Instructor:
Assist. Prof. Dr. Alper SISMAN
http://mimoza.marmara.edu.tr/~alper.sisman/courses.html
Room#: EA103
e-mail: alper.sisman@marmara.edu.tr
Couse schedule: Friday 14-17. Office Hours: Office Hours: TBA/ Students can arrange a meeting with the instructor anytime, if they inform
the instructor via e-mail.
Course Overview
This course will provide an overview of instrumentation systems used in clinical medicine and biomedical research. We will review some
signals/systems, circuit theory, and their application to bioinstrumentation. Systems for measuring biologic signals will be discussed
including biopotentials, stress and strain, pressure, temperature, and optical properties. Electrical hazards, safety, measuring instruments
and techniques will be discussed. There will be applications to engineering design including transducer systems and sensing and driving
circuits.
Course Goals
After successfully completing the course, you will have a good understanding of the following topics and their applications:
Textbook
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Biosignals and their acquisition
Circuits and bioinstrumentation applications
Origin of biopotentials
Instrumentation for cardiovascular measurements
Biochemical sensors
Safety in bioinstrumentation and electrical hazards
Webster JG. Medical Instrumentation: Application and Design, 4th ed. 2010 John Wiley & Sons: New York.
Teaching Methods
Theoretical lectures.
Evaluation Tools
Final Exam 45%
Midterm Exam 45%
Pop Quizzes %10
Homeworks %0 ……. Homeworks are mandatory: the midterm and Quiz grades will be halved, if 80% of home works are not
delivered on time.
Exam Rules: All exams and quizzes are open book and notes. All students must show their own efforts, cheating is strictly forbidden. All
the answers must be clearly explained, clear explanation of the answer is the responsibility of the student. The instructor will help to
solve the questions in QUIZZES ONLY. In QUIZZES ONLY, students can ask reasonable questions to the instructor. The students
can discuss with each other about the quiz questions.
Weekly Plan
1
Intro to course & bioinstrumentation. Instrumentation systems. Short signal Processing review Chap. 1 (Sec. 1.2, 1.3, 1.5, 1.8-1.10)
2
Operational modes, measurement characteristics. Circuit analysis review. Chap. 1 (Sec. 1.2, 1.3, 1.5, 1.8-1.10)
3
4
Switches, relays and potentiometers. Transducers and sensors. Chap. 2 (Sec. 2.1-2.9)
Circuit analysis and design. Power supplies. Amplifiers and op amps. Active filtering. Impedance matching. Timing and digital circuits.
Reading: Chap. 3 (Sec. 3.1-3.5, 3.10-3.12, 3.14, 3.16)
5
Origin of biopotentials. Chap. 4 (Sec. 4.1-4.8)
6
Biopotential
electrodes.
Chap.
(Sec.special
5.1-5.11)
The relation
between
free
var., 5pivot,
solution concepts
and vector
spaces.
properties
of matrix
inverse
operator.
Factorization
using gauss
elimination
and L-U factorization.
7
Electrocardiogram, common-mode suppression, active shielding. Chap. 6 (Sec. 6.1-6.6)
8
Midterm
9
Instrumentation for cardiovascular measurements Chapters 7 & 8 (Sec. 7.1-7.4, 7.14-7.14, 8.1-8.4).
10
Bio Chemical sensors. Chap. 10 (Sec. 10.1-10.6)
11
Safety in bioinstrumentation, electrical hazards Chap. 14 (Sec. 14.1-14.9).
12
Bioinstrument applications – MEMS structures/front-end electronics for Intravascular imaging
13
Bioinstrument applications – MEMS structures for protein purification
14
Bioinstrument
applications
MEMS structures for drug delivery systems
stability conditions
and their– solutions.
15
Final Exam