BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Miao, Yubin
Assistant Professor
eRA COMMONS USER NAME
YBMIAO
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Beijing Normal University, Beijing P. R. China
Beijing Normal University, Beijing P. R. China
Beijing Normal University, Beijing P. R. China
University of Missouri, Columbia, MO USA
DEGREE
(if
applicable)
YEAR(s)
FIELD OF STUDY
B.S.
M.S.
Ph.D.
Postdoc
1988-1992
1992-1994
1994-1997
1999-2003
Chemistry
Radiopharmaceutical Chemistry
Radiopharmaceutical Chemistry
Peptide Radiopharmaceuticals
A. Personal Statement
The objective of Dr. Miao's research is to develop novel cancer-specific radiolabeled peptides for cancer
(melanoma, breast and prostate cancer) imaging and treatment. Dr. Miao has the unique expertise, leadership
and motivation to successfully carry out this exciting translational work. Dr. Miao has his graduate and
postdoctoral training in Radiopharmaceutical Chemistry, with expertise in the development of
radiopharmaceuticals. Dr. Miao has 14 years of experience in peptide design and radiolabeling, in vitro
receptor binding assay, evaluation of the pharmacokinetics of radiolabeled peptides in animal models and
small animal imaging and therapy. Dr. Miao is well published in the area of melanoma imaging and therapy. Dr.
Miao has demonstrated a successful and productive research record in melanoma imaging and therapy, which
has prepared him to lead the proposed project.
B. Positions and Honors
Positions and Employment
July 1997-June 1999
July 1999-Sept. 1999
Oct. 1999-Feb. 2003
Mar. 2003-Mar. 2006
April 2006-present
Lecturer, Department of Chemistry, Beijing Normal University, Beijing, P. R. China.
Associate Professor, Department of Chemistry, Beijing Normal University, Beijing, P.
R. China.
Postdoctoral Fellow, Department of Biochemistry, University of Missouri-Columbia,
Columbia, MO, USA.
Research Assistant Professor, Department of Internal Medicine, University of
Missouri-Columbia, Columbia, MO, USA.
Assistant Professor, College of Pharmacy, University of New Mexico, NM, USA.
Honors
1996
1999-2001
2002
2002
2007
2008
2011
2012
2012-present
Outstanding Ph.D. Candidate Award, Beijing Normal University
Postdoctoral Fellowship of Life Science Mission Enhancement, University of Missouri-Columbia
Beijing Normal University Outstanding Research Achievement Award
Society of Nuclear Medicine Radiopharmaceutical Science Young Investigators Award
American Association of Colleges of Pharmacy New Investigator Award
Department of Defense Breast Cancer Research Program Idea Award
Top newsmaker of 2011 by New Mexico Business Weekly
Travel Award for the 5th Biennial Workshop on Small-Animal SPECT Imaging
Member of NIH Early Career Reviewer Program
Professional Memberships
2006-present Member, Society of Nuclear Medicine
2006-present Member, Society of Radiopharmaceutical Science
2006-present Member, American Association of Colleges of Pharmacy
C. Selected Peer-reviewed Publications (from 53 peer-reviewed publications)
Most relevant to the current application
1.
2.
3.
4.
5.
Jianquan Yang, Haixun Guo, Fabio Gallazzi, R. Steven Padilla, Marianne Berwick, Yubin Miao.
Evaluation of a novel RGD-conjugated alpha-melanocyte stimulating hormone hybrid peptide for potential
melanoma therapy. Bioconjugate Chemistry 2009;20:1634-1642.
Haixun Guo, Jie Lu, Helen J. Hathaway, Melanie E. Royce, Eric R. Prossnitz, Yubin Miao. Synthesis and
evaluation of novel gonadotropin-releasing hormone receptor-targeting peptides. Bioconjugate Chemistry
2011;22:1682-1689.
Haixun Guo, Fabio Gallazzi, Larry A. Sklar, Yubin Miao*. A novel Indium-111-labeled gonadotropinreleasing hormone peptide for human prostate cancer imaging. Bioorganic & Medicinal Chemistry Letters
2011;21:5183-5186.
Haixun Guo, Jianquan Yang, Fabio Gallazzi, Yubin Miao. Effects of the amino acid linkers on melanomatargeting and pharmacokinetic properties of Indium-111-labeled lactam bridge-cyclized α-MSH peptides.
Journal of Nuclear Medicine 2011;52:608-616.
Haixun Guo, Yubin Miao. Cu-64-labeled lactam bridge-cyclized alpha-MSH peptides for PET imaging of
melanoma. Molecular Pharmaceutics 2012;9:2322-2330.
Additional recent publications of importance to the field
6.
7.
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11.
12.
13.
14.
Yubin Miao, Nellie K. Owen, Timothy J. Hoffman, Thomas P. Quinn. Therapeutic efficacy of a 188Re
labeled -melanocyte stimulating hormone peptide analog in murine and human melanoma-bearing
mouse models. Journal of Nuclear Medicine 2005;46:121-129.
Yubin Miao, Mark Hylarides, Darrell R. Fisher, Herbert Moore, Dennis W. Wester, Alan R. Fritzberg,
Richard Testa, Timothy J. Hoffman, Thomas P. Quinn. Melanoma therapy via peptide-targeted α-radiation.
Clinical Cancer Research 2005;11:5616-5621.
Lihui Wei, Clayton Butcher, Yubin Miao, Fabio Gallazzi, Thomas P. Quinn, Michael J. Welch, Jason S.
Lewis. Synthesis and biological evaluation of Cu-64 labeled rhenium-cyclized α-MSH peptide analog using
a cross-bridged cyclam chelator. Journal of Nuclear Medicine 2007;48:64-72.
Yubin Miao, Katherine Benwell, Thomas P. Quinn. 99mTc and 111In labeled alpha-melanocyte stimulating
hormone peptides as imaging probes for primary and pulmonary metastatic melanoma detection. Journal
of Nuclear Medicine 2007;48:73-80.
Yubin Miao, Thomas P. Quinn. Peptide-targeted radionuclide therapy for melanoma. Critical Reviews in
Oncology/Hematology 2008;67:213-228 (Invited review).
Yubin Miao, Said D. Figueroa, Darrell R. Fisher, Herbert A. Moore, Richard F. Testa, Timothy J. Hoffman,
Thomas P. Quinn. 203Pb-labeled alpha-melanocyte stimulating hormone peptide as an imaging probe for
melanoma detection. Journal of Nuclear Medicine 2008;49:823-829.
Yubin Miao, Fabio Gallazzi, Haixun Guo, Thomas P. Quinn. 111In-labeled lactam bridge-cyclized alphamelanocyte stimulating hormone peptide analogues for melanoma imaging. Bioconjugate Chemistry
2008;19:539-547.
Haixun Guo, Jianquan Yang, Nalini Shenoy, Yubin Miao. Gallium-67-labeled lactam bridge-cyclized
alpha-melanocyte stimulating hormone peptide for primary and metastatic melanoma imaging.
Bioconjugate Chemistry 2009;20:2356-2363.
Jianquan Yang, Haixun Guo, R. Steven Padilla, Marianne Berwick, Yubin Miao. Replacement of Lys
linker with Arg linker resulting in improved melanoma uptake and reduced renal uptake of Tc-99m-labeled
Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide. Bioorganic & Medicinal
Chemistry 2010;18:6695-6700.
15. Jianquan Yang, Jie Lu, Yubin Miao. Structural modification on the Lys linker enhanced tumor to kidney
uptake ratios of Tc-99m-labeled RGD-conjugated alpha-MSH hybrid peptides. Molecular Pharmaceutics
2012;9:1418-1424.
D. Research Support
Ongoing Research Support
Department of Defense W81XWH-09-1-0105
Miao (PI)
01/01/2009-01/31/2012
(No-cost-extension to 01/31/2014)
Novel Radiolabeled Peptides Targeting Gonadotropin-releasing Hormone Receptors for Non-invasive Breast
Cancer Imaging
The goal of this study is to develop novel radiolabeled peptides for non-invasive PET imaging of breast cancer.
Role: PI
Completed Research Project (last three years)
Oxnard Foundation Award
Miao (PI)
Novel Radiolabeled Peptides for Non-invasive Prostate Cancer Imaging
The goal of this study is to develop novel peptides for prostate cancer imaging.
Role: PI
02/01/2009-01/31/2012
Southwest Melanoma SPORE Developmental Pilot Project
Miao (PI)
Novel RGD-Conjugated Alpha-MSH Hybrid Peptide for Melanoma Therapy
The goal of this study is to develop novel hybrid peptides for melanoma treatment.
Role: PI
04/01/2009-03/31/2010
American Cancer Society/Institutional Research Grant
Miao (PI)
05/01/2007-03/31/2008
Radiolabeled Peptide for Metastatic Melanoma Detection
The goal of this study is to develop α-MSH peptides for metastatic melanoma detection.
Role: PI