Appendix A. Drug Sample Type Interference Physiological

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Appendix A.
Drug
Sample Type
Interference
Physiological/Pharmological or Methodological (M) Effect
Acetaminophen
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Plasma
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Hemoglobin ↓
Methemoglobin ↑
Neutrophils ↓
Red Cell Count ↓
White Cell ↓
Prothrombin Time ↑
Bilirubin ↑
Creatinine ↑
Direct Bilirubin ↑
Glucose ↓
Iceteric Index ↑
SGOT ↑
SGPT ↑
Urea Nitrogen ↑
Uric Acid ↑
Protein ↑
Sulfate ↓
Uric Acid ↑
UA Bile ↑
UA Casts ↑
UA Cells ↑
UA Methemoglobin ↑
UA Protein ↑
UA RBC/ HPF ↑
Volume ↓
Bleeding Time ↑
Eosinophils ↑
Erythrocyte Survival ↓
Factor VII ↓
Heinz-Body Formation +
Hematocrit ↓
Hemoglobin ↓
Methemoglobin ↑
PCO2 ↓
pH ↓
pH ↑
Anemia/ Pancytopenia
May Rarely Cause Hemolysis
May Cause Neutropenia/Pancytopenia
May Cause Hemolytic Anemia
May Affect Bone Marrow Function/ Pancytopenia
Depresses Clotting Factor Synthesis
Hepatic Damage Reported With Overdose
Reversible Tubular Necrosis Reported
Hepatic Necrosis With Dose of 10g Reported
Reported Effect of Metabolite
May Cause Hepatic Toxicity
Hepatic Necrosis With Dose of 10g Reported
Hepatic Necrosis With Dose of 10g Reported
Reversible Tubular Necrosis Reported
Falsely High Values With Phosphotungstate Methods (M)
Renal Damage May Occur
Reduces ↑d Output of Rheumatoids
Falsely High Values With Phosphotungstate Methods (M)
Hepatic Necrosis May Occur With Dose of 10g
Renal Damage Due to Hemolysis/Anuria
May be Marked ↑ in Renal Tubular Cells
Renal Damage Due to Hemolysis
Nephrotoxic Effect of Drug
Renal Damage Due to Hemolysis
↑ Transport of Water in Diabetes Insipidus
Also Inhibits Platelet Glycolysis
May Cause Aplastic Anemia or Pancytopenia
Large Doses ↑ Destruction
Acts Like Bishydroxycoumarin
Occur Initially but Disappear with Hemolysis
Depresses Bone Marrow, G.I. Bleeding, Hemolytic Anemia
Depresses Bone Marrow, G.I. Bleeding, Hemolytic Anemia
May Cause Hemolysis with G6PD
In Toxicity with ↑ Respiratory Rate and Pulm Vent
May Cause Acidosis Later (Respiratory and Metabolic)
Initial Respiratory Alkalosis
Acetylsalicylic Acid
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Cerebrospinal Fluid
Erythrocyte
Fecal
Fecal
Other Bodily Fluid
Plasma
Plasma
Plasma
Plasma
Plasma
Plasma
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Platelet Aggregation ↓
Platelet Count ↓
Red Cell Count ↓
Reticulocytes ↑
Sedimentation Rate ↓
Sedimentation Rate ↑
White Cell Count ↓
Protein ↑
Reduced Glutathione ↓
Color ↑
Occult Blood +
Basal Metabolic Rate
Fibrinogen ↑
Hemoglobin ↑
Prothrombin Time ↓
Prothrombin Time ↑
Thyroid Stimulating Hormone↓
17 Hydroxy Corticosteroids ↑
Acetoacetate ↑
Albumin ↓
Aldolase ↑
Alkaline Phosphatase ↑
Amylase ↑
Barbiturate ↑
Bilirubin ↑
Calcium Bilirubin ↓
Cholesterol ↓
Cholesterol ↑
CO2 Content ↓
CO2 Content ↑
Direct Bilirubin ↑
Free Thyroxine ↑
Serum
Serum
Serum
Free Triiodothyronine ↑
Glucose ↓
Glucose ↑
Serum
Serum
Serum
Iodine 131 Uptake ↓
Iron ↓
Ketones ↓
Inhibits Release of ADP From Platelets
↓ Platelet Survival Time, May be Purpura
Hemolysis/ G6PD/ G.I. Hemorrhage/ Direct Bone Marrow Depression
Response During Recovery From Hemolysis
If Elevated Reduces Toward Normal Value
Occurs in Some Patients (Reversible)
Depress Leukocytosis of Acute Rheumatic Fever
False + with Folin-Ciocalteu Reagent (M)
Occurs Initially Before Overt Hemolysis
Red or Black Due to Gastrointestinal Bleeding
In Over 70% Patients When More Than 3g/Day Given
Reported Metabolic Effect
Associated with ↑ Sedimentation Rate
Occurs with Hemolytic Anemia
Small Dose Effect
Large Dose Effect (↓ Synthesis of Clot Factors)
Release After Administration
Large Dose Stimulate Adrenocortical Activity
Due to Late Metabolic Acidosis and Renal Impair
Decreased Dye Binding Capacity (M)
Experimental Effect Seen in Rabbits with Prolonged Use
Prolonged Use May Cause Hepatic Toxicity
Single Case Reported
May Interfere with UV Spectrophotometry (M)
Competition For Albumin Binding
Depresses Fluorescence of Calcein Method (M)
Doses Over 5g Reported to Have Effect
Alleged Effect (M)
Initial Acidosis with Excessive Doses
Later Alteration of Acid Base Balance
Occurs with Hemolytic Anemia
Interferes with Binding to Thyroxine Binding Globulin and
Thyroxine Binding Prealbumin
Interferes with Binding to Thyroxine Binding Globulin
In Diabetics and if Toxic Doses Ingested
↑ Absorption and Steroid Release Inhibits Trichloroacetic Acid
or Tricarboxylic Acid
With Large Doses and Chronic Administration
May Be Markedly Reduced with Large Doses
↑ Oxidation of Ketone Bodies in Diabetics
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Ketones ↑
Lactate ↑
Lactate Dehydrogenase ↑
Non Esterified Fatty Acids↓
Protein-Bound Iodine ↓
Due to Induced Acidosis
Due to Late Metabolic Acidosis and Renal Impair
Experimental Effect Seen in Rabbits with Prolonged Use
↑ Fatty Acid Oxidation, ↓ Lipogenesis
Competes For Thyroxine Binding Prealbumin Also
Uncouples Phosphorylation
Phospholipids ↓
↑ Fatty Acid Oxidation, ↓ Lipogenesis
Potassium ↓
Diuretic Action, Respiratory Alkalosis
Pyruvate ↑
Due to Late Metabolic Acidosis and Renal Impair
Salicylate ↑
Due to Ingestion of Compound
SGOT↑
Prolonged Admin, May Cause Hepatic Toxicity
SGPT ↑
Prolonged Use May Cause Hepatic Toxicity
Thyroxine (T4) ↓
Displaces Thyroxine From Binding Sites
Triiodothyronine Uptake ↑
Red Cell Uptake Affected Also Affects Resin Test
Urea Nitrogen ↑
May Have Nephrotoxic Effect
Uric Acid ↓
Mild Uricosuric Action (Large Dose Effect)
Uric Acid ↑
Acts as Reducing Substance with Non-Specific Methods (M)
Uric Acid ↑
Small Dose Effect
Uric Acid ↑
Low Doses Reduce Renal Excretion of Uric Acid
5-Nucleotidase ↑
Reversible Hepatotoxicity with Prolonged Admin
Acetoacetate ↑
Reacts with Gerhardt Ferric Chloride Procedure (M)
Acetoacetate ↑
Acidotic Response Especially in Children
Alkaline Phosphatase ↑
Due to Nephrotoxic Effect of Drug
Alpha Amino Nitrogen ↑
Inhibition of Reabsorption, ↑ Protein Catabolism
Amino Acids ↑
Two Fold ↑ After 1.6g in Normal
Ascorbic Acid ↑
Reported Effect
Bicarbonate ↑
Response to Respiratory Alkalosis of Early Toxicity
Catecholamines ↑
Interfering Fluorescence in Many Procedures (M)
Dihydroxyphenylalanine Screen + Light Amber Color Produced (M)
Fouchet Test +
Produces Purple Color (M)
Glomerular Filtration Rate ↓
Nephrotoxicity of Drug Occurring Acutely
Glucose ↓
Glucose Oxidase Methods Inhibited by Gentisic Acid (M)
Glucose ↑
Inhibits Liver and Muscle Glycogen Synthesis
Homogentisic Acid ↑
Interferes with Measurement Procedure (M)
Ketones ↓
↑ Oxidation of Ketone Bodies in Diabetics
Ketones ↑
Reddish Color with Gerhardt's Test (M)
Lactic Dehydrogenase ↑
Renal Irritation & Desquamation of Epithelial Cells
Leucine Aminopeptidase ↓
Due to Antifibrinolytic Action
Nitrogen ↑
Effect Observed in Adults
Phenylketones +
Purple with Ferric Chloride, Purple with Phenistix (M)
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Albumin
Cerebrospinal Fluid
Serum
Albumin, Human Serum Alkaline
Serum
Amphotericin B
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Fecal
Plasma
Serum
Serum
Serum
Phosphate ↑
Potassium ↑
Protein ↑
Protein ↑
Phenosulfonphalein Excretion ↓
Sodium ↑
Sugar ↑
Taurine ↓
Uric Acid ↓
Uric Acid ↑
Uric Acid ↑
UA Casts ↑
UA Cells ↑
UA Glucose ↓
UA Glucose ↑
UA Hemoglobin ↑
UA Ketones ↓
UA Ketones ↑
UA Protein ↑
UA RBC/ HPF ↑
UA Sugar ↑
UA WBC/ HPF ↑
Vanillylmandelic Acid ↑
Volume ↑
Xylose Excretion ↓
17 Hydroxy Corticosteroids ↓
Ascorbic Acid ↓
Protein ↓
Thymol Turbidity ↑
Phosphatase ↑
Protein-Bound Iodine ↑
Hematocrit ↓
Hemoglobin ↓
Platelet Count ↓
Red Cell Count ↓
Occult Blood +
Effective Renal Plasma Flow ↓
Alkaline Phosphatase ↑
Bilirubin ↑
Bromosulfophthalein Retention ↑
Inhibits Tubular Reabsorption
Direct Effect on Renal Tubules
Interference with Folin-Ciocalteu Reaction (M)
May Cause Nephrotoxicity
Competes with Phenosulfonphalein for Excretion
Response to Respiratory Alkalosis of Early Toxicity
False + with Clinitest or Benedict's (M)
Reduces Elevated Concentration in Rheumatoid Patients
Low Doses Effect
Acts as Reducing Substance with Non-Specific Methods (M)
High Dose Effect (Greater Than 3g daily)
Occurs with Poisoning
Tubular Epithelial Cells ↑ Initially, May Persist
May Reduce Hyperglycemia, Glycosuria in Diabetes
Due to Hyperglycemia
Occurs with Severe Hemolytic Anemia
By ↑ Oxidation of Ketone Bodies in Diabetics
Acidotic Response Especially in Children
May Cause Nephrotoxicity
Initial Effect Always, May Persist
Conjugate May React with Benedict's (M)
Occurs with Poisoning
Interferes with Fluoro-, Colorimetric Procedures (M)
↓ Renal Tubular Reabsorption
Affects Renal Elimination
Conjugate Inhibits B-Glucuronidase, Dose > 4.8g/day (M)
Prolonged Administration Decreases Concentration in Buffy Coat
Turbidity < Globulins With Sulfosalicylic Acid (M)
If High (M)
Placental Alkaline Phosphatase if From Pitman-Moore or Parke-Davis
Causes Effect if Iodinated
Bone Marrow Depression With Hemolytic Anemia
Bone Marrow Depression With Hemolytic Anemia
Bone Marrow Depression With Hemolytic Anemia
Bone Marrow Depression With Hemolytic Anemia
Melena and Hemorrhagic Gastroenteritis
Occurs in High Percentage of Patients
Due to Hepatocellular Dysfunction
May Cause Hepatocellular Dysfunction
Due to Hepatocellular Dysfunction
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
Antibiotics
Anticoagulants
Ascorbic Acid
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Fecal
Plasma
Urine
Whole Blood
Fecal
Plasma
Fecal
Plasma
Serum
Cephalin Flocculation ↑
Creatine Phosphokinase ↑
Creatinine ↑
Isocitric Dehydrogenase ↑
Magnesium ↓
Non Protein Nitrogen ↑
Potassium ↓
Potassium ↑
SGOT↑
SGPT ↑
Sodium ↓
Thymol Turbidity ↑
Urea Nitrogen ↑
Creatinine Clearance ↓
Glomerular Filtration Rate ↓
Magnesium ↑
Myoglobin ↑
Protein ↑
UA Bile ↑
UA Casts ↑
UA Hemoglobin ↑
UA Protein ↑
UA RBC/ High Power Field ↑
Urobilinogen ↓
Prothrombin Time ↑
Urobilinogen ↓
Coagulation Time ↑
Color ↑
Prothrombin Time ↑
Occult Blood Negative
Catecholamines ↑
Bilirubin ↑
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Cholesterol ↓
Cholesterol ↑
Creatinine ↑
Glucose ↓
Glucose ↑
Glucose ↑
Lactic Dehydrogenase ↓
Due to Hepatocellular Dysfunction
Rhabdomyolysis Cause by Severe Hypokalemia
Nephrotoxic Effect
Due to Hepatocellular Dysfunction
(Occasional) Associated with Toxic Effect of Drug
Nephrotoxic Effect
(Frequent) Associated with Renal Damage
May Occur with Renal Toxicity
Hepatotoxicity Reported
Hepatotoxicity Reported
Significant Effect Even in Normal Subjects
Due to Hepatocellular Dysfunction
Nephrotoxic Effect
Nephrotoxicity Effect (Up to 39%)
Occurs in High Percentage of Patients
Following IV Infusion for 2 Hours
Caused by Rhabdomyolysis
Nephrotoxic Effect
Reported Hepatotoxicity
Granular and Hyaline Casts with Toxicity
Nephrotoxicity, Bleeding Actually Caused by Drug
Nephrotoxicity
Nephrotoxicity
Inhibit G.I. Tract Flora
↓ Synthesis of Vitamin K by G.I. Tract
Inhibit G.I. Tract Flora
Therapeutic Intent
Red to Black Due to Internal Bleeding
Therapeutic Intent
Interferes with Analytic Methods (M)
Concentrated Solutions Cause Striking Fluorescence (M)
At Therapeutic Concentration May Affect Sequential Multiple
Analyzer 12/60 Method (M)
Tends to Fall in People Under 25 When 1g/ Day Given
When Atherosclerotic, Possible/ Unknown Mobilization From Arteries
Chromogenicity in Color Reaction (Acts as Reducing Agent) (M)
Slight Effect With Coupled Glucose Oxidase Method (M)
At 1 mmol/L Affects Sequential Multiple Analyzer 12/60 Method (M)
Affects Alkaline Perricyanide Methods (M)
At Therapeutic Concentration May Depress Sequential Multiple
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
Serum
Serum
Serum
Serum
Serum
Obtained During
Test Conditions
Urine
Urine
Atropine
Bacitracin
Bisacodyl
Calcium Chloride
Calcium Gluconate
Chloral Hydrate
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Whole Blood
Other Bodily Fluid
Serum
Serum
Urine
Urine
Serum
Urine
Urine
Urine
Urine
Urine
Fecal
Serum
Whole Blood
Serum
Urine
Urine
Plasma
Plasma
Serum
Urine
Phenylalanine ↓
SGOT↑
Triglycerides ↓
Tyrosine ↓
Uric Acid ↑
Protein ↑
Analyzer 12/60 Value (M)
Reduces Elevated Level of Premature Infants
At 1 mmol/L Affects Sequential Multiple Analyzer 12/60 Method (M)
Effect Observed in Atherosclerotic Patients
Reduces Elevated Level of Premature Infants
Measured as Reducing Substance (M)
Reacts With Folin-Ciocalteu of Lowry Procedure (M)
Creatine ↑
Glucose ↓
Acts as Reducing Agent (M)
Impaired Color Development of Chromogen in Glucose
Oxidase Method (M)
Porphobilinogen ↓
Inhibition of Color Develop if No Prior Separation (M)
Sugar ↑
False + With Benedict's and Clinitest (M)
Uric Acid ↑
Measured as Reducing Substance (M)
UA Glucose ↓
May Inhibit Testapea and Clinistix (M)
UA Hemoglobin ↓
In Large Amounts Inhibits Guaic Test (M)
Urobilinogen ↓
Lowered pH Reduces Excretion
17 Hydroxy Corticosteroids ↑
Interferes With Method of Reddy (M)
White Cell Count ↑
May Cause Leukocytosis (In Children)
Gastric Juice Hydrochloric Acid ↓ Volume Also Reduced
Barbiturate ↑
False + Screen Test with Mercury Complex Form
Glucose ↓
Possible Slight Fall if Given as Premedication
Phenolsulfonphthalein Excretion ↓ Interferes With Secretion by Tubules
Volume ↓
Very Large Doses Cause Release of Antidiuretic Hormone
Urea Nitrogen ↑
Renal Toxicity (Especially if Given IV)
Protein ↑
May Cause Nephrotoxicity
UA Casts ↑
Nephrotoxic Effect (Cylindruria May Occur)
UA Hemoglobin ↑
Actual Bleeding Caused by Drug
UA Protein ↑
Nephrotoxic Effect
UA RBC/ High Power Field ↑
Actual Bleeding Caused by Drug
Fat ↑
May Cause Steatorrhea if Protracted Ingestion
Potassium ↓
Associated with Steatorrhea if Used in Excess
pH ↓
Acidifying Salt
Magnesium ↓
False ↓ if Measured by Titan-Yellow (M)
Magnesium ↓
False ↓ if Measured by Titan-Yellow (M)
17 Hydroxy Corticosteroids ↓
Reduced Value Reported in a Single Case (M)
Prothrombin Time ↓
Accelerates Rate of Inactivation of Coumarins
Prothrombin Time ↑
Displaces Anticoagulants From Albumin
Urea Nitrogen ↑
Reacts with Nessler Reaction (M)
Catecholamines ↑
Interferes with Fluorometric Procedures (M)
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
Chlorpromazine
Urine
Urine
Urine
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Cerebrospinal Fluid
Fecal
Plasma
Plasma
Plasma
Plasma
Plasma
Plasma
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
ODTC
Urine
Urine
Porphyrins ↑
UA Sugar ↑
17 Hydroxy Corticosteroids ↑
Eosinophils ↑
Hematocrit ↓
Hemoglobin ↓
Monocytes ↑
Platelet Count ↓
Red Cell Count ↓
White Cell Count ↓
Protein ↑
Urobilinogen ↓
Catecholamines ↑
Effective Renal Plasma Flow ↑
Growth Hormone ↓
Norepinephrine ↑
Prolactin ↑
Prothrombin Time ↑
Alkaline Phosphatase ↑
Beta-Glucuronidase ↑
Bilirubin ↑
Bromosulfophthalein Retention ↑
Cholesterol ↑
Coombs Test +
Creatine Phosphokinase ↑
Direct Bilirubin ↑
Glucose ↑
Glucose Tolerance ↓
Haptoglobin ↓
Isocitric Dehydrogenase ↑
Protein-Bound Iodine ↓
Phospholipids ↑
SGOT↑
SGPT ↑
Thyroxine (T4) ↓
Uric Acid ↓
Vitamin B12 ↓
Urea Nitrogen ↑
Estrogens ↑
Gonadotropins ↓
May Precipitate Attack of Acute Porphyria
Excreted as Glucuronide, Reduces Benedict's (M)
Interferes with Porter-Silber Reaction (M)
Often Precursor of Jaundice
Hemolytic Anemia
Hemolytic Anemia
Occasionally Before Agranulocytosis
Associated with Purpura and Pancytopenia
Hemolytic Anemia
Agranulocytosis/Leukopenia/Granulocytopenia
Reacts as if Phenol with Folin-Ciocalteu Reagent (M)
Pale Stools, Due to Cholestasis
↑ Metabolism, ↓ Organ Uptake of Norepinephrine
Slight ↑ in Renal Blood Flow
Probably Inhibits Secretion of Pituitary Growth Hormone
↑ Metabolism, ↓ Organ Uptake
Marked ↑ in Normal in 2 Hours
Associated with Failure of Excretion of Bile Salts
Hepatic Sensitivity to Drug (In Up to 2% of Patients)
Result of Toxic Hepatitis
Sensitivity Reaction (May Cause Jaundice in Infant)
Induces Transient Cholestatic Hepatitis (1 Case)
Associated with Hepatocanalicular Cholestatic Jaundice
Immunological Response to Drug
May be Due to Injection Only (Occurs in 20%)
Sensitivity Reaction to Drug (In Up To 2% of Patients)
Abnormally High with Repeated Doses
Abnormal Curves in 40% of Patients
Hemolytic Anemia
May be Hypersensitive Reaction
Mechanism Obscure (Observed if Over 600mg Given)
May Cause Xanthomatous Biliary Cirrhosis
Hepatic Sensitivity to Drug (In Up to 2% of Patients)
May be Damage of Biliary Canaliculi
Increased Metabolism by Hepatic Microsomes
Uricosuric Action Within 2-3 Days
Possible Inhibition Effect on Some Strains of E. Gracilis (M)
Produces Turbidity with Berthelot's Reagent (M)
Blocks Ovulation, Maintains Decidual Reaction
Blocks Ovulation, Maintains Decidual Reaction
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
Clindamycin
Copper
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Metanephrines Total ↑
Phenylketones +
Porphobilinogen ↑
Pregnancy Tests +
Progestins ↓
Uric Acid ↑
UA Bile ↑
UA Protein ↑
Urobilinogen ↓
Urobilinogen ↑
Vanillylmandelic Acid ↑
Volume ↑
17 Ketogenic Steroids ↑
17 Ketosteroids ↓
Urine
Urine
Urine
17 Ketosteroids ↑
17 Ketosteroids ↑
17 Hydroxy Corticosteroids ↓
Urine
Urine
Whole Blood
Whole Blood
Serum
Serum
Serum
Serum
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Erythrocyte
Erythrocyte
Erythrocyte
Erythrocyte
Erythrocyte
Erythrocyte
Erythrocyte
17 Hydroxy Corticosteroids ↑
5 Hydroxy Indoleacetic Acid ↓
Eosinophils ↑
White Cell Count ↓
Alkaline Phosphatase ↑
Bilirubin ↑
SGOT↑
SGPT ↑
Hematocrit ↓
Hemoglobin ↓
Methemoglobin ↓
White Cell Count ↑
G6PD ↓
Hexokinase ↓
Phosphofructokinase ↓
Phosphoglyceric Kinase ↓
Pyruvate Kinase ↓
Reduced Glutathione ↓
6-Phosphoglycerate
Dehydrogenase ↓
Hemoglobin ↑
Plasma
Interference in Pisano Procedure (M)
Light Purple with Ferric Chloride, Same with Phenistix (M)
Reacts with Ehrlich's Aldehyde Reagent (M)
Gives False + with Frog, Rabbit and Immunology Test (M)
Blocks Ovulation, Maintains Decidual Reaction
Uricosuric Action Reported
Alleged Interference with Bili-Labstix (M)
Affects Turbidity Tests For Up to 3 Days (M)
May be Cholestasis
Reacts with Ehrlich's Aldehyde Reagent (M)
↑ Metabolism and ↓ Organ Uptake of Norepinephrine
Depresses Antidiuretic Hormone Secretion or Water Reabsorption
Interferes with Zimmerman Reaction (M)
Inhibition of Hypothalamus and ↓ Adrenocorticotropic
Hormone Secretion
Interferes with Zimmerman Reaction (M)
Alters Steroid Metabolism
Inhibition of Hypothalamus and ↓ Adrenocorticotropic
Hormone Secretion
Interferes with Porter-Silber Reaction (M)
Interferes with Method of Goldenberg (M)
Occasional Allergic Response
May Cause Agranulocytosis
Transient Abnormality Noted
Occurs Especially if Preexisting Liver Disease
Transient Abnormality Noted
Mild Transient Rises Seen
With Hemolysis of Copper Toxicity
May be Marked Decrease
May Occur with Copper Toxicity
Leukocytosis Observed with Poisoning
Strongly Inhibited (No Activity at 100UM) in Vitro
Very Sensitive to Inhibition by Copper in Vitro
Severely Affected in Vitro
Less Marked Inhibition in Vitro
Severely Affected in Vitro
Marked ↓ with Hemolysis of Toxicity
Strongly Inhibited by Addition of Copper
May Occur with Hemolysis of Toxicity
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
Plasma
Serum
Serum
Serum
Serum
Serum
Diazepam
Digoxin
Diphenhydramine
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Urine
Urine
Urine
Urine
Whole Blood
Whole Blood
ODTC
ODTC
Serum
Serum
Serum
Serum
Erythrocyte
Erythrocyte
Erythrocyte
Urine
Urine
Whole Blood
Whole Blood
Whole Blood
Plasma
Serum
Serum
Methemoglobin ↑
Acid Phosphatase Total ↓
Arginase ↑
Bilirubin ↑
Bromosulfophthalein Retention ↑
Calcium ↑
Occurs with Acute Intravascular Hemolysis
Cupric Ions Inhibit Red Cell Enzyme (M)
Increased when Hemolytic Crisis Occurs
Marked ↑ with Hemolysis of Toxicity
↑ with Hemolytic Crisis
Interferes with Ethylenediaminetetraacetic Acid
Titration Procedures (M)
Cephalin Flocculation ↑
Transient Effect in Poisoning
Ceruloplasmin ↑
Observed with Copper Poisoning
Copper ↑
May be Normal in Toxic Cases with Hemolysis
Haptoglobin ↓
May be Hemolysis with Poisoning
Lactic Dehydrogenase ↑
Toxic Effect, Sharp ↑ with Hemolytic Crisis
Protein-Bound Iodine ↓
As Contaminant of Water May Affect Analysis (M)
SGOT↑
Toxic Effect, Sharp ↑ with Hemolytic Crisis
SGPT ↑
Toxic Effect, Sharp ↑ with Hemolytic Crisis
Sodium ↑
May Interfere with Flame Photometry (M)
Copper ↑
Observed with Poisoning
UA Color ↑
Blue Diapers (Alkaline Urine on Copper Fastenings) (M)
UA Hemoglobin ↑
False + with Guaiac and Benzidine Tests (M)
UA Hemoglobin ↑
May Occur with Copper Toxicity
Neutrophils ↓
Transitory Neutropenia Reported
White Cell Count ↓
Leukopenia
Gastric Juice Hydrochloric Acid ↓ Presumed Central Action Lasts for 5 Hours After 10mg
Gastric Juice Volume ↓
Presumed Central Action Lasts for 5 Hours After 10mg
Bilirubin ↑
Presumed Hepatic Toxic Effect
Iodine 131 Uptake ↓
Conflicting Reports, Unknown Effect
Triiodothyronine Uptake ↓
Resin Test Affected
Dihydroxyphenylalanine
Very Slight Purple Color Produced (M)
Screen Test +
Potassium ↓
6% Drop Within 2 Days, Affects Membrane ATP-ASZ
Sodium ↑
16% ↑, Due to Effect on Membrane ATP-ASE
Water ↑
Slight Effect Only Due to Action on Membrane
17 Ketosteroids ↓
Slight Effect on Zimmerman Reaction in Vitro (M)
17 Hydroxy Corticosteroids ↑
Moderate Effect with in Vitro Test (M)
Hematocrit ↓
Hemolytic Anemia
Hemoglobin ↓
Hemolytic Anemia
Red Cell Count ↓
Hemolytic Anemia
Ammonia ↓
Reported Effect in Exogenous NH3 Toxicity
Bilirubin ↑
May Occur with Hemolytic Anemia
Haptoglobin ↓
May Occur with Hemolytic Anemia
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
Dopamine
Fentanyl
Fibrin Hydrolysate
Fluorescein
Furosemide
Glucose
Urine
Plasma
Plasma
Serum
Whole Blood
Plasma
Serum
Urine
Urine
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Plasma
Plasma
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Whole Blood
Plasma
Plasma
Plasma
Serum
Serum
Serum
Sodium ↑
Epinephrine ↑
Norepinephrine ↓
Amylase ↑
Hemoglobin ↓
Ammonia ↑
Phosphate ↓
UA Color ↑
Urobilin ↑
Hematocrit ↓
Hemoglobin ↓
Platelet Count ↓
Red Cell Count ↓
White Cell Count ↓
Ammonia ↑
Insulin ↓
Amylase ↑
Calcium ↓
Chloride ↓
Glucose ↑
Glucose Tolerance ↓
Potassium ↓
Sodium ↓
Urea Nitrogen ↑
Uric Acid ↑
Calcium ↑
Chloride ↑
Glomerular Filtration Rate ↓
Glucose ↑
Potassium ↑
Sodium ↑
UA Glucose ↑
Volume ↑
Sedimentation Rate ↓
Ammonia ↑
Growth Hormone ↑
Insulin ↑
Alanine ↑
Amino Acids ↓
Arginine ↓
Diuretic Effect
Mechanism Obscure
Mechanism Obscure
May Cause Spasm of Sphincter of Oddi
Possibly Due to Septicemia or Hypophosphatemia
Due to High Ammonia Content of Solution
Intracellular Transfer
I.V. Administration May Cause Yellow-Orange Color
Produces Yellow-Green Fluorescence
May Cause Anemia
May Cause Anemia
May Be Associated with Purpura
May Cause Anemia
May Cause Leukopenia or Aplastic Anemia
Acts Like Thiazides Causes Hypokalemia & Alkalosis
I.V. Injection Effect, Little on Blood Sugar
May Induce Mild Pancreatitis
Diuretic Action (Different Effect Hydrochlorothiazide)
Diuretic Action (Inhibits Tubular Reabsorption)
Diabetogenic-Like Action of Drug: Affects GTT
Diabetogenic-Like Action of Drug
Diuretic Action
Diuretic Action with Sodium Depletion
Possible Nephrotoxic Effect (Reversible) Usually Dehydration
↓ Urate Clearance
Impaired Reabsorption (Initial Effect Only)
Diuretic Action
Excessive Diuresis May Cause Effect
Diabetogenic-Like Action of Drug
Diuretic Action
Diuretic Action
Due to Hyperglycemia
Diuretic Action
High Blood Sugar Lowers Sedimentation Rate (M)
May ↑ as Glucose ↑ in Cirrhotics
Delayed Rise After Initial Slight Fall
Marked Rise Immediately After Oral or I.V. Administration
Rise Related to Gluconeogenesis After Load
(Some Affected Only) - Deposited in Muscle
Probable Muscle Uptake
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
Haloperidol
Heparin
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Whole Blood
Whole Blood
Whole Blood
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Urine
Whole Blood
Whole Blood
Calcium ↓
Chloride ↓
Creatinine ↑
Isoleucine ↓
Leucine ↓
Non Esterified Fatty Acids ↓
Non Esterified Fatty Acids ↑
Osmolality ↑
Phenylalanine ↓
Phosphate ↓
Potassium ↓
Threonine ↓
Urea Nitrogen ↓
Uric Acid ↓
Uric Acid ↑
Valine ↓
Estriol ↓
Insulin ↑
Osmolality ↑
Potassium ↓
Uric Acid ↑
Xylose Excretion ↑
17 Ketogenic Steroids ↓
17 Ketosteroids ↓
Red Cell Count ↓
White Cell Count ↓
White Cell Count ↑
Alkaline Phosphatase ↑
Bilirubin ↑
Bromosulfophthalein Retention ↑
Cephalin Flocculation ↑
Cholesterol ↓
Desmosterol ↑
Glucose ↓
SGOT↑
SGPT ↑
Thymol Turbidity ↑
UA Bile ↑
Clotting Time ↑
Factor IX ↓
May Fall by 0.5 meq/L During GTT
Dilutional Effect When Infused
Interferes with Jaffe Reaction (M)
Probable Muscle Uptake
Probable Muscle Uptake
Effect Greater in Normal Than in Diabetics
Delayed Rise 3 Hours After Administration
Osmotically Active Constituent in Samples (M)
Probable Muscle Uptake
During GTT, Less Marked and Longer Than Calcium
Shift Intracellularly When Infusion Given
Probable Muscle Uptake
Protein Sparing Effect of Glucose and Hemodilution
↑ Urate Clearance Also Seen in Diabetics
Reducing Substance Reacts with Phosphotungstate (M)
Probable Muscle Uptake
Interference with Gas Liquid Chromatography Method (M)
Occurs 3 Hours After Glucose Load
Osmotically Active Constituent in Samples (M)
After Oral Glucose and Fall in Serum Concentration
Infusions Have Uricosuric Action
Interferes with Bromoaniline Procedure if Over 2g/100mL (M)
Interferes with Norymberski Reaction (M)
Interferes with Zimmerman Reaction (M)
May Cause Anemia
May Cause Anemia
Rarely Reported Leukocytosis
May Cause Hepatocellular Changes
May Cause Hepatocellular Changes
May Cause Hepatocellular Changes
May Cause Hepatocellular Changes
Inhibits Cholesterol Biosynthesis
Further Metabolism Inhibited SO Accumulates
Insulin Like Action of Drug Reported in One Case
May Cause Hepatocellular Changes
May Cause Hepatocellular Changes
May Cause Hepatocellular Changes
May Cause Hepatocellular Changes
Concentration Related Effect
Reported Effect
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
Hydroxyzine
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Plasma
Plasma
Plasma
Plasma
Plasma
Plasma
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Urine
Urine
Urine
Plasma
Factor V ↓
Factor XI ↓
Platelet Count ↓
Partial Thromboplastin Time ↑
Thrombin Time ↑
Thromboplastin Gen ↓
Ammonia ↑
Corticosteroids ↑
Insulin ↓
Insulin ↑
Prothrombin Time ↑
Thyroid Stimulating Hormone ↓
Albumin ↑
Bromosulfophthalein Retention ↑
Calcium ↓
Calcium ↑
Cholesterol ↓
Cholesterol ↑
Creatine Phosphokinase ↓
Free Thyroxine ↑
Glucose ↑
Hydroxybutyric Dehydrogenase ↓
Lipoprotein Electrophor +
Lipoprotein Lipase ↑
Non Esterified Fatty Acids ↑
Phosphate ↑
Potassium ↑
Prebeta-Lipoproteins ↓
Sodium ↓
Sodium ↑
Thymol Turbidity ↑
Thyroxine (T4) ↓
Triglycerides ↓
Triiodothyronine (T3) ↑
Triiodothyronine (T3) Uptake ↑
Zinc Sulfate Turbidity ↑
Aldosterone ↓
Sodium ↑
5 Hydroxy Indoleacetic Acid ↓
Prothrombin Time ↑
Concentration Related Effect
Concentration Related Effect
Reported Effect Following IV Infusions
Concentration Related Effect
Related to Concentration of Circulating Heparin
Abnormal Response (Inhibition)
Contains Variable Amounts of Ammonium Salts (M)
If Contaminated by Impurities (M)
Effect in Heparinized Plasma and Serum (M)
Spuriously High Values Reported For Immunoassay (M)
Concentration Related Effect
Interferes with Thyroxine Binding to Protein
Promotes Binding of Haba Dye to Globulins (M)
Color Intensity ↑ in Serum, Wavelength Shifted (M)
Interferes with EDTA and Fluorometric Methods (M)
If Calcium Salt Used May Affect Result (M)
Mechanism Not Detailed
Rebound Effect of Cessation of Treatment
Reported Effect (M)
Probable Modification of Thyroxine Binding
Single Report of Rise of 30 mg/ 100 mL
Significant Inactivation (M)
Alters Electrophoretic Pattern (M)
Release of Tissue Lipase Into Plasma
Also Occurs with Situational Stresses
Phosphate Contamination of Heparin Reported (M)
↓ Renal Excretion
Non-Sustained Response to Small IV Injection
↑ Excretion Due to Aldosterone Suppression
If Sodium Salt Used May Affect Result (M)
Affects Physico-Chem Properties Altering Turbidity (M)
Probable Modification of Thyroxine Binding
Prompt ↓ When Small Dose Given IV
Interferes with Thyroxine Binding to Protein
Red Cell Uptake ↑, Resin Unaffected
Affects Physico-Chem Properties (M)
Suppressed Secretion with Protracted Treatment
Due to Aldosterone Suppression
Reduction in Single Case Carcinoid Syndrome
Prolongs Action of Anticoagulants
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
Insulin
Lactobacillus
Lidocaine
Mafenide
Magnesium Salts
Mannitol
Urine
Urine
Urine
Plasma
Plasma
Plasma
Plasma
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Urine
Urine
Urine
Urine
Plasma
Cerebrospinal Fluid
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Urine
Urine
Urine
Urine
Urine
Urine
Serum
Serum
Serum
17 Ketogenic Steroids ↑
17 Hydroxy Corticosteroids ↑
17 Hydroxy Corticosteroids ↑
Alpha Amino Nitrogen ↓
Corticosteroids ↑
Corticotrophin ↑
Epinephrine ↑
Cholesterol ↓
Creatine Phosphokinase ↑
Glucose ↓
Magnesium ↓
Non Esterified Fatty Acids ↓
Protein-Bound Iodine ↑
Phosphate ↓
Potassium ↓
Protein ↑
Thymol Turbidity ↑
Amino Acids ↓
Amino Acids ↑
UA Ketones ↑
Vanillylmandelic Acid ↑
Ammonia ↓
Protein ↑
PCO2 ↓
pH ↓
pH ↑
White Cell Count ↓
Ammonia ↓
Bicarbonate ↑
Chloride ↓
pH ↑
Potassium ↑
UA pH ↑
Alkaline Phosphatase ↑
Calcium ↓
Calcium ↑
Serum
Urine
Serum
Magnesium ↑
Diagnex Blue Excretion ↑
Chloride ↓
Interferes with Zimmerman Reaction (M)
Affects Modified Glenn-Nelson Method
Interferes with Porter-Silber Reaction (M)
↑ Uptake by Tissues
Significant Effect at 40 Minutes, Maximal at 60 Minutes
Response to Stress
Stimulation of Adrenal Medulla, Possible by Hypoglycemia
Therapeutic Goal
Is an Activator of Enzyme
Natural Action of Hormone
Effect Seen in Treatment of Diabetic Coma
Effect Similar in Normal and Diabetics
Mechanism Obscure
Increased Phosphorylation of Glucose
Therapeutic Effect, Causes Intracellular Shift
Associated with Increased Protein Synthesis
Associated with Increased Protein Synthesis
Metabolic Effects
Metabolic Effects
Occurs Especially if low Liver Glycogen Stores
↑ After Insulin Shock, None with Normal Dose
Causes Reduction in Hepatic
Reacts with Folin-Ciocalteu Reagent (M)
Inhibition of Carbonic Anhydrase When Applied Topically
If Respiratory Impairment as Reduced Renal Buffering
Usual Finding with Respiratory Alkalosis
Probable Effect Observed in One Child
Inhibition of Carbonic Anhydrase When Applied Topically
Inhibition of Carbonic Anhydrase When Applied Topically
Selective Retention
Inhibition of Carbonic Anhydrase When Applied Topically
Inhibition of Carbonic Anhydrase When Applied Topically
Inhibition of Carbonic Anhydrase When Applied Topically
Activators of Enzyme in Laboratory Procedures (M)
Competes with Calcium for GI Tract Absorption
Measured as Calcium in Some
Ethylenediaminetetraacetic Acid Procedures (M)
Absorbed From GI Tract From Antacids
Heavy Metal Displacement of Diagnex Blue
Effect if Marked Diuresis
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
Methadone
Metronidazole
Mineral Oil
Nafcillin
Nicotine
Nitrofurantoin
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Urine
Whole Blood
Serum
Whole Blood
Whole Blood
Urine
Urine
Plasma
Serum
Serum
Serum
Plasma
Serum
Serum
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Creatinine ↑
Osmolality ↑
Phosphate ↓
Potassium ↑
Sodium ↓
Sodium ↑
Uric Acid ↓
Sodium ↑
PCO2 ↑
Bromosulfophthalein Retention ↑
Neutrophils ↓
White Cell Count ↓
UA Color ↑
17 Ketogenic Steroids ↓
Prothrombin Time ↑
Carotene ↓
Bromosulfophthalein Retention ↑
SGOT↑
11 Hydroxy Corticosteroids ↑
Glucose ↑
Non Esterified Fatty Acids ↑
Eosinophils ↑
Heinz-Body Formation +
Hematocrit ↓
Hemoglobin ↓
Mean Corpuscular Volume ↓
Methemoglobin ↑
Platelet Count ↓
Red Cell Count ↓
White Cell Count ↓
Alkaline Phosphatase ↑
Bilirubin ↑
BSP Retention ↑
Cephalin Flocculation ↑
CO2 Content ↓
Creatinine ↑
Glucose Tolerance ↓
Haptoglobin ↓
Lactic Dehydrogenase ↑
Non Protein Nitrogen ↑
Due to Dehydration
May Cause Marked Dehydration
Inhibition of Color Development (M)
Mechanism Not Detailed
Effect if Marked Diuresis
May Cause Marked Dehydration
Reported to Have Uricosuric Action
Slight Increase Occurs Only
May Cause Diminished Pulmonary Ventilation
Hepatotoxic Effect or Spasm of Sphincter of Oddi
Transient Neutropenia May Occur
Leukopenia and Reduction of Polymorphs
Brown Color Probably Due to Metabolite (M)
If Previously Elevated, Possibly Depresses Adrenal Cortex
Inhibits Absorption of Vitamin K
Reduced Absorption (May be 50% Normal)
Reported Effect (Possibly Hepatotoxicity)
Possibly Due to Trauma of Injection
Up To 80% ↑ After Heavy Smoking
Due to Adrenal Response in Poisoning
Probable Stress Response
Allergic Response (Greater Than 1%)
May Cause Hemolytic Anemia
Megaloblastic Anemia/Hypersensitivity (G6PD)
Megaloblastic Anemia/Hypersensitivity (G6PD)
Megaloblastic Anemia/Hypersensitivity (G6PD)
May Cause Hemolysis with G6PD Deficiency
Thrombocytopenia
Hypersensitivity (G6PD)/ Megaloblastic Anemia
Leukopenia/ Agranulocytosis May Occur
May Cause Cholestatic Jaundice
May Cause Hemolytic Anemia of Cholestasis
Intrahepatic Cholestatic Jaundice
May be Cholestatic Jaundice
Nephrotoxicity May Cause Azotemia
Nephrotoxic Effect
Single Case Reported
Hemolytic Effect
May Cause Hemolytic Anemia
Nephrotoxic Effect
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
Nystatin
Oxandrolone
Phenols
Phytonadione
Potassium
Potassium Chlorate
Serum
Serum
Serum
Serum
Serum
Urine
Urine
Urine
Urine
Urine
Urine
Whole Blood
Whole Blood
Plasma
Plasma
Serum
Serum
Serum
Serum
Serum
Serum
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Whole Blood
Whole Blood
Whole Blood
Plasma
Serum
Urine
Urine
Plasma
Serum
Serum
Whole Blood
Serum
SGOT↑
SGPT ↑
Thymol Turbidity ↑
Urea Nitrogen ↑
5-Nucleotidase ↑
Alkaline Phosphatase ↓
Lactic Dehydrogenase ↓
Sugar ↑
UA Bile ↑
UA Color ↑
Urobilinogen ↑
Eosinophils ↑
Platelet Count ↓
Fibrinogen ↑
Plasminogen ↑
Bromosulfophthalein Retention ↑
Cholesterol ↓
Glucose ↓
Haptoglobin ↑
Sialic Acid ↑
Triglycerides ↓
Phenylketones +
UA Casts ↑
UA Color ↑
UA Hemoglobin ↑
UA Protein ↑
UA RBC/ High Power Field ↑
UA Sugar ↑
Hematocrit ↓
Hemoglobin ↓
Red Cell Count ↓
Prothrombin Time ↓
Bilirubin ↑
UA Hemoglobin ↑
UA RBC/ High Power Field ↑
Ammonia ↓
Calcium ↑
Sodium ↑
Methemoglobin ↑
Chloride ↑
May Cause Cholestatic Jaundice
May Cause Cholestatic Jaundice
May Be Cholestatic Jaundice
Possible ↓ in Already Impaired Renal Function
Due to Cholestasis
Interference with Determination Method (M)
Interference with Determination Method (M)
Metabolites May Reduce Benedict's, Yield False + (M)
May Cause Cholestatic Jaundice
Brown, Yellow Color (M)
Intrahepatic Cholestatic Jaundice
May Cause Allergic Reaction
Thrombocytopenia (AMA-Blood Dyscrasias)
Metabolic Effect
Metabolic Effect
Slight ↑ in One Child
Anabolic Effect
Anabolic Effect
Metabolic Effect
Metabolic Effect
↑ Triglyceride Hydrolysis Peripherally
Violet with Ferric Chloride, Nil With Phenistix (M)
Nephrotoxicity With Poisoning (Usually RBC Casts)
Dark Green to Brownish Black on Standing (M)
Nephrotoxicity With Poisoning
Nephrotoxicity With Poisoning
Occur With Renal Damage of Poisoning
Interferes With Benedict’s Reagent
Hemolysis May Occur with G6PD Deficiency
Hemolysis May Occur with G6PD Deficiency
Hemolysis May Occur with G6PD Deficiency
Stimulates Synthesis of Clotting Factors
Large Dose Effect, or with G6PD Deficiency
Actual Bleeding Caused by Drug
Actual Bleeding Caused by Drug
Potassium Repletion in Hepatic Coma May Reduce Ammonia
Affects Flame Photometry if Poor Instrument (M)
Affects Flame Photometry if Poor Instrument (M)
May Cause Hemolytic Anemia
Added Chloride
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
Prednisolone
Serum
Serum
Whole Blood
Whole Blood
Serum
Glucose ↓
Potassium ↑
White Cell Count ↓
White Cell Count ↑
Protein-Bound Iodine ↓
Drawn Into Cells with Potassium
Over Correction of Hypokalemia
Leukopenia
Leukocytosis Observed Occasionally
Inhibits Iodination of Tyrosine Residues in Thyroxine Binding
Serum
Serum
Urine
Whole Blood
Fecal
Plasma
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Urine
Whole Blood
Plasma
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Serum
Urine
Urine
Potassium ↓
Sodium ↑
Potassium ↑
White Cell Count ↓
Urobilinogen ↓
Prothrombin Time ↑
Alkaline Phosphatase ↑
Bilirubin ↑
Bromosulfophthalein Retention ↑
Cephalin Flocculation ↑
Cholesterol ↑
SGOT↑
SGPT ↑
Thymol Turbidity ↑
Catecholamines ↑
Metanephrines Total ↑
Phenylketones +
UA Bile ↑
Urobilinogen ↓
Vanillylmandelic Acid ↑
17 Hydroxy Corticosteroids ↑
5 Hydroxy Indoleacetic Acid ↓
White Cell Count ↓
Catecholamines ↑
Alkaline Phosphatase ↑
Bilirubin ↑
Bromosulfophthalein Retention ↑
Cephalin Flocculation ↑
Glucose ↑
SGOT↑
SGPT ↑
Thymol Turbidity ↑
Pregnancy Tests Negative
Pregnancy Tests +
Slight Mineralocorticoid Effect
Very Slight Mineralocorticoid Effect
Slight Mineralocorticoid Effect
Agranulocytosis Due to Interference in Development
Pale Stools Associated with Cholestasis
Associated with Impaired Excretion of Bile Salts
Cholestatic Effect
Cholestatic Effect
Cholestatic Effect
Cholestatic Effect
Cholestatic Effect
Cholestatic Effect
Cholestatic Effect
Cholestatic Effect
↑ Metabolism, ↓ Organ Uptake of Norepinephrine
↑ Metabolism, ↓ Organ Uptake of Norepinephrine
Light Purple with Ferric Chloride, Same with Phenistix (M)
Cholestatic Effect
Cholestatic Effect
↑ Metabolism, ↓ Organ Uptake of Norepinephrine
Interferes with Porter-Silber Reaction (M)
Interference with Nitrosonaphthol Methods
Agranulocytosis/ Leukopenia
↑ Metabolism, ↓ Organ Uptake of Norepinephrine
May Cause Cholestasis
May Cause Cholestasis
May Cause Cholestasis
May Cause Cholestasis
If Given I.V. or I.M.
May Cause Cholestasis
May Cause Cholestasis
May Cause Cholestasis
False Negative with Porter-Silber Reaction (M)
False + with Gravindex (M)
Globulin
Prochlorperazine
Promethazine
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
Silver
Sodium
Sodium Bicarbonate
Sodium Chloride
Trimethoprim
Vancomycin
Vitamin A
Urine
Urine
Urine
Whole Blood
Fecal
Serum
Serum
Serum
Whole Blood
Serum
Serum
Urine
Urine
Urine
Serum
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Serum
Whole Blood
Whole Blood
Serum
Urine
Urine
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Whole Blood
Plasma
Serum
Serum
Serum
Serum
UA Bile ↑
17 Hydroxy Corticosteroids ↑
5 Hydroxy Indoleacetic Acid ↓
pH ↑
Occult Blood +
Chloride ↓
Sodium ↓
Potassium ↑
pH ↑
Potassium ↓
Sodium ↑
pH ↑
UA Protein ↑
Urobilinogen ↑
Bilirubin ↓
Hematocrit ↓
Hemoglobin ↓
Mean Corpuscular Volume ↑
Platelet Count ↓
Red Cell Count ↓
Sedimentation Rate ↓
Folate ↓
Eosinophils ↑
White Cell Count ↑
Urea Nitrogen ↑
Protein ↑
UA Protein ↑
Hematocrit ↓
Hemoglobin ↓
Methemoglobin ↑
Neutrophils ↓
Red Cell Count ↓
Sedimentation Rate ↑
White Cell Count ↓
Prothrombin Time ↑
Bilirubin ↑
Cholesterol ↑
Direct Bilirubin ↑
Iodine 131 Uptake ↓
May Cause Cholestasis
Interference With Porter-Silber Reaction (M)
Interference with Nitrosonaphthol Methods (M)
Observed After Silver Nitrate Antiseptics
May Cause Hemorrhagic Gastroenteritis
Observed After Silver Nitrate Antiseptics
Observed After Silver Nitrate Antiseptics
Variable Concentration Affects Most Flame Methods
Affects Acid-Base Balance in Vivo
Causes Potassium to Shift Into Cells
May Cause Sodium Retention
Used to Alkalinize Urine
False + with Labstix Due to High pH (M)
↑ Clearance When Urine is Alkaline
Inhibition of Diazo Test Reported (M)
Folic Acid Antagonist Possible Megaloblastic Anemia
Folic Acid Antagonist Possible Megaloblastic Anemia
Occurs With Megaloblastic Anemia
Most Common Serious Toxic Effect
Folic Acid Antagonist Possible Megaloblastic Anemia
With Sulfa Caused Marked ↓ in Rheumatoids
Usually with Sulfa - No Hematological Abnormality
Allergic Response
Due to Eosinophilia
Nephrotoxic Effect (May be Fatal)
Nephrotoxicity May Occur
Nephrotoxicity May Occur
Anemia Observed
Anemia Observed
May Cause Hemolysis with G6PD
Leukopenia with Hypoplastic Anemia Reported
With Excessive Doses and Use
Observed Effect with Unknown Explanation
Leukopenia with Hypoplastic Anemia Reported
Hemorrhagic Trend Experienced if Vitamin K is Restricted
Interferes with Analysis (M)
Interferes with Zlatkis-Zak Reaction (M)
Interferes with Analysis (M)
Significant Effect When Administered for 3 Weeks
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
Serum
Protein-Bound Iodine ↓
Inhibits Iodination of Tyrosine Residues in Thyroxine Binding
Serum
Serum
Urine
Serum
Protein-Bound Iodine ↑
Vitamin A ↑
Magnesium ↑
Alkaline Phosphatase ↓
When Given in Cod Liver Oil
Ingested Compound in Serum
Measured by Fluorometric Method of Schachter (M)
Inhibitors of Enzyme in Laboratory Procedures (M)
Globulin
Zinc
Zinc Salts
SGOT: Serum Glutamic-Oxalacetic Transaminase; SGPT: Serum Glutamic-Pyruvic Transaminase; UA: Urinalysis; G6PD: Glucose6-Phosphate Dehydrogenase; RBC: Red Blood Cell; ODTC: Obtained During Test Conditions; + = Positive
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