Supplementary table 1
Target
Surface molecules
ECM
Fibrin
Macrophages
Neovascularization
Proteolytic
enzymes
Apoptosis
Lipids
Medium (label)
Accumulation
Unspecific/specific
Gadofosveset trisodium
unspecific
Gd-labeled VCAM-I specific nanoparticles
Surface molecules, plaque
matrix
endothelial surface
T1/T2shortening
T1
specific
T1
mice, ex vivo
human [3; 4]
no
Elastin-specific Gd-labeled contrast agent (ESMA)
plaque matrix, elastic fibers
specific
T1
mice, swine [5-7]
no
Gadofluorine M
plaque matrix
unspecific
T1
rabbit [8-10]
no
Gd-labeled peptides (e.g. EP-2104R, EP-1242, EP1240)
plaque matrix
unspecific
T1
mice, rabbit,
human [11-15]
yes
Gd-labeled fibrin-avid nanoparticles
plaque matrix
specific
T1
mice [16]
no
Iron-oxide nanoparticles (SPIO, USPIO)
macrophage rich areas
unspecific
T2
mice, rabbit,
human [17-20]
yes
Gd-based immunomicelles and nanoparticles targeted
against the macrophage scavenger receptor
macrophage rich areas
unspecific
T2
mice, rabbit,
human [21]
no
Gd-loaded LDL-based nanoparticles and modified Gdlabeled HDL-nanoparticles
Gadofosveset trisodium
macrophage rich areas
unspecific
T1
mice [22; 23]
no
plaque neovascularization
unspecific
T1
mice, swine [1;
24; 25]
no
plaque neovascularization,
endothelial surface
plaque matrix of MMP-rich
plaques
plaque matrix
specific
T1
rabbit [26; 27]
no
unspecific
T1
no
unspecific
T1
mice, rabbit fil
[28; 29]
rabbit [8; 30]
plaque matrix
unspecific
T1
mice [31]
no
macrophages
unspecific
T1
mice [23; 32; 33]
no
Αvβ3 specific gadolinium-coated perfluorocarbon
nanoparticles
Gadolinium-labeled MMP-inhibitor (P947)
Paramagnetic electron donor compound conjugated to
Gd-DOTA (Gd-MPO)
Gd-labeled Annexin 5-functionalized nanoparticles
Gd-loaded LDL-based nanoparticles and modified HDLnanoparticles
Species
mice [1; 2]
FDA
approval
no
no
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