OIE Collaborating Centre Reports
Activities in 2013
Title of Collaborating Centre:
Diagnosis and Control of Animal
Diseases and Related Veterinary
Product Assessment in Asia
Address of Collaborating Centre:
(1): National Institute of Animal Health
3-1-5 Kannondai, Tsukuba, Ibaraki 305-0856, JAPAN
(2): National Veterinary Assay Laboratory
1-15-1 Tokura, Kokubunji, Tokyo 185-8511, JAPAN
Tel.:
(1): National Institute of Animal Health
+81-42-321-1441
(2): National Veterinary Assay Laboratory
+81-42-321-1862
Fax:
(1): National Institute of Animal Health
+81-42-325-5122
(2): National Veterinary Assay Laboratory
+81-42-321-1769
e-mail address:
(1): National Institute of Animal Health
skenichi@affrc.go.jp
(2): National Veterinary Assay Laboratory
iwamoto@nval.maff.go.jp
website:
(1): National Institute of Animal Health
http://niah.naro.affrc.go.jp/index.html
(2): National Veterinary Assay Laboratory
http://www.maff.go.jp/nval/english/
Name of Director of Institute (1): National Institute of Animal Health
(Responsible Official): Dr Tomoyuki Tsuda, Director General
(2): National Veterinary Assay Laboratory
Dr Taketsugu Ito, Director General
Name (including Title and
Position) of Head of the
Collaborating Centre (formally
OIE Contact Point):
Dr Kenichi Sakamoto
Director
Exotic Disease Research Division
National Institute of Animal Health
Name (including Title and (1): National Institute of Animal Health
Position) of writer of this report Dr Kazuhiro Yoshihara
Head of Planning and Promotion Section
(if different from above)
(2): National Veterinary Assay Laboratory
Dr Shoko Iwamoto
Technical and Guidance Section Leader
Annual reports of OIE Reference Centres, 2013
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Diagnosis and Control of Animal Diseases and Related Veterinary Product Assessment in Asia
Summary of activities specifically related to the mandate of
OIE Collaborating Centres
ToR:
To provide services to the OIE, in particular within the region, in the designated
specialty, in support of the implementation of OIE policies and, where required, seek for
collaboration with OIE Reference Laboratories
ToR:
To identify and maintain existing expertise, in particular within its region
1.
Activities as a centre of research, expertise, standardisation and dissemination of
techniques within the remit of the mandate given by the OIE
Disease control
Epidemiology, surveillance, risk assessment, modelling
Training, capacity building
Zoonoses
Wildlife
Avian diseases
Aquatic animal diseases
Animal welfare
Diagnosis, biotechnology and laboratory
Veterinary medicinal products
Vaccines
Food safety
Feed safety
Other (Name the category: Organisation of Scientific Meeting, OIE Meeting )
Disease control
2
Title of activity
Scope
Presentation in Symposium
of Diagnostic Technique
and Epidemic Control
Strategies on Swine Viral
Disease at Animal Health
Research Institute in
Taiwan, R.O.C.
Dr H. Tsunemitsu, Dr T. Kokuho and Dr M. Takagi were invited as speakers
and made presentations entitled Laboratory and research support on the
eradication of classical swine fever in Japan (Dr Takagi) and Molecular
epidemiology and diagnosis of porcine reproductive and respiratory
syndrome in Japan (Dr Takagi), Molecular epidemiology of porcine viral
diarrhea: porcine epidemic diarrhea in Asia and the U.S. (Dr Tsunemitsu),
Epidemic situation, and control policy of swine viral diseases in Japan (Dr
Kokuho).
Attendance at the 8th
SEACFMD Laboratory
Network Meeting on Nov
12th and 13th in Thailand
Dr K. Sakamoto attended the 8th SEACFMD Laboratory Network Meeting as
a FMD expert.
Dispatch to Myanmar as
an expert of FMD to
exchange opinions about
the technical cooperation
for FMD control
Dr T. Kanno joined the investigating group of the Ministry of Agriculture,
Forestry and Fisheries in Japan to exchange opinions about the technical
cooperation for FMD control in Myanmar.
Discussion with National
Institute of Animal Health
in Thailand about PRRS
and CSF
Dr T. Kawashima and Dr T. Takagi visited NIAH in Thailand to discuss a
study on PRRS and CSF.
Presentation in First
International Workshop on
Dr D. Takamatsu was invited as a speaker and made a presentation entitled
Diversity and Universality of Streptococcus suis cps Gene Clusters.
Annual reports of OIE Reference Centres, 2013
Diagnosis and Control of Animal Diseases and Related Veterinary Product Assessment in Asia
Streptococcus suis,
Canada-China
Collaboration, in China.
Epidemiology, surveillance, risk assessment, modelling
Title of activity
Scope
Presentation at
International Symposium
of Korean Society of
Veterinary Science and at
Internal workshop of
Veterinary Epidemiology
Dr T. Tsutsui was invited as a speaker and made presentations entitled
Epidemiology of foot-and-mouth disease in Japan at the symposium and the
workshop in Korea.
The review at the middle of
the term of JICA Project on
Capacity Development of
the Animal Health
Laboratory in Indonesia
Dr T. Yamamoto reviewed the field of epidemiology of the JICA project in
Indonesia.
Investigation into the titer
of antibody to FMD virus in
Laos
Dr K. Sakamoto, Dr K. Fukai and Dr K. Morioka carried out a field
surveillance for the titer of antibody to FMD virus from cattle inoculated
FMD vaccine in Laos.
Training, capacity building
Title of activity
Scope
Dispatch as an expert of
FMD to Myanmar to
conduct Identification
Survey for The Project for
Improvement of FMD
Control in Myanmar
Dr K. Sakamoto joined the investigating group to conduct preliminary
survey for JICA's new project aiming at vaccine production in Myanmar as
an expert of FMD.
JICA Project on Capacity
Development of Animal
Health Laboratory in
Indonesia
Dr T. Shibahara was sent to Balai Veteriner Subang in Indonesia as a JICA
expert of pathology for two months to contribute toward JICA Project on
Capacity Development of Animal Health Laboratory in Indonesia
Zoonoses
Title of activity
Scope
Monitoring of
antimicrobial resistant
bacteria from
environmental origin
More than 500 Enterobacteriaceae were isolated from environmental water
samples collected in India and Sri Lanka in 2013 and investigated their
antimicrobial susceptibilities to chech the environmental contamination by
resistant bacteria. (Dr M. Akiba and Dr Guruge Keerthi Siri)
Veterinary medicinal products, vaccines
Title of activity
Scope
Quality Control activities
for veterinary medicinal
products and vaccines
A total of 5 veterinary medicinal products were tested on request from
manufacturing authorization holder and 391 biologics were received the
national assay in 2013.
Approval Activities for
veterinary medicinal
products and vaccines
A total of 38 antibiotics (including 4 in vitro diagnostics for antibiotics), 31
biologics (including 4 in vitro diagnostics for biologics) and 40 other VMPs
(including 1 in vitro diagnostic) were approved in 2013.
Annual reports of OIE Reference Centres, 2013
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Diagnosis and Control of Animal Diseases and Related Veterinary Product Assessment in Asia
Other: Organisation of Scientific Meeting
Title of activity
Scope
Holding the Second Joint
Meeting of NIAH Japan
and NIAH Thailand
Based of the MOU on strengthening research cooperation in the fields of
mutual interest on veterinary science with National Institute of Animal
Health in Thailand, the scientific meeting was held in NIAH, Tsukuba, Japan
to exchange information and talk about possibility of research cooperation.
The third meeting will be held in Thailand in 2014.
Other: OIE Meeting
4
Title of activity
Scope
Attendance at Terrestrial
Animal Health Standards
Commission (the Code
Commission) on Sep 17-26
in France
Dr T. Tustsui who is a member of the code commission was invited the Code
Commission by OIE.
Attendance at Technical
meeting of OIE experts on
Schumallengerg virus on
May 7-8 in France.
Dr Tsutsui was invited to Technical meeting of OIE experts on
Schumallengerg virus.
Attendance at FMD
Scientific Meeting for East
Asia under OIE/JTF Project
for FMD Control in Asia on
Oct 8th in Mongolia
Dr K. Sakamoto was invited to FMD Scientific Meeting for East Asia under
OIE/JTF Project for FMD Control in Asia as a chairman.
Attendance at 2nd
National Contact Person
Workshop and 2nd
Coordination Committee
Meetin under OIE/JTF
Project on FMD Control in
Asia on Oct 6th and 7th in
Mongolia
Dr K. Sakamoto was invited to 2nd National Contact Person Workshop and
2nd Coordination Committee Meetin under OIE/JTF Project on FMD Control
in Asia by OIE.
Attendance at the Meeting
of the OIE Terrestrial
Animal Health Standards
Commission as a member
of the code commission on
Feb 19-28 in Paris
Dr T. Tsutsui who is a member of the code commission attended the
Meeting of the OIE Terrestrial Animal Health Standards Commission as a
member of the code commission.
Attendance at the SouthEast Asian countries and
China discuss foot and
mouth disease control on
Mar. 19 in Singapore
Dr K. Sakamoto was invited the OIE Meeting, South-East Asian countries
and China discuss foot and mouth disease control by OIE.
Attendance at 28th
Conference of the OIE
Regional Commission for
Asia on Nov. 18-22 in
Philippines
Dr T. Tsutsui was invited 28th Conference of the OIE Regional Commission
for Asia and presented at Regional Seminar for OIE Delegates on Activities
of Specialist Commissions entiteld "Principle and Procedures of OIE standard
Setting" as a member of the code commission.
Dr M. Yamada and Dr K. Fukai were invited for speakers to the meeting by
OIE. Titles: Characters of FMD DIVA tests and Verification of Efficacy of
Expired FMD O Type Vaccines (Dr Yamada), Experimental infections in
animals using a foot-and-mouth disease virus isolated from the 2010
epidemic in Japan (Dr Fukai)
Annual reports of OIE Reference Centres, 2013
Diagnosis and Control of Animal Diseases and Related Veterinary Product Assessment in Asia
ToR:
To propose or develop methods and procedures that facilitate harmonisation of
international standards and guidelines applicable to the designated specialty
2.
Proposal or development of any procedure that will facilitate harmonisation of
international regulations applicable to the surveillance and control of animal diseases,
food safety or animal welfare
Proposal title
Scope/Content
Applicable area
Development of
the VICH
guidelines (GLs)
concerning to
studies to
evaluate the
quality of
veterinary drugs.
-To develop the new VICH GL
51(statistical evaluation of stability
data)
Surveillance and control of animal diseases
Development of
the VICH
guidelines (GLs)
concerning to
pharmacovigilanc
e of
veterinary drugs.
Development of
the VICH
guidelines (GLs)
concerning to
veterinary
biological quality
monitoring.
Development of
VICH
harmonisation
criteria to waive
target animal
batch safety
testing for
vaccines for
veterinary use.
Development or
revision of the
VICH guidelines
(GLs) concerning
to studies to
evaluate the
metabolism and
residue kinetics
of veterinary
drugs in foodproducing
animals.
Development or
revision of the
VICH guidelines
(GLs) concerning
to studies to
evaluate the
safety of residues
of veterinary
-To develop the new VICH GL 35
(electronic standards for transfer of
data )
Surveillance and control of animal diseases
Food safety
Animal welfare
Food safety
Animal welfare
-To develop the new VICH GL 34
(test for the detection of
Mycoplasma contamination )
-To develop the new VICH GL (test
on the presence of extraneous
viruses in veterinary viral vaccines
)
-To develop the VICH GL50 (for
inactivated vaccines)
-To develop the new VICH GL (for
live vaccines)
Surveillance and control of animal diseases
-To revise the VICH GL48 (marker
residue depletion studies to
establish product withdrawal
periods)
-To develop the new VICH GL
(marker residue depletion studies to
establish product withdrawal
periods in aquatic species)
-To develop the new VICH GL
(residue studies in honey)
Surveillance and control of animal diseases
-To revise the VICH GL 23R
(genotoxicity testing)
-To develop the new VICH GL (use
of the acute reference dose for
veterinary drugs)
Surveillance and control of animal diseases
Annual reports of OIE Reference Centres, 2013
Food safety
Animal welfare
Surveillance and control of animal diseases
Food safety
Animal welfare
Food safety
Animal welfare
Food safety
Animal welfare
5
Diagnosis and Control of Animal Diseases and Related Veterinary Product Assessment in Asia
Proposal title
drugs in human
food.
Development of
the VICH
guidelines (GLs)
concerning to
bioequivalance of
veterinary drugs.
Development of
the VICH
guidelines (GLs)
concerning to
electronic
exchange of
documents.
Scope/Content
Applicable area
-To develop the new VICH GL 52
(blood level bioequivalence study )
Surveillance and control of animal diseases
Food safety
Animal welfare
-To develop the new VICH GL 53
(file format requirements )
Surveillance and control of animal diseases
Food safety
Animal welfare
ToR:
To establish and maintain a network with other OIE Collaborating Centres designated
for the same specialty, and should the need arise, with Collaborating Centres in other
disciplines
ToR:
To carry out and/or coordinate scientific and technical studies in collaboration with
other centres, laboratories or organisations
3.
Did your Collaborating Centre maintain a network with other OIE Collaborating Centres
(CC), Reference Laboratories (RL), or organisations designated for the same specialty, to
coordinate scientific and technical studies?
Yes
Name of OIE CC/RL/other
organisation(s)
Animal and Plant
Quarantine Agency
6
No
Location
Korea
National Institute of Animal
Health
Thailand
Department of Livestock
Development
Thaiand
Mahidol University
Thailand
ANSES, FDA-CVM
EU, USA,
Japan
Region of
networking Centre
Africa
Americas
Asia and Pacific
Europe
Middle East
Africa
Americas
Asia and Pacific
Europe
Middle East
Africa
Americas
Asia and Pacific
Europe
Middle East
Africa
Americas
Asia and Pacific
Europe
Middle East
Africa
Americas
Asia and Pacific
Europe
Middle East
Purpose
General MOU on promoting research
cooperation in the fields of mutual
interest such as surveillance, diagnosis
and control of major animal diseases
General MOU on strengthening
research cooperation in the fields of
mutual interest on veterinary science
MOU on a collaboration project entitled
“Epidemiological Research
Collaboration on Avian Influenza and
Zoonotic Diseases in Thailand and
Neighbouring Countries”
MOU on a collaboration project entitled
“Epidemiological and pathogenicity
researches on avian influenza, arbovirus
infection and porcine respiratory
diseases etc”
To prepare for the VICH Outreach
Forum that is held every 9 month back
to back with the VICH Steering
Committee (SC). The VICH Outreach
Annual reports of OIE Reference Centres, 2013
Diagnosis and Control of Animal Diseases and Related Veterinary Product Assessment in Asia
Name of OIE CC/RL/other
organisation(s)
Asian veterinary medicinal
products regulatory
authorities
4.
Location
China,
Hong
Kong,
Indonesia,
Korea
,Philippine
s, Taiwan,
Thailand
and Japan
Region of
networking Centre
Purpose
Subgroup consists of VICH-SC member
and OIE Collaborating Centres work
together to establish a program and to
nominate speakers and a chair of the
forum meeting. The Training Strategy
ad hoc working group also consists of
VICH-SC member and OIE Collaborating
Centres work to design overall training
strategy for VMP authority in member
countries.
In order to reduce information gap
among the members in Asian region, a
mail news called "AVAIL*news" is sent
on irregular basis (7 issues in 2013) to
Asian VMP regulatory authorities
(Codex Committee-Asia members and
VICH Outreach Forum members of
interest).
*AVAIL: Asian VMP Authority
Information Link is an informal
communication among Asian
Veterinary Medicinal ProductAuthorities
Africa
Americas
Asia and Pacific
Europe
Middle East
Did your Collaborating Centre maintain a network with other OIE Collaborating Centres,
Reference laboratories, or organisations in other disciplines, to coordinate scientific and
technical studies?
Yes
No
ToR:
To place expert consultants at the disposal of the OIE.
5.
Did your Collaborating Centre place expert consultants at the disposal of the OIE?
Yes
Name of expert
No
Kind of consultancy
Subject
Dr Toshiyuki Tsutsui
The OIE Code Committee
A member
Dr Takashi Yokoyama
OIE Reference Laboratory
BSE
Dr Shunji Yamada
OIE Reference Laboratory
Classical Swine Fever
Dr Makoto Yamakawa
OIE Reference Laboratory
Equine Infectious Anemia
Dr Takehiko Saito
OIE Reference Laboratory
Swine Influenza
Dr Kazuhiro Yoshihara
OIE National Focal Point
Veterinary Laboratories
NIAH
NVAL
Dr Ken Noda
Consultation on VMP
regulatory affairs in Japan, for
the regulatory authorities in
Annual reports of OIE Reference Centres, 2013


Approval status of an antimicrobial
product and a MRL setting in Japan.
Approval status of antimicrobials for
7
Diagnosis and Control of Animal Diseases and Related Veterinary Product Assessment in Asia
Name of expert
Kind of consultancy
Subject
Asia-Pacific region.





Dr Michiko KAWANISHI
Speaker
layer chicken and tentative MRL for the
products not approved in Japan.
Corresponding regulatory authority for
veterinary Products by categories.
Selection methodology for the serum
type of FMD vaccine and information on
the import-acceptance testing in Japan.
Request for the recommendation of the
speaker for an international workshop
on off label use of VMP, and a VMP for
minor use and minor species.
Categorisation for prescription and nonprescription VMP in Japan.
Approval status of VMPs for milking
cows in Japan.
OIE GLOBAL CONFERENCE ON THE
RESPONSIBLE AND PRUDENT USE OF
ANTIMICROBIAL AGENTS FOR ANIMALS
ToR:
To provide, within the designated specialty, scientific and technical training to personnel
from OIE Member Countries
6.
Did your Collaborating Centre provide scientific and technical training, within the remit of
the mandate given by the OIE, to personnel from OIE Member Countries?
Yes
No
If the answer is yes, please provide the total number of trained persons for each of the following
categories:
8
a)
Technical visits: ................................................................ 2
b)
Seminars: .........................................................................
c)
Hands-on training courses: .............................................. 2
d)
Internships (>1 month): ...................................................
Annual reports of OIE Reference Centres, 2013
Diagnosis and Control of Animal Diseases and Related Veterinary Product Assessment in Asia
Type of technical
training provided
(a, b, c or d)
Country of origin of the
expert(s) provided with
training
No. participants from
the corresponding
country
Indonesia
2
Research on diagnostic methods for
parasitic diseases in domestic
animals
Afghanistan
1
Mongolia
2
Research on pathological diagnosis
for porcine respiratory diseases
Malaysia
1
Research on diagnosis for digestive
viral diseases
Malaysia
1
Research on diagnosis for pig and
avian respiratory viral diseases
Indonesia
1
Singapore
Indonesia
Vietnam
Myanmar
Thailand
1
1
1
1
1
Content
a
NIAH has dispatched 2 research
staff as JICA experts (Veterinary
Public Health and Pathology) to
JICA project entitled "Project on
Capacity Development of Animal
Health Laboratory" at Disease
Investigation Center Subang,
Indonesia.
c
JICA Group Training Course for 7
months:
c
Regional Short-term Training on
Veterinary Vaccine Assessment
Tokyo, Japan, 7-11 October 2013
ToR:
To organise and participate in scientific meetings and other activities on behalf of the
OIE
7.
Did your Collaborating Centre organise or participate in the organisation of scientific
meetings on behalf of the OIE?
Yes
No
ToR:
To collect, process, analyse, publish and disseminate data and information relevant to
the designated specialty
8.
Publication and dissemination of any information within the remit of the mandate given by
the OIE that may be useful to Member Countries of the OIE
(Indicate in the appropriate box the number by category)
a)
Articles published in peer-reviewed journals: ................. 32
NIAH
Articles of BSE and influenza are in each OIE Reference Laboratory Reports.
Tamamura Y., Tanaka K., Akiba M., Kanno T., Hatama S., Ishihara R. & Uchida I. (2013). Complete nucleotide
sequences of virulence-resistance plasmids carried by emerging multidrug-resistant Salmonella enterica
serovar Typhimurium isolated from cattle in Hokkaido, Japan. PLoS One. 8(10), e77644.
Nagano-Kobayashi S., Matsubayashi M., Kimata I., Furuya M., Tani H. & Sasai K. (2013). Infectivity of
Cryptosporidium andersoni Kawatabi type relative to the small number of oocysts in immunodeficient and
Annual reports of OIE Reference Centres, 2013
9
Diagnosis and Control of Animal Diseases and Related Veterinary Product Assessment in Asia
immunocompetent neonatal and adult mice. Parasitol Int., 62(2), 109-111.
Matsubayashi M., Hatta T., Miyoshi T., Anisuzzaman, Sasai K., Shimura K., Isobe T., Kita K. & Tsuji N. (2013).
High-throughput RNA sequencing profiles and transcriptional evidence of aerobic respiratory enzymes in
sporulating oocysts and sporozoites of Eimeria tenella. Infect. Genet. Evol. 18, 269-276.
Matsubayashi M., Teramoto-kimata I., Uni S., Lillehoi HS., Matsuda H., Furuya M., Tani H. & Sasai K. (2013).
Elongation Factor-1α Is a Novel Protein Associated with Host Cell Invasion and a Potential Protective Antigen
of Cryptosporidium parvum. J. Biol. Chem. 288(47), 34111-34120.
Van Calsteren MR., Gagnon F., Calzas C., Goyette-Desjardins G., Okura M., Takamatsu D., Gottschalk M. &
Sequra M. (2013). Structure determination of Streptococcus suis serotype 14 capsular polysaccharide.
Biochem. Cell Biol., 91(2), 49-58.
Takamatsu D., Arai R., Miyoshi-Akiyama T., Okumura K., Okura M., Kirikae T., Kojima A. & Osaki M. (2013).
Identification of Mutations Involved in the Requirement of Potassium for Growth of Typical Melissococcus
plutonius Strains. Appl. Environ. Microbiol., 79(12), 3882-3886.
Yamaji K., Miyoshi T., Hatta T., Matsubayashi M., Alim MA., Anisuzzaman, Kushibiki S, Fujisaki K. & Tsuji N.
(2013). HlCPL-A, a cathepsin L-like cysteine protease from the ixodid tick Haemaphysalis longicornis,
modulated midgut proteolytic enzymes and their inhibitors during blood meal digestion. Infect Genet. Evol.,
16, 206-211.
Kusumoto M., Fukamizu D., Ogura Y., Yoshida E., Yamamoto F., Iwata T., Ooka T., Akiba M. & Hayashi T.
(2013). The lineage-specific distribution of IS-excision enhancer in enterotoxigenic Escherichia coli isolated
from swine. Appl. Environ. Microbiol. (in press).
Iwata T., Chiku K., Amano K., Kusumoto M., Ohnishi-Kameyama M., Ono H. & Akiba M. (2013). Effects of
lipooligosaccharide inner core truncation on bile resistance and chick colonization by Campylobacter jejuni.
PloS One, 8(2), 375-381.
Shahada F., Chuma T., Kosugi G., Kusumoto M., Iwata T. & Akiba M. (2013). Distribution of extended-spectrum
cephalosporin resistance determinants in Salmonella enterica and Escherichia coli isolated from broilers in
southern Japan. Poult. Sci., 92(6), 1641-1649.
Shi F., Ogawa Y., Sano A., Harada T., Hirota J., Eguchi M., Oishi E. & Shimoji Y. (2013). Characterization and
identification of a novel candidate vaccine protein through systematic analysis of extracellular proteins of
Erysipelothrix rhusiopathiae. Infect. Immun., 81(12), 4333-4340.
Kawai K., Higuchi H., Iwano H., Iwakuma A., Onda K., Sato R., Hayashi T., Nagahata H. & Oshida T. (2013).
Antimicrobial susceptibilities of Mycoplasma isolated from bovine mastitis in Japan. Anim. Sci. J., (in press)
Nagata R., Kawaji S. & Mori Y. (2013). Use of enoyl coenzyme A hydratase of Mycobacterium avium subsp.
paratuberculosis for the serological diagnosis of Johne's disease. Vet. Immunol. Immunopathol., 155(4), 253258.
Okura M., Takamatsu D., Maruyama F., Nozawa T., Nakagawa I., Osaki M., Sekizaki T., Gottschalk M., Kumagai
Y. & Hamada S. (2013). Genetic Analysis of Capsular Polysaccharide Synthesis Gene Clusters from All
Serotypes of Streptococcus suis: Potential Mechanisms for Generation of Capsular Variation. Applied and
Environmental Microbiology, 79, 2796-2806.
Hanafusa Y., Phalen D. & Costa M. (2013). Infection trials in mice suggest that Macrorhabdus ornithogaster is
not capable of growth in mammals. Medical Mycology, 51(6), 669-672.
Ito H., Katsuragi K., Akama S. & Yuzawa H. (2013). Isolation of atypical genotype Actinobacillus
pleuropneumoniae serotype 6. J. Vet. Med. Sci., (in press)
Katsuda K., Hoshinoo K., Ueno Y., Kohmoto M. & Mikami O. (2013). Virulence genes and antimicrobial
susceptibility in Pasteurella multocida isolates from calves. Vet. Microbiol., 167(3-4), 737-741.
Nishijo S., Ogihara k., Ishikawa Y. & Kadota K. (2013) Signet ring cell lymphoma with plasmacytic
differentiation in a pig. J. Vet. Med. Sci., 75(6), 799-802.
Muroga N., Kobayashi S., Nishida T., Hayama Y., Kawano T., Yamamoto T. & Tsutsui T. (2013). Risk factors for
the transmission of foot-and-mouth disease during the 2010 outbreak in Japan: a case-control study. BMC
Vet. Res., 9, 150.
Hayama Y., Yamamoto T., Kobayashi S., Muroga N. & Tsutsui T. (2013), Mathematical model of the 2010 footand-mouth disease epidemic in Japan and evaluation of control measures. Prev. Vet. Med., 112(3-4), 183-193.
Kobayashi S., Hidano A., Tsutsui T., Yamamoto T., Hayama Y., Nishida T., Muroga N., Konishi M., Kameyama K.
& Murakami K. (2013). Analysis of risk factors associated with bovine leukemia virus seropositivity within dairy
10
Annual reports of OIE Reference Centres, 2013
Diagnosis and Control of Animal Diseases and Related Veterinary Product Assessment in Asia
and beef breeding farms in Japan: A nationwide survey. Res. Vet. Sci., 96(1), 47-53.
Katayama T., Saito S., Horiuchi S., Maruta T., Kato T., Yanase T., Yamakawa M. & Shirafuji H. (2013),
Nonsuppurative encephalomyelitis in a calf in Japan and the isolation of Japanese encephalitis virus genotype
1 from the affected calf. J. Clin Microbiol., 51(10), 3448-3453.
Murakami K., Kobayashi S., Konishi M., Kameyama K. & Tsutsui T. (2013). Nationwide Survey of Bovine
Leukemia Virus Infection among Dairy and Beef Breeding Cattle in Japan from 2009-2011. J. Vet. Med. Sci.,
75(8), 1123-1126.
Yanase T., Matsumoto Y, Matsumori Y., Aizawa M., Hirata M., Kato T., Shirafuji H., Yamakawa M., Tsuda T. &
Noda H. (2013). Molecular identification of field-collected Culicoides larvae in the southern part of Japan. J.
Med. Entomol. 50(5), 1105-1110.
Fukai K., Onozato H., Kitano R., Yamazoe R., Morioka K., Yamada M., Ohashi S, Yoshida K. & Kanno T. (2013).
Availability of a fetal goat tongue cell line ZZ-R 127 for isolation of Foot-and-mouth disease virus (FMDV) from
clinical samples collected from animals experimentally infected with FMDV. J. Vet. Diagn. Invest., 25(6), 770774.
Miyazaki A., Kuga K., Suzuki T., Kohmoto M., Katsuda K. & Tsunemitsu H. (2013). Annual changes in
predominant genotypes of rotavirus A detected in the feces of pigs in various developmental stages raised on
a conventional farm. Vet. Microbiol. 163(102), 162-166.
Ohkura T., Kokuho T., Konishi M., Kameyama K. & Takeuchi K. (2013). Complete Genome Sequences of Bovine
Parainfluenza Virus Type 3 Strain BN-1 and Vaccine Strain BN-CE. Genome Announc., 1(1), e00247-12.
Soma J., Tsunemitsu H., Miyamoto T., Suzuki G., Sasaki T. & Suzuki T. (2013). Whole-genome analysis of two
bovine rotavirus C strains: Shintoku and Toyama. J. Gen. Virol., 94, 128-135.
Watanabe S., Kakudo A., Ohta M., Mita K., Fujiyama K. & Inumaru S. (2013). Molecular cloning and
characterization of the α-glucosidase II from Bombyx mori and Spodoptera frugiperda. Insect. Biochem. Mol.
Biol., 43(4), 319-327.
NVAL
Hirano F., Imamura S., Nakajima N., Kawanishi M., Uchiyama M., Yamamoto K., Nagai H. and Kijima M. (2014 ).
Development of an in vitro assay based on humoral immunity for quality control of the oil-adjuvanted
Pseudotuberculosis vaccine in Yellowtail Seriola quinqueradiata. Biologicals , 42 , 48-51 .
Imamura S., Nakamizo M., Hirano F., Yamamoto T., Nagai H., Kijima M., Mekata H., Kirino Y. and Kobayashi I.
(2013). Factors Associated with Adverse Events Following Administration of Histophilus somni Vaccine to
Calves. The International Journal of Applied Research in Veterinary Medicine, 11, 3, 203-207.
Kawanishi M., Ozawa M., Hiki M., Abo H., Kojima A. and Asai T. (2013). Detection of aac(6')-Ib-cr in avian
pathogenic Escherichia coli isolates in Japan. J. Vet. Med. Sci., 75, 11, 1539-1542.
b)
International conference presentations: ......................... 15
NIAH
Nakamura K., Ohizumi T., Yamamoto Y. & Yamada M. (2013). Detection of fowl adenovirus DNA
from formalin-fixed and paraffin-embedded sections by polymerase chain reaction (PCR) and classification of
serotypes by sequencing of PCR products. 18th World Veterinary Poultry Association (WVPA, Nantes, France)
Ikehata A., Ra S., Sashita K., Paku Y., Ohkura T. & Terada H. (2013). Rapid diagnosis of anemia for
screening of bovine piroplasmosis by short-wavelength NIR spectroscopy. 16th International Conference on
Near Infrared Spectroscopy (Montpelir, USA)
Kubota T., Yokoyama M., Uchida I., Kijima M., Takata M. & Fujiwara M. (2013). Dynamic analysis
of the calcium carbonate microcapsule in chicken digestive tract. The 10th International Veterinary Immunology
Symposium (Milan, Italy)
Morozumi T., Iseki H., Doi D., Takagi M., Tsunemitsu H. & Uenishi H. (2013). AMPLIFICATION
AND SHOTGUN SEQUENCING OF GENOMIC RNA OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME
VIRUS. The 10th International Veterinary Immunology Symposium. (Milan, Italy)
Muneta Y. (2013). Experimental infection of Salmonella enterica serovar Choleraesuis to
HPCD or weaned piglets; Effect of a TLR5 SNP (C1205T). The 10 th International Veterinary
Immunology Symposium. (Milan, Italy)
Okura M. (2013). Development of multiplex PCR-based cps-typing method composed of grouping and
Annual reports of OIE Reference Centres, 2013
11
Diagnosis and Control of Animal Diseases and Related Veterinary Product Assessment in Asia
typing steps. First international workshop on Streptococcus suis program. (Beijing, China)
Tsuchiya Y. (2013). Improvement of antimicrobial activity of lysozyme by the modification of polyarginine at
the C-terminus. International Symposium of the German Society for Biochemistry and Molecular Biology.
(Frankfurt, Germany)
Ishizeki S., Ishikawa H., Adachi Y., Yamazaki Y. & Yamane I. (2013). PRIMARY TOPOGRAPHICAL
SURVEY OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS STATUS IN FARROW-TO-FINISH
SWINE FARMS IN JAPAN. The 6th Asian Pig Veterinary Society Congress. (Ho Chi Minh City, Vietnam)
Yamane I., Ishizeki S. & Yamazaki Y. (2013). Recent trends of reproductive performances in farrow-to-finish
swine farms in Japan. The 6th Asian Pig Veterinary Society Congress. (Ho Chi Minh City, Vietnam)
Van Calsteren MR., Gagnon F., Desjardins G., Brousses A., Soudier C., Okura M., Takamatsu
D., Gottschalk M. & Segura M. (2013). Explaining the serological behavior of Streptococcus suis
serotypes 1 and 1/2 from their capsular polysaccharide structure and biosynthesis. MOOT XXVI NMR
Symposium. (Ontario, Canada)
Watanabe A., (2013). Possible involvement of transforming growth factor-beta2 in the
development of bovine dry-period mastitis induced by intramammary infusion of
Staphylococcus aureus. The 31st World Veterinary Congress. (Prague, the Czech Republic)
Hayashi T., (2013). Establishment of the new ELISA assay for Staphylococcus aureus specific
antibody in bovine milk. The 31 st World Veterinary Congress. (Prague, the Czech Republic)
NVAL
Hikichi N., Standards (Minimum requiremen) for veterinary biological products and national assay in Japan.
VMP Forum, 9 October 2013.
Iwamoto S., Regulatory system of GMP for Veterinary Medicinal Products in Japan. VMP Forum, 9 October
2013.
Tsunoda T., Off-label use of Veterinari Medicinal Products. International Workshop for minor use and minor
species of veterinary medicine management. 23 October 2013.
c)
National conference presentations: ................................ 19
NVAL
Hirano F., et al. Evaluation of efficacy of the oil-adjuvanted Pseudotuberculosis vaccine in Yellowtail Seriola
quinqueradiata using agglutinating antibody titer measurement. Spring Conference of The Japanese Society of
Fish Pathology. 9 March 2013.
Hiki M., et al., Serotype and molecular epidemiological analysis of the fluoroquinolone-resistant Cempylobacter
jejuni derived from healthy broiler. The 156th meeting of the Japanese Society of Veterinary Science. 22
September 2013.
Imamura S., et al., Evaluation of usefulness of the endotoxinactivity measurement using whole blood culture
method. The 156th meeting of the Japanese Society of Veterinary Science. 20 September 2013.
Kawanishi M., et al., Antimicrobial susceptibility and the characteristics of Mannheimia haemolytica isolates in
Japan. The 156th meeting of the Japanese Society of Veterinary Science. 20 September 2013.
Hamamoto K., et al., Progression of Metoclopramid plasma level in experimental renal function deteriorated
cattle. The 156th meeting of the Japanese Society of Veterinary Science. 20 September 2013.
Ishimaru M., et al., Study of the detection method for Hobi-like Pestivirus ( bovine viral diarrhea virus type 3).
The 156th meeting of the Japanese Society of Veterinary Science. 20 September 2013.
Oishi K., et al., Histopathological study of so-called lipomatous muscular dystrophy in pig. The 156th meeting of
the Japanese Society of Veterinary Science. 20 September 2013.
Hikichi N., et al., Evaluation of the usefulness of antibody determination ELISA kit using chicken sera immunized
by Avian Influenza vaccine stockpile. The 156th meeting of the Japanese Society of Veterinary Science. 20
September 2013.
Hamamoto K., et al., Detection of cattle CYP450 2D14 protein using westen blot analysis. The 156th meeting of
the Japanese Society of Veterinary Science. 21 September 2013.
Goto M., et al., Multivariable analysis of the association between antimicrobial use and antimicrobial
resistance in Escherichia coli isolated from apparently healthy pigs in Japan. The 156th meeting of the Japanese
12
Annual reports of OIE Reference Centres, 2013
Diagnosis and Control of Animal Diseases and Related Veterinary Product Assessment in Asia
Society of Veterinary Science. 22 September 2013.
Yamamoto T., et al., Analysis of DNA gyrase and topoisomerase IV mutation in the fluoroquinolone-resistant
Actinobacillus pleuroneumoniae. The 156th meeting of the Japanese Society of Veterinary Science. 20
September 2013.
Nakamura S., et al., Development of bovine viral diarrhea virus cDNA clone and analysis of innate
immunosuppression function. The 156th meeting of the Japanese Society of Veterinary Science. 20 September
2013.
Yamamoto K., et al., Serotype and drug susceptibility of the Actinobacillus pleuropneumoniae isolated from
2008 to 2011. The 156th meeting of the Japanese Society of Veterinary Science. 20 September 2013.
Kawanishi M., The Japanese Veterinary Antimicrobial Resistance Monitoring System. The 6th meeting of
Japanese Society for Campylobacter Research. 26 July 2013.
Hiki M., et al., Contamination and drug susceptibility of the Salmonella spp in broiler chicken or chicken meat.
The 156th meeting of the Japanese Society of Veterinary Science. 22 September 2013.
Mizuno Y., et al., Residue analysis of sodium dichloroisocyanurate in the tissue from cattle and pig using LCMS/MS. The 106th meeting of Japanese Society for Food Hygiene and Safety. 21 November 2013.
Hamamoto K., et al., Residual concentration of Fenitrothion products in the cattle and pigs after withdrawal
period of aerosolized administration. The 106th meeting of Japanese Society for Food Hygiene and Safety. 21
November 2013.
Akama R., et al., Study for the analytical method of the Dibutylsuccinate in a bovine tissue. The 106th
meeting of Japanese Society for Food Hygiene and Safety. 21 November 2013.
Noda K., History of VICH; Achievements and spill over effects to the improvement of VMP governance in the
region. The 76th Conference of Japanese Veterinary History Association. Nov. 2, 2013, Tokyo, Japan. 2
November 2013.
d)
Other: ...............................................................................
(Provide website address or link to appropriate information)
_______________
Annual reports of OIE Reference Centres, 2013
13