“The Emerging Evidence
for Immune System
Control of Cancer:
Engineering the Cure”
Brendon Coventry
*Free coffee will be provided*
NOVEMBER 10, 2014
12PM-1PM
Abstract:
Immune system control of cancer has long been promised as a
viable therapeutic solution, but likewise has remained unproven and
enigmatic. Recent findings reinforce the tenet that the immune
system is already responding to the cancer within the patient.
Furthermore, it is capable of clinical effective cancer removal, but is
being down-regulated to prevent in-vivo intrinsic efficacy.
Problematically, using the immunotherapies noted above the
strength and direction of immune stimulation cannot yet be
determined, often resulting in serious auto-immunity, including
treatment-related deaths. Our work shows that serial monitoring of
inflammatory biomarkers in cancer patients reveals oscillatory
behavior, such that the timing of dose administration appears pivotal
for determining which way the immune response is being driven.
Improvement of clinical efficacy using these immunotherapeutic
approaches now brings the real prospect of cures from cancer firmly
into reach.
Brendon Coventry is a
surgeon at the University of
Adelaide’s School of
Medicine. His special
interests are Melanoma
Surgery, Breast Surgery,
Breast Reconstruction and
face and neck tumors.
Brendon has a PhD in Cancer
Immunology and research
interests in cancer vaccine
immunotherapies, and
sentinel lymph node
techniques. He is a Research
Director of the Australian
Melanoma Research
Foundation and has had
much success in treating
metastatic disease in
melanoma patients.
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