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CV of Assistant Professor Dr. Suthep Wiyakrutta
Name: Suthep Wiyakrutta
Education:
Ph.D., (Microbiology), Mahidol University, 1996
M.Sc. (Pharm Analysis), University of Strathclyde, U.K., 1986
B.Sc. in Pharm (Hons), Mahidol University, 1983
Research Interest:
Endophytic fungi; Microbial bioactive metabolites; Development of
enzymes for industrial applications
Award:
1. NRCT Excellent Thesis Award, 1999
Address:
Department of Microbiology, Faculty of Science, Mahidol University, Rama 6
road, Phayathai, Bangkok 10400, Thailand.
Tel.: +66-(0)2- 201-5671
E-mail: suthep.wiy@mahidol.ac.th
Publications:
1. Phaopongthai J, Wiyakrutta S, Meksuriyen D, Sriubolmas N, Suwanborirux K.* Azolesynergistic anti-candidal activity of Altenusin, a biphenyl metabolite of the endophytic
fungus Alternaria alternata isolated from Terminalia chebula Retz. J Microbiol 51(6):
821-828.
2. Boonman N, Prachya S, Boonmee A, Kittakoop P, Wiyakrutta S, Sriubolmas N, Warit S,
Dharmkrong-At Chusattayanond A*. In vitro acanthamoebicidal activity of fusaric acid
and dehydrofusaric acid from an endophytic fungus Fusarium sp. Tlau3. Planta Med 2012
Sep;78(14):1562-7.
3. Senadeera SP, Wiyakrutta S, Mahidol C, Ruchirawat S, Kittakoop P*. A novel tricyclic
polyketide and its biosynthetic precursor azaphilone derivatives from the endophytic
fungus Dothideomycete sp. Org Biomol Chem 2012 Sep 21;10(35):7220-6.
4. Chantarasiri A, Meevootisom V, Isarangkul Na Ayudthya D, Wiyakrutta S*. Effective
improvement of D-phenylglycine aminotransferase solubility by protein crystal-contact
engineering. J Mol Microbiol Biotechnol. 2012 Jul 24;22(3):147-155.
5. Jariyachawalid K, Laowanapiban P, Meevootisom V, Wiyakrutta S*. Effective
enhancement of Pseudomonas stutzeri D-phenylglycine aminotransferase functional
expression in Pichia pastoris by co-expressing Escherichia coli GroEL-GroES. Microb
Cell Fact. 2012 Apr 19;11(1):47.
6. Sureram S, Wiyakrutta S, Ngamrojanavanich N, Mahidol C, Ruchirawat S, Kittakoop P.
Depsidones, aromatase inhibitors and radical scavenging agents from the marine-derived
fungus Aspergillus unguis CRI282-03. Planta Med. 2012 Apr;78(6):582-8.
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7. Thammajaruk N, Sriubolmas N, Israngkul D, Meevootisom V, Wiyakrutta S* .
Optimization of culture conditions for mycoepoxydiene production by Phomopsis sp.
Hant25. J Ind Microbiol Biotechnol 2011 Jun;38(6):679-85.
8. Antia BS, Aree T, Kasettrathat C, Wiyakrutta S , Ekpa OD, Ekpe UJ, Mahidol C,
Ruchirawat S, Kittakoop P. Itaconic acid derivatives and diketopiperazine from the
marine-derived fungus Aspergillus aculeatus CRI322-03. Phytochemistry 2011
Jun;72(8):816-20.
9. Pandee P, Summpunn P, Wiyakrutta S , Isarangkul D, Meevootisom V*. A
Thermostable phytase from Neosartorya spinosa BCC 41923 and its expression in Pichia
pastoris . J Microbiol 2011 Apr;49(2):257-64.
10. Supa-Amornkul S, Wiyakrutta S , Poonswad P*. Wood decay fungi in hornbill nest
cavity in Khao Yai National Park, Thailand. Raff Bull Zool 2011 Mar;Suppl.24:95-113.
11. Jomrit J, Summpunn P, Meevootisom V, Wiyakrutta S* . Sensitive non-radioactive
determination of aminotransferase stereospecificity for C-4' hydrogen transfer on the
coenzyme. Biochem Biophys Res Commun 2011 Feb 25;405(4):626-31.
12. Summpunn P, Chaijan S, Isarangkul D, Wiyakrutta S , Meevootisom V*.
Characterization, gene cloning, and heterologous expression of ?-mannanase from a
thermophilic Bacillus subtilis . J Microbiol 2011 Feb;49(1):86-93.
13. Aromdee C, Sriubolmas N, Wiyakrutta S , Suebsasna S, Khunkitti W. Effect of the
derivatives of andrographolide on the morphology of Bacillus subtilis . Arch Pharm Res.
2011 Jan; 34(1):71-7.
14. Tianpanich K, Prachya S, Wiyakrutta S , Mahidol C, Ruchirawat S, Kittakoop P*.
Radical scavenging and antioxidant activities of isocoumarins and a phthalide from the
endophytic fungus Colletotrichum sp. J Nat Prod 2011 Jan;74(1):79-81.
15. Chomcheon P, Wiyakrutta S , Aree T, Sriubolmas N, Ngamrojanavanich N, Mahidol C,
Ruchirawat S, Kittakoop P. Curvularides A-E: antifungal hybrid peptide - polyketides
from the endophytic fungus Curvularia geniculata . Chemistry. 2010 Sep
24;16(36):11178-85.
16. Rojanarata T*, Opanasopit P, Ngawhirunpat T, Saehuan C, Wiyakrutta S , Meevootisom
V . A simple, sensitive and green bienzymatic UV-spectrophotometric assay of
amoxicillin formulations. Enzyme Microbial Technol 2010 Mar;46(3-4):292-296.
17. Ingavat N, Dobereiner J, Wiyakrutta S, Mahidol C, Ruchirawat S, Kittakoop P.
Aspergillusol A, an alpha-Glucosidase Inhibitor from the Marine-Derived Fungus
Aspergillus aculeatus. J. Nat. Prod. 2009, 72, 2049–2052.
18. Laiwattanapaisal W*, Yakovleva J, Bengtsson M, Laurell T, Wiyakrutta
S, Meevootisom V, Chailapakul O, Emn?us J. On-chip microfluidic systems for
determination of L-glutamate based on enzymatic recycling of substrate.
Biomicrofluidics 2009 Jan-Mar;3(1):014104.
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19. Chomcheon P, Wiyakrutta S, Sriubolmas N, Ngamrojanavanich N, Kengtong S,
Mahidol C, Ruchirawat S, Kittakoop P. Aromatase inhibitory, radical scavenging, and
antioxidant activities of depsidones and diaryl ethers from the endophytic fungus
Corynespora cassiicola L36. Phytochemistry. 2009 Feb;70:407-413.
20. Chomcheon P, Wiyakrutta S, Sriubolmas N, Ngamrojanavanich N, Mahidol C,
Ruchirawat S, Kittakoop P. Metabolites from the endophytic mitosporic Dothideomycete
sp. LRUB20. Phytochemistry. 2009 Jan;70 (121-127)
21. Sappapan R, Sommit D, Ngamrojanavanich N, Pengpreecha S, Wiyakrutta S,
Sriubolmas N, et al. 11-Hydroxymonocerin from the plant endophytic fungus
Exserohilum rostratum. J Nat Prod. 2008 Sep;71(9):1657-9.
22. Kasettrathat C, Ngamrojanavanich N, Wiyakrutta S, Mahidol C, Ruchirawat S,
Kittakoop P. Cytotoxic and antiplasmodial substances from marine-derived fungi,
Nodulisporium sp. and CRI247-01. Phytochemistry. 2008 October;69(14):2621-6.
23. Boonman N, Wiyakrutta S, Sriubolmas N, Dharmkrong-at Chusattayanond A.
Acanthamoebicidal activity of Fusarium sp. Tlau3, an endophytic fungus from
Thunbergia laurifolia Lindl. Parasitology research. 2008 Oct;103(5):1083-90.
24. Chinworrungsee M, Wiyakrutta S, Sriubolmas N, Chuailua P, Suksamrarn A. Cytotoxic
activities of trichothecenes isolated from an endophytic fungus belonging to order
hypocreales. Archives of pharmacal research. 2008 May;31(5):611-6.
25. Prachyawarakorn V, Mahidol C, Sureram S, Sangpetsiripan S, Wiyakrutta S, Ruchirawat
S, et al. Diketopiperazines and phthalides from a marine derived fungus of the order
pleosporales. Planta Med. 2008 Jan;74(1):69-72.
26. Saehuan C, Rojanarata T, Wiyakrutta S, McLeish MJ, Meevootisom V. Isolation and
characterization of a benzoylformate decarboxylase and a NAD+/NADP+-dependent
benzaldehyde dehydrogenase involved in D-phenylglycine metabolism in Pseudomonas
stutzeri ST-201. Biochim Biophys Acta. 2007 Nov;1770(11):1585-92.
27. Prachya S, Wiyakrutta S, Sriubolmas N, Ngamrojanavanich N, Mahidol C, Ruchirawat
S, et al. Cytotoxic mycoepoxydiene derivatives from an endophytic fungus Phomopsis sp.
isolated from Hydnocarpus anthelminthicus. Planta Med. 2007 Oct;73(13):1418-20.
28. Chomcheon P, Sriubolmas N, Wiyakrutta S, Ngamrojanavanich N, Chaichit N, Mahidol
C, et al. Cyclopentenones, scaffolds for organic syntheses produced by the endophytic
fungus mitosporic dothideomycete sp. LRUB20. J Nat Prod. 2006 Sep;69(9):1351-3.
29. Chomcheon P, Wiyakrutta S, Sriubolmas N, Ngamrojanavanich N, Isarangkul D,
Kittakoop P*. 3-Nitropropionic acid (3-NPA), a potent antimycobacterial agent from
endophytic fungi: Is 3-NPA in some plants produced by endophytes? J Nat Prod July
2005;68(7):1103-5.
30. Wiyakrutta S, Sriubolmas N*, Panphut W, Thonggon N, Danwiset-kanjana,
Ruangrungsi N, Meevootisom V. Endophytic fungi with anti-microbial, anti-cancer and
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anti-malarial activities isolated from Thai medicinal plants. World J Micro Biot
Jan 2004;20(3):265-72.
31. Wang X, Upatham S, Panbangred W, Isarangkul D, Summpunn P, Wiyakrutta
S, Meevootisom V*. Purification, characterization, gene cloning ans sequence analysis of
a phytase from Klebsiella pneumoniae subsp. pneumoniae XY-5. ScienceAsia
Dec 2004;30(4):383-390.
32. Rojanarata T, Isarangkul D, Wiyakrutta S, Meevootisom V, Woodley JM*. Controlledrelease biocatalysis for the synthesis of D-Phenylglycine. Biocatal Biotransfor
May 2004;22(3):195-201.
33. Khampha W, Yakovleva J, Isarangkul D, Wiyakrutta S, Meevootisom V, Emneus J*.
Specific detection of L-glutamate in food using flow-injection analysis and enzymatic
recycling of substrate. Anal Chim Acta Aug 2004; 518(1-2):127-135.
34. Khampha W, Meevootisom V, Wiyakrutta S*. Spectrophotometric enzymatic cycling
method using L-glutamate dehydrogenase and D-phenylglycine aminotransferase for
determination of L-glutamate in foods. Anal Chim Acta Aug 2004;520(1-2):133-139.
35. Kongsaeree P*, Samanchart C, Laowanapiban P, Wiyakrutta S, Meevootisom V.
Crystallization and preliminary X-ray crystallographic analysis of d-phenylglycine
aminotransferase from Pseudomonas stutzeri ST201. Acta Crystallogr D Biol Crystallogr
2003;59(Pt 5):953-4.
36. Kongsaeree P*, Prabpai S, Sriubolmas N, Vongvein C, Wiyakrutta S. Antimalarial
dihydroisocoumarins produced by Geotrichum sp., an endophytic fungus of
Crassocephalum crepidioides. J Nat Prod 2003;66(5):709-11.
37. Plainkum P, Fuchs SM, Wiyakrutta S, Raines RT*. Creation of a zymogen. Nat Struct
Biol 2003;10(2):115-9.