Introduction to Mass Spectrometry
One day short course
Based on its highly successful biennial two-day LC-MS short course, which has been
running since 1997, and its inaugural MS course at last year’s Cardiff meeting, the British
Mass Spectrometry Society is pleased to offer a one-day course: Introduction to Mass
Spectrometry, now twice at its 2011 annual meeting.
When
1st Opportunity:
Sunday, 11th September 2011
This course provides a perfect primer for the BMSS 2011 meeting:
From Atoms to Biomolecules - Celebrating the technological innovations in mass
spectrometry, 11th-14th September 2011
2nd Opportunity:
Tuesday, 13th September 2011
This course provides a second opportunity for professionals with a busy schedule to
attend. As it will be run in parallel to the BMSS 2011 meeting, there will be a reduction of
£50 of the course fees for delegates who paid the registration fees for the entire annual
meeting.
Where
Cardiff City Hall, Gorsedd Gardens Road, Cardiff CF10 3ND
Who should attend?
The course covers the fundamental aspects of mass spectrometry, assuming an
undergraduate level of basic chemistry, but requiring no previous knowledge of the
technique or practical experience.
This introductory course is designed for scientists from other disciplines (incl. the clinical,
pharmaceutical and life sciences, and novices to MS from archeology to zoology) or
laboratory managers who will be employing mass spectrometry data in their analytical
projects and wish to gain a solid understanding of the technique or who want to gain an
awareness of its potential applications. The course will be useful for post-graduate
research students embarking on research projects involving mass spectrometry. Current
users of mass spectrometry will also find “Introduction to Mass Spectrometry” an excellent
refresher to the theory of the technique and a means to keep abreast of recent
developments and advances in this rapidly changing field.
Course content
This course will introduce the basic concepts and terminology of mass spectrometry. The
course will cover the most important ionisation techniques used in mass spectrometry,
including: electron ionisation, matrix assisted laser desorption/ionization and atmospheric
pressure ionisation techniques and will provide details of the most common mass
analysers including: quadrupoles, ion traps, time-of-flight and hybrid instruments.
The following topics are also covered: atomic and molecular masses, mass resolution,
exact masses and isotopes, sample preparation, interfacing mass spectrometry with
chromatographic techniques, ion detection, processing of mass spectral data, elementary
spectral interpretation, and considerations for the mass spectrometry of large molecules.
Using relevant, real-world examples such as common drugs and clinically relevant
analytes, the course will illustrate both qualitative and quantitative applications of mass
spectrometry.
The course is designed to give delegates a solid foundation in mass spectrometry, to
appreciate the advantages and limitations of the technique and to assist scientists in
choosing the most appropriate instrumentation for a particular analytical challenge.
The course will provide a logical primer for subsequent more advanced training courses
that cover more specialized areas of mass spectrometry.
Course Material
Each delegate will receive a course manual containing complete lecture notes together
with other background information such as key references and a guide to mass
spectrometry resources. Copies of Best Practice Guides for Generating Mass Spectra and
Accurate Mass Measurement of Small Molecules are also provided.
Delegates will also receive a copy of Anthony Mallet and Steve Down’s recently published
“Dictionary of Mass Spectrometry”.
CPD
The Royal College of Pathologists and The Institute of Biomedical Science have both
approved the course for CPD credits ( 6 and 7 credits respectively) and other Professional
Bodies, such as the Royal Society of Chemistry, will accept the course as contributing to
an individual’s CPD Portfolio if it relevant to their employment
Course Tutors
The course tutors are all members of the BMSS, drawn from industry, instrument
manufacturers and academia, who are all experts in their particular fields of mass
spectrometry and have considerable experience in the theory and application of the
technique. The course provides access to this expertise and an opportunity for networking
within a rapidly growing user base.
Further information and short biographical sketches of the course tutors are available
below.
Registration and Payment
The cost of the course is £350 which includes lunch, refreshments and course manual.
The BMSS offers a discounted rate of £200 for full time and part time students undertaking
research in mass spectrometry when accompanied by confirmation of the academic
institution.
Registration is via the Cardiff 2011 Registration form available at
http://www.bmss.org.uk/cardiff/index.html - via the main registration form (Note:
registration for the meeting is not required for attendance on the course)
Accommodation
Accommodation in Cardiff can be booked via the BMSS website
http://www.bmss.org.uk/cardiff/index.html
Further Details
Anna Upton, BMSS Administrator
Tel: +44 (0)1582 793906
E: bmssadmin@btinternet.com
Introduction to Mass Spectrometry
1 day short course
September 2011
Course Agenda
08:30 - 09:00
Registration and Coffee
09:00 - 09:10
Welcome & Housekeeping
09:10 – 09:40
Lecture 1 – Basics of Mass Spectrometry
Dr Mark Harrison
09:40 - 10:30
Lecture 2 – Ionisation techniques
Prof Rainer Cramer
10:30 - 11:00
BREAK
11:00 - 11:40
Lecture 3 – Mass Analysers Part I: Quads and Traps
Dr Mark Harrison
11:40 - 12:20
Lecture 5 – Mass Analysers Part II: ToF’s and Hybrids
Dr Jackie Mosely
12:20 - 13:20
LUNCH
13:30 – 14:00
Lecture 5 – Sample Introduction: Interfacing MS with chromatography
Dr Steve Pleasance
14:00 - 14:40
Lecture 6 – Mass Resolution and Accurate Mass Measurements
Dr Jackie Mosely
14:40 - 15:00
BREAK
15:00 - 15:40
Lecture 7 – Qualitative Mass Spectrometry:
Dr Tony Bristow
15:40 – 16:20
Lecture 8 – Quantitative Mass Spectrometry
Dr Steve Pleasance
16:20 – 16:40
Course summary and close
Introduction to Mass Spectrometry
One day short course
September 2011
Course Tutors
Dr Mark Harrison is a senior scientist at
ThermoFisher Scientific. He has over 25 years
experience of LC/MS research. Mark started
his LC/MS life working at the University of
London running the intercollegiate research
service. The majority of his mass spec career
has been spent working for an instrument
manufacturer. He has extensive practical
experience of quadrupoles, ion traps and high
resolution instruments. Having spent most of
his working life supporting customer’s
research, he has experience with a wide
range of applications and trouble shooting. He
still maintains very much a hands-on approach
either in the Thermo demonstration laboratory
or on customer’s sites.
Prof Rainer Cramer FRSC is Head of Mass
Spectrometry and Proteomics and Professor
of Mass Spectrometry and Bioanalytical
Sciences at the University of Reading. He is
an interdisciplinary scientist, who started his
academic career as an experimental physicist
and later moved on to cancer research and
other research fields in the life sciences.
Rainer has a strong background in biological
mass spectrometry, proteomics and analytical
chemistry. In general, his research interests
are focused on the application of his physical
science expertise to the analytical challenges
posed by modern biosciences. He also has a
strong interest in the fundamentals of mass
spectrometry, particularly MALDI MS.
Dr Jackie Mosely began research into
fundamental aspects of mass spectrometry
during a PhD at the University of Warwick,
UK, before continuing at the University of
Waterloo, Canada. Employment followed as
an Application Scientist, later becoming the
Senior Scientist for Bruker Daltonics Ltd,
supporting all civilian MS-based product
lines. Returning to University, this time
Durham University, to run the Mass
Spectrometry Service and set-up an
independent research group has opened
many interesting areas of investigation
including ambient ionisation techniques and
developing tandem MS technology,
establishing numerous successful
collaborations in the process.
Dr Steve Pleasance, CChem FRSC, is
Managing Director of Quotient’s Bioanalytical
Sciences business unit. As a former Head of
World-wide Bioanalysis at GlaxoSmithKline
(and previously at GlaxoWellcome and
Wellcome), Steve has over 20 years
experience providing bioanalytical support
both within and for the pharmaceutical
industry. He gained his BSc in Chemistry at
Newcastle, a PhD in Mass Spectrometry from
Cardiff and conducted Post Doc research in
Canada. He is a Fellow of the Royal Society of
Chemistry and has been a tutor for the British
Mass Spectrometry Society's course on LCMS for over 10 years.
Dr Tony Bristow is Associate Principal
Scientist in mass spectrometry within
Pharmaceutical Development at AstraZeneca
in Macclesfield. He focuses on the application
and development of mass spectrometry at all
stages in the development of pharmaceuticals.
Tony carried out a PhD on MALDI ion trap
mass spectrometry under the supervision of
Prof Colin Creaser at Nottingham Trent
University. In 1995 Tony moved to Kodak
Limited in Harrow, where he worked in both
mass spectrometry and separation science.
Following a secondment from Kodak to LGC
in Teddington, Tony joined LGC in 2002,
working on a variety of mass spectrometrybased projects. Tony is a regular presenter at
both national and international conferences
and currently holds the post of BMSS ViceChair.