor, NY.
Experimental Biology 2000, San Diego, CA.
National Heart, Lung and Blood Institute Committee Management Service
Center, Bethesda, MD.
University of California Los Angeles Medical Center, ACCESS Seminar, Los
Angeles, CA.
The 13th International Workshop on Genetic Systems in the Rat, Goteborg,
Sweden.
Merck Research Laboratory, Philadelphia, PA.
TOPS International Meeting, San Antonio, TX.
The Jackson Laboratory, “Mouse Initiatives II – Modeling of the Human
Genome and Disease,” Bar Harbor, ME.
DOE Human Genome Program Meeting, “Which Organism To Sequence,” San
Francisco, CA.
Twenty-Seventh International Conference on Animal Genetics, Minneapolis, MN
Excellence in Human Genetics Lecture Series, “In Search of Hypertension
Genes Using Rats and Humans,” Dallas, TX.
American Society of Nephrology, Toronto, Canada.
Genetics of Hypertension, “Approaches, Paradigms, Impact,” Porto Cervo,
Sardinia, Italy.
Fourteenth International Mouse Genome Conference, Tokyo, Japan.
Approaches to Integrative Physiology, Worcestershire, London.
21

2001
2001
2001
2001
2001
2001
2001
2001
2000
2001
2001
2001
2001
2001
2001
2001
2001
2001
2001
2001
2001
2002
2002
2002
2002
Fifty-Fourth Annual Fall Conference and Scientific Sessions of the Council for
High Blood Pressure Research, Washington, DC.
Rat Functional Genomics Meeting, Washington, DC.
Association of Anatomy, Cell Biology, Neurobiology Chairpersons Annual
Meeting, Los Cabos, Mexico.
Medical College of Wisconsin, Bioethics Center, “The Brave New Genetic
World,” Milwaukee, WI.
FASEB Conference, “Physiological Genomics: Gene Profiling, Regulation and
Analysis,” Orlando, FL.
University of Cincinnati, Children’s Hospital Medical Center, “Functional
Genomics: From Rat to Man,” Cincinnati, OH.
Milwaukee Biotechnology Interest Group, “After the Genomic Project: Real
Biotech Possibilities,” Milwaukee, WI.
Charles River Laboratories, “Selection of Microsatellites for Characterizing and
Monitoring Outbred Stocks of Rats,” Wilmington, MA.
Medical College of Wisconsin, Summer Program for Undergraduate Research
(SPUR), “From Sequence to Biology,” Milwaukee, WI.
American Thoracic Society, “C7-Genetic Dissection of Respiratory Traits,” San
Francisco, CA.
Medical College of Wisconsin, Plastic Surgery Research Council, “Sequence
Based Biology: A Clinical Interest?” Milwaukee, WI.
University of Wisconsin-Madison, Midwest Physiological Society, “Physiological
Genomics: Strategies for Understanding Gene Function,” Madison, WI.
Children’s Hospital of Wisconsin, Pediatric Grand Rounds, “Sequence Based
Biology - Medicine for the 21 st Century,” Milwaukee, WI.
Waukesha Memorial Hospital, Oncology Review Board, “Using Genomics to Go from Benchside to Bedside,” Waukesha, WI.
Michigan State University, GE Molecular Imaging Workshop, “Sequence Based
Biology: Microarray to Bedside,” East Lansing, MI.
Merck Research Laboratories, “Comparative Genomics for Renal Disease
Targets,” West Point, PA.
IV International Symposium – Vasoactive Peptides, “Adopting Genomic Tools for Physiological Studies,” Bel Horizonte, Minas Gerais, Brazil.
American Heart Association 55 th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research, “Comparative Genomics: A
Tool for Gene Discovery,” Chicago, IL.
Medical College of Wisconsin, Center for the Study of Bioethics, Midwest Ethics
Committee Network, “Over View of Genetics,” Milwaukee, WI.
Medical College of Wisconsin, Young Presidents Organization, “Beyond 2001:
How Genetics Will Change Your Life,” Milwaukee, WI.
Columbia Hospital, Medical Grand Rounds, “Molecular Genetics and Application to Clinical Medicine,” Milwaukee, WI.
University of Regensburg, “Identifying Genes for Coronary Artery Disease,”
Munich, Germany.
Cleveland Clinic Foundation, “Functional Genomics and Applications to
Cardiovascular Disease,” Cleveland, OH.
University of Chicago, “Comparative Genomics for SNPs, Chips and Disease
Genes,” Chicago, IL.
American Physiological Society, “Physiological Genomics: From Rat to Human,”
San Francisco, CA.
22

2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2002
2003
2003
2003
2003
2003
2003
Transcriptome 2002: From Functional Genomics to Systems Biology, “System
Biology, from Genome to Physiology,” Seattle, Washington.
St. Mary’s Hospital, Grand Rounds, “Molecular Genetics and Application to
Clinical Medicine,” Milwaukee, WI.
National Human Genome Research Institute, National Institute of Health,
“Application of Functional Genomics to Cardiovascular Disease,” Bethesda,
MD.
Medical College of Wisconsin, North Central Chapter of the Health Physics
Society, Milwaukee, WI.
University of Texas, Physiology at the UTHSC, “Physiological Genomics in
Sequencing World,” San Antonio, TX.
University of Michigan, “Systems Biology: Rat to Man,” Ann Arbor, MI.
Medical College of Wisconsin, Bioinformatics Research Center Seminar Series,
“Linking Physiology, genomics and disease,” Milwaukee, WI.
Baylor College of Medicine, “Rat Genome Sequence and Physiological
Genomics,” Houston, TX.
University of Wisconsin-Madison, Wisconsin Technology Council, “Systems
Biology and Drug Discovery,” Madison, WI.
American Thoracic Society, “Systems Biology and Functional Genomics for
Heart, Lung and Blood Disorder,” Atlanta, GA.
Endocrine Society, “Systems Biology Approaches to the Genetics of
Hypertension and Insulin Resistance,” San Francisco, CA.
Eighth International Sleep and Breathing Symposium, “Genetic Models of
Cardiovascular Disease in Rats,” Reykjavik, Iceland.
Fidelity Foundation Enabling Technologies for Alzheimer’s Disease Research II,
Bar Harbor, ME.
University of Tennessee, “Hypertension Research Using Systems Biology,”
Memphis, TN.
Cambridge Healthtech Institute, Genomic Animal Models, “Genetic Models for
ADME, Disease Characterization and Efficacy Testing,” Boston, MA.
XVI Congreso LatinoAmericano De Patologia Clinica, “Pharmacogenomics
Plenary Session,” Acapulco, Mexico.
Brigham and Women’s Hospital Molecular Medicine Seminar Series, “System
Biology for Understanding End Organ Disease,” Cambridge, MA.
Abbott Laboratories, “Systems Biology for Understanding End Organ Disease,”
Abbott Park, IL.
Charles River Laboratories, “Novel Rat Models for Drug Discovery,” Strasbourg,
France.
Louisiana State University, “Pharmacology in a Sequence Based World,” New
Orleans, LA.
University of Minnesota, “Genetics and Genomics of Complex Disease,” Duluth,
MN.
Harvard Medical School/Framingham Heart Study, National Heart, Lung and
Blood Institute, “High throughput rat physiology,” Cambridge, MA.
Federation of American Societies for Experimental Biology, “Rat Models of
HLBS,” San Diego, CA.
Association of University of Anesthesiologists, “Genetics, Genomics and Clinical
Medicine,” Milwaukee, WI.
Center for Research on Environmental Disease Symposium, “Genetic Models for
Drug Discovery and Toxicology,” Austin, TX.
23

2003
2003
2003
2003
2003
2003
2003
2003
2003
2003
2004
2004
2004
2004
2004
2004
2004
2003
2003
2003
2003
2004
2004
Woodlands Academy of the Sacred Heart, “Human Genetics: An Oracle to Your
Future Health?” Lake Forest, IL.
American Thoracic Society, “Genetic Mapping of Lung Phenotypes in Rats with
Substituted chromosomes,” Seattle, WA.
University of Wisconsin-Madison, Wisconsin Symposium III, “System Analysis in the Rat,” Madison, WI.
Universitat Regensburg, Klinik und Poliklink fur Innere Medizin II, "Sequence,
Systems Biology and Progress Towards Unraveling Cardiovascular Disease,"
Regensburg, Germany.
Society of Toxicology, “Rat Genetic Models for Disease; Efficacy Testing and
ADMET,” Savannah, GA.
International Diabetes Federation, “Animal Models and Diabetes
Complications,” Lille, France.
Duke Clinical Research Institute, Genetics of Cardiovascular Disease
Symposium, “Animal Models and Comparative Genomics,” Arlington, VA.
The Jackson Laboratory, “Applying Microarrays to Complex Disease Studies,”
Bar Harbor, ME.
National Institute of Health, National Heart, Lung and Blood Institute, “Program for Genomic Applications,” Bethesda, MD.
The American Physiological Society, “The Genetic Basis of End Stage Renal
Disease,” Augusta, GA.
The American Society of Human Genetics, “Animal Models of Human Complex
Disease,” Los Angeles, CA.
American Heart Association, “Physiologic Genomics of Hypertensive Renal
Failure,” Orlando, FL.
American Society of Nephrology, “Renal Failure,” San Diego, CA.
American Society of Human Genetics, “Animal Models of Human Complex
Disease,” Los Angeles, CA.
Specialized Center of Research, Hypertension Program Grantees’, “Update on
Program of Genomic Applications,” Bethesda, MD.
International Society of Hypertension 20 th Scientific Meeting, “Gene Hunting
Using the Physiological Toolset: Practical Demonstrations,” Sao Paulo, Brazil
University of Washington, School of Medicine, “Application of Comparative
Genomics to Common Complex Disease,” Seattle, Washington.
American Physiological Society, Experimental Biology 2004, “Rat Cardiovascular
Functional Genomics,” Washington, D.C.
Medical Research Council Workshop on Integrative Physiology, “Program in
Genomic Applications, A Model for Collaborative Research,” London, UK.
Cambridge Healthtech Institute, Beyond Genome 2004, “Using genetics and genomics in the rat to build better models for efficacy, toxicology and disease characterization,” San Francisco, CA.
Wisconsin Section, American College of Obstetricians & Gynecologists &
Wisconsin Society of Obstetrics and Gynecology, “Clinical Applications of the
Human Genome,” Wisconsin Dells, WI.
National Institute of Health, National Heart, Lung and Blood Institute, Program in Genomic Application and Rat Genome Database update/hands on computer training and tutorial, Washington, D.C.
The Institute for Genomic Research, 16 th International Genome Sequencing and Analysis Conference, “Reducing Failures in Clinical Trials by Increasing the
Predictive Power of Animal Models,” Washington, D.C.
24

2005
2005
2005
2005
2005
2005
2004
2004
2004
2004
2004
2005
2005
2005
2005
2005
2006
2006
2006
2006
2006
2006
The Jackson Laboratory, Genetic Approaches to Complex Heart, Lung and
Blood Diseases, “From QTL to Gene,” Bar Harbor, ME.
National Institute of Health, Long Term Maintenance of Genome Sequence
Assemblies: Human & Other Genomes meeting, Herndon, Virginia.
Columbia St. Mary’s Hospital, Medical Grand Rounds, “Individualized Medicine
Will We Be Ready?” Milwaukee, WI.
University of California – San Francisco Biomedical Sciences Seminar Series,
“Chromosome Substitution Strains: Linking Complex Diseases to Systems
Biology,” San Francisco, CA.
Cambridge Healthtech Institute’s 2 nd Annual Predictive Toxicology,
“Pharmacogenetic Models for Predictive Toxicology, San Francisco, CA.
University Medical Centre Nijmegen/Nijmegen Centre for Molecular Life
Sciences, “Chromosome Substitution Strains & Building Models for Human
Disease,” The Netherlands.
National Institute of Health, National Institute of Environmental Health
Sciences, “Building Better Rat Models for Safety and Efficacy Testing,
Triangle Research Park, NC.
Cambridge Healthtech Institute, Molecular Medicine Tri-Conference, “Rapid
Target Identification Using Rat Genomics Sequencing,” San Francisco, CA.
Federal Drug Administration, 11 th Annual Science Forum, “Building Better
Animal Models for Safety and Efficacy Test – is it Possible?” Washington, D.C.
The Jackson Laboratory, Predictive Models for Drug Safety Assessment,
“Building Better Animal Models for Safety and Efficacy Test – is it Possible?” Bar
Harbor, ME.
Universitat Regensburg, Genetics in Atherosclerosis and Cardiovascular Disease
Symposium, “Chromosome Substitution and Factors Influencing Cardiovascular
Disease, Regensburg, Germany.
National Institute of Health, National Institute of Environmental Health
Sciences, ICEM 2005 Satellite Meeting: Toxicogenomics, “The Rat Genome
Database and Rat Model Systems for Pharmacological and Toxicological
Research,” Kauai, HI.
Toho University School of Medicine, “Building Better Animal Models for Human
Disease,” Tokyo, Japan.
Iowa State University, “Individualized Medicine, Fact or Fiction?” Ames, Iowa
University College Utrecht, “Mining Rat Data in a Functional Genomics World,
Utrecht, The Netherlands.
American Society of Nephrology, Renal Week 2005, “Phenome Informatics: The
Rat Example,” Philadelphia, PA.
Goteborg University, “Rat Models in Biomedical Research,” Goteborg, Sweden
National Institutes of Health, National Center for Research Resources, “Rat
Models and Resources,” Bethesda, MD.
The Institute for Genomic Biology, “Individualized Medicine, Fact or Fiction?”
Urbana, IL.
Cambridge Healthtech Institute, World Pharmaceutical Congress, “The Rat
Remains a Major Model System within the Pharmaceutical Industry,”
Philadelphia, PA.
National Institutes of Health, National Institutes of Health, Department of
Health and Human Services, NIH Roadmap, “Building Better Animal Models
Using Population Genetics & Comparative Genomics”, Bethesda, MD.
The TMJ Association, Fourth Scientific Meeting, “Genetics as a Glue for
Translational Research,” Bethesda, MD.
25

2006
2006
2006
2007
2007
2007
2007
2008
2008
2008
2008
2008
2008
2008
2008
2008
2008
2008
2008
2008
2009
2009
2009
Twentieth International Mouse Genome Conference, “Rat Genome Database
Disease Portals: A Platform for Genetic and Genomic Research,” Charleston,
SC.
Cold Spring Harbor Laboratory, Pharmacogenomics, “Building Better Models for
Toxicity & Efficacy Testing, Cold Spring Harbor, NY.
The Australian Health & Medical Research Congress, Rat Genomes & Models,
“Searching for Renal Failure Genes Using the Rat Genomic Toolbox: What Else
Do We Need?” Melbourne, Australia.
Hinxton Hall, Ltd., Wellcome Trust Genome Campus, “Rat Genome Database
Potential Contributions to the Genome Assembly,” Cambridge, England.
University of Nebraska, Ross McIntyre Lecture, “Using Tissue Engineering and
Genomics to Understand Myocardial Infarction,” Omaha, NE.
The Jackson Laboratory, Discovery Strategies Conference, “Using Rat Models to
Understand T2D Pathophysiology,” Bar Harbor, ME.
Cold Spring Harbor Laboratory, Rat Genomics & Models, “Tacrine Toxicity
Detected in a Rat Test Population,” Cold Spring Harbor, NY.
The Association for Research in Otolaryngology, “Translational Research within an Academic Medical Center in an Era of the Clinical and Translational Science
Awards,” Phoenix, AZ.
MRC Clinical Sciences Centre European Rat Tools for Functional Genomics 2 nd
Annual Meeting, “Linking Clinical Cardiovascular Studies to Program for
Genomic Applications,” Glasgow, UK.
International Symposium on Animal Functional Genomics, “The Complex Nature of QTLS: How Many Genes are Under the Peak?” Edinburgh, UK.
Hypertension 2008, Chair Genetics/Genomics, Berlin, Germany.
Thirteenth International SHR Symposium, “Changing Roles of Genetics and
Genomics,” Prague, Czech Republic.
Slovenskej Akademie Vied, “Understanding Common Disease Through
Molecular Genetics: An Example Using Kidney Failure,” Bratislava, Slovak
Republic.
Comenius University, “Genetic Tools for Dissection of Common, Complex
Disease: Bench-side to Bedside,” Martin, Slovak Republic.
National Institute of Health, National Heart, Lung, and Blood Institute,
Genotype-Phenotype Working Group in Sickle Cell Disease, “An Introduction to
Computational Models and Systems Biology,” Bethesda, MMD.
National Institute of Health, The Fifth DCVD Visiting Professor Lecture Series
Seminar, “Systems Biology to Understand GWAS Results,” Bethesda, MD.
Sigma-Aldrich, “The Role of Transgenic Rats in a Genome Wide Association
Studies (GWAS) World”.
Broad Institute of Harvard & MIT, “After the GWAS is Done, New Roles of
Animal Models?”.
Iowa State University CIAG Pfizer Genomics Scholar Forum, “Integration of
Medicine and Genomics: The Impact of High Throughput Sequencing”.
Cold Spring Harbor, Hinxton UK. “Identification of R
-1”.
University of Kansas Medical Center Research Seminar Series in Cancer &
Developmental Biology, “Using Chromosome Substitution Strains and Site
Directed Mutagenesis Knockouts in Rats to Study Cancer”.
Case Western Reserve University School of Medicine, Department of Genetics
Research Seminar “Role of Animal Models in a GWAS World”.
EuraTools, Barcelona, Spain.
26

2010
2010
2010
2011
2011
2011
2011
2011
2011
2011
2009
2009
2009
2010
2010
2010
2010
2009
2009
2009
2009
2009
2009
2009
2010
University of Wisconsin, Madison, Genomic Seminar Series, “From Genome
Wide Association Studies (GWAS) to Understanding Common Disease”.
Monash University, Melbourne, Australia, “The Role of Animal Models in a
Genome Wide Association Study (GWAS) World”.
Vanderbilt University, Nashville, Integrative Genomics Seminar Series, “Genome
Wide Association Studies and Animal Models for Understanding Cardiovascular
Disease”.
Egyptian Society of Endocrinology, “Tissue Engineering: Inducible Pluripotent
Stem Cells and its Impact on Clinical Medicine in the Future”.
AstraZeneca, Philadelphia, “Building Better Animal Models for Pre Clinical Drug
Testing”.
Marshfield Clinic, Eau Claire, “WGI, Today and Tomorrow”.
Marshfield Clinic, Wausau,”‘WGI, Today and Tomorrow”.
University of Wisconsin, Madison, B6/BTBR F2 project retreat.
2 nd Next Generation Sequencing Hinxton Retreat, UK.
Experimental Biology 2009 New Orleans, “The Rat Genome Contribution to understanding the Pathogenesis of Hypertension”.
11 th Annual Meeting of Dr. Victor Dzau Research Conference, Tokyo
“Translating Genome Wide Association Studies in Mechanisms”.
Plant & Animal Genome XVIII, San Diego, “3 rd Generation Sequencing and
Gene KO Coming to Herds and Flocks Near You”.
Grant Writing Workshop, Medical College of Wisconsin, “A successful career built on many, many triaged grants”.
Jackson Laboratory, Bar Harbor, Animal Models for Human Stem Cell Therapy.
“The Rat – it’s not just for Physiology any more”.
Genomics of Common Diseases 2010, Baylor College of Medicine, Houston TX.
“From GWAS to function for hypertension and renal disease using sensitizied strains, transgenic rescue and gene KO”.
American Heart Association HBPR 2010, Washington DC. “Genetics of
Experimental Models of Hypertension”.
American Society of Nephrology. Denver CO. “Using Gene Knock-outs and
Transposon based transgenics in sensitized rat strains to study genes nominated by human GWAS for renal disease”.
The 18th International Workshop on Genetic Systems in the Rat, Kyoto Japan.
“Mechanisms related to hypertension associated renal disease”.
Hammersmith Lecture, Imperial College, London. “GWAS to mechanism of disease: role for gene knock out in sensitive strains”.
Charge Consortium meeting, Boston MA. “From GWAS to function for cardiovascular disease using sensitized strains, transgenic rescue and gene
KO”.
The Future of Genomic Medicine IV, Scripps Institute of Oceanography, San
Diego. “Bringing genomic sequence into the clinic: just another lab value?”
Research in Progress Series, Medical College of Wisconsin. “Translational medicine in an academic medical center: do I really want to do this?”
Otitis Media Symposium 2011, New Orleans LA. ‘Chinchilla to Human and
Personalized Medicine”.
Milwaukee Downtown Rotary. “The promise of personalized medicine: one in a billion”.
Partners HealthCare System, Brigham and Women’s Hospital, Boston MA.
“Bringing Genome Sequencing into the clinic: “just” another lab value?”
27

2011
2011
2011
2011
2011
2011
2011
2011
2011
2011
2011
2011
2011
2012
2012
2012
Symposia:
2011
2012
2012
2012
2012
2012
Science Café, Community Engagement Key Function of CTSI, Milwaukee WI.
“One in a billion – a story of personalized genomic medicine.”
The Translational Sciences Department at Abbott Laboratories, Translational
Sciences Seminar Series. “Building better models of human diseases from
Genome Wide Association Studies in human to rat models”.
Singularity University, San Francisco CA, 2011 Graduate Summer Program
Biotechnology and Bioinformatics track. “Saving lives with DNA”.
Jackson Laboratory. Invited Lecturer at Genomic & Proteomic Approaches to
Complex Heart, Lung, Blood and Sleep Discorders. Bar Harbor, Maine “Rat”.
CAS International Symposium on Animal Models of Diseases, Beijing, China.
“Building Better Models of Human Disease Using ZFNs”.
American Association for Laboratory Animal Science National Meeting, San
Diego Ca. “Using ZFN to Generate Knock-Out Rats”.
Monash Medical Center, Institute of Medical Research (MIMR), Melbourne
Australia “Using gene editing and GWAS data to build models of human disease”.
Monash University, Australian Regenerative Medicine Institute, Melbourne,
Australia. ”Whole Genome Sequencing Just another Lab Test: The Milwaukee
Experience”.
Second Stem Cell and Bone Marrow Transplant Symposium, Bucaramanga,
Columbia. “Assessing cases for bone marrow transplant using whole gene sequencing”.
University of Sao Paulo Medical School, Sao Paulo, Brazil. “Sequencing for
Clinical Diagnosis”, “GWAS to Function”.
University of Wisconsin, Whitewater, Department of Biological Sciences
Colloquium course. “Whole genome sequencing for clinical diagnosis.”
7 th Annual Personalized Medicine Conference, Harvard Medical School, Boston
Ma. Case study “Gene Sequencing: Staking a Position in an Expanding
Industry.
University of Wisconsin, Madison, Department of Nutritional Sciences. “Using
Gene Knock-outs in rats to understand the results from Genome Wide
Association Studies and Re-sequencing studies in humans’.
Cold Spring Harbor, New York. ‘Using gene editing and GWAS data to build models of human disease’.
Genetically Engineered Models Department, Merck Research Labs, Rahway, NJ seminar “Building cardiovascular models using GWAS Data”.
Aab CVRI Seminar Series, University of Rochester Medical Center. “GWAS to
Whole Genome Sequencing in Patient Care: The Milwaukee Approach”.
Seminar Series, Medical University of South Carolina, Nephrology. “Genome
Sequencing – is it ready for the clinic?”.
Fifth Annual Future of Genomic Medicine Program, Scripps Seaside Forum, La
Jolla CA. “Personalized Medicine: Whole Genome Sequencing in the Clinic”.
HMGC Seminar Series, Children’s Memorial Research Center, Chicago IL
“Sequencing in the Clinic?”.
AMIA 2012 Joint Summits on Translational Science, San Francisco CA “Genome sequencing – is it ready for the clinic?”.
ACC12 Chicago Il. “Sequencing and Personalized Medicine”.
Experimental Biology 2012, San Diego CA. “Lessons from rat knockout and related genetically engineered models of hypertension”.
28

1996
1996
1996
1997
1997
1997
1997
1997
1997
1997
1998
1998
1998
1998
1999
1999
1992
1992
1992
1993
1996
1994
1994
1994
1995
1995
1995
1995
1996
1996
1996
Fourth Robert C. Tarazi Symposium, “Molecular Genetics of Hypertension,”
Cleveland Clinic Foundation, Cleveland, OH
Canadian Animal Production Network Biozootech Workshop, Halifax, Nova
Scotia, Canada
The Tissue Renin-Angiotensin Systems, “From Molecular Biology to Clinical
Disease,” Stanford University, Stanford, CA
“Cellular and Molecular Biology of the Cardiovascular System,” Julian Claveria,
Spain
Sixth European Meeting on Hypertension, “Satellite Symposium on Molecular
Biology of Hypertension for Clinicians,” Milan, Italy
International Society of Hypertension Meeting, “Genes and Genetics Satellite,”
Sydney, Australia
Ethnic Differences in Hypertension, “Diet, Genetics and Social Factors,”
Columbia University, New York, NY
University of Florida, “International Symposium on Cellular and Molecular
Aspects of Angiotensin Receptors,” Gainesville, FL
European Hypertension Genetics Symposium, Max Delbruck Center, Berlin
Symposium on Quantitative Genetics, Bar Harbor, ME
Quantitative Genetics Symposium, Regensberg, Germany
HUGO, Comparative Mapping Symposium, Brisbane, Australia
American Academy of Allergy Asthma and Immunology, New Orleans, LA
Genetics Symposium, International Society of Hypertension, Glasgow, UK
Molecular Genetics of Complex Cardiovascular and Metabolic Disease, Stanford
University, Stanford, CA
Allerton II, “Genetic Analysis of Economically Important Traits of Livestock,”
University of Illinois, Chicago, IL
Fourth Symposium by the ESSM, “Genes and Cardiovascular Disease: Damage or Salvage?” Brescia, Italy
Ninth International Vascular Biology Meeting, Seattle, WA
American Physiological Society Experimental Biology 97, “Genomics to
Physiology: How Do We Get There,” New Orleans, LA
Nature Genetics Conference, “Functional Genomics: From Genes to Drugs,”
Washington, DC
Ninth International Symposium, “SHR and Cardio-Vascular Genetics,” Montreal,
Canada
Satellite Symposium, “Predictive Preventive Medicine for Hypertensive
Cardiovascular Diseases (CVD),” Kyoto, Japan
The 2 nd Shizuoka Forum on Health and Longevity Program, Shizuoka, Japan
Fifteenth Ernst Klenk Conference, Cologne, Germany
Free University, Berlin, Germany
QTL Mapping in Animal Models Workshop, Center for Environmental Genetics,
University of Cincinnati
Experimental Biology 98 In Focus Program, San Francisco, CA
Seventeenth ISH Meeting, “Interaction of Genetic and Environmental Factors in the Etiology of Hypertension,” Prague, Czech Republic
The Jackson Laboratory First Annual Meeting, “Rodent Models in Modern Risk
Assessment,” Bar Harbor, ME
Japan/US, National Academy of Science
Merck Research Laboratories, Metabolic Diabetes Complications, West Point, PA
29

1999
1999
1999
1999
2000
2000
2001
2001
2001
2002
2002
2002
Howard Hughes Medical Institute/University of Wisconsin Medical School,
University of Wisconsin Comprehensive Cancer Center, “Genetics, Genomics and Molecules,” Madison, WI
Cold Spring Harbor Laboratory, Genome Mapping and Sequencing, “Genetics of
Complex Traits,” Cold Spring Harbor, NY
The Jackson Laboratory/Hoffmann-La Roche, “Advanced Approaches to
Complex Diseases,” Roche Nutley, NY
Keystone Symposium, “Molecular Biology of the Cardiovascular System (A3),”
Snowbird, CO
The Future of Molecular Medicine, Berlin, Germany
International Society of Hypertension “End Stage Renal Disease With and
Without Hypertension,” Chicago, IL
Tenth International Symposium, Rat Genetics, Genomics and Model Systems for Human Disease, “NHLBI’s program in Genomic Application,” Berlin,
Germany
Wisconsin Symposium on the Analysis of Human Biology, Genes, Genomes and
Molecules, “Functional Genomics, from Rat to Man,” University of Wisconsin-
Madison, Madison, WI
American Heart Association, Scientific Sessions 2001, “Genetic Interactions in
Multigene Disorders,” Anaheim, CA
Division of Intramural Research of the National Human Genome Research
Institute, Bethesda, MD
Annual Meeting, American Society of Human Genetics, Moderate 52 nd
Baltimore, MD
The American Society of Nephrology 35 th Annual Meeting and Scientific
Exposition, Symposium Moderator, Philadelphia, PA
Wisconsin Symposium III, University of Wisconsin-Madison, Madison, WI 2003
2003
2004
2005
2007
2007
2008
2009
2009
Cold Spring Harbor Laboratory, Rat Genomics & Models, Cold Spring Harbor,
NY
Society of Toxicology 43 rd Annual Meeting, Baltimore, MD
National Institute of Environmental Health Sciences, National Toxicology
Program 2005, Research Triangle Park, NC
National Heart, Lung and Blood Institute Systems Medicine Workshop,
Bethesda, MD
Clinical Research Forum, Analysis, Advocacy, Action, Washington, DC
Laird Center for Medical Research dedication ‘Building the Future of Medicine’.
Genetics panel discussion.
University of Wisconsin, Madison Genomics Seminar Series. “From Genome
Wide Association Studies (GWAS) to understanding common disease.
Experimental Biology 2009 New Orleans, ‘The Rat Genome Contribution to understanding the Pathogenesis of Hypertension’.
Bibliography:
Original Reports
1.
Alper RH, Jacob HJ, Brody MJ. Regulation of arterial pressure labiality following sinoaortic deafferentation in rats. Am J Physiol. 1987 Aug;253(2 Part 2):H466-74. PMID: 3618819
2.
Alper RH, Jacob HJ, Brody MJ. Central and peripheral mechanisms of arterial pressure labiality following baroreceptor denervation. Canadian J Physiol Pharmacol. 1987
Aug;65(8):1615-18. PMID: 3121155.
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3.
Jacob HJ, Barres CP, Machado BH, Brody MJ. Studies on neural and humeral contributions to arterial pressure labiality. Am J Med Sci. 1988 Apr;295(4):341-5. PMID: 3284353.
4.
Lewis SJ, Barres C, Jacob HJ, Ohta H, Brody MJ. Cardiovascular effects on the N-methyl-D aspartate receptor antagonist MK in conscious rats. Hypertension. 1989 Jun:13(6 Pt 2):759-
65. PMID: 2544522.
5.
Jacob HJ, Alper RH, Brody MJ. Lability of arterial pressure after baroreceptor denervation is not pressure dependant. Hypertension. 1989 Nov;14(5):501-10. 2807511.
6.
Jacob HJ, Lewis SJ, Alper RJ, Grosskreutz CL, Brody MJ. Role of peripheral mechanisms in arterial pressure labiality after sinoaortic deafferentation. Am J Physiol. 1991 Feb;260(2 Pt
2):R359-67. PMID: 1996723.
7.
Sigmund CD, Jones CA, Jacob HJ, Ingelfinger J, Kim U, Gamble D, Dzau VJ, Gross KW.
Pathophysiology of vascular smooth muscle Renin expression in Renin promoter-T-antigen transgenic mice. Am J Physiol. 1991 Feb;260(2 Part 2):F249-57. PMID: 1996675.
8.
Jacob HJ, Alper RH, Grosskreutz CL, Lewis SJ, Brody MJ. Vascular tone influences arterial pressure liability after sionoaortic deafferent. Am J Physiol. 1991 Feb;260(2 Pt 2):359-67.
PMID: 1996723.
9.
Jacob HJ, Sigmund CD, Shockley TR, Gross KW, Dzau VJ. Renin promoter SV40 T-antigen transgenic mouse. A model of primary renal vascular hyperplasia. Hypertension. 1991
Jun;17(6 Pt 2):1167-72. PMID: 2045162.
10.
Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao Y, Ganten D, Dzau VJ,
Lander ES. Genetic mapping of a gene causing hypertension in the spontaneously hypertensive rat. Cell. 1991 Oct 4;67(1):213-24. PMID: 1655275.
11.
Dzau VJ, Jacob HJ, Lindpaintner K, Ganten D, Lander ES. Genetic mapping in hypertension.
J Vasc Surg. 1992 May;15(5):930. PMID: 1578573.
12.
Barres C, Lewis SJ, Jacob HJ, Brody MJ. Arterial pressure labiality and renal sympathetic nerve activity are dissociated in SAD rats. Am J Physiol. 1992 Sep;263(3 Pt 2):R639-46.
PMID: 1415652.
13.
Schunkert H, Ingelfinger JR, Jacob HJ, Jackson B, Dzau VJ. Reciprocal regulation of renal
Renin and angiotensinogen gene expression by angiotensin II. Am J Physiol. 1992 Nov;263(5
Pt 1):E863-9. PMID: 1443118.
14.
Kimura S, Mullins JJ, Bunnemann B, Metzger R, Hilgenfeldt U, Zimmermann F, Jacob HJ,
Fuxe K, Ganten D, Kaling M. High blood pressure in transgenic mice carrying the rat angiotensinogen gene. EMBO J. 1992 Mar;11(3):821-7. PMID: 1547785.
15.
Jacob HJ, Pettersson A, Wilson D, Mao Y, Lernmark Å, Lander ES. Genetic dissection of autoimmune type I diabetes in the BB rat. Nature Genetics. 1992 Sep;2(1):56-60. PMID:
1303251.
16.
Schunkert H, Ingelfinger JR, Hirsch AT, Pinto Y, Jacob H, Dzau VJ. Feedback regulation of angiotensin of converting enzyme activity and mRNA levels by angiotensin II. Circ Res. 1993
Feb;72(2):312-8. PMID: 8380358.
17.
Rakugi H, Jacob HJ, Krieger JE, Ingelfinger JR, Pratt RE. Vascular injury induces angiotensinogen gene expression in the media and neointima. Circulation. 1993
Jan;87(1):283-90. PMID: 8419017.
18.
Koike G, Krieger JE, Jacob HJ, Masashi M, Pratt RE, Dzau VJ. Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme. Biochem
Biophys Res Commun. 1994 Jan 14;198(1):380-6. PMID: 8292044.
19.
Hsu LC, Kennan WS, Shepel L, Jacob HJ, Szpirer C, Lander ES, Gould MN. Genetic identification of Mcs-1, a rat mammary carcinoma suppressor gene. Cancer Res. 1994 May
15;54(10):2765-70. PMID: 8168109.
20.
Koike G, Horiuchi M, Yamada T, Szpirer C, Jacob HJ, Dzau VJ. Human type 2 angiotensin II receptors gene cloned, mapped to the X chromosome and its mRNA is expressed in the human lung. Biochem Biophys Res Commun. 1994 Sep 30;203(3):1842-50. PMID: 7945336.
31

21.
Jacob HJ, Brown D, Bunker R, Daly MJ, Dzau VJ, Goodman A, Koike G, Kren V, Kurtz T,
Lernmark Å, Levan G, Mao Y, Pettersson A, Pravenec M, Simon JS, Szpirer C, Szpirer J,
Trolliet MR, Winer E, Lander ES. A genetic linkage map of the laboratory rat, Rattus norvegicus. Nature Genetics. 1995 Jan;9(1):63-69. PMID: 7704027.
22.
Truett GE, Jacob HJ, Miller J, Drouin G, Bahary N, Smoller JW, Lander ES, Leibel RL. Genetic map of rat chromosome 5 including the fatty (fa) locus. Mamm Genome. 1995 Jan;6(1):25-
30. PMID: 7719022.
23.
Tay A, Simon JS, Squire J, Jacob HJ, Skorecki K. Cytosolic phospholipase A2 gene in human and rat: chromosomal localization and polymorphic markers. Genomics. 1995 Mar
1;26(1):138-141. PMID: 7782073.
24.
Bloch KD, Wolfram JR, Roberts JD, Zapol DG, Lepore JJ, Filippov G, Thomas JE, Brown D,
Jacob HJ, and Bloch DB. Three members of the nitric oxide synthase II gene family colocalize to human chromosome 17. Genomics. 1995 Jun 10;27(3):526-30. PMID: 7558036.
25.
Pettersson A, Wilson D, Daniels T, Tobin S, Jacob HJ, Lander ES, Lernmark Å. Thyroiditis in the BB rat is associated with lymphopenia but occurs independently of diabetes. J.
Autoimmunity. 1995 Aug;8(4):493-505. PMID: 7492346.
26.
Pettersson A, Winer ES, Weksler-Zangen S, Lernmark Å, Jacob HJ. Predictability of heterozygosity scores and polymorphism information content values for rat genetic markers.
Mamm Genome. 1995 Aug;6(8):512-520. PMID: 8589519.
27.
Osten M, Den Bieman M, Jacob HJ, Szpirer J, Szpirer C, Bender K, Van Zutphen BFM. Use of simple sequence length polymorphisms for genetic characterization of rat inbred strains.
Mamm Genome. 1995 Sep;6(9):595-601. PMID: 8535065.
28.
Schork NJ, Krieger JK, Trolliet M, Franchini KG, Koike G, Krieger EM, Lander ES, Dzau VJ,
Jacob HJ. A biometrical genome search in rats reveals the multigenic basis of blood pressure variation. Genome Research. 1995 Sep;5(2):164-172. PMID: 9132270.
29.
Koike G, Jacob HJ, Krieger JE, Szpirer C, Hoehe MR, Horiuchi M, Dzau VJ. Investigation of the phenylethanolamine N-methyltransferase gene as a candidate gene for hypertension.
Hypertension. 1995 Oct;26(4):595-601. PMID: 7558218.
30.
Jacob HJ, Ramanathan A, Pan SG, Brody MJ, Myers GA. Spectral analysis of arterial pressure labiality in rats with sinoaortic deafferentation. American Journal of Physiology. 1995
Dec;269 (6 Pt 2):R1481-8. PMID: 8594953.
31.
Koike G, Winer ES, Horiuchi M, Brown DM, Szpirer C, Dzau VJ, Jacob HJ. Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene.
Hypertension. 1995 Dec;26(6 Pt 1):998-1002. PMID: 7490161.
32.
Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ. Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nature Genetics.
1996 Jan;12(1):44-51. PMID: 8528250.
33.
Galli J, Li LS, Glaser A, Ostenson C, Jiao H, Fakhrai-Rad H, Jacob HJ, Lander ES, Luthman H.
Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nature Genetics.
1996 Jan;12(1):31-7. PMID: 8528247.
34.
St. Lezin EM, Pravenec M, Wong AL, Liu W, Wang N, Lu S, Jacob HJ, Roman RJ, Stec DE,
Wang JM, Reid IA, Kurtz TW. Effects of Renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. J Clin Invest. 1996 Jan
15;97(2):522-27. PMID: 8567976.
35.
Lee JS, Adrie C, Jacob HJ, Roberts JD, Zapol WM, Bloch KD. Chronic inhalation of nitric oxide inhibits neointimal formation after balloon-induced arterial injury. Circ Res. 1996
Feb;78(2):337-42. PMID: 8575078.
36.
Jacob HJ. A landmark for orphan genomes? Nat Genet. 1996 May;13(1):14-5. PMID:
8673094.
37.
Simon JS, Deshmukh G, Couch FJ, Merajver SD, Weber BL, Van Vooren P, Tissil F, Szpirer J,
Szpirer C, Alper SL, Jacob HJ, Brosius FC III. Chromosomal mapping of the rat Slc4a family
32

of anion exchanger genes, Ae1, Ae2 and Ae3. Mamm Genome. 1996 May;7(5):380-2. PMID:
8661729.
38.
Stec DE, Trolliet MR, Krieger JE, Jacob HJ, Roman RJ. Renal cytochrome P4504A activity and salt sensitivity in spontaneously hypertensive rats. Hypertension. 1996 Jun;27(6):1329-
36. PMID: 8641744.
39.
Chung H, Roberts CT, Greenberg S, Rebeck GW, Christie R, Wallace R, Jacob HJ, Hyman BT.
Lack of association of trinucleotide repeat polymorphisms in the very low density lipoprotein receptor gene with Alzheimer’s disease. Ann Neurol. 1996 June;39(6):800-3. PMID:
8651653.
40.
Satler CA, Walsh E, Vesely M, Plummer MH, Ginsburg GS, Jacob HJ. Novel mis-sense mutation in the cyclic nucleotide-binding domain of HERG causes long QT syndrome. Am J
Medl Genet. 1996 Oct 2;65(1):27-35. PMID: 8914737.
41.
Koike G, Van Vooren P, Shiozawa M, Galli J, Li LS, Glaser A, Balasubramanyam A, Brown LJ,
Luthman H, Szpirer C, MacDonald JM, Jacob HJ. Genetic mapping and chromosome localization of the rat mitochondrial 3-phosphate dehydorogenase gene, a candidate for noninsulin-dependant diabetes mellitus. Genomics. 1996 Nov 15;38(1):96-9. PMID: 8954787.
42.
Otsen M, den Bieman M, Kuiper MTR, Pravenec M, Kren V, Kurtz TW, Jacob HJ, Lankhorst A.
Van Zutphen BFM. Use of AFLP markers for gene mapping and QTL detection in the rat.
Genomics. 1996 Nov 1;37(3):289-94. PMID: 8938440.
43.
Knapik EW, Goodman A, Atkinson OS, Roberts CT, Shiozawa M, Sim CU, Weksler-Zangen S,
Trolliet MR, Futrell C, Innes BA, Koike G, McLaughlin MG, Pierre L, Simon JS, Vilallonga E, Roy
M, Chiang P-W, Fishman MC, Driever W, Jacob HJ. A reference cross DNA panel for zebrafish (Danio rerio) anchored with simple sequence length polymorphisms. Development.
1996 Dec;123:451-60. PMID: 9007262.
44.
Schork NJ, Nath SP, Lindpainter K, Jacob HJ. Extensions to quantitative trait locus mapping in experimental organisms. Hypertension. 1996 Dec;28(6):1104-11. PMID: 8952606.
45.
Larsson M, Tissir F, Walter L, Gunther E, Jacob HJ, Klinga-Levan K, Levan G. Mapping of the rat ribosomal protein S18 gene (Rps 18) to chromosome 20p12. Mamm Genome. 1996
Jan;7(1):90. PMID: 8903742.
46.
Jiang J, Stec DE, Drummond H, Simon JS, Koike G, Jacob HJ, Roman RJ. Transfer of a saltresistant renin allele raises blood pressure in Dahl salt-sensitive rats. Hypertension. 1997
Feb;29(2):619-27. PMID: 9040448.
47.
Stelzner T, Hofmann TA, Brown DM, Deng AY, Jacob HJ. Genetic determinants of pulmonary hypertension in fawn-hooded rats. Chest. 1997 Jun;111(6 Suppl):96S. PMID: 9184548.
48.
Szpirer C, Szpirer J, Vanvooren P, Riviere M, Maget B, Svoboda M, Shiozawa M, Simon JS,
Jacob HJ, Koike G. Localization of the rat genes encoding glucagon, glucagon receptor, and insulin receptor, candidates for diabetes mellitus susceptibility loci. Mamm Genome. 1997
Aug;8(8):586-8. PMID: 9250867.
49.
Zhang, QY, Dene H, Deng AY, Jacob HJ, Rapp JP. Interval mapping and congenic strains for a blood pressure QTL on rat chromosome 13. Mamm Genome. 1997 Sep;8(9):636-41. PMID:
9250867.
50.
Van Dokkum, RPE, Jacob HJ, Provoost AP. Difference in susceptibility to develop renal damage in normotensive fawn-hooded (FHL) and August Copenhagen Irish (ACI) rats after
N(omega)-n arginine methyl ester induced hypertension. Am J Hypertens. 1997 Oct;10(10 Pt
1):1109-16. PMID: 9370381
51.
Schunkert H, Broeckel U, Kromer EP, Elsner D, Jacob HJ, Riegger GA. A large pedigree with vavuloseptal defects. Am J Cardiol. 1997 Oct 1;80(7):968-70. PMID: 9382022.
52.
Harris EL, Grigor MR, Innes BA, Harrap SB, Koike G, Jacob HJ. Strain-specific deletions in exon 10 of rat K-kininogen and T1-kininogen genes allow mapping of both genes to rat chromosome 11. Mamm Genome. 1997 Oct;8(10):791-2. PMID: 9321484.
33

53.
Koike G, Miano J.M, Vanvooren P, Shiozawa M, Szpirer C, Jacob HJ. Mapping of the rat
SM22 gene to Chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophy. Mamm Genome. 1998 Jan;9(1):76-7. PMID: 9434951
54.
Innes BA, McLaughlin M, Kapuscinski MK, Jacob HJ, Harrap SB. Independent genetic susceptibility to cardiac hypertrophy in inherited hypertension. Hypertension. 1998
Mar;31(3):741-6. PMID: 9495256.
55.
Jiang J, Jacob HJ. EbEST: An automated tool using expressed sequence tags to delineate gene structure. Genome Res. 1998 Mar;8(3):268-75.
56.
Brown DM, Van Dokkum RP, Korte MR, McLaughlin MG, Shiozawa M, Jacob HJ, Provoost AP.
Genetic control of susceptibility for renal damage in hypertensive fawn-hooded rats. Ren Fail.
1998 Mar;20(2):407-11. PMID: 9574469.
57.
Bieg S, Koike G, Klaff L, Pettersson A, MacMurray AJ, Jacob HJ, Lander ES, Lernmark Å.
Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat. Mamm Genome.
1998 Apr;9(4):324-6. PMID: 9530633.
58.
Broeckel U, Shiozawa M, Kissebah AH, Provoost AH, Jacob HJ. Susceptibility genes for endorgan damage. New strategies to understand diabetic and hypertensive nephropathy.
Nephrol Dial Transplant. 1998 Apr;13(4):840-2. PMID: 9568834.
59.
Knapik EW, Goodman A, Ekker M, Chevrette M, Delgado J, Neuhauss S, Shimoda N, Driever W
Fishman MC, Jacob HJ. A microsatellite genetic linkage map for zebrafish (Danio rerio). Nat
Genet. 1998 Apr;18(4):338-43. PMID: 9537415.
60.
Van Dokkum RP, Jacob HJ, Provoost AP. Genetic differences define severity of renal damage after L-NAME-induced hypertension in rats. J Am Soc Nephrol. 1998 Mar;9(3):363-71. PMID:
9513898.
61.
Brown DM, Matise TC, Koike G, Zangen S, Simon JS, McLaughlin MG, Winer ES, Chakravarti A,
Lander ES, Jacob HJ. An integrated genetic linkage map of the laboratory rat. Mamm
Genome. 1998 Jul;9(7):521-30. PMID: 9657848.
62.
Szpirer C, Szpirer J, Van Vooren P, Tissir F, Simon JS, Koike G, Jacob HJ, Lander ES, Helou K,
Klinga-Levan K, Levan G. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Mamm Genome. 1998 Sep;9(9):721-34. PMID:
9716657.
63.
Moralejo DH, Wei S, Wei K, Weksler-Zangen S, Koike G, Jacob HJ, Hirashima T, Kawano K,
Sugiura K, Sasaki Y, Ogino T, Yamada T, Matsumoto K. Identification of quantitative trait loci for non-insulin-dependent diabetes mellitus that interact with body weight in the Otsuka
Long-Evans Tokushima Fatty rat. Proc Assoc Am Physicians. 1998 Nov-Dec;110(6):545-58.
PMID: 9824537.
64.
Van Dokkum RPE, Alonso-Galicia M, Provoost AP, Jacob HJ, Roman RJ. Impaired autoregulation of renal blood flow in the fawn-hooded rat. Am J Physiol. 1999 Jan;276(1 Pt
2):R189-96. PMID: 9887194.
65.
Koike G, Chiche JD, Shiozawa M, Simon JS, Szpirer J, Jacob HJ, Szpirer C, Bloch KD.
Localization of rat genes in the nitric oxide signaling pathway: candidates for the pathogenesis of complex diseases. Mamm Genome. 1999 Jan;10(1):71-3. PMID: 9892738.
66.
Wei S, Wei K, Moralejo DH, Ogino T, Koike G, Jacob HJ, Sugiura K, Sasaki Y, Yamada T,
Matsumoto K. Mapping and characterization of quantitative trait loci for non-insulindependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans
Tokushima Fatty Rat. Mamm Genome. 1999 Mar;10(3):249-58. PMID: 10051320.
67.
Van Dokkum RP, Sun CW, Provoost AP, Jacob HJ, Roman RJ. Altered renal hemodynamics and impaired myogenic responses in the fawn-hooded rat. Am J Physiol. 1999 Mar;276(3 Pt
2):R855-63. PMID: 10070148.
68.
Szpirer C, Szpirer J, VanVooren P, Tissir F, Kela J, Lallemand F, Hoebee B, Simon JS, Koike G,
Jacob HJ, Lander ES, Helou K, Klinga-Levan K, Levan G. Gene-based anchoring of the rat
34

genetic linkage and cytogenetic maps. Transplant Proc. 1999 May;31(3):1541-3. PMID:
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69.
Steen RG, Kwitek-Black A, Glenn C, Gullings-Handley J, Van Etten Van W, Atkinson OS, Appel
D, Twigger S, Muir M, Mull T, Granados M, Kissebah M, Russo K, Crane R, Popp M, Peden M,
Matise T, Brown DM, Lu J, Kingsmore S, Tonellato PJ, Rozen S, Slonim D, Young P, Knoblauch
M, Provoost A, Ganten D, Coleman S, Rothberg J, Lander ES, Jacob HJ. A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat. Genome Res. 1999
Jun;9(6):AP1-8. PMID: 10400928.
70.
Jacob HJ. Physiological genetics: application to hypertension research. Clin Exp Pharmacol
Physiol. 1999 Jul;26(7):530-5. PMID: 10405781.
71.
Glickman M, Malek RL, Kwitek-Black A, Jacob HJ, Lee NH. Molecular cloning, tissuespecific expression, and chromosomal localization of a novel nerve growth factor-regulated
G-protein-coupled receptor, nrg-1. Mol Cell Neurosci. 1999 Aug;14(2):141-52. PMID:
10532805.
72.
Jacob HJ. Functional genomics and rat models. Genome Res. 1999 Nov;9(11):1013-6.
PMID: 10405781.
73.
Fakhrai-Rad H, Jiao H, Li L, Glaser A, Koike George, Jacob HJ, Luthman H, Galli J. A rat genetic linkage map including 67 new microsatellite markers. Mamm Genome. 1999
Nov;10(11):1102-5. PMID: 10556432.
74.
Shimoda N, Knapik EW, Ziniti J, Sim C, Yamada E, Kaplan S, Jackson D, Sauvage F, Jacob
HJ, Fishman MC. Zebrafish genetic map with 2000 microsatellite markers. Genomics. 1999
Jun 15;58(3):219-32. PMID: 10373319.
75.
Klaff LS, Koike G, Jiang J, Wong Y, Bieg S, Pettersson A, Lander E, Jacob HJ, Lernmark Å.
BB Rat Diabetes susceptibility and body weight regulation genes colocalize on chromosome 2.
Mamm Genome. 1999 Sep;10(9):883-7. PMID: 10441739.
76.
Nobrega MA, Shiozawa M, Koike G, Jacob HJ, Miano JM. Gene structure and chromosomal mapping of the rat smooth muscle calponin gene.
Mamm Genome. 2000 Feb;11(2):115-9.
PMID: 10656925.
77.
Jones GT, Harris EL, Jacob HJ, van Rij AM. Spontaneous elastic tissue lesions in the rat abdominal aorta, a genetically determined phenotype. J Vasc Res. 2000 Mar-Apr;37(2):73-
81. PMID: 10754392.
78.
Baker JE, Konorev EA, Gross GJ, Chilian WM, Jacob HJ. Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection? Am J Physiol Heart Circ
Physiol. 2000 Apr;278(4):H1395-400. PMID: 10749737.
79.
Cowley AW, Stoll M, Greene AS, Kaldunski ML, Roman RJ, Tonellato, PJ, Schork NJ, Jacob
HJ. Genetically defined risk of salt sensitivity in an intercross Brown Norway and Dahl S rats. Physiol Genomics. 2000 Apr 27;2(3):107-15. PMID: 11015589
80.
Stoll M, Kwitek-Black AE, Cowley AW, Harris EL, Harrap SB, Krieger JE, Printz MP, Provoost
AP, Sassard J, Jacob HJ. New target regions for human hypertension via comparative genomics. Genome Res. 2000 Apr;10(4):473-82. PMID: 10779487 PMCID: PMC310887.
81.
Schork NJ, Chakravarti A, Thiel B, Fornage M, Jacob HJ, Cai R, Rotimi CN, Cooper RS,
Weder AB. Lack of association between a biallelic polymorphism in the adducin gene and blood pressure in whites and African Americans. Am J Hypertens. 2000 June;13(6 Pt
1):693-8. PMID: 10912755.
82.
Van Dokkum RPE, Jacob HJ, Provoost AP. Blood pressure and the susceptibility to renal damage after unilateral nephrectomy and L-NAME-induced hypertension in rats. Nephrol
Dial Transplant. 2000 Sep;15(9):1337-43. PMID: 15976509.
83.
Shiozawa M, Provoost AP, Van Dokkum RPE, Majewski R, Jacob HJ. Evidence of genegene interactions in the genetic susceptibility to renal impairment following unilateral nephrectomy. J. Am. Soc. Nephrol. 2000 Nov;11(11):2068-78. PMID:11053483.
35

84.
Gosele C, Hong L, Kreitler T, Rossmann M, Hieke B, Grob U, Kramer M, Himmelbauer H,
Bihoreau M, Kwitek-Black AE, Twigger S, Tonellato PJ, Jacob HJ, Schalkwyk LC,
Lindpaintner K, Ganten D, Lehrach H, Knoblauch M. High-throughput scanning of the rat genome using interspersed repetitive sequence-PCR markers. Genomics. 2000 Nov
1;69(3):287-94. PMID: 11056046.
85.
Ou H, Haendeler J, Aebly MR, Kelley LA, Koike G, Kwitek-Black AE, Jacob HJ, Berk BC,
Miano JM. Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells. Circ Res. 2000 Nov 10;87(10):881-7. PMID: 11073883.
86.
Zhu X, McKenzie CA, Forrester T, Nickerson DA, Broeckel U, Schunkert H, Doering A, Jacob
HJ, Cooper RS, Rieder MJ. Localization of a small genomic region associated with elevated
ACE. Am J Hum Genet. 2000 Nov;67(5):1144-53. PMID: 11001581 PMCID: PMC1288557.
87.
Kissebah AH, Sonnenberg GE, Myklebust J, Goldstein M, Broman K, James RG, Marks JA,
Krakower GR, Jacob HJ, Weber J, Martin L, Blangero J. Comuzzie AG. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of metabolic syndrome. Proc Natl
Acad Sci USA. 2000 Dec 19;97(26):14478-83. PMID: 11121050 PMCID: PMC18944.
88.
Schork NJ, Fallin D, Thiel B, Xu X, Broeckel U, Jacob HJ, Cohen D. The future of genetic case-control studies. Adv Genet. 2001;42:191-212. PMID: 11037322.
89.
Nadeau JH, Balling R, Barsh G, Beier D, Brown SD, Bucan M, Camper S, Carlson G,
Copeland N, Eppig J, Fletcher C, Frankel WN, Ganter D, Goldowitz D, Goodnow C, Guenet
JL, Hicks G, de Angelis MH, Jackson I, Jacob HJ, Jenkins N, Johnson D, Justice M, Kay S,
Kinglsey D, Lehrach H, Magnuson T, Meisler M, Poustka A, Rinchik EM, Rossant J, russell LB,
Schimenti J, Shioroishi T, Skarnes WC, Soriano P, Stanford W, Takahashi JS, Wurst W,
Zimmer A. Sequence interpretation. Functional annotation of mouse genome sequencing.
Science. 2001 Feb 16;291(5507):1251-5. PMID: 11233449.
90.
Kwitek-Black AE, Jacob HJ. The use of designer rats in the genetic dissection of hypertension. Curr Hypertens Rep. 2001 Feb;3(1):12-8. PMID: 11177702.
91.
Cowley AW, Roman RJ, Kaldunski ML, Dumas P, Dickhout JG, Greene AS, Jacob HJ. Brown
Norway chromosome 13 confers protection from high salt to consomic Dahl S rat.
Hypertension. 2001 Feb;37(2 Pt 2):456-61. PMID: 11230318.
92.
Sheetz TE, Raymond MR, Nishimura DY, McClain A, Roberts C, Birkette C, Gardiner J, Zhang
J, Butters N, Sun C, Kwitek-Black A, Jacob HJ, Casavant TL, Soares MB, Sheffield VC.
Generation of a high-density rat EST map. Genome Res. 2001 Mar;11(3):497-502. PMID:
11230173 PMCID: PMC311028.
93.
Stoll M, Jacob HJ. Genetic rat models of hypertension: relationship to human hypertension. Curr Hypertens Rep. 2001 Apr;3(2):157-64. PMID: 11276399.
94.
Tseng J, Kwitek-Black AE, Erbe CB, Popper P, Jacob HJ, Wackym PA. Radiation hybrid mapping of 11 alpha and beta nicotinic acetylcholine receptor genes in Rattus nrovegicus.
Brain Res Mol Brain Res. 2001 Jul 13;91(1-2):169-73. PMID: 11457506.
95.
Harris EL, Stoll M, Jones GT, Granados MA, Porteous WK, van Rij AM, Jacob HJ.
Identification of two susceptibility loci for vascular fragility in the Brown Norway rat. Physiol
Genomics. 2001 Aug 28;6(3):183-9. PMID: 11526202.
96.
Comuzzie AG, Funahaski T, Sonnenberg G, Martin LJ, Jacob HJ, Black AE, Maas D,
Takahashi M, Kihara S, Tanaka S, Matsuzawa Y, Blangero J, Cohen D, Kissebah A. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J Clin Endocrinol Metab. 2001 Sep;86(9):4321-5. PMID: 11549668.
97.
Weksler-Zangen S, Yagil C, Zangen DH, Ornoy A, Jacob HJ, Yagil Y. The newly inbred
Cohen diabetic rat: a non-obese normolipidemic genetic model of diet-induced type 2 diabetes expressing gender differences. Diabetes. 2001 Nov;50(11)2521-9. PMID:
11679430. PMID: 11679430.
98.
Kwitek-Black AE, Tonellato PJ, Soares MB, Chen D, Scheetz TE, Gullings-Handley J,
Casavant TL, Twigger S, Cheng YS, Stoll M, Sheffield VC, Jacob HJ. Automated
36

construction of high-density comparative maps between rat, human and mouse. Genome
Res. 2001 Nov;11(11):1395-43. PMID: 11691858 PMCID: PMC311144.
99.
Stoll M, Cowley AW Jr, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, Dumas P, Schork
NJ, Wang Z, Jacob HJ. A genomic-systems biology map for cardiovascular function.
Science. 2001 Nov 23;294(5547):1723-6. PMID 11721057.
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Roman, RJ, Cowley AW Jr, Greene A, Kwitek AE, Tonellato PJ, Jacob HJ. Consomic rats for the identification of genes and pathways underlying cardiovascular disease. Cold
Spring Harbor Symposia on Quantitative Biology. 2002 67:309-15. PMID: 12858554.
101.
Twigger S, Lu J, Shimoyama M, Chen D, Pasko D, Long H, Ginster J, Chen C, Nigam R,
Kwitek A, Eppig J, Maltais L, Maglott D, Schuler G, Jacob HJ and Tonellato P. Rat
Genome Database (RGD): Mapping disease onto the genome. Nucleic Acids Res. 2002
Jan 1;30(1):125-8. PMID: 11752273. PMCID: PMC99132.
102.
Kita Y, Shiozawa J, Jin W, Majewski RR, Besharse JC, Greene AS, Jacob HJ Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies. Pharmacogenetics. 2002 Jan;12(1):55-65. PMID: 11773865.
103.
Jacob HJ and Kwitek A. Rat genetics: Attaching physiology and pharmacology to the genome. Nature Reviews Genetics. 2002 Jan;3(1):33-42. PMID: 11823789.
104.
The FBPP Investigators. Multi-Center Genetic Study of Hypertension. Hypertension.
2002 Jan;39(1):3-9. PMID: 11799070.
105.
Broeckel U, Hengstenberg C, Mayer B, Holmer S., Martin L, Comuzzie A, Blangero J,
Nurnberg P, Reis A, Riegger G, Jacob HJ and Schunkert H. A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat Genet. 2002
Feb;30(2):210-14. PMID: 11818963.
106.
Yoon JW, Kita Y, Frank D, Majewski RR, Konicek BA, Nobrega MA, Jacob HJ, Walterhouse
D, Iannacconne P. Gene expression profiling leads to identification of GLI1 binding elements in target genes and a role for multiple downstream pathways in GLI1 induced cell transformation. J Biol Chem. 2002 Feb 15;277(7):5548-55. PMID: 11719506.
107.
Provoost AP, Shiozawa J, Van Dokkum RP, Jacob HJ. Transfer of the Rf-1 region from
FHH onto the ACI background increases susceptibility to renal impairment. Physiologic
Genomics. 2002 Feb;8(2):123-29. PMID: 11875190.
108.
Liang M, Yuan B, Rute E, Greene AS, Zou AP, Soares P, McQuestion GD, Slocum GR,
Jacob HJ, Cowley AW JR. Renal medullary genes in salt-sensitive hypertension: a chromosomal substitution and cDNA microarray study. Physiological Genomics. 2002
Feb;8(2):139-49. PMID: 11875192.
109.
Kendziorski CM, Cowley AW Jr, Greene AS, Salgado HC, Jacob HJ and Tonellato PJ.
Mapping Baroreceptor Function to Genome: A Mathematical Modeling Approach.
Genetics. 2002 Apr;160(4):1687-95. PMID: 11973321 PMCID: PMC1462065.
110.
MacMurray AJ, Moralejo DH, Kwitek AE, Rutledge EA, Van Yserloo B, Gohlke P, Speros SJ,
Snyder B, Schaefer J, Bieg S, Jiang J, Ettinger RA, Fuller J, Daniels TL, Pettersson A,
Orlebeke K, Birren B, Jacob HJ, Lander ES, Lerhmark A. Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide
(Ian)-related gene. Genome Research. 2002 Jul;12(7):1029-39. PMID: 12097339 PMCID:
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111.
Kotchen, TA, Broeckel U., Grim CE, Hamet P, Jacob HJ, Kaldunski ML, Kotchen JM,
Schork NJ, Tonellato PJ and Cowley AW Jr. Identification of Hypertension-Related QTLs in
African American Sib pairs. Hypertension. 2002 Nov;40(5):634-39. PMID: 12411455.
112.
Tseng J, Erbe CB, Kwitek AE, Jacob HJ, Propper P, Wackym PA. Radiation hybrid mapping of five muscarinic acetylcholine receptor subtype genes in Rattus norvegicus.
Hearing Research. 2002 Dec;174(1-2):86-92. PMID: 12433399.
37

113.
Ueno T, Tremblay J, Kunes J, Zicha J, Dobesova Z, Pausova Z, Deng AY, Sun Y, Jacob HJ,
Hamet P. Gender-specific genetic determinants of blood pressure and organ weight: pharmacogenetic approach. Physiol Res. 2003; 52(6):689-700. PMID: 14640890.
114.
Hessner, MJ, Wang X, Khan S, Meyer L, Schlicht M, Tackes J, Datta MW, Jacob HJ,
Ghosh S. Use of a three-color cDNA microarray platform to measure and control supportbound probe for improved data quality and reproducibility. Nucleic Acids Res. 2003 Jun
1;31(11):e60. PMID: 12771224 PMCID: PMC156737.
115.
Ueno T, Tremblay J, Kunes J, Zicha J, Dobesova Z, Pausova Z, Deng AV, Sun YL, Jacob HJ,
Hamet P. Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systems. J
Mol Med. 2003 Jan;81(1):51-60. PMID: 12545249.
116.
Datta YV, Wu FC, Dumas PC, Rangel-Filho A, Datta MW, Ning G, Cooley BC, Majewski RR,
Provoost AP, Jacob HJ. Genetic mapping and characterization of the bleeding disorder in the fawn-hooded hypertensive rat. Thromb Haemost. 2003 Jun;89(6):1031-42. PMID:
12783116.
117.
Moreno C, Dummas P, Kaldusnki ML, Tonellato PJ, Greene AS, Roman RJ, Cheng Q, Wang
Z, Jacob HJ, Cowley AW Jr. Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Physiol Genomics. 2003 Nov 11;15(3):243-57. PMID: 14532335.
118.
Moralejo DH, Park HA, Speros SJ, MacMurray AJ, Kwitek AE, Jacob HJ, Lander ES,
Lernmark A. Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat. J Autoimmun. 2003 Dec;21(4):315-324. PMID
14624755.
119.
Cioffi JA, Erbe CB, Raphael R, Kwitek AE, Tiwari UK, Jacob HJ, Popper P, Wackym PA.
Expression of G-protein alpha subunit genes in the vestibular periphery of Rattus novegicus and their chromosomal mapping. Acta Otolaryngol. 2003 Dec;123(9):1027-1034. PMID:
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120.
Vitt, U., Gietzen, D., Stevens, K., Wingrove, J., Becha, S., Bulloch, S., Burrill, J., Chawla, N.,
Chien, J., Crawford, M., Ison, C., Kearney, L., Kwong, M., Park, J., Policky, J., weiler, M.,
White, R., Xu, Y., Daniels, S., Jacob, H.J., Jensen-Seaman, M. I., Lazar, J., Stuve, L.,
Schmidt, J. Identification of candidate genes by EST alignments, synteny and expression and verification of Ensembl genes on rat chromosome 1q43-54. Genome Research 4: 640-
650, 2004. PMID: 15060005 PMCID: PMC383308.
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Cowley AW Jr., Roman RJ, Jacob, HJ. Application of chromosomal substitution techniques in gene-function discovery. J Physiol. 2004 Jan 1;554(Pt 1):46-55. PMID: 14678490 PMCID:
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122.
Mattson DL, Kunert MP, Kaldunski ML, Greene AS, Roman RJ, Jacob HJ, Cowley AW Jr.
Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats.
Physiol Genomics. 2004 Jan 15;16(2):194-203. PMID: 14600213.
123.
Ueno T, Tremblay J,Kunes J, Zicha J, Dobesova Z, Pausova Z, Deng, AY, Syn YL, Jacob HJ,
Hamet P. Rat model of familial combined hyperlipidemia as a result of comparative mapping. Physiol Genomics. 2004 Mar 12;17(1):38-47. PMID 14709677.
124.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen
D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-
Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG,
Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z,
Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T,
Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K,
Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu
B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A,
Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon
S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X,
38

Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML,
Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z,
Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E,
Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H,
Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Alba
M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hubner N,
Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H,
Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI,
Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S,
Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi
M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W,
Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews
TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM,
Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, Lopez-Otin
C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A,
Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS,
Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD,
Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri
U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F; Rat Genome Sequencing
Project Consortium. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature. 2004 Apr 1;428(6982):493-521. PMID: 15057822.
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Nobrega MA, Fleming S, Roman RJ, Shiozawa M, Schlick N, Lazar J, Jacob HJ. Initial characterization of a rat model of diabetic nephropathy. Diabetes. 2004 Mar;53(3):735-
742. PMID: 14988259.
126.
Jensen-Seaman MI, Furey TS, Payseur BA, Lu Y, Roskin KM, Chen CF, Thomas MA, Haussler
D, Jacob, HJ. Comparative recombination rates in the rat, mouse and human genomes.
Genome Res. 2004 Apr;14(4):528-538. PMID: 15059993 PMCID: PMC383296.
127.
Twigger SN, Nie J, Ruotti V, Yj J, Chen D, Li D, Mathis J, Narayanasamy V, Gopinath GR,
Pasko D, Shimoyama M, De La Cruz N, Bromberg S, Kwitek AE, Jacob HJ, Tonellato PJ.
Integrative genomics: in silico coupling of rat physiology and complex traits with mouse and human data. Genome Res. 2004 Apr;14(4)651-660. PMID: 15060006 PMCID: PMC383309.
128.
Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A,
Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield
VC, Tonellato PJ, Jacob HJ. High-density rat radiation hybrid maps containing over 24,000
SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Genome Res.
2004 Apr;14(4)750-757. PMID: 15060019 PMCID: PMC383322.
129.
Cowley AW Jr, Liang M, Roman RJ, Greene AS, Jacob HJ. Consomic rat model systems for physiological genomics. Acta Physiol Scand. 2004 Aug;181(4):585-92. PMID: 15283774.
130.
Michalkiewicz M, Michalkiewicz T, Ettinger RA, Rutledge EA, Fuller JM, Moralejo DH, Van
Yserloo B, Macmurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark A. Transgenic rescue demonstrates involvement of the Ian5 gene in cell development in the rat. Physiol
Genomics. 2004 Oct 4;19(2):228-32. PMID: 15328390.
131.
Bilusic M. Bataillard A, Tschannen MR, Gao L, Barretto NE, Vincent M, Wang T, Jacob HJ,
Sassard J, Kwitek AE. Mapping the genetic determinants of hypertension, metabolic disease and related phenotypes in the lyon hypertensive rat. Hypertension. 2004 Nov;44(5):695-
701. PMID:15452030.
132.
Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beav WD, Belknap JK,
Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M,
Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A,
Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld
H, Gordon T, Gu J, Gu W, de Haan G, Hayes NI, Heller C, Himmelbauer H, Hitzemann R,
39

Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK,
Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammer-Lassalle
JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR,
Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH,
Nagase H, Nowakowski RS, O’Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen-Palmer AA,
Pan HJ, Peltonen-Palotie L, Pierce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH,
Roder J, Rosen GD, Schadt EE, Schalkwyl LC, Seltzer Z, Shimomura K, Shou S, Sillanpaa MJ,
Siracusa LD, Snoec HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA,
Valdar W, de Villena FP, Warden C, Whatley S, Williams RW, Wiltshir T, Yi N, Zhang D,
Zhang M, Zou F; Complex Trait Consortium. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 2004 Nov;36(11):1133-7. PMID:
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133.
Baessler A, Hasinoff MJ, Fischer M, Reinhard W, Sonnenberg GE, Olivier M, Erdmann J,
Schunkert H, Doering A, Jacob HJ, Comuzzie AG, Kissebah AH, Kwitek AE. Genetic linkage and association of the growth hormone secretagogue receptor (Ghrelin receptor) gene in human obesity. Diabetes. 2005 Jan;54(1):259-67. PMID: 15616037 PMCID: PMC2793077.
134.
De La Cruz N, Bromberg S, Pasko D, Shimoyama M, Twigger S, Chen J, Chen CF, Fan C,
Foote C, Gopinath GR, Harris G, Hughes A, Ji Y, Jin W, Li D, Mathis J, Nenasheva N, Nie J,
Nigam R, Petri V, Reilly D, Wang W, Wu W, Zuniga-Meyer A, Zhao L, Kwitek A, Tonellato P,
Jacob HJ. The Rat Genome Database (RGD): developments towards a phenomenal database. Nucleic Acids Res. 2005 Jan 1:33 Database Issue:D485-91. PMID: 15608243
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Fischer M, Broeckel U, Holmer S, Baessler A, Hengstenberg C, Mayer B, Erdmann J, Klein G,
Riegger G, Jacob HJ, Schunkert H. Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction. Circulation. 2005 Feb 22;111(7):855-
62. PMID: 15710764.
136.
Rangel-Filho A, Sharma M, Datta YH, Moreno C, Roman RJ, Iwamoto Y, Provoost AP, Lazar
J, Jacob HJ. RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. JASN 2005 Apr;16(4):852-
60. Epub 2005 Mar 9. PMID: 15758045.
137.
Shi Y, Hutchins W, Ogawa H, Chang CC, Pritchard KA Jr, Zhang C, Khampang P, Lazar J.
Jacob HJ, Rafiee P, Baker JE. Increased resistance to myocardial ischemia in the Brown
Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90. J Mol Cell Cardiol. 2005
Apr;38(4):625-635. PMID: 15808839.
138.
Mattson DL, Kunert MP, Roman RJ, Jacob HJ, Cowley AW Jr. Substitution of chromosome
1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat.
Am J Physiol Renal Physiol. 2005 May;288(5):F1015-22. PMID: 15644486.
139.
Shimoyama M, Petri V, Pasko D, Bromberg S, Wu W, Chen J, Nenasheva N, Kwitek A,
Twigger S, Jacob HJ. Using multiple ontologies to integrate complex biological data. Comp
Funct Genomics. 2005;6(7-8):373-8.PMID: 18629202 PMCID: PMC2447497.
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Di Nicolantonio R, Kostka V, Kwitek A, Jacob HJ, Thomas WG, Harrap SB. Fine mapping of
Lvm1 : a quantitative trait locus controlling heart size independently of blood pressure. Pulm
Pharmacol Ther. 2006;19(1):70-3. Epub 2005 Apr 25. PMID: 162862.
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Dwinell MR, Forster HV, Petersen J, Rider A, Kunert MP, Cowley AW Jr, Jacob HJ. Genetic determinants on rat chromosome 6 modulate variation the hypercapnic ventilatory response using consomic strains. J Appl Physiol. 2005 May;98(5):1630-8. PMID: 15661838.
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Van Dijk SJ, Specht PA, Lazar J, Jacob HJ, Provoost AP. Renal Damage Susceptibility and
Autoregulation in Rf-1 and Rf-5 Congenic Rats. Nephron Exp Nephrol. 2005 Jun
20;101(2):e59-366. PMID: 15976509.
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Twigger SN, Pasko D, Nie J, Shimoyama M, Bromberg S, Campbell D, Chen J. Dela Cruz N,
Fan C, Foote C, Harris G, Hickmann B, Ji Y, Jin W, Li D, Mathis J, Nenasheva N, Nigam, R,
40

Petri V, Reilly D, Ruotti V, Schauberger E, Seiler K, Slyper R, Smith J, Wang W, Wu W, Zhao
L, Zuniga-Meyer A, Tonellato PJ, Kwitek AE, Jacob HJ. Tools and strategies for
Physiological Genomics – The Rat Genome Database. Physiol Genomics. 2005 Oct
17;23(2):246-56. Epub 2005 Aug 16. PMID: 16106031.
144.
Lopez B, Ryan RP, Moreno C, Sarkis A, Lazar J, Provoost AP, Jacob HJ, Roman RJ.
Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in Fawn
Hooded-Hypertensive rats. Am J Physiol Renal Physiol. 2005 Nov 22. PMID: 16303858.
145.
Van Dijk SJ, Spechat PA, Lutz MM, Lazar J, Jacob HJ, Provoost AP. Interaction between Rf-
1 and Rf-4 quantitative trait loci increases susceptibility to renal damage in double congenic rats. Kidney Int. 2005 Dec;68(6):2462-72. PMID: 16316323.
146.
Lazar J, Moreno C, Jacob HJ, Kwitek AE. Impact of genomics on research in the rat.
Genome Res. 2005 Dec;15(12):1717-28. PMID: 16339370.
147.
Malek RL, Wang HY, Kwitek AE, Greene AS, Bhagabati N, Borchardt G, Cahill L, Currier T,
Frank B, Fu X, Hassinoff M, Howe E, Letwin N, Luu TV, Saeed A, Sajadi H, Salzberg SL,
Sultana R, Thiagarajan M, Tsai J, Veratti K, White J, Quackenbush J, Jacob HJ, Lee NH.
Physiogenomic resources for rat models of heart, lung and blood disorders. Nat Genet.
2006 Feb;38(2):234. PMID: 16415889.
148.
Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard
JH, Mattson DL, Pritchard Jr KA, Roman RJ, Tonellato PJ, Cowley Jr AW. BN Phenome:
Detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. Physiol Genomics. 2006 Apr 13;25(2):303-13. PMID: 16478827.
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Van Dijk SJ, Specht PA, Lazar J, Jacob HJ, Provoost AP. Synergistic QTL interactions between Rf-1 and Rf-3 increase renal damage susceptibility in double congenic rats. Kidney
Int. 2006 Apr;69(8):1369-76. PMID: 16541022.
150.
Roman RJ, Hoagland KM, Lopez B, Kwitek AE, Garrett MR, Rapp JP, Lazar J, Jacob HJ,
Sarkis A. Characterization of blood pressure and renal function in chromosome 5 cogenic strains of Dahl S rats. Am J Physiol Renal Physiol. 2006 Jun 290(6):F1463-71. PMID:
16396943.
151.
Levan G, Jacob HJ. Nomenclature of the rat Cyp genes and the problems of gene nomenclature in general [Nelson, D.R. (2005), Gene nomenclature by default, or BLASTing to Babel, Hum. Genomics Vol. 2, pp. 196-201]. Hum Genomics. 2006 Jun;2(6):343; author reply 343-4. PMID: 16848971.
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Kunert MP, Drenjancevic-Peric I, Dwinell MR, Lombar JH, Cowley Jr AW, Greene AS, Kwitek
AE, Jacob HJ. Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt sensitive rat. Physiol Genomics. Aug 16;26(3):218-25. Epub 2006
Jun 13. PMID: 16772359.
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van Dijk SJ, Specht PA, Lazar J, Jacob HJ, Provoost AP. Absence of an interaction between the Rf-1 and Rf-5 QTLs influencing susceptibility to renal damage in rats. Nephron Exp
Nephrol. 2006 Jul 12;104(3):e96-e102. PMID: 16837819.
154.
Ali I, Rafiee P, Hogan WJ, Jacob HJ, Komorowski RA, Haasler GB, Shaker R. Dickkopf homologs in squamous mucosa of esophagitis patients are overexpressed compared with
Barrett’s patients and healthy controls. Am J Gastroenterol. 2006 Jul;101(7):1437-48.
PMID: 16863544.
155.
Schlick NE, Jensen-Seaman MI, Orlebeke K, Kwitek AE, Jacob HJ, Lazar J. Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strain. Am J
Physiol Cell Physiol. Dec;291(6):C1183-92. Epub 2006 Jul 19. PMID: 16855218.
156.
Meurer JR, Lustig JV, Jacob HJ. Genetic aspects of etiology and treatment of asthma.
Pediatr Clin North Am. 2006 Aug;53(4):715-725. PMID: 16873001.
157.
Wang X, Jia S, Meyer L, Xiang B, Chen LY, Jiang N, Moreno C, Jacob HJ, Ghosh S, Hessner
MJ. Comprehensive quality control utilizing the prehybridization third-dye image leads to
41

accurate gene expression measurements by cDNA microarrays. BMC Bioinformatics. 2006
Aug 14;7(1):378. PMID: 16907976.
158.
Twigger SN, Shimoyama M, Bromber S, Kwitek AE, Jacob HJ. The Rat Genome Database, update 2007 – Easing the path from disease to data and back again. Nucleic Acids Res.
2007 Jan;35(Database issue):D658-62. PMID: 17151068 PMCID: PMC1761441.
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Nye SH, Wittenburg AL, Evans DL, O’connor JA, Roman RJ, Jacob HJ. Rat survival to anthrax lethal toxin is likely controlled by a single gene. Pharmacogenomics J. 2007 Apr 17
[Epub ahead of print]. PMID: 19242337.
160.
Michalkiewicz M, Michalkiewicz T, Geurts AM, Roman RJ, Slocum GR, Singer O, Weinrauch
D, Greene AS, Kaldunski ML, Verma IM, Jacob HJ, Cowley Jr AW. Efficient transgenic rat production by a lentiviral vector. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H881-94.
PMID: 17322424.
161.
Broeckel U, Hengstenberg C, Mayer B, Maresso K, Gaudet D, Seda O, Tremblay J, Homer S.
Erdmann J, Glockner C, Harrison M, Martin LJ, Willias JT, Schmitz G, Riegger GA, Jacob HJ,
Hamet P, Schunkert H. A locus on chromosome 10 influences C-reactive protein levels in two independent populations. Hum Genet. 2007 Aug;122(1):95-102. PMID: 17530289.
162.
Moreno C, Kaldunski ML, Wang T, Roman RJ, Greene AS, Lazar J, Jacob HJ, Cowley AW Jr.
Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat. Physiol Genomics. 2007 Oct 22;31(2):228-35. PMID:
17566075.
163.
Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Cowley Jr AW, Jacob HJ.
Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats.
Am J Physiol Renal Physiol. 2007 Dec;293(6):F1905-14. PMID: 17898042.
164.
Petersen MC, Lazar J, Jacob HJ, Wakatsuki T. Tissue engineering: A new frontier in physiological genomics. Physiol Genomics. 2007 Dec 19;32(1):28-32. PMID: 17956999.
165.
Moreno C, Lazar J. Jacob HJ, Kwitek AE. Comparative genomics for detecting human disease genes. Adv Genet. 2008;60:655-97. PMID: 18358336.
166.
Gilbert S, Kwitek AE, Hubner N, Tschannen M, Jacob HJ, Sassard J, Bataillard AP. The effects of chromosome 17 on features of the metabolic syndrome in the Lyon Hypertensive
(LH) rat. Phsyiol Genomics. 2008 Apr 22 ;33(2):212-7. PMID: 18285521.
167.
Twigger SN, Pruitt KD, Fernandez-Suarez XM, Karolchik D, Worley KC, Maglott DR, Brown G,
Weinstock G, Gibbs RA, Kent J, Birney E, Jacob HJ. What everybody should know about the Rat Genome and its online resources. Nat Genet. 2008 May;40(5):523-7. PMID:
18443589 PMCID: PMC1761441.
168.
Aitman TJ, Critser JK, Cuppen E, Dominiczak A, Fernandez-Suarez XM, Flint J, Gauguier D,
Geurts A, Gould M, Harris PC, Holmdah R, Hubner N, Izsvak Z, Jacob HJ, Kuramoto T,
Kwitek AE, Marrone A, Mashimo T, Moreno C, Mullins J, Mullins L, Olsson T, Pravenec M,
Riley L, Saar K, Serikawa T, Shull JD, Szpirer C, Twigger SN, Voigt B, Worley K. Progress and prospects in rat genetics: a community view. Nat Genet. 2008 May;40(5):516-22.
PMID: 18443588.
169.
Guryev V, Saar K, Adamovic T, Verheul M, van Heesch SA, Cook S, Pravenec M, Aitman T,
Jacob HJ, Shull JD. Distribution and functional impact of DNA copy number variation in the rat. Nat. Genet. 2008 May;40(5):538-45. PMID: 18443591.
170.
Liang M, Lee NH, Wang H, Greene AS, Kwitek AE, Kaldunski ML, Luu TV, Frank BC,
Bugenhagen S, Jacob HJ, Cowley AW Jr. Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic rats. Physiol
Genomics. 2008 Jun 12;34(1):54-64. PMID: 18430809.
171.
Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Jacob HJ, Cowley AW Jr.
Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease.Am J Physiol Renal Physiol. 2008 Sep;295(3):F837-42. Epub 2008 Jul 23.
PMID: 18653478 PMCID: PMC2536867.
42

172.
Wang T, Jacob HJ, Ghosh S, Wang X, Zeng ZB. A joint association test for multiple SNPs in genetic case-control studies. Genet Epidemiol. 2009 Feb;33(2):151-63. 2008 Sep 3. [Epub ahead of print]. PMID: 18770519 PMCID: PMC2719721.
173.
Bilusić M, Moreno C, Barreto NE, Tschannen MR, Harris EL, Porteous WK, Thompson CM,
Grigor MR, Weder A, Boerwinkle E, Hunt SC, Curb JD, Jacob HJ, Kwitek AE. Genetically
Hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension. Croat Med J. 2008 Oct;49(5):586-99. PMID: 18925692 PMCID:
PMC2582351.
174.
Williams JM, Sarkis A, Hoagland KM, Fredrich K, Ryan RP, Moreno C, Lopez B, Lazar J,
Fenoy FJ, Sharma M, Garrett MR, Jacob HJ, Roman RJ. Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury. Am J Physiol Renal Physiol.
2008 Dec;295(6):F1764-77. Epub 2008 Oct 8.. PMID: 18842817 PMCID: PMC2604826.
175.
Adamovic T, McAllister D, Rowe JJ, Wang T, Jacob HJ, Sugg SL. Genetic mapping of mammary tumor traits to rat chromosome 10 using a novel panel of consomic rats. Cancer
Genet Cytogenet. 2008 Oct;186(1):41-8. PMID: 18786441.
176.
Dwinell MR, Worthey EA, Shimoyama M, Bakir-Gungor B, Depons J, Laulederkind S, Lowry
T, Nigram R, Petri V, Smith J, Stoddard A, Twigger SN, Jacob HJ; and the RGD Team. The
Rat Genome Database 2009: variation, ontologies and pathways. Nucleic Acids Res. 2009
Jan;37(Database issue):D744-9. Epub 2008 Nov 7.. PMID: 18996890 PMCID: PMC2686558.
177.
Aneas I, Rodrigues MV, Pauletti BA, Silva GJ, Carmona R, Cardoso L, Kwitek AE, Jacob HJ,
Soler JM, Krieger JE. Congenic strains provide evidence that four mapped loci in chromosones 2,4, and 16 influence hyptersenion in the SHR. Physiol Genomics. 2009 Mar
3;37(1):52-7. Epub 2009 Jan 6. PMID: 19126752.
178.
Iannaccone PM, Jacob HJ. Rats! Dis Model Mech. 2009 May-Jun;2(5-6):206-10. PMID:
19407324 PMCID: PMC2675817.
179.
Geurts AM, Cost GJ, Freyvert Y, Zeitler B, Miller JC, Choi VM, Jenkins SS, Wood A, Cui X,
Meng X, Vincent A, Lam S, Michalkiewicz M, Schilling R, Foeckler J, Kalloway S, Weiler H,
Ménoret S, Anegon I, Davis GD, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jacob HJ,
Buelow R. Knockout rats via embryo microinjection of zinc-finger nucleases. Science. 2009
Jul 24;325(5939):433.PMID: 19628861 PMCID: PMC2831805.
180.
Shimoyama M, Hayman GT, Laulederkind SJ, Nigam R, Lowry TF, Petri V, Smith JR, Wang
SJ, Munzenmaier DH, Dwinell MR, Twigger SN, Jacob HJ; RGD Team. The rat genome database curators: who, what, where, why. PLoS Comput Biol. 2009 Nov;5(11):e1000582.
Epub 2009 Nov 26. PMID: 19956751 PMCID: PMC2775909.
181.
Beetz N, Harrison MD, Brede M, Zong X, Urbanski MJ, Sietmann A, Kaufling J, Barrot M,
Seeliger MW, Vieira-Coelho MA, Hamet P, Gaudet D, Seda O, Tremblay J, Kotchen TA,
Kaldunski M, Nüsing R, Szabo B, Jacob HJ, Cowley AW Jr, Biel M, Stoll M, Lohse MJ,
Broeckel U, Hein L. Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. J Clin Invest. 2009 Dec;119(12):3597-3612.PMID:
19959875 PMCID: PMC2786789..
182.
Lu L, Li P, Yang C, Kurth T, Misale M, Skelton MM, Moreno C, Roman RJ, Greene AS, Jacob
HJ, Lazar J, Liang M, Cowley Jr AW. Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertension. Physiol
Genomics. [Epub ahead of print]PMID: 20009007. PMCID: PMC2841498.
183.
Adamovic Tatjana, McAllister Donna , Guryev Victor , Wang Xujing, Wendt Andrae Jaime,
Cuppen Edwin, Jacob HJ, and Sugg Sonia L. Microalterations of inherently unstable genomic regions in rat mammary carcinomas as revealed by long oligonucleotide array
Comparative Genomic Hybridization. Cancer Research. 2009 Jun 15;69(12):5159-67. Epub
2009 Jun 9. PMID: 19509235.
184.
Gaudet P, Chisholm R, Berardini T, Dimmer E, Engel SR, Fey P, Hill DP, Howe D, Hu JC,
Huntley R, Khodiyar VK, Kishore R, Li D, Lovering RC, McCarthy F, Ni L, Petri V, Siegele DA,
43

Tweedie S, Van Auken K, Wood V, Basu S, Carbon S, Dolan M, Mungall CJ, Dolinski K,
Thomas P, Ashburner M, Blake JA, Cherry JM, Lewis SE, Balakrishnan R, Christie KR,
Costanzo MC, Deegan J, Diehl AD, Drabkin H, Fisk DG, Harris M, Hirschman JE. Hong EL,
Ireland A, Lomax J, Nashs RS, Park J, Sitnikov D, Skrzypek MS, Apweiler R, Bult C, Eppig J,
Jacob HJ, Parkhill J, Rhee S, Ringwald M, Sternberg P, Talmud P, Twigger S, Westerfield M.
The Gene Ontology’s Reference Genome Project: a unified framework for functional annotation across species. PLoS Comput Biol. 2009 July; 5(7):e1000431. Eput 2009 Jul 3.
PMID: 19578431 PMCID: PMC2699109.
185.
Nobrega Marcelo A., Solberg Woods Leah C, Fleming Stewart, and Jacob HJ. Distinct genetic regulation of the progression of diabetes and renal disease in the Goto-Kakizaki (GK) rat. Physiological Genomics. 2009 Sep 9;39(1):38-46. Epub 2009 Jul 7. PMID: 19584172.
186.
MGC Project Team, Temple G, Gerhard DS, Rasooly R, Feingold EA, Good PJ, Robinson C,
Mandich A, Derge JG, Lewis J, Shoaf D, Collins FS, Jang W, Wagner L, Shenmen CM,
Misquitta L, Schaefer CF, Buetow KH, Bonner TI, Yankie L, Ward M, Phan L, Astashyn A,
Brown G, Farrell C, Hart J, Landrum M, Maidak BL, Murphy M, Murphy T, Rajput B, Riddick
L, Webb D, Weber J, Wu W, Pruitt KD, Maglott D, Siepel A, Brejova B, Diekhans M, Harte R,
Baertsch R, Kent J, Haussler D, Brent M, Langton L, Comstock CL, Stevens M, Wei C, van
Baren MJ, Salehi-Ashtiani K, Murray RR, Ghamsari L, Mello E, Lin C, Pennacchio C, Schreiber
K, Shapiro N, Marsh A, Pardes E, Moore T, Lebeau A, Muratet M, Simmons B, Kloske D, Sieja
S, Hudson J, Sethupathy P, Brownstein M, Bhat N, Lazar J, Jacob HJ, Gruber CE, Smith MR,
McPherson J, Garcia AM, Gunaratne PH, Wu J, Muzny D, Gibbs RA, Young AC, Bouffard GG,
Blakesley RW, Mullikin J, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J,
Myers RM, Hirst M, Zeng T, Tse K, Moksa M, Deng M, Ma K, Mah D, Pang J, Taylor G, Chuah
E, Deng A, Fichter K, Go A, Lee S, Wang J, Griffith M, Morin R, Moore RA, Mayo M, Munro S,
Wagner S, Jones SJ, Holt RA, Marra MA, Lu S, Yang S, Hartigan J, Graf M, Wagner R,
Letovksy S, Pulido JC, Robison K, Esposito D, Hartley J, Wall VE, Hopkins RF, Ohara O,
Wiemann S. The completion of the Mammalian Gene Collection (MGC). Genome Res. 2009
Dec;19(12):2324-33. PMID: 19767417.
187.
Geurts AM, Cost GJ, Rémy S, Cui X, Tesson L, Usal C, Ménoret S, Jacob HJ, Anegon I,
Buelow R. Generation of gene-specific mutated rats using zinc-finger nucleases. Methods
Mol Biol. 2010;597:211-25.PMID: 20013236.
188.
Jacob, HJ. The Rat: A Model Used in Biomedical Research. Humana Press, Inc. Rat
Genomics: gene identification, functional genomics and model applications. Ignacio Anegon
(Ed).
Methods Mol Biol. 2010;597:1-11. PMID: 20013222.
189.
Worthey, EA., Stoddard, A.J., Jacob, HJ., Sequencing of the rat genome and data bases.
Humana Press, Inc. Rat Genomics: gene identification, functional genomics and model applications. Ignacio Anegon (Ed). Methods Mol Biol. 2010;597:33-53.PMID: 20013224.
190.
Carlson DF, Geurts AM, Park CW, Rangel-Filho A, O’Grady SM, Jacob HJ, Steer CJ,
Largaespada DA, Fahrenkrug SC: Efficient mammalian germline transgenesis by enhanced
Sleeping Beauty transposition. Transgenic Research. Mar 30, 2010. [Epub ahead of print].PMID: 20352328.
191.
Yang Yi, Dahly-Vernon Annette J, Blomme Eric AG, Lai-Zhang Jie, Kempf Dale J, Marsh
Kennan C, Harrington Yvette A, Nye Steven H, Evans Darin L, Roman Richard J, Jacob,
HJ, Waring Jeffrey F. Liver transcriptomic changes associated with ritonavir-induced hyperlipidemia in sensitive and resistant strains of rats. Vet J. 2010 Jul: 185(1):75-82.
Epub 2010 May 23. PMID: 20547082.
192.
Shao H, Sinasac DS, Burrage LC, Hodges CA, Supelak PJ, Palmert MR, Moreno C, Cowley
AW Jr, Jacob HJ, Nadeau JH. Analyzing complex traits with congenic strains. Mamm
Genome June 2010. PMID: 2052400.
44

193.
Jacob HJ, Lazar J, Dwinell MR, Moreno C, Geurts AM. Gene targeting in the rat: advances and opportunities. Trends Genet 2010 September 23. PMID 20869786. PMCID:
PMC2991520.
194.
Adamovic T, McAllister D, Wang T, Adamovic D, Rowe JJ, Moreno C, Lazar J, Jacob HJ,
Sugg SL. Identification of novel carcinogen-mediated mammary tumor susceptibility loci in the rat using the chromosome substitution technique. Genes Chromosomes Cancer. 2010.
Nov; 49(11):1035-45. PMID: 20737482.
195.
O'Meara CC, Lazar J, Hoffman M, Moreno C, Jacob HJ. Refined Mapping of the Renal
Failure Rf-3 Quantitative Trait Locus. J Am Soc Nephrol. 2010 Dec 2. PMID: 21127141.
PMCID: PMC3060445.
196.
Worthey EA, Mayer AN, Syverson GD, Helbling D, Bonacci BB, Decker B, Serpe JM, Dasu
T, Tschannen MR, Veith RL, Basehore MJ, Broeckel U, Tomita-Mitchell A, Casper JT,
Margolis DA, Bick DP, Hessner MJ, Routes JM, Verbsky JW, Jacob HJ, Dimmock DP.
Making a definitive diagnosis: Successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease. Genet Med. 2010 Dec 17. [Epub ahead of print].
PMID: 21173700.
197.
Mayer, A.N., Dimmock, D.P., Arca, M.J., Bick, D.P., Verbsky, J.W., Worthey, E.A., Jacob,
HJ, Margolis, D.A. A timely arrival for genomic medicine, Dec. 10, 2010. Gen Med, In
Press. [Epub ahead of print]. PMID: 21169843.
198.
Shimoyama, M, Smith J.R., Hayman T, Laulederkind S, Lowry T, Nigam R, Petri V, Wang
S-J, Dwinell M, Jacob HJ and RGD Team, RGD: A Comparative Genomics Platform,
Human Genomics, Jan1; 5(2), pg 124-129, 2011. PMID: 21296746. PMCID: PMC3222152.
199.
Moreno C, Williams J, Lu Li, Liang M, Lazar J, Jacob HJ, Cowley Jr. A and Roman RJ.
Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-
13BN congenic strains. Am J Physiol Heart Circ Physiol 2011 Jan 28 (Epub ahead of print).
PMID: 21257920.
200.
Moreno C, Hoffman M, Stodola TJ, Didier DN, Lazar J, Geurts AM, North PE, Jacob HJ,
Green AS. Creation and characterization of a Renin knockout rat. Hypertension 2011 Mar;
57(3):614-9. Epub 2011 Jan 17. PMID: 21242461
201.
Williams, JM, Burke, M, Lazar J, Jacob HJ, Roman RJ: Temporal characterization of the development of renal injury in FHH rats and FHH.1BN congenic strains. Am J. Physiol
Renal Physiol 2011 (Epub ahead of print). PMID: 21048028.
202.
203.
He C, Weeks DE, Buyske S, Abecasis GR, Stewart WC, Matise TC; The Enhanced Map
Consortium. Enhanced genetic maps from family-based disease studies: populationspecific comparisons. BMC Med Genet. 2011 Jan 19;12(1):15. PMID: 21247494 [PubMed - as supplied by publisher PMID: 21247494 PMCID: PMC3037840.
Laulederkind SJ, Shimoyama M, Hayman GT, Lowry TF, Nigam R, Petri V, Smith JR, Wang
SJ, de Pons J, Kowalski G, Liu W, Rood W, Munzenmaier DH, Dwinell MR, Twigger SN,
Jacob HJ; RGD team. The Rat Genome Database curation tool suite; a set of optimized software tools enabling efficient acquisition, organization, and presentation of biological
204.
data. Database (Oxford). 2011 Feb 14; 2011. PMID: 21321022 PMCID: PMC3041158.
Petri, V, Shimoyama M, Hayman GT, Smith JR. Tutaj M, de Pons J, Dwinell MR,
Munzenmaier DH, Twigger SN, Jacob HJ; RGD Team. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8; 2011. PMID: 21478484 PMCID: PMC3072770.
205.
Stodola TJ, Monteiro de Resende M, Sarkis AB, Didier DN, Jacob HJ, Huebner H, Hummel
O, Saar K, Moreno C, Greene AS. Characterization of the genomic structure and function of regions influencing renin and angiogenesis in the SS rat. Physiol. Genomics April 26,
2011; published ahead of print April 26, 2011. PMID: 21521778.
206.
McDermott-Roe C, Ye J, Ahmed R, Sun XM, Serafín A, Ware J, Bottolo L, Muckett P, Cañas
X Zhang J, Rowe GC, Buchan R, Lu H, Braithwaite A, Mancini M, Hauton D, Martí R,
García-Arumí E, Hubner N, Jacob HJ, Serikawa T, Zidek V, Papousek F, Kolar F, Cardona
45

M, Ruiz-Meana M, García-Dorado D, Comella JX, Felkin LE, Barton PJ, Arany Z, Pravenec
M, Petretto E, Sanchis D, Cook SA. Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function. Nature. 2011 Oct 5;478(7367):114-8.
207.
O’Meara CC, Lutz MM, Sarkis AB, Xu H, Kothinti RK, Hoffman M, Moreno C, Tabatabai NM,
Lazar J, Roman RJ, Jacob HJ. A 4.1-Mb Congenic Region of Rf-4 Contributes to
Glomerular Permeability. J Am Soc Nephrol. 2012 Feb 16. [Epub ahead of print]. PMID
22343117
208.
Green RC, Berg JS, Berry GT, Biesecker LG, Dimmock DD, Evans JP, Grody WW, Hegde
MR, Kalia S, Korf BR, Krantz I, McGuire AL, Miller DTR, Murray MF, Nussbaum RL, Plon SE,
Rehm HL, Jacob HJ. Exploring concordance and discordance for return of incidental findings from clinical sequencing. Genetics in Medicine Published online 15 March 2012.
209.
Laulederkind SJ, Tutaj M, Shimoyama M, Hayman GT, Lowry TF, Nigam R, Petri V, Smith
JR, Wang SJ, de Pons J, Dwinell MR, Jacob HJ. Ontology searching and browsing at the
Rat Genome Database. Database (Oxford). 2012 Mar 20;2012:bas016. Print 2012. PMID:
22434847 PMCID: PMC3308169.
210.
Williams JM, Fan F, Murphy SR, Schreck C, Lazar J, Jacob HJ, Roman RJ.
Role of 20-
HETE in the antihypertensive effect of transfer of chromosome 5 from Brown Norway to
Dahl Salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol. 2012 Mar 21. [Epub ahead of print]. PMID: 22442195.
Submitted and/or In Press:
1.
Flister MJ, Zheng S, Sarkis AB, O’Meara CC, Hoffman M, Moreno C, Lazar J, Jacob HJ
Identification of Hypertension Susceptibility Loci on Rat Chromosome 12. Submitted to
Hypertension.
Proceedings of Meetings:
1. Pan S, Meyers G, Jacob HJ, Lewis S, Brody MJ. Non-stationary fluctuations of arterial pressure in sino-aotic deafferented rats. Proceedings of the 10
EMBS. New Orleans, 1988:135-6. th annual meeting for IEEE
2. Van Zutphen LFM, Otsen M, den Bieman M, van Lith HA, Jacob HJ, Bender. The value of microsatellites for the characterization and genetic monitoring of rat inbred strains. Proceedings of the 5 th FELASA Symposium. Brighton, UK 1993 Jun;179-182.
3. Roman RJ, Cowley, Jr. AW, Greene A, Kwitek AE, Tonellato PJ, Jacob HJ. The Cardiovascular
System, Consomic rats for the identification of genes and pathways underlying cardiovascular disease. Cold Spring Harbor Symposium on Quantitative Biology, Cold Spring Harbor Press,
2003.
Books & Chapters:
1. Jacob HJ, Krieger JE, Dzau VJ, Lander ES. Genetic Dissection of Hypertension in
Experimental Animal Models. Mockrin S (Ed): Molecular Genetics and Gene Therapy of
Cardiovascular Diseases. 1995.
2. Pettersson A, Jacob HJ, Lernmark Å. Lessons from the Animal Models: The BB Rat. Jerry P.
Palmer (Ed): Prediction, Prevention and Genetic Counseling in IDDM. 1996.
3. Koike G, Jacob HJ. Genetic Analysis of Hypertension. Textbook of Molecular Medicine.
Jameson J.L. (Eds.): Humana Press. 1997.
4. Kwitek-Black AE, Jacob HJ. Gene-Environment Interactions in Hypertension Primer: The
Essentials of High Blood Pressure. Izzo and Black (Sr. Eds): American Heart Association.
1999.
46

5. Kyengar SK, Weder AB, Koike G, Jokelainen P, Jacob HJ, Schork NJ. The Developmental
Evolution of Hypertensions: Evidence, Genetic Models, and Mechanisms. McCarthy DA, Blizard
RL, Chevalier (Eds): Elsevier Science B.V., Handbook of Hypertension Vol 19. 1999.
6. Stoll M, Jacob HJ. Improved Strategies for the Mapping of Quantitative Trait Loci in the Rat
Model. A.F. Dominiczak, J.M.C. Connell, F. Soubrier (Eds): Molecular Genetics of
Hypertension. 1999.
7. Schork, NJ, Fallin D, Thiel B, Xu X, Broeckel U, Jacob HJ, Cohen D. The Future of Genetic
Case/Control Studies. D.C. Rao and M.A. Province (Ed): Advances in Genetics/Academic Press.
2001.
8. Moreno, Jacob HJ. Integrating Biology with Rat Genomic Tools. M. Suckow (Ed): The
Laboratory Rat/Academic Press. 2004.
9. C Moreno, K Kennedy, JW Andrae, Jacob HJ. Genome Wide Scanning with SSLPs in the Rat.
J. Fennell and A.H. Baker (Eds): Humana Press, Molecular Methods in Hypertension. 2004.
10. C. Moreno, Jacob HJ, A.W. Cowley Jr. Attaching Physiology to the Genome. A.F. Dominiczak
(Ed). Elsevier Science B.V. Vol 24, 2007. Handbook of Hypertension.
Abstracts:
1. Alper RH, Jacob HJ, and Brody MJ. Humeral regulation of arterial pressure labiality in rats.
Fed Proc. 1985;44(4).
2.
Jacob HJ, Alper RH, and Brody MJ. Peripheral mechanisms regulating arterial pressure labiality in rats. Fed Proc. 1986;45(4).
3.
Jacob HJ, Machado BH, and Brody MJ. Endogenous vasoconstrictor and adrenergic mechanisms contribute to arterial pressure labiality in rats with sinoaortic deafferentation. Fed
Proc. 1987;46(4).
4.
Jacob HJ, and Brody MJ. The direct vascular action of vasoconstrictor contribute to arterial pressure labiality (APL) in sinoaortic deafferented (SAD) rats. FASEB J. 1988;2(5):A1280.
5.
Pan XG, Jacob HJ, Meyers GA, and Brody MJ. Power spectrum estimation as a tool to investigate biological feedback mechanisms. Iowa Academy of Science. 1988.
6.
Pan XG, Meyers GA, Jacob HJ, and Brody MJ. Non-stationary fluctuations of blood pressure in sinoaortic deafferented rats. IEEE EMBS. 1988.
7.
Lewis SJ, Barres C, Jacob HJ, and Brody MJ. Cardiovascular effects of an N-methyl-D-aspirate
(NMDA) receptor antagonist, MK-801 in conscious rats. Council for High Blood Pressure.
1988.
8.
Jacob HJ, Lewis SG, and Brody MJ. Does cardiac output (CO) contribute to arterial pressure labiality (APL) in sinoaortic deafferented rats? FASEB J. 1989;3(3):A851.
9.
Lewis SJ, Ohta H, Jacob HJ, and Brody MJ. Mechanisms of cardiovascular responses produced in conscious rats by kainic acid (KA) and N-methyl-D-aspirate (NMDA). FASEB J.
1989;3(3):A1146.
10.
Meyers GA, Pan S, Jacob HJ, Lewis SG, and Brody MJ. Spectral analysis demonstrates a low frequency peak involved in baroreflex regulation of arterial pressure. FASEB J.
1989;3(3):A857.
11.
Sigmund CD, Jones CA, Jacob HJ, Kim U, Dzau VJ, Gamble D, and Gross KW. Analysis of renal renin expression in renin promoter T-antigen transgenic mice. Council for High Blood
Pressure, Hypertension. 1990;16(3):P344.
12.
Jacob HJ, Sigmund CD, Jones CA, Boyounes B, McDonald J, Gross KW, and Dzau VJ. Renin and blood pressure responses of Renin promoter-SV40 T-antigen transgenic mice (TAG+) to low sodium diet. Council for High Blood Pressure, Hypertension. 1990;16(3):P345.
13.
Jacob HJ, Lander ES, and Dzau VJ. Progress towards a genetic map of the hypertensive rat.
Council for High Blood Pressure, Hypertension. 1991.
47

14.
Jacob HJ, Dzau VJ, and Lander ES. Construction of a genetic map in the spontaneously hypertensive rat. SHR Meeting, 1991. Hypertension. 1992.
15.
Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao Y, Ganten D, Dzau VJ, and
Lander ES. Genetic mapping of a gene causing hypertension in the spontaneously hypertensive rat. International Society of Hypertension. 1992.
16.
Jacob HJ, Lincoln SE, Lindpaintner K, Ganten D, and Dzau VJ. Mapping quantitative trait loci
(QTL) in the hypertensive rat. Council for High Blood Pressure, Hypertension. 1992.
17.
St. Lezin E, Wong A, Wang J-M, Pravenec M, Stec D, Jacob HJ, Roman R, Kurtz TW. Transfer of the Dahl S Renin gene into the Dahl R stain does not promote NaCl-Sensitivity and may actually cause a decrease in blood. Hypertension. 1993.
18.
Jacob HJ, Brown DM, Mao Y-P, Bunker RK, Lincoln SE, Kurtz TW, St. Lezin EM, Pravenec M,
Dzau VJ, Szpirer C, and Lander ES. Progress on Rat Genetic Linkage Map. Cold Spring Harbor
Laboratory, Genome Mapping and Sequencing Meeting. 1993.
19.
Koike G, Jacob HJ, Krieger JE, Hoehe MR, Szpirer C, Pratt RE, Dzau VJ. Is the phenylethanolamine N-methyltransferase gene in the stroke prone spontaneously hypertensive rat Bp1. Clin. Res. 1993;41:167A
20.
Krieger JE, Koike G, Franchini KG, Trolliet MR, Zangen SW, Krieger EM, Lander ES, Dzau VJ, and Jacob HJ. Genetic dissection of hypertension in the spontaneously hypertension rat
(SHR). J. Hypertension. 1994;12(suppl. 3):S66.
21.
Brown DM, Provoost AP, Daly MJ, Lander ES, and Jacob HJ: Identification of a gene responsible for renal failure in a rat model of hypertension. J. Hypertension. 1994;12(suppl.
3):S69.
22.
Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ, Goodman A, Kurtz T, Levan G, Mao YP,
Pettersson A, Pravenec M, Simon JS, St. Lezin E, Szpirer C, Szpirer J, Trolliet MR, Winer ES,
Lander ES. A genetic linkage map of the laboratory rat. The IVth Workshop of the Nordic
Genome, Helsinki. 1994.
23.
Kreutz R, Hubner N, Jacob HJ, Ganten D, Lindpaintner K. Evidence that the hypertensionassociated locus of rat chromosome 10, BP-SP1, is not identical with the angiotensinconverting enzyme gene locus. Hypertension. 1994;24:373.
24. Trolliet MR, Krieger JE, Schork NJ, Koike G, Jacob HJ. Systolic blood pressure (SBP) after salt loading is caused by 4 to 6 quanative trait loci (QTLs) acting in an additive fashion.
Hypertension. 1994;24:387.
25.
Provoost AP, Brown DM, Daly MJ Lander ES, Jacob HJ. Genetic markers responsible for renal failure and hypertension in the fawn-hooded (FHH) rat. Pediatric Nephrology.
1994;8:C43.
26.
Koike G, Horiuchi M, Yamada T, Szpirer C, Jacob HJ, and Dzau VJ. Human type 2 angiotensin in receptor gene: Cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. J. Invest. Med. 1995;43:241A.
27.
Provoost AP, Brown DM, Daly MJ, Lander ES, Jacob HJ. Identification of Rf-1, a gene responsible for renal failure in the fawn-hooded (FHH) rat. Kidney International.
1995;47:702.
28.
Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ, Goodman A, Koike G, Kren V, Kurtz T,
Lernmark Å, Levan G, Mao Y, Pettersson A, Pravenec M, Simon JS, Szpirer C, Szpirer J, Trolliet
MR, Winer ES, Lander ES. A genetic linkage map of the laboratory rat. Genome Mapping and
Sequencing, Cold Spring Harbor Laboratory. 1995 May;10-14:202.
29.
Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ. Separate genes are responsible for proteinuria and hypertension in fawn-hooded (FHH) rats. International Society of Nephrology,
Madrid. 1995;98.
30.
Simon JS, Roman RJ, Cowley AW, Greene A, Jacob HJ. Rat alpha-2 adrenergic receptor class III is linked to systolic blood pressure after salt load in genetic hypertension. Council for
High Blood Pressure Research. Hypertension. 1995;26(3),537.
48

31.
Trolliet MR, Krieger JE, Koike JE, Simon JS, Krieger EM, Dzau VJ, Jacob HJ. Gender and grandparental strain influences the genetic basis of blood pressure. Council for High Blood
Pressure Research. Hypertension 1995;26(3),537.
32.
Koike G, Horiuchi M, Winer ES, Brown DM, Dzau VJ, Jacob HJ. Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene. American Heart Association,
Circulation. 1995;92(8)suppl:1340.
33.
McLaughlin MG, Printz MP, Jacob HJ. Genetic dissection of cardiovascular startle response and hypertension in the spontaneously hypertensive Rat. American Heart Association,
Circulation. 1995;92(8)suppl:2643.
34.
Satler CA, Vesely MR, Walsh E, Wong JCL, Ginsburg GS, Jacob HJ. Mapping a gene for hereditary long QT syndrome to chromosome 7q35-36. American Heart Association,
Circulation. 1995;92(8)suppl:2073.
35.
Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ. Genetic identification of Rf-1, a gene responsible for renal failure in the fawn-hooded rat. J American Society of Nephrology.
1994;5:618.
36.
Satler CA, Plummer MH, Fan M, Zurakowski D, Walsh E, Jacob HJ, Ginsburg GS. Clinical severity increases in successive generations of familial LQT syndrome. American Heart
Association, Circulation. 1995;92(8)suppl:2473.
37.
Wong JCL, Vesely MR, Fan M, Zurakowski D, Ginsburg GS, Walsh E, Jacob HJ, Satler CA:
Genetic confirmation of a clinical diagnostic scoring system for autosomal dominant long QT syndrome (LQTS). American Heart Association, Circulation. 1995;92(8)suppl:1105.
38.
Lee JS, Adrie C, Jacob HJ, Roberts JD, Zapol WM, Bloch KD. Chronic inhalation of nitric oxide inhibits neointima formation after balloon arterial injury in rats. American Heart Association,
Circulation. 1995;92(8)suppl:3394.
39.
Knapik EW, Goodman A, Neuhauss SCF, Chiang PW, Fishman MC, Driever W, Jacob HJ. A genetic linkage map for the zebrafish (Danio rerio) consisting of simple sequence repeats.
Cold Spring Harbor Laboratory, Zebrafish Development and Genetics. 1996 Apr;24-28.
40.
Knapik EW, Goodman A, Atkinson OS, Roberts CT, Shiozawa M, Sim CU, Weksler-Zangen S,
Trolliet MR, Futrell C, Innes BA, Koike G, McLaughlin MG, Pierre L, Simon JS, Vilallonga E, Roy
M, Chiang PW, Fishman MC, Driever W, Jacob HJ. A reference cross DNA panel for zebrafish
(Danio rerio) anchored with simple sequence length polymorphism. Cold Spring Harbor
Laboratory, Zebrafish Development and Genetics. 1996 Apr;24-28.
41.
Neuhauss SCF, Solnica-Krezel L, Schier AF, Zwartkruis F, Stemple DL, Malicki J, Abdelilah S,
Stanier DYR, Mountcastle-Shah, Knapik E, Jacob HJ, Driever W. Mutations affecting craniofacial development in zebrafish. Cold Spring Harbor Laboratory, Zebrafish Development and Genetics. 1996 Apr;24-28.
42.
Knapik EW, Goodman A, Atkinson OS, Roberts CT, Shiozawa M, Sim CU, Weksler-Zangen S,
Trolliet MR, Rutrell C, Innes BA, Koike G, McLaughlin MG, Pierre L, Simon JS, Vilallonga E, Roy
M, Chiang PW, Fishman MC, Driever W, Jacob HJ. A genetic linkage map with simple sequence length polymorphisms and a reference cross for zebrafish (Danio rerio). Heidelberg,
Human Genome Meeting. 1996 Mar;22-24.
43.
Knapik EW, Goodman A, Atkinson OS, Roberts CT, Shiozawa M, Sim CU, Weksler-Zangen S,
Trolliet MR, Rutrell C, Innes BA, Koike G, McLaughlin MG, Pierre L, Simon JS, Vilallonga E, Roy
M, Chiang PW, Fishman MC, Driever W, Jacob HJ. A genetic linkage map with simple sequence length polymorphisms and a reference cross for zebrafish (Danio rerio). Cold Spring
Harbor Laboratory, Genome Mapping and Sequencing. 1996 May;8-12.
44.
Jacob Lab, Cowley Lab, Dzau Lab, Grigor Lab, Fanestil Lab, Harrap Lab, Harris Lab, Krieger
E.M. Lab, Lander Lab, Printz Lab, Provoost Lab, Roman Lab, Sassard Lab, Schork Lab, Vincent
Lab. Results from an international collaboration to map the genes responsible for high blood pressure in the rat. Sixteenth Scientific Meeting of the International Society of Hypertension.
1996 Jun;23-27 Glasgow:2B.5.
49

45.
Koike G, Horiuchi, Winer ES, Krieger JE, Dzau VJ, Jacob HJ. Investigation of candidate genes for genetic hypertension in rat. Sixteenth Scientific Meeting of the International Society of Hypertension. 1996 Jun;23-27 Glasgow:36.C.
46.
Harris EL, Koike G, Thompson CM, Porteous WK, Jacob HJ, Grigor MR. Mapping quantitative trait lici (QTL) on chromosome 2 in the New Zealand genetically hypertensive (GH) rat.
Sixteenth Scientific Meeting of the International Society of Hypertension. 1996 Jun;23-27
Glasgow:P12.
47.
Innes BA, McLaughlin MG, Kapuscinski MK, Jacob HJ, Harrap SB. Molecular genetic analysis of hypertension and ventricular mass in an experimental model of hypertension. Sixteenth
Scientific Meeting of the International Society of Hypertension. 1996 Jun;23-27 Glasgow:P48.
48.
Koike G, Harris EL, Shiozawa M, McLaughlin MG, Jacob HJ, Grigor MR. Independent genetic contributions to cardiac hypertrophy and hypertension in the New Zealand genetically hypertensive rat. Sixteenth Scientific Meeting of the International Society of Hypertension.
1996 Jun;23-27 Glasgow:P65.
49.
Koike G, Pettersson A, Daly MJ, Szpirer C, Lander ES, Lernmark Å, Fuks A, Jacob HJ. Genetic identification of novel locus Iddm3
modifies susceptibility to insulin dependent diabetes mellitus (IDDM) in the BB rat, an animal model for human IDDM. The American Journal of
Human Genetics. 1996;59:1285.
50.
Thiel B, St. Jean P, Jacob HJ, Schork NJ. Genome-wide allele sharing and gene mapping studies for complex quantitative trait loci. The American Journal of Human Genetics.
1996;59:1373.
51.
Jacob Lab, Cowley Lab, Dzau Lab, Grigor Lab, Fanestil Lab, Harrap Lab, Harris Lab, Krieger
EM, Krieger JE, Lander Lab, Printz Lab, Provoost Lab, Roman Lab, Sassard Lab, Schork Lab,
Vincent Lab. Results from an international collaboration to map the genes responsible for high blood pressure in the rat. American Journal of Human Genetics. 1996;59:309.
52.
Stelzner TJ, Hofmann TA, Jacob HJ, Deng AY. Genes of the endothelia family do not cosegregate with pulmonary hypertension in fawn hooded rats (FHR). International Conference,
New Orleans. 1996 May;5-11.
53.
Stelzner TJ, Hofmann TA, Brown DM, Jacob HJ. Mapping of a quantitative trait locus for pulmonary hypertension on rat chromosome 1. International Conference, New Orleans. 1996
May;5-11.
54.
Broeckel U, Kromer EP, Elssner D, Hengstenberg C, Riegger GAJ, Jacob HJ, Schunkert H.
Autosomal-dominant inheritance pattern in a family with Ebsteins-anomaly and further congenital malformations of the heart. Z. Kardiol, 86 Suppl. 2, S367:1997.
55.
Jacob HJ, Shiozawa M, Broeckel U, Brown DM, Naff B, Majewski R, Gauthier S, Kissebah A,
Provoost AP. Genetics of ESRD: Of Rat and Man? The American Society of Hypertension.
1997.
56.
Koike G, Jacob HJ, Cowley AW, Dzau VJ, Fanestil D, Grigor MR, Harrap SB, Harris EL, Krieger
EM, Lander ES, Printz MP, Provoost A, Roman RJ, Samani NJ, Sassard J, Schork NJ, Vincent M. et al. The comprehensive total genome scan to map genes responsible for high blood pressure in the rat. Experimental Biology. 1997.
57.
Freedman BI, Yu H, Sale M, Rich SS, Spray BJ, Roh BH, Jacob HJ, Bowden DW. Evaluation of the renal failure-1 (Rf-1) gene and chromosome 10 markers for linkage to end stage renal disease, (ESRD). American Society of Nephrology, San Antonio. 1997 Nov.
58.
Lange AR, Gebremedhin D, Jacob HJ, Koike G, Szpirer C, Aebly MR, Harder DR. cDNA cloning and functional expression of Maxi-K channel subunits from rat cerebral vascular smooth muscle. The International Society of Cerebral Blood Flow and Metabolism. Journal of Cerebral
Blood Flow and Metabolism. 1997;17:suppl 1.
59.
Broeckel U, Jiang J, Tonellato P, Feroah T, Jacob HJ, Miano JM. Assessing the spatial relationship between functional units of genes as a tool for defining genes from genomic
50

sequence with bioinformatics and bioassays. Genome Mapping and Sequencing Meeting, May
14-18, 1997, Cold Spring Harbor, New York.
60.
Jiang J, Jacob HJ. EbEST: Using transcript sequences to divine gene elements and assess gene expression. American Society of Human Genetics, Baltimore, MD. The American Journal of Human Genetics. 1997 Sep;61;4.
61.
Stoll M, Kwitek-Black AE, Koike G, Shiozawa M, Jacob HJ. Comparative mapping of quantitative trait loci for complex diseases. American Society of Human Genetics, Baltimore,
MD. The American Journal of Human Genetics. 1997 Sep;61;4.
62.
Kwitek-Black AE, Stoll M, Jiang J, Shiozawa M, Koike G, Jacob HJ. A novel “virtual comparative mapping strategy. American Society of Human Genetics, Baltimore, MD. The
American Journal of Human Genetics. 1997 Sep;61;4.
63.
Iyengar S, Schork NJ, Jokelainen, P, Koike G, Jacob HJ, Weder AB. The function of growth in the regulation of blood pressure: Model organisms as a paradigm for human disease.
American Society of Human Genetics, Baltimore, MD. The American Journal of Human
Genetics. 1997 Sep;61;4.
64.
Broeckel U, Tonellato P, Gauthier SA, Kissebah AH, LePain N, Jacob HJ. Screening dialysis patients for familial clustering of end-stage renal disease to determine genetic forms. J Am
Soc Nephrol, 8, 387 A, 1997.
65.
Jacob HJ, Shiozawa M, Broeckel U, Brown DM, Neff B, Majewski RR, Gauthier S, Kissebah A,
Provoost AP. Genetics of ERSD: Of rat and man? American Journal of Hypertension, 10(4), part 2, 216A, 1997.
66.
Jacob HJ, Majewski RR, Gauthier S, Broeckel U, Kissebah A, Provoost AP. Genetic susceptibility to end-stage renal disease. Nephrology, 3(Suppl. 1), S43, 1997.
67.
Broeckel U, Tonellato P, Kissebah AH, Provoost AP, Linzmeier D, LePain N, Lazarus JM, Jacob
HJ. An epidemiological analysis to determine familial clustering of end-stage renal disease.
Nephrology, Dialysis, Transplantation, 13 (6), 1998.
68.
Jacob HJ, Peiffer MM, Atkinson OS, Granados MA, Roman RJ, Cowley Jr. AW. Genome cassette system for determining genes and their function in hypertension. International
Society of Hypertension, Amsterdam. 1998 Jun;7-11.
69.
Kwitek-Black AE, Glenn CC, Matise, T, Colman SD, Mull T, Tonellato P, Kingsmore SF, Jacob
HJ. Comparativem in Silico. Genome Mapping, Sequencing & Biology, Cold Spring Harbor,
NY. 1998 May;13-17.
70.
Jacob HJ, Runte M, Peiffer MM, Mull T, Granados M, Roman RJ, Cowley AC. Consomic rats for determining genes and their function. Genome Mapping, Sequencing & Biology, Cold
Spring Harbor, NY. 1998 May 13-17.
71.
Kendziorski CM, Cowley AW, Green AS, Jacob HJ, Tonellato P. Physiologically informative quantitative trait loci. Genome Mapping, Sequencing & Biology, Cold Spring Harbor, NY. 1998
May13-17.
72.
Steen R, Russo K, Appel D, Slonim D, VanEtten W, Atkinson S, Jacob HJ, Lander E. Towards a high-density genetic map of the rat. Genome Mapping, Sequencing & Biology, Cold Spring
Harbor, NY. 1998 May 13-17.
73.
Tonellato PJ, Lu J, Xu Y, Chuan Y, Chen D, Wang Z, Jacob HJ. Gene feature prediction and sequence mining. Genome Mapping, Sequencing & Biology, Cold Spring Harbor, NY. 1998
May 13-17.
74.
Van Dokkum RPE, Provoost AP, Sun CW, Jacob HJ, Roman RJ. Impaired renal vascular responses in the fawn-hooded hypertensive (FHH) rat. Journal of the American Society of
Nephrology. 1998 Oct 25-28.
75.
Shiozawa M, Provoost AP, Majewski RR, Van Dokkum RPE, Jacob HJ. Interacting genes determine susceptibility to proteinuria after uninephrectomy in rats journal of The American
Society of Nephrology. 1998 Oct 25-28.
51

76.
Nobrega MA, Roman RJ, Jacob HJ. Susceptibility For Renal Disease In the GK rat, a model for non-insulin-dependent diabetes mellitus (NIDDM). Journal of the America Society of
Nephrology. 1998 Oct 25-28.
77.
Jacob HJ, Runte M, Peiffer MM, Mull TJ, Granados MA, Roman RJ. Consomics Rats: A platform for Physiological Genetics. Physiological Research. 1998; 5:39P.
78.
Cowley AW, Roman RJ, Greene A, Tonellato P, Jacob HJ. Chromosomal pattern of quantitative trait loci in the brown Norway and Dahl S intercross. Physiological Research.
1998;5:36P.
79.
Cowley AW, Jacob HJ, Roman RJ, Greene AS, Kaldunski M, Stoll M, Tonellato PJ. Genetic and phenotypic differences of Dahl S/MCW and Brown Norway/MCW inbred rats. The FASEB
Journal. 1999;13(4):A380.
80.
Cowley AW, Roman RJ, Greene AS, Jacob HJ, Kaldunski ML. Renal phenotypic and gender differences between Dahl S/MCW and Brown Norway/MCW rats. The FASEB Journal. 1999;13
(4):A380.
81.
Kita Y, McQuestion GD, Eick DH, Jacob HJ, Tonellato PJ, Cowley AW, Greene AS. Massively parallel analysis of gene expression using cDNA microarrays. The FASEB Journal.
1999;13(4):A381.
82.
Kwitek-Black AE, Tonellato PJ, Zhu H, Chen D, Mull T, Stoll M, Jacob HJ. An integrated mammalian genome platform for physiological genomics. The FASEB Journal.
1999;13(4):A379.
83.
Nobrega MA, Roman RJ, Fogo AB, Jacob HJ. Genetic mapping of diabetes-associated renal disease phenotypes in the GK rat, a model of spontaneous non-insulin dependent diabetes mellitus (NIDDM). The FASEB Journal. 1999;13(4):A380.
84.
Runte ML, Johnson NL, Granados MA, Roman RJ, Cowley AW, Jacob HJ. Consomic rats for determining genes and their function. The FASEB Journal. 1999;13(4):A379.
85.
Koike G, Grigor MR, Harris EL, Jacob HJ, Sassard J, et al. Implication for genetic studies of human complex diseases from results obtained in genetic in Rats. The FASEB Journal.
1999;13(4):A380.
86.
Kwitek-Black AE, Chen D, Zhu CH, Mull T, Handley J, Stoll M, Twigger S, Tonellato PJ, Jacob
HJ. Rat/human comparative maps based upon >25,000 unigene clusters. Genome
Sequencing and Biology, Cold Spring Harbor, NY. 1999 May;19-23.
87.
Stoll M, Cowley AW, Greene AS, Kaldunski ML, Roman RJ, Tonellato PJ, Wang Z, Jacob HJ.
Dissecting the Genetics of Hypertension Using Likely Determinant Phenotypes and
Pharmacogenetics. Genome Sequencing and Biology, Cold Spring Harbor, NY. 1999 May;19-
23.
88.
Broeckel U, Shiozawa M, Fallin D, Wick GS, Cooper RS, Rotimi CN, Nobrega M, Provoost AP,
Schork NJ, Jacob HJ. Comparative mapping and linkage disequilibrium of the rat RF-1 region identifies a haplotype associated with hypertensive end-stage renal disease in humans.
Genome Sequencing and Biology, Cold Spring Harbor, NY. 1999 May;19-23.
89.
Wang Z, Stoll M, Wang Y, Chen D, Lu J, Jacob HJ, Tonellato PJ. QTL annotator. Genome
Sequencing and Biology, Cold Spring Harbor, NY. 1999 May;19-23.
90.
Steen R, Kwitek-Black, Anne, Van Etten W, Appel D, Muir M, Twigger S, Mull T, Gullings-
Handley, Glenn C, Popp M, Knight J, Matise T, Brown D, Lu J, Kingsmore S, Tonellato P,
Colman S, Jacob HJ, Lander E. A high-density integrated radiation hybrid/genetic linkage
91.
map of the laboratory rat. . Genome Sequencing and Biology, Cold Spring Harbor, NY. 1999
May;19-23.
Broeckel U, Shiozawa M, Wick homologous region of rat
GS, Cooper
RS, Provoost AP, Schork NJ, Jacob HJ. The human
is associated with end-stage renal disease. European Renal
Association Annual Meeting 1999.
52

92.
Stoll M, Cowley AW, Harrap SB, Harris EL, Krieger JE, Kwitek-Black A, Printz MP, Provoost A,
Sassard J, Jacob HJ. Comparative genomics yields targets for human hypertension. Fifty-
Third Fall Conference of the HBPR Council 1999.
93.
Baker JE, Konorev EA, Gross GJ, Chilian WM, Jacob HJ. Resistance to myocardial ischemia in five rat strains: Evidence for a genetic basis for cardioprotection. Seventy-Second Scientific
Sessions, American Heart Association 1999.
94.
Nobrega MA, Roman RJ, Jacob, HJ. Genetics of progressive renal disease in the GK rat: A model for spontaneous non-insulin dependant diabetes mellitus (NIDDM). ASN 32 nd Annual
Meeting; American Society of Nephrology. 1999:10.
95.
Shiozawa M, Brown D, Naff B, Van Dokkum R, Provoost AP, Jacob HJ. Genetic and physical mapping of Rf-1 gene region on rat Chromosome 1. ASN 32 nd Annual Meeting; American
Society of Nephrology. 1999:10.
96.
Broeckel U, Shiozawa M, Fallin D, Wick GS, Cooper RS, Nobrega M, Provoost AP, Schork NJ,
Jacob HJ. Using comparative mapping of the rat Rf-1 region identifies a haplotype which is associated with human hypertensive end-stage renal disease. ASN 32 nd Annual Meeting;
American Society of Nephrology. 1999:10.
97.
Kwitek-Black AE, Steen R, Shiozawa M, Handley J, Twigger S, Lander ES, Tonellato PJ, Jacob
HJ. Building a backbone map for the rat genome. Physiological Genomics and Rat Models,
Cold Spring Harbor, NY. 1999 Dec;9–12.
98.
Cowley Jr. AW, Schork NJ, Greene AS, Roman RJ, Theil B, Stoll M, Tonellato PJ, Jacob HJ.
Physiological genomics and cardiovascular profiling in the rat. Physiological Genomics and Rat
Models, Cold Spring Harbor, NY. 1999 Dec;9–12.
99.
Provoost AP, Shiozawa M, Broeckel U, Filho AR, Brown D, Nobrega MA, Jacob HJ. Genetic
Mapping Of RF-1 Gene On The Fawn-Hooded Hypertensive Rat. Physiological Genomics and
Rat Models, Cold Spring Harbor, NY. 1999 Dec;9–12.
100.
Baker JE, Konorev EA, Gross GJ, Chilian WM, Jacob HJ. Resistance to myocardial ischemia in five rat strains: Is there a genetic component of cardioprotection? Physiological Genomics and
Rat Models, Cold Spring Harbor, NY. 1999 Dec;9–12.
101.
Jacob HJ, Runte ML, Johnson NL, Dye T, Roman RJ, Cowley, Jr. AW. Consomic rats for rapidly determining genes and their function. Physiological Genomics and Rat Models, Cold
Spring Harbor, NY. 1999 Dec;9–12.
102.
Scheel S, Thomas M, Vater A, Schatz P, Grob U, Vicentini M, Jacob, HJ, Ganten D, Knoblauch
M. Establishment of a high resolution mapping cross for the rat genome. Physiological
Genomics and Rat Models, Cold Spring Harbor, NY. 1999 Dec;9–12.
103.
Twigger S, Gullings-Handley J, Kwitek-Black A, Tonellato P, Jacob HJ. ACP haplotyper and genome scanner – novel web tools for rat genomics. Physiological Genomics and Rat Models,
Cold Spring Harbor, NY. 1999 Dec;9–12.
104.
Wang Z, Stoll M, Xie X, Wang Y, Chen D, Lu J, Jacob HJ, Tonellato P. Web based quantitative trait analysis. Physiological Genomics and Rat Models, Cold Spring Harbor, NY. 1999 Dec;9–
12.
105.
Tonellato P, Twigger S, Lu J, Wang Z, Jacob HJ. The rat genome database. Physiological
Genomics and Rat Models, Cold Spring Harbor, NY. 1999 Dec;9–12.
106.
Nobrega M, Roman RJ, Jacob HJ. Genetics of progressive renal disease in the GK rat: A model for spontaneous non-insulin dependent diabetes mellitus (NIDDM). Physiological
Genomics and Rat Models, Cold Spring Harbor, NY. 1999 Dec;9–12.
107.
Nobrega MA, Roman RJ, Jacob HJ. Genetics of progressive renal disease and dislipidemia in the spontaneously diabetic GK rat. Experimental Biology. 2000.
108.
Hodges M, Forster HV, Cowley Jr. AW, Jacob, HJ, Schmidt R, Provoost AP. Differences in ventilatory response to hypoxia and hypercapnia among three inbred strains of adult rats.
Experimental Biology. 2000.
53

109.
Papanek PE, Hodges M, Forster HV, Jacob HJ, Cowley Jr. AW. Differences in ventilatory responses to graded exercise among inbred strains of adult rats. Experimental Biology. 2000.
110.
Karau K, Johnson R, Molthen R, Provoost A, Cowley A, Jacob HJ, Dawson C. Pulmonary arterial remodeling in the fawn hooded rat revealed by microfocal x-ray tomography.
Experimental Biology. 2000.Hoagland KM, Alonso-Galicia M, Fenoy FJ, Flasch AK, Jacob HJ,
Rapp J, Roman R.J. Altered blood pressure and renal function in chromosome 5 congenic Dahl salt-sensitive rats. Experimental Biology. 2000.
111.
Provoost AP, Shiozawa M, Van Dokkum RPE, Jacob HJ. Congenic rat strains to investigate the genetics of renal damage after unilateral nephrectomy. Cambridge Health Tech. 2000.
112.
Broeckel U, MJ Rieder, B Thiel, H Schunkert, GAJ Riegger, HW Hense, A Doering, DA
Nickerson, NJ Schork, Jacob HJ. Correlation matrix analysis to determine the effect of SNP haplotypes for the Angiotensin-Converting-Enzyme (
) on cardiovascular phenotypes. Cold
Spring Harbor Genome Sequencing and Biology Meeting. 2000.
113.
Broeckel U. Shiozawa M, Fallin D, Wick GS, Cooper RS, Nobrega M, Provoost AP, Schork NJ,
Jacob HJ. The homologous region of rat Rf-1 is associated with hypertensive end-stage renal disease in African Americans. International Society of Hypertension meeting Chicago. 2000.
114.
Broeckel U, Rieder MJ, Thiel B, Schunkert H, Riegger GAJ, Hense HW, Doering A, Nickerson
DA, Schork NJ, Jacob HJ. Angiotensin-converting enzyme and cardiovascular phenotypes.
DMW, 125, Suppl 3; WS3-3, 2000.
115.
Shiozawa M, Kita Y, Majewski RR, Rangel-Filho A, Nobrega MA, Provoost A, Jacob HJ.
Identification of differentially expressed genes by cDNA microarray for end-stage renal disease in the Fawn-Hooded Rat. ASN 33 rd Annual Meeting. 2000.
116.
Broeckel U, Kephart DD, Feldmann MM, Shiozawa M, Jacob HJ, Schifreen R. Testing
READIT™, a novel, SNP typing assay for it’s use in a high throughput association mapping study. Twelfth International Genome Sequencing and Analysis Conference September 12-15, ,
2000. The Institute for Genomic Research. Miami Beach, FL.
117.
Jacob HJ, Kita Y, Kwitek-Black A, Shiozawa M. Functional genomics for drug discovery.
International Mammalian Genome Society. November 2000.
118.
Jacob HJ. Modern genetic mapping approaches in laboratory animals/rats. Journal of
Experimental Animal Science. 2000;41:32-34.
119.
Takahiro Ueno, Johanne Tremblay, Univ of Montreal, Montreal, PQ Canada; Jaroslave Kunes,
Josef Zicha, Zdenak Dobesova, Academy of Sciences of the Czech Republic, Prague, Czech
Republic; Zdenka Pausova, Alan Y Deng, Yu-Lin Sun, Univ of Montreal, Montreal, PQ Canada;
Jacob HJ, Medical College of Wisconsin, Milwaukee, WI; Pavel Hamet, Univ of Montreal,
Montreal, PQ Canada. Balance of negatively and positively associated loci may protect from cardiac hypertrophy and renal atrophy in hypertension. American Heart Association 55 th
Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research.
2001 abstract# 100371.
120.
Lemanski, Jr. Robert F., Mikus Lance D., Tuffaha Amjad, Sorkness Ronald L., Cowley, Jr. Allen
W., Jacob HJ and Rosenthal Louis A. Chromosomal substitutions between rat strains with Th1- or Ths2- biased responses: A novel strategy for physiogenomic studies of allergic inflammation. University of Wisconsin Medical School and University of Wisconsin School of
Pharmacy. 2002.
121.
Rafiee Parvaneh, Shi Yang, Heidemann Jan, Jacob HJ, Lazar Jozef and Baker John E.
Functional proteomic analysis: Evidence for cardioprotective proteins in the Brown Norway Vs.
Dahl S rat. American Heart Association. 2002.
122.
Moreno Carol, Ryan Robert P, Jene Sheri, Kennedy Kathleen, Jeffrey V Eckert, Jacob HJ,
Abraham P Provoost and Richard J Roman. Impaired autoregulation of renal blood flow is linked to the Rf-1 region in the Fawn-Hooded rat. American Society of Nephrology. 2002.
54

123.
Moreno C, Dumas P, Stoll M, Greene AS, Kaldunski ML, Roman RJ, Tonellato PJ, Wang Z,
Jacob HJ, Cowley AW. “Gender differences in the genetic determinants of hypertension”.
Council for High Blood Pressure Reseach. September 2002.
124.
Moreno C, Ryan RP, Jene S, Kennedy K, Eckert JV, Jacob HJ, Provoost AP, Roman RJ.
“Impaired autoregulation of renal blood flow is linked to the Rf-1 region in the Fawn-hooded
rat”. American Society of Nephrology. October 2002.
125.
Ali I, Jacob HJ, Hessner M, Hogan W, Rittmann T, Shaker R, MCW Dysphagia Institute,
Division of Gastroenterology and Hepatology and the Human and Molecular Genetics
Center. Regional differences in normal esophageal mucosal gene expression profiles in healthy controls, esophagitis and Barrett’s patients. Medical College of Wisconsin, Milwaukee,
WI. December 2002.
126.
Moreno C, Tadisch GM, Meinecke BJ, M.L.Kaldunski, Jacob HJ, A.W.Cowley. “Genetics of
Salt-Sensitive Hypertension. Genetic linkage and Congenic Development from the Consomic
SS.BN.13 Rat”. APS Conference: Understanding Renal and Cardiovascular Function Through
Physiological Genomics. October 2003.
127.
Moreno C, Khan S, Jiang N, Lazar J, Tschannen M, Jensen-Seaman M, Tackes J, Jene S,
Hessner M, Jacob HJ “Microarray analysis of gene expression changes in the kidney of the
Rf-1 congenic strain of the Fawn-Hooded rat”. Rat genetics Symposium. Cold Spring Harbor.
December 2003.
128.
Baessler A, Reinhard W, Hasinoff M, Sonnenberg G, Olivier M, Fischer M, Erdmann J,
Schunkert H, Doering A, Jacob HJ, Comuzzie AG, Kissebah A, Kwitek AE. Genetic linkage and association of the ghrelin receptor gene in human obesity. The Biology of Genomes,
Cold Spring Harbor, NY, May 2004.
129.
Bilusic M, Barreto NE, Tschannen MR, Harris EL, Jene SA, Jacob HJ, Kwitek AE. Congenic
BN.GH2 ñ normotensive strain despite increased vasopressor sensitivity and T3 level. The
FASEB Journal, 18, #6765, 2004.
130.
Lopez B, Moreno C, Ryan R, Jene S, Kennedy K, Eckert J, Jacob HJ, Provoost AP, Roman RJ.
La region Rf-1 del cromosoma 1 contribuye al desarrollo de la enfermedad glomerular en las ratas Fawn-Hooded”. 9ª Reunión Nacional. Sociedad Española de Hipertensión. Liga
Española para la lucha contra la Hipertensión Arterial. 2004. Hipertensión.
131.
Lopez B, Ryan RP, Moreno C, Lazar J, Jacob HJ, Provoost AP and Roman RJ. Identification of a QTL on region of chromosome 1 for impaired autoregulation of RBF in Fawn-Hooded
Hypertensive rats. Council of High Blood Pressure Research. September 2004.
132.
Lutz MM, Andrae JW, Sharma M, Lazar J, Moreno C, Provoost AP, Jacob HJ. Focusing in on
Rf-4: The Use of Subcongenic Rat Strains To Narrow the Region of CHR. 14 Involved in
Hypertensive Renal Failure. American Society of Nephrology. October 2004.
133.
Moreno C, Khan S, Jiang N, Jensen-Seaman M, Lazar J, Provoost A, Hessner MJ, Jacob HJ.
Patron temporal de expresión genetica en el rinon de la rata congenica ACI.FHH.RF-1”. 9ª
Reunión Nacional. Sociedad Española de Hipertensión. Liga Española para la lucha contra la
Hipertensión Arterial. 2004. Hipertensión.
134.
Moreno C, Kaldunski ML, Lazar J, Roman RJ, Greene AS, Jacob HJ, Cowley AW.
Identificación de un locus de hipertensión sal-sensible mediante el uso de lincage genetico en ratas consomicas. 9ª Reunión Nacional. Sociedad Española de Hipertensión. Liga Española para la lucha contra la Hipertensión Arterial. 2004. Hipertensión.
135.
Moreno C, Khan S, Jiang N, Lazar J, Tschannen M, Jensen-Seaman MI, Provoost A, Hessner
MJ, Jacob HJ. Temporal patterns of gene expression in the kidney of the
congenic rat strain. American Society of Nephrology. October 2004.
136.
Moreno C, Khampang P, Schippers D, Lazar J, Kaldunski ML, Greene AS, Roman RJ, Jacob
HJ, Cowley AW. Expresión renal y secuencia comparativa de la ciclooxigenasa-2 en hipertensión sal-sensible. 9ª Reunión Nacional. Sociedad Española de Hipertensión. Liga
Española para la lucha contra la Hipertensión Arterial. 2004. Hipertensión.
55

137.
Moreno C, Khampang P, Schippers D, Lazar J, Kaldunski ML, Greene AS, Roman RJ, Kwitek
AE, Jacob HJ, Cowley AW. Renal expression and sequence comparison of cyclooxygenase 2 in salt-sensitive hypertension. Experimental Biology 2004. FASEB Journal.
138.
Moreno C, Kaldunski ML, Lazar J, RJ Roman, Greene AS, Jacob HJ, Cowley AW. Efectos de los inhibidores del citocromo P450 y de un antagonista del 20-HETE sobre la funcion renal en ratas”. 9ª Reunión Nacional. Sociedad Española de Hipertensión. Liga Española para la lucha contra la Hipertensión Arterial. 2004. Hipertensión.
139.
Wang, X, Jia S, Jiang N, Chen M, Meyer M, Moreno-Quinn C, Jacob HJ, Ghosh S, Hessner
MJ. MCW microarray QC platform: a pathway to quantitative and sensitive gene expression profiling. MGED 7 Meeting of the Microarray Gene Expression Data Society. September 8-10,
2004. Toronto, CA, 2004.
140.
Moreno C, Khampang P, Schippers D, Lazar J, Kaldunski ML, Greene AS, Roman RJ, Kwitek
AE, Jacob HJ, Cowley,Jr AW. Human and Molecular Genetics Center. Department of
Physiology. Department of Dermatology. Medical College of Wisconsin, Milwaukee WI.
Renal expression and sequence comparison of Cyclooxygenase 2 in salt-sensitive hypertension. Experimental Biology 2004.
141.
Moreno C, Lazar J, Khan S, Wen X, Jiang N, Tschannen MI, Chen M, Provoost A, Hessner
MJ, Lazar J, Jacob HJ. Temporal patterns of gene expression during the development of renal failure. ASN October 2004, St. Louis, JASN 15: 434A.
142.
Sharma CM, Lazar J, Lutz M, Barreto N, Andrae JW, Moreno C, van Dijk S, Provoost AP,
McCarthy ET, Savin VJ, Jacob HJ. In Vitro Glomerular Albumin Permeability (Palb) as an
Early Phenotypic Marker of Renal Injury. American Society of Nephrology. October 2004.
143.
Strohl KP, Moreno C, Lazar J, Tschannen M, Erokwu B, Feroah T, Jacob HJ. A Genome-
Wide Scan for Respiratory Frequency in Male Rats. American Thoracic Society. 2004.
144.
Van Dijk, SJ., Specht, PA, Lazar, J, Jacob, HJ, Provoost, AP. Increased susceptibility to renal damage and impaired autoregulation in R
R
, and R
congenic rats compared to ACI and rats. American Society of Nephorlogy. October 2004, St. Louis, JASN 15: 207A.
145.
Van Dijk, SJ, Specht, PA, Lazar, J, Jacob, HJ, Provoost, AP. Remant kidney: A not so good model to compare the susceptibility to renal damage in congenic rats? American Society of
Nephrology. October 2004, St. Louis, JASN 15: 828A.
146.
Sarkis A, Lopez B, Hoagland KM, Moreno C, Fenoy FJ, Lazar J, Jacob HJ, Kwitek AE, Garrett
MR, Rapp JP and Roman RJ. Transfer of the CYP4A region from Lewis rats into Dahl S background reduces renal injury. Council of High Blood Pressure Research. October 2005.
147.
Strohl KP, Moreno C, Lazar J, Tschannen M, Erokwu B and Jacob HJ. A genome scan for breathing frequency in Sprague Dawley and Brown Norway rats. Cold Spring Harbor
Laboratory. Cold Spring Harbor, NY. December 2005.
148.
Moreno C, Andrae JW, Lutz M, Orlebeke K, Lazar J, Greene AS, Twigger SN and Jacob HJ.
Concordance of allele characterization project data with SNP distribution across rat strains.
Cold Spring Harbor Laboratory. Cold Spring Harbor, NY. December 2005.
149.
Majewski RR, Lazar J, Hessner M, Moreno C, Kwitek AE, Jurinic A, Lemke A, Wendt-Andrae J and Jacob HJ. High-throughput production of rat knockout models for hypertension using
ENU mutagenesis and tilling assay. Rat Genomics and Models Symposium. Cold Spring
Harbor Laboratory. Cold Spring Harbor, NY. December 2005.
150.
Schlick NE, Lazar J, Stekiel TA, Contney SJ, Bosnjak ZJ, Jacob HJ. The role of mitochondrial
DNA and mitochondrial function in the onset and progression of diabetic nephropathy. Cold
Spring Harbor Laboratory. Cold Spring Harbor, NY. December 2005.
151.
Rangel-Filho A, Datta Y, Provoost A, Lazar J, Jacob HJ. Renal disease, coat color, platelet function and alcohol intake are modulated by the
locus in the Fawn-Hooded Rat. Cold
Spring Harbor Laboratory. Cold Spring Harbor, NY. December 2005.
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152.
Lutz MM, Lazar J, Sharma M, Moreno C, Andrae J.W, Provoost AP, and Jacob HJ Sequence and gene expression comparison in a narrowed region of congenic rats. Cold Spring Harbor Laboratory. Cold Spring Harbor, NY. December 2005.
153.
Moreno C, Kaldunski ML, Wang T, Lazar J, Roman RJ, Greene AS, Jacob HJ and Cowley Jr
AW. Existence of multiple blood pressure loci on rat chromosome 13 of the Dahl S
Hypertensive rat. FASEB/Experimental Biology. San Francisco, CA. April 2006.
154.
Lutz MM, Sharma M, Lazar J, Provoost A.P, Jacob HJ Identification of sequence and expression variants in a narrowed region of the
locus in ACI, FHH and double
locus related to renal failure.
FASEB/Experimental Biology. San Francisco, CA. April 2006.
155.
Schlick NE, Ryan RP, Roman RJ, Jacob HJ. Rf-1 implicated in the nephropathy of the T2DN rat. FASEB/Experimental Biology. San Francisco, CA. April 2006.
156.
Moreno C, Rogge R, Lazar J, Tschannen M, Kaldunski M, Cowley AW, Jacob HJ.
Characterization of blood pressure and protein excretion in chromosome 18 congenic strains of Dahl S rats. The Australian Health & Medical Research Congress. Melbourne, Australia.
December 2006.
157.
Solberg-Woods LC, Wendt-Andrae J, Tschannen M, Jacob HJ. Utility of heterogeneous stock rats for fine-mapping non-insulin dependent diabetes mellitus. The Australian Health &
Medical Research Congress. Melbourne, Australia. December 2006.
158.
Petri V, Shimoyama M, Patzer A, Kowalski G, Rood W, Laulederkind S, Reilly D, Smith J,
Kwitek A, Jacob HJ, Twigger S. Rat Genome Database development impact on GO use and
GO annotations. Gene Ontology Consortium Meeting. Cambridge, UK. January 2007.
159.
Moreno C, Shimoyama M, Chen J, Kowalski G, Laulederkind S, Li D, Nigam R, Patzer A, Petri
V, Smith J, Twigger S, Kwitek AE, Jacob HJ. The Rat Genome Database: Integrated Data
Platform. EURATools Annual Meeting. Prague, Czech Republic. February 2007.
160.
Jacob HJ, Lazar J, Rangel-Filho A, Lutz M, Sharma M, van Dijk SJ, Roman RJ, Moreno C,
Provoost A. Genetic complexity of hypertension associated renal failure. International
Society of Nephrology – Nature Genetics Forefronts Symposium on Nephrogenetics: from
Development to Physiology. Danvers, MA. March 2007.
161.
Shimoyama, M. (Poster), Patzer A, Kowalski G, Petri V, Laulederkind S, Smith J, Nigam R,
Chen J, Li D, Zuniga-Meyer A, Twigger S, Kwitek A, Jacob HJ. Disease Portals: A Platform for Genetic and Genomic Research. Cold Spring Harbor Laboratory, The Biology of Genomes.
Cold Spring Harbor, NY. May 2007.
162.
Jacob HJ, Lazar J, Angel A, Lutz M, Harma MS, Van Dijk SJ, Roman RJ, Moreno C and
Provoost AP. Genetic complexity of hypertension associated renal failure. Forefronts
Symposium on Nephrogenetics. Danvers, MA. March 2007.
163.
Moreno C, Dwinell MR, Majewski R, Kwitek AE, Hessner MJ, T.R. Feroah, H.V. Forster, D.L.
Mattson, J.H. Lombard, G.D. Mcquestion, R.J. Roman, A.S. Greene, A.W. Cowley and Jacob
HJ. High-Throughput Production and Phenotyping of Rat Knockout Models for Hypertension.
Experimental Biology. Washington, D.C. April 2007.
164.
Smith JR, Shimoyama M, Petri V, Nigam R, Laulederkind S, Reilly D, Kowalski G, Li D, Chen J,
Patzer A,Twigger S, Kwitek A, Jacob HJ. The Rat Genome Database: Biological information in a genomic context. Cold Spring Harbor Laboratory, The Biology of Genomes. Cold Spring
Harbor, NY. May 2007.
165.
Laulederkind S (Poster), Shimoyama M, Patzer A, Petri V, Smith J, Nigam R, Reilly D,
Kowalski G, Jin W, Chen J, Li D, Zuniga-Meyer A, Twigger S, Kwitek A, Jacob HJ. Disease
Portals - A platform for genetic and genomic research. HUGO's 12th Human Genome
Meeting. Montreal, Canada. May 2007.
166.
Lazar, J., Petersen, M., Michalkiewicz, M., Geurts, A., Rangel-Filho, A., Wakatsuki, T., Jacob,
HJ. High throughput phenotyping platform for positional cloning using engineered heart tissue. Cold Spring Harbor Laboratory, The Biology of Genomes. Cold Spring Harbor, NY.
May 2007.
57

167.
Aron M. Geurts, Baison Lu, Artur Rangel-Filho, Daniel F. Carlson, Scott C. Fahrenkrug, Colin
E. Bishop, David A. Largaespada, and Jacob HJ. Unlocking the rat genome with transposable elements. Firth Annual International Meeting on Transposition and Animal
Biotechnology. University of Minnesota. Minneapolis, MN. June 2007.
168.
Feroah TR, Forster HV, Merritt A, Dwinell M, Moreno C, Greene A, Jacob HJ and Cowley Jr A.
Significant differences in novel and adapted circadian movement behavior in three parental and two ENU knockout inbred strains of rats. Clinical Cardiovascular Genomics. Cold Spring
Harbor, NY. September 2007.
169.
Moreno C, Dwinell MR, Schilling RR, Kwitek AE, Greene AS, Roman RJ, Feroah TR, Forster
HV, Mattson DL, Lombard JH, McQuestion JD, Cowley AW and Jacob HJ. Production and characterization of rat knockout models for studying cardiovascular disease. Cold Spring
Harbor Laboratory. Clinical Cardiovascular Genomics. Cold Spring Harbor, NY. September
2007.
170.
Moreno C, Dwinell MR, Schilling RR, Kwitek AE, Greene AS, Roman RJ, Lazar J,Mattson DL,
Lombard JH, McQuestion GD, Cowley AW and Jacob HJ. Modeling cardiovascular disease in rat by ENU mutagenesis. 21st International Mammalian Genome Conference. Kyoto, Japan.
October 2007.
171.
Petri V, Shimoyama M, Patzer A, Kowalski G, Laulederkind S, Smith J, Nigam R, Jin W, Li D,
Zuniga-Meyer A, Twigger S, Kwitek A, Jacob HJ. Disease Portals: A platform for genetic and genomic research at the Rat Genome Database. Midwest Symposium on Computational
Biology & Bioinformatics 1st Annual MSCBB. Northwestern University, Evanston, IL. October
2007.
172.
Smith JR, Shimoyama M, Petri V, Nigam R, Laulederkind S, Kowalski G, Li D, Chen J, De Pons
J, Patzer A, Twigger S, Kwitek A, Jacob HJ. The Rat Genome Database: Automated pipelines facilitate rapid and reliable updates of genomic data. Midwest Symposium on
Computational Biology & Bioinformatics 1st Annual MSCBB. Northwestern University,
Evanston, IL. October 2007.
173.
Kowalski G, Smith J, Li D, Shimoyama M, Patzer A, Petri V, Laulederkind S, Nigam R, De Pons
J, Dwinell M, Twigger S, Jacob HJ. Automated pipelines facilitate rapid and reliable updates of genomic data. Midwest Symposium on Computational Biology & Bioinformatics 1st Annual
MSCBB. Northwestern University, Evanston, IL. October 2007.
174.
Petri V (Poster), Shimoyama M, Patzer A, Smith J, Laulederkind S, Kowalski G, Li D, Chen J,
Nigam R, Zuniga-Meyer A, Twigger S, Dwinell M, Jacob HJ. Maximizing curation and information coverage of rat genes at the Rat Genome Database. Second International
Biocurator Meeting. San Jose, CA. October 2007.
175.
Laulederkind S (Poster), Shimoyama M, Patzer A, Petri V, Smith J, Nigam R, Kowalski G, Jin
W, Li D, Zuniga-Meyer A, Twigger S, Kwitek A, Jacob HJ. Gene curation efficiency improvements at the Rat Genome Database. Second International Biocurator Meeting. San
Jose, CA. October 2007.
176.
Adamovic T, McAllister D, Rowe J, Wang Tap, Jacob HJ and Sugg SL. Genetic Mapping of
QTLs controlling chemically induced mammary tumor latency and multiplicity on chromosome
10 using a novel SS/BN consomic rat model. Advances in Breast Cancer Research. San
Diego, CA. October 2007.
177.
Adamovic T, McAllister D, Rowe J, Wang T, Jacob HJ and Sugg SL. Identification of QTLs controlling mammary tumor latency and multiplicity on chromosome 10 in a novel SS/BN consomic rat model. Advances in Breast Cancer Research. San Diego, CA. October 2007.
178.
Nye SH, Harrington Y, Evans DL, Lu S, Marroquin LD, Jacob HJ, Will Y, Roman R. Tacrine toxicity detected in a rat test population. Cold Spring Harbor Laboratory, Rat Genomics &
Models. Cold Spring Harbor, NY. December 2007.
58

179.
Moreno C, Duran M, de Resende MM, Kaldunski ML, Lazar J, Lombard J, Greene AS, Cowley
Jr AW and Jacob HJ. Pleiotropic effects of the rennin loci. Cold Spring Harbor Laboratory,
Rat Genomics & Models. Cold Spring Harbor, NY. December 2007.
180.
O’Meara C, Lazar J, Moreno C, Tschannen M, Provoost AP, Jacob HJ. Investigating a triple congenic rat model to determine genes contributing to renal failure. Cold Spring Harbor
Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007.
181.
Rangel Filho A, Lazar J, Michalkiewicz M, Jacob HJ. Applications of viral vectors in rat genomics. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY.
December 2007.
182.
Rangel Filho A (Poster), Lazar J, Michalkiewicz M, Jacob HJ. Applications of viral vectors in rat genomics. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor,
NY. December 2007.
183.
Schilling RR, Lazar J, Hessner M, Moreno-Quinn C, Dwinell M, Lemke A, Wendt-Andrae J,
Jacob HJ. High-throughput production of rat knockout models for hypertension using ENU mutagenesis and a tilling assay. Cold Spring Harbor Laboratory, Rat Genomics & Models.
Cold Spring Harbor, NY. December 2007.
184.
Dwinell M, Shimoyama M, Kwitek AE, Greene AS, Cowley, Jr AW., Jacob HJ. Integrating
Physgen Program for Genomic Applications with RGD through ontologies. Cold Spring Harbor
Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007.
185.
Laulederkind S, Shimoyama M, Patzer A, Petri V, Smith J, Nigam R, Kowalski G, Jin W, De
Pons J, Zuniga-Meyer A, Twigger S, Dwinell M, Jacob HJ. Gene curation at the Rat Genome
Database. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY.
December 2007.
186.
Nigam R, Shimoyama M, Kowalski G, Laulederkind S, Smith J, De Pons J, Petri V, Patzer A,
Twigger S, Dwinell M, Jacob HJ. Worldwide repository for rat strains at the Rat Genome
Database. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY.
December 2007.
187.
Nigam R, Shimoyama M, Kowalski G, Laulederkind S, Smith J, De Pons J, Petri V, Patzer A,
Twigger S, Dwinell M, Jacob HJ. QTL at RGD: Linking phenotype to the genome. Cold
Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December
2007.
188.
Petri V, Shimoyama M, Patzer A, Kowalski G, Jennifer Smith, Stan Laulederkind, Jeff De Pons,
Melinda Dwinell, Simon Twigger, Jacob HJ. Pathway data at the Rat Genome Database.
Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December
2007.
189.
Shimoyama M, Petri V, Smith J, Laulederkind S, Nigam R, Kowalski G, De Pons J, Patzer A,
Twigger S, Dwinell M, Jacob HJ. The obesity/metabolic syndrome portal RGD. Cold Spring
Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007.
190.
Smith J, Shimoyama M, Petri V, Nigam R, Laulederkind S, Lowry T, Kowalski G, De Pons J,
Patzer A, Twigger S, Dwinell M, Jacob HJ. The Rat Genome Database: Biological information in a genomic context. Cold Spring Harbor Laboratory, Rat Genomics & Models.
Cold Spring Harbor, NY. December 2007.
191.
Twigger S, Kowalski G, Schlick N, Kwitek A, Hubner N and Jacob HJ. SNLPlotyper – a webbased SNP genotype/haplotype visualization & analysis tool. Cold Spring Harbor Laboratory,
Rat Genomics & Models. Cold Spring Harbor, NY. December 2007.
192.
Adamovic T, McAllister D, Rowe J, Wang T, Jacob HJ and Sugg SL. Genetic mapping of
QTLs controlling chemically induced mammary tumor latency and multiplicity on chromosome
10 using novel SS/BN consomic rat model. Cold Spring Harbor Laboratory, Rat Genomics &
Models. Cold Spring Harbor, NY. December 2007.
193.
Guryev V, Saar K, Adamovic T, Jacob HJ, Shull J, Hubner N & Cuppen E. Copy-number variation in genomes of laboratory rat strains: Distribution, properties and utility for human
59

genetics. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY.
December 2007.
194.
Gilbert S, Kwitek AE, Hubner N, Tschannen M, Jacob HJ, Bataillard A, Hessner M and
Sassard J. Integrated approaches to dissect complex disease. Cold Spring Harbor
Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007.
195.
Guryev V, Saar K, Adamovic T, Jacob HJ, Shull J, Hubner N and Cuppen E. Copy number variation in the rat. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring
Harbor, NY. December 2007.
196. Twigger S, Vallejos A, Halligan B, Shimoyama M, Petri V, Mirsa S, Pellitteri-Hahn M, Olivier M,
Jacob HJ and Greene A. APROPOS – I want it all, and I want it now. Cold Spring Harbor
Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007.
197. Geurts A, Matthewson E, Lu B, Bishop CE and Jacob HJ. Transposon knockouts by high throughput gene trapping in the rat. Cold Spring Harbor Laboratory, Rat Genomics & Models.
Cold Spring Harbor, NY. December 2007.
198. Jacob HJ. Translating Animal Models to the Clinic Setting. American Thoracic Society (ATS)
2008 International Conference. Toronto, Canada May 15 – 16, 2008.
199. Jacob HJ. The Complex Nature of QTLS: How Many Genes are Under the Peak? ARK-
Genomics Conference 2008 3 rd ISAFG. Edinburgh, Scotland April 7-9, 2008.
200. Petri V, Shimoyama M, Patzer A, dePons J, Dwinell M, Twigger S, Jacob HJ. Pathway Data at the Rat Genome Database. Cold Spring Harbor Biology of Genomes, May 2008.
201. Smith JR, Shimoyama M, Petri V, Laulederkind S, Nigam R, Lowry T, Stoddard A, dePons J,
Bakir B, Patzer A, Twigger S, Dwinell M, Jacob HJ. Annotated Datasets: Customizing your
Data at RGD. Cold Spring Harbor Biology of Genomes, May 2008.
202. Jacob HJ. From Whole Genome Associations. Hypertension 2008 June 14-19, 2008. Berlin,
Germany.
203. Lazar J, Wakatsuki T, Jacob HJ. Using Engineered Heart Tissue to Accelerate Positional
Cloning. Hypertension 2008 June 14-19, 2008. Berlin, Germany.
204. Geurts A, Lemke A, Moreno C, Dwinell M and Jacob HJ. PhysGen meets Sleeping Beauty – a match made in rat heaven. International Society of Hypertension. Berlin, June 2008.
205. Jacob HJ. Understanding Common Diseases Through Molecular Genetics: An Example Using
Kidney Failure. 13 th Intl SHR Symposium, June 20-22, 2008. Prague Czech Republic.
206. Dwinell MR, Shimoyama M, Nigam R, DePons J, Jacob HJ. Phenotypes and Models Portal at the Rat Genome Database. Intelligent Systems for Molecular Biology Meeting, Toronto,
Canada, July 19-24, 2008.
207. Shimoyama M, Dwinell M, Jacob HJ. Multiple ontologies for integrating complex phenotype datasets. Intelligent Systems in Molecular Biology Meeting, Toronto, CA, July 2008.
208. Roman RJ, Moreno C, Lazar C, Cowley Jr AW. and Jacob HJ. Narrowing of a region on rat chromosome 13 that protects against the development of hypertension using overlapping
Dahl SS.13BN congenic strains. Council of High Blood Pressure, Atlanta, September 2008.
209. Moreno C, Sweeney WE, Lazar J, Jacob HJ and Avner ED. Development of a rat model of
ARPKD to study genetic modifier loci. American Society of Nephrology.
Philadelphia,November 2008.
210. Jacob HJ, Provoost AP, Broeckel U, Lazarova Z, Lazar J and many former members of the
Jacob Lab. Identification of
. Rat Genomics & Models meeting, Cold Spring Harbor NY
2008 Dec 3-6.
211. Moreno-Quinn C, O’Meara C, Sweeney WE, Lazar J, Avner ED, Jacob HJ. Towards mapping modifier loci for ARPKD. Rat Genomics & Models meeting, Cold Spring Harbor
Laboratory/Wellcome Trust Conference Dec 3-6.
212. O’Meara C, Lazar J, Moreno-Quinn C, Provoost A, Jacob HJ. The contribution of the RF-3 QTL in the development of renal failure. Rat Genomics & Models meeting, Cold Spring Harbor NY
2008 Dec 3-6.
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213. Shimoyama M, Nigam R, Smkith J, Stoddard A, Munzenmaier D, Twigger S, Dwinell M, Jacob
HJ. Phenotypes at RGD: new tools for integrating and mining complex phenotype data. Rat
Genomics & Models meeting, Cold Spring Harbor NY 2008 Dec 3-6.
214. Smith J, Shimoyama M, Worthey L, Stoddard A, DePons J, Bakir B, Petri V, Laulederkind S,
Nigam R, Lowry T, Munzenmaier D, Patzer A, Twigger S, Dwinell M, Jacob HJ. Enhanced navigation of RGD data and tools. Rat Genomics & Models meeting, Cold Spring Harbor NY
2008 Dec 3-6.
215. Twigger S, DePons J, Smith J, Abraham D, Shimoyama M, Dwinell M, Munzenmaier D, Jacob
HJ and the Rat Genome Database Team. RGD education and outreach in the YouTube era. Rat
Genomics & Models meeting, Cold Spring Harbor NY 2008 Dec 3-6.
216. Shimoyama M, Petri V, DePons J, Twigger S, Dwinell M, Jacob HJ. Exploring pathway data through interactive diagrams and ontology at RGD. Rat Genomics & Models meeting, Cold
Spring Harbor NY 2008 Dec 3-6.
217. Dwinell M, Shimoyama M, Nigam R, DePons J, Munzenmaier D, Twigger S, Jacob HJ.
Phenotypes and models portal at RGD: providing an entree to genomics for physiologists. Rat
Genomics & Models meeting, Cold Spring Harbor NY 2008 Dec 3-6.
218. Worthey E, Bakir-Gungor B, DePons J, Twigger S, Dwinell M, Shimoyama M, Jacob HJ.
Exploring, examining and evaluating variation in the rat using the rat genome database. Rat
Genomics & Models meeting, Cold Spring Harbor NY 2008 Dec 3-6.
219. Schwartz D, Zhou S, Goldstein S, Potamousis K, Forrest D, Churas C, Jacob HJ, Guryev V,
Cuppen E. Discovery of structural variation in the rat genome via optical mapping. Rat
Genomics & Models meeting, Cold Spring Harbor NY 2008 Dec 3-6.
220. Guerts A, Choi V, DeKelver RC, Miller JC, Zeitler B, Wood A, Rebar EJ, Schilling R, Kalloway R,
Davis G, Urnov FD, Gregory PD, Sullivan P, Jacob HJ. Targeted medication of the rat genome using zinc finger nucleases. Rat Genomics & Models meeting, Cold Spring Harbor NY 2008 Dec
3-6.
221. Jacob HJ. Animal Cellular & Tissue Models. 1 st Annual Meeting of NGFN-Plus and NGFN
Transfer, Munich Germany. December 11 & 12, 2008.
222. Gros M, Lazar J, Moreno C, Jacob HJ and Lombard JH. Role of mitochondrial genome in modulating hypoxic dilation in cerebral arteries of animal models with type 2 diabetes mellitus. Rat Genomics and Models. Hinxton, UK. December 2008.
223. O’Meara C, Lazar J, Moreno C, Provoost AP and Jacob HJ. The contribution of the Rf-3
QTL in the development of renal failure. Rat Genomics and Models. Hixton, UK. December
2008.
224. Shimoyama M, Laulederkind S, Lowry T, Petri V, Smith J, dePons J, Stoddard A, Twigger S,
Dwinell M, Jacob HJ. Increasing Curation Efficiency: RGD’s Software Suite. Genome
Informatics, Qld Australia, December 2008.
225. O’Meara C, Lazar J, Moreno C, Provoost AP and Jacob HJ. The Contribution of Genes on
Chromosome 3 to Renal Failure in the Fawn Hooded Hypertensive Rat. Experimental
Biology, New Orleans, April 2009.
226. Moreno C, Rogge R, Tschannen M, Barreto N, Lazar J, Jacob HJ. Multiple Blood Pressure loci on rat Chromosome 18 attenuate the development of hypertension in the Dahl S
Hypertensive rat. Experimental Biology, New Orleans, April 2009.
227. Lu L, Li P, Yang C, Kurth T, Misale M, Skelton M, Moreno C,Greene AS, Jacob HJ, Roman RJ,
Lazar J, Liang M, Cowley, Jr AW. Dynamic utilization of biological pathways in protection against salt-sensitive hypertension. Council of High Blood Pressure, Chicago, September
2009.
228. Moreno C, Geurts A, Foeckler J, Kalloway S, Schilling R, Klotz R, Greene AS, Weiler H, Jacob
HJ. Development of a Rat Knockout for the Renin Gene. Council of High Blood Pressure,
Chicago, September 2009.
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229. Jacob HJ ‘The Rat Genome Contribution to understanding the Pathogenesis of
Hypertension’. Experimental Biology 2009 New Orleans.
230. Worthey L, DePons J, Shimoyama M, Smith J, Nigam R, Petri V, Laulederkind S, Lowry T,
Munzenmaier, D, Dwinell M, Twigger S, Jacob HJ. The Rat Genome Database Genome
Viewer. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5.
231. O’Meara C, Lazar J, Moreno C and Jacob HJ. Physiological genomics of the renal failure 3
(Rf-3) quantitative trait locus. Rat Genomics and Models. Cold Spring Harbor, NY. December
2009.
232. Strohl KP, Moreno C, Lazar J, Dostal J, Tschannen M, Erokwu B, Jacob HJ. Linkage to posthypoxic ventilatory behavior in the rat. Rat Genomics and Models. Cold Spring Harbor, NY.
December 2009.
233. Dwinell M, Shimoyama M, Nigam R, DePons J, Munzenmaier D, Twigger S, Jacob HJ, and the RGD team. Rat models for complex disease: using phenotypes to identify disease models.
Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5.
234. Hayman T, Shimoyama M, Laulederkind S, Lowry T, Nigam R, Petri V, Smith J, DePons J,
Stoddard A, Twigger S, Dwinell M, Munzenmaier D, Jacob HJ and the RGD Team. The diabetes disease portal at the rat genome database. Rat Genomics & Models meeting, Cold
Spring Harbor NY 2009 Dec 2-5.
235. Laulederkind S, Shimoyama M, Patzer A, Petri V, Smith J, Nigam R, Lowry T, Hayman T,
DePons J, Stoddard A, Bakir B, Twigger S, Dwinell M, Munzenmaier D, Jacob HJ. Multiple ontologies for prioritizing and standardizing biological information at the rat genome database. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5.
236. Lazar J, Rai D, Moreno-Quinn C, Sweeney W, Jacob HJ. Differential effect of a western diet on GK and T2DN rats. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5.
237. Lowry TF, Nigam R, Dwinell M, Munzenmaier D, Twigger S, Jacob HJ. Human quantitative trait loci (QTL) data within the rat genome database (RGD). Rat Genomics & Models meeting,
Cold Spring Harbor NY 2009 Dec 2-5.
238. Munzenmaier D, Dwinell M, Petri V, Shimoyama M, Jacob HJ. Physiological pathway diagrams at RGD: a new, interactive, online tool providing efficient access to genotype and phenotype data through biological pathway analysis. Rat Genomics & Models meeting, Cold
Spring Harbor NY 2009 Dec 2-5.
239. Nigam R, Shimoyama M, Twigger S, Munzenmaier D, Dwinell M, Jacob HJ and the RGD team. RGD: a repository and cumulative resource for rat strains. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5.
240. Nigam R, Shimoyama M, Twigger S, Munzenmaier D, Dwinell M, Jacob HJ and the RGD team. RGD a unique resource for rat QTL data: linking phenotype to the genome. Rat
Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5.
241. Petri V, Shimoyama M, DePons J, Stoddard A, Dwinell M, Munzenmairer D, Twigger S Jacob
HJ. Pathway resources at the rat genome database: a dynamic platform for integrating gene, pathway and disease information. Rat Genomics & Models meeting, Cold Spring Harbor NY
2009 Dec 2-5.
242. Rao V, Lazar J, Sarkis A, Wakatsuki T, Lam V, Jacob HJ. Engineered heart tissues help to identify potential sensitivity of a rat model to myocardial ischemia. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5.
243. Saar K, Hummel O, Patone G, Chen W, Jacob HJ, Hubner N. Genomic sequencing of three inbred rat strains. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5.
244. Sarkis A, Rao V, Wakatsuki T, Lazar J, Jacob HJ. Decellularized heart matrix as a scaffold for development of engineered heart tissue. Rat Genomics & Models meeting, Cold Spring
Harbor NY 2009 Dec 2-5.
62

245. Schilling RR, Geurts AM, Weiler H, Kalloway S, Foeckler J, Klotz J, Lemke A, Wendt-Andrae J,
Jacob HJ. Progress on zinc-finger nuclease-mediated gene distribution in the rat. Rat
Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5.
246. Shimoyama M, Stoddard A, Twigger S, Dwinell M, Munzenmaier D, Jacob HJ and the RGD team. RGD’s phenotype database and data mining tool.
247. Smith JR, DePons J, Shimoyama M, Worthey EA, Dwinell M, Twigger S, Jacob HJ and the
RGD team. At the rat genome database education is a two way street. Rat Genomics &
Models meeting, Cold Spring Harbor NY 2009 Dec 2-5.
248. Yang S, Schilling R, Foeckler J, Kalloway S, Geurts AM Jacob HJ.
transposon-based reprogramming of rat embryonic fibroblasts into pluropotency without inhibitors for FHH and
SD strains.
249. Geurts AM, Schilling R, Lemke A, Kalloway S, Foeckler J, Klotz J, Weiler H, Worthey L,
Ostertag E, Dwinell M, Mattson D, Lombard J, Cowley A, Moreno-Quinn C, Jacob HJ for the rest of GO team. The rat knockout project: unraveling complex human disease through advances in rat knockout technology. Rat Genomics & Models meeting, Cold Spring Harbor
NY 2009 Dec 2-5.
250. Kok-Reagles SM, Geurts AM, Noto FK, Lohman S, Duncan SA, Jacob HJ. Induced pluripotent stem cells as a platform for manipulation of the rat genome via conditional gene-trap mutagenesis. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5.
251. Jacob HJ, Rangel-Filho A, Schilling R, Lemke A, Kalloway S, Foeckler J, Klotz J, Weiler H,
Lazar J, Moreno-Quinn C, Geurts AM. Validation of RAB38 using transgenic rescue and gene
KO. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5.
252. Moreno-Quinn C, Hofman M, Lazar J, Lombard JH, Greene AS, Jacob HJ. Narrowing the blood pressure loci around the renin gene.
253. O’Meara C, Lazar J, Moreno-Quinn C, Jacob HJ. Physological genomics of the renal failure 3
-3) quantitative trait locus. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009
Dec 2-5.
254. Strohl KP, Moreno-Quinn C, Lazar J, Dostal J, Tschannen M, Erokwu B, Jacob HJ. Linkages to post hypoxic ventilatory behavior in the rat. Rat Genomics & Models meeting, Cold Spring
Harbor NY 2009 Dec 2-5.
255. Chen M, Rood W, Hecht A, Moreno C, Schilling C, McQuestion G, Jacob HJ. Animal Colony
Tracking System. Technology Fair 2010: Digital Path to Collaboration, MCW, Miwaukee,WI,
January 2010.
256. Feng D, Yang C, Kurth T, Liang M, Moreno C, Jacob HJ, Cowley AW. Renal Medullary
NAD(P)H-oxidase subunit p67ohox as a candidate gene in salt-sensitive hypertension.
Experimental Biology, Aneheim, April 2010.
257. Jacob HJ, Geurts AM, Schilling R, Lemke A, Kalloway S, Foeckler J, Klotz J, Weiler H,Lazar J,
Dwinell MR, Moreno C for GO grant team. From GWAS to function using sensitized strains, transgenic rescue and gene KO.The Biology of Genomes, May 11-15, 2010.
258. Tschannen M, Worthey E, Saar K, Tutaj M, Hummel O, Patone G, Chen W, Jacob HJ,
Hubner, N. Comparing genomic sequence of select large stretches of inbred rat strains using three different sequencing platforms in tandem. The Biology of Genomes, May 11-15, 2010.
259. Cowley AW Jr. Jacob HJ, Moreno C, Greene A, Lombard J, Mattson D, Lazar J, Dwinell MR,
Geurts AM. Unraveling the genomic basis of hypertension: rat model systems. International
Congress of Pathophysiology, Montreal, Canada, September 2010.
260. Geurts AM, Schilling R, Lemke A, Grzybowski M, Kalloway S, Foeckler J, Klotz J, Weiler H,
Lazar J, Dwinell MR, Moreno C, Jacob HJ. From genetics to function for human disease using transgenic rescue and gene KO in sensitized rat strains. International Congress of
Pathophysiology, Montreal, Canada, September 2010.
261. Jacob HJ, Geurts AM, Schilling R, Lemke A, Kalloway S, Foeckler J, Klotz J, Weiler H, Lazar J,
Dwinell MR, Moreno C, for the GO Grant Team. From GWAS to function using sensitized
63

strains, transgenic rescue and gene KO. American Heart Association HBPR 2010.
Washington, DC Oct 13-16, 2010.
262. Moreno C, Hoffman M, Didier D, Geurts M, Lazar J., Greene A, Jacob HJ. Initial
Characterization of the Renin Knockout Rat. American Heart Association HBPR 2010.
Washington, DC Oct 13-16, 2010.
263. Jacob HJ, Schilling RR, Lazar J, Moreno-Quinn, C. Using gene knock-outs and transposon based transgenics in sensitized rat strains to study genes nominated by human GWAS for renal disease. 43 rd Annual Meeting & Scientific Exposition, American Society of Nephrology
Nov. 16-21 2010.
264. Lazar J, Xu H, O’Meara C, Lazarova Z, Moreno C, Jacob HJ. A candidate gene for kidney failure. 43 rd Annual Meeting & Scientific Exposition, American Society of Nephrology Nov. 16-
21 2010.
265. Petri V, Shimoyama M, Hayman GT, Smith JR, dePons J, Dwinell MR, Munzenmaier DH,
Twigger SN, Jacob HJ. The Pathway Portal at the Rat Genome Database – an invitation to travel and explore.Systems Biology: Networks meeting, Cold Spring Harbor. March 2011.
266. Moreno C, Mattson DL, Geurts AM, Dwinell M, Lazar J, Schilling R, Hoffman M, Roman RJ,
Cowley AW Jr., Jacob HJ. Characterization of Nap5 KO rat for blood pressure and associated phenotypes. Experimental Biology, Washington, April 2011.
267. Hoffman M, Barreto N, Graff P, Lazar J, Jacob HJ, Moreno C. Narrowing of candidate region on rat chromosome 18 responsible for attenuating the development of hypertension in the
Dahl S hypertensive rat. Experimental Biology, Washington, April 2011.
268. Liu W, Munzenmaier D, Shimoayama, Dwinell M, Jacob HJ. A physiological pathway portal tool at the Rat Genome Database. Great Lakes Bioinformataics Conference, Athens Ohio.
May 2011.
269. O’Meara C, Sweeney WE, Hoffman M, Yeo NC, Tsaih SW, Lazar J, Jacob HJ, Avner ED,
Moreno C. Role of genetic modifiers in an orthologous model of ARPKD. FASEB PKD meeting,
Vermont, June 2011
270. Sarkis AB, Xiao B, Tsaih SW, Flister MJ, Lazar J, Lemke A, Zheng S, Hummel O, Saar K,
Hübner N, Worthey EA, Jacob HJ, Moreno Quinn CP. Whole-genome SNP Map Of The Dahl
Salt-sensitive And The Fawn-hooded Hypertensive Rats. American Heart Association’s High
Blood Pressure Research 2011 Scientific Sessions. Abstract #828, Orlando, Sept 21-24, 2011
271. Flister MJ, Geurts AM, Sarkis AB, O’Meara CC, Hoffmann B, Tsaih S, Lazar J, Moreno C,
Dwinell MR, Cowley AW, Lombard JH, Mattson DL, and Jacob HJ. Role of GWAS nominated gene SH2B3 in T-cell mediated renal damage and hypertension. High Blood Pressure
Research Scientific Sessions, Council for High Blood Pressure, Orlando FL, September 2011.
272. Sarkis AB, Xiao B, Tsaih S, Flister MJ, Lazar J, Hummel O, Saar K, Hübner N, Worthey EA,
Jacob HJ and Moreno C. Association Between mRNA Abundance and Genome-wide Single
Nucleotide Variant Analysis in Dahl Salt-Sensitive and Fawn-Hooded Hypertensive Rats. High
Blood Pressure Research Scientific Sessions, Council for High Blood Pressure, Orlando FL,
September 2011.
273. Liu P, Yang C, Tschannen M R, Lu Y, Jacob HJ, Liang M, Cowley A W. RNA-seq reveals
Numerous Novel Transcripts, Transcript Isoforms, and Sequence Variations in the Dahl Salt-
Sensitive Rat. HBPR2011, September 2011.
274. Zheng S, Flister MJ, Sarkis AB, Hoffman M, Moreno C, Lazar J, Jacob HJ. Genetic Dissection of Cardiovascular Disease with Rat Chromosome 12 Congenic Models. 21st Annual Medical
College of Wisconsin Research Day. October 2011.
275. Flister MJ, Zheng S, Sarkis AB, Hoffman M, Tsaih SW, Moreno-Quinn C, Lazar J, Jacob HJ.
Role of GWAS Nominated Gene SH2B3 in Cardiac Inflammation and Remodeling. 21st Annual
Medical College of Wisconsin Research Day. October 2011.
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276. Xiao B, Hoffman M, Tsaih SW, Sarkis A, Flister M, Zheng S, Lemke A, O’Meara C, Lazar J,
Jacob HJ, Moreno C. Identification of a Gender-Specific Gene for Salt-Sensitive
Hypertension. 21st Annual Medical College of Wisconsin Research Day. October 2011.
277. O’Meara CC, Yeo F, Flister MJ, Sarkis AB, Lazar J, and Jacob HJ. Assessing the Role of
GWAS Nominated
Gene as a Renal Function Candidate Gene. 2011 Graduate School
Research Poster Session, Medical College of Wisconsin, October 2011.
278. Tutaj M, Shimoyama M, Worthey E, Smith J, Jacob HJ. The Rat Genome Curation: RGD
Automated Data Integration Pipelines Maximize Coverage. Genome Informatics, Cold Spring
Harbor, November, 2011.
279. Liu W, Munzenmaier D, Shimoayama, Dwinell M, Jacob HJ. A physiological pathway portal tool at the Rat Genome Database. Genome Informatics, Cold Spring Harbor. November 2011
280. Sarkis AB, Tsaih SW, Flister MJ, Lazar J, and Jacob HJ. Using RNA-Seq data to identify genes contributing to ischemia response in rat cardiac fibroblasts. Gordon Research Conference
Newport RI July 2011
281. Laulederkind S, Tutaj M, Shimoyama M, Tayor B, De Pons J, Hayman T, Lowry T, Nigam R,
Petri V, Smith J, Wang S-J, Dwinell M, Munzenmaier D, Jacob HJ. The New Ontology
Browser at the Rat Genome Database. Cold Spring Harbor Rat Genomics and Models meeting, December 2011.
282. Zheng S, Flister MJ, Sarkis AB, Hoffman M, Moreno C, Lazar J, and Jacob HJ. Narrowing genetic regions on rat chromosome 12 involved in cardiovascular disease. Rat Genomics and
Models. Cold Spring Harbor, New York, December 2011.
283. Wang S-J , Laulederkind S, Shimoyama M, Petri V, Smith J, Nigam R, Lowry T, Hayman T, De
Pons J, Dwinell M, Munzenmaier D, Jacob HJ. Ontology Analyses of Genes in the RGD
Disease Portals. Cold Spring Harbor, New York, December 2011.
284. Endres B, Moreno C, Lombard J, Jacob HJ, Geurts A. Identifying Plekha7, an adherens junction protein, as a regulator of protein excretion in the kidney. Cold Spring Harbor, NY.
December 2011.
285. Tutaj M, Shimoyama M, Worthey E, Smith J, Jacob HJ. The Rat Genome Curation: RGD
Automated Data Integration Pipelines Maximize Coverage. Rocky 2011 Aspen December
2011
286. Liu W, Munzenmaier D, Shimoayama, Dwinell M, Jacob HJ. A physiological pathway portal tool at the Rat Genome Database. Rocky Mountains Bioinformatics December 2011, Aspen
CO.
287. Petri V, Smith J, Hayman T, de Pons J, Jayaraman P, Tutaj M, Shimoyama M, Dwinell M,
Munzenmaier D, Jacob HJ. The pathways suites at the Rat Genome Database: the networks controlling inflammatory responses – a case study. Rat Genomics & Models meeting, Cold
Spring Harbor, December 2011.
288. Flister MJ, Zheng S, Sarkis AB, Hoffman M, Lemke A, Schilling RR, Tsaih S, Dwinell MR,
Moreno-Quinn C, Lazar J, and Jacob HJ. Role of GWAS nominated gene SH2B3 in cardiac inflammation and remodeling. Rat Genomics and Models. Cold Spring Harbor, New York,
December 2011.
289. Xiao B, Hoffman M, Tsaih SW, Sarkis A, Flister M, Zheng S, Lemke A, O’Meara C, Lazar J,
Jacob HJ, Moreno C. Identification of a gender-specific gene for salt-sensitive hypertension.
Cold Spring Harbor, New York, December 2011.
290. Smith JR, Jayaraman P, Laulederkind S, Petri V, Nigam R, Lowry T, Hayman GT, Wang SJ,
DePons J, Dwinell MR, Munzenmaier D, Worthey EA, Shimoyama M, Jacob HJ. RGD's updated Genome Browsers: tools for data examination, exploration and discovery. Rat
Genomics and Models. Cold Spring Harbor, New York, December 2011
291. Schilling RR, Geurts AM, Dwinell MR, Moreno C, Kalloway S, Foeckler J, Richter S, Hansen C,
Casati M, Klotz J, Purman C, Wendt-Andrae J, Jacob HJ. Update: High Throughput Zinc-
65

Finger Nuclease-Mediated Gene Disruption in the Rat. Rat Genomics and Models. Cold Spring
Harbor, New York, December 2011.
292. Hayman T, Petri V, Shimoyama M, Jayaraman P, Tutaj M, De Pons J, Dwinell M, Munzenmaier
D, Jacob H. Expanded: an improved dynamic platform for integrating gene, pathway and disease data. . Rat Genomics and Models. Cold Spring Harbor, New York, December 2011
293. Liu W, Shimoyama M, Dwinell M, Jacob HJ. A PubMed Search Engine for Rat Genome
Curation at RGD. Conference on Semantics in Healthcare and Life Sciences. Cambridge MA.
February 2012.
294. Wang S-J, Laulederkind S, Shimoyama M, Hayman T, Lowry T, Nigam R, Petri V, Smith J,
De Pons J, Dwinell M, Munzenmaier D, Jacob H. Ontology Enrichment Analyses of Genes in the RGD Disease Portals. International Biocuration Meetings April 2012.
295. Moreno C, Hofman M, Flister MJ, Endres B, Greene AS, Lazar J, Jacob HJ , Xiao B. Narrow congenics reveal multiple gender-specific blood pressure loci around the renin gene.
Experimental Biology Annual Meeting 2012, San Diego, California, April 2012
296. Flister MJ, Jia S, Tsaih S, Sarkis A, Zheng S, Geurts A, Moreno-Quinn C, Lazar J, Hessner M,
Jacob HJ. GWAS nominated gene SH2B3 increases cardiac remodeling and inflammation associated with type 1 diabetes (T1D). Experimental Biology Annual Meeting 2012, San
Diego, California, April 2012.
297. Hayman GT, Jayarama P, Petri V, Shimoyama M, Tutaj M, De Pons J, Dwinell MR,
Munzenmaier D, Jacob HJ. The molecular pathway curation tool: the latest addition to the
Rat Genome Database curation tool suite, enabling efficient assembly, editing and display of interactive pathway diagram pages and associated biological data. Biocuration 2012,
Washington, DC Apr. 2012
298. Flister MJ, Jia S, Tsiah S, Sarkis A, Zheng S, Geurts A, Moreno-Quinn C, Lazar J, Jacob HJ,
Hessner M. The
Hessner M. The
diabetes. American Diabetes Association Scientific Sessions Annual Meeting 2012,
Philadelphia PA, June 2012.
299. Flister MJ, Jia S, Tsiah S, Sarkis A, Zheng S, Geurts A, Moreno-Quinn C, Lazar J, Jacob HJ,
Philadelphia PA, June 2012
[T] allele of SH2B3 elevates inflammatory response in Type 1
[T] allele of SH2B3 elevates inflammatory response in Type 1 diabetes. American Diabetes Association Scientific Sessions Annual Meeting 2012,
66