Studies
Kim et al. 1998
Coonts et al. 1998
Bianucci et al. 1998
Cho et al. 1998
Caplanis et al. 1998
Brunel et al. 1998
Elharar et al. 1998
Animal model
Dogs
Dogs
Dogs
Dogs
Dogs
Dogs
Dogs
Sculean et al. 1998 Monkeys
Sallum et al. 1998 Dogs
Schepers et al. 1998 Dogs
Simion et al. 1999
Wetzel et al. 1999
Trombelli et al.
1999
Wikesjö et al. 1999
Persson et al. 1999
Dogs
Dogs
Dogs
Dogs
Dogs
Kohal et al. 1999 Dogs
Karatzas et al. 1999 Monkeys
Araújo et al. 1999
Dogs
Meraw & Reeve Dogs
1999
Meraw et al. 1999 Dogs
Cancian et al. 1999 Monkeys
Murakami et al. Dogs and
1999 monkeys
Machado et al. 1999
Barboza et. 1999
Hockers et al. 1999
Akimoto et al. 1999
Alliot et al. 1999
Dogs
Dogs
Dogs
Dogs
Dogs
Number of animals
4
6
18
4
6
10
20
3
5
6
6
7
4
8
4
5
2
19
6
6
4
?
Objective of the study to evaluate outcome following surgical implantation of an allogeneic, freeze-dried demineralized bone matrix-calcium sulfate composite with CS barrier in 3-wall intrabony periodontal defects to determine the degradation characteristics of an absorbable GTR barrier membrane and evaluate its effect on both soft and hard tissues
To determine the effects of autologous fibrinogen and absorbable barrier membrane on periodontal healing of canine experimental grade-III furcation defects to evaluate rate and extent of alveolar bone formation in dental implant dehiscence defects following guided bone regeneration and implantation of xenogeneic freeze-dried demineralised bone matrix to evaluate the potential of DBM alone to support regeneration of alveolar bone and periodontal attachment to histologically assess the osseointegration of non-submerged implants placed in tooth sockets immediately after extractions and the conjuctive use of bioabsorbable materials to evaluate the healing events and compare the effects of guided tissue regeneration using 3 different membranes: a weakly cross-linked bioabsorbable bovine collagen membrane; a strongly cross-linked bioabsorbable bovine collagen membrane; and a non-resorbable ePTFE membrane to investigate in monkeys the regrowth of oxytalan fibres in different types of acute and chronic periodontal defects following regenerative periodontal treatment to test the effects of a bioresorbable matrix barrier on new connective tissue attachment in surgically created defects in dogs to determine the efficacy of bioactive glass particles of narrow size range (300 to 335 microns, Biogran) in the treatment of bone defects prior to implant placement to compare the effect of three types of e-PTFE membrane, differing in permeability and surface microstructure, on tissue integration and bone regeneration to evaluate the possibility of re-osseointegration onto titanium oral implants with different surface configuration in a model of ligature-induced peri-implantitis to describe observations of wound healing following GTR including surgical implantation of the PGE1-analog misoprostol with the methacrylate composite HTRA in the critical size, supra-alveolar periodontal defect model to evaluate the effect of rhBMP-2 concentration (within ACS) on periodontal regeneration to study the effect of antimicrobial therapy of experimentally induced peri-implantitis lesions and to assess features of bone regrowth following treatment
To evaluate the effect of guided bone regeneration around non-submerged implants using different barrier membranes to evaluate the effect of PerioGlas (synthetic bone particulate) on wound healing of experimental palatal periodontal defects in monkeys to study bone formation in an experimentally-produced furcation defect in the dog. to evaluate the effect of local delivery of alendronate on bone regeneration within peri-implant defects. Peri-implant bone was examined histomorphometrically to evaluate the amount of supporting bone peripheral to the bone-implant interface to evaluate the effect of local delivery of alendronate sodium on bone regeneration around dental implants to compare the biologic behavior of BioGran and Calcitite as fillers for surgical cavities in the mandibles of 4 adult monkeys to examine the role of basic fibroblast growth factor in the wound healing and regeneration of periodontal tissues
4
2
3
2
10 to evaluate the hard tissue fill following treatment of ligature-induced peri-implantitis in dogs to clinically and histologically evaluate the demineralized freeze-dried bone membrane to regenerate alveolar ridges in dogs to test the effect of a bioresorbable membrane supported by xenografts or autografts in regenerating bone into peri-implant defects to test the principle of GBR to promote bone formation adjacent to commercially pure titanium implants placed within zero-wall defects to evaluate bone regeneration around nonsubmerged implants placed immediately in extraction sites in the canine mandible using a combination of synthetic hydroxyapatite and collagen membranes

Meraw et al. 2000
Nociti et al. 2000
Dogs
Dogs
Özmeric et al. 2000
Dogs
Sculean et al. 2000 Monkeys
Blumenthal et al.
2000
Hosokawa et al.
2000
Schliephake et al.
2000a
Ruskin et al. 2000
Monkeys
Dogs
Dogs
Dogs
9
9
6
15
5
5
9
3 da Silva Pereira et al. 2000
Chang & Yamada
2000
Dogs
Kohles et al. 2000 Monkeys
Schliephake et al. Dogs
2000b
Rossa et al. 2000 Dogs
Barboza et al. 2000 de Carvalho et al.
2000
Dogs
Dogs
Dogs
6
5
6
6
5
4
6 to determine the effects of a combination growth factor cement (GFC) on guided bone regeneration around dental implants to evaluate, morphometrically, hard-tissue healing following the treatment of ligature-induced peri-implantitis defects in dogs and guided bone regeneration and/or bone grafts to assess the effect of an absorbable collagen membrane used in guided tissue regeneration procedures in two-wall intrabony defects. to evaluate histologically in monkeys the effect of treating intrabony defects with EMD, GTR or combined EMD and GTR to investigate the use of a new graft material in baboon infrabony periodontal defects to ascertain whether the regeneration of membrane-protected bone defects can be accelerated by the controlled application of basic fibroblast growth factor (FGF-
2) using a new drug delivery system to assess bone regeneration underneath resorbable barrier membranes vs non-resorbable extended polytetrafluoroethylene (ePTFE) membranes in peri-implant defects to evaluate the effects of an osteoconductive biodegradable matrix incorporating human of recombinant transforming growth factor beta 1 (rhTGFb 1) in conjunction with barrier membranes on bone regeneration in canine alveolar ridge defects to compare, histologically and histometrically, the healing process of dehiscence-type defects treated by guided tissue regeneration with bioabsorbable polylactic acid membranes and non-resorbable expanded polytetrafluoroethylene membranes to evaluate the regenerative effect of a 25% doxycycline-loaded biodegradable GTR membrane (Doxy-M) in dogs to evaluate the regenerative healing response of five allograft mixtures via the morphology of filled, periodontal defects to evaluate the use of autogenous bone harvested during preparation of implant sites in combination with resorbable membranes for vertical ridge augmentation under 2 different defect site conditions to evaluate, both histologically and histometrically, the effects of topical application of basic fibroblast growth factor (b-FGF) associated with guided tissue regeneration (GTR) in the treatment of Class III defects surgically induced in dogs to evaluate a potential model of chronic mandibular class III alveolar ridge defect, in which to study the effect of soft tissue compression on bone induction mediated by recombinant human bone morphogenetic protein-2 to study the influence of bed preparation on the incorporation of autogenous bone grafts in mandibles