Supplemental Table 1. Wnt Signaling Pathway RT2 Profiler PCR Array results for KSHV
infected HUVEC. The PCR arrays consisted of 84 genes related to WNT-mediated signal
transduction, 5 reference genes, 3 reverse transcription controls and 3 positive controls. Genes
up-regulated in KSHV infected HUVEC compared to mock-infected HUVEC by at least 3 fold
are in red and genes down-regulated 3 fold or more are in green.
Gene symbol
AES
APC
AXIN1
BCL9
BTRC
FZD5
CCND1
CCND2
CCND3
CSNK1A1
CSNK1D
CSNK1G1
CSNK2A1
CTBP1
CTBP2
CTNNB1
CTNNBIP1
CXXC4
DAAM1
DIXDC1
DKK1
DVL1
DVL2
EP300
FBXW11
FBXW2
FGF4
FOSL1
FOXN1
FRAT1
FRZB
Description
Amino-terminal enhancer of split
Adenomatous polyposis coli
Axin 1
B-cell CLL/lymphoma 9
Beta-transducin repeat containing
Frizzled homolog 5 (Drosophila)
Cyclin D1
Cyclin D2
Cyclin D3
Casein kinase 1, alpha 1
Casein kinase 1, delta
Casein kinase 1, gamma 1
Casein kinase 2, alpha 1 polypeptide
c-terminal binding protein 1
c-terminal binding protein 2
Catenin (cadherin-associated protein), beta 1, 88
kDa
Catenin, beta interacting protein 1
CXXC finger 4
Disheveled associated activator of morphogenesis
1
DIX domain containing 1
Dickkopf homolog 1 (Xenopus laevis)
Disheveled, dsh homolog 1 (Drosophila)
Disheveled, dsh homolog 2 (Drosophila)
E1A binding protein p300
F-box and WD repeat domain containing 11
V-box and WD repeat domain containing 2
Fibroblast growth factor 4
FOS-like antigen 1
Forkhead box N1
Frequently rearranged in advanced T-cell
lymphomas
Frizzled-related protein
Fold up- or downRegulation
KSHV infected/Mock
infected
1.18
-1.12
1.36
-1.04
1.79
1.10
5.06
1.45
1.45
2.06
-1.12
-1.47
1.10
-1.20
-1.38
-1.20
-1.47
2.20
-1.47
-1.69
-7.26
2.06
-1.58
-1.04
1.79
1.27
1.03
-9.58
2.71
-2.23
1.27
FSHB
FZD1
FZD2
FZD3
FZD4
FZD6
FZD7
FZD8
GSK3A
GSK3B
JUN
KREMEN1
LEF1
LRP5
LRP6
MYC
NKD1
NLK
PITX2
PORCN
PPP2CA
PPP2R1A
PYGO1
RHOU
SENP2
SFRP1
SFRP4
FBXW4
SLC9A3R1
SOX17
T
TCF7
TCF7L1
TLE1
TLE2
WIF1
WISP1
WNT1
Follicle stimulating hormone, beta polypeptide
Frizzled homolog 1 (Drosophila)
Frizzled homolog 2 (Drosophila)
Frizzled homolog 3 (Drosophila)
Frizzled homolog 4 (Drosophila)
Frizzled homolog 6 (Drosophila)
Frizzled homolog 7 (Drosophila)
Frizzled homolog 8 (Drosophila)
Glycogen synthase kinase 3 alpha
Glycogen synthase kinase 3 beta
Jun oncogene
Kringle containing transmembrane protein1
Lymphoid enhancer-binding factor 1
Low density lipoprotein receptor-related protein 5
Low density lipoprotein receptor-related protein 6
V-myc myelocytomatosis viral oncogene homolog
Naked cuticle homolog 1 (Drosophila)
Nemo-like kinase
Paired-like homeodomain 2
Porcupine homolog (Drosophila)
Protein phosphatase 2 (formerly 2A), catalytic
subunit, alpha isoform
Protein phosphatase 2 (formerly 2A), regulatory
subunit, alpha isoform
Pygopus homolog 1 (Drosophila)
Ras homolog gene family, member U
SUMO1/sentrin/SMT3 specific peptidase 2
Secreted frizzled-related protein 1
Secreted frizzled-related protein 4
f-box and WD repeat domain containing 4
Solute carrier family 9 (sodium/hydrogen
exchanger), member 3 regulator 1
SRY (sex determining region Y)-box 17
T, brachyury homolog (mouse)
Transcription factor 7 (T-cell specific, HMG-box)
Transcription factor 7-like (T-cell specific, HMGbox)
Transducin-like enhancer of split 1 (E(sp1)
homolog, Drosophila)
Transducin-like enhancer of split 2 (E(sp1)
homolog, Drosophila)
WNT inhibitory factor 1
WNT1 inducible signaling pathway protein 1
Wingless-type MMTV integration site family,
member 1
1.03
-1.20
-13.55
-1.12
1.67
2.91
-2.95
-4.79
1.18
1.67
1.27
1.03
1.03
-2.23
-1.82
-1.47
1.03
1.03
1.67
1.10
-1.58
1.45
3.12
2.20
1.56
-3.89
1.03
-1.04
1.10
-1.47
-1.47
1.03
-1.47
-2.95
-1.82
1.03
1.03
1.03
WNT10A
WNT11
WNT16
WNT2
WNT2B
WNT3
WNT3A
WNT4
WNT5A
WNT5B
WNT6
WNT7A
WNT7B
WNT8A
WNT9A
B2M
HPRT1
RPL13A
GAPDH
ACTB
Wingless-type MMTV integration site family,
member 10A
Wingless-type MMTV integration site family,
member 11
Wingless-type MMTV integration site family,
member 16
Wingless-type MMTV integration site family,
member 2
Wingless-type MMTV integration site family,
member 2B
Wingless-type MMTV integration site family,
member 3
Wingless-type MMTV integration site family,
member 3A
Wingless-type MMTV integration site family,
member 4
Wingless-type MMTV integration site family,
member 5A
Wingless-type MMTV integration site family,
member 5B
Wingless-type MMTV integration site family,
member 6
Wingless-type MMTV integration site family,
member 7A
Wingless-type MMTV integration site family,
member 7B
Wingless-type MMTV integration site family,
member 8A
Wingless-type MMTV integration site family,
member 9A
Beta-2 microglobulin
Hypoxanthine phosphoribosyltransferase 1
Ribosomal protein L13a
Glyceraldeyde-3-phosphate dehydrogenase
Actin, beta
1.03
1.03
-1.95
1.03
-1.04
-1.95
1.92
-1.69
1.92
1.03
1.03
18.90
1.03
1.03
-2.08
2.20
-1.58
-2.08
1.27
1.18