Study Towards Asymmetric Synthesis of 3-epi-Eupomatilone-6
Sariya Yodwaree1,*, Manat Pohmakotr1, Chutima Kuhakarn1, Patoomratana Tuchinda1,
Vichai Reutrakul1, Darunee Soorukram1,#
1
Organic Chemistry Program, Department of Chemistry, Faculty of Science, Mahidol
University, Rama VI Road, Bangkok 10400, Thailand
*e-mail: y.sariya@hotmail.com, #e-mail: darunee.soo@mahidol.ac.th
Abstract
Eupomatilones, such as eupomatilone-3 and eupomatilone-6, are structurally novel lignan
natural products. Their unusual biaryl skeleton was proposed to derive from an
unprecedented rearrangement. Asymmetric synthesis towards 3-epi-eupomatilone-6 was
investigated in this study.
Acknowledgements: Financial support from the Thailand Research Fund (to D.S.,
MRG5580046), the Office of the Higher Education Commission and Mahidol University
under the National Research Universities Initiative, Mahidol University, and the Center of
Excellence for Innovation in Chemistry (PERCH-CIC) are gratefully acknowledged.
Keywords: eupomatilone, lignan, conjugate addition
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