Alberta Co-Led Pre-Applications
Keywords
Lead
Genome
Centre
Genome
BC
Genome
BC
Genome
Prairie
Genome
Atlantic
Project
Leader
Co- Project
Leader
Catherine McManus
Gavin Oudit
Andrew Penn
Christoph Borchers
Shelagh Coutts
Darrell Mousseau
Glen Baker
Terry Lynn Young
Laura Gerull
Brenda Arbour
OGI
Stephen Barr
OGI
Stephen
Lye
Guido van Marle
Suzanne Tough
Lead
Organization
Title of Project
Research Areas
Methodologies and Technologies
Implementation and Evaluation
of Diagnostic Biomarkers for
University of
British Columbia Improved Management and
Treatment of Heart Failure
Chronic heart failure, diastolic heart Biomarkers, genomics, proteomics, bioinformatics,
diagnostics
failure, systolic heart failure,
biomarkers, health economics,
recovered heart function
Proteomic Markers for Rapid
Stroke Classification and
Vancouver Island
Intervention
Health Authority
Proteomics, TIA (Transient Ischemic
Attack) Biomarkers, Bioinformatics,
Epidemiology, Secondary Stroke
Prevention
MRM Mass spectrometry with SIS peptides, Crosssectional Validation Study, Clinical Utility Study,
Clinical-Biomarker Clinical Decision-Support App,
Usability Engineering
Do antidepressants influence
disease-modifying epigenetic
changes in Alzheimer's and
Parkinson's disease brains?
Epigenetic regulation, Alzheimer
disease, Parkinson disease, brain
region, antidepressant drugs,
relative risk, medical history
Epigenome-wide association scan (EW AS); autopsyconfirmed brain tissue; methylation analysis
(methylation 450K array); HisSeq2000 technology
(ChIP analysis); quantitative gene expression
analyses; biostatistics; retrospective chart reviews;
gas chromatography-mass spectrometric analysis of
antidepressant drugs and their major metabolites:
epidemiology; molecular genetics; transgenic
models
Genomics-Based Tools to
Prevent Sudden Death Due to
Cardiogenetic Conditions
Sudden Cardiac Death, Hereditary
lethal arrhythmias; highly penetrant
mutations, unique founder
populations
Whole genome sequencing technologies and
functional studies; unique founder populations;
transform the standards of clinical care
HIV/AIDS, drug-resistance, HIV
evolution, disease progression
Full-genome sequencing, single nucelotide
polymorphism haplotyples associations, drug
resistance testing/prediction, HIV quasispecies
evolution and fitness-testing, metabolomics
University of
Saskatchewan
Memorial
University
Identification of host and viral
predictors of HIV-1 evolution,
University of
drug resistance and disease
Western Ontario
progression
Mount Sinai
Hospital
Patient Stratification to Improves Preterm Birth, Stratified Medicine,
Outcomes in Preterm Birth
Biomarkers of Risk
Genetics, Genomics, Proteomics, Preclinical
Therapeutics, Implementation Science