2015 FASEB Science Research Conferences
Genetic Recombination & Genome Rearrangements
July 19-24, 2015
STEAMBOAT SPRINGS, COLORADO
Organizer
Dr. Michael Lichten
National Cancer Institute
Bethesda, Maryland
Co-Organizer
Dr. Tanya Paull
University of Texas
Austin, Texas
Draft program. All speakers are confirmed, all times and titles are subject to revision.
Sunday, July 19, 2014
Time
4:00 pm – 9:00 pm
6:00 pm – 7:00 pm
7:00 pm – 8:00 pm
8:00 pm – 9:30 pm
Title/Topic Event
Conference Registration
Welcome Reception
DINNER
Keynote Speaker
Making and breaking recombination
intermediates
Stephen West, Cancer Research UK
Monday, July 20, 2014
Time
7:30 am – 9:00 am
7:30 am – 12:00 pm
9:00 am - 9:05 am
9:05 am – 12:15 pm
9:05 am – 9:25 am
9:25 am – 9:45 am
9:45 am – 10:05 am
9 February 2016
Title/Topic Event
BREAKFAST
Conference Registration
Welcome from FASEB
General session 1: Biochemical
mechanisms in recombination
Regulation of pathway progression
in homologous recombination
Pathways and mechanisms to
improve radiation resistance
Biochemical reconstitution of
FASEB on-site manager
Wolf Heyer*, University of California
Davis
Stephen Kowalzycowski, University of
California Davis
Douglas Bishop, University of Chicago
5:30 pm – 5:50 pm
Meiotic Recombination
How RecA family proteins optimize
homology searching
Morning Coffee Break
Regulation of RecBCD/AddAB
complexes by Chi
Step-by-step reconstitution of the
heteroduplex rejection reaction
TBA
TBA
LUNCH
Free time
General Session 2: Replication,
repair and recombination
Double-strand break repair in
meiotic and mitotic cells
Role of chromatin and tumor
suppressor genes in R-loop-mediated
DNA breaks and recombination
Amplification of risk resulting from
mis-routing of double-strand break
repair
Beginning at the ends: RNA-induced
Double Strand Breaks
Afternoon Coffee Break
Repair of broken replication forksmechanism and regulation
Functions of BRCA1 and BRCA2 at
stalled replication forks
Functions of RNA in DNA repair
5:50 pm – 6:10 pm
6:15 pm – 7:45 pm
8:00 pm – 10:00 pm
TBA
DINNER
Poster Session 1
10:05 am – 10:25 am
10:25 am – 10:55 am
10:55 am – 11:15 am
11:15 am – 11:35 am
11:35 am – 11:55 am
11:55 am – 12:15 am
12:30 pm – 1:30 pm
1:30 pm – 3:00 pm
3:00 pm – 6:15 pm
3:00 pm – 3:20 pm
3:20 pm – 3:40 pm
3:40 pm – 4:00 pm
4:00 pm – 4:20 pm
4:20 pm – 4:50 pm
4:50 pm – 5:10 pm
5:10 pm – 5:30 pm
Mara Prentis, Harvard University
Dale Wigley, Institute of Cancer
Research, London
Maria Spies, University of Iowa Carver
College of Medicine
Speaker selected from abstracts
Speaker selected from abstracts
Maria Jasin*, Memorial Sloan Kettering
Cancer Center
Andres Aguilera, Universidad de Sevilla
Anna Malkova, University of Iowa
Douglas Koshland, University of
California Berkeley
Gregorz Ira, Baylor College of Medicine
Ralph Scully, Harvard Medical School
Francesca Storici, Georgia Institute of
Technology
Speaker selected from abstracts
Tuesday, July 21, 2015
Time
7:30 am – 9:00 am
7:30 am – 12:00 pm
9:00 am – 12:15 pm
9:00 am – 9:20 am
9:20 am – 9:40 am
9:40 am – 10:00 am
10:00 am – 10:20am
9 February 2016
Title/Topic Event
BREAKFAST
Conference Registration
General session 3: Recombination
Mechanisms in Eukaryotes
Processing 3' ends following mitotic
DSB induction in yeast: how much
and who is doing it?
Mechanism and regulation of DNA
end resection
Genetic regulation of genome
stability in yeast
Chromosome break metabolism in
eukaryotic cells
Sue Jinks-Roberston*, Duke University
Lorraine Symington, Columbia
University
Tom Petes, Duke University
John Petrini, Memorial Sloan Kettering
Cancer Center
10:20 am – 10:50 am
10:50 am – 11:10 am
11:10 am – 11:30am
11:30 am – 11:50 am
11:50 am – 12:10 am
12:30 pm – 1:30 pm
1:30 pm – 3:00 pm
3:00 pm – 6:15 pm
3:00 pm – 3:20 pm
3:20 pm – 3:40 pm
3:40 pm – 4:00 pm
4:00 pm – 4:20 pm
4:20 pm – 4:50 pm
4:50 pm – 5:10 pm
5:10 pm – 5:30 pm
5:30 pm – 5:50 pm
5:50 pm – 6:10 pm
6:30 pm – 7:30 pm
8:00 pm – 10:00 pm
Morning Coffee Break and
Group Photo
Structural studies on DNA doublestrand break repair enzymes
TBA
TBA
TBA
LUNCH and
Meet the Speakers
Free time, Meet the Speakers
continues
General session 4: Maintenance of
Genome Integrity
The role of 53BP1 and Rif1 in DSB
repair
Biochemical analysis of mismatch
repair using reconstituted
Saccharomyces cerevisiae mismatch
repair systems
DNA double strand breaks
processing and repair pathway
choice
The molecular machines of DNA
break repair: what they look like and
how they work
Afternoon Coffee Break
Genome stability and the control of
homologous recombination
Recombination-mediated
replication: molecular pathways and
DNA structures
TBA
TBA
DINNER
Poster Session 2
Karl-Peter Hopfner, LMU Munich
Speaker selected from abstracts
Speaker selected from abstracts
Speaker selected from abstracts
Titia de Lange*, Rockefeller University
Richard Kolodner, Ludwig Cancer
Institute
Jean Gautier, Columbia University
Claire Wyman, Erasmus University
Medical Center, Rotterdam
Simon Boulton, Cancer Research UK
Dana Branzei,Milan
Speaker selected from abstracts
Speaker selected from abstracts
Wednesday, July 22, 2015
Time
7:30 am – 9:00 am
7:30 am – 12:00 pm
9:00 am – 12:15 pm
9:00 am – 9:20 am
9:20 am – 9:40 am
9:40 am – 10:00 am
9 February 2016
Title/Topic Event
BREAKFAST
Conference Registration
General session 5: Regulation of
Meiotic Recombination
Mechanism and regulation of
meiotic recombination initiation
Quality control and feedback
mechanisms governing meiotic
recombination in C. elegans
Mechanisms of meiotic
recombination by post-translational
modifications
Scott Keeney, Memorial SloanKettering Cancer Center
Anne Villeneuve*, Stanford University
Neil Hunter, University of California,
Davis
10:00 am – 10:20am
10:20 am – 10:50 am
10:50 am – 11:10 am
11:10 am – 11:30am
11:30 am – 11:50 am
11:50 am – 12:10 am
12:30 pm – 1:30 pm
1:30 pm – 4:30 pm
4:30 pm – 6:30 pm
6:30 pm – 7:30 pm
7:30 pm – 10:00 pm
Genetic, biochemical, and structural
studies of Drosophila Holliday
junction resolvases
Morning Coffee Break
Crossover interference
TBA
TBA
TBA
LUNCH and
Meet the Speakers/Expert
9:10 pm – 9:30 pm
Free time
Poster Session 3
DINNER
General Session 6: Recombination
mechanisms in prokaryotes
Repair and Reactivation of Stalled
Replication Forks
Signalling blocked replication in
bacteria
Cataclysmic events in stationary
phase bacterial chromosomes fragile sites
Break (no coffee)
Illuminating homologous
recombination in live bacteria
The DNA damage-control network
9:30 pm – 9:50 pm
TBA
7:30 pm – 7:50 pm
7:50 pm – 8:10 pm
8:10 pm – 8:30 pm
8:30 pm – 8:50 pm
8:50 pm – 9:10 pm
Jeff Sekelsky, University of North
Carolina Chapel Hill
Nancy Kleckner, Harvard University
Speaker selected from abstracts
Speaker selected from abstracts
Speaker selected from abstracts
Kenneth Marians*, Memorial SloanKettering Cancer Center
Sue Lovett, Brandeis University
John Roth, University of California Davis
David Sherratt, University of Oxford
Susan Rosenberg, Baylor College of
Medicine
Speaker selected from abstracts
Thursday, July 23, 2015
Time am – Time pm
7:30 am – 9:00 am
9:00 am – 11:55 pm
9:00 am – 9:20 am
9:20 am – 9:40 am
9:40 am – 10:00 am
10:00 am – 10:20am
10:20 am – 10:50 am
10:50 am – 11:10 am
11:10 am – 11:30am
9 February 2016
Title/Topic Event
BREAKFAST
General session 7: Patterns and
mechanisms of genome
rearrangement
Increasing genetic diversity:
methods, consequences and
applications
“Insights into mutational processes
from large-scale sequencing of
cancer genomes
Cancer genome instability and
hypermutation
Chromatin remodeling during
double-strand break repair
Morning Coffee Break
Circumventing replication barriers:
Pif helicases to the rescue
TBA
Alain Nicolas*, Institut Curie, Paris
Peter Campbell, Sanger Institute
Dmitry Gordenin, National Institute of
Environmental Health Science
James Haber, Brandeis University
Ginger Zakinan, Princeton University
Speaker selected from abstracts
11:30 am – 11:50 am
11:50 am – 12:20 pm
12:30 pm – 1:30 pm
1:30 pm – 3:00 pm
3:00 pm – 6:15 pm
3:00 pm – 3:20 pm
3:20 pm – 3:40 pm
3:40 pm – 4:00 pm
4:00 pm – 4:20 pm
4:20 pm – 4:50 pm
4:50 pm – 5:10 pm
5:10 pm – 5:30 pm
5:30 pm – 5:50 pm
5:50 pm – 6:10 pm
6:30 pm – 7:30 pm
8:00 pm – 12:00 am
TBA
Business Meeting
LUNCH
Free time and Catch-up Poster
Session
General Session 8:
Chromatin/chromosome/nuclear
dynamics during recombination
A chromatin twist into genetic
recombination and genome
rearrangement
Pathways and mechanisms
influencing ATR activation
TBA
Genetic control of chromosome
mobility
Coffee Break
The ins and outs of double-strand
break repair in heterochromatin
Chromatin function in DNA double
strand break repair
Nuclear position on the regulation of
DNA repair pathway choice
TBA
DINNER
Special event: ENTERTAINMENT
Friday, July 24, 2015
Time am – Time pm
7:30 am – 9:00 am
9:00 am
Title/Topic Event
BREAKFAST
Boxed Snacks to Go
And DEPARTURES
END OF CONFERENCE
For additional information contact:
FASEB Science Research Conferences
9650 Rockville Pike
Bethesda, MD 20814
www.faseb.org/src
9 February 2016
Speaker selected from abstracts
Genevieve Almouzni*, Insitut Curie
Marco Foiani, IFOM Milan
Stefan Jentsch, Max Planck Institute of
Biochemistry, Munich
Rodney Rothstein, Columbia University
Irene Chiolo, University of Southern
California
Gaelle Legube, Université Paul Sabatier,
Toulouse
Evi Soutoglou, Université de Strasbourg
Speaker selected from abstracts