Class meets Apr 2 to May 23
2013
.5
1.5hr
Course intro
2
1
1
Introduction
Course format
Course requirements
Introduction / Human
Genetic Variation
Salari_2009*
HamburgSalari_2011*
Bioethics presentation
Put in middle of schedule
2 hr debate: "Should DTC
genetic tests by prescription
only?"
Linkage
SNPs
2 hr Traits
LD blocks
Problem set 1 out
1 hr
Stuart
Rosalind
Pearson*
Manolio
GWAS1
GWAS2
GWAS3
GWAS
SNPedia introduction
Class GWAS
Ancestry
Height vs parents height
0.5 Whodunit?
Neanderthal evolution
1
Workshop
Workshop
Visscher
Green 2010
23andme
2 Cancer genomics, Breast cancer
0.5?
1? Genomic Convergence
Human positive
1
selection (Stuart)
1 Frontiers in human genetics
2 hr Neurological Disease
LIll 2011
Aaron Gitler
Lill 2012
Rosalind Chuang
Do 2011
Intro to pharm
2
2
2
terrific!!!
Pharmacogenetics
Russ Altman
Atul Butte
Mike Snyder
Intro to eQTLs
2
Big datasets
Expression
Terrific
Future tech
Lots of potential to do
something creative.
Stephen Montgomery
2
Euan Ashley
2
Presentations of SNP writeups
Presentation of class survey
(Nate Cira)
Class evaluation
Class Discussion
neonatal sequencing
2
Psychiatric disorders
2
Heart
Jon
Bernstein/Rosa?
Date Second string
Presenter
Tue
April Heart Disease
2
Tim Assimes
Thur
Interpreting Genomic Data
April
in Clinical Medicine.
4
Ancestry
Tue
Problem set 1 due
April
via email (Answers)
9
Problem set 2 out
Thur
April Carlos Bustamente
11
Tue
April Tim Assimes
16
Thur
April Emmanuel Mignot
18
Tue
Great talk, but too
introductory
Readings
CVD2012a*
CVD2012b
CVD2011a
CVD2011b
Euan Ashley
Evaluation Form
Carlos
Bustamante
Various
Auton 2009
Bryc 2010
Novembre 2008
Standard research talk,
no preparation
Kind of dry
Heart
Narcolepsy
Interesting, but not
really related to class
April
23
Thur
April
25
Tue
Apr
30
Thur
May
2
Tue
May
7
Thur
May
9
Tue
May
14
Thur
May
16
extra
extra
extra
extra
extra
Next generation
Thur sequencing.
June Final exam out
7
Extra credit out
Final exam & extra credit
June
due at midnight
13
viaemail (Answers)
Workshop
Workshop
Mike Snyder
Ideas for advanced projects:
algorithm for efficient sequencing of a population
exome data/analysis of Gitler data?
write an RPGEH grant
analyze Stuart Genome and Aaron.