January 2012 Monday 9 January 2012 Investigating the hereditary component of prostate cancer risk and outcomes through familial and case-control datasets Dr Liesel FitzGerald Fred Hutchison Cancer Research Centre, Seattle Host: Professor Nick Hastie Venue: MRC Seminar Room Thursday 19 January 2012 The mechanism and regulation of eukaryotic DNA replication Dr John Diffley Cancer Research UK Host: Dr Andrew Jackson Venue: MRC Seminar Room February 2012 Thursday 2 February 2012 To be announced Professor Sue Black University of Dundee Host: Professor Nick Hastie Venue: MRC Seminar Room Thursday 16 February 2012 Yeast genome evolution and the aftermath of polyploidization Dr Ken Wolfe Trinity College, Dublin Host: Dr Colin Semple Venue: MRC Seminar Room Thursday 23 February 2012 Transition states and ß-catenin signalling in self renewal and differentiation of Stem Cell populations Professor Alfonso Martinez-Arias University of Cambridge Host: Professer Nick Hastie Venue: MRC Seminar Room November 2011 Thursday 3 November 2011 Lighting up RNA Interactions in Living Cells Professor David Tollervey University of Edinburgh Host: Dr Martin Reijns Venue: MRC Seminar Room Thursday 10 November 2011 ***12-1pm*** To be announced Dr Luke O’Neill Trinity College, Dublin Host: Dr Julia Dorin Venue: ECRC Seminar Room Thursday 24 November 2011 To be announced Dr Adam Eyre-Walker University of Sussex Host: Professor Chris Haley Venue: ECRC Seminar Room December 2011 Thursday 1 December 2011 Controlling recombination Dr Simon Boulton London Research Institute Host: Professor Nick Hastie Venue: MRC Seminar Room Thursday 8 December 2011 Gene punctuation in eukaryotes: Gene loops, R-loops and Non coding RNA Professor Nick Proudfoot Sir William Dunn School of Pathology, University of Oxford Host: Professor Javier Caceres Venue: ECRC Seminar Room October 2011 Thursday 13 October 2011 Immunodeficiencies and Cilia Cambridge Institute of Medical Research Host: Professor Nick Hastie Venue: ECRC Seminar Room Thursday 20 October 2011 To be announced Professor Kevin Hiom University of Dundee Host: Dr Ian Adams Venue: MRC Seminar Room Thursday 27 October 2011 The tumour microenvironment in bone metastases- role in development and response to therapy Professor Rob Coleman and Dr Ingunn Holen University of Sheffield Host: Professor David Cameron Venue: ECRC Seminar Room September 2011 Thursday 15 September 2011 Communing with the mRNA methyl cap Dr Victoria Cowling University of Dundee Host: Professor Javier Caceres Venue: ECRC Seminar Room Thursday 22 September 2011 To be announced Professor Claus Nerlov MRC Centre for Regenerative Medicine Host: Professor Nick Hastie Venue: MRC Seminar Room Thursday 29 September 2011 Mitochondrial Genetics and Disease Professor Doug Turnbull University of Newcastle Host: Professor Alan Wright Venue: ECRC Seminar Room July 2011 Thursday 7 July 2011 Unraveling transcriptional regulation with ENCODE data Dr Jim Kent University of California Santa Cruz Host: Dr Colin Semple June 2011 Thursday 9 June 2011 How does the hair bundle process sound? The ongoing dialogue between Genetics of deafness and Hearing Physiology Professor Christine Petit Institut Pasteur, Paris Host: Professor Veronica van Heyningen Thursday 16 June 2011 Immunodeficiencies and cilia Professor Gillian Griffiths Cambridge Institute for Medical Research Host: Professor Nick Hastie May 2011 Wednesday 4 May 2011 Modulating cellular clearance to treat human disease Professor Andrea Ballabio Telethon Institute of Genetics and Medicine Naples Host: Professor Veronica van Heyningen Thursday 26 May 2011 Toll-like receptors and NOD-like receptors: fine-tuning the response to infection and inflammation Professor Luke O'Neill School of Biochemistry and Immunology, Trinity College Host: Dr Julia Dorin April 2011 Thursday 14 April 2011 Modeling tumour-related inflammation and colorectal cancer in Drosophila Dr Marcos Vidal Beatson Institute, Glasgow Host: Professor Nick Hastie and Professor Margaret Frame Thursday 28 April 2011 Genomic imprinting and its implications for the epigenetic control of gene dosage Professor Anne Ferguson-Smith Department of Physiology, Development and Neuroscience, University of Cambridge Host: Dr Sally Cross March 2011 Thursday 3 March 2011 Designing chemical tools with the cellular machinery in mind Dr Asier Unciti-Broceta (CRUK) Cancer Research UK Host: Professor Nick Hastie Thursday 10 March 2011 Tissue Fibrosis: making sense of inflammation and repair Professor John Iredale Director, Centre for Inflammation Research Host: Dr Julia Dorin Thursday 17 March 2011 Telomeres and telomerase: RNA-dependent machines at chromosome ends Dr Joachim Lingner Swiss Institute for Experimental Cancer Research Host: Dr Mary O'Connell Thursday 24 March 2011 Regulation of BMP signalling and cell fate specification in Drosophila Dr Hilary Ashe University of Manchester Host: Professor David FitzPatrick February 2011 Thursday 3 February 2011 The piRNA pathway in the Drosophila germline - an RNA based genome immune system Dr Julius Brennecke IMBA Host: Judith Recihmann Thursday 17 February 2011 Mutagenesis, Mice and Malaria along with Platelets, Porphyria and Parasites (or the genetics of the host response to malaria) Professor Simon Foote Menzies Research Institute, Tasmania Host: Dr Sally Cross Thursday 24 February 2011 How SUMO talks to ubiquitin Professor Ron Hay Wellcome Trust Centre for Gene Regulation and Expression University of Dundee Host: Dr Colin Gordon January 2011 Thursday 13 January 2011 Epigenetic engineering: Using a synthetic chromosome to determine the role of transcription in human kinetochore function Professor Bill Earnshaw The University of Edinburgh Host: Dr Andrew Jackson Thursday 20 January 2011 Human African Sleeping Sickness: basic biology and drug discovery Professor Mike Ferguson Wellcome Trust Biocentre, University of Dundee Host: Professor Nick Hastie December 2010 Thursday 2 December 2010 Developmental plasticity and systemic signalling in the control of shoot branching Professor Ottoline Leyser University of York Host: Professor Nick Hastie November 2010 Thursday 11 November 2010 Interplay between Polycomb repression and RNA polymerase II regulation genome-wide in murine ES cells Dr Ana Pombo MRC Clinical Sciences Centre Host: Professor Wendy Bickmore Thursday 18 November 2010 Coupling of transcription and splicing in yeast Professor Jean Beggs University of Edinburgh Host: Professor Javier Caceres October 2010 IGMM SEMINAR *Friday 8 October 2010* 13.00 Signalling hypoxia by protein hydroxylation Professor Peter Ratcliffe Nuffield Professor of Medicine University of Oxford Host: Professor Nick Hastie September 2010 Thursday 9 September 2010 Pathogenesis and Management of Paget's Disease Professor Stuart Ralston University of Edinburgh Host: Dr Colin Gordon Thursday 23 September 2010 Making a commitment: signaling pathways regulating cell allocation and axis patterning in the early mouse embryo Liz Robertson Dunn School of Pathology, University of Oxford Host: Dr Kirstie Lawson Thursday 30 September 2010 Epigenetic control of retrotransposons in human pluripotent cells Dr Jose Luis Garcia-Perez Andalusian Stem Cell Bank, University of Granada Host: Professor Javier Caceres June 2010 Thursday 10 June 2010 Multiple congenital malformations due to microdeletions of and close to the FOX transcription factor gene cluster at 16q24.1 Dr Charles Shaw Smith Sanger Institute Host: Dr David FitzPatrick May 2010 Thursday 27 May 2010 Bimodality in Gene Expression Levels Correlates with an Epigenetic Module Dr Sarah Teichmann MRC Laboratory of Molecular Biology, Cambridge Host: Dr Pedro Coutinho IGMM Seminars May/June 2010 Thursday 6 May 2010 Disruptions on the Highways of Cellular Signalling Professor Dario Alessi MRC Protein Phosphorylation Unit, Dundee Host: Andrew Jackson Thursday 24 May 2010 To be announced Professor Dame Linda Partridge Director, Institute of Healthy Ageing, University College London Host: Professor Alan Wright Thursday 3 June 2010 To be announced Professor Elaine Ostrander Cancer Genetics Branch, National Human Genome Research Institute Host: to be confirmed April 2010 Friday 16 April 2010 To be announced Professor Lee Niswander Howard Hughes Fellow, University of Colorado Host: Professor Ian Jackson Thursday 22 April 2010 Measuring and understanding variation in the copy number of human genes Professor John Armour University of Nottingham Host: Dr Julia Dorin Thursday 29 April 2010 To be announced Dr Pat Nolan Mammalian Genetics Unit, Harwell Host: Professor Ian Jackson February 2010 Thursday 4 February 2010 Autophagy and Neurodegeneration Professor David Rubinzstein Cambridge Institute for Medical Research Host: Dr Mary O’Connell Thursday 11 February 2010 Chromatin Structure and Regulation of it's Compaction Dr Daniela Rhodes MRC Laboratory for Molecular Biology, Cambridge Host: Professor Veronica van Heyningen January 2010 Thursday 21 January 2010 Visualisation of oskar mRNP assembly and transport Dr Anne Ephrussi Developmental Biology Unit, EMBL Host: Professor Javier Caceres Thursday 28 January 2010 Conditional mouse models of breast cancer Dr Jos Jonkers Netherlands Cancer Institute, Amsterdam Host: Dr Peter Hohenstein November 2009 Thursday 19 November 2009 How useful are stem cells for regenerative neurology Dr Siddarthan Chandran Euan MacDonald Centre for MND Research, University of Edinburgh Host: Dr Sally Cross Thursday 26 November 2009 The complex life of small RNAs Dr Eric Miska Gurdon Institute, University of Cambridge Host: Professor Javier Caceres IGMM SEMINARS February 2010 Thursday 25 February 2010 Genetics of type 2 diabetes: the end of the beginning or the beginning of the end? Professor Mark McCarthy University of Oxford Host: Dr Jim Wilson IGMM SEMINARS December 2009 Friday 4 December 2009 *12.30pm* BRAF and RAS signalling in melanoma: biology and therapies Professor Richard Marais Institute of Cancer Research Host: Professor Margaret Frame