ABSTRACT BACKGROUND Good oral hygiene is essential for the well-being of an individual. However lack of knowledge, negative attitude and poor oral hygiene practices may lead to poor oral hygiene and predispose one to oral related diseases. This study sought to determine whether practice and knowledge on oral health relate to the oral hygiene status. OBJECTIVE The objective of the study was to assess the relationship between knowledge on oral hygiene awareness, practices and status among secondary school students. STUDY DESIGN This was a descriptive cross sectional study. STUDY AREA The study was carried out in three secondary schools inMaragua, Muran,gaCounty. STUDY POPULATION Thestudy involved both male and female students sampled from form one to form four in three secondary schools. METHODOLOGY Stratified sampling was used to select a sample of the students from the three schools. Qualitative data was collected using a mixed ended questionnaire and clinical data via oral examination of the students. Data was then be analyzed using SPSS version 13.0 and presented in form of tables charts and graphs. RESULTS: Majority of the students had average level of knowledge on oral health. Most of them brushed once a day. There was a relationship between the level of the knowledge of the students and the oral hygiene practices and their oral status. CONCLUSION: The level of knowledge on oral health affects oral hygiene practices and oral hygiene status. RECOMMENDATION: There is need to intensify oral health awareness in our secondary schools as this will have a positive impact on oral hygiene practices and oral hygiene status. 1