The pathway-pathway interaction(s) through 90 cross-talk PPIs were listed.
No. of
cross-talk
Pathway A
Pathway B
Involvement of cross-talk PPIs
PPIs
involvement
Signal
Cell Cycle
16
Transduction
GSK3B-CCND1, CDK2-SMAD3, TP53-FOXO3,
BIRC5-CASP9, PTK2-CCNA1, TP53-SMAD2,
CCNB1-FOXO1, TP53-CREB1, TP53-BCR,
APC-CSNK1E, CDK4-SMAD3, CDK6-CTNNB1,
TP53-STK4, BUB1-EIF4EBP1, BUB1-APC,
CCNE1-GSK3B
Immune System
Hemostasis
16
IL1B-A2M, HSP90AB1-GNAI2, CALR-F8,
MAP3K3-FLNA, ARRB2-PPM1B, ACTN1-CAMK2A,
CAMK2G-FLNA, TP53-FOXO3, TP53-PIAS1,
WEE1-FBXW11, PTK2-PIAS1, HSP90AB1-FLNA,
TP53-CREB1, FADD-RHOA, ARRB2-MAP3K1,
TRAF2-FLNA
Apoptosis
Signal
15
Transduction
BID-RHOA, CASP6-APP, FASLG-PIK3R1,
RALBP1-TRAF2, APPL1-HDAC1, FASLG-FN1,
FASLG-FYN, APPL1-PIK3CA, TNFRSF1A-IKBKB,
FAS-RHOA, FADD-RHOA, CYCS-TRAF6, FAS-PRKCA,
MAPK3-DAPK1, FAS-RAP1A
Apoptosis
Hemostasis
14
BID-RHOA, CASP6-APP, FASLG-PIK3R1,
APPL1-HDAC1, TP53-BAX, FASLG-FN1, FASLG-FYN,
APPL1-PIK3CA, FAS-RHOA, FADD-RHOA,
TRAF2-FLNA, FAS-PRKCA, MAPK3-DAPK1,
FAS-RAP1A
Immune System
Signal
14
Transduction
MAP3K3-MAP2K5, IL1B-A2M, HSP90AB1-GNAI2,
ARRB2-PPM1B, RALBP1-TRAF2, IL6-HRH1,
PTK2-PIAS1, MAP3K7-SMAD3, CAMK2G-SMAD3,
MAP3K14-CASP3, FADD-RHOA, ARRB2-MAP3K1,
RALBP1-IKBKG, CAMK2A-SMAD2
Developmental
Cell Cycle
11
GSK3B-CCND1, TP53-CSNK2A1, CDK2-SMAD3,
Biology
TP53-FOXO3, PTK2-CCNA1, TP53-SMAD2,
CCNB1-FOXO1, TP53-CREB1, CDK4-SMAD3,
CDK6-CTNNB1, CCNE1-GSK3B
Immune System
Developmental
11
Biology
LCK-DLG1, PARK2-DLG1, CBL-MET, RXRA-ZBTB16,
PTK2-PIAS1, RXRA-RELA, MAP3K7-SMAD3,
CAMK2G-SMAD3, FADD-RHOA, FADD-EZR,
CAMK2A-SMAD2
Apoptosis
Immune System
11
CASP6-APP, FASLG-PIK3R1, FASLG-FYN,
APPL1-PIK3CA, PTK2-PIAS1, TNFRSF1A-IKBKB,
MAP3K14-CASP3, CYCS-TRAF6, FAS-PRKCA,
MAPK3-DAPK1, FAS-RAP1A
Apoptosis
Developmental
10
Biology
BID-RHOA, CASP3-MET, FASLG-FYN, APC-CSNK2A1,
FAS-RHOA, APC-CTNNA1, FADD-RHOA,
MAPK3-DAPK1, FADD-EZR, APC-SIAH1
Apoptosis
Cell Cycle
10
APPL1-HDAC1, TP53-BAX, BIRC5-CASP9,
PTK2-CCNA1, APC-CSNK1E, CDK6-CTNNB1,
BID-CSNK1E, MAPK3-DAPK1, OCLN-CSNK1E,
BUB1-APC
Developmental
Signal
Biology
Transduction
9
HSP90AB1-GNAI2, LCK-DLG1, CASP3-MET,
CBL-MET, RXRA-RELA, APC-CSNK2A1,
ARRB2-CTNNA1, APC-CTNNA1, APC-SIAH1
Immune System
Cell Cycle
9
GSK3B-CCND1, MAP3K7-RUVBL1, TP53-FOXO3,
BIRC5-CASP9, TP53-PIAS1, WEE1-FBXW11,
CCNB1-FOXO1, TP53-CREB1, CCNE1-GSK3B
Developmental
Hemostasis
9
Biology
HSP90AB1-GNAI2, LCK-DLG1, TP53-CSNK2A1,
CDK2-SMAD3, TP53-FOXO3, TP53-SMAD2,
HSP90AB1-FLNA, TP53-CREB1, ARRB2-CTNNA1
Immune System
Metabolism
7
IL1B-A2M, HSP90AB1-GNAI2, GSTP1-TRAF2,
RXRA-ZBTB16, RXRA-RELA, CYCS-TRAF6,
GSTP1-MAPK8
Gene
Immune System
7
Expression
RXRA-ZBTB16, RXRA-RELA, MAP3K7-SMAD3,
CAMK2G-SMAD3, HSPB1-MAPKAPK3,
EGFR-HSPA1B, CAMK2A-SMAD2
Disease
Cell Cycle
7
GSK3B-CCND1, TP53-FOXO3, BIRC5-CASP9,
CCNB1-FOXO1, TP53-CREB1, TP53-BCR,
CCNE1-GSK3B
Immune System
Cell-Cell
7
communication
MAP3K3-FLNA, ACTN1-CAMK2A, CAMK2G-FLNA,
JUP-ERBB2, PTK2-PIAS1, HSP90AB1-FLNA,
TRAF2-FLNA
Disease
Hemostasis
7
CALR-F8, KLK3-FN1, MMP2-A2M, TP53-FOXO3,
TP53-CREB1, TP53-BCR, KLK3-A2M
Gene
Cell Cycle
7
Expression
HSPB1-TP53, CDK2-SMAD3, TP53-HSPA1B,
TP53-SMAD2, CDK4-SMAD3, CDK6-AR,
BUB1-EIF4EBP1
Hemostasis
Signal
7
Transduction
DNA
Signal
Replication
Transduction
Apoptosis
Cell-Cell
TGFB2-BMP2, TP53-CREB1, TP53-BCR, TP53-STK4
6
Disease
CDK2-SMAD3, BIRC5-CASP9, PTK2-CCNA1,
CCNB1-FOXO1, BUB1-EIF4EBP1, BUB1-APC
6
communication
Apoptosis
CDK2-SMAD3, TP53-FOXO3, TP53-SMAD2,
FASLG-PIK3R1, FASLG-FYN, APPL1-PIK3CA,
JUP-APC, APC-CTNNA1, TRAF2-FLNA
6
FASLG-PIK3R1, FASLG-FYN, APPL1-PIK3CA,
TRAF2-ERN1, FAS-PRKCA, MAPK3-DAPK1
Apoptosis
Metabolism
6
FASLG-PIK3R1, GSTP1-TRAF2, APPL1-PIK3CA,
GSTP1-MAPK8, FAS-PRKCA, FAS-RAP1A
Gene
Hemostasis
5
Expression
Immune System
TP53-SMAD2, HDAC2-PPARD
Neuronal
5
System
Hemostasis
HSPB1-TP53, CDK2-SMAD3, TP53-HSPA1B,
Neuronal
NEFL-APP, PARK2-GRIN2B
5
System
Gene
Signal
Expression
Transduction
Cell-Cell
Signal
communication
Transduction
DNA
Apoptosis
HSP90AB1-GNAI2, LCK-DLG1, PARK2-DLG1,
LCK-DLG1, ACTN1-CAMK2A, CAMK2G-FLNA,
TP53-CREB1, NEFL-APP
5
HNF4A-CTNNB1, RXRA-RELA, HSPB1-MAPKAPK3,
EGFR-HSPA1B, HDAC2-PPARD
4
JUP-ERBB2, JUP-APC, ARRB2-CTNNA1, APC-CTNNA1
4
Replication
BIRC5-CASP9, PTK2-CCNA1, MAPK3-DAPK1,
BUB1-APC
Signal
Neuronal
Transduction
System
4
LCK-DLG1, NEFL-APP, CAMK2G-SMAD3,
CAMK2A-SMAD2
Apoptosis
Gene
4
Expression
Metabolism
Signal
MAPK3-DAPK1
3
Transduction
RXRA-RELA, CYCS-TRAF6, GSTP1-MAPK8
Apoptosis
Circadian Clock
3
DNA
Developmental
3
Replication
Biology
Developmental
Neuronal
Biology
System
Disease
Signal
Developmental
3
Disease
3
KLK3-FN1, MMP2-A2M, KLK3-A2M
2
LCK-DLG1, CBL-MET
2
Replication
BIRC5-CASP9, CCNB1-FOXO1
Gene
Developmental
Expression
Biology
Cell-Cell
Neuronal
communication
System
Disease
Gene
2
HNF4A-CTNNB1, EGFR-HSPA1B
2
ACTN1-CAMK2A, CAMK2G-FLNA
2
Expression
KLK3-AR, EGFR-HSPA1B
Neuronal
Gene
System
Expression
DNA
Gene
Replication
Expression
Disease
Metabolism
2
Cell-Cell
Cell Cycle
2
2
CAMK2G-SMAD3, CAMK2A-SMAD2
2
CDK2-SMAD3, BUB1-EIF4EBP1
communication
Developmental
MMP2-A2M, KLK3-A2M
PTK2-CCNA1, CDK6-CTNNB1
Metabolism
2
Biology
HSP90AB1-GNAI2, INHBB-ACVR1C
Cell-Cell
Developmental
communication
Biology
DNA
Immune System
Replication
HSP90AB1-GNAI2, CAMK2G-SMAD3,
CAMK2A-SMAD2
Biology
DNA
APC-CSNK1E, BID-CSNK1E, OCLN-CSNK1E
CDK2-SMAD3, PTK2-CCNA1, CCNB1-FOXO1
Transduction
Disease
APPL1-HDAC1, HNF4A-CTNNB1, FAS-PRKCA,
2
JUP-ERBB2, HSP90AB1-FLNA
2
BIRC5-CASP9, CCNB1-FOXO1
Signal
Circadian Clock
1
Transduction
APC-CSNK1E
DNA Repair
Apoptosis
1
RAD51-CASP3
Immune System
Disease
1
TRAF2-ERN1
Metabolism of
Hemostasis
1
proteins
Cell-Cell
CALR-F8
Disease
1
communication
JUP-ERBB2
Cellular
Gene
responses to
Expression
1
stress
DNA Repair
EPAS1-SMAD3
Signal
1
Transduction
Hemostasis
DNA
RAD51-CASP3
1
Replication
Apoptosis
Neuronal
PTK2-CCNA1
1
System
Extracellular
Metabolism
FAS-PRKCA
1
matrix
organization
MMP2-A2M
Extracellular
Signal
matrix
Transduction
1
organization
MMP2-A2M
Hemostasis
Cell Cycle
1
Extracellular
Apoptosis
1
PTK2-CCNA1
matrix
organization
MMP7-FASLG
Cellular
Signal
responses to
Transduction
1
stress
EPAS1-SMAD3
Cell-Cell
DNA
communication
Replication
Metabolism
Cell-Cell
communication
1
PTK2-CCNA1
1
GSTP1-MAPK8
Extracellular
Hemostasis
1
matrix
organization
Hemostasis
MMP2-A2M
Cell-Cell
1
communication
DNA
Metabolism of
Replication
proteins
Gene
Cell-Cell
Expression
communication
Disease
Neuronal
ARRB2-CTNNA1
1
BUB1-EIF4EBP1
1
HNF4A-CTNNB1
1
System
Cellular
Developmental
responses to
Biology
LCK-DLG1
1
stress
Cell Cycle
EPAS1-SMAD3
Neuronal
1
System
Cell Cycle
Metabolism of
proteins
TP53-CREB1
1
BUB1-EIF4EBP1