90 cross-talk PPI-pathway list.
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90 cross-talk PPIs, which link at least two pathways, were listed. 90 cross-talk PPIs No. of pathway Gene A Pathway(s) of Gene A Pathway(s) of Gene B Gene B linkages Cell Cycle, Signal Transduction, Apoptosis Disease, Gene Expression, Immune MAPK3 DAPK1 9 System, Developmental Biology, DNA Replication, Hemostasis Apoptosis FAS PRKCA 8 Signal Transduction, Disease, Gene Expression, Metabolism, Neuronal System, Immune System, Hemostasis Apoptosis Signal Transduction, Disease, Metabolism, Cell-Cell FASLG PIK3R1 7 communication, Immune System, Hemostasis Apoptosis Signal Transduction, Disease, Cell-Cell communication, Immune FASLG FYN 7 System, Developmental Biology, Hemostasis Signal Transduction, Cell-Cell PTK2 CCNA1 7 Cell Cycle, DNA Replication communication, Developmental Biology, Apoptosis, Hemostasis Apoptosis Signal Transduction, Disease, Metabolism, Cell-Cell APPL1 PIK3CA 7 communication, Immune System, Hemostasis Cell Cycle, Hemostasis TP53 CREB1 7 Signal Transduction, Disease, Neuronal System, Immune System, Developmental Biology HSP90AB1 LCK CDK2 GNAI2 DLG1 SMAD3 Immune System, Developmental Signal Transduction, Metabolism, Biology Neuronal System, Hemostasis Signal Transduction, Disease, Neuronal System, Developmental Immune System, Hemostasis Biology Cell Cycle, DNA Replication, Signal Transduction, Gene 6 6 6 TP53 FOXO3 Hemostasis Expression, Developmental Biology Cell Cycle, Hemostasis Signal Transduction, Disease, 6 Immune System, Developmental Biology Cell Cycle, DNA Replication BIRC5 CASP9 Signal Transduction, Disease, 6 Immune System, Apoptosis Signal Transduction, Cell-Cell PTK2 PIAS1 6 Immune System communication, Developmental Biology, Apoptosis, Hemostasis Cell Cycle, DNA Replication CCNB1 FOXO1 6 Signal Transduction, Disease, Immune System, Developmental Biology Signal Transduction, Disease, GSK3B CCND1 5 Cell Cycle Immune System, Developmental Biology Apoptosis APPL1 HDAC1 Cell Cycle, Signal Transduction, 5 Gene Expression, Hemostasis MMP2 JUP A2M ERBB2 Disease, Extracellular matrix Signal Transduction, Metabolism, organization Hemostasis Cell-Cell communication Signal Transduction, Disease, 5 5 Immune System, Developmental Biology Gene Expression HNF4A CTNNB1 5 Signal Transduction, Cell-Cell communication, Developmental Biology, Apoptosis Cell Cycle, Hemostasis TP53 SMAD2 Signal Transduction, Gene 5 Expression, Developmental Biology Gene Expression, Metabolism, RXRA RELA Signal Transduction, Immune System 5 Developmental Biology Cell Cycle CDK6 CTNNB1 5 Signal Transduction, Cell-Cell communication, Developmental Biology, Apoptosis Neuronal System, Immune System CAMK2G SMAD3 Signal Transduction, Gene 5 Expression, Developmental Biology Signal Transduction, Disease, EGFR HSPA1B 5 Gene Expression Immune System, Developmental Biology Immune System, Apoptosis FADD RHOA Signal Transduction, Developmental 5 Biology, Hemostasis Metabolism GSTP1 MAPK8 5 Signal Transduction, Cell-Cell communication, Immune System, Apoptosis Cell Cycle, DNA Replication BUB1 EIF4EBP1 Signal Transduction, Gene 5 Expression, Metabolism of proteins Apoptosis FAS RAP1A Signal Transduction, Metabolism, 5 Immune System, Hemostasis Cell Cycle CCNE1 GSK3B 5 Signal Transduction, Disease, Immune System, Developmental Biology Neuronal System, Immune System CAMK2A SMAD2 Signal Transduction, Gene 5 Expression, Developmental Biology Apoptosis BID RHOA Signal Transduction, Developmental 4 Biology, Hemostasis Cellular responses to stress EPAS1 SMAD3 Signal Transduction, Gene 4 Expression, Developmental Biology Immune System IL1B A2M Signal Transduction, Metabolism, 4 Hemostasis Apoptosis CASP6 APP Signal Transduction, Immune 4 System, Hemostasis Disease, Metabolism of proteins, CALR F8 Hemostasis 4 Immune System Signal Transduction, Disease, CBL MET Developmental Biology 4 Immune System ACTN1 CAMK2A 4 RXRA ZBTB16 4 Cell-Cell communication, Hemostasis Neuronal System, Immune System Gene Expression, Metabolism, Immune System Developmental Biology CAMK2G FLNA 4 Neuronal System, Immune System Cell-Cell communication, Hemostasis HSP90AB1 FLNA 4 Immune System, Developmental Cell-Cell communication, Hemostasis Biology TP53 BCR 4 MAP3K7 SMAD3 4 Cell Cycle, Hemostasis Signal Transduction, Disease Immune System Signal Transduction, Gene Expression, Developmental Biology APC CSNK1E 4 CDK4 SMAD3 4 Signal Transduction, Apoptosis Cell Cycle, Circadian Clock Cell Cycle Signal Transduction, Gene Expression, Developmental Biology Neuronal System NEFL APP Signal Transduction, Immune 4 System, Hemostasis Signal Transduction, Hemostasis ARRB2 CTNNA1 Cell-Cell communication, 4 Developmental Biology Disease KLK3 A2M Signal Transduction, Metabolism, 4 Hemostasis Apoptosis FAS RHOA Signal Transduction, Developmental 4 Biology, Hemostasis Signal Transduction, Apoptosis APC CTNNA1 Cell-Cell communication, 4 Developmental Biology CYCS TRAF6 4 Metabolism, Apoptosis Signal Transduction, Immune System TRAF2 FLNA 4 Immune System, Apoptosis Cell-Cell communication, Hemostasis BUB1 APC 4 Cell Cycle, DNA Replication Signal Transduction, Apoptosis HSPB1 TP53 3 Gene Expression Cell Cycle, Hemostasis MAP3K3 FLNA 3 Immune System Cell-Cell communication, Hemostasis GSTP1 TRAF2 3 Metabolism Immune System, Apoptosis CASP3 MET 3 Signal Transduction, Apoptosis Developmental Biology ARRB2 PPM1B 3 Signal Transduction, Hemostasis Immune System RALBP1 TRAF2 3 Signal Transduction Immune System, Apoptosis Immune System Neuronal System, Developmental PARK2 DLG1 3 Biology KLK3 FN1 3 Disease Signal Transduction, Hemostasis TP53 CSNK2A1 3 Cell Cycle, Hemostasis Developmental Biology TP53 BAX 3 Cell Cycle, Hemostasis Apoptosis FASLG FN1 3 Apoptosis Signal Transduction, Hemostasis TP53 PIAS1 3 Cell Cycle, Hemostasis Immune System WEE1 FBXW11 3 Cell Cycle, Hemostasis Immune System TP53 HSPA1B 3 Cell Cycle, Hemostasis Gene Expression TNFRSF1A IKBKB 3 Apoptosis Signal Transduction, Immune System JUP APC 3 Cell-Cell communication Signal Transduction, Apoptosis APC CSNK2A1 3 Signal Transduction, Apoptosis Developmental Biology TRAF2 ERN1 3 Immune System, Apoptosis Disease HSPB1 MAPKAPK3 3 Gene Expression Signal Transduction, Immune System MAP3K14 CASP3 3 Immune System Signal Transduction, Apoptosis ARRB2 MAP3K1 3 Signal Transduction, Hemostasis Immune System HDAC2 PPARD 3 Signal Transduction, Hemostasis Gene Expression TP53 STK4 3 Cell Cycle, Hemostasis Signal Transduction BID CSNK1E 3 Apoptosis Cell Cycle, Circadian Clock OCLN CSNK1E 3 Apoptosis Cell Cycle, Circadian Clock RAD51 CASP3 3 DNA Repair Signal Transduction, Apoptosis FADD EZR 3 Immune System, Apoptosis Developmental Biology APC SIAH1 3 Signal Transduction, Apoptosis Developmental Biology MAP3K3 MAP2K5 2 Immune System Signal Transduction KLK3 AR 2 Disease Gene Expression IL6 HRH1 2 Immune System Signal Transduction MAP3K7 RUVBL1 2 Immune System Cell Cycle INHBB ACVR1C 2 Metabolism Developmental Biology MMP7 FASLG 2 Extracellular matrix organization Apoptosis TGFB2 BMP2 2 Hemostasis Signal Transduction CDK6 AR 2 Cell Cycle Gene Expression RALBP1 IKBKG 2 Signal Transduction Immune System PARK2 GRIN2B 2 Immune System Neuronal System
