ENGR0011 Section Bursic, 2:00 Group #L10 DISCREPENCIES IN ACL RECONSTRUCTION IN CHILDREN WITH IMMATURE GROWTH PLATES AND ITS ECONOMIC EFFECT Kyle Berkow (KAB259@pitt.edu) THE HUMAN KNEE AND INJURIES TO THE ACL What Are The Problems With ACL Reconstruction? As a freshman majoring in biomedical engineering with a passion for athleticism and movement, one topic that shows opportunity for plenty of advancement in the future is the recovery from sports related injuries. Currently, I am volunteering at Dr. Richard Debski’s Shoulder and Knee Dynamics Lab. This lab does studies in relation to injuries that occur both in the shoulder and the knee, allowing them to consult with doctors and other professionals in order to advance surgical procedures as well as day to day care. One study that has sparked my attention is the many ways of rebuilding or engineering a new ACL. Orthopedic surgeons currently have a method of doing this, yet it is not practical for the younger population of injured athletes. The debate with this issue is simply the argument of whether or not time and money should be spent to develop new methods of engineering a new ACL and to then educate doctors in these new advancements. The reasoning against the development of a new process is that it will be costly, will require time taken away from these practicing doctor’s already overloaded schedules, and will develop arguments of ethical uses over stem cell research. Still, time and money should be spent towards allowing patients to receive the most modern advancements in surgeries, which will decrease reoccurring injury and benefit our society in healthcare costs. Personally, I see that the longer the time spent recovering from an injury, the harder it becomes for all athletes and individuals to return back to their normal way of life. Simply speaking, new advancements in recovery from surgeries caused by injuries to young athletes will allow a quicker return to the sport along with the relief that such injury will be less likely to occur. Anatomy of the Knee The knee consists of bones, tendons, ligaments, and cartilage, all of which connect to stabilize our motion in the knee. The femur, tibia, and patella are the bones that make up the knee structure; these bones are held stable by the medial collateral (MCL), lateral collateral (LCL), posterior cruciate (PCL), and anterior cruciate (ACL) ligaments. Cartilage sits between the femur and tibia, acting as a shock University of Pittsburgh, Swanson School of Engineering 10/30/12 1 absorber for the bones [1]. Together, these three structures help us perform everyday physical activities. The anterior cruciate ligament (ACL), which runs diagonally between the femur and tibia, connects the femur and the tibia, preventing movement out of alignment. The ligament’s job is to prevent the tibia from going in front of the femur, providing stability when rotating the knee during arduous exercise and swift movements. ACL Injuries The most commonly injured ligament within the knee is the ACL, amounting to hundreds of thousands of injuries each year. The American Orthopedic Society for Sports Medicine claims “about 150,000 ACL injuries occur in the United States every year” [2]. Injuries to the ACL are normally caused by a rapid or sudden change in direction, a sudden stopping action, an incorrect landing from a jump, or a direct contact or collision [3]. Injuries of change in motion and mechanical movement account for about 70 percent of ACL injuries [2]. ACL injuries are especially seen in sports with rapid movements, such as soccer, basketball, and hockey. ACL injuries are also seen in contact sports such as football and rugby, which account for only 30 percent [2]. Although there is no rapid movement or contact, I am currently focusing more on triathlon’s making both shoulder and knee injuries for swimming and running a major interest for myself. Also, studies have shown that females are more prone to ACL injuries than men due to muscular development, strength, and physical condition [3]. Signs and symptoms of ACL injuries are easily spotted. When the ACL tears, a popping sound can usually be heard as the knee gives out. A tear in the ACL literally causes the ligament to split into two strands, which are then not strong enough to keep the femur and tibia in place. This then will cause extreme pain in everyday motions such as walking. Alongside that, there is normally swelling, tenderness, and loss of motion during an injury of this sort [3]. Based on the severity of the tear, either reconstructive surgery or physical therapy is advised. Even though I have not personally been exposed to an ACL injury occur, I do know many peers who have already torn this ligament and have required surgery. Kyle Berkow In addition, with the increase in activity, preventative initiatives must be made more readily available. Exercises and activity to prevent ACL injuries could potentially reduce the number of ACL tears and also the economic impact. Young athletes are usually unaware of the consequences of limited strength and flexibility in certain parts of the body, which cause these injuries. If the athletes are more accustomed to preventative activities that will reduce these risks, less injuries will occur. Together, a more stable engineered ACL and preventative exercises will decrease the risk of further injury, which will in turn promote lower costs to the family and to the healthcare system as a whole. ACL TEAR The ACL above has completely torn into two pieces, providing no stability [1] ACL Injuries in Children and What Action We Should Take Treatment Options Nonsurgical Treatment Nowadays, children are more prone to injuries, shown by the increase in ACL tears. While ACL tears used to be more heavily concentrated in the 20-30s population, it has begun to trickle down towards younger age groups. Coaches and parents, by pushing for more strenuous training at younger ages, have started to make all sports more and more demanding for children. As both a swimmer and runner, I am performing close to three or four hours a day. Firsthand, I have seen that this push comes with greater risk, especially with children who are underdeveloped physically. This is key, as children have not reached skeletal maturity until “1213 [years of age for] girls and 14-15 [years of age for] boys” [4]. It is during this period that they are experiencing the same injuries as their adult counterparts. Very few surgical options are available to children with ACL injuries due to their immature growth plates, causing higher risk for injury to the knee. New options for surgical treatment are becoming readily available with advancements in technology; however, this will take plenty of training for the surgeons who are not accustomed with such methods. These doctors need to become more knowledgeable with other methods of treatment so that children may be treated just as well as adults while also receiving the most advanced method of treatment available. If these kids are not treated with the most modern advancements in the field, they will live without the best possible recovery. New advancements are allowing for quicker recovery time and less of a chance of a similar injury occurring. I have been injured in numerous places ranging from my knee to my back, all which have had some type of reoccurrence. Therefore, giving these young athletes the peace of mind is more than worth the time to train these doctors. If the patient is older and does not wish to interact in physical sports later on, a nonsurgical treatment is advised. Usually, this method of treatment is recommended for elder people with limited mobility to begin with, as surgery would be unnecessarily difficult for a patient whose ligaments and bones will only grow weaker after the injury. A knee brace and physical therapy is a common form of nonsurgical treatment in order to protect the knee’s stability as the ACL would have done [1], [3]. Surgical Treatment If the patient is young and wants to continue to be active the rest of his life, reconstructive surgery is usually recommended for an ACL injury. The process of an ACL reconstruction is a rebuilding of the split ligament. The ACL cannot be sewn back together because it has been proven to tear again over time. Therefore, a new method has become prevalent; doctors choose a location to take a piece of a ligament from another location close to the knee and replace the ACL [1]. The most common ligaments used to replace the ACL are from the patellar tendon, hamstring tendon, and quadriceps tendon. The graft can be taken from either the injured patient or a cadaver, which is a donated portion of a deceased body [1]. Yet, how do they replace the torn ligament? Surgeons with drill holes into the growth plates on both sides of the knee in a diagonal alignment and will fuse the tendon into position. This process allows the new tendon to act as the 2 Kyle Berkow ACL does by limiting the tibia from repositioning in front of the femur [1]. plate of a child, which can more than likely fracture the growth plate, adding more pain than relief. ACL TEARS IN CHILDREN WITH IMMATURE GROWTH PLATES ECONOMIC EFFECT OF ACL RECONSTRUCTION AND PHYSICAL THERAPY Problems with Treatment Options for Children The effect of so many injuries and surgeries plays a vital part in our healthcare system. A reconstructive surgery can be anywhere from $4800 to $5500 per surgery [6]. With the number of ACL injuries close to 200,000 per year, billions of dollars are being spent on surgery to repair ACLs. These are only the costs for surgeries. Once a part of the body has been injured, it is more prone to injury again. There is a higher risk for those who have already torn their ACLs before. In addition to surgery, both adults and children must go through a phase of physical therapy to work back to their previous physical condition. Time and energy of our healthcare professionals is spent leading these patients back to normal lives. For a child, the choice is not clear. Either way, our healthcare system will spend millions on the continual care of these children injured at such a young age. There is a solution to this increasing cost to our healthcare system, one that could benefit not only the children with ACL injuries. A new method of ACL reconstruction has been found, but it requires slightly more money and time devoted to the professionals in order to learn a newer method. The introduction of this new method of reconstruction is expensive in itself, yet it will be cost efficient in the long run. How will this new method be cost efficient? Compare the new method of surgery to alternative energy sources. The new method has been proven to allow quicker recovery and a more stable ACL, yet it will be more time consuming for the doctor’s to create and master. Our energy source has mainly come from gasoline and oil, but our society could benefit from alternative energy sources in the long run if an investment cost is spent to start the process. Time and money must be spent to better educate orthopedic surgeons in this method of ACL reconstruction in order to minimalize the recovery process and decrease healthcare costs for the patient’s future. In addition, the main goal of all engineers is to provide a more economical way of reproducing a similar result. We already have a method for ACL reconstruction, yet a better method could replace it, which will be cheaper and cause less recovery time. Therefore, research in this field and Children are part of the category that do not fall into either the surgical option or the nonsurgical option, creating discrepancies in treatment choices. Children still wish to be active later on in their own lifetime, making the procedure of drilling through a child’s growth plates an unviable option. Therefore, doctors argue whether they should recommend surgery or should choose to go for a nonsurgical treatment until the child reaches “skeletal maturity” [5]. Why is it recommended to wait until “skeletal maturity”? The answer is that surgery requires drilling into the growth plate of children, which can stunt growth by damaging these plates [5]. Yet, recent research has shown that there is less risk in damaging a growth plate than disregarding a torn ACL altogether. The problem is clear: surgery will stunt growth by drilling into the growth plates in the bone while no treatment at all will cause permanent damage to the knee. Damage caused at this young of an age will create health issues in other parts of the body, leading to more surgeries and extensive physical therapy. The disproportions in bone growth will cause imbalanced walking. These young children will be incapable of returning to normal physical activity. I would be devastated to find out I am no longer able to continue normal everyday physical activity if in this position. In addition, each health risk adds to the society’s increase in healthcare costs, which keeps rising every year. Growth Plates Growth plates are “the area at the end of long bones in children and adolescents that allows the bones to grow” [4]. The “plate” refers to the cartilage cells that regenerate new cells to make the bone longer [4]. These cells are necessary to have normal bone growth. If the bone does not grow to normal length, other injuries are more prone. Injuries to the growth plate also have their own longterm effects. Any injury can cause the “separation of that bone at the growth plate, fractures of the bone across the growth plate, or crushing of the growth plate” [4]. ACL reconstructive surgery drills a hole in the non-mature growth 3 Kyle Berkow education to orthopedic doctors will be beneficial physically as well as economically. [9]. Much can be done to reduce the healthcare cost to our up and coming athletes of the future. WHAT ARE THE MOST RECENT ADVANCES IN ACL RECONSTRUCTION? ETHICALLY, THESE DOCTORS SHOULD PERFORM THESE TASKS Sports Medicine doctors have created a more advanced method to reconstruct a patient’s ACL. The earlier method was to place a second “ligament” taken from a graft beside the original torn ACL, adding greater stability. The problems with this include the damage to the patient’s growth plates and long recovery time. More recently, a modern method called the “double bundle” repair can use a harvest of the original ACL and place the new ligament in the “exact center of the original position of the patients own ACL” [7]. Orthopedic surgeon Dr. John Vitolo claims that his patients are experiencing less post-operative pain and are returning to activities faster [8]. On the other hand, this new method requires engineering a new strand of the original ligament, which requires using stem cells, an extremely controversial topic. What needs to be done about this new method of treatment? Doctors should be better educated about the new treatment, which will take funding to advance their education. Also, this new method can lead to more advanced methods, creating room for more research to this type of injury’s necessary recovery. A common injury such as ACL tear should have more advancements than it already does. Economically, this new method will benefit our system’s healthcare needs as well. This new method has been said to decrease the risk of developing arthritis later in life by staying was from the bone’s growth plates [8]. The initial push for better knowledge will not be cost efficient at first, but it will create less health risks for the future, and therefore, greater post-operative success. As an engineer, another one of our goals is to perform tasks to the best of our ability in order to help others, whether it may be creating the ability for someone to walk or creating a stable bridge for millions of cars to travel over every year. We are held responsible for the “safety, health, and welfare” of the public [10]. In the rebuilding process or the engineering of a new ACL, these biomedical engineers are held accountable for the health of each patient. That means that if it is known that one method of surgery will only provide relief for 10 to 15 years, but has a small percentage of reoccurrence, then these engineers are still putting each patient’s health at risk. It is true that “engineers shall perform services only in the areas of their competence” or “only when qualified by education or experience” [10]. Yet, I am promoting the education of such new methods to these doctors in order to allow to best recovery possible from such an injury. We, as humans, are limited by our physical ability. I will never accept that a physical constraint cannot be overcome in order to provide normal everyday activity. Our society can always improve and make advancements. In my experience, the track someone takes does not always seem to be the most appropriate, yet it happens to be the most suitable based on financial and other influences. For example, the most recent occurrence was the last high school graduating class’s choice of where to attend college. Some of the smartest and most talented students should have attended the University of Pittsburgh and other highly qualified four-year institutions such as the Ivy League schools, yet their economic and familial influences did not allow him or her to make such a choice. Similarly, these doctors may very well agree with my opinion to promote more research in this area and educate doctors, but in reality, these doctors are not willing to give up their time or spend the money to be better educated on such issues. I still stand for these advancements because these initial investments will provide less costly recovery from such injuries. Therefore, our society should look ahead and take the risk of spending and invest in our society’s future of the most modern advancements. Still further, our biomedical engineers are constrained by their compliance with “legal, ethical, governmental, and PREVENTATIVE CARE With such a large number of injuries in one specific field, young athletes should be educated on the methods of preventative care for their knees. Most athletes are not very well educated on the risks of a lack of stretching and warming up. Considering 70 percent of ACL tears come from noncontact movement, simple exercises could decrease the number of patients each year, especially in young children. Exercises in plyometrics, core stability, and dynamic muscular control could possibly decrease the number of injuries to young athletes will greater potential 4 Kyle Berkow other applicable research guidelines” when conducting research for these advancements [11]. As stated previously, the most modern method of ACL reconstruction, the “double bundle” repair, which involves the use of stem cells and the re-creation of already living cells. While many may call this therapeautic cloning, others deny the sound logic in any sort of cloning or reproduction in any cellular form. Yet, I can still see plenty of advancement with the need to overstep any boundaries of cloning or inappropriate use of stem cells while reconstructing a torn ACL. are selecting careers other than engineering”, which is most often “attributed to low status and poor general perception by the public for engineering” [12]. Students are often discouraged to pursue certain careers because they are unaware of what that career entails. By doing this project, I can see exactly what type of research a biomedical engineer is capable of doing, and I can decide whether this is in fact the right field for me. SO, WHAT SHOULD WE DO ABOUT ACLS? DOES OUR EDUCATION THUS FAR RELATE TO THESE ISSUES? Healthcare costs and costs of medical insurance are rising tremendously over recent years. Our society can benefit from greater care at lower costs to our hospitals and insurance companies. More advanced surgical methods that will reduce post-operative recovery time, as well as health issues in the patient’s future, will come as a benefit to both the patient and our economy. We must always strive to teach our doctors the most efficient and effective way to treat injured patients in order to create the greatest outcome. Time and money must be spent furthering advancements in surgery for ACL reconstruction as well as the education to orthopedic surgeons in modern methods. It is our duty as engineers and as students to help others with further advancements through our research and education. Furthermore, our young populations of athletes need to be educated in the prevention of such injuries to reduce the risk. Our economy will benefit as well as our health. Over the last decade or so, the approach to education has changed. No longer does good grades and a solid background guarantee an engineer a job. Research, real life experience, and extracurricular activities are becoming more important as admissions workers struggle to differentiate different applicants. Over the past year, I myself have seen these pushes for well-roundedness when applying to colleges and scholarships. Within our education system, “education to improve our future engineers is by no means new, but there is a new found emphasis on research and other forms of scholarship to inform engineering education activities” [12]. Very few engineers at the University of Pittsburgh will finish all four years without some application of his or her work, whether it may be in getting an internship or doing research in his or her field. This project was worth our time and focus as freshman engineers because our education as students depends on our motivation. We were all encouraged to choose topics that we have some interest in, which will then build drive and motivation to learn more about these topics. Yet, I believe that by researching this topic, while it opened our eyes to the interests that we as engineers do enjoy, we are still not fully able to understand the phenomena of the research and the politics involved. I can research the advancements in ACL reconstruction until I find all of the necessary information to fully explain its processes, yet I do not know the anatomy and physical constraints of the research, whether it may be the political issues such as the controversy of stem cells, or the inability for research labs to be funded due to the economy. Overall, this research was worth our time as a freshman engineer because it also showed us what our future field has to offer. It true that “in many nations, the brightest students REFERENCES [1] (2009). “ACL Injury: Does It Require Surgery?” American Academy of Orthopaedic Surgeons. (Online article). http://orthoinfo.aaos.org/topic.cfm?topic=A00297. [2] E. Coleman. (2011). “Statistics On ACL Injuries In Athletes.” Livestrong.com. (Online article). http://www.livestrong.com/article/548782-statistics-on-aclinjuries-in-athletes/. [3] (2009). “Anterior Cruciate Ligament Injuries”. American Academy of Orthopaedic Surgeons. (Online article). http://orthoinfo.aaos.org/topic.cfm?topic=a00549. [4] (2012). “Sports Medicine: Growth Plate Fractures.” Childrens Medical Center Dallas, Texas. (Online article). http://www.childrens.com/specialties/sports-medicine/whatwe-treat/growth-plate-fractures/. 5 Kyle Berkow [5] J. Cluett. (2012). “Should My Child Have ACL Surgery?” Orthopedics About.com. (Online article). http://orthopedics.about.com/od/aclinjury/f/children.htm. [6] S. Nagda, G. Altobelli, K. Bowdry, et al. (2009). “Cost Analysis of Outpatient Anterior Cruciate Ligament Reconstruction: Autograft versus Allograft.” National Center for Biological Information. (Online article). http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853669/. [7] A. Allen, D. Altchek, S. Rodeo. (2009). “ACL Reconstruction: New Advances in ACL Surgery.” HSS Sports Medicine Service. (Online Report). http://www.hss.edu/conditions_acl-reconstruction-newadvances.asp. [8] J. Vitolo. (2012). “Advances in ACL Surgery: Anatomic Reconstruction.” Patch Network. (Online Report). http://jefferson.patch.com/blog_posts/advances-in-aclsurgery-anatomic-reconstruction. [9] L. Kramer. (2010). “Understanding and Preventing Noncontact ACL Injuries.” Athletic Training and Sports Health Care. (Online Report). http://www.healio.com/orthopedics/journals/ATSHC/%7B2 F894C3E-2B85-4D30-93747293CBBD4784%7D/Understanding-and-PreventingNoncontact-ACL-Injuries. [10] (2012): “NSPE Code of Ethics for Engineers.” National Society of Professional Engineers. (Online Article). http://www.nspe.org/Ethics/CodeofEthics/index.html [11] (2012): “Biomedical Engineering Society Code of Ethics.” Biomedical Engineering Society. (Online Article). http://www.bmes.org/aws/BMES/pt/sp/ethics [12] M. Borrego, J. Bernhard. (2011): “The Emergence of Engineering Education as an Internationally Connected Field of Inquiry.” Journal of Engineering Education. (Print Article). Vol. 100. No. 1. pp. 14-47 ACKNOWLEDGMENTS I want to thank Beth Bateman Newborg for giving this writing assignment, as it helped me focus on which aspects of bioengineering I truly love and wish to pursue. I also would like to thank Dr. Richard Debski for letting me understand the anatomy of the knee and the issues involved with such injuries. 6