CURRICULUM VITAE
James E. Trosko, Ph.D.
March 2009
PERSONAL DATA
Birth date: April 2, 1938
Birthplace: Muskegon, Michigan
Marital Status: married, one child
Citizenship: U.S.A.
Office Address:
Dept. Pediatrics/Human Development
College of Human Medicine
Michigan State University
246 Food Safety and Toxicology Bldg.
East Lansing, MI 48824-1302
Telephone: (517) 353-6346
Fax: (517) 432-6340
E-mail: james.trosko@ht.msu.edu
Present Rank:
Home Address:
1630 Sylvan Glen
Okemos, MI 48864
(517) 349-0449
Professor, Department of Pediatrics & Human Development
EDUCATIONAL BACKGROUND
Central Michigan University, Mt. Pleasant, MI, B.A., 1960
Michigan State University, East Lansing, MI, M.S., 1962; Ph.D. 1963 (Radiation Genetics)
ACADEMIC APPOINTMENTS AND AWARDS
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Student research assistant at Central Michigan University, 1956-59.
Student-aid, Argonne National Laboratory, Summers of 1959 and 1960.
National Defense Education Act Predoctoral Fellow, Michigan State University, 1960-63.
Graduate teaching assistant, Michigan State University, Summer, 1963.
Graduate research assistant, Michigan State University, Biophysics Department,
Summer, 1964.
Oak Ridge National Laboratory Postdoctoral Fellow, 1963-64.
American Cancer Society Postdoctoral at Oak Ridge, 1964-65.
Part-time tutorial instructor in Upward Bound project at Knox College in Knoxville, TN,
Summer, 1964.
Staff research biologist, Oak Ridge National Laboratory, 1965-66.
Asst. Professor, Department of Natural Science, Michigan State University, 1966-70.
Recipient of All University Grant #5087 ($3000), 1966-67.
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Recipient of Bio-medical Support Grant #1-SO5FR07049-01 ($3500), 1966-67.
Recipient of American Cancer Society Institutional Grant #IN-44H $3000.
Recipient of Atomic Energy Commission Contract AT (11-1)1704 ($36,200) 1967-68.
Recipient of All University Grant #5586, 1967-68.
Recipient of Atomic Energy Commission Contract Renewal ($29,863) 1968-69.
American Men of Science, 1967.
Recipient of All University Grant #6044 ($300) 1968-69.
Given dual appointment with Department of Human Development, 1969.
Recipient of Atomic Energy Commission Contract Renewal ($29,860) 1969-70.
Transfer to Department of Human Development and Justin Morrill College, Spring 1970.
Recipient of MSU Teacher-Scholar Award for 1970.
Recipient of Atomic Energy Commission Contract Renewal ($26,500 1970-71.
Recipient of General Research Support Grant ($1,400) 1970-71.
Recipient of Biomedical Science Support Grant ($5,000) 1970-71.
Recipient of Atomic Energy Commission Contract Renewal ($15,900) 1971-72.
Trainee in Summer Workshop in Developmental Biology at University of California at
LaJolla, Summer 1971.
Received an Outstanding Educator of America Award, 1971.
Promoted to Associate Professor of Human Development, College of Human Medicine,
Michigan State University, 1971.
Recipient of National Institutes of Health Career Development Award (National Cancer
Institute) for 5 years 1971-77.
Recipient of NIH-NCI Research Grant (1-RO1-CA1304-01) RAD ($24,227) for 1972-73.
Research Leave of Absence - Visiting Professor of Oncology and Bioethics at the
University of Wisconsin (Dr. Van R. Potter, McArdle Laboratory of Cancer Research).
Recipient of NIH-NCI Research Grant (1RO1-CAl3048-01) RAD ($24,288) for 1972-74.
Recipient of NIH-NCI Research Grant (2RO1-CA13048-03) RAD ($52,379) 1974- 75.
Led Provost-Faculty Seminar for Spring term, 1974, on "Scientific Concepts of Human
Nature and Their Implication to Ethics".
Promoted to Full Professor of Human Development, College of Human Medicine,
Michigan State University, 1976.
Recipient of a National Foundation Grant (#67-77) $40,000) for 1976-78.
Recipient of a National Cancer Institute Grant (CA21104) $143,000 for 1977- 80.
Served on the Argonne National Laboratory Biology Committee (1977-80).
Elected Vice-President of the Michigan Branch of the Tissue Culture Association
(1977-78).
Elected President of the Michigan Branch of the Tissue Culture Assoc. (1978-79).
Editorial Advisor Environmental Carcinogenesis and Mutagenesis 1978- present.
Participant in a NIH-NSF Workshop, "Philosophical Ethics for Scientists and Engineers",
held at Georgetown University, Summer, 1978.
Recipient of an NCI Supplemental Grant (CA21104-S) for 1979-80.
United Kingdom-Environmental Mutagen Society's "Searle" Award for pioneering
research on DNA repair in mammalian cells. Sept., 1979 (University of Sussex,
England).
Recipient of NCI Grant (CA26803), Sept. 1980-Aug. 1984.
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Appointed Acting Associate Chairman of the Department of Pediatrics and Human
Development, Michigan State University, Sept. 1980-Aug. 1982.
Recipient of NCI Grant (CA21104), April 1984 - March 1987.
Sigma Xi Senior Research Award, Spring, 1985.
Appointed member of Organ Systems Program, Pancreas Cancer Working Group, April,
1985.
Organized Society of Toxicology's symposium on "The Role of Gap Junctions in
Toxicology", New Orleans, March, 1986.
Organized Environmental Mutagen Society's workshop on "Mechanisms of Tumor
Promotion", Baltimore, MD, April 8, 1986.
Organized Tissue Culture Assoc. workshop on "Problems in In Vitro Carcinogenesis
Studies".
Appointed to State of Michigan's Critical Materials Register Advisory Committee, Fall,
1985 - Fall, 1987.
Recipient of Air Force Office of Scientific Research grant, Feb. 1986 - Jan. 1989.
Recipient of Education Foundation of America grant, Sept. 1986 - Sept. 1987.
Recipient of the Distinguished Faculty Award, Feb., 1987.
Certified as a "Diplomat of General Toxicology" by the Academy of Toxicological
Sciences, August, 1988.
Participant in the "Workshop in Somatic Cell and Molecular Genetics", sponsored by the
N.C.I. at the University of Colorado Health Science Center, July 18-30, 1988.
Recipient of the American Oil Chemists' Society award for "Outstanding Paper
Presentation".
Recipient of an NIH-Shared instrument grant.
Recipient of a grant from R.J. Reynolds, Inc., 1986-89.
Recipient of a U.S. Defense Dept. large instrument grant, 1989.
Recipient of USAFOSR Grant, 1989-91.
Appointed to Governor Blanchard's "Commission on Chronic Diseases", 1989-1990.
Recipient of a NIEHS Grant, 1989-93.
Consultant to the Great Lakes Science Advisory Board Health Committee, March, 1989.
Appointed to MSU's "Corrage" Committee (Council on Review of Research and Graduate
Education).
Appointed as Chief of Research, Radiation Effects Research Foundation, Hiroshima,
Japan, July 1990 - August 1992.
Central Michigan University's Centennial Award Recipient, 1993.
Recipient of a research "gift" from the Acrylonitrile Group for $80,000, 1994.
Recipient of a Michigan Great Lakes Protection Grant of $160,000, 1994-96.
Member of NIH Chem-Path Study Section, 1993-97.
Member of the State of Michigan Public Health Department's "Radon Awareness"
Committee, 1993-94.
President, MSU-Sigma Xi Chapter, 1996-1997.
Recipient of award from MSU-Minority Medical Student Association, 1995.
Kenneth B. DuBois Award from Midwest Regional Chapter of Society of Toxicology,
1995.
Organized American Cancer Society symposium, Michigan Division, Nov. 17, 1995, MSU.
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Recipient of an Electric Power Research Institute Grant, 1996-1998.
Recipient of a competitive NCI grant, 1996-2000.
Recipient of an Electric Power Research Institute Grant, 2000-2001
Recipient of a gift from Loretta Van Camp Foundation for diabetes research, 1998-2000.
Scientific Achievement Award from Society of Toxicology, 2000.
Recipient of the Japan Society for the Promotion of Science Award, 2001.
Recipient of a McLaren Foundation Grant, 2001.
Recipient of an NIEHS Superfund grant, 2002.
Recipient of renewal of NIEHS Superfund grant, 2003.
Invited member of an International Consortium on “Low Level Radiation Effects” from
the University of Nagasaki, Japan, 2003.
Member of the Advisory Committee of the National Food Safety Toxicology Center,
Michigan State University, 2002-2003.
Organized the “Stem Cell Research and Therapeutics” symposium in San Diego, Ca, on
April 11-12, 2005
Became a consultant to the Princess Chulabhorn Research Institute in Bangkok,
Thailand.
Became a scientific consultant to the Radiation Effects Research Foundation, Hiroshima,
Japan, 2005.
Was recipient of Core Director, Superfund Grant, 2006-2011.
Helped to organize meeting on Gap Junctions on Disease Implications, Tokyo, Japan,
2006.
Received the Korean Ministry of Science & Technology “Brain Pool” award ( Aug. -Nov)
at Seoul National University, Seoul, Korea, 2006.
Was Visiting Scholar at ARNAS-Civico, Dept. of Oncology, Palermo, Sicily, March 1- Sept.
1, 2007.
Organized the superfund meeting on “ The NAS and WHO on Dioxin-like compounds:
International Implications and potential Impact”. Sept. 19th, 2007, Michigan State
University.
Receive patent , Non-Fiber Extract of psyllium with anti-tumorigenic effects and method
for identifying the same”,March 27th, 2007.
Helped University of Nagasaki get renewal grant from the Ministry of Education,
Culture, Sports, Scienceand technology. The new COE grant, whose title is "Global
Strategic Center for RadiationHealth Risk Control", 2007-2012.
Helped to Organize Conference, “Steroid Enzyme & Cancer”, Ettore Majorana Center for
Scientific Cultural, Erice, Sicily, May 3-8, 2008.
Help to organize the conference, “Health Effects of Low Level Radiation Exposure”,
Michigan State University, Sept. 30, 2008.
Received MSU grant, Nov. , 2008, $60,000.00 . Starts, Jan. 01, 2009- Dec. 31, 2010
Elected to the College of Human Medicine’s Graduate Studies Committee ( Aug, 162009- Aug. 15, 2011
RESEARCH ACTIVITIES
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Worked for Dr. L. L. Curry at Central Michigan University on two projects 1957-59.
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Institute for Fisheries Research (trout food studies).
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Radioisotope studies on aquatic midges, together with histological studies,
isotope distribution and detection techniques.
Summers of 1959 and 1960 at Argonne National Laboratory under Dr. Herman Slatis.
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Assisted Dr. Slatis in research on Drosophila larva (trachea-broken mutant),
longevity of progeny of irradiated mice, chromatographic study of amino acid patterns in
human urine.
Master's and Ph.D. research at Michigan State University under Dr. Armon F. Yanders,
1960-63.
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Master's thesis: "The effect of aging irradiated Drosophila sperm on the
sex-linked lethal rate and sex-ratio".
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Ph.D. thesis: "Analysis of post-irradiated modification of genetic damage in
mature Drosophila sperm".
Graduate research assistant at Michigan State University under Dr. Leroy Augenstine
during the summer of 1962.
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Assisted in research on the reactivation of ultraviolet-irradiated trypsin molecules.
This involved the study of the mechanism of repair of UV-damaged molecules.
Postdoctoral research at Oak Ridge National Laboratory under Dr. Sheldon Wolff, Dr.
Ernest Chu and Dr. Richard Setlow during Sept. 1963 - Oct. 1965.
Staff member at Oak Ridge National Laboratory in radiation-biophysics, Sept. 1965 Sept. 1966.
Spent Summer 1970 at Oak Ridge National Laboratory in mammalian cell mutagenesis
(Dr. E. Chu) and UV-biophysics (Dr. R.B. Setlow).
Teaching general education of science to undergraduates, doing research in ultraviolet
light biophysics on human cells and teaching medical students comprise my professional
duties at the present time.
Career Development Awardee from NIH working on the Molecular Basis for Genetic and
Environmental Influences on Mutagenesis and Carcinogenesis in Human Beings at
Michigan State University, 1972-77.
Cancer research in Dr. Van R. Potter's laboratory at the McArdle Laboratory for Cancer
Research in Madison, WI (DNA repair in mice, rats and human cells.
Research leave of absence to work in Dr. Ron Hart's laboratory at the Ohio State Cancer
Center, Columbus, OH (March-May, 1975).
Trainee in Molecular Biology, University of Colorado, Denver, CO, Summer 1989.
Research leave of absence to become Chief of Research, Radiation Effects Research
Foundation, Hiroshima, Japan (August 1990-92).
Spent three months at the Adult stem Cell Research Center, Seoul National University,
Seoul , Korea, Aug-Nov. , 2006.
Was Visiting Scholar at the Dept. of Oncology, ARNAS-Civico, Palermo, Sicily to isolate
human prostate stem cells
Estabolistic a “ General Agreement for Academic XXXXX” between the University of
Nagasaki and Michigan State University, 2007-20012.
PUBLICATIONS
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Trosko, J.E.: "Effect on genetic damage of posttreatments given x-rayed Drosophila
males”. Genetics 49:401-409, 1964.
Trosko, J.E., E. Chu, and W.L. Carrier: "The induction of thymine dimers in
ultraviolet-irradiated mammalian cells”. Rad. Res. 24: 667-672, 1965.
Trosko, J.E. and S. Wolff: "Strandedness of Vicia faba chromosome as revealed by
enzyme digestion studies". J. Cell Biol. 26:125-135, 1965.
Jacob, K. and J.E. Trosko: "The relation between 5-amino uracil-induced mitotic
synchronization and DNA synthesis". Exp. Cell Res. 40:56-67, 1965.
Trosko, J.E. and J.G. Brewen: "Cytological observations on the strandedness of
mammalian metaphase chromosomes". Cytologia 31:208-212, 1966.
Trosko, J.E. and M.R. Kasschau: "Study of pyrimidine dimers in mammalian cells
surviving low doses of ultraviolet radiation". Photochem. Photobiol. 6:215-219, 1967.
Muhammed, A., J. Concalves and J.E. Trosko: "Deoxyribonuclease and deoxyribonucleic
acid polymerase activity during Drosophila development". Develop. Biol. 15:23-32, 1967.
Regan, J., J.E. Trosko, and W.L. Carrier: "Evidence for excision of ultra- violet-induced
pyrimidine dimers from DNA of human cells in vitro". Biophysical J. 8:319-325, 1968.
Trosko, J.E. and V. Mansour: "Response to tobacco and Haplopappus cells to ultraviolet
irradiation after posttreatment with photoreactivating light". Rad. Res. 36:333-343,
1968.
Trosko, J.E. and L. Isaacs: "Some properties of radioactivity" and "Neuron Activation".
In: Laboratory Manual for Natural Science, Michigan State University Press, 1967.
Trosko, J.E. and V. Mansour: "Photoreactivation of ultraviolet light- induced pyrimidine
dimers in Ginkgo cells grown in vitro". Mut. Res. 7:120-121, 1969.
Rosenberg, B., L. VanCamp, J.E. Trosko and V. Mansour: "New class of potent
anti-tumor agents". Nature 222:385-386, 1969.
Cleaver, J.E. and J.E. Trosko: "DNA degradation products from mammalian cells
irradiated with ultraviolet light". Intern. J. Rad. Biol 15:411-424, 1969.
Trosko, J.E. and V.H. Mansour: "Photoreactivation of ultraviolet light- induced inhibition
of DNA synthesis in tobacco cells grown in vitro". Rad. Botany 9:523-525, 1969.
Cleaver, J.E. and J.E. Trosko: "Absence of excision of ultraviolet-induced cyclobutane
dimers in Xeroderma pigmentosum". Photochem. Photobiol. 11:547-550, 1970.
Trosko, J.E.: "Lack of photoreactivation in human cells grown in vitro". Intern. J. Rad.
Biol. 18:271, 1970.
Trosko, J.E. and M. Isoun: "Photosensitizing effect of Trisoralen on DNA synthesis in
human cells grown in vitro". Intern. J. Rad. Biol. 19:87, 1971.
Trosko, J.E. and J.G. Brewen: "Inhibition of UV-induced chromosome breaks by
cysteamine in 5-bromouracil-substituted mammalian cells". Rad. Res. 32:200-213,
1967.
Trosko, J.E. and M. Isoun: "Sunlight-induced pyrimidine dimers in human cells in vitro".
Nature 228:358, 1970.
Trosko, J.E.: Science as a Liberal study: "Is it worth a rose in a dung heap?"
Perspectives 1:62-68, 1970.
Trosko, J.E. and E.H.Y. Chu: "Effects of caffeine on the UV-induction of mutations in
Chinese hamster cells". Mutat. Res. 12:337-340, 1971.
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Trosko, J.E.: "Studies on DNA metabolism in human cells treated with LSD". Biochem.
Pharmacol. 20:3213-3218, 1971.
Trosko, J.E.: "General Education: A means to acquire meaning?" Report to Michigan
State University Ad Hoc Committee on General Education, Fall 1971.
Trosko, J.E.: "Abortion: A matter of human rights or human needs?" Position paper
prepared for U.S. Supreme Court, 1972.
Cleaver, J.E., G.H. Thomas, J.E. Trosko and J.T. Lett: "Excision repair (dimer excision,
strand breakage and repair replication) in primary cultures of eukaryotic (Bovine) cells".
Exp. Cell Res. 74:67-80, 1972.
Trosko, J.E. and H. Brody: "Children healthier if conceived when wind blowing from the
north: Aristotle". JAMA 222:1409-1410, 1972.
Trosko, J.E. and K. Wilder: "DNA repair mechanism in Drosophila melanogaster".
Genetics 73:297-302, 1973.
Trosko, J.E. and E.H.Y. Chu: "Inhibition of repair of UV-damaged DNA by caffeine and
mutation induction in Chinese hamster cells". Chem. Biol. Interact. 6:317-332, 1973.
Trosko, J.E., P. Frank, E.H.Y. Chu and J. Becker: "Caffeine-inhibition of post-replication
repair of N-acetoxy-2-acetylaminofluorene damaged DNA in Chinese hamster cells".
Cancer Res. 33:2444-2449, 1973.
Trosko, J.E. and J. Yager: "A sensitive method to measure physical and chemical
carcinogen-induced DNA synthesis in rapidly dividing eukaryotic cells. Exp. Cell Res.
88:47-55, 1974.
Brody, H., W. Weil, B. Miller and J. Trosko: "Integrating ethics into the medical
curriculum: One school's progress report". Michigan Med. 74:111-117, 1975.
Bowden, G.T., J.E. Trosko, B.G. Shapas and R.K. Boutwell: "Excision of pyrimidine
dimers from epidermal DNA and non-semiconservative epidermal DNA synthesis
following ultraviolet irradiation of mouse skin". Cancer Res. 35:3599-3607, 1975.
Trosko, J.E.: "Science as a focus for general education: A means to acquire meaning".
Biol. Human Affairs 39:12-20, 1973 (I); 39:38-45, 1974 (II).
Trosko, J.E. and E.H.Y. Chu: "The role of DNA repair and somatic mutation in
carcinogenesis". Adv. Cancer Res. 321:391-425, 1975.
Goodman, J., J.E. Trosko and J.D. Yager: "Studies on the mechanism of inhibition of
1-acetylaminofluorene toxicity by butylated hydroxytoluene". Chem.-Biol. Interact.
12:171-182, 1976.
Trosko, J.E., C.C. Chang, L.P. Yotti and E.H.Y. Chu: "Effect of phorbol myristate acetate
on the recovery of spontaneous and ultra-violet light- induced 6-thioguanine and
ouabain-resistant Chinese hamster cells". Cancer Res. 37:188-193, 1977.
Trosko, J.E., C.C. Chang and T. Glover: "Analysis of experimental evidence of the
relation between mutagenesis and carcinogenesis: The role of DNA in carcinogenesis".
In: Mechanismes d'Alteration et de Reparation du DNA, Relations avec la Mutagenesis
Chimique, Centre National de la Recherche Scientifique, Paris, 1977, pp. 353-388.
Trosko, J.E., J.D. Yager and G.T. Bowden: "The effect of several croton oil derivatives
on two types of DNA repair and cyclic nucleotides in mammalian cells in vitro".
Chem.-Biol. Interact 11:191-205, 1975.
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Weichsel, M.E. and J.E. Trosko: "In vivo reversal of thyroxine induction of DNA
synthesis in dibutyryl cyclic AMP in developing rat cerebellum". J. Neuro. Sci. 28:77-82,
1976.
Trosko, J.E.: "On making humane human beings in a `garbage in-garbage out' system".
Interdisciplina 1:1-25, 1976.
Trosko, J.E. and R. Hart: "DNA mutation frequencies in mammals". Interdisc. Topics
Geront. 9:168-197, Karger, Basel, 1976.
Hart, R. and J.E. Trosko: "DNA repair processes in mammals". Interdisc. Topics Geront.
9:134-167, Karger, Basel, 1976.
Trosko, J.E. and C.C. Chang: "The role of DNA repair in mutation and cancer
production". In: Aging, Carcinogenesis and Radiation Biology, Plenum Press, (ed. K.
Smith), NY, 1976, pp. 399-442.
Chang, C.C., C. Phillips, J.E. Trosko and R.W. Hart: "Mutagenic and epigenetic influence
of caffeine on the frequencies of UV-induced ouabain- resistant Chinese hamster cells".
Mutat. Res. 45:125-136, 1977.
Trosko, J.E.: "Bioethics: A philosophical basis for moral decisions". Ecologos 22:1-7,
1976.
Schmickel, R.D., E.H.Y. Chu, J.E. Trosko and C.C. Chang: "Cockayne syndrome: A
cellular sensitivity to ultraviolet light". Pediatrics 60:135-139, 1977.
Chu, E.H.Y., J.E. Trosko and C.C. Chang: "Mutational approaches to the study of
carcinogenesis". J. Toxicol. Environ. Health. 2:1317-1334, 1977.
Chang, C.C., S. D'Ambrosio, R. Schultz, J.E. Trosko and R.B. Setlow: "Modification of
UV-induced mutation frequencies in Chinese hamster cells by dose fractionation,
cycloheximide and caffeine treatments". Mutat. Res. 52:231-245, 1978.
Chang, C.C., J.E. Trosko and T. Akera: "Characterization of UV-light induced
ouabain-resistant mutations in Chinese hamster cells". Mutat. Res. 51:85-98, 1978.
Chang, C.C., J.E. Trosko and S.T. Warren: "In vitro assay for tumor promoters and
anti-promoters". J. Environ. Path. Toxicol. 2:43-64, 1978.
Trosko, J.E. and C.C. Chang: "Genes and environmental factors in carcinogenesis: An
integrative theory". Quart. Rev. Biol. 53:115-141, 1978.
Trosko, J.E. and C.C. Chang: "Chemical modification of radiation-induced mutagenesis
and its role in carcinogenesis". In: DNA Repair Mechanisms, (ed. E. Friedberg and P.
Hanawalt), Academic Press, NY, pp. 713-716, 1978.
Trosko, J.E. and C.C. Chang: "Relationship between mutagenesis and carcinogenesis".
Photochem. Photobiol. 28:157-168, 1978.
Trosko, J.E. and C.C. Chang: "The role of mutagenesis in carcinogenesis". In:
Photochem. Photobiol. Rev., Vol. 3, (ed. K.C. Smith), Plenum Press, pp. 135-165, 1978.
Yotti, L.P., J.E. Trosko and C.C. Chang: "Elimination of metabolic cooperation in Chinese
hamster cells by a tumor promoter". Science 206:1089-1091, 1979.
Yotti, L., T. Glover and J.E. Trosko: "Induction of x-ray induced HG-PRT mutations in
normal and Downs syndrome fibroblasts". Peds. Res. 14:88-92, 1980.
Schultz, R., C.C. Chang and J.E. Trosko: "Isolation and partial characterization of
mutagen-sensitive and DNA repair mutants of Chinese hamster cells". Environ.
Mutagen. 3:53-64, 1981.
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Trosko, J.E. and C.C. Chang: "Genes, environmental pollutants, mutations and human
diseases". Quart. Rev. Biophys. 4:603-627, 1978.
Chang, C.C., M. Castellazzi, T. Glover and J.E. Trosko: "Effects of harman and
norharman on spontaneous and UV light-induced mutagenesis in cultured Chinese
hamster cells". Cancer Res. 38:4525-4531, 1978.
Glover, T.W., C.C. Chang, J.E. Trosko and S.S.L. Li: "Ultraviolet light induction of
diphtheria toxin resistant-mutations in normal and xeroderma pigmentosum human
fibroblasts". Proc. Natl. Acad. Science 76:3982-3986, 1979.
Trosko J.E. and C.C. Chang: "The role of radiation and chemicals in the induction of
mutations and epigenetic changes during carcinogenesis". In: Advances in
Radiobiology, Vol. 9 (J. Lett and H. Adler, eds.), Academic Press, 1-36, 1981.
Trosko, J.E., R.A. Schultz, C.C. Chang and T. Glover: "Ultraviolet light induction of
diphtheria toxin-resistant mutations in normal and DNA repair- deficient human and
Chinese hamster fibroblasts". In: DNA Repair and Mutagenesis in Eukaryotes, (N.
Generoso, M. Shelby and F.J. deSerres, eds.) Plenum Press, NY, 1979, pp. 323-341.
Schultz, R., C.C. Chang and J.E. Trosko: The mutation studies of Mutagen- sensitive and
DNA repair mutants of Chinese hamster fibroblasts". Environ. Mutagen. 3:141-150,
1981.
Trosko, J.E., L.P. Yotti, B. Dawson and C.C. Chang: "In vitro assay for tumor
promoters". In: Short-Term Tests for Chemical Carcinogens, (H. Stich and R.H.C. San,
eds.), Springer-Verlag, NY, 1981, pp. 420-427.
Trosko, J.E. and C.C. Chang: "The role of DNA repair capacity and somatic mutations in
carcinogenesis and aging". In: Handbook of the Diseases of Aging: A Pathogenic
Perspective, (H.T. Blumenthal, ed.), Van Nostrand Reinhold Co., l983, pp. 252-295.
Trosko, J.E., B. Dawson, L.P. Yotti, and C.C. Chang: "Saccharin may act as a tumor
promoter by inhibiting metabolic cooperation between cells". Nature 285:109-110,
1980.
Trosko, J.E., L.P. Yotti, S.T. Warren and C.C. Chang: "In vitro detection of potential
tumor promoters". In: Short-Term Tests for Prescreening of Potential Carcinogens, (L.
Santi and S. Parodi, eds.), Instituto Scientifico per lo studio e la Cura dei Tumori,
Genora, 1979, pp. 45-53.
Tsushimoto, G., J.E. Trosko, C.C. Chang and F. Matsumura: "Cytotoxic, mutagenic and
tumor promoting properties of DDT, Lindane and Chlordane on Chinese hamster cells in
vitro". Arch. Env. Cont. Toxicol. 12:721-730, 1983.
Moskal, J.R., M.W. Lockney, C.C. Marvel, P.A. Mason, S.T. Warren, J.E. Trosko and C.C.
Sweeley: "Regulation of glycoconjugate metabolism in normal and transformed cells".
In: Cell Surface Glycolipids, (C.C. Sweeley, ed.). ACS Symposium Series, Washington,
DC, pp. 241-263, 1980.
Trosko, J.E., B. Dawson, and C.C. Chang: "PBB inhibits metabolic cooperation in
Chinese hamster cells in vitro: Its potential as a tumor promoter". Environ. Health.
Perspect. 37:179-182, 1981.
Trosko, J.E. and C.C. Chang: "An integrative hypothesis linking cancer, diabetes and
atherosclerosis: The role of mutations and epigenetic changes". Med. Hypoth.
6:455-468, 1980.
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Trosko, J.E. and C.C. Chang: "Mutations and gene modulators: Mechanisms and
potential consequences to human health". In: National Academy of Sciences Report on
Indoor Pollutants, National Academy Press, Wash., DC, 1981.
Horrobin, D.F. and J.E. Trosko: "The possible effect of diazepam on cancer
development and growth". Med. Hypoth. 7:133-143, 1981.
Trosko, J.E. and D.F. Horrobin: "The activity of diazepam in a Chinese hamster V79 lung
cell assay for tumor promoters". IRCS J. Med. Sci. Biochem. 8:887, 1980.
Warren, S., R.A. Schultz, C.C. Chang, M.H. Wade and J.E. Trosko: "Elevated
spontaneous mutation rate in Bloom syndrome fibroblasts". Proc. Natl. Acad. Science
USA 78:3133-3137, 1981.
Slaga, T.J., A.S.P. Klein-Szanto, L.C. Triplett, L.P. Yotti, J.E. Trosko: "Skin tumor
promoting activity of benzoyl peroxide: A widely used free radical generating
compound". Science 213:1023-1025, 1981.
Chang, C.C., M. Castellazzi and J.E. Trosko: "Effect of temperature and exogenous
dibutyrl c-AMP on the recovery of UV-induced ouabain-resistant Chinese hamster cells".
Mutat. Res. 91:81-86, 1981.
Trosko, J.E. and C.C. Chang: "Chemical carcinogenesis as a consequence of alterations
in the structure and function of DNA". In: Chemical Carcinogenesis and DNA. Vol. 2, p.
181-200, (P.L. Grover, ed), CRC Press, Boca Raton, FL, 1979.
Warren, S.T., L.P. Yotti, J.R. Moskal, C.C. Chang and J.E. Trosko: "Metabolic
cooperation in CHO and V79 cells following treatment with a tumor promoter". Exp. Cell
Res. 131:427-430, 1981.
Trosko, J.E.: "Cancer Causation". Correspondence, Nature 290:356, 1981.
Warren, S.T., D.J. Doolittle, C.C. Chang, J.I. Goodman and J.E. Trosko: "Evaluation of
the carcinogenic potential of 2,4-dinitrofluorobenzene and its implications regarding
mutagenicity testing". Carcinogenesis 3: 139-145, 1982.
Sabourin, C.L.K., P.F. Bates, L. Glatzer, C.C. Chang, J.E. Trosko and J.A. Boezi:
"Selection of aphidicolin-resistant CHO cells with altered levels of ribonucleotide
reductase". Som. Cell Genet. 7:255-268, 1981.
Chang, C.C., J.A. Boezi, S.T. Warren, C.L.K. Sabourin, P.K. Liu, L. Glatzer and J.E.
Trosko: "Isolation and characterization of a UV-sensitive hypermutable
aphidicolin-resistant Chinese hamster cell line". Som. Cell Genetics 7:235-253, 1981.
Trosko, J.E. and C.C. Chang: "Potential role of mutagenic and epigenetic mechanisms in
aplastic anemia and leukemia". In: Proceedings of the Conference on Aplastic Anemia:
A Stem Cell Disease, (A.S. Levine, ed.), U.S. Dept. of Health and Human Services, pp.
255-265, 1981.
Tsushimoto, G., J.E. Trosko, C.C. Chang and S.D. Aust: "Inhibition of metabolic
cooperation in Chinese hamster V79 cells in culture by various polybrominated biphenyl
(PBB) congeners". Carcinogenesis 3:181-185, 1982.
Trosko, J.E., C.C. Chang and M. Netzloff: "The role of inhibited cell-cell communication
in teratogenesis". Teratogenesis, Carcinogenesis, Mutagenesis 2:31-45, 1982.
Trosko, J.E., C.C. Chang, S.T. Warren, P.K. Liu, M.H. Wade and G. Tsushimoto: "The
use of mammalian cell mutants to study the mechanisms of carcinogenesis". GANN
27:159-179, 1981.
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Tsushimoto, G., J.E. Trosko, C.C. Chang and F. Matsumura: "Inhibition of intercellular
communication by chlordecone (Kepone) and mirex in Chinese hamster V79 cells in
vitro". TAP 64:550-556, 1982.
Bruczak, J.D., J.R. Moskal, J.E. Trosko and C.C. Sweeley: "Phorbol ester associated
changed in cell growth and total cellular glycosphingolipids". Exp. Cell Res.
147:281-286, 1983.
Jensen, R.K., S.D. Sleight, J.I. Goodman, S.D Aust. and J.E. Trosko: "Polybrominated
biphenyls as promoters in experimental hepatocarcinogenesis in rats". Carcinogenesis
3:1183-1186, 1982.
Jone, C.M., J.E. Trosko, C.C. Chang, H. Fujiki, and T. Sugimura: "Inhibition of
intercellular communication in Chinese hamster V79 cells by teleocidin". GANN
73:874-878, 1982.
Madhukar, B.V., M. Yoneyama, F. Matsumura, J.E. Trosko and G. Tsushimoto:
"Alteration of calcium transport by tumor promoters TPA and DDT in the Chinese
hamster V79 cell line". Cancer Lett. 18:251-259, 1983.
Huang, Y., C.C. Chang and J.E. Trosko: "Aphidicolin induces endoreduplication in
Chinese hamster cells". Cancer Res. 43:1361-1364, 1983.
Yancey, S.B., J.E. Edens, J.E. Trosko, C.C. Chang and J-P. Revel: "Decreased incidence
of gap junctions between Chinese hamster V79 cells upon exposure to the tumor
promoter TPA". Exp. Cell Res. 139:329-340, 1982.
Tsushimoto, G., S. Asano, J.E. Trosko and C.C. Chang: "Inhibition of intercellular
communication by various congeners of polybrominated biphenyl and polychlorinated
biphenyl. In: PCB's: Human and Environmental Hazards, (M. Kamrin and F. D'Itri,
eds.), Butterworth Publ., Boston, MA, 1983, pp. 241-252.
Trosko, J.E., V.M. Riccardi, C.C. Chang, S.T. Warren and M.H. Wade: "Genetic
predispositions to initiation or promotion phases in human carcinogenesis". In:
Genetics, Biomarkers, and Cancer, (H.T. Lynch and H.A. Guirgis, eds.), Van Nostrand
Reinhold Press, N.Y., pp. 13-37, 1985.
Liu, P.K., C.C. Chang and J.E. Trosko: "Association of mutator activity with
UV-sensitivity in an aphidicolin-resistant mutant of Chinese hamster V79 cells. Mutat.
Res. 106:317-332, 1982.
Liu, P.K., J.E. Trosko and C.C. Chang: "Hypermutability of a UV-sensitive
aphidicolin-resistant mutant of Chinese hamster fibroblasts". Mutat. Res. 106:333-345,
1982.
Trosko, J.E. and C.C. Chang: "Implications of genotoxic and non-genotoxic mechanisms
in carcinogenesis to risk assessment". In: Methods for Estimating Risk of Chemical
Injury: Human and Non-Human Biota and Exosystems, V.B. Vouk, G.C. Butler, D.G.
Hoel, and D.B. Peakall, eds., John Wiley and Sons, NY, pp.181-200, 1985.
Trosko, J.E. and C.C. Chang: "Potential role of intercellular communication in the
rate-limiting step in carcinogenesis". J. Amer. Coll. Toxicol. 2:5-22, 1983.
Trosko, J.E. and C.C. Chang: "Role of intercellular communication in tumor promotion".
In: Tumor Promotion and Cocarcinogenesis In Vitro, Vol. IV, (T.J. Slaga, ed.), CRC
Press, Boca Raton, FL, pp. 119-145, 1984.
Trosko, J.E., L.P. Yotti, S.T. Warren, G. Tsushimoto and C.C. Chang: "Inhibition of
cell-cell communication by tumor promoters. In: Carcinogenesis, Vol 7, pp. 565-585,
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(Ed. Hecker, N.E. Fusinig, W. Kunz, F. Marks, and H.W. Thielmann, eds.), Raven Press,
NY, 1982.
Trosko, J.E.: "Potential role of mutations and inhibited intercellular communication in
the genesis of some chronic diseases". J. Environ. Sci. Health. A17(4):605-608, 1982.
Liu, P.K., C.C. Chang, J.E. Trosko, D.K. Dube, G.M. Martin and L.A. Loeb: "Mammalian
mutator mutant with an aphidicolin-resistant DNA polymerase alpha". Proc. Natl. Acad.
Science USA 80:797-801, 1983.
Aylsworth, C.F., C. Jone, J.E. Trosko, J. Meites and C.W. Welsch: "Promotion of 7,12dimethylbenz(a)anthracene-induced mammary tumorigenesis by high dietary fat in the
rat: Possible role of intercellular communication". J. Natl. Cancer Instit. 72:637-745,
1984.
Trosko, J.E. and C.C. Chang: "Error-prone DNA repair and replication in relation to
malignant transformation". Transplantation Proc. 16:363-365, 1984.
Trosko, J.E. “Scientific views of human nature: Implications for the ethics of technological
intervention”. In: The Culture of Biomedicine. Vol. 1. D. H. Brock, ed., University of
Delaware Press, Newark, pp. 70-97, 1984.
Wade, M.H. and J.E. Trosko: "Enhanced survival and decreased mutation frequency
after photoreactivation of UV damage in rat kangaroo cells. Mutat. Res. 112:231-243,
1983.
Trosko, J.E. and C.C. Chang: "A possible mechanistic link between teratogenesis and
carcinogenesis: Inhibited intercellular communication". In: Principles of Environmental
Mutagenesis, Carcinogenesis and Teratogenesis, (E.H.Y. Chu, A. Hollaender and W.
Generoso, eds.), Plenum Press, pp. 529-547, 1984
Trosko, J.E., C.C. Chang and A. Medcalf: "Mechanisms of tumor promotion: Potential
role of intercellular communication". Cancer. Invest. l (6):511-526, 1983.
Trosko, J.E., C. Jone, C.C. Chang: The role of tumor promoters on phenotypic
alterations affecting intercellular communication and tumorigenesis. Ann. N. Y. Sci.
407:316-327, 1983.
Jensen, R.K., S.D. Sleight, S.D. Aust, J.I. Goodman and J.E. Trosko: "Hepatic
tumor-promoting ability of 3,3',4,4',5,5'-hexabromobiphenyl: The interrelationship
between toxicity, induction of hepatic microsomal drug metabolizing enzymes and
tumor-promoting ability". TAP 71:163-176, 1983.
Trosko, J.E., C. Jone, C. Aylsworth and C.C. Chang: In vitro assay to detect inhibitors of
intercellular communication". In: Handbook of Carcinogen Testing, (H.A. Milman and
E.K. Weisburger, eds.), Noyes Publ., NJ, p. 422-437, 1985.
Trosko, J.E., C. Jone and C.C. Chang: "The use of in vitro assays to study and to detect
tumor promoters". In: Models, Mechanisms and Etiology of Tumor Promotion, (M.
Borzsonyi, K. Lapid. N. Day, H. Yamasaki, eds.), International Agency for Research on
Cancer Scientific Publication, Lyon, France, 1984, pp. 239-252.
Liu, P.K., C.C. Chang and J.E. Trosko: "Evidence of a mutagenic repair in a Chinese
hamster cell mutant with aphidicolin-resistant DNA polymerase alpha". Somatic Cell
Genetics 10:235-245, 1984.
Trosko, J.E. and C.C. Chang: "Adaptive and non-adaptive consequences of intercellular
communication". Pharmacol. Rev. 36:137s-144s, 1984.
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126.
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130.
131.
Trosko, J.E., C. Jone and C.C. Chang: "Oncogenes, inhibited intercellular communication
and tumor promotion". In: Cellular Interactions by Environmental Tumor Promoters, H.
Fujiki, E. Hecker, R.E. Moore, T. Sugimura and I.B. Weinstein, eds., Japan Sci. Press,
Tokyo, pp. 101-113, 1984.
Loch Caruso, R., J.E. Trosko and I.A. Corcos: "Interruption of cell-cell communication in
Chinese hamster V79 cells by various alkyl glycol ethers: Implications for
teratogenicity". Envir. Health Perspect. 57:119-123, 1984.
Trosko, J.E., C.M. Jone, R.A. Rintel and C.C. Chang: "Potential role of calmodulin in
tumor promotion: Modulator of gap junctional intercellular communication". In:
Calmodulin Antagonists and Cellular Physiology, (H. Hidaka and D.J. Hartshorne, eds.),
Academic Press, NY, 1985.
Trosko, J.E., C.C. Chang, M.H. Wade: "Mammalian Mutagenesis". In: Genetics: New
Frontiers, Oxford and IBH Publ., New Delhi, pp. 329-346, 1984.
Jone, C.M., J.E. Trosko and L. Parker: "Further characterization of the Chinese hamster
V79 metabolic cooperation assay", Carcinogenesis 6:361-366, 1985.
Trosko, J.E., C. Aylsworth, C.M. Jone and C.C. Chang: "Possible involvement of
arachidonate products in tumor promoter inhibition of cell-cell communication". In:
Prostaglandins and Tumor Promotion, (T. Slaga and S. Fisher, eds.), M. Nijhoff, Boston,
pp. 169-197, 1985.
Trosko, J.E.: "Intercellular Communication", Oncology Overview, PB84- 923005, Sept.,
1984.
Jone, C.M., L. Parker, J.E. Trosko, M. Netzloff and C.C. Chang: "Inhibition of metabolic
cooperation by the anticonvulsants, diphenylhydantoin and phenobarbital",
Teratogenesis, Carcinogenesis and Mutagenesis 5:379-391, 1985.
Chen, T.H., T. Kavanagh, C.C. Chang and J.E. Trosko: "Inhibition of metabolic
cooperation in Chinese hamster V79 cells by various organic solvents and simple
compounds". Cell Biol. Toxicol. 1:155-171, 1984.
Trosko, J.E. and C.C. Chang: "Role of tumor promotion in affecting the multi-step
nature of carcinogenesis". In: Assessment of Risk from Low Level Exposure to Radiation
and Chemicals, (A.D. Woodhead, C.J. Shellabarger, V. Pond, A. Hollaender, eds.), p.
261-284, 1985. Plenum Press, NY.
Schwartz, K.A., G. Lu, J.E. Trosko and C.C. Chang: "Serum from outdated human
platelet concentrates: An alternative supplement for tissue (fibroblast) culture" Amer. J.
Hemat. 17:2327, l984.
Rubinstein, C., C. Jone, J.E. Trosko and C.C. Chang: "Inhibition of intercellular
communication in cultures of Chinese hamster V79 cells by 2,4-D and 2,4,5-T". Fund.
Appl. Toxicol. 4:731-739, 1984.
Dube, D.K., R. Loch-Caruso, J.E. Trosko, I. Chakravarty, A. Ghosh and L.A. Loeb:
"Assessment of the carcinogenic potential of a proposed food coloring additive, laccaic
acid, using short-term assays". Cell Biol. Toxicol. 1:111-125, 1984.
Loch-Caruso, R. and J.E. Trosko: "Inhibited intercellular communication as a
mechanistic link between teratogenesis and carcinogenesis". CRC Critical Reviews in
Toxicol. 16:l57-l83, l985.
Malcolm, A.R., L.J. Mills and J.E. Trosko: "Effects of ethanol, phenol, formaldehyde and
selected metabolites on metabolic cooperation between Chinese hamster V79 lung
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fibroblasts". In: Cancer of the Respiratory Tract: Predisposing Factors, Vol. 8, M.J.
Mass, J.M. Siegfried, D.G. Kaufman, V.E. Steele, S. Newman (eds.), Raven Press, NY,
pp. 305-318, 1985.
Chang, C.C., J.E. Trosko, H-J Kung, D. Bombick and F. Matsumura: "Potential role of the
src gene product in inhibition of gap-junctional communication in NIH-3T3 cells. Proc.
Natl. Acad. Sci. USA 82:5360-5364, 1985.
Trosko, J.E., C.M. Jone and C.C. Chang: "The role of intercellular communication in the
evaluation of in vitro/in vivo toxicity testing of chemicals". In: Proc. 15th Ann. Conf.
Environ. Toxicology, AFAMRL-TR-84- 002, Univ. of California, Irvine, CA, pp. 167-191,
1985.
Kavanagh, T.J., C. Rubinstein, P.K. Liu, C.C. Chang, J.E. Trosko and S.D. Sleight:
"Failure to induce mutations in Chinese hamster V79 cells and WB rat liver cells by
PBB's, Firemaster BP-6, 2,2',4,4',5,5'- hexabromobiphenyl, 3,3',4,4',5,5'hexabromobiphenyl and 3,3',4,4'- tetrabromobiphenyl. Toxicol. Appl. Pharmacol.
79:91-98, 1985.
Kavanagh, T.J., C.C. Chang and J.E. Trosko: "Characterization of a human
teratocarcinoma cell assay for inhibitors of metabolic cooperation". Cancer Res.
46:l359-l366, 1986.
Schindler, M., J.E. Trosko and M.H. Wade: "Fluorescence photobleaching assay of TPA
inhibition of cell-cell communication". In: Methods of Enzymology Cellular Regulators,
Part B. Calcium and Lipids, Vol. 141:439-447, 1987.
Lin, Z.-X., T. Kavanagh, J.E. Trosko and C.C. Chang: Inhibition of gap- junctional
communication in human teratocarcinoma cells by organochlorine pesticides. Toxicol.
Appl. Pharm. 83:10-19, 1986.
Wade, M.H., J.E. Trosko and M. Schindler: A fluorescence photobleaching assay of gap
junction mediated cell-cell communication in human cells. Science 232:525-528, 1986.
Trosko, J.E. and C.C. Chang: Oncogene and chemical inhibition of gap- junctional
intercellular communication: Implications for teratogenesis and carcinogenesis. In:
Genetic Toxicology of Environmental Chemicals. Part B. Genetic Effects and Applied
Mutagenesis, (C. Ramel, B. Lambert, J. Magnusson, Eds.). Alan R. Liss, Inc., New York,
pp. 21-31, 1986.
Aylsworth, C.F., J.E. Trosko and C.W. Welsch: Influence of lipids on gap
junction-mediated intercellular communication between Chinese hamster cells in vitro.
Cancer Res. 46:4527-4533, 1986.
Trosko, J.E., C. Jone and C.C. Chang: Inhibition of gap junctional- mediated intercellular
communication, in vitro, by aldrin dieldrin and toxaphene: A possible cellular
mechanism for their tumor-promoting and neurotoxic effects. Molec. Toxicol. 1:83-93,
1987.
El-Fouly, M.H., J.E. Trosko and C.C. Chang: "Scrape-loading and dye transfer: A rapid
and simple technique to study gap junctional intercellular communication”. Exp. Cell
Res. 168:422-430, 1987.
Trosko, J.E.: "Mechanisms of tumor promotion: Possible role of inhibited intercellular
communication”. European J. Cancer Clin. Oncology 23:599-601, 1987.
14
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148.
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150.
151.
152.
153.
154.
155.
156.
Chang, C.C., R.E. Gibson-D'Ambrosio, J.E. Trosko and S.M. D'Ambrosio: "Growthpromoting effects of TPA on cultured normal human fetal kidney epithelial cells". Cancer
Res. 46:6360-6363, 1986.
Trosko, J.E. and C.C. Chang: "Role of intercellular communication in modifying the
consequences of mutations in somatic cells”. In: Antimutagenesis and
Anticarcinogenesis Mechanisms. D.M. Shankel, P.E. Hartman, T. Kada and A.
Hollaender, eds., Plenum Pub., New York, pp. 439-456, 1986.
Trosko, J.E. and C.C. Chang: "Oncogene and chemical inhibition of gap- junctional
intercellular communication: Implications for teratogenesis and carcinogenesis. In:
Genetic Toxicology of Environmental Chemicals. Part B, pp. 21-31, Alan R. Liss, Inc.,
New York, 1986.
Kavanagh, T.J., C.C. Chang and J.E. Trosko: "Effect of various polybrominated
biphenyls on cell-cell communication in cultured human teratocarcinoma cells. Fund.
Appl. Toxicol. 8:127-131, 1987.
Schindler, M., Trosko, J.e., Wade, M. H., “ Fluorescence photobleaching assay of tumor
promoter 12-0-tetradecanoylphorbol 13-acetate inhibition of cell-cell communication”.
Methods in Enzymology 141: 439-447, 1987.
Moskal, J.R., M.W. Lockney, C.C. Marvel, J.E. Trosko and C.C. Sweeley: "Effect of
retinoic acid and phorbol-12-myristate-13-acetate on glycosyltransferase activities in
normal and transformed cells. Cancer Res. 47:787-790, 1987.
Jone, C., J.E. Trosko and C.C. Chang: "Characterization of a rat liver epithelial cell line
to detected inhibitors of metabolic cooperation”. In Vitro Cellular and Developmental
Biol. 23:214-220, 1987
Jone, C., L. Erickson, J.E. Trosko and C.C. Chang: "Effect of biological toxins on
gap-junctional intercellular communication in Chinese hamster V79 cells”. Cell Biol.
Toxicol. 3:1-5, 1987.
Aylsworth, C.F., C.W. Welsch, J.J. Kabara and J.E. Trosko: "Effects of fatty acids on gap
junctional communication: Possible role in tumor promotion by dietary fat”. Lipids
22:445-454, 1987.
Barrett, J.C., T. Kakunaga, T. Kuroki, D. Neubert, J.E. Trosko, J.M. Vasiliev, G.M.
Williams and H. Yamasaki: "In vitro assays that may be predictive ot tumor-promoting
agents. In: Long-Term and Short-Term Assays for Carcinogens. R. Montesano, H.
Bartsch, H. Vainio, J. Wilbourn and H. Yamasaki, IARC Sci. Pub., #83, 1986, Lyon
France.
Jongen, W.F.F., B.J.N. VanderLeede, C.C. Chang and J.E. Trosko: "The transport of
reactive intermediates in a co-cultivation system: The role of intercellular
communication". Carcinogenesis 8:1239-1243, 1987.
Mori, T., CC. Chang and J.E. Trosko: "The role of the inhibition of DNA polymerase
alpha by aphidicolin in DNA amplification in Chinese hamster V79 cells". In:
Accomplishments in Oncology, Vol. 2, pp. 161-172, H. zurHausen and J.R. Schlehofer,
eds., J.B. Lippincott Company, Philadelphia, 1987.
Kavanagh, T., G.M. Martin, M. El-Fouly, J.E. Trosko, C.C. Chang and P.S. Rabinovitch:
"Flow cytometery and scrape-loading/dye transfer as a rapid quantitative measure of
intercellular communication in vitro". Cancer Res. 47:6046-6051, 1987.
15
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163.
164.
165.
166.
167.
168.
169.
Suter, S., J.E. Trosko, M.H. El-Fouly, L.R. Lockwood and A. Koestner: "Dieldrin inhibition
of gap junctional intercellular communication in rat glial cells as measured by the
fluorescence-photobleaching and scrape loading/dye trasnfer assays". Fund. Appl.
Toxicol. 9:785-794, 1987.
Trosko, J.E., C.C. Chang and B.V. Madhukar: "Chemical and oncogene modulation of
intercellular communication in tumor promotion. In: Advances in Modern
Environmental Toxicology, Vol. XIV, Biochemical Mechanisms and Regulation of
Intercellular Communication. H.A. Milman and E. Elmore, eds., Princeton Scientific
Publishing Co., Inc., Princeton, NJ. pp. 209-236, 1987.
Chang, C.C., J.E. Trosko, M.H. El-Fouly, R.E. Gibson-D'Ambrosio and S.M. D'Ambrosio:
"Contact insensitivity of a subpopulation of normal human fetal kidney epithelial cells
and of human carcinoma cell lines". Cancer Res. 47:1634-1645, 1987.
Evans, M.G. and J.E. Trosko: "Anchored cell analysis/sorting coupled with the
scrape-loading/dye trasnfer technique to quantity inhibition of gap junctional intercellular
communication in WB-F344 cells by 2,2',4,4',5,5'- hexabromobiphenyl". J. Toxicol.
Environ. Health 24:261-271, 1988.
Evans, M.G. and J.E. Trosko: "Concentration/response effect of
2,2',4,4',5,5'-hexabromobiphenyl on cell-cell communication in vitro: Assessment by
fluorescence redistribution after photobleaching (FRAP)". Cell Biol. Toxicol. 4:163-171,
1988.
Chang, C.C., C. Jone, J.E. Trosko, A.R. Peterson and A. Sevanian: "Effect of Cholesterol
epoxides on the inhibition of intercellular communication and on mutation induction in
Chinese hamster V79 cells". Mut. Res. 206:471-478, 1988.
Peterson, A.R., A. Peterson, C.P. Spears, J.E. Trosko and A. Sevanian: "Mutagenic
characterization of cholesterol epoxides in Chinese hamster V79 cells”. Mutation Res.
203:355-366, 1988.
Trosko, J.E.: "A failed paradigm: Carcinogenesis is more than mutagenesis".
Mutagenesis 3:363-366, 1988.
Rezabek, M.S., J.E. Trosko, C. Jone and S.D. Sleight: "Effects of hepatic tumor
promoters phenobarbital and polybrominated biphenyls on intercellular communication
between rat liver epithelial cells". In Vitro Toxicology 2:43-58, 1988.
Nicolson, G.L., K.M. Dulski and J.E. Trosko: "Loss of intercellular junctional
communication correlates with metastatic potential in mammary adenocarcinoma cells.
Proc. Natl. Acad. Sci. 85:473-476, 1988.
Trosko, J.E., C.C. Chang, B.V. Madhukar, S.Y. Oh, D. Bombick and M.H. El-Fouly:
"Modulation of gap junction intercellular communication by tumor promoting chemicals,
oncogenes and growth factors during carcinogenesis". In: Modern Cell Biology, Vol. 7:
Gap Junctions, E.L. Hertzberg and R.G. Johnson, eds., Alan R. Liss, Inc., New York, pp.
435-448, 1988.
Nicolson, G.L., R.B. Lichtner and J.E. Trosko: "Cytoskeletal and junctional heterogenity in
mammary and tumor cells and their possible significance in tumor progression". In:
Cancer Metastasis. G. Prodi, L.A. Liotta, P.L. Lollini, S. Garbisa, S. Gorini and K. Hellman,
eds., Plenum Publishing, New York, pp. 21-26, 1988.
Oh, S.Y., B.V. Madhukar, J.E. Trosko: "Inhibition of gap junctional blockage by palmitoyl
carnitine and TMB-8 in a rat liver epithelial cell line. Carcinogenesis 9:135-139, 1988.
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Trosko, J.E. and C.C. Chang: "Chemical and oncogene modulation of gap junction
intercellular communication". In: Tumor Promoters: Biological Approaches for
Mechanistic Studies and Assay Systems. R. Langenbach et al., (eds.), Raven Press, NY,
pp. 97-111, 1988.
Trosko, J.E. and C.C. Chang: "Nongenotoxic mechanisms in carcinogenesis: Role of
inhibited intercellular communication". In: Banbury Report 31: New Directions in the
Qualitative and Quantitative Aspects of Carcinogen Risk Assessment, R. Hart and F.D.
Hoerger, eds., Cold Spring Harbor Press, Cold Spring Harbor, NY, pp. 139-170, 1989.
Trosko, J.E. and C.C. Chang: "The role of inhibited intercellular communication in
carcinogenesis: Implications for risk assessment from exposure to chemicals". In:
Biologically Based Methods for Cancer Risk Assessment. C.C. Travis, Ed., Plenum Press,
NY, pp. 165-179, 1989.
Aylsworth, C.F., J.E. Trosko, C.C. Chang, K. Benjamin and E. Lockwood: "Synergistic
inhibition of metabolic cooperation by oleic acid or TPA and DDT in Chinese hamster V79
cells: Implications of a role for protein kinase C in the regulation of gap junctional
intercellular communication. Cell Biol.Toxicol. 5:27-37, 1989.
Madhukar, B.V., S.Y. Oh, C.C. Chang, M. Wade and J.E. Trosko: "Altered regulation of
intercellular communication by epidermal growth factor, transforming growth factor-B
and peptide hormones in normal human keratinoctyes". Carcinogenesis 10:13-20, 1989.
Evans, M.G., M.H. El-Fouly and J.E. Trosko: "Detection of inhibition of intercellular
communication by the scrape-loading/dye transfer technique: A concentration/response
study". In Vitro Toxicology 2:101-108, 1989.
Chang, C.C. and J.E. Trosko: "Aphidicolin Mutants". In: Drug Resistance in Mammalian
Cells, Vol. 1, R.S. Gupta, Ed., CRC Press, Boca Raton, FL, pp. 29-43, 1989.
Mori, T., A.A. Wani, S.M. D'Ambrosio, C.C. Chang and J.E. Trosko: "In situ pyrimidine
dimer determination by laser cytometry". Photochem.Photobiol. 49:523-526, 1989.
Dotto, G.P., M.H. El-Fouly, C. Nelson and J.E. Trosko: "Similar and synergistic inhibition
of gap-junctional communication by ras transformation and tumor promoter treatment of
mouse primary keratinocytes. Oncogene 4:637-641, 1989.
Madhukar, B.V., J.E. Trosko and C.C. Chang: "Chemical, oncogene, and growth factor
modulation of gap junctional communication in carcinogenesis". In: Cell Interactions
and Gap Junctions, Vol. 1, N. Sperelakis, W.C. Cole, Eds., CRC Press, Boca Raton, FL,
pp. 143-157, 1989.
Trosko J.E. and C.C. Chang: “Stem cell theory of carcinogenesis” Toxicology Letters
49:283-295, 1989.
El-Fouly, M.H., J.E. Trosko, C.C. Chang and S.T. Warren: "Potential role of the human
Ha-ras oncogene in the inhibition of gap junctional intercellular communication”.
Molecular Carcinogenesis 2:131-135, 1989.
Trosko, J.E.: "Towards understanding carcinogenic hazards: A crisis in paradigms”. J.
of Amer. College of Toxicology 8:1121-1132, 1989.
Jankun, J., F. Matsumura, H. Kaneko, J.E. Trosko, A. Pellicer and A.H. Greenberg:
"Plasmid-aided insertion of MMTV-LTR and ras DNAs to NIH 3T3 fibroblast cells makes
them responsive to 2,3,7,8-TCDD causing overexpression of p21-ras and downregulation of EGF receptor”. Molecular Toxicology 2:177-186, 1989.
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Trosko, J.E. and C.C. Chang: "Chemical tumor promoters, oncogenes and growth
factors: Modulator of gap junctional intercellular communication". In: Pharmacological
Effects of Lipids: The Role of Lipid in Carcinogenesis and Therapy. J. Kabara, Ed.,
American Oil Chemical Society Press. pp. 107-115, 1990.
Trosko, J.E., C.C. Chang and B.V. Madhukar: "Cell to cell communication: Relationship
of stem cells to the carcinogenic process”. In: Mouse Liver Carcinogenesis: Mechanisms
and Species Companions. D.E. Stevenson, J.A. Popp, J.M. Ward, R.M. McClain, T.J.
Slaga, H.C. Pitot, eds., Wiley-Liss Publ., NY, pp. 259-276, 1990.
Trosko, J.E., C.C. Chang, B.V. Madhukar and S.Y. Oh: "Chemical, oncogene and growth
regulator modulation of extracellular, intracellular and intercellular communication”. In:
Cell Intercommunication. W.C. DeMello, CRC Press, Boca Raton, FL, pp. 111-131, 1990.
Li, I.C., C.C. Chang and J.E. Trosko: "Thymidylate synthetase gene as a quantitative
mutation marker in Chinese hamster cells”. Mutation Res. 243:233-239, 1990.
Trosko, J.E., C.C. Chang, B.V. Madhukar and S.Y. Oh: "Modulators of gap junction
function: The scientific basis of epigenetic toxicology”. In Vitro Toxicology 3:9-26,
1990.
Ye, Y.X., D. Bomick, K. Hirst, G. Zhang, C.C. Chang, J.E. Trosko and T. Akera: "The
modulataion of gap junctional communication by gossypol in various mammalian cell
lines in vitro”. Fund. Appl. Toxicol. 14:817-832, 1990.
Lin, Z.X., C.C. Chang and J.E. Trosko: "Gap junctional intercellular communication in rat
glioma cells - characterization to detect inhibitors of metabolic cooperation”. Science in
China 33:435-444, 1990.
Hasler, C., M.A. Frick, M.R. Bennink and J.E. Trosko: "TPA-induced inhibition of gap
junctional intercellular communication is not mediated through free radicals”. Toxicol.
Appl. Pharmacol. 103:389-398, 1990.
Trosko, J.E.: "Critique of intercellular communication in bronchial epithelial cells: A
review of evidence for a possible role in lung carcinogenesis”. Toxicol. Pathology
18:341-343, 1990.
Trosko, J.E., C.C. Chang and B.V. Madhukar: "Modulation of intercellular communication
during radiation and chemical carcinogenesis”. Radiat. Res. 123:241-251, 1990.
Blair, A., O. Axelson, C. Franklin, O.E. Paynter, N. Pearce, D. Steveson, J.E. Trosko, H.
Vainio, G. Williams, J. Woods and S.H. Zahm: "Carcinogenic effects of pesticides”. In:
Advances in Modern Environmeental Toxicology: The Effect of Pesticides on Human
Health. Vol. XVIII, M.A. Mehlman, Ed., Princeton Sci. Publ., Princeton, NJ, pp. 201-261,
1990.
Trosko, J.E., C.C. Chang, B.V. Madhukar and J.E. Klaunig: "Chemical, oncogene and
growth factor inhibition of gap junctional intercellular communication: An integrative
hypothesis of carcinogenesis”. Pathobiology 58:265-278, 1990.
De Feijter, A.W., J.S. Ray, C.M. Weghorst, J.E. Klaunig, J.I. Goodman, C.C. Chang, R.J.
Ruch and J.E. Trosko: "Infection of rat liver epithelial cells with V-Ha-ras: Correlation
between oncogene expression, gap junctional communication, and tumorigenicity”.
Molec. Carcinogenesis 3:54-67, 1990.
Trosko, J.E., C.C. Chang and B.V. Madhukar: "In vitro analysis of modulators of
intercellular communication: Implications for biologically based risk assessment models
for chemical exposure”. Toxicol. In Vitro 4:635-643, 1990.
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Trosko, J.E. and C.C. Chang: "Gap junctional intercellular communication in neoplasia:
Implications for the cause and treatment of cancer". In: Familial Adenomatous
Polyposis. L. Herrera, Ed., Alan R. Liss, Inc., NY, pp. 279-288, 1990.
Mori, T., T. Matsunaga, C.C. Chang, J.E. Trosko and O. Nikaido: "In situ (6-4)
photoproduct determination by laser cytometry and autoradiography”. Mutat. Res.
236:99-105, 1990.
Loch-Caruso, R., I.A. Corcos and J.E. Trosko: "Inhibition of metabolic coupling by
metals. J. Toxicol. Environ. Health 32:33-48, 1991.
Kuslikis, B.I., J.E. Trosko and W.E. Braselton: "Mutagenicity and effect on gap-junctional
intercellular communication of 4,4'-methylenebis(2-chloroaniline) and its oxidized
metabolites”. Mutagenesis 6:19-24, 1991.
Trosko, J.E.: "Possible role of intercellular communication in the modulation of the
biological response to radiation”. Yokohama Med. Bull. 42:151-165, 1991.
Hasler, C.M., M.R. Bennink and J.E. Trosko: "Inhibition of gap junction-mediated
intercellular communication by alpha-linolenate”. Am. J. Physiol. 261:C161-C168, 1991.
Hasler, C.M., J.E. Trosko and M.R. Bennink: "Incorporation of n-3 fatty acids into WBF344 cell phospholipids inhibits gap junctional intercellular communication”. Lipids
26:788-792, 1991.
Kalimi, G.H, L.L. Hampton, J.E. Trosko, S.S. Thorgeirsson and A.C. Huggett:
"Homologous and heterologous gap-junctional intercellular communication in v-raf-, vmyc-, and v-raf/v-myc-transduced rat liver epithelial cell lines”. Mol. Carcinog. 5:301310, 1992.
Trosko, J.E.: "Does radiation cause cancer?" RERF Update 3-5, Spring 1992.
Trosko, J.E., C.C. Chang, E. Dupont, B.V. Madhukar and G. Kalimi: "Chemical modulation
of gap junctional intercellular communication in vitro: An in vitro biomarker of epigenetic
toxicology”. In: In Vitro Methods in Toxicology, G. Jolles, A. Cordier, Eds., Academic
Press, London, pp. 465-478, 1992.
Trosko, J.E.: "Does radiation 'cause' cancer?" J. Hiroshima Med. Assoc. 45:1330-1333,
1992.
Ruch, R.J., B.V. Madhukar, J.E. Trosko and J.E. Klaunig: "Reversal of ras-induced
inhibition of gap junctional intercellular communication, transformation, and
tumorigenesis by lovastatin”. Mol. Carcinog. 7:50-59, 1993.
Trosko, J.E., B.V. Madhukar and C.C. Chang: "Endogenous and exogenous modulation
of gap junctional intercellular communication: Toxicological and pharmacological
implications”. Life Sciences 53:1-19, 1993.
Oh, S.Y., E. Dupont, B.V. Madhukar, J-P. Briand, C.C. Chang, E. Beyer and J.E. Trosko:
"Characterization of gap junctional communication-deficient mutants of a rat liver
epithelial cell line”. Eur. J. Cell Biol. 60:250-255, 1993.
Dupont, E, B.V. Madhukar and J.E. Trosko: "Suppression of gap-junction gene
expression by growth factors and TPA in human epidermal keratinocytes in vitro". In:
Progress in Cell Research, J.E. Hall, G.A. Zampighi and R.M. Davis, Eds., Elsevier Science
Publishers, pp. 321-327, 1993.
Chaudhuri, R., K. Sigler, E. Dupont, J.E. Trosko, A.M. Malkinson and R.J. Ruch: "Gap
junctional intercellular communicatin in mouse lung epithelial cell lines: Effects of cell
transformation and tumor promoters”. Cancer Letters 71:11-18, 1993.
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Trosko, J.E., C.C. Chang, B.V. Madhukar and E. Dupont: "Oncogenes, tumor suppressor
genes, and intercellular communication in the 'oncogeny as partially blocked ontogeny'
hypothesis”. In: New Frontiers in Cancer Causation, O.H. Iversen, Ed., Taylor and
Francis Publ., Washington, DC, pp. 181-197, 1993.
de Feijter, A.W., J.E. Trosko and M.H. Wade: "Assessment of gap junctional intercellular
communication in living cells using fluorescence techniques”. In: Fluorescent and
Luminescent Probes for Biological Activity, W.T. Mason, Ed., Academic Press Inc., San
Diego, CA, pp. 378-388, 1993.
Trosko, J.E.: "Modulation of gap junction function: The scientific basis of epigenetic
toxicology”. In: Environmental and Industrial Toxicology: Research and Applications, M.
Ruchirawat, Ed., in press.
Jou, Y.S., D.F. Matesic, E. Dupont, S.-C. Lu, H.L. Rupp, B.V. Madhukar, S.Y. Oh, J.E.
Trosko and C.C. Chang: "Restoration of gap junctional intercellular communication in a
communication-deficient rat liver cell mutant by transfection with connexin 43 cDNA".
Molecular Carcinogenesis 8:234-244, 1993.
Ruch, R.J., W.J. Bonney, K. Sigler, L. Guan, D.F. Matesic, L.D. Schafer, E. Dupont and
J.E. Trosko: "Loss of gap junctions from DDT-treated rat liver epithelial cells”.
Carcinogenesis 15:301-306, 1994.
Jou, Y.S., B. Layhe, C.C. Chang, L. Lockwood, C.W. Welsch, J.E. Klaunig and J.E. Trosko:
"Inhibition of gap junctional intercellular and malignant transformation of rat liver
epithelial cells by infection with the neu oncogene". Molecular Carcinogenesis 16:311318, 1995.
Trosko, J.E., C.C. Chang and B.V. Madhukar: "The role of modulated gap junctional
intercellular communication in epigenetic toxicology". Risk Analysis 14:303-312, 1994.
Trosko, J.E. and J.E. Goodman: "Intercellular Communication may facilitate apoptosis:
Implications for tumor promotion". Molecular Carcinogenesis 11:8-12, 1994.
Trosko, J.E.: "Radiation induced carcinogenesis: Paradigm considerations". In:
Biological Effects of Low Level Exposures: Dose-Response Relationships. E. Calabrese,
Ed., Lewis Publishers, Chelsea, MI, pp. 205-241, 1994.
Esinduy, C.B., C.C. Chang, J.E. Trosko and R.J. Ruch: "In vitro growth inhibition of
neoplastically transformed cells by non-transformed cells: Requirement for gap
junctional intercellular communication". Carcinogenesis 16:915-922, 1995.
Ruch, R.J., W.J. Bonney, K. Sigler, L. Guan, D.F. Matesic, L.D. Schafer, E. Dupont and
J.E. Trosko: "Loss of gap junctions from DDT-treated rat liver epithelial cells".
Carcinogenesis 15:301-306, 1994.
Trosko, J.E.: "Dose-response studies of genotoxic rodent carcinogens: Thresholds,
hockey sticks, hormesis or straight lines?" BELLE Newsletter 3:10-14, 1995.
Matesic, D.F., H.L. Rupp, W.J. Bonney, R.J. Ruch and J.E. Trosko: "Changes in gap
junction permeability phosphorylation, and number mediated by phorbol ester and nonphorbol ester tumor promoters in rat liver epithelial cells". Molec. Carcinogenesis
10:226-236, 1994.
Upham, B.L., S.J. Masten, L.R. Lockwood and J.E. Trosko: "Nongenotoxic effects of
polycyclic aromatic hydrocarbons and their ozonation by-products on the intercellular
communication of rat liver cells". Fund. Appl. Toxicol. 23:470-475, 1994.
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Upham, B.L., J.J. Yao, J.E. Trosko and S.J. Masten: "Determination of the efficacy of
ozone treatment systems using a gap junction intercellular communication bioassay".
Environ. Sci. Technol. 29:2923-2929, 1995.
Kang, K.-S., M.R. Wilson, T. Hayashi, C.C. Chang and J.E. Trosko: "Inhibition of gap
junctional intercellular communication in normal human breast epithelial cells after
treatment with pesticides, PCBs and PBBs, alone or in mixtures". Environ. Health
Perspect. 104:192-200, 1996.
Trosko, J.E.: "Biomarkers for low-level exposure causing epigenetic responses in stem
cells". Stem Cells 13:231-239, 1995.
Trosko, J.E., C.C. Chang, B.V. Madhukar and E. Dupont: "Intercellular communication:
A paradigm for the interpretation of the initiation/promotion/ progression model of
carcinogenesis". In: Chemical Induction of Cancer: Modulation and Combination
Effects. J.C. Arcos, M.F. Argus, Y.T. Woo, Eds., Birkhauser Publisher: Boston, pp. 205225, 1996.
de Feijter, A.W., D.F. Matesic, R.J. Ruch, X. Guan, C.C. Chang and J.E. Trosko:
"Localization and function of the connexin43 gap junction protein in normal and various
oncogene-expressing rat liver cells". Molec. Carcinogenesis 16:203-212, 1996.
Upham, B.L., L.M. Weis, A.M. Rummel, S.J. Masten and J.E. Trosko: "The effects of
anthracene and methylated anthracenes on gap junctional intercellular communication in
rat liver epithelial cells". Fund. Appl. Toxicol. 34:260-264, 1996.
Hayashi, T., C.M. Hasler, S.Y. Oh, B.V. Madhukar, C.C. Chang and J.E. Trosko: "A
human kidney epithelial cell culture as an in vitro model to study chemical modulation of
intercellular communication". In Vitro Toxicol. 9:3-17, 1996.
Hashimoto, M.W., O. Nikaido, N. Kobayashi, C.C. Chang, J.E. Trosko and T. Mori: "A
comparison of the propensity for gene amplification between near-tetraploid and neardiploid V79 clones resistant to 150 mM methotrexate". Carcinogenesis 17:389-394,
1996.
Nomata, K., K.-S. Kang, T. Hayashi, D.F. Matesic, L. Lockwood, C.C. Chang and J.E.
Trosko: "Inhibition of gap junctional intercellular communication in heptachlor and
heptachlor epoxide-treated normal human breast epithelial cells". Cell Biol. Toxicol.
12:69-78, 1996.
Xing, S., P.A. Smanik, M.J. Oglesbee, J.E. Trosko, E.L. Mazzaferri and S.M. Jhiang:
"Characterization of rat oncogenic activation in MEN2 inherited cancer syndromes".
Endocrinology 137:1512-1519, 1996.
Hofer, A., J.C. Saez, J.E. Trosko, C.C. Chang, D.C. Spray and R. Dermietzel: "CerbB2/neu transfection induces gap junctional communication-incompetence in glial
cells". J. Neurosciences 16:4311-4321, 1996.
Trosko, J.E.: "Role of low-level ionizing radiation in the multi-step carcinogenic process".
Health Physics 70:812-822, 1996.
Madhukar, B.V., H.L. de Feijter-Rupp and J.E. Trosko: Pulse treatment with the tumor
promoter TPA delays the onset of desensitization response and prolongs the inhibitory
effect on gap junctional intercellular communication of a rat liver epithelial cell line WBF344". Cancer Letters 106:117-123, 1996.
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249.
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253.
Matesic, D.F., T. Hayashi, J.E. Trosko and J.A. Germak: "Upregulation of gap junctional
intercellular communication in immortalized gonadotropin-releasing hormone neurons by
stimulation of the cyclic AMP Pathway". Neuroendocrinology 64:286-297, 1996.
Lyng, F.M., H.L. de Feijter-Rupp, T. Hayashi, K. O’Malley, D.M. Murphy, D.C. Cottell, J.E.
Trosko, C.B. Seymour and C. Mothersill: “Effect of a tobacco-related nitrosamine on
intercellular communication in human urothelial cells: A possible factor in smokingrelated bladder carcinogenesis”. Oncology Res. 8:371-378, 1996.
Upham, B.L., K.-S. Kang, H.-Y. Cho and J.E. Trosko: “Hydrogen peroxide inhibits gap
junctional intercellular communication in glutathione sufficient but not glutathione
deficient cells”. Carcinogenesis 18:37-42, 1997.
Trosko, J.E.: “Challenge to the simple paradigm that ‘carcinogens’ are ‘mutagens’ and to
the in vitro and in vivo assays used to test the paradigm”. Mutation Res. 373:245-249,
1997.
Upham, B.L., B. Boddy, X. Xing, J.E. Trosko and S.J. Masten: “Non-genotoxic effects of
selected pesticides and their disinfection by-products on gap junction intercellular
communication”. Ozone Science and Engineering, 19:351-369, 1997.
Hayashi, T., D.F. Matesic, K. Nomata, K.-S. Kang, C.C. Chang and J.E. Trosko:
“Stimulation of cell proliferation and inhibition of gap junctional intercellular
communication by linoleic acid”. Cancer Letters 112:103-111, 1997.
Trosko, J.E. and T. Inoue: “Oxidative stress, signal transduction and intercellular
communication”. In: Radiation Injury and the Chernobyl Catastrophe. N. Dainiak, W.J.
Schull, L. Karkanitsa and O.A. Aleinikova. Stem Cells 15:59-67, 1997.
Wygoda, M., M.W. Wilson, M.A. Davis, J.E. Trosko, A. Rehmetulla and T.S. Lawrence:
“Protection of Herpes simplex virus thymidine-kinase transduced cells from ganciclovirmediated cytotoxicity by bystander cells: The Good Samaritan effect”. Cancer Res.
57:1699-1703, 1997.
Kang, K.-S. M. Ikue, A. Cruz, Y.J. Jeon, J.E. Trosko and C.C. Chang: “Expression of
estrogen receptors in a normal human breast epithelial cell type with luminal and stem
cell characteristics and its neoplastic transformed cell lines”. Carcinogenesis 18:251257, 1997.
Madhukar, B.V. and J.E. Trosko: “Insights into the causes of cancer: Their implications
to the prevention and treatment”. Indian J. Pediatrics 64:131-142, 1997.
Holland, M.S., R.F. Silva, J.E. Trosko and M.R. Wilson: “Differences in gap junctional
intercellular communication between cells infected with either attenuated or oncogenic
Marek’s disease virus”. In: Current Research for Marek’s Disease. R.F. Silva, H.H.
Cheng, P.M. Coussens, L.F. Lee and L.F. Velicer, Eds., Rose Printing Co., Tallahasee, FL,
pp. 290-295, 1997.
Trosko, J.E.: "Radiation, signal transduction and modulation of intercellular
communication". In: Effects of Ionizing Radiation: Atomic Bomb Survivors and Their
Children (1945-1995). L.E. Peterson and S. Abrahamson, Eds., Joseph Henry Press:
Washington, DC, pp. 177-192, 1998.
Wilson, M.R., I. Umeh, K.-S. Kang and J.E. Trosko: “A role for mitogen activated protein
kinase (MAPK) during ras-induced down regulation of gap junctional intercellular
communication”. In: Gap Junctions. R. Werner, Ed. IOS Press, Amsterdam, pp. 239243, 1998.
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264.
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Kang, K.-S., C.C. Chang and J.E. Trosko: “Modulation of gap junctional intercellular
communication during human breast stem cell differentiation and immortalization”. In:
Gap Junctions. R. Werner, Ed. IOS Press, Amsterdam, pp. 347-351, 1998.
Wilson, M.R. and J.E. Trosko: “The balance between birth and death: Apoptosis,
mitosis, and gap junctions”. In: Gap Junctions. R. Werner, Ed. IOS Press, Amsterdam,
pp. 367-371, 1998.
Trosko, J.E.: “Hierarchical and cybernetic nature of biologic systems and their relevance
to homeostatic adaptation to low-level exposures to oxidative stress-inducing agents”.
Environ. Health Perspect. 106:331-339, 1998.
Trosko, J.E. and R.J. Ruch: “Cell-cell communication in carcinogenesis”. Frontiers in
Bioscience 3:208-236, 1998.
Weis, L.M., A.M. Rummel, S.J. Masten, J.E. Trosko and B.L. Upham: “Bay or bay-like
regions of polycyclic aromatic hydrocarbons were potent inhibitors of gap junctional
intercellular communication”. Environ. Health Perspect. 106:17-22, 1998.
Hayashi, T., K. Nomata, C.C. Chang, R.J. Ruch and J.E. Trosko: “Cooperative effects of
v-myc and c-Has-ras oncogenes on gap junction intercellular communication and
tumorigenicity in rat liver epithelial cells”. Cancer Letters, 128:145-154, 1998.
Lawrence, T.S., A. Rehemtulla, E.Y. Ng, M.R. Wilson, J.E. Trosko and P.L. Stetson:
“Preferential cytotoxicity of cells transduced with cytosine deaminase compared to
bystander cells after treatment with 5-flucytosine”. Cancer Res. 58:2588-2593, 1998.
Upham, B.L., L.M. Weis and J.E. Trosko: “Modulated gap junctional intercellular
communication as a biomarker of PAH’s epigenetic toxicity in structure/function
relationship”. Environ. Health Perspect. 106:975-981, 1998.
de Feijter-Rupp, H. L., T. Hayashi, G.H. Kalimi, P. Edwards, J.L. Redpath, C.C. Chang,
E.J. Stanbridge and J.E. Trosko: “Restored gap junctional communication in nontumorigenic Hela-normal human fibroblast hybrids”. Carcinogenesis 19:747-754, 1998.
Rae, R.S., P.P. Mehta, C.C. Chang, J.E. Trosko and R.J. Ruch: “Neoplastic phenotype of
gap-junctional intercellular communication-deficient WB rat liver epithelial cells and its
reversal by forced expression of connexin 32”. Molecular Carcinogenesis 22:120-127,
1998.
Kang, K.S., W. Sun, K. Nomata, I. Morita, A. Cruz, C.J. Liu, J.E. Trosko and C.C. Chang:
“Involvement of tyrosine phosphorylation of p185c-erbB2/neu in tumorigenicity induced by
x-rays and the neu oncogene in human breast epithelial cells”. Molecular Carcinogenesis
21:225-233, 1998.
Trosko, J.E.: “Modulation of gap junctional communication during carcinogenesis by
tumor promoters, growth factors and oncogenes: An integrative theory of
carcinogenesis”. ACTA Urologica Italica (Suppl.) Vol. XII – 1:65-68, 1998.
Carruba, G., M.M. Webber, D. Bello, N.D. DeoCampo, M. Miele, A. Cataliotti, V. Bellavia,
J.E. Trosko and L. Castagnetta: “Regolazione delle communicazioni cellula-cellula in
cellule epiteliali di prostata umana non neoplastica e tumorale”. ACTA Urologica Italica
(Suppl.) Vol. XII – 1:65-68, 1998.
Sai, K., B.L. Upham, K.-S. Kang, R. Hasegawa, T. Inoue and J.E. Trosko: “Inhibitory
effect of pentachlorophenol on gap junctional intercellular communication in rat liver
epithelial cells in vitro”. Cancer Letters 130:9-17, 1998.
23
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273.
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275.
276.
277.
278.
279.
280.
281.
Upham, B.L., N.D. DeoCampo, B. Wurl and J.E. Trosko: “Inhibition of gap junctional
intercellular communication by perfluorinated fatty acids is dependent on the chain
length of the fluorinated tail”. Int. J. Cancer 78:491-495, 1998.
Trosko, J.E.: “Mechanism of tumor promotion: Chemical carcinogen-induced oxidative
stress, signal transduction and modulated cell-cell communication”. J. Toxicological
Sciences 23:257, 1998.
Trosko, J.E., C.C. Chang, B.L. Upham and M.R. Wilson: “Epigenetic toxicology as
toxicant-induced changes in intracellular signalling leading to altered gap junctional
intercellular communication”. Toxicology Letters 102-103:71-78, 1998.
Ghoshal, S., W.J. Weber, Jr., A.M. Rummel, J.E. Trosko and B.L. Upham: “Epigenetic
toxicity of a mixture of polycyclic aromatic hydrocarbons on gap junctional intercellular
communication before and after biodegradation”. Environ. Sci. Technol. 33:1044-1050,
1999.
Rummel, A.M., J.E. Trosko, M.R. Wilson and B.L. Upham: “Polycyclic aromatic
hydrocarbons with bay-like regions inhibited gap junctional intercellular communication
and stimulated MAPK activity”. Toxicological Sciences 49:232-240, 1999.
Carruba, G., M.M. Webber, D. Bello-Deocampo, R. Amodio, M. Notarbartolo, N.D.
Deocampo, J.E. Trosko and L.A.M. Castagnetta: “Laser scanning analysis of cell-cell
communication in cultured human prostate tumor cells”. Anal. Quan. Cytology Histology
21: 54-58, 1999.
Kamendulis, L.M., J. Jiang, H. Zhang, H. de Feijter-Rupp, J.E. Trosko and J.E. Klaunig:
“The effects of acrylonitrile on gap junctional intercellular communication in rat
astrocytes”. Cell Biol. Toxicol. 15:173-183, 1999.
Ogawa, T., T. Hayashi, S. Kyoizumi, T. Ito, J.E. Trosko and N. Yorioka: “Up-regulation
of gap junctional intercellular communication by hexamethylene bisacetamide in cultured
human peritoneal mesothelial cells”. Laboratory Investigation 79:1511-1520, 1999.
Sun, W., K.S. Kang, I. Morita, J.E. Trosko and C.C. Chang: “High susceptibility of a
human breast epithelial cell type with stem cell characteristics to telomerase activation
and immortalization”. Cancer Res. 59: 6118-6123, 1999.
Ruch, R.J. and J.E. Trosko: “The role of oval cells and gap junctional intercellular
communication in hepatocarcinogenesis”. Anticancer Research 19: 4831-4838, 1999.
Trosko, J.E.: “Comments on ‘What is a Tumor Promotor?’” Environ. Health Perspect.
107: A597-A599, 1999.
Dowling-Warriner, C.V. and J.E. Trosko: “Induction of gap junctional intercellular
communication, connexin43 expression, and subsequent differentiation in human fetal
neuronal cells by stimulation of the cyclic AMP pathway”. Neurosciences 95:859-868,
2000.
Wilson, M.R., T.W. Close and J.E. Trosko: “Cell population dynamics (apoptosis, mitosis,
and cell-cell communication) during disruption of homeostasis”. Experimental Cell Res.
254:257-268, 2000.
Trosko, J.E., C.C. Chang, M.R. Wilson, B.L. Upham, T. Hayashi and M. Wade: “Gap
junction and the regulation of cellular functions of stem cells during development and
differentiation”. Methods 20: 245-264, 2000.
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287.
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289.
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291.
292.
293.
294.
295.
296.
Kang, K.-S., B.-C. Kang, B.-J. Lee, J.-H. Che, G.-X. Li, J.E. Trosko and Y.-S. Lee:
“Preventive effect of epicatechin and ginsenoside Rb2 on the inhibition of gap junctional
intercellular communication by TPA and H2O2”. Cancer Letters 152: 97-106, 2000.
Chang, C.C., C.J. Liu, W. Sun, M. Saitoh and J.E. Trosko: “Role of ionizing radiation in
neoplastic transformation of human breast epithelial cells”. Radiation Res. 2: 576-579,
2000.
Suzuki, J., H.-K. Na, B.L. Upham, C.C. Chang and J.E. Trosko: “Lambda-carregeenaninduced inhibition of gap junction intercellular communication in rat liver epithelial cells”.
Nutrition and Cancer 36: 122-128, 2000.
Trosko, J.E. “The discovery of a ‘Biological Rosetta Stone’: Its implications for radiation
and chemical carcinogenesis”. Radiation Res. 2: 571-575, 2000.
Trosko, J.E.: “Cloning of human stem cells: Some broad scientific and philosophical
issues”. J. Lab. Clin. Med. 135: 432-436, 2000.
Trosko, J.E.: “Human health consequences of environmentally-modulated gene
expression: Potential Roles of ELF-EMF induced epigenetic versus mutagenic
mechanisms of disease”. Bioelectromagnetics 21: 402-406, 2000.
DeoCampo, N.D., M.R. Wilson and J.E. Trosko: “Cooperation of bcl-2 and myc in the
neoplastic transformation of normal rat liver epithelial cells is related to the down
regulation of gap junction-mediated intercellular communication”. Carcinogenesis 21:
1501-1506, 2000.
Na, H.-K., M.R. Wilson, K.-S. Kang, C.C. Chang, D. Grunberger and J.E. Trosko:
“Restoration of gap junctional intercellular communication by caffeic acid phenethyl ester
(CAPE) in a ras-transformed rat liver epithelial cell line”. Cancer Letters 157: 31-38,
2000.
Sai, K., J. Kanno, R. Hasegawa, J.E. Trosko and T. Inoue: “Prevention of the downregulation of gap junctional intercellular communication by green tea in the liver of mice
fed pentachlorophenol”. Carcinogenesis 21: 1671-1676, 2000.
Chen, G., B.L. Upham, W. Sun, C.C. Chang, E. Rothwell, K.M. Chen, H. Yamasaki and
J.E. Trosko: “Effect of electromagnetic field exposure on chemically-induced
differentiation of friend erythroleukemia cells”. Environ. Health Perspect. 108:967-972,
2000.
Trosko, J.E. and C.C. Chang: “Modulation of cell-cell communication in the cause and
chemoprevention/chemotherapy of cancer”. BioFactors 12:259-263, 2000.
Ruch, R. J., Trosko, J.E.,: “Gap-junction communication in chemical carcinogenesis”.
Letter to the Editor, Drug Metabolism Reviews 33:117-121, 2001.
Chang, C.C., W. Sun, A. Cruz, M. Saitoh, M.-H. Tai and J.E. Trosko: “A human breast
epithelial cell type with stem cell characteristics as target cells for carcinogenesis”.
Radiation Res. 155: 201-207, 2001.
Chang, C.C., Liu, C.J., Sun, W., Saitoh, M., and Trosko, J.E.: “Roles of ionizing radiation
in neoplastic transformation of human breast epithelial cells”. In Radiation Research, Vol.
2 (Moriaty, M., Mothersill, C., Seymour, C., Edington, M., Ward, J.F., and Fry, R., J.M.,
Eds., pp. 576-579., 2000.
Trosko, J.E. and C.C. Chang: “Role of stem cells and gap junctional communication in
human carcinogenesis”. Radiation Res. 155: 175-180, 2001.
25
297.
Hayashi, T., Trosko, J.E., and Hamada, K.: “Inhibition of gap junctional intercellular
communication in rat liver epithelial cells with transforming RNA”. FEBS Letters, 491:
200-206, 2001.
298. Masten, S.J., M. Tian, B.L. Upham, and J.E. Trosko: “Effect of selected pesticides and
their ozonation by-products on gap junctional intercellular communication using rat liver
epithelial cell lines”. Chemosphere 44: 457-465, 2001.
299. Trosko, J.E.: “Gap junctional intercellular communication: A ‘Biological Rosetta Stone’
concept for understanding ‘Epigenetic’ toxicology”. J. Toxicol. Pub. Health 17: 1-9,
2001..
300. Trosko, J.E., Chang, C.C., and Upham, B.L.: “Modulation of gap junctional
communication by ‘epigenetic’ toxicants: A shared mechanism in teratogenesis,
carcinogenesis, atherogenesis, immunomodulation, reproductive- and neuro-toxicities”.
In: Biomarkers of Environmentally Associated Disease. S.H. Wilson and W.A. Suk, eds.,
Lewis Publishers, Boca Raton, Fl., pp. 445-454, 2002.
301. Trosko, J.E.: “Is the concept of ‘tumor promotion’ a useful paradigm?” Molecular
Carcinogenesis, 30: 131-137, 2001.
302. Trosko, J.E., C.C Chang, and B. L. Upham: “Mechanism of up-regulated gap junctional
intercellular communication during chemoprevention and chemotherapy of cancer”.
Mutation Research 480-481: 219-229, 2001.
303. Phipps, M., Jouishomme, H., Lacelle, S., Phipps, J., and Trosko, J.E.: “Proliferation
kinetics in cell spheroids: Evidence of a direct involvement of gap junction intercellular
communication in tissue homeostasis”. Submitted to Science.
304. Wilson, M.R., W.B. Coleman, W. Sun, R. Ruch, H.-K. Na, K.-S. Kang, N. Deocampo, C.C.
Chang, and J.E. Trosko: “Differentiation potential and neoplastic transformation of V-src
and polyomavirus T-antigen transfected rat liver epithelial stem-like cells”. Submitted to
Cell Growth & Differentiation.
305. Carruba, G., M.M. Webber, S.T.A. Quader, M. Amoroso, F. Saladino, J.E. Trosko, and
L.A.M. Castagnetta: “Regulation of cell-to-cell communication in non-tumorigenic and
malignant human prostate epithelial cells”. The Prostate 50: 73-82, 2002.
306. Luster-Teasley, S.L., Yao, J.J., Herner, H.H., Trosko, J.E., and Masten, S.A.: “Chrysene
ozonation: Evaluation of mixtures and identification of toxic constituents”. Environmental
Science and Technology 36: 869-876, 2002.
307. Trosko, J.E.: “From bacteria to humans: Lessons learned from a reductionist’s view of
ultraviolet light induced DNA lesions”. Environ.Molec. Mutagen. 38: 118-121, 2001.
308. Herner, H. A., Trosko, J.E., and Masten, S.: The epigenetic toxicity of pyrene and related
ozonation byproducts containing an aldehyde functional group”. Environmental Science
and Technology 35: 3576-3583, 2001.
309. Tai, M.H., Madhukar, B.V., Olson, L.K., Van Camp, L., Tsao, M.S., and Trosko, J.E.:
Characterization of gap junctional intercellular communication in immortalized human
pancreatic ductal epithelial cells with stem cell characteristics”. Pancreas 26: e18-e26,
2003.
310. Ruch, R. J., Trosko, J.E. and Madhukar, B.V.: Inhibition of connexin 43 gap junctional
intercellular communication by TPA requires ERK activation. J. Cellular Biochem. 83:
163-169, 2001.
26
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315.
316.
317.
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319.
320.
321.
322.
323.
324.
Sai, K., Kang, K.S., Hirose, A., Hasegawa, R., Trosko, J.E., and Inoue, T.: “ Inhibition of
apoptosis by pentachlorophenol in V-myc-transfected rat liver epithelial cells: Relation to
Down-regulation of gap junctional intercellular communication”., Cancer Letters 173:
163-174, 2001
Ogawa, T., Hayashi, T., Yorioka, N., Kyoizumi, S., and Trosko, J.E.: “Hexamethylene
bisacetamide protects peritonel mesothelial cells from glucose”. Kidney International, 60:
996-1008, 2001.
Horvath, A., Upham, B.L., Ganev, V., and Trosko, J.E., “Determination of the epigenetic
effects of ochratoxin in a human kidney and a rat liver epithelial cell line. Toxicon 40:
273-282, 2002.
Saunders, M.M., You, J., Trosko, J.E., Yamasaki, H., Li, Z. Donahue, H.J., Jacobs, C.R.:
Gap junctions and fluid flow response in MC3T3-E1 cells”. Amer. J. Physiol.-Cell Physiol.
281: 1917-1925, 2001.
Zhou, H., Suzuki, M., Randers-Pehrson, G., Vannals, D., Chen, G., Trosko, J.E., Waldren,
A., and Hei, T. K.: “ Radiation risks to low fluences of alpha particles may be greater
than we think” Proc. Natl. Acad. Sci. USA 98: 14410-14415, 2001.
Trosko, J.E. and Chang, C.C.: “Epigenetic- toxicology induced modulated gap junctional
intercellular communication”. In : Comphrehensive Toxicology , Vol. xiv., Vanden
Heuval, J.P., Perdew, G.H., Mattes., W.B., and Greenlee, W.F. ( eds.), Elsevier Science,
Amsterdamn, pp. 409-419, 2002.
Trosko, J.E. “Van Rensselaer Potter: A measure of the man, scientist, scholar”.
Itinerarium 10: 85-89, 2002.
Hilscherova, K., A. Blankenship, M. Nie, K. Coady, B.L. Upham, J.E. Trosko, J.P. Giesy
(2003). Oxidative stress in liver and brain of the hatchling chicken (Gallus domesticus)
following in ovo injection with TCDD. Comparative Biochem. Physiol. C, 136:29-45.
Hilscherova, K., A. Blankenship, K. Kannan, M. Nie, L.L. Williams, K.Coady, B.L. Upham,
J.E. Trosko, S.Bursian, J.P. Giesy (2003). Oxidative stress in laboratory-incubated
double-crested cormorant eggs collected from the Great Lakes. Arch. Environ.
Contamination Toxicol. 45:533-546.
Hu, W., Jones, P.D., Upham, B.L., Trosko, J.E., Lau, C., and Giesy, J.P. “ Inhibition of
gap junctional intercellular communication by perfluorinated compounds in rat liver
and dolphin kidney epithelial cell lines in vitro and Sprague-Dawley rats in vivo”.
Toxicol. Sci. 68: 429-436, 2002
Trosko, J.E. and Ruch, R. J. “Gap junctions as targets for cancer chemoprevention and
chemotherapy”, Current Drug Targets, 3: 465-482, 2002.
Trosko,
J.E.
“Up-regulation
of
cell-cell
communication
in
the
st
chemoprevention/chemotherapy of cancer cells”. In: Chemicals in the 21 Century:
Chemicals for Sustainable Development. Chulabhorn Research Institute.
Trinity
Publishing Co., Ltd., Bangkok, Thailand, pp. 180-186, 2002.
Trosko, J.E. and Chang, C.C., “Isolation and characterization of normal adult human
epithelial pluripotent stem cells”. Oncology Res. 13: 353-357, 2003.
Trosko, J.E. “Human stem cells as targets for the aging and diseases of aging
processes”. Medical Hypo.60: 439-447, 2003.
27
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327.
328.
329.
330.
331.
332.
333.
334.
335.
336.
337.
338.
Upham, B.L., Koski, T.R., Rummel, A.M., Wilson, M.R., Horvath, A., and Trosko, J.E.,
“Differential roles of 2, 6 and 8 carbon ceramides on the modulation of gap junctional
communication and apoptosis during carcinogenesis”. Cancer Letters 191: 27-34, 2003.
Trosko, J.E. “Bioethics: A philosophical basis for moral decisions”. Global Bioethics 15:
47-51, 2002.
Satoh, A.Y., Trosko, J.E., and Masten, S.J., “The epigenetic toxicity of hydroxylated
biphenyls and hydroxylated polychlorinated biphenyls on normal rat liver epithelial cells”.
Environ. Sci. Technol. 37:2722- 2733, 2003.
Machala, M., Blaha, L., Vondracek, J., Trosko, J.E., Scott, J., and Upham, B.L., “
Inhibition of gap junctional intercellular communication by noncoplanar polychlorinated
biphenyls: Inhibitory potencies and screening for potential mode(s) of action”. Toxicol.
Sci. 76: 102-111, 2003.
Trosko, J.E.: Reduced gap junctional intercellular communication and altered biological
effects in mouse osteoblast and rat liver oval cell lines transfected with dominantnegative connexin43. Molec. Carcinogen.37: 192-201, 2003.
Holland, M.S., Tai, M.H., Trosko, J.E., Griffin, L.D.,
Stasko, J.A., Cheville, N.C.,
Holland, R.E., “Isolation and differentiation of bovine mammary gland progenitor cell
populations. Am. J. Vet. Res.64: 396-403, 2003.
Trosko, J.E.: Scientific concepts of human nature and their implications to bioethics in
a scientific and technologically—altered world. J. Internatl. Soc. Bioethics. 9; 68-83,
2003.
Trosko, J.E. “Bioethics: A philosophical basis for moral decisions”. Global Bioethics 15:
47-51, 2002.
Satoh, A.Y., Trosko, J.E., and Masten, S.J., “The epigenetic toxicity of hydroxylated
biphenyls and hydroxylated polychlorinated biphenyls on normal rat liver epithelial cells”.
Environ. Sci. Technol. 37:2727- 2733, 2003.
Ogawa, T,, Hayashi, T., Kyoizumi, S., Kusunoki, Y., Nakachi, K., MacPhee, D.G.,
Trosko, J.E., Kataoka,K., and Yorioka,N : Anisomycin Downregulates Gap Junctional
Intercellular Communication via p38 MAP Kinase Pathway. J. Cell Science ePress 117:
2087-2096,2004.
Trosko, J.E. and Chang, C.C., Hallmarks of radiation carcinogenesis: Ignored concepts.
Radiation and humankind: Internatl. Congress Series #1258. Shibata, Y., Yamashita,
S., Watanabe, M., and Tomonaga, M., eds. Elsevier, Amsterdam. Pp. 31-36, 2003.
Nakamura, Y., Trosko, J.E., Chang, C.C., and Upham. B.L., Psyllium extracts decrease
neoplastic phenotypes induced by the Ha-Ras oncogene transfected into a rat liver
oval cell line. Cancer Letters 203: 13-24, 2004.
Luster-Teasley, S.L., Ganey, P.E., DiOrio, M., Ward, J.S., Maleczka,R.E., Trosko, J.E.,
and Masten, S.J., “The effects of Byproducts from ozonation of pyrene: Biphenyl2,2’,6,6’-tetracarbaldehyde and biphenyl-2,2’,6,6’-tetracarboxylic acid on gap junction
intercellular communication and neutrophil function, Environ. Toxicolog. Chem. 24:
733-740, 2005.
Moggs, J.G., Goodman, J.I., Trosko, J.E., and Roberts, R.A. “Epigenetics and cancer:
implications for drug discovery and safety assessment. Toxicol. Applied
Pharmacol.,196: 422-430, 2004.
28
339.
340.
341.
342.
343.
344.
345.
346.
347.
348.
349.
350.
351.
352.
353.
Linning, K.D., Tai, M.H., Madhukar, B.V., Chang, C.C., Reed, D.N., Ferber, S., Trosko,
J.E. and Olson, L.K. “Redox-mediated enrichment of self-renewing adult human
pancreatic cells which possesses endocrine differentiation potential”. Pancreas 29:
e64-e76, 2004.
J.E. Trosko, “The role of stem cells and gap junctional intercellular communication in
carcinogenesis”.J. Biochem.Molec. Biol., 36: 43-48, 2003.
Upham, B.L., Rummel, A.M., Carbone, J.M., Trosko, J.E., Ouyang, Y., Crawford, R.B.,
and Kaminski, N.E., “Cannnabinoids inhibit gap junctional intercellular communication
and activate ERK in a rat liver epithelial cell line.” Interntl. J. Cancer 104: 12-18, 2003.
Trosko, J.E., “Van R. Potter: A measure of the man, scientist, scholar”. Studia
Bobolanum 4: 79-82, 2003.
Trosko, J.E., “Scientific concepts of human nature and their implications to Bioethics in
a scientific and technologically-altered world”. Studia Bobolanum 4: 111-126, 2003.
Loch-Caruso, R., B. L. Upham, C. Harris, ,J. E. Trosko, Divergent roles for glutathione
in Lindane-induced biphasic inhibition of rat myometrial gap junctions., Tox. Sci, 85:
694-702, 2005.
Loch-Caruso, R., B.L. Upham, C, Harris, and J.E. Trosko, Biphasic Lindane-induced
oxidation of glutathione and inhibition of gap junctional intercellular communication in
myometrial cells. Toxicol. Sci. 86: 417-426, 2005.
J-S Park, D-Y Noh, S-H Kim, S-H Kim, G Kong, C C Chang, Y-S Lee, J E Trosko and K-S
Kang. Gene expression analysis in SV40-immortalized human breast luminal epithelial
cells with stem cell characteristics using a cDNA microarray, International J. of
Oncology, 24:1545-1558,2004.
Davila, J.C., Cezar, G.G., Thiele, M, Strom, S., Miki, T., and Trosko, J.E. “Use and
application of stem cells in toxicology”. Toxicological Sci., 79: 214-223, 2004.
T Ogawa, T Hayashi, S Kyoizumi, Y Kusunoki, K Nakachi, DG MacPhee, JE Trosko, K
Kataoka, N Yorioka: “Anisomycin downregulates gap-junctional intercellular
communication via the p38 MAP-kinase pathway”. J. Cell Sci. 117: 2087-2096. 2004.
M. Saitoh, J.E. Trosko, and C.C. Chang, “ Maspin, a tumor suppressor gene, is
expressed in human basal breast epithelial cells but not in breast epithelial stem cells
and breast cancer cells”. Submitted.
Yasushi Nakamura, Noriko Yoshikawa, Ikumi Hiroki, Kenji Sato, Kozo Ohtsuki, ChiaCheng Chang, Brad L. Upham, and James E. Trosko. “-Sitosterol, From Psyllium Seed
Husk (Plantago ovata Forsk), Restores Gap Junctional Intercellular Communication in
Ha-ras Transfected Rat Liver Cells. Nutrition and Cancer, 5: 218-225, 2005.
Trosko, J.E., Chang, C.C., Upham, B.L., Tai, M.H.,” Ignored hallmarks of
carcinogenesis: Stem cells and cell-cell communication. Ann .N.Y. Acad. Sci., 1028:
192-201, 2004.
Nakamura, Y., Chang, C.C., Mori, T., Sato, K., Ohtsuki, K., Upham, B.L., and Trosko,
J.E. “Augmentation of differentiation and gap junction fubction by kaempferol in
partially-differentiation colon cancer cells”. Carcinogenesis, 26: 665-671, 2005.
Tai, M.H., Chang, C.C., kiupel, M., Webster, J.D., Olson, L.K. and Trosko, J.E., “Oct-4
expression in adult human stem cells: evidence in support of the stem cell theory of
carcinogenesis. Carcinogenesis 26: 495-502, 2005.
29
354.
355.
356.
357.
358.
359.
360.
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361.
362.
363.
364.
365.
Trosko, J.E. “The role of stem cells and cell-cell communication in radiation
carcinogenesis: ignored concepts”. Brit. J. Radiol., 78: 1-7, 2005.
Trosko, J.E. and Upham, B.L. “The emperor wears no clothes in the field of carcinogen
risk assessment: Ignored concepts in cancer risk assessment”. Mutagenesis 20: 81-92,
2005.
Trosko, J.E. and Ruch, R.J. “Gap junctional Intercellular Communication in Epigenetic
Toxicology” In: Encyclopedia of Toxicology, 2nd Ed., P. Wexler, ed., Elsevier Press,
Oxford, pp. 402- 407, 2005.
Upham, B.L. and Trosko, J.E. “A paradigm shift in the understanding of oxidative
stress and its Implications to exposures of low level ionizing radiation”. Acta Medica
Nagasakiensia, 50: 63-68, 2005.
Trosko, J.E., Chang, C.C., Upham, B.L., and Tai, M.H.,” Low dose ionizing radiation
induction of differential intracellular signaling possibly affecting intercellular
communication. Radiation Environmental Biophysics 44: 3-9, 2005.
Trosko, J.E., “Dietary modulation of multi-stage, multi-mechanisms of
human carcinogenesis: Effects of initiated stem cells and cell-cell
communication “, Nutrition and Cancer, 54(1), 102–110, 2006.
Trosko, J.E., and Tai, M.H., “Adult stem cell theory of the multi-stage, multimechanism theory of carcinogenesis: Role of inflammation on the promotion of
initiated cells”. In: Infections and Inflammation: Impacts on Oncogenesis, T.
Dittmar, K.S. Zaenker, and Schmidt, eds., S. Karger AG, Publisher, Contributions
to Microbiology , Vol. 13 Infection and Inflammation: Impacts on Oncogenesis”,
pg. 45-65, 2006
Trosko, J.E., Chang, C.C., Upham, B.L., and Tai, M.H., “The role of human adult stem
cells and cell-cell communication in cancer chemoprevention and chemotherapy
strategies”. Mutat. Res., 591: 187-197, 2005.
Ogawa, T., Hayashi, T., Tokunou, M., Nakachi, K., Trosko, J.E., Chang, C.C., and
Yorioka, N., “Suberoylanilide hydroxamic acid enhances gap junctional intercellular
communication via acetylation of histone containing connexin43 gene locus”. Cancer
Res. 65: 9771-9778, 2005.
Trosko, J.E., “The role of stem cells and gap junctions as targets for cancer
chemoprevention and chemotherapy”. Biomedicine & Pharmacotherapy 59: 326-331,
2005.
Nishikawa, A., Sai, K., Okazaki, K., Son, H.Y., Kanki, K., Nakajima, M., Kinae, N.,
Nohmi, T., Trosko, J.E., Inmoue, T., and Hirose, M., “ MX, a by-product of water
chlorination, lacks in vivo genotoxicity in gpt delta mice but inhibits gap junctional
intercellular communication in rat WB cells”. Environ. Mol. Mutagen., 47: 48-55, 2006.
Hirabayashi, Y., Yoon, B-I, Tsuboi,I., Huo, Y., Kodama, Y., Kanno, J., Ott, T., Trosko,
J.E., and Inoue, T., “ Role of connexin32 in steady state hematopoiesis , regeneratingstate and in prevention of chemically-induced leukemogenesis”. Exp Biol Med.
232(5):700-12, 2007
30
366.
367.
368.
369.
370.
371.
372.
373.
Tai, M.-H., Reed, D.N., Chang, C.C., Olson, L.K., Trosko, J.E., “Characterization of
Human pancreatic cells that possess endocrine differentiation potential”. Surgery,
Submitted.
de Flora, S., Scafi, S., Izzotti, A., D’Agostini, F., Chang, C.C., Bagnasco, M., De Flora,
A., and Trosko, J.E., “ Induction by 7, 12-dimethylbenz(a) anthracene of molecular
and biochemical alterations in stem cell-derived human mammary epithelial cells, and
protection by N-acetylcysteine”. Internatl. J. Oncology, 29:521-529, 2006
Trosko, J.E. From adult stem cells to cancer stem cells: Oct-4 gene, Cell-Cell
Communication, and Hormones during tumor promotion. Ann. N.Y. Acad. Sci., 1089:
36-58, 2006.
Satoh, A.Y., Trosko, J.E., and Masten, S.J., “Methylene blue dye test for rapid
qualitative detection of hydroxyl radicals formed in a Fenton’s reaction aqueous
solution”. Environ.Sci. Sci. Technol., 41:2881-2887, 2007
Tai, M.H., Upham, B.L., Olson, L.K., Tsao, M.S., Reed, D.N., and Trosko, J.E.,
“Cigarette smoke condensate inhibited intercellular communication and differentiation
in human pancreatic ductal epithelial cells”.Int. J. Cancer 120: 1855-1862, 2007.
Martin, F.L. , Esteller, M., Herceg, Z., Mathers, J.C., Minucci, S., Lim, F.L., Trosko, J.E.,
“ Epigenomics and disease”; 10th Ann. Winter Meeting of UK Molecular Epidemiology
Group; The Royal Statistical Society, London. Dec. 8th, 2006: Mutagenesis,
doi:10.1093/mutage/gem037, 1:-3, 2007
Hirabayashi, Y., Yoon, B., Tsuboi, I., Huo, Y., Kodama, Y., Kanno, J., Ott, T., Trosko,
J.E., Inoue, T. “Membrane channel connexin 32 maintains Lin-/c-kit hematopoietic
progenitor cell compartment: Analysis of the cell cycle. J. Membr. Biol., 217:105-113,
2007.
Trosko, J.E. “Aging as the ‘Systems’ breakdown of communication between the quality
and quantirty of stem cells. In : The Manefesto for a Long Life [ Il Manifesto Della
Lunga Vita]. Marandola, P. & Marotta, F., eds., Sperling & Kupfer Editori S.p.A, Milan,
Italy, pp. 58-62, 2007.
374.
Upham,B.L., Guzvic, M., Scott, J., Carbone, J.M., Blaha, L., Coe, C., Li, L.L., Rummel,
A.L. and J.E. Trosko, “ Inhibition of gap junctional intercellular communication and
activation of mitogen-activation protein kinase by tumor-promoting organic peroxides
and protection by resveratrol”. Nutrition Cancer 57: 38-47, 2007
375.
Trosko J.E. “Concepts needed to understand potential health effects of chronic lowlevel radiation exposures: Role of adult stem cells and modulated cell-cell
communication. Internatl. Congress Series 1299: 101-113, 2007.
376.
Trosko , J.E., “ Gap junction intercellular communication as a ‘Biological Rosetta Stone’
in understanding , in a Systems manner, stem cell behavior, mechanisms of epigenetic
toxicology, chemopreventyion and chemotherapy”. J. Membr. Biol.218: 93-100, 2007
31
377.
Vondracek, J, Svihalkova-Sindlerova,L., Pencikova, K., Marvanova, S., Krcmar, P.,
Ciganek, M., Neca, J., Trosko, J.E., Upham, B., Kozubik, A., and Machala, M., “
Concentrations of methylaqted naphthalenes, Anthracenes, and phenanthrenes
occurring in Czech river sediments and their effects on toxic events associated with
carcinogenesis in rat liver cell lines”. Environ. Toxicol.Chemistry 26: 2308-2316, 2007.
378. Trosko, J.E., “Stem cells and cell-cell communication in the understanding of the role
Of diet and nutrients in human diseases. J. Food Hygiene & Safety 22: 1-14, 2007.
379. Webster, J.D., Yuzbasiyan-Gurkan, V., Trosko, J.E., Chang, C.C., and Kiupel, M,
“Expression of the embryonic transcription factor Oct4 in canine neoplasms: A
potential marker for stem cell subpopulations in neoplasis. Vet. Pathol., 44: 893-900,
2007.
382.
Upham, B.; Blaha, L.; Babica, P.; Park.; Sovadinova, I.; Pudrith, C.; Rummel, A.; Weis,
L.; Sai, K.; Tithof, P.; Guzvic, Miodrag; V., J.; Machala, M.; Trosko, J., “Inhibition of
intercellular signaling, a tumor promotion event, by a cigarette abundant PAH, depends
on phosphatidylcholine-specific phospholipase C. Cancer Sci., 99: 696-705, 2008
383. Umannová L., Neča J., Andrysík Z., Vondráček J., Upham B.L., Trosko J.E., Hofmanová
J., Kozubík A., Machala M. “Non-dioxin-like polychlorinated biphenyls induce a release
of arachidonic acid in liver epithelial cells: A partial role of cytosolic phospholipase A2
and extracellular signal-regulated kinases 1/2 signaling” . Toxicology, 247:55-60, 2008.
384. Upham, B.L. and Trosko, J.E., “Carcinogenic tumor promotion, induced oxidative stress
signaling, modulated gap junction function and altered gene expression”. Antioxidants
& Redox Signaling 11: 297-308, 2009..
385. Nakamura, Y, Nakayama, Y., Ando, H., Tanaka, A., Matsuo, T., Okamoto, S., Upham,
B.L., Chang, C.C., Trosko, J.E., Park, E. Y., Sato, K. “3-Methylthio-propionic acid ethyl
ester, isolated from Katsura-uri (Japanes pickling melon, Cucumis melo var. conomon),
enhanced differentiation in human colon can cells”, J. Agriculture and Food Chem.. 56,
2977–2984, 2008
386. Trosko, J.E. “Commentary: Re-Programming or Selecting adult stem cells. Stem Cell
Reviews, 4: 81-88, 2008.
387. Trosko, J.E., “Human adult stem cells as targets for cancer stem cells: Evolution; Oct-4
gene and cell-cell communication”.In: Stem Cells and Cancer, Dittmar, T., & Zaenkar,
K., eds., Nova Publishers, XXXC., in press.
388. Trosko, J.E. “Role of diet and nutrition on the alteration of the quality and quantity of
stem cells in human aging and the diseases of aging”. Curr Pharm Des. 14: 2707-2718,
2008.
32
389. Weber,T. J., Quesenberry, R.D., Burghardt, R.C.,. Trosko,J. E., Monks, T.J. and
Lau, S.S. “Inhibition of TXA2 Receptor Function by Dominant Negative Connexin
43”, submitted.
390. Upham B.L., Park, J-K, Babica, P., Sovadinova, I., Rummel, A.M., Trosko, J. E.,
Hirose, A., Hasegawa, R., Kanno, J., and Sai, K., Structure-Activity-Dependent
Regulation of Cell Communication by Perfluorinated Fatty Acids Using in vivo
and in vitro Model Systems. Environ. Health Perspect., 117: 1-8, 2009.
391. Trosko, J.E. & Suzuki, K. Adult stem cells, the Barker Hypothesis , epigenetic
events and low level radiation effects. In: Radiatiation Health Risk Sciences.
M.Nakashima, N. Takamura, K. Tsukasaki, Y. Nagayama, S. Yamashita, eds.,
Springer Publisher, Tokyo, pp.216-226, 2009.
392. Trosko, J.E. Upham, B.L., Can Chemicals be considered as “Mutagenic Carcinogens” in
the application of the mode of action (MOA) in Cancer Risk Assessment”, Environ.
Mutagenesis, submitted.
393. Trosko, J.E., Green Tea and potential human health effects. Green Tea and Heath,
Nova Science Publishers, N.Y., in press.
394. Trosko, J.E., Potentials and limitations of human stem cells as a tool in toxicology.
Toxicology of the Blood and bone Marrow. 2nd Ed., J. Descoters, ed., Taylor & Francis,
New York, in press.
395. Trosko, J.E., Cancer stem cells and cancer non-stem cells: From adult stem cells or
from re-programming of differentiated somatic cells. Vet. 46: 176-193, 2009.
396. Trosko, J.E. "Cancer ? A Stem Cell-based disease?”, Stem Cell Biology in Health and Disease.
K. S. Zaenkar and T. Dittmar, Spring Publishers, in preparation.
397. Holland, M.S., Coleman, W.B., Trosko, J.E., Neoplastic restoratoration by exogenous tumor
suppressor gene in microcell hybrid is independent from gap junction intercellular
communication, in preparation.
398. Saitoh, M., Trosko, J.E. and Chang, C.C., Maspin, a tumor suppressor gene, is expressed in
human basal breast epithelial cells but not in breast epithelial stem cells and breast cancer cells”.
In preparation.
399. Nakamura ,Y, Kominami, A., Tsujimoto, Y., Nakayama, Y., Kitahashi, T.,
Kido, Y., Kobayashi, Y., Kuwahata, M., Chang, C.C., Upham, B.L., Trosko, J.E.,
Park, E.Y., Sato, K..N-Terminal deleted proteins of Actin and
Vimentin detected in tumor bearing rat liver induced by intraportal-vein injection of
Ha-ras transfected rat liver cells. Int. J. Cancer 124: 2512-2519, 2009.
400. Trosko, J.E., “Human adult stem cells as the target cells for the initiation of
33
carcinogenesis and for the generation of “cancer stem cells”. Internatl. J. Stem
Cells 1: 8-26, 2008.
401. Heddle, J., Trosko, J.E., Chu, E.H.Y. Obituary: Sheldon Wolff. Mutation Research/
Fundamental and Molecular Mechanisms of Mutagenesis, 662: 1-2, 2009.
402. Cocciadiferro,L., Miceli,V., Kang,K.-S., Polito, L.M., Trosko, J.E., Carruba, G.
Profiling cancer stem cells in androgen-responsive and refractory human prostate
tumor cell lines. Ann.N.Y. Acad Sci. 1155: 257-262, 2009.
403. Trosko, J.E. Chang, C.C. Factors to consider in the use of stem cells for
pharmaceutic drug development and for chemical safety assessment. Toxicologist,
in. press.
404. .Trosko, J.E. A tribute to Prof.D.Sc. Ivan Segota: Bioethics as “ His Candle” in the
world of ethical darkness and human suffering”. In: From New Medical Ethics to
Integrative Bioethics. A. Covic, N. Gosic, L. Tomasevic, eds., Pergamena,
Zagreb, Croatia, ppg. 83-86, 2009.
RESEARCH
Notes/Reports
1.
2.
3.
Slatis, H., G. Schutema and J.E. Trosko: "Trachea-broken, an unusual mutant in
Drosophila melanogaster". Semi-annual report, Argonne National Laboratory. ANL-6264,
p. 151, 1959.
Trosko, J.E. and M. Myzewski: "Inhibition of egg-laying in inseminated females".
Drosophila Information Service 37:146, 1963.
Trosko, J.E. and A.F. Yanders: "Cold storage effect on irradiated Drosophila sperm".
Drosophila Information Service 38:36, 1963.
34
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
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20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
Trosko, J.E.: "Studies of enzyme action on isolated chromosomes". ORNL Information
Meetings, 1963.
Trosko, J.E. and S. Wolff: "Studies on the isolation of fixed metaphase chromosomes".
ORNL Semi-Annual Report 3601, p. 39, 1964.
Trosko, J.E., E. Chu and W.L. Carrier: "In vivo induction of thymidine dimers in
mammalian DNA". ORNL Semi-Annual Report 3768, p. 41, 1965.
Trosko, J.E. and J.G. Brewen: "Isolation and studies on mammalian metaphase
chromosomes". ORNL 3768, p. 41, 1965.
Trosko, J.E., E. Chu, L.T. Covington and M.R. Kasschau: "Studies on the types and roles
of UV-induced lesions in mammalian cells". ORNL - Annual Information Meetings, 1965.
Chu, E. and J.E. Trosko: "Effects of ultraviolet radiation on DNA synthesis in
synchronized mammalian cells in vitro". ORNL 3853, p. 189, 1965.
Trosko, J.E.: "Insect tissue culture". ORNL 3853, p. 53, 1965.
Zimmerman, B.K., J.E. Trosko and P. Howard: "DNA polymerase activity in synchronized
mammalian cell cultures". ORNL 3853, p. 193, 1965.
Trosko, J.E., E. Chu, M.R. Kasschau and L. Covington: "UV-induced pyrmidine dimers
during different phases of the cell cycle of mammalian cells". ORNL 3922, p. 40, 1966.
Zimmerman, B.K., J.E. Trosko, P. Howard and M. Kasschau: "DNA polymerase activity in
puromycin treated synchronized mammalian cells". ORNL 3922, p. 158, 1966.
Muhammed. A. and J.E. Trosko: "A search for photoreactivating enzymes in Drosophila
melanogaster extracts". Drosophila Information Service 42, 1966.
Trosko, J.E.: Annual Report - MSU/AEC Plant Research Laboratory, March, 1969.
Trosko, J.E.: "Correlation between radiation and chemical induced molecular damages
in human cells". Annual Technical Progress Report, 1968.
Trosko, J.E.: "Correlation between radiation and chemical-induced molecular damages
and their biological expression in mammalian cells". AEC - Special Report, Fundamental
Nuclear Energy Research, February, 1969.
Trosko, J.E.: "Studies on DNA metabolism in human cells treated with LSD". NIH
Terminal Grant Report, 1974.
Trosko, J.E.: "Terminal Report," NCI Research Career Development Award, 1971-77.
Trosko, J.E.: "Terminal Report," NCI (CA13048-05).
Trosko, J.E.: "Terminal Report," NCI (CA21104).
Trosko, J.E.: "EPA Progress Report," EPA (R8085870).
National Academy of Science, "Asbestiform Fibers: Non-Occupational Health Risks,
National Academy Press, Washington, DC, 1984.
USAFOSR-Terminal report, March, 1989.
Trosko, J.E., "Terminal Report," NCI (CA21104), April, 1991.
Trosko, J.E., "Terminal Report," USAFOSR, May, 1994.
Trosko, J.E., "Terminal Report," NIEHS-Program Project grant, 1994.
Trosko, J.E., "Terminal Report," Mich. Great Lakes Protection Fund grant, 1994.
Trosko, J.E., "Terminal Report," Acrylonitrile Group grant, 1994.
Trosko, J.E., "Annual Report," NCI grant, 1993-1994.
Trosko, J.E., "Annual Report," NCI grant, 1994-1995.
Trosko, J.E., "Annual Report," NCI grant, 1995-1996.
Trosko, J.E., "Annual Report," USAFOSR, 1996.
35
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
44.
45.
46.
47.
Trosko, J.E., "Annual Report," EPRI, 1997.
Trosko, J.E., "Annual Report," NCI grant, 1996-1997.
Trosko, J.E., "Terminal Report," USAFOSR, 1997-1998.
Trosko, J.E., "Terminal Report," EPRI, 1998.
Trosko, J.E., "Annual Report," NCI grant, 1997-1998.
Trosko, J.E., "Competitive Renewal," NCI, 1999.
Trosko, J.E., "Annual Report," EPRI, 1999.
Trosko, J.E. Annual Report, NIEHS, 2000.
Trosko, J.E. Annual Report, NIEHS, 2001
Trosko, J.E. Annual Report, NIEHS, 2002
Trosko, J.E. Annual Report, NIEHS, 2003
Trosko, J.E., Annual Report, NIEHS, 2004
Trosko, J.E., Annual Report, NIEHS, 2005
Trosko, J.E. , Annual Report, NIEHS, 2006
ABSTRACTS
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
Trosko, JE, E Chu and EL Carrier: “In vivoi induction of thymine dimers in mammalian
DNA". American Soc. for Zoologists 4:384, 1964.
Trosko, JE and S Wolff. "Strandedness of mitotic chromosomes of Vicia faba as revealed
by enzyme digestion studies". Am. Soc. Cell Biol. 23:98A, 1964.
Trosko, J.E., M. Kasschau, L. Covington and E.H.Y. Chu: "UV-induction of thymine
dimers in mammalian DNA during different phases of the cell cycle of mammalian cells".
Rad. Res. 27:535, 1966.
Chu, E.H.Y. and J.E. Trosko: "inhibition of DNA synthesis by ultraviolet irradiation in
mammalian cells in vitro". Third International Congress of Radiation Research, Cortina,
Italy, 1966.
Regan, J.D. and J.E. Trosko: "The fate of UV-induced thymine containing dimers in
human cells grown in vitro". Rad. Res. 31:548-549, 1967.
Heddle, J.A. and J.E. Trosko: "Strandedness of chromosomes as indicated by
radiation-induced chromosome aberrations". Rad. Res. 31:576, 1967.
Trosko, J.E. and V. Mansour: "Response of tobacco and Haplopappus cells to
UV-irradiation after posttreatment with photoreactivating light". Fifth International
Congress on Photobiology, Hanover, NH, August 26-31, 1968.
Trosko, J.E. and V. Mansour: "Evidence for photoreactivation of ultraviolet radiation
damage to tobacco cells grown in vitro". Rad. Res. 35:514-515, 1968.
Trosko, J.E. and V. Mansour: "Effects of ultraviolet irradiation on the sedimentation
profiles of BUdR-substituted DNA of Chinese hamster cells". Genetics Society Meetings,
Boston, MA, Nov. 10-13, 1968, in Genetics 60:231, 1968.
Trosko, J.E., V. Mansour, I. Weber and B.K. Zimmerman: "Caffeine stimulated
enhancement of DNA synthesis in UV-irradiated mammalian cells". Biophysics Society
Meetings, Biophysical J. 9:21A, 1969.
Cleaver, J.E. and J.E. Trosko: "The defective stage of DNA repair in a human disease,
Xeroderma pigmentosum". Rad. Res 29:471, 1969.
36
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25.
26.
27.
Trosko, J.E. and V. Mansour: "Possible molecular mechanism for caffeine sensitization a
of ultraviolet light-induced damage in mammalian cells". Madison, WI Aug. 18-20, 1969,
Genetics.
Trosko, J.E. and M. Isoun: "Studies on the photosensitizing effect of trisoralen on
human cells in vitro". Rad.Res.
Trosko, J.E. and M. Isoun: "Synergistic effects of sunlight and the drugs, trisoralen and
caffeine, on human cells in vitro". First Annual Environmental Mutagenesis Society
Meeting, March, 1970.
Diaz, N., P. Markakis and J.E. Trosko: "In vitro inhibition of the growth of human cells
by irradiated sugars". International Radiation Congress, Evian France, June 30 - July,
1970.
Trosko, J.E.: "Mutagenicity of platinum compounds". International Symposium on the
Bacterial, Viral and Anti-Tumor Activities of Platinum Compounds. East Lansing, MI,
Sept. 23-25, 1970.
Trosko, J.E., and E.H.Y. Chu: "Effects of caffeine on the UV-induction of mutations in
Chinese hamster cells". 19th Annual Radiation Research Society Meeting, May 9-13,
1971, Boston, MA.
Trosko, J.E. and K. Wilder: "Repair mechanisms in Drosophila melanogaster". Annual
Meeting of the Genetics Society of America, Aug. 27- 30, 1972, Minneapolis, MN.
Trosko, J.E. and E.H.Y. Chu: "Caffeine-inhibition of post-replication repair of UV and
N-acetoxy-2-acetylaminofluorene-damaged DNA in Chinese hamster cells".
XIII
International Congress of Genetics, Berkley, CA, Aug. 20-24, 1973.
Yager, J., J. Trosko and G.T. Bowden: "DNA synthesis and repair in primary cultures of
rat liver parenchymal cells". Proc. 65th Annual Meeting of the American Assoc. of
Cancer Research, Vol. 15, p. 47, Houston, TX, Mar. 1974.
Trosko, J.E., C.C. Chang, L. Yotti and E.H.Y. Chu: "Mutagenicity of cancer-promoting
agents in cultured Chinese hamster cells". International Symposium: Protein and Other
Adducts to DNA: Their significance to Aging Carcinogenesis and Radiation Biology.
Williamsburg, VA, May 2-6, 1975.
Weichsel, M.E. and J.E. Trosko: "In vivo effect of thyroxine and cyclic AMP on cerebellar
DNA synthesis". Society for Pediatrics Research, 1975.
Yager, J., J.E. Trosko, G.T. Bowden and F. Butcher: "The effects of several croton oil
constituents on DNA repair and cyclic nucleotide levels in cultured mammalian cells".
American Assoc. for Cancer Research, 1975.
Chang, C.C., J.E. Trosko, L. Yotti and E.H.Y. Chu: "Mutagenicity of cancer- promoting
agents in cultured Chinese hamster cells". 6th Annual Environmental Mutagen Society.
May 9-12, 1975, Miami Beach, FL.
Chu, E.H.Y., R.D. Schmickel, Wade, M.H., C.C. Chang and J.E. Trosko: "Ultraviolet light
sensitivity and defect in DNA repair in fibroblasts derived from two patients with
Cockayne syndrome". American Society of Human Genetics, Baltimore, MD, Oct. 8-11,
1975.
Trosko, J.E., C.C. Chang and T. Glover: "The role of genes in carcinogenesis: An
integrative theory". Genetics Society of America, Aug. 1976.
Trosko, J.E. and C.C. Chang: "Use of in vitro DNA repair and mutation assays to detect
environmental mutagens, carcinogens and tumor promoters".
Workshop on
37
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31.
32.
33.
34.
35.
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38.
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40.
41.
42.
Carcinogenesis and Mutagenesis by Energy-Related Hydro-Carbons at Argonne National
Laboratory, April 18-20, 1977.
Trosko, J.E. and C.C. Chang: "Relation between mutagenesis and carcinogenesis". 5th
Annual Meeting of the American Society of Photobiology, May 12-16, 1977, San Juan,
Puerto Rico.
Chang, C.C. and J.E. Trosko: "Characterization of ouabain-resistant mutations in Chinese
hamster cells". Genetics Society Meeting, Austin, TX, August 14-17, 1977, Genetics,
86:(suppl.) 5-11, 1977.
Chang, C.C. and J.E. Trosko: "Chemical modification of UV-induced ouabain- resistant
mutations in Chinese hamster cells in culture". Workshop on Chemical Modification of
Mutagenesis, Williamsburg, VA, Oct. 24-26, 1977.
Trosko, J.E. and C.C. Chang: "Chemical modification of radiation-induced mutagenesis
and its role in carcinogenesis". ICN-UCLA Symposia, "DNA Repair Mechanisms",
Keystone, CO, Feb. 1978.
Trosko, J.E. and C.C. Chang: "Genes, Pollutants and Human Diseases". Joint meeting
of Biophysical Society - American Physical Society, Washington, DC March 27-29, 1978.
Yotti, L.P., J.E. Trosko and C.C. Chang: "Chemical modification of x-ray induced
mutations in Chinese hamster cells". Environmental Mutagen Society, San Francisco,
CA, June 1978.
Schultz, R., C.C. Chang and J.E. Trosko: "Isolation of DNA repair mutants of Chinese
hamster cells". Am. Assoc. Cancer Res. Meetings, Washington, DC, April 5-8, 1978.
Glover, T.W., C.C. Chang and J.E. Trosko:
"Quantitative mutagenesis in human
fibroblasts using diphtheria toxin resistance as a genetic marker". Amer. Assoc. Human
Genetics, Vancouver, Canada, Oct. 1978.
Trosko, J.E., T.W. Glover and C.C. Chang: "UV-induction of diphtheria toxin-resistant
(DTr) mutations in xeroderma pigmentosum fibroblasts". Amer. Assoc. Cancer Res.,
New Orleans, LA.
Chang, C.C., J.E. Trosko and T.W. Glover: "Characterization of diphtheria toxin-resistant
mutations in Chinese hamster V79 cells". Environmental Mutagen Society. New
Orleans, LA, March 1978.
Trosko, J.E. and C.C. Chang: "Potential role of mutagenic and epigenetic mechanisms of
aplastic anemia and leukemia". Conference on Aplastic Anemia, San Francisco, June 17,
1979.
Yotti, L.P. and J.E. Trosko: "Inhibition of metabolic cooperation in mammalian tissue
culture cells by TPA". 30th Annual Tissue Culture Meeting, Seattle, WA, June 10, 1979.
Warren, S.T., J.R. Moskal, P.A. Mason, C.C. Sweeley and J.E. Trosko: "The relationship
between morphology and ornithine decarboxylase activity in cultured human and
hamster cells". 30th Annual Tissue Culture Meeting, Seattle, WA, June 10, 1979.
Trosko, J.E. and C.C. Chang: "UV-induction of diphtheria-toxin resistant mutations in
normal and DNA repair-deficient human and Chinese hamster fibroblasts". Conference
on DNA Repair and Mutagenesis in Eukaryotes. NIEHS, Atlanta, June 25-28, 1979.
Trosko, J.E. and C.C. Chang: "In vitro assay for tumor promoters". Conference on
Short-Term Tests for Chemical Carcinogens. Vancouver, B.C., Aug. 24, 1979.
38
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45.
46.
47.
48.
49.
50.
51.
52.
53.
54.
55.
56.
57.
Trosko, J.E. and C.C. Chang: "Inhibition of metabolic cooperation in mammalian tissue
culture cells by tumor promoters". U.K. Environmental Mutagen Society, University of
Sussex, England, Sept. 10, 1979.
Trosko, J.E. and C.C. Chang: "Chemical promoters: Amplifiers of mutated cells". NIEHS
Conference on Environmental Mutagenesis, Bethesda, MD, November 5, 1979.
Trosko, J.E.: "Tumor promoters: Use of an in vitro assay for their detection and
mechanism of action". Environ. Mutagen Soc. Meeting, Nashville, TN, March 17, 1980.
Moskal, J., S.T. Warren, M. Lockney, C. Marvel, J.E. Trosko and C. Sweeley: "Studies on
the functional involvement of membrane glycoconjugates in tumor promotion".
ICN-UCLA Symposia, Keystone, CO, March 2, 1980.
Chang, C.C., P.K. Liu, S.T. Warren, J.A. Boezi, R.A. Schultz and J.E. Trosko: "Isolation
and partial characterization of 1 aphidicolin-resistant Chinese hamster cells". Environ.
Mutagen Society Meeting, Nashville, TN, March 17, 1979.
Marvel, C. and J.E. Trosko: "Enhancement of endogenous phosphorylation in membrane
preparations by phorbol ester tumor promoters". Amer. Soc. Biol. Chem., New Orleans,
LA, June, 1980.
Doolittle, D., S.T. Warren, J.E. Trosko, C.C. Chang and J. Goodman: "An in vitro
mammalian assay system for the detection of toxic and mutagenic chemicals. Amer.
Society of Pharmacology and Environmental Toxicology.
Warren, S.T., R.A. Schultz, C.C. Chang and J.E. Trosko: "Elevated spontaneous
mutation rate in Bloom's syndrome fibroblasts". American Society of Human Genetics,
NY, Sept. 1980.
Trosko, J.E., L.P. Yotti, S. Warren and C.C. Chang:
"Inhibitions of cell- cell
communication by tumor promoters". Symposium on CoCarcinogenesis and Biological
Effects of Tumor Promoters. Klais, Germany, Oct. 13-16, 1980.
Moskal, J., S. Warren, L. Yotti, M. Lockney, C. Marvel and J.E. Trosko: "Studies on the
functional involvement of membrane glycoconjugates in tumor promoters". American
Society of Biology and Chemistry, New Orleans, LA, June, 1980.
Trosko, J.E. and C.C. Chang: "The use of various mammalian cell mutants to study the
mechanisms of mutagenesis, tumor promotion and teratogenesis". Japanese Tissue
Culture Assoc., International Symposium on Mutagenesis and Carcinogenesis, Dec. 4-5,
1980, Tokyo, Japan.
Trosko, J.E. and C.C. Chang: "The role of mutations and epigenetic changes in aging".
AAAS Meeting, Toronto, Canada, Jan. 9, 1981.
Trosko, J.E., S.T. Warren, M.H. Wade and C.C. Chang: "The role of error- prone DNA
replication in mammalian mutagenesis/carcinogenesis initiation".
1981 ICN-UCLA
Symposia on Molecular and Cellular Biology, Keystone, CO, Feb. 22-Mar. 1, 1981.
Trosko, J.E., G. Tsushimoto, C.C. Chang and S.D. Aust: "Inhibition of metabolic
cooperation in Chinese hamster cells by specific congeners of polybrominated biphenyls.
Society of Toxicology, San Diego, CA, Mar. 2-5, 1981.
Wade, M.H., S.T. Warren, C.C. Chang and J.E. Trosko: "Characterization of the UV
response in Bloom syndrome fibroblasts. American Association of Cancer Research,
April, 1981, Washington, DC.
39
58.
59.
60.
61.
62.
63.
64.
65.
66.
67.
68.
69.
70.
71.
72.
Chu, E.H.Y., T. Featherstone, I.C. Li, C.C. Chang and J.E. Trosko: "Mutation studies in
human somatic cells". Third International Conference on Environmental Mutagens.
Tokyo, Japan, Sept. 21-27, 1981.
Jensen, R.K., J.E. Goodman, J.E. Trosko, S.D. Aust, and S.D. Sleight: "Assessment of
the capacity of polybrominated biphenyls to serve as promoters of carcinogenesis".
Society of Toxicology meeting, Boston, MA, Feb. 22-26, 1981.
Jensen, R.K., S.D. Sleight, J.E. Goodman, C.D. Mills, S.D. Aust and J.E. Trosko:
"Assessment of the capacity of 3,3',4,4',5,5'-hexabromobiphenyl to serve as a promoter
of heptacarcinogenesis". Society of Toxicology meeting, Boston, MA, Feb. 22-26, 1982.
Wade, M.H., J.E. Trosko and C.C. Chang: "Enhanced survival and decreased mutation
frequency after photoreactivation of UV damage in rat kangaroo cells". Environmental
Mutagen Society, Boston, MA, Feb. 26-Mar.2, 1981.
Huang, Y.Q., C.C. Chang and J.E. Trosko: "Aphidicolin induces endoreduplication in
Chinese hamster cells". Genetics, 100:5-31, 1982. Genetics Society Meeting, New
Haven, CT, June 13, 1982.
Cousineau, A.J., C.C. Chang, J.E. Trosko, S.T. Warren, G. Lu, S. Kapur and J.V. Higgins:
Familial transmission of cancer susceptibility and hypersensitivity to DNA damaging
agents. American Society of Human Genetics, Detroit, MI, October 1982.
Trosko, J.E., C. Jone, C. Rubinstein, G. Tsushimoto and C.C. Chang: Role of inhibited
intercellular communication in tumor promotion and teratogenesis". 13th International
Cancer Congress. Seattle, WA, Sept. 8-16, 1982.
Trosko, J.E., C. Jone and C.C. Chang: "Effect of promoters on metabolic cooperation:
New Academy of Sciences, Oct. 5-7, 1982.
Aylsworth, C.F., C. Jone, J.E. Trosko and C.W. Welsch: "Influence of unsaturated fatty
acids on metabolic cooperation between Chinese hamster cells in vitro. AACR meeting,
May 25-28, 1983, San Diego, CA.
Jensen, R.K., S.D. Sleight, J.I. Goodman, C.D. Millis, S.D. Aust and J.E. Trosko: "Toxic
and non-toxic doses of 3,4,5,3',4',5'-hexabromobiphenyl as promoters of
hepatocarcinogenesis”.. 22nd Annual Society of Toxicology meeting, Las Vegas, NV,
Mar. 7-11, 1983.
Jone, C., J.E. Trosko, L. Parker, C.C. Chang: "In vitro assay to detect chemical inhibitors
of gap junction-mediated intercellular communication". Tissue Culture Association
meeting, Orlando, FL, June 12-16, 1983.
Aust, S.D., J.E. Trosko and S.D. Sleight: "Toxicity and carcinogenicyt of polybrominated
biphenyls". 13th Conference on Environmental Toxicology, Dayton, OH, Nov. 16-18,
1982.
Chang, C.C., Y.Q. Huang, M.H. Wade, J.E. Trosko: "Hyperthermia modulation of
UV-induced cytotoxicity, mutation and chromosomal aberrations in Chinese hamster V79
cells". Genetics Society of America, June 12-16, 1982, St. Louis, MO.
Trosko, J.E., C. Jone, L. Parker, and C.C. Chang: "In vitro assay to detect chemical
inhibitors of gap junction-mediated intercellular communication: Screen for potential
teratogens, tumor promoters and reproductive toxicants". EPA Symposium, Chicago,
April 8-10, 1983.
Trosko, J.E. and C.C. Chang: "Error-prone DNA repair and replication in relation to
malignant transformation".
1st International Conference on "Carcinogenesis,
40
73.
74.
75.
76.
77.
78.
79.
80.
81.
82.
83.
84.
85.
86.
Immunology and Transplantation: Environmental and Host Factors". Roswell Park
Memorial Institute, Buffalo, NY, April 24-28, 1983.
Trosko, J.E., C. Jone, C.C. Chang and A. Medcalf: "Short-term test for tumor promoters
using inhibited intercellular communication". Symposium on Role of Cocarcinogens and
Promoters in Human and Experimental Carcinogenesis. Budapest, Hungary, May 16-18,
1983.
Trosko, J.E., C. Jone and C.C. Chang:
"A possible mechanistic link between
teratogenesis and carcinogenesis: Inhibited intercellular communication". International
Workshop on Carcinogenesis, Mutagenesis and Teratogenesis. Shanghai, China, May
25-June 1, 1983.
Trosko, J.E. and C.C. Chang: "Mammalian Mutagenesis". XVth International Congress
on Genetics, New Delhi, India, Dec. 12-21, 1983.
Jone, C., C. Rubinstein, J.E. Trosko and C.C. Chang: "Inhibition of intercellular
communication in cultures of Chinese hamster cells by 2,4,5-T and 2,4-D". Symposium
on Dioxins in the Environment. E. Lansing, MI, Dec. 6-7, 1983.
Trosko, J.E. and C.C. Chang: "Mechanisms of Human Cellular Promotion". Symposium
on Carcinogenic Mechnanisms in Cultured Human Tissue and Cells. Ohio Valley-Lake
Erie Assoc. of Cancer Centers, Columbus, OH, April 29, 1984.
Trosko, J.E., C.C. Chang and H.J. Kung: "Potential role of src gene product in the
inhibition of gap-junctional intercellular communication". AACR meeting, Toronto,
Canada, May 9-12, 1984.
Aylsworth, C.F., C. Jone, J.E. Trosko and C.W. Welsch: "Importance of the Cis-double
bond orientation in the inhibition of metabolic cooperation between Chinese hamster
cells in vitro by unsaturated fatty acids". AACR meeting, Toronto, Canada, May 9-12,
1984.
Trosko, J.E. and C.C. Chang: "Role of tumor promotion in the multi-step nature of
carcinogenesis". Symposium on Assessment of Risk from Low Level Exposure to
Radiation and Chemicals", Brookhaven National Laboratories, May 20-23, 1984.
Trosko, J.E. and C.C.Chang: "Detection of non-mutagenic and non-cytotoxic hazardous
chemicals". Tissue Culture Assoc. meeting, Houston, TX, June 3-7, 1984.
Liu, P.K., S. Fredell, C.C. Chang, J.E. Trosko, T. Norwood and L.A. Loeb: "Toward
cloning of the DNA polymerase alpha gene". 3rd Int. Congress of Cell Biology, Sept.
3-4, 1984, Kyoto, Japan.
Kavanagh, T.J., C.C. Chang and J.E. Trosko:
"Characterization of a human
teratocarcinoma cell line for use as a screening assay for inhibitors of gap
junction-mediated cell-cell communication". Soc. Environ. Toxicol. and Chem., Rockville,
MD, Nov. 4-7, 1984.
Bradley, R.H., C.S. Han, C.C. Chang, K. Phelan and J.E. Trosko: "Partial characterization
of gap junction proteins from Chinese hamster V79 and human (HTp3) cell lines. Soc.
Cell. Biol., Kansas City, Nov. 1984.
Trosko, J.E., C.M. Jone, L. Parker and C.C. Chang: "Biological toxins as possible
inhibitors of gap-junctional communication". Soc. Toxicol., San Diego, CA, 1985.
Loch-Caruso, R. and J.E. Trosko: "Potential role of intercellular communication in
morphogenesis of hydra aggregates". Soc. for Pediatric Research, Washington, DC,
1985.
41
87.
Trosko, J.E., C. Jone and C.C. Chang: "Adaptive and non-adaptive consequences of
chemical inhibition of cellular communication by toxic stustances. 15th Conference on
Environmental Toxicology, Dayton, OH, Oct. 30, 1984.
88. Loch-Caruso, R. and J.E. Trosko: "Inhibition of metabolic cooperation by metal
compounds". Michigan Chapter of Society of Toxicology, May 16, 1985.
89. Bombick, D., C.C. Chang, J.E. Trosko and F. Matsumura: "Elevated protein kinase C
activity in oncogene transfected and transformed NIH 3T3 cells". Amer. Assoc. Cancer
Res., Houston, TX, May 22-25, 1985.
90. Trosko, J.E. and C.C. Chang: "In vitro detection of chemicals which inhibit intercellular
communication". Amer. Chem. Soc. Mtg., Akron, OH, June 5, 1985.
91. Trosko, J.E. and C.C. Chang: "Oncogene and chemical inhibition of gap- junctional
intercellular communication: Implications for teratogenesis and carcinogenesis". 4th
Intern. Conf. Environ. Mutagens, Stockholdm Sweden, June 24-28, 1985.
92. Rezabek, M.S., J.E. Trosko, C. Jone and S.D. Sleight: "Hepatic tumor promoters
phenobarbital and polybrominated biphenyls inhibit metabolic cooperation between rat
liver epithelial cells". Soc. Tox. Mtg., New Orleans, LA, March 3-7, 1986.
93. Draznin, M.B., M.H. El-Fouly, L.M. Erickson and J.E. Trosko. Drugs and factors which
promote growth of aorta smooth muscle cells in vitro block cell-cell communication:
Application of a rapid in vitro assay. Amer. Fed. Clinical Res., Washington, D.C., May,
l985.
94. El-Fouly, M.H. and J.E. Trosko: "Scrape loading and dye transfer: a rapid and simple
technique for the detection of intercellular communication”. Tissue Culture Assoc. Mtg.,
Chicago, June 11-15, l986.
95. Draznin, M.B., M.H. El-Fouly, L.M. Erickson and J.E. Trosko: "Insulin blocks cell-cell
communication in cultured bovine aorta smooth muscle cells”. Amer. Diabetes Assoc.
Mtg., Washington, D.C., 1986.
96. Loch-Caruso, R., I.A. Corcos and J.E. Trosko:
Acetic acid derivatives of
2-methoxyethanol and 2-ethoxyethanol fail to inhibit metabolic cooperation. Tissue
Culture Assoc. Mtg., Chicago, June ll-l5, l986.
97. Chang, C.C., J.E. Trosko, R. Givson-D'Ambrosio and S.M. D'Ambrosio: "Contact
insensitivity of a subpopulation of normal human fetal kidney epithelial cells and of
human carcinoma cell lines. Amer. Assoc. Cancer Res. Mtg., Los Angeles, May, 1986.
98. Aylsworth, C.F., J.E. Trosko and C.W. Welsch: "Influence of diacylglycerol compounds on
metabolic cooperation between Chinese hamster V79 cells in vitro. Amer. Assoc. Cancer
Res. Mtg., Los Angeles, May 1986.
99. El-Fouly, M.H., S.T. Warren, J.E. Trosko and C.C. Chang: "Inhibition of gap-junction
mediated intercellular communication in cells transfected with the human H-ras
oncogene. Amer. Soc. Human Genetixs, Pennsylvania, Nov., 1986.
100. Trosko, J.E., C.C. Chang, M.H. El-Fouly, R. Kulkarni and R. Gera: "Role of gap junctional
intercellular communication in the regulation of growth and differentiation of normal and
malignant human epithelial cells. 4th Decennial International Tissue Culture Assoc.
Mtg., Hershey, PA, Sept. 22- 26, 1986.
101. Evans, M.G., M.H. El-Fouly and J.E. Trosko: "Application of the scrape- loading/dye
transfer assay to determine dose/response of 2,4,5-2',4',5' Hexabromobiphenyl on
42
102.
103.
104.
105.
106.
107.
108.
109.
110.
111.
112.
113.
114.
115.
inhibition of gap junctional intercellular communication in vitro”. Amer. College of Vet.
Path., New Orleans, Dec. 1- 5, 1986.
Chang, C.C., I. Matsumura and J.E. Trosko: "Selective lack of gap junctional intercellular
communication in a human teratocarcinoma cell line and in human cell lines derived
from an osteosarcoma". Amer. Assoc. Cancer Res. Mtg., New Orleans, May 25-28,
1987.
Trosko, J.E. and C.C. Chang: "The emperor wears no clothes in the field of genetic
toxicology". Environ. Mutagen Society Mtg., Charleston, SC, March 27-31, 1988.
Bombick, D., G. Zhang and J.E. Trosko: "Cell type response to different chemical
modulators of gap junction function". Soc. of Toxicology.
El-Fouly, M.H., J.E. Trosko, C.C. Chang and G.P. Dotto: "Effects of Ca++, TPA and H-ras
oncogenes on gap junctional intercellular communication in primary epithelial cells".
Tissue Culture Assoc., Las Vegas, NV, June 12- 15, 1988.
El-Fouly, M.H., J.E. Trosko and C.C. Chang: "Phenotypic transformation and inhibition of
gap junctional intercellular communication by the neu oncogene". Tissue Culture Assoc.,
Las Vegas, NV, June 12-15, 1988.
Madhukar, B.V., S.Y. Oh, J. Quensen, M. Wade and J.E. Trosko: "Inhibition of
intercellular communication by heptachlor and heptachlor epoxide in a rat liver epithelial
cell line". Tissue Culture Assoc., Las Vegas, NV, June 12-15, 1988.
El-Fouly, M.H., J.E. Trosko, C. Nelson and G.P. Dotto: "Effects of Ca++, TPA, and H-ras
oncogene on gap junction intercellular communication in primary epithelial cells". 4th
Ann. Meeting on Oncogenes, Frederick, MD, July 5-9, 1988.
El-Fouly, M.H., J.E. Trosko and C.C. Chang: "Phenotypic transformation and inhibition of
gap junctional intercellular communication in epithelial and mesenchymal cells by the
neu oncogene. 4th Ann. Meeting on Oncogenes, Frederick, MD, July 5-9, 1988.
Li, E.I., Y.S. Jou, C.C. Chang and J.E. Trosko: "Development of sensitive in vitro human
cell assays to detect mutagens”. Tissue Culture Assoc., In Vitro Cell. Devel. Biol.
25:19A, 1989. (Orlando, FL, June 11, 1989).
Chang, C.C., J.E. Trosko and C.W. Welsch: "Selection of human breast and kidney
epithelial cells with extended life span and contact insensitivity". AACR Meeting, San
Francisco, CA, May, 24-27, 1989, Cancer Res. 30:150, 1989.
Madhukar, B.V., S.Y. Oh, E. de Feijter and J.E. Trosko: "Inhibition of intercellular
communication by toxic xenobiotic chemicals in vitro in a human epithelial cell system".
Soc. of Toxicology, Atlanta, GA, Feb. 27-March 3, 1989. The Toxicologist 9:4, 1989.
Lilly, S.G., E. de Feijter, C.M. Weghorst, C.C. Chang, B.V. Madhukar, M. El-Fouly, J.E.
Trosko and J.E. Klaunig: "Reduced gap junctional intercellular communication and
tumorigenicity of rat liver epithelial F344-WB cells". Soc. of Toxicol., Atlanta, GA, Feb.
27-March 3, 1989. The Toxicologist 9:123, 1989.
Jou, Y.S., C.C. Chang and J.E. Trosko: "Development of a sensitive human epithelial cell
line for mutagen screening". 5th Intern. Conf. Environmental Mutagens, Cleveland, OH,
July 10-15, 1989.
Trosko, J.E.: "Mechanisms of chemical and oncogene modulation of gap junction and
communication during carcinogenesis", Workshop on the Molecular and Cell Biology of
Gap Junctions, Irsee, Germany, July 18-23, 1989.
43
116. Trosko, J.E., C.C. Chang and B.V. Madhukar: "In vitro analysis of modulators of
intercellular communication: Implication to mechanisms of tumor promotion and to
predictions of potential tumor promoters". 2nd Intern. Conf. on Practical In Vitro
Toxicology, Nottingham, U.K., July 23-27, 1989.
117. Trosko, J.E., J.E. Klaunig, B.V. Madhukar, C.C. Chang, E. de Feijter and G. Kalimi:
"Chemical and oncogene modulation of intercellular communication during
carcinogenesis". Symposium on Molecular Cell Biology of Liver Growth and Function,
Lake Placid, NY, Aug. 13-16, 1989.
118. Hasler, C.H., M.R. Bennink and J.E. Trosko: "Changes in the fatty acyl composition of
membrane phospholipids are associated with modulation of gap junctional intercellular
communication in rat liver epithelial cells”. Soc. of Toxicol., Miami Beach, Feb 12-16,
1990.
119. Madhukar, B.V., H. Hong Hsu, B. Lockwood and J.E. Trosko: "Inhibition of intercellular
communication by environmental chemicals in rat leydig cells in vitro. Soc. of Toxicol.,
Miami Beach, Feb. 12-16, 1990.
120. Paradee, W.J., B.V. Madhukar and J.E. Trosko: "Mezerein inhibition of intercellular and
activation of protein kinase C in human kidney epithelial cells”. Soc. of Toxicol., Miami
Beach, Feb. 12-16, 1990.
121. de Feijter, A.W., M.W. Lieberman and J.E. Trosko: "Up-regulation of a metallothionein
Ras T24 fusion gene in rat liver epithelial cells is correlated with the down regulation of
gap junction function”. Soc. of Toxicol., Miami Beach, Feb. 12-16, 1990.
122. Trosko, J.E. and M. Wade: "Roles of oncogenes and chemicals in intercellular
communication and carcinogenesis: Quantitative and fluorescence analysis using the
ACAS 570 interactive laser cytometer”. Cell Biol. Mtg., Houston, TX, Nov. 8, 1989.
123. Trosko, J.E., B.V. Madhukar, H. Xu, E. Dupont and C.C. Chang: "Modulated gap
junctional communication as a biomarker for the multiple toxicities of pesticides”. NIEHS
Conference, "Agricultural Chemicals Utilization and Human Health”. Research Triangle
Park, NC, July 12-13, 1990.
124. Kalimi, G., C.C. Chang, P. Edwards, E. Dupont, B.V. Madhukar, E. Stanbridge and J.E.
Trosko: "Re-establishment of gap junctional communication in a non-tumorigenic Helahuman fibroblast hybrid”. Proc. Amer. Assoc. Cancer Res. 31:318, 1990.
125. Kalimi, G., J.E. Trosko, L.L. Hampton, S.S. Thorgeirsson and A.C. Huggett: "Gap
junctional intercellular communication in raf and raf/myc transformed rat liver epithelial
cell lines”. Proc. Amer. Assoc, Cancer Res. 31:132, 1990.
126. Chang, C.C., S. Nakatsuka, Kalimi, G., J.E. Trosko and C.W. Welsch: "Characterization of
two types of normal breast epithelial cells that are either deficient or proficient in gap
junctional intercellular communication”. J. Cell. Biochem. 14B:331, 1990.
127. Jou, Y.S., C.C. Chang and J.E. Trosko: "Development of a sensitive human cell line for
mutagen screening. Tests on Topoisomerase II effectors”. Environ. Molec. Mutagenesis
19:35, 1991.
128. Rupp, H.L., J.E. Trosko and B.V. Madhukar: "Protein kinase C translocation during
mezerein-inhibited intercellular communication in vitro”. Society of Toxicology, Dallas,
TX, February 25-March 1, 1991.
44
129. Madhukar, B.V., H.L. Rupp, W.J. Paradee and J.E. Trosko: "Xenobiotic modulation of
gap junctional communication of rat pancreatic epithelial cells in vitro”. Society of
Toxicology, Dallas, TX, February 25-March 1, 1991.
130. Jou, Y.S., C.C. Chang and J.E. Trosko: "Development of a sensitive human cell line for
mutagen screening--tests on topoisomerase II effectors”. Environmental Mutagen
Society Annual Meeting, Orlando, FL, April 6-11, 1991.
131. Chang,C.C., C.Y. Kao, S. Nakatsuka, J.E. Trosko and C.W. Welsch: "Identification of a
subpopulation of normal human breast epithelial cells with stem cell characteristics”.
AACR, Houston, TX, May 15-18, 1991.
132. Dupont, E., A.W. de Feijter, J.E. Trosko, J.P. Briand and B.V. Madhukar: "Suppression of
gap junction gene expression by growth factors and TPA in human epidermal
keratinocytes in vitro”. International Gap Junction Meeting, Asilomar, CA, June 9-13,
1991.
133. Kulkarni, R., B.V. Madhukar, C.C. Chang, J.E. Trosko and N. Dimitrov: "Decreased efflux
of adriamycin by verapamil in adriamycin resistant MCF-7 human breast tumor cells: A
laser cytometric analysis”. Michigan Regional Chapter of American Cancer Society,
Detroit, MI, September 1991.
134. Madhukar, B.V., B. Lockwood, H.L. Rupp and J.E. Trosko: "Transient exposure of rat
liver epithelial cells to TPA delays desensitization to the tumor promoter effect on
intercellular communication”. Society of Toxicology, Seattle, WA, February 23-27, 1992.
135. Trosko, J.E., B.V. Madhukar, H.L. Rupp, E. Dupont and B. Lockwood: "A human
endothelial primary cell culture model to study gap junction protein and function:
Chemical modulation of gap junctional intercellular communication”.
Society of
Toxicology, Seattle, WA, February 23-27, 1992.
136. Dupont, E., B.V. Madhukar, H.L. Rupp and J.E. Trosko: "Non-genotoxic interactions of
xenobiotics with primary human epidermal cells in vitro: Down-regulation of gap
junctional communication”. Society of Toxicology, Seattle, WA, February 23-27, 1992.
137. Lockwood, B., B.V. Madhukar, H.L. Rupp and J.E. Trosko: "Human mammary epithelial
cells as an in vitro model to study xenobiotic modulation of gap junctional
communication”. Society of Toxicology, Seattle, WA, February 23-27, 1992.
138. Rupp, H.L., B.V. Madhukar and J.E. Trosko: "Differential translocation of protein kinase
C isozymes by tumor promoters in primary cultures of human mammary epithelial cells An immunofluorescence analysis”. Society of Toxicology, Seattle, WA, February 23-27,
1992.
139. de Feijter, E., E. Dupont, H.L. Rupp, B.V. Madhikar and J.E. Trosko: "Thapsigargin, but
not TPA, dieldrin or heptachlor epoxide, down-regulates connexin 43 gap junction gene
expression in rat pancreatic epithelial cells in culture”. Society of Toxicology, Seattle,
WA, February 23-27, 1992.
140. Kao, C.Y., R. Zhou, C. Oakley, J.E. Trosko, C.W. Welsch and C.C. Chang: "A systematic
method to extend the lifespan of human breast epithelial cells in vitro”. American
Association for Cancer Research, San Diego, CA, May 20-23, 1992.
141. Kulkarni, R., B.V. Madhukar, H. Rupp, C.C. Chang, J.E. Trosko, L. Charmella and N,
Dimitrov: "Increased retention of Adriamycin by a protein kinase C inhibitor, Calphostin
C, in resistant MCF-7 human breast tumor cells”. American Association of Cancer
Research, San Diego, CA, May 20-23, 1992.
45
142. Matesic, D.F., H.L. Rupp, J.E. Trosko and B.V. Madhukar: "Inhibition of intercellular
communication by tumor promoting chemicals: Correlation with changes in gap junction
(connexin) messenger RNA levels”. Society of Toxicology, New Orleans, LA, March 1418, 1993.
143. Madhukar, B. Lockwood and J.E. Trosko: "A tumor promoter, thapsigargin, elevates
intracellular free calcium levels in cultured rat pancreatic epithelial cells”. Society of
Toxicology, New Orleans, LA, March 14-18, 1993.
144. Lockwood, B.V. Madhukar and J.E. Trosko: "Elevation of intracellular calcium levels and
inhibition of cell-cell communication in rat liver epithelial cells by thapsigargin”. Society
of Toxicology, New Orleans, LA, March 14-18, 1993.
145. Schafer, L.D., K. Sigler, W.J. Bonney, E. Dupont, J.E. Trosko and R.J. Ruch: "Reduced
gap junctional area in tumor promoter-treated cells”. Society of Toxicology, New
Orleans, LA, March 14-18, 1993.
146. Lu, S.C., B.V. Madhukar and J.E. Trosko: "Transformation of WB rat liver epithelial cells
with v-raf oncogene downregulates gap junctional communication and alters TPA
responsiveness”. American Assoc. of Cancer Research, Orlando, FL, May 19-22, 1993.
147. Yang, T.T., C.Y. Kao, Y.S. Jou, E. Dupont, B.V. Madhukar, J.E. Trosko, C.W. Welsch and
C.C. Chang: "Expression of gap junction genes in two types of normal human breast
epithelial cells and breast cancer cell lines”. American Association of Cancer Research,
Orlando, FL, May 19-22, 1993.
148. Kao, C.Y., K. Nomata, C. Oakley, J.E. Trosko, C.W. Welsch and C.C. Chang:
"Transformation of two types of normal human breast epithelial cells by SV40 large Tantigen”. American Association of Cancer Research, Orlando, FL, May 19-22, 1993.
149. Trosko, J.E., T.T. Yang, K. Nomata, C.Y. Kao and C.C. Chang: "Characterization of gap
junctional communication in normal human breast epithelial cells and in breast cancer
cells transformed with various connexin genes”. International Gap Junction Meeting,
Hiroshima, Japan, August 24-27, 1993.
150. Kao, C.Y., K. Nomata, C. Oakley, J.E. Trosko, C.W. Welsch and C.C. Chang: "Role of
differentiation in neoplastic transformation of normal human epithelial cells”.
International Symposium on Molecular Mechanisms of Radiation and Chemical
Carcinogen-induced cell transformation. Mackinac Island, MI, Sept. 19-23, 1993.
151. Ruch, R.J., C. Esinduy, C.C. Chang, J.E. Trosko: "Role of gap junctional intercellular
communication in the growth inhibition of transformed cells by non-transformed cells”.
Proc. Amer. Cancer Res., 35:89, 1994.
152. Kao, C.Y., C.S. Oakley, J.E. Trosko, C.W. Welsch and C.C. Chang:
"Further
characterization of two types of normal human breast epithelial cells”. Proc. Am. Assoc.
Cancer Res., 35:16, 1994.
153. Hayashi, T., C. Kim, K. Nomata, C.C. Chang and J.E. Trosko: "Differential DNA
methylation in gap junction gene for cx 43 in normal and tumorigenic human breast
epithelial cells”. Proc. Amer. Assoc. Cancer Res., 35:560, 1994.
154. Esinduy, C., C.C. Chang, J.E. Trosko and R.J. Ruch: "Growth inhibition of transformed
cells by nontransformed cells:
Requirement for a gap junctional intercellular
communication”. The Toxicologist, 14:57, 1994.
155. Matesic, D.F., R.J. Ruch, H. Rupp, J. Wagner, C.C. Chang and J.E. Trosko: "Mechanisms
in epigenetic toxicology: Two classes of tumor promoters that inhibit gap junctional
46
156.
157.
158.
159.
160.
161.
162.
163.
164.
165.
166.
167.
168.
169.
170.
intercellular communication (GJIC) induce either hyper- or hypo-phosphorylation of
connexin 43”. Toxicologist, 14:57, 1994.
Matesic, D.F., T. Hayashi J.E. Trosko and J.A. Germak: "Modulation of gap junctional
intercellular communication in cultured LHRH neurons". Society of Neuroscience, 1995.
Kang, K.-S., M.R. Wilson, T. Hayashi, C.C. Chang and J.E. Trosko: "Effect of several
environmental pollutants presented as a food residue on gap junctional intercellular
communication in normal human breast epithelial cells". The Toxicologist, 274, 1995.
Hayashi, T., C.C. Chang, D.F. Matesic, K.-S. Kang and J.E. Trosko: "Stimulation of cell
proliferation and inhibition of intercellular communication by linoleic acid". Proc. Amer.
Assoc. Cancer Res. 36:178, 1995.
Hayashi, T., K. Nomata, D. Matesic, K.-S. Kang, C.Y. Kao, L. Lockwood, C.C. Chang and
J.E. Trosko: "Inhibition of gap junctional intercellular communication in heptachlor or
heptachlor epoxide treated normal human breast epithelial cells". The Toxicologist
15:274, 1995.
Rupp, H.L. and J.E. Trosko: "Acrylonitrile inhibition of gap junctional intercellular
communication in rat liver epithelial and rat glial cells". The Toxicologist 15:274, 1995.
Upham, B.L., J.J. Yao, J.E. Trosko and S.J. Masten: "Determination of the efficacy of
ozone treatment systems using a gap junction intercellular communication bioassay".
The Toxicologist 15: 273, 1995.
Madhukar, B.V., R.A. Little, J.E. Klaunig and J.E. Trosko: "Activation of protein Kinase C
alpha (PKC-a) and inhibition of intercellular communication by polychlorinated biphenyls
(PCB) in rat liver epithelial cells". The Toxicologist 15:28, 1995.
Trosko, J.E.: "Gap junctional communication for drug discovery and development". The
Toxicologist 15:289, 1995.
Wilson, M.R., W.B. Coleman, C.C. Chang and J.E. Trosko: "Altered differentiation and
gap junctional intercellular communication in v-src transformed rat liver cells". Proc.
Amer. Assoc. Cancer Res. 36:562, 1995.
Kang, K.-S., I. Morita, C.J. Liu, J.E. Trosko and C.C. Chang: "Expression of a variant
estrogen receptr in a normal human breast epithelial cell (HBEC) type and SV40
transformed HBEC". Proc. Amer. Assoc. Cancer Res. 37:38, 1996.
Chang, C.C., C.J. Liu, N.D. DeoCampo, K.-S. Kang and J.E. Trosko: "The unique ability
of a normal human breast epithelial cell type with stem cell and luminal epithelial cell
characteristics to form budding and ductal structure in Matrigel matrix". Proc. Amer.
Assoc. Cancer Res. 37:235, 1996.
DeoCampo, N.D., B.L. Upham and J.E. Trosko:
"The role of gap junctional
communication in the toxicity of quadricyclane, perfluorode canoic acid, perfluoroctanoic
acid and jet fuels, JP-8 and JP-4". The Toxicologist 30:208, 1996.
Upham, B.L., L.M. Weis, A.M. Rummel, S.J. Masten and J.E. Trosko: "The biological
effects of methylated anthracenes on gap junctional intercellular communication
depends on the ring position of the methyl group. The Toxicologist 30:208, 1996.
Kwon, M.S., K.-S. Kang, J.A. Hotchkiss, J.E. Trosko and J.R. Harkema: "Cigarette
smoke-induced alteration in the expression of gap junction proteins in rat nasal
epithelium". ACS symposium, Michigan State University, East Lansing, Nov. 17, 1995.
Chang, C.C., K.-S. Kang, C.Y. Kao, C.J. Liu and J.E. Trosko: "A normal human breast
epithelial cell type with stem cell characteristics is more susceptible to neoplastic
47
171.
172.
173.
174.
175.
176.
177.
178.
179.
180.
181.
transformation". World Congress on In Vitro Biology, San Francisco, CA, June 22-27,
1996.
Holland, M.S., M.R. Wilson, R.F. Silva, and J.E. Trosko: “Comparison of gap junction
intercellular communication in cells infected with Marek's Disease Virus serotype 1, 2, or
3”. Annual Meeting of the AVMA, Louisville, Kentucky, July 21-24, 1996.
Trosko, J.E.: "Is the gap junction the 'Biological Rosetta Stone' for understanding
genetic and environmental influences on many human diseases?" Cellular and Molecular
Biology, 2nd World Congress, Ottawa, Canada, Sept. 4, 1996.
Jouishomme, H., M. Phipps, S. Lucelle and J.E. Trosko: "Tissue homeostasis and
intercellular communication". 2nd World Congress on Cellular and Molecular Biol.,
Ottawa, Canada, Sept. 4, 1996.
Upham, B.L., H. Cho and J.E. Trosko: "Hydrogen peroxide inhibits gap junctional
intercellular communication in glutathione sufficient but not glutathione deficient cells".
Forum on Environ. Remediation and Environmental Toxicol., Lansing, MI, Sept. 19,
1996.
Weis, L.M., B.L Upham, A.M. Rummel, S.J. Masten and J.E. Trosko: "Determining a
correlation between structural elements of polycyclic aromatic hydrocarbons and
inhibition of gap junctional intercellular communication".
Forum on Environ.
Remediation and Environ. Toxicology, Lansing, MI, Sept. 19, 1996.
Holland, M.S., R.F. Silva, J.E. Trosko and M.R. Wilson: "Differences in gap junctional
intercellular communication between cells infected with either attenuated or oncogenic
Marek's disease virus”. 5th International Symposium on Marek's Disease, East Lansing,
Michigan, September 7-11, 1996.
Carruba, G., M.M. Webber, D. Bello, N.D. DeoCampo, J.E. Trosko and L. Castagnetta:
“Laser scanning analysis of cell-cell communication in human prostate epithelial cells”.
10th International Conf. Diagnostic Quantitative Pathology, Sendai, Japan, Nov. 1996.
Holland, M.S., M.R. Wilson, R.F. Silva, and J.E. Trosko: “Alteration of gap junction
intercellular communication in cells infected with oncogenic Marek's Disease virus”.
American Cancer Society 7th Annual Research Conference, Ann Arbor, Michigan,
November 22, 1996.
Wilson, M.R., T.W. Close, N.D. DeoCampo and J.E. Trosko: "Alterations of gapjunctional intercellular communication during induction of apoptosis in normal and
oncogene transformed cells". 6th International Cong. Cell Biol. 36th Amer. Soc. Cell
Biol. San Francisco, Dec. 7-11, 1996.
Upham, B.L., K.-S. Kang, N.D. DeoCampo, H. Choal and J.E. Trosko: "Perfluorinated
fatty acids of specific chain lengths directly inhibit gap junctional intercellular
communication and indirectly inhibit via H2O2 in glutathione-sufficient but not
glutathione-deficient cells". AFOSR Toxicology Program Review, Fairborn, OH, Dec. 1213, 1996.
Upham, B.L., L.M. Weis, J.J. Yao, S.M. Masten and J.E. Trosko: "Predicting the
structural elements of different polycyclic aromatic hydrocarbons that are toxic at the
epigenetic level as determined by assaying gap junctional intercellular communication
before and after environmental remediation". NIEHS-Superfund Program Review,
February, 1997.
48
182. Ruch, R.J., R.S. Rae, P.P. Mehta and J.E. Trosko: "Liver tumor suppressing activity of a
gap junction protein gene, connexin 32". Soc. Toxicol., Cincinnati, OH, March 7-13,
1997.
183. Kang, K.-S., J.E. Trosko and C.C. Chang: "Telomerase activity in a normal human breast
epithelial cell type with stem cell characteristics and its neoplastically transformed cells".
AARC Meeting, San Diego, CA, April 12-16, 1997.
184. Kang, K.-S., K. Nomata, I. Morita, A. Cruz, J.E. Trosko and C.C. Chang: "Involvement of
tyrosine phosphorylation of p185CerB-2/neu in tumorigenicity induced by x-rays and neu
oncogene in human breast epithelial cells". AARC Meeting, San Diego, CA, April 12-16,
1997.
185. Kang, K.-S., A. Cruz, J.E. Trosko and C.C. Chang: "BRCA-1 was not expressed in a
normal human breast epithelial cell type with stem cell characteristics”. AARC Meeting,
San Diego, CA, April 12-16, 1997.
186. Upham, B.L., L.M. Weis, J.J. Yao, S.M. Masten and J.E. Trosko: “Predicting the
structural elements of different polycyclic aromatic hydrocarbons that are toxic at the
epigenetic level as determined by assaying gap junctional intercellular communication
before and after environmental remediation”. NIEHS-Superfund Program Meeting,
Research Triangle Park, NC, Feb. 24-27, 1997.
187. Ruch, R.J., R.S. Rae, P.P. Mehta and J.E. Trosko: “Liver tumor suppressing activity of a
gap junction protein gene”. SOT Meeting, Cincinnati, Ohio, March 9-13, 1997.
188. Weis, L.M., B.L. Upham, A.M. Rummel, S.J. Masten and J.E. Trosko: “Determining a
correlation between structural elements of polycyclic aromatic hydrocarbons and
inhibition of gap junctional intercellular communication”. SOT Meeting, Cincinnati, Ohio,
March 9-13, 1997.
189. Trosko, J.E.: “EMF-induced epigenetic events in risk assessment”. NIEHS EMF Science
Review Symposium, Research Triangle Park, NC, March 24-27, 1997.
190. Wilson, M.R. and J.E. Trosko: “A role for mitogen-activated protein (MAPK) during rasinduced down-regulation of gap junctional intercellular communication”.
1997
International Gap Junction Conference, Key Largo, Florida, July 12-17, 1997.
191. Holland, M., R. Silva, J.E. Trosko and M.R. Wilson: “Aberrant gap junction intercellular
communication of cells infected with oncogenic Marek’s Disease virus”.
1997
International Gap Junction Conference, Key Largo, Florida, July 12-17, 1997.
192. Wilson, M.R. and J.E. Trosko: “The balance between birth and death: Apoptosis,
mitosis, and gap junctions 1997 International Gap Junction Conference, Key Largo,
Florida, July 12-17, 1997.
193. Upham, B.L., M.R. Wilson, T. Koski, L.M. Weis, N.D. DeoCampo and J.E.Trosko: “Small
structural changes in compounds such as PAHs, ceramide or perfluorinated fatty acids
greatly alter the potency of inhibition on gap junctional intercellular communication”.
1997 International Gap Junction Conference, Key Largo, Florida, July 12-17, 1997.
194. Trosko, J.E.: “Can non-ionizing radiation ‘cause’ cancer?” Symposium on “Mobile
Phones: Is There A Health Risk?” Brussels, Belgium, Sept. 16-17, 1997.
195. Trosko, J.E.: “Significance of intercellular communication mechanisms in radiation and
chemical risk assessments”. International conference on “Health Effects of Low Level
Exposure: Scientific Developments and Perspectives for Risk Assessment”. Utrecht,
Netherlands, Oct. 19-21, 1997.
49
196. Trosko, J.E.: “Modulation of gap junctional communication during carcinogenesis by
tumor promoters, growth factors, and oncogenes:
An integrative theory of
carcinogenesis”. Symposium on “IL Carcinoma della Prostata”. Bologna, Italy, Nov. 2629, 1997.
197. Trosko, J.E.: “Modulation of gap junctional intercellular communication, disrupted
homeostasis, and epigenetic toxicology”. Society of Toxicology, Seattle, Washington,
March 1-5, 1998.
198. Dowling, C. and J.E. Trosko: “Induction of gap junctional communication and
differentiation in a human neuronal cell line”. Experimental Biology ’98 Meeting, San
Francisco, CA, April 18-22, 1998.
199. Chang, C.C., C.-Y. Hsieh, A. Cruz, S. Wei and J.E. Trosko: “Human breast epithelial stem
cells as targets for carcinogenesis and chemoprevention”. 22nd Congress of the
International Association for Breast Cancer Research, Athens, Greece, September 25-28,
1998.
200. Upham B.L., A.M. Rummel, M.R. Wilson and J.E. Trosko: “Polycyclic aromatic
hydrocarbons with bay-like regions inhibited gap junctional intercellular communication
and induced the activation of MAPK”. Society of Toxicology, New Orleans, LA, March
14-18, 1999.
201. Sun, W., K.S. Kang, J.E. Trosko and C.C. Chang: “A normal human breast epithelial cell
(HBEC) type with stem cell characteristics is more susceptible to telomerase activation
and immortalization”. AACR Annual Meeting, Philadelphia, PA, April 10-14, 1999.
202. Holland, M.S. and J.E. Trosko: “Regulatory control of cell to cell communication by
tumor suppressor genes”. Professional Development and Peer Review Workshop,
National Institutes of Health, NCI, Bethesda, MD, May 3-4, 1999.
203. Trosko, J.E.: “Modulation of cell-cell communication in the cause and prevention of
cancer”. International Conference on Diet and Prevention of Cancer, Tampere, Finland,
May 28-June 2, 1999.
204. Trosko, J.E.: “Human health consequences of environmentally-modulated altered
gene expression: Epigenetic versus mutagenic mechanisms of disease”. 21 st Annual
Meeting of The Bioelectromagnetics Society (BEMS), Long Beach, CA, June 20-24,
1999.
205. Chang, C.C., C.Y. Hsieh, W. Sun, C.J. Liu, M. Saitoh and J.E. Trosko: “Role of ionizing
radiation in neoplastic transformation of human breast epithelial cells (HBEC)”. 11th
International Congress of Radiation Research, Dublin, Ireland, July 20-22, 1999.
206. Trosko, J.E. and C.C. Chang: “Gap junctional intercellular communication as a
modulator of radiation-induced epigenetic effects”. 11th International Congress of
Radiation Research, Dublin, Ireland, July 20-22, 1999.
207. Trosko, J.E.: “The discovery of a ‘Biological Rosetta Stone’: Its implications for
radiation and chemical-induced carcinogenesis”.
11th International Congress of
Radiation Research, Dublin, Ireland, July 20-22, 1999.
208. Chang, C.C., W. Sun, K.S. Kang and J.E. Trosko: “A normal human breast epithelial
cell (HBEC) type with stem cell characteristics is more susceptible to telomerase
activation and immortalization”. Satellite In Vitro Human Cell Transformation Meeting,
Cork, Ireland, July 24-26, 1999.
50
209. Trosko, J.E. and C.C. Chang: “Role of stem cells and gap junctional communication in
human carcinogenesis”. Satellite In Vitro Human Cell Transformation Meeting, Cork,
Ireland, July 24-26, 1999.
210. Ghoshal, S., B.L. Upham, A.M. Rummel, J.E. Trosko and W.J. Weber, Jr.: “Assessment
of the epigenetic toxicity of a mixture of polycyclic aromatic hydrocarbons before and
after biodegradation”. 1999 ASCE-CSCE National Conference on Environmental
Engineering, Norfolk, VA, July 25-28, 1999.
211. Suzuki, J., B.L. Upham, L. McCabe, C.C. Chang, V. Kurutovskikh, H. Yamasaki and J.E.
Trosko: “Modulation of differentiation by transfected dominant-negative connexin 43
in mouse osteoblast cell clones”. 1999 International Gap Junction Conference, Gwatt,
Switzerland, August 28-Sept. 2, 1999.
212. Trosko, J.E. and C.C. Chang: “Gene regulation in pluripotent human stem cells”.
Workshop on Computational and Theoretical Biology, Michigan State University, April
24, 1999.
213. Trosko, J.E.: “Cloning of human stem cells: Scientific, therapeutic, philosophical and
ethical issues”. American Fed. Medical Res., Chicago, Illinois, Sept. 17, 1999.
214. Trosko, J.E.: “Epigenetic toxicology: A unifying paradigm with mechanistic and risk
assessment implications”. Epigenetic Toxicant-Induced Signal Transduction and
Altered Cell-Cell Communication Symposium, University of Michigan, October 17-20,
1999.
215. Wilson, M.R. and Trosko, J.E.: “Cell-cell interactions during apoptosis in adherent
epithelial cell populations”. Epigenetic Toxicant-Induced Signal Transduction and
Altered Cell-Cell Communication Symposium, University of Michigan, October 17-20,
1999.
216. DeoCampo, N.D. and J.E. Trosko: “Differential responses in connexin expression in a
series of normal and oncogene transfected cell lines treated with sodium butyrate”.
Epigenetic Toxicant-Induced Signal Transduction and Altered Cell-Cell Communication
Symposium, University of Michigan, October 17-20, 1999.
217. Upham, B.L., T.R. Koski, M.R. Wilson, A.D. Horvath, and J.E. Trosko: C2- and C6ceramides were potent inhibitors of gap junctional intercellular communication and
apoptosis whereas a C2-ceramide was a weak inhibitor of communication but a strong
inducer of apoptosis”. Epigenetic Toxicant-Induced Signal Transduction and Altered
Cell-Cell Communication Symposium, University of Michigan, October 17-20, 1999.
218. Upham, B.L., G. Chen, A. Voges, K. Sai, and J.E. Trosko: “The inhibition of gap
junctional intercellular communication and the activation of MAPK by methylated
anthracenes with specific structures”.
Epigenetic Toxicant-Induced Signal
Transduction and Altered Cell-Cell Communication Symposium, University of Michigan,
October 17-20, 1999.
219. Davis, J., B.L. Upham, J.E. Trosko, and K.A. Schwartz: “Inibition of gap junctional
intercellular communication in cardiac myocytes overloaded with iron”. Epigenetic
Toxicant-Induced Signal Transduction and Altered Cell-Cell Communication
Symposium, University of Michigan, October 17-20, 1999.
220. Chen, G., B.L. Upham, V. Krutovskikh, H. Yamasaki, and J.E. Trosko: “A dominant
negative Cx43 gene decreases the molecular weight cut off of gap junctions to 650
and inhibits differentiation”. Epigenetic Toxicant-Induced Signal Transduction and
51
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225.
226.
227.
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Altered Cell-Cell Communication Symposium, University of Michigan, October 17-20,
1999.
Upham, B.L., J.M. Carbone, L.-L. Li, A.M. Rummel, T. Lee, and J.E. Trosko:
“Resveratrol, an antioxidant found in red wine, prevented the inhibition of gap junction
intercellular communication by the tumor promoting agents dicumyl and benzoyl
peroxides”. Epigenetic Toxicant-Induced Signal Transduction and Altered Cell-Cell
Communication Symposium, University of Michigan, October 17-20, 1999.
Sai, K., J.E. Trosko, and T. Inoue: “Pentachlorophenol-induced down-regulation of
gap junctional intercellular communication was ameliorated by (-)-epigallocatechin
gallate in rat liver epithelial cells”. Epigenetic Toxicant-Induced Signal Transduction
and Altered Cell-Cell Communication Symposium, University of Michigan, October 1720, 1999.
Pickering, C.R., J.E. Trosko, B.L. Upham: “Inhibition of gap junctional intercellular
communication in rat liver epithelial cells by the signal transductant nitrous oxide”.
Epigenetic Toxicant-Induced Signal Transduction and Altered Cell-Cell Communication
Symposium, University of Michigan, October 17-20, 1999.
Na, H.-K. and J.E. Trosko: “Effect of ET-18-OCH3 and D609 (phospholipase c
inhibitors) on GJIC”. Epigenetic Toxicant-Induced Signal Transduction and Altered
Cell-Cell Communication Symposium, University of Michigan, October 17-20, 1999.
Holland, M.S. J.K. Golding, W.B. Coleman, and J.E. Trosko: “Regulation of gap
junction function in rat liver tumor microcell hybrid cell lines”. Epigenetic ToxicantInduced Signal Transduction and Altered Cell-Cell Communication Symposium,
University of Michigan, October 17-20, 1999.
Yao, J.J., S. Luster-Teasley, H. Herner, S. Masten and J.E. Trosko: “The effect of
ozone on the toxicity of chrysene and its byproducts”. Epigenetic Toxicant-Induced
Signal Transduction and Altered Cell-Cell Communication Symposium, University of
Michigan, October 17-20, 1999.
Trosko,
J.E.:
“Up-regulation
of
cell-cell
communication
in
the
chemoprevention/chemotherapy of cancer cells”. The Fourth Princess Chulabhorn
International Science Congress, Chemicals in the 21st Century, Bangkok, Thailand,
November 28-December 2, 1999.
Trosko, J.E.:
“Modulation of cell-cell communication for a strategy of
chemoprevention and chemotherapy of cancer”. International Congress on Food
Factors, Kyoto, Japan, Dec. 13-17, 1999.
Trosko, J.E., G. Chen, J. Suzuki, B.L. Upham, V. Krutovskikh, H. Yamasaki and C.C.
Chang:
“The effect of a dominant-negative connexin43 on gap junctional
communication and differentiation of several mammalial progenitor cell lines”. SOT
meeting, Philadelphia, Pennsylvania, March 19-23, 2000.
Saitoh, M., W. Sun, J.E. Trosko and C.C. Chang: “Co-transfection of a mutant p53 and
the human c-myc is an effective method to extend the lifespan of normal human
breast epithelial cells”. Proc. Am. Assoc. Cancer Res. AACR Annual Meeting, San
Francisco, CA, April 1-5, 2000.
Trosko, J.E.: “Modulation of gap junctional communication by ‘epigenetic’ toxicants: A
shared mechanism in teratogenesis, atherogenesis, carcinogenesis, reproductive-,
52
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235.
236.
237.
238.
239.
240.
241.
242.
243.
immuno- and neuro-toxicities”. International Conference on Arctic Development,
Pollution and Biomarkers of Human Health, Anchorage, Alaska, May 1-3, 2000.
Chang, C.C., W. Sun, C.-Y. Hsieh, M. Saitoh, M.-H. Tai, and J.E. Trosko: “A human
breast epithelial cell type with stem cell characteristics and estrogen receptor
expression as a target for carcinogenesis”. Department of Defense Breast Cancer
Research Program Meeting: Era of Hope, Atlanta, Georgia, June 8-12, 2000.
Rothwell, E.J., K.M. Chen, J. Suk, C.C. Chang, J.E. Trosko, G. Chen, B.L. Upham, and
W. Sun: “In vitro effects of 60 Hz magnetic fields on the differentiation and
proliferation of Friend leukemia cells”. IEEE AP-S International Symposium and URSI
Radio Science Meeting, Salt Lake City, Utah, July 16-21, 2000.
Trosko, J.E., C.C. Chang, and B.L. Upham:
“Gap junctional intercellular
communication: A biological ‘Rosetta Stone’ concept for understanding ‘epigenetic
toxicology’”. The 2nd Congress of the Asian Society of Toxicology ASIATOX II, Cheju
Island, Korea, August 23-25, 2000.
Trosko, J.E.:
“Cloning of human epithelial stem cells: their use in studying
mechanisms of normal development and therapeutic applications”. International
conference Antimutagenesis, Grand Rapids, Michigan, Sept. 23-27, 2000.
Saunders, M.M., J. You, J.E. Trosko, H. Yamasaki, H.J. Donahue, and C.R. Jacobs,
“Prostaglandin E2 response in MC3T3-E1 osteoblastic cells is dependent upon gap
junctional intercellular communication. Annals of Biomedical Engineering, pg. S-86.
Biomedical Engineering Society 2000 Annual Fall Meeting, Seattle, WA, Oct. 12-14,
2000.
Ogawa, T., T. Hayashi, N. Yorioka, and J.E. Trosko: “Comparative effect of glucose
and mannitol on cell-to-cell communication by human peritoneal mesothelial cells
(HPMC)”. Amer. Soc. Nephrology Meeting, Toronto, Canada, October 13-16, 2000.
Trosko, J.E.: “Role of stem cells and modulated gap junction intercellular
communication in the aging and carcinogenic processes”. Symposium on Aging and
Carcinogenesis, Nagasaki, Japan, November 14-15, 2000.
Trosko, J.E., K. Kwan, B.L. Upham, R. Halgren, T. Zacharewski, and C.C. Chang:
“Stem cell biology in toxicology”. SOT Meeting, San Francisco, CA, March 25-29,
2001.
Upham, B.L., A.M. Rummel, J.M. Carbone, J.E. Trosko, Y. Ouyang and N.E. Kaminski,
“Cannabinoids inhibited gap junctional intercellular communication and activated
extracellular receptor kinase in a rat liver epithelial cell line”. SOT Meeting, San
Francisco, CA, March 25-29, 2001.
Upham, B.L., J.E. Trosko, A. Hirose, R. Hasegawa, J. Kanno, T. Inoue and K. Sai,
“Structure-activity relationships of perfluorinated fatty acids on gap junctional
intercellular communication and MAPK using in vivo and in vitro model systems”. SOT
Meeting, San Francisco, CA, March 25-29, 2001.
C.C. Chang and J.E. Trosko, “Isolation and Characterization of normal human epithelial
pluripotent stem cells”. Oncology Research 12: 277, 2001. Stem Cell Differentiation,
Genetic Reprogramming and Programmed cell Death”, Santorini, Greece, Sept. 2-7,
2001.
Trosko, J.E., Y. Nakamura and B. Upham: “Dietary modulation of gap junction
communication, an epigenetic mechanism, during the rate-limiting step of the
53
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245.
246.
247.
248.
249.
250.
251.
252.
253.
254.
255.
initiation/promotion/progression process of carcinogenesis”.
8th International
Conference on Environmental Mutagens, Shizuoka, Japan, Oct. 21-26, 2001.
Ogawa, T., Hayashi, T., Yorioka, N., and Trosko, J.E., “ The PKC/ERK pathway might
not be the dominant regulator of intercellular communication by human peritoneal
mesothelial cells under high glucose conditions” 2001 ASN/ISN World Congress of
Nephrology
Trosko, J.E., “Scientific Concepts of Human Nature and Their Implication to Bioethics in
a Scientific and technologically-altered world”. Bioethics and Science in the New Epoch.
Conference in Mali Losinj, Croatia, Sept. 24-29, 2001.
Trosko, J.E., “ Dietary modulation of gap junctional communication during the rate
limiting step of the initiation /promotion/progression process of carcinogenesis”. 8th
International Congress on Environmental Mutagens. Shizuoka, Japan, Oct. 20-26, 2001.
Mutation Res. 483: S7, 2001.
J.E. Trosko, “Role of Human stem cells in understanding human aging and the diseases
of aging”. International Congress on Low Level Radiation Effects, Kagoshima, Japan,
November 9, 2001.
J.E. Trosko, “The role of human stem cells in the aging and diseases of aging process”.
Okinawa International Conference on Longevity”. Nago, Okinawa, Nov.11-13, 2001. J.
Okinawa Chubu Hosp. 27: 15, 2001.
Upham, B.L., Davis, J.M., Trosko, J.E., and Schwartz, K.A., “ Polycyclic Aromatic
hydrocarbons with bay-like structures inhibited gap junctional intercellular
communication in neonatal rat cardiomyocytes and caused asynchronous beating”. SOT
meeting, Nashville, 2002.
Reed, D., Tai, M.H., Olson, K., Madhukar, B.V., and Trosko, J.E., “Immortalized human
pancreatic ductal epithelial cells with stem cell characteristics”. Amer. College of
Surgeons Congress, San Francisco, Oct. 6-10, 2002.
Nakamura, Y., Trosko, J.E., Upham, B. “Up-regulation of gap junctional communication
by psyllium extracts decreased anchorage independent growth in ras-transformed rat
liver oval cells”. Soc. Toxicology, Nashville, Tenn., March 18-23, 2002.
Upham, B.L., Davis, J.M., Trosko, J.E., Schwartz, K.A., “ Polycyclic aromatic
hydrocarbons with bay-like structures inhibited gap junction intercellular communication
in neonatal rat cardiomyocytes and caused asynchronous beating”. Soc. Toxicology,
Nashville, Tenn., March 18-23, 2002.
Upham, B.L. and Trosko, J.E., “Inhibition of gap junctional intercellular communication
and the activation mitogen activated protein kinases by PCBs depends on substations of
Chlorine in the Ortho-Position.”, Soc. Toxicology, Nashville, Tenn., March 18-23, 2002.
Hu, W., Jones, P. D., Upham, B.L., Trosko, J.E., Lau, C., and Giesy, J.P.:” Inhibition of
gap junctional intercellular communication by Perfluorinated Compounds in Dolphin
kidney and Rat Liver Epithelial cell lines”. Soc. Toxicology, Nashville, Tenn., March 1823, 2002.
Teng, H.C., Cherng, S., Trosko, J.E., Chang, C.C., and Upham, B.L., Sensitivity of
osteoblast cells to inhibition of gap junctional intercellular communication by ELF-EMF at
14 Hz”. BEMS Quebec, Canada, June 24, 2002.
54
256. Trosko, J. E. “Molecular mechanisms of cellular toxicity of environmental toxicants
implicated in Balkan Endemic Nephropathy”. Internatl. Conference on Balkan Endemic
Nephropathy”. Michigan State University, Sept. 30- Oct. 2, 2002.
257. Tai, M.H., Olson, L.K., Madhukar, B.V., Tsao, M.S., Trosko, J.E., and Reed, D.N., Jr.,
“Immortalized human pancreatic ductal epithelial cells with stem-cell characteristics”. J.
Amer. Coll. Of Surgeons 195: 6, 2002.
258. Coe, C. King, K., Trosko, J.E., and Upham, B., “Anti-tumor promoting properties of betaglycyrrhetinic acid, an ingredient of black licorice”. Mich. Society of Toxicology, Michigan
State University, E. Lansing, November 1, 2002.
259. Upham, B.L., Titoh, P.K., and Trosko, J.E., “Specific isomers of methylated anthracenes
induce arachidonate-release, inhibit intercellular communication, and activate MAPK via
phosphatidylcholine PLC’. Mich. Society Toxicology, Michigan State University, East
Lansing, November 1, 2002.
260. Scott, J., Carbone, J.M., Rummel, A.M., Trosko, J.E., and Upham, B.L., “Resveratrol, an
antioxidant found in red wine, prevented the inhibition of gap junctional communication
and activation of MAPK by the tumor promoting agents dicumyl and benzoyl peroxides”.
Michigan Society of Toxicology, Michigan State University, East Lansing, November 1,
2002.
261. Tai, M.H., Upham, B.L., and J.E. Trosko, “Polycyclic aromatic hydrocarbons with bay-like
structures inhibited gap junctional intercellular communication in immortalized human
pancreatic cells”. Michigan Society of Toxicology, Michigan State University, November 1,
2002.
262. Tai, M.-H, Reed, D.N, Chang, C.C., and Trosko, J.E., “Role of pancreatic stem cells in the
emergence of pancreatic stellate cells and fibroblastic-like cells in chronic pancreatitis.”
Pancreatitis Study Section Meeting, Chicago; November 12, 2002.
263. Tai, M. H., Olson, l.K., Madhukar, B.V., Tsao, M.S., Trosko, J.E., and Reed, D.,
“Characterization of immortalized human pancreatic ductal epithelial cells with stem cell
characteristics. American Pancreatic Association Mtg, Chicago, November 14, 2002.
264. B.L. Upham, P.K. Tithof and J.E. Trosko, “The role of phosphatidylcholine PLC in the
inhibition of gap junction communication, activation of MAPK, and the release of
arachidonic acid by specific isomers of methylated anthracenes”. Society of Toxicology
meeting in Salt Lake City, March 9-13, 2003.
265. Y. Nakamura, Chang, C.C., Mori, T., Sato, K., K. Ohtsuki, B.L. Upham, and J.E. Trosko,
“Induction of differentiation by kaempherol in GJIC-sufficient but not GJIC-deficient
Colon cancer cells”. Society of Toxicology meeting in Salt Lake City, March 9-13, 2003.
266. M.H. Tai, B.L. Upham, and J.E. Trosko, “Polycyclic aromatic hydrocarbons with bay-like
structures inhibited gap junctional intercellular communication in immortalized human
pancreatic ductal epithelial cells”. Society of Toxicology meeting, Salt Lake City, March
9-13, 2003.
267. T. Yamada, L.D. Burgoon, K. Y. Kwan, M.R. Felden, J.E. Trosko, and T. R.
Zacharewski, “ Temporal gene expression profiles of human fetal astrocytes treated
with a neurotoxicant, 6-aminonicotinamide”. Society of Toxicology meeting, Salt Lake
City, March 9-13, 2003.
55
268. L.D. Burgoon, K.Y. Kwan, J.E. Trosko, and T. R. Zacharewski, “C-AMP and retinoid acid
induced differentiation of human SVG cells: Morhologic and transcriptional effects”.
Society of Toxicology meeting, Salt Lake City, March 9-13, 2003
269. J.E. Trosko, “ Overview on the interplay between genetics and epigenetic
abnormalities in cancer” Society of Toxicology Education Course, Salt Lake City,
February 9, 2003
270. J.E. Trosko “Use of Adult Pluripotent stem cells to screen for genotoxic/epigenetic
toxicants”, Society of Toxicology, Salt Lake City, March 10, 2003.
271. J.E. Trosko, Symposium address for Dr. Robert Hollingworth’s International Award
Ceremony:
“Epigenetic
toxicant-induced
modulation
of
cell-cell
communication/pesticides/risk assessment: Different mechanisms but all roads lead to
Rome”. Amer. Chem. Soc., New Orleans, March 24, 2003.
272. J. E. Trosko, “Human stem cells as the target for the aging and the diseases of aging”.
Dept. Pediatrics and Human Development Research Day, May 30, 2003, MSU, East
Lansing.
273. M.H. Tai, D.N. Reed, C.C. Chang, and J.E. Trosko, “Role of pancreatic stem cells in the
emergence of pancreatic stellate cells and fibroblast-like cells in chronic pancreatitis”.
Pediatrics and Human Development Research Day Symposium, May 30, 2003, MSU,
East Lansing.
274. J.E. Trosko, “Stem cells, cell-cell communication and epigenetic toxicants: Risk
assessment implications”. 2003 Congress on In Vitro Biology, Portland, Oregon, June
2, 2003.
275. J.E. Trosko, C.C. Chang, Mei-Hu Tai and B.L. Upham, “The role of stem cells and cellcell communication in cancer chemoprevention strategies”.
ICMAA-VII, 8Th
International conference on mechanisms of anti-mutagenesis and anticarcinogenesis.
Pisa, Italy, October 4-8, 2003.
276. J.E. Trosko, “Ignored hallmarks of carcinogenesis: Stem cells and cell-cell
communication” , International Course on “ Signal Transduction and communication in
cancer cells”. Erice, Sicily, October 24-31, 2003.
277. M.S. Holland, L.F. Griffin, J.E. Trosko, and R.E. Holland, “Ontogeny of bovine
mammary gland progenitor cells”. Tuskegee University Medical Symposium, March 36, 2003.
278. M.H. Tai, D.N. Reed, C.C. Chang, and J.E. Trosko, “Role of pancreatic stem cells in the
emergence of pancreatic stellate cells and fibroblast-like cells in chronic pancreatitis.
American Pancreatic Association mtg., Chicago, Ill., Nov. 6-7, 2003.
279. Trosko, J.E., Tai, M.-H., Chang, C.C., Olson, L.K., Lin, T.M., Madhukar, B.V. Expression
of Oct-4 and lack of gap junctional intercellular communication as “hallmarks” for
human adult stem cells and cancer cells. AACR Mtg, Orlando, Fl. March. 27-31, 2004.
280. J.L. Tsai, C.C. Chang, K.K. Kuo, K. Hung Wang, C.H. Chiang, A. P.Kao, M.H. Tai and
J.E. Trosko, Expression of Oct-4, alpha fetoprotein and vimentin, and the lack of gap
junctional intercellular communication (GJIC) as common phenotypes for human adult
liver stem cells and hepatoma cells. AACR Mtg., Orlando, Fl., March 27-31, 2004.
281. Y. Nakamura, N. Yoshikawa, K. Sato, K. Ohtsuki, C. Chang, B.L.Upham, and J.E.
Trosko, “Purification of the bioactive ingredient in psyllium that up-regulates gap
56
282.
283.
284.
285.
286.
287.
288.
289.
290.
291.
292.
293.
junctional communication in ras-transfected rat epithelial cells. Soc. Toxicology Mtg.,
Orlando, Fl., March 21-25, 2004.
B.L. Upham, J.P. Scott, J.M., Carbone, L. Lee, A.M. Rummel, and J.E. Trosko, “
Epigenetic mechanisms of organic tumor promoters and the anticarcinogenic role of
resveratrol.” Soc. Toxicology Mtg. Orlando, Fl., March 21-25, 2004.
J.E. Trosko, M.H. Tai, C.CX. Chang, and B.L. Upham, “Human adult stem cell markers:
Lack of gap junctional communication and Oct-4 expression as “hallmarks” in the
cause, prevention and treatment of cancers”. 7th Internatl. Symposium on Preventive
Oncology and Intervention Strategies. Nice, France, February 7-10, 2004.
J.E. Trosko, C.C. Chang, B. L. Upham and Mei-Hui Tai, “Low dose modulation of intracellular signals leading to intercellular modulation of homeostasis: Ignored concepts”.
Internatl. Workshop on Radiation Health Effects at low Doses or Low Dose Rates”.
Neuherberg, Germany, February 16-18, 2004.
J.E. Trosko, M.H. Tai, C.C. Chang, L.K. Olson, T.M. Lin and B.V. Madhukar, “Expression
of Oct-4 and lack of gap junctional intercellular communication as “hallmarkers” for
adult human stem cells and cancer cells”. 95th AACR meeting, Orlando, Fl., March 2731, 2004.
C.C. Chang, J.L. Tsai, K.K. uo, K.H.Wang, A.P.Kao, M.H. Tai and J.E. Trosko,
“Expression of Oct-4, alpha fetoprotein, and vimentin, and lack of gap junctional
intercellular communication as common phenotypes for adult human liver stem cells
and hepatoma cells”. 95th AACR meeting, Orlando, Fl., March 27-31, 2004.
B.L. Upham, P.K. Tithof, and J.E. Trosko, “The role of phosphatidylcholine PLC in the
inhibition of gap junctional communication, activation of MAPK, and the release of
arachidonic acid by specific isomers of methylated anthracenes”. 2004 World congress
on In Vitro Biology, In Vitro 40: 35-A, 2004.
M.H. Tai, D.N. Reed, and J.E. Trosko, “Cigarette smoke components inhibited gap
junctional intercellular communication and cell differentiation in human pancreatic
ductal epithelial cells”. IHPBA world Congress, June 2-6, 2004, Washington, D.C., HPB
6: 25, 2004.
J.E. Trosko and B.L. Upham, “Crioses in the chemical genotoxicity paradigm: Stem
cells, cell-cell communication and systems biology as ignored concepts”. 10th
International Congress of Toxicology, Tampere, Finland, July 11-15, 2004.
J.E., Trosko, “Use of human adult stem cells to screen for genotoxic/epigenetic toxins
and toxicants”. 5th Princess Chulabhorn International Science Congress, “Evolving
Genetics and Its Global Impact”. Bangkok, Thailand, Aug. 16-20, 2004.
J.E. Trosko, “Role of human adult stem cells and cell-cell communication in the cause,
prevention and treatment of cancer”, Oriental Medicine and Life Sciences”. Seoul,
Korea, August, 28, 2004.
J.E. Trosko, “The role of stem cells and gap junctions as targets for cancer
chemoprevention and chemotherapy”. 1st Annual Conference on Organization for
Oncology sand Translational Research (OOTR), Shangri-La Island, Hong Kong, October
15-16, 2004.
J.E. Trosko, “The role of stem cells and gap junctional communication in
carcinogenesis”. 1St Satellite Conference of the OORT Institution, Sun Yat Sen
Memorial Hosiptal, Guangzhou, China, Oct. 17, 2004.
57
294. B. L. Upham and J.E. Trosko, “A new paradigm of oxidative stress in biological
organisms”. Nagasaki University, March, 2005.
295. B.L. Upham and J.E. Trosko, “Epigenetic effects of oxidative stress”. Soc. Toxicol.
Mtg., New Orleans, March 6-10, 2005.
296. CC. Chang, M. Saitoh, M.-H. Tai, K.H. Wang and J.E. Trosko, “Human breast epithelial
stem cells as target cells for carcinogenesis. Internatl. Conference on Stem Cells:
Research and Therapeutics”. San Diego, Ca., April 11-12, 2005.
297. M. Neupane, C.C. Chang, J.E. Trosko, M. Kiupel, V. Yusbasyan-Gurkan, “ Isolation and
characterization of canine Adipose-derived mesenchymal stem cells”. Internatl.
Conference on Stem Cells: Research and Therapeutics”. San Diego, Ca, April 11-12,
2005.
298. M. Neupane, C.C. Chang, J.E. Trosko, M. Kkiupel, V. Yusbasiyan-Gukan, “The isolation
and characterization of canine adipose-derived mesenchymal stem cells”. 4th Annual
Research Day, Pediatrics/Human Development, Kellogg Center, MSU, May 6, 2005.
299. M. Guzvic, J. Scott, J.M. Carbone, C.Coe, L.L. Li, A.M. Rummel, J.E. Trosko, and B.L.
Upham, “Resveratrol reversed the effect of tumor promoting organic peroxides on gap
junctional intercellular communication and MAPK”. 4th Annual Research Day, Pediatrics
/Human Development, Kellogg Center, MSU, May 6, 2005.
300. M. Machala, K. Pencikova, L. Svihalkova-Sindlerova, L. Umanova, J. Neca, Z. Andrysik,
L. Blaha, A. Kozubik, B. Upham, J. Trosko, J. Vondracek. “Early effects of lipophilic
xenophilic xenobiotics on rat liver epithelial oval-like cells are occurring in parallel with
the inhibition of GJIC”. Gap Junction Conference, Whistler, Canada, August 13-18,
2005.
301. H Yoo, PD Jones, PW Bradley, M Guzvic, BL Upham, JE Trosko, JL Newsted and JP
Giesy. “Separation and characterization of structural isomers of perfluorinated
compounds”. Flouros Meeting, Toronto, 2005.
302. J.E. Trosko, “Adult stem cell theory of the multi-step, mult-mechanism model of
carcinogenesis: Role of inflammation on the promotion of initiated cells. Environ.
Mutagen
Society Mtg, San Francisco, September 4-8, 2005.
303. Neupane, M., Chang, C.C., Trosko, J.E., Kiupel, M., Yuzbasiyan-Gurkan, V. “Isolation
and characterization of canine adipose derived mesenchymal stem cells.” Phi Zeta
Research Day , College Veterinary Medicine, East Lansing, Michigan , Oct. 20, 2005.
304. J.E. Trosko, “The quantitative and qualitative aspects of adult human stem cells are
responsible for the aging and cancer processes: or Why didn’t Methusala ever get
cancer?” “Aging, life and Cancer: The Challenge of the 21st Century”, Erice, Sicily,
December 17-18, 2005.
305. Y. Nakamura, C.C. Chang, T. Mori, K. Sato, K. Ohtsuki, B. L. Upham, J.E. Trosko,
“Augmentation of differentiation and gap junction function by kaempherol in partially
differentiated colon cancer cells. SOT meeting, San Diego, March 5-10, 2006.
306. Y. Nakayama, Y. Nakamura, K. Sato, C.C. Chang, B.L. Upham, and J.E.
Trosko,“Induction of differentiation by kaempherol in colon cancer cells with different
differentiation profiles”. SOT meeting, San Diego, March 5-10, 2006.
58
307.
B.L. Upham, J.E. Trosko, and L. Blaha, “Inhibition of gap junctional intercellular
communication by phospholipid metabolites and protection by the red wine antioxidant, resveratrol”. Part. 2. SOT meeting, San Diego, March 5-10, 2006.
308. L. Blaha, J.E. Trosko and B.L. Upham, “The role of phospholipases in the inhibition of
gap junction communication and the activation of MAPK by specific isomers of methyl
anthracenes. Part. 1. SOT meeting, San Diego, March 5-10, 2006.
309. B.L. Upham, L. Blaha, M. Guzvic and J,.E. Trosko, “ The role of phosphatidylcholine
PLC in the inhibition of gap junction communication, activation of MAPK, and the
release of arachhidonic acid by specific isomers of methylated anthracenes”.
Duke/NIEHS Environmental Epigenomics, Imprinting and Disease Susceptibility
conference, November 1-3, 2005, Research Triangle Park, N.C.
310. H. Yoo, P.D.Jones, P.W. Bradley, M. Guzvic,B.L. Upham, J.E. Trosko, J.L. Newsted, and
J. Giesy, “Separation and characterization of structural isomers of perfluorinated
compounds
and their epigenetic toxicity”. 26th SETAC Meeting, November 14-17, 2005, Baltimore,
MD.
311. J.D. Webster, V. Yuzbasiyan-Gurkan, C.C. Chang, J.E. Trosko, and M. Kiupel, “Oct-4
expression in canine neoplasms: A potential role for embryonic genes in cancer
progression”. Amer. College Veterinary Pathologists -56th Annual Mtg, Boston,
December 3-6, 2005
312. M. Neupane, C.C. Chang, J.E. Trosko, M. Kiupel, V. Yuzbasiyan-Gurkan. “Isolation and
characterization of canine adipose-derived mesenchymal stem cells (CAD-MSCS)”. Amer.
College Veterinary Pathologists- 56th Annual Mtg, Boston, December 3-6, 2005.
313. M.H. Tai, D.N. Reed, C.C. Chang, K. D. Linning, L. K Olson, J.E. Trosko,
“ Characterization of adult human pancreatic cells possess endocrine differentiation
potential. Amer. Hepato- Pancreato-Bilary Association, March 9-12, 2006, Miami Beach,
Fl.
314. J.E. Trosko, “Modulation of the Oct-4 gene and cell-cell communication of adult human
cancer stem cells”. International symposium” Vision 2006 Bio-Korea. Seoul National
University, Seoul, Korea, Feb. 28th, 2006.
315. J.E. Trosko, “The role of adult human stem cells as targets for carcinogenesis: Oct-4 as
A marker for ‘ Oncogeny as partially blocked ontogeny’ theory of carcinogenesis”. , 2nd
Stem cell Research & Therapeutics Conference”, March 3, 2006, San Francisco.
316. J.E. Trosko, “The Use and Application of Human adult Stem Cells in Toxicology”.
BTS/UKEM Symposium, March 19-22, 2006, Birmingham, England.
317. J.E. Trosko, “Oct-4 gene expression and lack of cell-cell communication as ‘Hallmarks’ of
cancer”: Evidence for the stem cell theory of cancer”. University of Surrey, Surrey,
England, March 24, 2006.
318. J.E. Trosko, “ From adult stem cells to cancer stem cells: Oct-4 gene, cell-cell
communication and hormones during tumor promotion”. Estrogens and Human
Diseases”. Erice, Sicily, May 15-21, 2006.
319. J.E. Trosko, “ Oct-4 gene expression and lack of cell communication as ‘ hallmarks’ of
adult human stem, cells: Evidence for the stem cell theory of cancer”. Cancer Research
–UK, March 23, 2006, London, England.
320. J.E. Trosko, “Crises in the chemical genoticity paradigm: Stem cells, cell-cell
59
communication and systems biology as ignored concepts. Euro EMS Congress, July 2-6,
2006, Prague, Czech Republic.
321. J.E. Trosko, “ Concepts needed to understanding potential health effects of chronic low
level radiation exposures: Role of adult stem cells and modulated cell-cell
communication”, The2nd Nagaski Symposium of international consortium for Medical
Care of Hibakusha and Radiation Life Science. Nagasaki University, Nagasaki, July 23July 30, 2006.
322. B.L. Upham, D.A. Whitten, C. G. Wilkerson, J.E. Trosko, and L. Blaha, “Identification of
early upstream events in the inhibition of gap junctional intercellular communication and
activation of MAPK by specific isomers of methylated anthracenes”. Gordon Conference,
New Hampshire, July 24- 27, 2006.
323. J. E. Trosko, “ Status and Perspectives of stem cell research”. 50th Anniversity of
Korean Society of Veterinary Science, Chungmu, Korea, Sept. 28th, 2006.
324. J.E. Trosko, “Oxidative stress in the modulation of Oct-4 expression and cell-cell
communication in stem cell biology and during carcinogenesis”. Internatl. Symposium
Redox-sensitive transcription factors and their regulations as potential therapeutic
targets”. Seoul Natl. University, Seoul, Korea, Oct. 21, 2006.
325. J. E. Trosko, “ New strategies for dietary chemoprevention & chemotherapy for
environmentally-induced cancers: Modulation of Oct-4 gene and cell-cell communication
of adult human ‘Cancer stem’ cells”. 2nd Internatl. Conference on Toxicogenomics, Inha
University, Seoul, Korea, Nov. 6th, 2006.
326. M. Machala, Z. Andrysik, P. Polaskova, K. Pencikova, P. Krcmar, J.E. Trosko, J.
Vondracek, “ Deregulation of GJIC by 2,3,7,8-tetrachlorodibenzo-p-dioxin and nondioxin-like 2,2’,4,4”, 5,5”-hexachlorobiphenyl in rat liver epithelial WB-F344 cells”. Gap
Junction Symposium, Tokyo, Japan, Nov. 22, 2006.
327. J.Trosko,“From characterizing epigenetic toxicants, chemo-preventive/chemotherapeutic
agents to stem cells and to mechanisms of cancer and multiple chronic human diseases:
Gap junctions as a biological Rosetta Stone”. Gap Junction Meeting, Tokyo, Japan, Nov.
22, 2006.
328. Y. Nakamura. Y. Nakamura. E. Park, K. Sato, B.L. Upham, C.C. Chang and J.E. Trosko,
“Development of an assay system for simple and easy determination of cell
differentiation in well-differentiated human colon cells”. SOT meeting, Charlotte, N.C.,
March 25-29, 2007.
329. B.L. Upham, D.A. Whitten, C.G. Wilkerson, J.E. Trosko, “ Novel proteomic approach to
mapping signaling pathways induced by specific isomers of nmethylated anthracenes”.
SOT meetings, Charlotte, N.C., March 25-29, 2007.
60
330. J.E. Trosko, “From characterizing epigenetic toxicants, chemopreventive,
chemotherapeutic agents to stem cells & to mechanisms of cancer and multiple chronic
human diseases: Gap junction as a ‘Biological Rosetta Stone’”. Workshop: The role of
gap junctional intercellular communication in carcinogenesis by Industrial and
Environmental Chemicals. Foggia, Italy, March 27 & 218th, 2007.
331. J.E. Trosko, “ Environmental and dietary chemical-induced
health effects via epigenetic modulation of the quantity and quality of adult human
stem cells and cell-cell communication” The 6TH Princess Chulabhorn International
Sciencve Congress: The Interface of Chemistry and Biology in the “omics” Era”,
Bangkok, Thailand, Nov. 25-29, 2007.
332. E Cardenas, J.R. Cole, A.S. Kulam-Syed-Mohideen, Q. Wang, B. Chai, B.Upham,
S. Hashsham, J. Trosko, and N.E. Kaminski.” The MSU SBRP Molecular Biology
Tools Repository.” NIEHS SBRP Superfund Symposium, Research Triangle Park,
N.C., November, 2007.
333. J.E. Trosko, “The role of diet and environmental chemicals on the quality and
quantity of adult stem cells. At the Il Manifesto della Lunga Vita: Come La
Medicina Anabiotic combiera la Nostra esistenza”, Taormina, Sicily, Dec. 6-7, 2007.
334. S. Schwitalla, J. Seidel, S. Keil, J.E. Trosko, C.C. Chang, S. Meyer-Staeckling,
B.H.,and, B. Niggemann, K. Zaenker, T. Dittmar, “ Breast stem cell spontaneously
fuse with breast cancer cells: Impacts on cancer cell formation?” AACR meeting,
03/28-04/01, 2008.
335. Y. Nakamura, Y. Nakayama, A. Tanaka, T. Matsuo, S. Okamoto, B. L. Upham, C-C.
Chang, J. E. Trosko, E. Y. Park, K. Sato,“3-Methylthio-propionic acid ethyl ester
(MTPE), from Katsura-uri (Japanese pickling melon, Cucumis melo var. conomon),
enhanced differentiation in partially-differentiated human colon cancer cells”. SOT
meeting, Seattle, Wash, March.16-20 , 2008.
336. Y. Hirabayashi, B. Yoon, I. Tsuboi, Y. Kodama, J. Kanno, J. E. Trosko, and T. Inoue,
“ Role of Cx 32 in steady state hematopoiesis and leukemiogenesis: Study in the Cx32
knockout mice”. SOT meeting, Seattle, Wash., March 16-20, 2008.
337. B.L. Upham, P. Babica, J. Park, I. Sovadininova, J.E. Trosko, and C.C. Chang, “The
effects of cyclic aromatic hydrocarbons on gap junction function in an adult human
stem cell line. SOT meeting, Seattle, Wash, March 16-20 2008.
338. V. MICELI, L. COCCIADIFERRO, K-S KANG, L POLITO, J. E. TROSKO, G. CARRUBA,
“PROFILING CANCER STEM CELLS IN ANDROGEN RESPONSIVE AND REFRACTORY
HUMAN PROSTATE TUMOR CELL LINES. , STEROID ENZYME AND CANCER,
ETTORE MAJORANA CENTER FOR SCIENTIFIC CULTURE, ERICE, SICILY MAY 3-8th,
2008.
61
339. Trosko, J.E. “Pre- and Post-Natal Exposures to Epigenetic Toxicants and Modulation of
Risk to
Chronic Diseases”. FISV meeting, Riva del Garda, Italy, Sept. 24-27, 2008.
340. Trosko, J.E. “ State of the Art on Stem Cell Technology”, Euro Societies of Toxicology,
Rhodes, Greece, Oct. 5-9, 2008.
341. Trosko, J.E. “ Nutrigenomics , Diet & and DNA: The Promises and Challenges of
Nutrigenomics”. Dept. of Radiology, Mich. State University., Nov. 7th, 2008.
342. Iwai, S , Chai, B , Wang Q, McGarrell, D, Sul, W , C, James R, Hashsham, SA, and
Trosko, JE. Development and Application of Functional Gene and Pyrosequencing
Pipelines for Analyzing Phylogenetic and Functional Diversity of Contaminated
Sites. NIEHS- Superfund Basic Science Research Program, Innovative Science &
Technology for Mitagating Human, Ecological and Environmental Risks. Pacific
Grove, Calif., Dec. 7-9, 2008.
343. Upham, B.L., Babica, P., Park, J., Sovadinova, Blaha, L., Whitten, D.A., Wilkerson,
C.G., Trosko, J.E. Key roles of annexins and phospholipases in toxicant induced
regulation of cell signaling relevant to cancer. Soc. Toxicology, Baltimore, March 1519, 2009.
344. Park, J.-S., Babica, P., Trosko, J.E., Burgoon, L.D., Zacharewski, T., Upham, B.L.
Comparative gene expression analysis of 1- and 2- methylanthracene in rat liver cells.
8th Annual Research Day, Wayne State University, March 27th, 2009.
345. Kumar, E., Sovadinova, E., Babica, P., Boke, H., Wilke, A., Park, J.S., Trosko, J.E.,
Upham, B.L., The role of different signaling pathways in inhibition of gap junctional
intercellular communication. 8th Annual Research Day, Wayne State University, March
27th, 2009.
346. Babica, P., Park, J.S., Sovadinova, I., Blaha,L., Whitten, D., Wilkerson, C., Trosko, J.E.,
Upham, B. Intracellular signaling induced by 1-methylyantracene: Key roles of annexins
and phospholipaes. 8th Annual Research Day, Wayne State University, March 27th, 2009.
347. Muntenau, M.C., Veselinmov, M., Babica, P., Park, J.S., Trosko, J.E. & Upham, B.L.
Polycyclic aromatic hydrocarbons-Gap junctional communication-dependent or
independent inhibitors of apoptosis. 8th Annual Research Day, Wayne State University,
March 27th, 2009.
348. Munteanu, M.C., Veselinov, M., Babica, P., Park, J.S./, Trosko, J.E., and Upham, B.L.
Gap junctional intercellular communication-dependent polycyclic aromatic hydrocarbons
inhibit intrinsic but not extrinsic aopoptosis. 8th Annual Research Day, Wayne State
University, March 27th, 2009.
62
RESEARCH GRANT AND CONTRACT PROPOSALS
1.
2.
3.
4.
5.
6.
7.
8.
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11.
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14.
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34.
All University Grant proposals (3), summary reports (3).
American Cancer Society Proposals (1), summary reports (1).
Biomedical Sciences Proposals (3), summary reports (1).
AEC Contract Proposals (5), progress reports (5).
General Research Support Grant, 1970 (1).
NIH-NCI Career Development Award, 1972-73.
NIH-NCI Research Grant, 1972-74.
NIH-NCI Career Development Award, 1973-74.
NIH-NCI Career Development Award, 1974-75.
NIH-NCI Research Grant, 1974-76.
NIH-NCI Career Development Award, 1975-76.
National Foundation Grant, 1976-78.
NIH-NCI Career Development Award, 1976-77.
NIH-NCI Research Grant, 1977-80.
NIH-NCI Supplemental Research Grant, 1979-80.
NIH-NCI Postdoctoral Training Grant, 1979-84.
NCI Research Grant, 1980-84.
All University Grant, 1980-81.
MSU-Agriculture Experiment Station Grant, 1980-81.
EPA Grant, 1981-85.
NCI Research Grant, 1981-84.
NCI Research Grant, 1984-87.
USAF Grant, l986-l989.
NCI Research Grant, 1987-91.
Education Foundation of America, 1986-87.
R.J. Reynolds-Nabisco, 1987-88.
NIH-Shared Instrument Grant, 1988-89.
USAF Grant, 1989-92.
NIEHS Grant, 1989-93.
NCI Grant, 1992-96
USAF Grant, 1992-95
Michigan Great Lakes Protection Grant, 1993-94.
NIEHS Grant, 1993-94.
NIEHS Grant, 1995-2000.
63
35.
36.
37.
38.
39.
40.
41.
42.
Acrylonitrile Group gift, 1993-94.
NCI grant, 1996-2000
EPRI grant, 1996-1998
U.S. Air Force Office of Scientific Research, 1996-1999
U.S. Army Breast Cancer, 1996-2000
EPRI Grant, 1998-2000.
NIEHS Grant, 2000-2005.
McLaren Pancreatic Grant, 2001-2002
MEETINGS ATTENDED OR PAPERS GIVEN
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
American Society of Zoologists, 1964, paper given.
American Society for Cellular Biologists, 1964, paper given.
Radiation Research Society, 1966, paper given.
Third International Congress of Radiation Research, Cortina, Italy, 1966, paper given.
Radiation Research Society, 1967, paper given.
Symposium on the Behavior of Tissue Culture Cells, MSU, 1967.
Genetics Society, 1967, paper given.
Symposium on Replication and Recombination of Genetic Materials, Invited Discussant,
Canberra, Australia, 1967.
Radiation Research Society, 1968, paper given.
Fifth International Congress on Photobiology, 1968, paper given.
Genetics Society, Chaired Session, 1968, paper given.
Symposium on Recovery and Repair Mechanisms in Radiobiology, 1967.
Biophysics Meetings, 1969, paper given.
Radiation Research Society, 1969, paper given.
New York Academy of Science Meetings--New Dimensions in Legal and Ethical Concepts
for Human Research, 1969.
New York State General Education of Science Symposium invited speaker, College
Center of Finger Lakes, NY, May, 1969.
Genetic Society Meeting, August, 1969, paper given.
Radiation Research Society, 1970, paper given.
Environmental Mutagenesis Society Meeting, March, 1970, paper given.
1969 Annual Meeting of the Association of General and Liberal Studies; October
30-November 1, 1969, paper given.
International Symposium on Bacterial, Viral and Anti-Tumor Activities of Platinum
Compounds. Sept. 23-25, 1970. Chaired session and gave paper.
19th Radiation Research Meeting, Boston, MA, May 9-13, 1971, paper given.
5th International Symposium on Molecular Biology, Johns Hopkins University, June 3-4,
1971.
Genetics Society Meeting, August 27-30, 1972, paper given Minneapolis, MN.
4th National Congress on Medical Ethics, Washington, DC, Apr. 26-38, 1973.
International Congress of Genetics, Berkeley, CA, Aug. 20-24, 1973, paper given.
Michigan Tissue Culture Meeting, Michigan State University, E. Lansing, Oct. 26, 1973;
Chairman of session.
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29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
50.
51.
52.
53.
54.
55.
Environmental Mutagen Society, Washington, DC, Mar. 10, 1974; delivered symposium
address.
Meeting on Human Development Program, June 17-18, 1974, Ann Arbor, MI.
Meeting on DNA repair, Squaw Valley Conference on Molecular Biology, Feb. 24 - Mar. 1,
1974.
Symposium address, "The nature and nurture of carcinogenesis and aging", Michigan
Tissue Culture Society, Kalamazoo, MI, Apr. 25, 1975.
Protein and other adducts to DNA: Their significance to aging, carcinogenesis and
radiation biology, Williamsburg, VA, May 2-5, 1975.
NSF-NIH "Symposium on Science and Ethics". Washington, DC, Apr. 10- 12,1975.
"Genetics and the Law" Symposium at Boston, MA, May 19-20, 1975.
"Bioethics and Accountability in Research on the Environment". 27th Annual AIBS
Meetings, New Orleans, LA, June 3, 1976.
Colloque de Cancerogenese". Menton, France, July 4-9, 1976.
Genetics Society of America, Salt Lake City, UT, Aug. 15-18, 1976.
Argonne Symposium on "Accomplishments and Challenges for American Life Sciences",
Argonne National Laboratory, Oct. 11-13, 1976.
Michigan Branch of the Tissue Culture Association, Western Michigan University, Nov.
12, 1976.
Argonne National Laboratory, Workshop on "Carcinogenesis and mutagenesis by
energy-related hydrocarbons" at Argonne National Laboratory, Apr. 18-20, 1977.
5th Annual Scientific Meeting for the American Society of Photobiologists, May 11-13,
1977, San Juan, Puerto Rico.
Michigan Branch of the Tissue Culture Association, Univ. of Mich., May 6, 1977.
Genetics Society of America, Austin, TX, Aug. 14-17, 1977.
Workshop on "Chemical Modification of Mutagenesis", Williamsburg, VA Oct. 24-26,
1977.
2nd Annual Conference on the "Status of predictive tools in application to safety
evaluation", NCTR, Little Rock, AR, Oct. 27-29, 1977.
Michigan Branch, Tissue Culture Association, Lansing, Nov. 11, 1977.
Intensive course in Chemical Carcinogenesis (Amer. Chem. Soc. and Amer. Cancer
Society), Seattle, WA, Feb. 11-13, 1978.
1978 ICN-UCLA Symposia on Molecular and Cellular Biology, (DNA repair mechanisms),
Feb. 19-24, 1977, Keystone, CO.
Joint meeting of the Biophysical Society - American Physical Society, Washington, DC,
Mar. 27-29, 1978.
Environmental Mutagen Society, San Francisco, Mar. 9-13, 1978.
American Association of Cancer Research, Washington, DC, Apr. 5-8, 1978.
Michigan State Cooperative Extensive Service Symposium, "Chemicals in Our Lives", E.
Lansing, Oct. 24, 1978.
Gordon Conference on Aging, Santa Barbara, CA, Jan. 22-26, 1979.
International Conference on "Short-term tests for prescreening of potential carcinogens",
Genova, Italy, Feb. 6-8, 1979.
Workshop-Conference on Environmental Mutagenesis and Carcinogenesis, Buenos Aires,
Argentina, Mar. 18-30, 1979.
65
56.
57.
58.
59.
60.
61.
62.
63.
64.
65.
66.
67.
68.
69.
70.
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72.
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75.
76.
77.
78.
79.
80.
81.
82.
83.
84.
85.
86.
87.
88.
89.
Argonne Symposium, "Environmental Carcinogenesis: Estimation and Mitigation of
Risks", Argonne National Laboratory, Apr. 23-25, 1979.
American Association for Cancer Research, New Orleans, May 16-19, 1979.
Tissue Culture Association, Seattle, Washington, June 10-14, 1979.
NCI Conference on Aplastic Anemia/Leukemia, San Francisco, CA, June 17-19, 1979.
NIEHS Conference on Mammalian Mutagenesis, Atlanta, GA, June 25-28, 1979.
"Short-term tests for chemical carcinogens", Vancouver, BC, Aug. 20- 22,1979.
"Chemical Promoters: Amplifiers of mutated cells", Sub-committee on Environmental
Mutagenesis. DHEW-CCTRP, Bethesda, MD, Nov. 5, 1979.
American Business Cancer Research Foundation, Inc. meeting, NY, Nov. 20, 1979.
Environmental Mutagenesis Society, Nashville, TN, Mar. 16-19, 1980.
Biological mechanisms in aging, Natl. Instit. Aging, Bethesda, MD, June 23- 25, 1980.
International Symposium on "Cocarcinogenesis", Klais, Germany, October 11- 18. 1980.
Japanese Tissue Culture Society Meeting, Tokyo, Japan, Dec. 4-6, 1980.
AAAS Meeting, Toronto, Canada, Jan. 4-8, 1981.
Workshop on Exposure, Metabolism and Mechanisms of Toxicity, Task Force on
Environment, Cancer and Heart and Lung Disease. Rockville, MD, Jan. 27-30, 1981.
ICN-UCLA Symposium on Molecular and Cellular Biology, Keystone, CO, Feb. 22- Mar. 1,
1981.
Society of Toxicology, San Diego, CA, March 2-5, 1981.
NATO-Euratom Course on "DNA Repair, Cellular Sensitivity and Mutagenesis and Human
Health", MCR Cell Mutation Unit, University of Sussex, England, Sept. 9-12, 1981.
"Possible Mechanisms of Thresholds for Carcinogens and Other Toxic Substances",
Symposium, NY, Nov. 2-5, 1981.
Toxicology Forum, Washington, DC, Feb. 14-16, 1982.
International Symposium on PCB's in the Great Lakes. Michigan State University, Mar.
15-17, 1982.
WHO-SGMOSEC Workshop on "Quantitative Estimation of Risks to Human Health from
Chemicals". Rome, Italy, July 12-16, 1982.
13th International Cancer Congress, Seattle, WA, Sept. 8-16, 1982.
New York Academy of Sciences, NY, Oct. 5-7, 1982.
American College of Obstetricians, Michigan Section, E. Lansing, MI, Feb. 10, 1983.
Symposium on Mechanisms of Tumor Promotion, Budapest, Hungary, May 17-21, 1983.
International Workshop on Mutagenesis, Carcinogenesis and Teratogenesis, Shanghai,
China, May 7-June 1, 1983.
Princess Takamatsu Symposium on Mechanisms of Tumor Promotion, Tokyo, Japan,
Nov. 1983.
International Genetics Symposium, New Delhi, India, Dec. 7-18, 1983.
Ohio Cancer Center Conference, Columbus, OH, April 27-28, 1984.
AACR meeting, Toronto, Canada, May 9-12, 1984.
Symposium on Risk from Low-Level Exposure to Radiation and Chemicals: A Critical
Overview, Brookhaven Nat'l. Laboratory, Long Island, NY, May 20- 23, 1984.
Tissue Culture Association meeting, Houston, TX, May 20-23, 1984.
l5th Conference on Environmental Toxicology, Dayton, OH, Oct. 30-Nov. 1, 1984.
Soc. of Environ. Toxicol. and Chemistry, Rockville, MD, Nov. 4-7, 1984.
66
90.
91.
92.
93.
94.
95.
96.
97.
98.
99.
100.
101.
102.
103.
104.
105.
106.
107.
108.
109.
110.
111.
112.
113.
114.
115.
116.
117.
118.
119.
120.
121.
122.
123.
124.
Soc. of Toxicology, San Diego, CA, March 18-22, 1985.
Central Regional Mtg., Amer. Chem. Soc., Akron, Ohio, June 5, 1985.
Mich. Regional Toxicol. Mtg., E. Lansing, MI, May 14, 1985.
Regional American Chem. Society Mtg., Akron, OH, June 5, 1985.
4th International Conference on Environmental Mutagens, Stockholm, Sweden, June
20-29, 1985.
Workshop on Toxicity, Tumor Promotion and Carcinogenesis, Aspen, CO, July 20-25,
1985.
Society of Toxicology, New Orleans, 1986.
Environmental Mutagen Society, 1986.
NCI-Organ System Symposium, Rockville, MD, 1986.
DNA Amplification in Tumor Initiation and Promotion, Symposium, Heidelberg, Germany,
October, 24-26, 1986.
NCI-Organ Systems Meeting, Washington, DC, December, 1986.
EPA Workshop on Tumor Promoters, Bethesda, MD, February 4-6, 1987.
Charles Heidelberg Memorial - Tumor Promotion, Honolulu, Hawaii, February, 1988.
Intern. Risk Assessment Mtg., Oak Ridge, TN, March 20-23, 1988.
Environmental Mutagen Society Mtg., Charleston, SC, March 27-31, 1988.
Intern. Cytometry Society Mtg., Breckenridge, CO, Sept. 4-9, 1988.
Amer. College of Nutrition Mtg., New Orleans, Sept. 16, 1988.
Pancreas Cancer Working Group, Bethesda, Sept. 19-20, 1988.
Intern. Mtg. on Gap Junctional and Toxicology, E. Lansing, Sept. 28-30, 1988.
18th Conference on Toxicology, Dayton, Ohio, Nov. 1-3, 1988.
Mouse Liver Carcinogenesis Conference, Austin, Texas, Nov. 30 - Dec. 3, 1988.
Inter. Life Science Instit. Conference, Paradise Island, Jan. 15-21, 1989.
Radiation Res. Mtg., Seattle, Washington, March 22-24, 1989.
Molecular and Cell Biology of Gap Junctions Symposium, Irsee, Germany, July 18-23,
1989.
Practical In Vitro Toxicology Symposium, Nottingham, England, July 23-27, 1989.
Symposium on Molecular Cell Biology of Liver Growth and Function, Lake Placid, NY,
Aug. 13-16, 1989.
Symposium on "Eicosanoids and Bioactive Lipids in Cancer and Radiation Injury".
Detroit, MI, Oct. 11-14, 1989.
Workshop on "Mechanisms of Aging". Hiroshima, Japan, March 29-31, 1990.
AACR meeting in Washington, D.C., May 23-26, 1990.
EMS meeting, Albuquerque, New Mexico, March 25-29, 1990.
Soc. of Risk Analysis meeting, Washington, D.C., May 21-23, 1990
NIEHS meeting, "Agricultural Chemical Utilization and Human Health". Research
Triangle Park, NC, July 12-13, 1990.
International Round Table Meeting by Foundation Rhone-Poulenc Sante in Les
Pensieres, France, October 16-19, 1990.
Japanese Radiation Research Society Meeting in Sendai, Japan, October 24-26, 1990.
International Symposium on "Radiation Carcinogenesis in the Whole Body System”.
Tokyo, December 5-6, 1990.
67
125. Workship on "Oncogenic Mechanisms in Radiation Induced Cancer" by Radiation
Research Society, Ft. Collin, Colorado, January 16-19, 1991.
126. Workshop on "The Future of Human Radiation Research," RERF/DOE Meeting, Elmau,
Germany, March 3-8, 1991.
127. Workshop on "Biological Effects of Low Dose Radiations”. Yokohoma City Univrsity (Dr.
M. Watanabae), March 12, 1991.
128. International Symposium on "Roles of Flow and Interactive Laser Cytometries in the Life
Science and Cancer Research”. Wankwang University, Iri, Korea, May 10, 1991.
129. Korean Society of Molecular Biology, Iri, Korea, May 11, 1991.
130. International Symposium Environmental Mutagenesis and Carcinogenesis, Shanghai,
China, May 27-29, 1991.
131. World Congress in Medical Physics and Biomedical Engineering, Kyoto, Japan, July 7-12,
1991.
132. Conference on Biological Effects of Low Level Exposures to Chemicals and Radiation,
BELLE Conf., Washington, D.C., April 26-27, 1993.
133. Workshop on "Comparative Pathobiology of Environmental Disasters”. Washington,
D.C., April 17-21, 1993.
134. International Symposium on Gap Junctions, Hiroshima, Japan, August 24-27, 1993.
135. Society of Toxicology meeting, Dallas, Texas, March 13-17, 1994.
136. Workshop on "Priorities in Health Effects Research-Ionizing Radiation”. NIEHS
Conference, Research Triangle Park, NC, March 21-22, 1994.
137. Workshop on "Development and Applications of Biomarkers," DOE Conference, Santa
Fe, NM, April 26-29, 1994.
138. National Surgical Adjuvant Breast and Bowel Project," Nashville, June 12-13, 1994.
139. International Symposium, "Medical physics and biomedical engineering", Rio de Janeiro,
Brazil, Aug. 21-26, 1994.
140. International symposium, "Biological indicators of exposure to ionizing radiation" at
Schloss Reisenberg, Germany, Sept. 26-30, 1994.
141. International symposium, "Physical insult from and biological responses to low level
ionizing radiation" at Brookhaven Natl. Lab., Nov. 3-4, 1994.
142. Symposium on "Signal transduction processes in the regulation of gene expression,
cellular function and toxicity", Wayne State Univ., Nov. 11, 1994.
143. Workshop on "Mechanism-based toxicology in cancer risk assessment: Implications for
research, regulation and legislation". Natl. Toxicol. Program, Chapel Hill, N.C., Jan. 1113, 1995.
144. Society of Toxicology Mtg., Baltimore, March 5-9, 1995.
145. EPRI-Workshop on "Electromagnetic Fields", Santa Barbara, California, March 19-22,
1995.
146. Symposium on Molecular Biology and Radiation Protection, Ottawa, Canada, April 25,
1995.
147. Michigan Branch of Soc. of Toxicology, Ann Arbor, Michigan, May 19, 1995.
148. US Air Force Office of Scientific Research Program Review, Fairborn, Ohio, May 30June 1, 1995.
149. 17th Annual Bioelectromagnetic Society Meeting, Boston, Mass., June 18-22, 1995.
150. AACR, 1996.
68
151. Society of Toxicology, 1996.
152. World Congress on In Vitro Biology, San Francisco, CA, June 22-27, 1996.
153. 10th International Conference Diagnostic Quantitative Pathology, Sendai, Japan, Nov.
1996.
154. AFOSR Toxicology Program Rev., Fairborn, OH, Dec. 12-13, 1996.
155. Society of Toxicology, Cincinnati, Ohio, March 7-13, 1997.
156. AARC Meeting, San Diego, CA, April 12-16, 1997.
157. NIEHS-Superfund Program Meeting, Res. Triangle Park, NC, Feb. 24-27, 1997.
158. NIEHS-EMF Science Review Symposium, Res. Triangle Park, NC, March 24-27, 1997.
159. 1997 International Gap Junction Conference, Key Largo, Florida, July 12-17, 1997.
160. Symposium on “Mobile Phones: Is there a health risk?” Brussels, Belgium, Sept. 16-17,
1997.
161. International Conference on “Health effects of low level exposure: Scientific
developments and perspectives for risk assessments”, Utrecht, Netherlands, Oct. 19-21,
1997.
162. Symposium on “IL Carcinoma della Prostata”. Bologna, Italy, Nov. 26-29, 1997.
163. Society of Toxicology, Seattle, Washington, March 1-5, 1998.
164. Experimental Biology ’98 Meeting, San Francisco, CA, April 18-22, 1998.
165. International Conference on Diet and Prevention of Cancer, Tampere, Finland, May 28June 2, 1999.
166. 21st Annual Meeting of The Bioelectromagnetics Society (BEMS), Long Beach, CA, June
20-24, 1999.
167. 11th International Congress of Radiation Research, Dublin, Ireland, July 20-22, 1999.
168. 2nd Satellite In Vitro Human Cell Transformation Meeting, Cork, Ireland, July 24, 1999.
169. 1999 International Gap Junction Conference, Gwatt, Switzerland, August 28-Sept. 2,
1999.
170. Epigenetic Toxicant-Induced Signal Transduction and Altered Cell-Cell Communication
Symposium, University of Michigan, October 17-20, 1999.
171. The Fourth Princess Chulabhorn International Science Congress, Chemicals in the 21st
Century, Bangkok, Thailand, November 28-December 2, 1999.
172. International Symposium on Environmental Endocrine Disruptors ’99, Kobe, Japan,
Dec. 9-11, 1999.
173. International Congress on Food Factors, Kyoto, Japan, Dec. 13-17, 1999.
174. Society of Toxicology meeting, Philadelphia, Pennsylvania, March 19-23, 2000.
175. Proc. Am. Assoc. Cancer Res. AACR Annual Meeting, San Francisco, CA, April 1-5,
2000.
176. International Conference on Arctic Development, Pollution and Biomarkers of Human
Health, Anchorage, Alaska, May 1-3, 2000.
177. Department of Defense Breast Cancer Research Program Meeting: Era of Hope,
Atlanta, Georgia, June 8-12, 2000.
178. IEEE AP-S International Symposium and URSI Radio Science Meeting, Salt Lake City,
Utah, July 16-21, 2000.
179. The 2nd Congress of the Asian Society of Toxicology ASIATOX II, Cheju Island, Korea,
August 23-25, 2000.
69
180. International conference Antimutagenesis & Anti-carcinogenesis, Grand Rapids,
Michigan, Sept. 23-27, 2000.
181. SOT meeting, San Francisco, California, March 25-29, 2001.
182. Michigan Society for Clinical Laboratory Science, April 18, 2001.
183. The Stem Cell Differentiation, Genetic Reprogramming and Programmed Cell Death”,
Santorini , Greece, Sept. 2-7th, 2001.
184. The European Philosophical Society, Mali Losinj, Croatia,
185. The International Environmental Mutagen society Meeting, Shizuoka, Japan, Oct.2027th, 2001.
186. The International meeting on Low Level Radiation Effects, Kagoshima, Japan, Nov. 11th,
2001.
187. The Okinawa International Conference on Longevity, Nago, Okinawa, Nov. 12th-13th,
2001.
188. The Internatl. Conference on Balkan Endemic Nephropathy, Michigan State University,
Sept. 30- Oct. 3, 2002.
189. Nagasaki Symposium of International Consortium for Medical Care of Hibasusha and
Radiation Life Sciences”. Nagasaki, Japan, Feb. 21-22, 2003.
190. First Nagasaki Symposium of International Consortium for Medical Care of Hibasusha
and
Radiation Life Sciences”. Nagasaki, Japan, Feb. 21-22, 2003.
191. Society of Toxicology Meetings in Salt Lake City,: “ Overview of the interplay between
genetics and Epigenetic Abnormalities in Cancer”, March. 9, 2003.
192. International Symposium to Honor Dr. Robert Hollingworth, Amer. Chemical Soc. New
Orleans, March 24, 2003.
193. “Stem cells, cell-cell communication and epigenetic toxicants: Risk assessment
implications”. 2003 Congress on In Vitro Biology, Portland, Oregon, June 2, 2003.
194.
ICMAA-VII, 8Th International conference on mechanisms of anti-mutagenesis and
anticarcinogenesis. Pisa, Italy, Oct. 4-8, 2003.
195. International Course on “ Signal Transduction and communication in cancer cells”.
Erice, Sicily, Oct. 24-31, 2003.
196. Adv. Workshop on “ Radiation-induced multi-organ involvement and failure: A
challenge for pathogenic, diagnostic and therapeutic approaches and research”.
Schloss Reisenburg, Ulm, Germany. Nov. 12-15, 2003.
197. Adv. Workshop on “ Radiation-induced multi-organ involvement and failure: A
challenge for pathogenic, diagnostic and therapeutic approaches and research”.
Schloss Reisenburg, Ulm, Germany. Nov. 12-15, 2003.
198. 7th International Symposium on Predictive Oncology and Intervention Strategies” Nice,
France. February 7-11, 2004.
199. 10th International Congress of Toxicology, Tampere, Finland, July 11-15, 2004.
200. 5th Princess Chulabhorn International Science Congress, “ Evolving Genetics and Its
Global Impact”. Bangkok, Thailand, Aug. 16-20th, 2004.
201. Oriental Medicine and Life Sciences”. Seoul, Korea, August 28th, 2004.
202. 1st Annual Conference on Organization for Oncology sand Translational Research (
OOTR), Shangri-La Island, Hong Kong, Oct. 15-16, 2004.
70
203.
204.
205.
206.
207.
208.
209.
210.
211.
212.
213.
214.
215.
216.
217.
218.
219.
1St Satellite Conference of the OORT Institution, Sun Yat Sen Memorial Hospital,
Guangzhou, China, Oct. 17th, 2004.
Environmental Mutagen Society Meeting, San Francisco, Sept. 4-6, 2005.
Current Trends to streamline the safety assessment of pharmaceuticals”, Paris, France,
Nov. 17-18, 2005.
“ Aging, life, and Cancer”. Erice, Sicily, Dec. 15-19th, 2005.
Internatl. Symposium on “ Vision 2006, BIO-KOREA, Seoul Natl. University, Seoul, Korea,
Feb. 27-28, 2006.
2nd Annual Stem Cell Research and Therapeutics Symposium, Gtcbio , San Francisco,
Ca., Marh 2-3, 2006.
British Toxicology society/ UKEMS Spring Congress, Warrick, England, March 19-22,
2006.
Internatl. Symposium on “ Estrogens and Human Diseases”. Erice, Sicily, May. 15-21,
2006.
European Commmission , Joint Research Center, “ Standardization of cell culture
procedures for growth and differentiation of human ES cells lines for toxicity testing,
Ispra, Itlay, Jan. 25-26, 2007
Internatl. Association of Lions Clubs, “ Donne e Preventionzione Oncologica”. Palermo,
Sicily, March 24, 2007.
The role of gap junctional intercellular communication in carcinogenesis by industrial and
environmental chemicals”. University of Foggia, Foggia, Italy, March 27-28, 2007.
North American Congress of Clinical Toxicology, Toronto, Canada, Sept. 13, 2008.
Italian FISV Congress, Riva del Garda, Itlay. Sept. 22-26, 2008.
European Environmental Mutagen Society, Rhodes, Greece, Oct. 2-5, 2008.
Nutrigenomics , Diet and DNA, Radiology Dept., Michigan State University, Nov. 7, 2008.
Michigan Socierty of Toxicology, Ann Arbor, Michigan, Nov.14 , 2008
Pharmaceutics in the Environment: Current Trends and research Priorities, Michigan
State University, Nov. 21, 2008.
SEMINARS, INVITED LECTURER, ETC.
1.
2.
3.
4.
5.
6.
Biophysics Department, 1966, "Relationship between UV-induced molecular damage and
biological manifestations.
Seminar--Genetics Group at Cornell University, Dec. 12-15, 1967.
a.
Nature and role of UV-induced molecular damage in higher organisms.
b.
Studies on DNase and DNA polymerase activities in Drosophila development.
MSU/AEC Plant Research Laboratory Seminar, "Effects of UV-light on plants". Jan. 11,
1968.
Seminar--Genetics Group, "Molecular basis for UV-induced biological damages". Jan. 19,
1968.
Seminar--Natural Science Dept., "Molecular basis for UV-induced biological damages".
Jan. 26, 1968.
Seminar--Zoology Dept., "Molecular basis for UV-induced mutations and chromosome
breaks in human cells". Apr. 5, 1968.
71
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
Annual Report--MSU/AEC Plant Research Laboratory, Mar. 8, 1968, "Response of
tobacco and Haplopappus cells to ultraviolet irradiation after post- treatment with PR
light".
Biophysics lectures: two 2-hour lectures.
a.
Radiation Damage to DNA, Feb. 21, 1969.
b.
Radiation Damage to Cells, Feb. 28, 1969.
Biophysics lecture, one hour, "Radiation damage to higher organisms", May 5, 1969.
"Humanistic Science: Meeting the needs of the future", Invited speaker, New York State
General Education of Science Symposium, Finger Lakes, NY, May 7, 1967.
Kappa Kappa Gamma Honors Awards Speaker: "C.P. Snow's two cultures: Ethical
Responsibilities of the scientists and laymen", May, 1968.
Physical science judge in the 21st Annual Talent Exhibit and Science Fair, Mar. 30, 1968.
Triangle Fraternity Honors Awards speaker, "T-minus X and Counting", Apr. 13, 1969.
Agriculture Engineer Honorary Fraternity Symposium speaker, "Fallout-1969, May 22,
1969.
Upward Bound science lecturer (2-2 hr), "Spirit of Science", June, 1968.
Discussant on panel, "Science as Liberal Study", 1969 Annual Meeting of the
Association of General and Liberal Studies at Colgate University, Hamilton, NY, Oct.
30-Nov. 1, 1969.
Beta Beta Beta, Honorary Biology Fraternity, "Ethical Implications of Genetic
Engineering", May 27, 1968.
Guest lecturer in Human Genetics (844), May 28, 1969.
Seminar at Macalester College, St. Paul, MN, May 13-14, 1969
a.
"Possible molecular basis for UV-induced mutations and cancer in humans.
b.
"The dilemma in considering the ethical responsibility of scientists in our
technological age".
Lyman Briggs lecture, "Place of human values in technological engineering of social
problems", Nov. 21, 1969.
Lecturer in "Great Issues" course: "If ethical principles deny our right to do evil in order
that good may come, are we justified in doing good when the foreseeable consequences
are evil in a technological society?", Dec. 1, 1969.
Provost-Faculty Seminar, "The effect of science and technology on human values", Nov.
18, 1969.
Lecturer to "Adventure in World Understanding", an International Student Meeting, Dec.
23, 1969, Michigan State University. 'Implications of the World Population Situation".
Lyman Briggs College, "Genetic Engineering: Ethics and Options". Apr. 3, 1970.
Education Reform Committee, "Innovative teaching: What are the primary elements?",
Apr. 13, 1970.
"Winds of Change", seminar speaker. "Biochemical warfare in the context of the
balance of nature:. Apr. 18, 1970.
Environmental "Teach-In", Hazards in the environment: When is enough, enough?",
Apr. 22, 1970.
Sparrow Hospital Seminar, "Molecular basis for teratological effects". May 26, 1970.
Lansing Gabriels High School, "What role will genetics play in the future of man?", May
25, 1970.
72
30.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
50.
51.
52.
53.
Biochemistry seminar, "Sunlight, Man and Cancer", May 28, 1970.
Oak Ridge Biology Division seminar speaker, "Science as a relevant liberal art", Aug. 10,
1970.
Biophysics lecturer, "Molecular basis for radiation damage", Aug. 17-26, 1970 (5
lectures).
Guest lecturer to the First Christian Church of East Lansing. Gave talk entitled "Can
there be social control of science and technology within our traditional values system?",
Aug. 25, 1970.
Invited lecturer in "Man: The endangered species" course. "Creation of new values for
a technological future". Sept. 30, 1970.
Invited lecturer to the Zero Population Growth Group on Oct. 21, 1970. "Creation of
values for an over populated and technological future".
Guest lecturer to the JMC Geography 254A class (Geography and Ecology Action).
"Values to maintain ecological balance". Nov. 3, 1970.
Panelist on "human Values in a Technological Society", Okemos PTA, Jan., 1971.
Panelist on "Discussion on anti-evolution book: Biology; A search for order in
complexity", for WKAR program, Colloquy, Jan. 24, 1971.
Panelist on "Future Trends in biophysical research:. Biophysics Dept., Feb. 22, 1971.
Biochemistry 401 guest lecturer. "Sunburn, Cancer and Nucleic Acids, Feb. 22, 1971.
Delta Phi Epsilon (International Fraternity) guest speaker. "Value implications of
technological developments of underdeveloped nature", Mar. 4, 1971.
Speaker at Lansing Catholic Central High School:
"Environmental and genetic
engineering of man", Mar. 11, 1971.
Panelist on "Human values for the future", Okemos TPA, Mar. 16, 1971.
"In what way can science aid our understanding in the value of the sanctity of life",
Charlotte High School, Mar. 30, 1971.
"Radiation and human development: Molecular lesions, mutations and malformations",
speaker at 10th Annual Michigan Conference on Maternal and Perinatal Health, Lansing,
MI, Apr. 15, 1971.
"Human values for an overpopulated technological future". Earth Day speaker at
Charlotte High School, Apr. 22, 1971.
Speaker for Alpha Sigma fraternity. "Radiation Pollution", Apr. 28, 1971.
Guest speaker in Medicine and Society course. "Eugenic, Euthenics and Euphenics",
May 4, 1971.
Guest speaker in JMC - Senior seminar course (M. Powell), "Living in a future
characterized by unlimited knowledge or a Golden Age", May 6, 1971.
Four 1-hour lectures to Biophysics 402. "Molecular basis for radiation damage and
repair in higher organisms", May, 1971.
Guest speaker in IDC 201 course: "Man, the endangered species". Lectured on
"Radiation and chemical synergisms", and "Change, adaptations and values", May 24
and 26, 1971.
Guest speaker in JMC Sociology course 250A. "The history of the future". May 27,
1971.
Guest speaker at "college Week for Women", Michigan State University, June 15-18.
1971. "Human values in a changing world: A look at values and their consequences".
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74.
75.
Lecturer to "Ecology of Man" seminar series. "Human values for a technological future".
Oct. 16, 1971 for Dr. B. Sandefur.
Lecture for Medicine and Society course, "Ethical implication of genetic control
(eugenics)". Oct. 19, 1971.
Guest speaker at Flint Hurley Hospital, "A new basis for medical ethics". Nov. 3, 1971.
Guest lecturer to the Michigan State University's Great Issues course. "Ethical
implications of undergraduate education", for Dr. L. Krupka, Nov. 23, 1971.
Lecture on "General education in science for liberal arts students", Calvin College, Dec.
3, 1971.
Seminar on "New perspectives and problems in the research on the repair of DNA" to
AEC Plant Biology Research Laboratory, Jan. 10, 1972.
Lecture to Biochemistry 451 "Xeroderma pigmentosum: DNA repair enzymes". Jan. 13,
1972.
Lecture for Dr. J. Higgins' Human Genetics course: "Molecular mechanisms of
mutagenesis". Feb. 16, 1972.
Lecture, "The comparative consequences of an "A prior ethics versus a bioethic in the
future of a technological world", to Dr. G. Drum's class, Feb. 18, 1972.
Seminar to Dr. J. Kirk's class on Science and Social Issues, "Abortion: A matter of
human rights or human needs". Feb. 23, 1972.
Guest speaker for Michigan Council on Family Relations and Michigan Home Economics
Assoc., on "Basis for establishing life value". Feb. 26, 1976.
Seminar on "Photochemistry of DNA" to the Physical Chemistry Group at Michigan State
University, Mar. 7, 1972.
Debate with Rev. C. Pinnock on "Is God Necessary?", Arp. 10, 1972. Michigan State
University, public.
Four lectures for Biophysics 402 and 823 classes for Dr. A Haug. "Molecular damage
and the repair of DNA in higher organisms". Apr. 24-27, 1972.
Guest lecturer for Dr. M.J. Joseph's class on Existentialism, "A scientist critically looks at
Existentialism as a philosophy of life", May, 1972.
Whitmore Lake High School Commencement Speaker, "Malaise, Morals and Meaning",
June 4, 1972.
Guest speaker for College Week for Women, "New values to save the ecology of man",
June 14, 1972.
Seminar to Genetics Dept. at the Univ. of Wisconsin, "DNA repair mechanisms in
Drosophila and its implication to the study of mutagenesis in eukaryotes", Sept. 13,
1972.
Seventh Annual Convocation speaker of the College of Human Medicine, Michigan State
University; "Would Prometheus have qualified for Medicaid?", Sept. 20, 1972.
Seminar to McArdle Laboratory for Cancer Research, "Evidence for a caffeine-sensitive
DNA repair mechanism reponsible for mutagenesis in mammalian cells", Sept. 26, 1972.
Guest lecturer to Human Ecoloty (FE 401) course, "Human values for a technological
future", Michigan State University, Nov. 28, 1972.
Guest lecturer at the International Symposium on the "Role of Idealogies in Chaotic
Age"; God's Puppet or Skinner's Pigeon:
Are there no hopeful idealogies for
humankind?", University of Houston, Feb. 28-Mar. 1, 1973.
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92.
93.
94.
95.
96.
Seminar to Biologhy Research Center Group, Michigan State University, "Bioethics",
Sept. 24, 1973.
Biophysics seminar, Michigan State University, "Scientific concepts of human nature and
their implications to ethics". Oct. 1, 1973.
Guest lecturer to Human Ecology (FE 401), "Nature of human nature", Oct. 4,11, and
18, 1973.
Guest lecturer to Michigan State Medical School Focal Problem Group, "What can the
sciences contribute to our understanding of human nature?", Oct. 16, 1973.
Panelist at National Foundation meeting on the "Effects of drugs on human congenital
defects", Lansing, MI, Nov. 10, 1973.
Seminar to Naval Research Company, "New concepts of mutagenesis, carcinogenesis
and aging", E. Lansing, MI, Nov. 19, 1973.
Seminar to Michigan State University's Pharmacology Dept., Nov. 20, 1973.
Seminar to Michigan State University's Biochemistry Dept., "Evidence for a
caffeine-sensitive enzymatic process responsible for mammalian mutagenesis", Nov. 21,
1973.
Seminar to Wayne State Medical School, "Molecular basis for mutagenesis and
carcinogenesis in human beings", Detroit, MI, Feb. 7, 1974.
Guest lecturer to Dr. Van Tassell's Nat. Sci. course, "Philosophical basis for our ecological
and psycho-social crises", Feb. 13, 1974.
Seminar to the University of Michigan's Medical School and Genetics Dept.,
"Philosophical basis (bioethics) for moral decisions in modern medicine", Ann Arbor, MI
Mar. 29, 1974.
Symposium Address, "Role of DNA repair in mutagenesis in eukaryotic organisms",
Environmental Mutagen Society, Mar. 10, 1974, Washington, DC.
Guest lecturer, "On understanding human development", Dr. Dr. L Shiamberg's Family
and Child Study class, Michigan State University, Apr. 3, and 10, 1974.
Seminar to Upjohn Pharmaceutical Company, Kalamazoo, MI., "Molecular basis for the
genetic and environmental influences on mutagenesis and carcinogenesis in human
beings", Apr. 17, 1974.
Seminar to Upjohn Pharmaceutical Company, Kalamazoo, MI, "Molecular basis for the
genetic and environmental influences on mutagenesis and carcinogenesis in human
beings", Apr. 17, 1974.
Guest lecturer to Dr. C. Kohrman's Sociology 201 class, "Philosophical basis for the
ecological and psycho-social crises in the technological countries", Apr. 22-23, 1974.
Consultation at the Wisconsin Research and Development Center for Cognitive Learning,
May 2-3, 1974.
Guest lecturer to Evolution 801 class (Dr. H. Kitchen) "Molecular basis for evolution",
May 6 and 8, 1974.
Radio broadcast, Campus Station, "Scientific, philosophical and ethical dimension of the
potential to delay aging", May 9, 1974.
Guest lecturer to University Lutheran Church, E. Lansing, MI, "Genetics Control of
Human Development", June 2, 1974.
Consultation at the Wisconsin Research and Development Center for Cognitive Learning,
June 24 and 25, 1974.
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115.
116.
117.
118.
Radio broadcast on WKAR, "Cancer: Where are we now?", Oct. 20, 1974.
Seminar to Michigan State University Cancer Group, "The nature and nurture of cancer",
Oct. 31, 1974.
Seminar to Genetics Group at the University of Indiana on "The genetic basis for
carcinogenesis", Nov. 19, 1974.
Seminar to Methodist Hospital of Indianapolis, "On making humane human beings in a
`garbage in-garbage out' system", Nov. 20, 1974.
Guest lecturer to Human Ecology senior class (FE 401), "Human nature and the ethics of
human intervention", Dec. 3, 1974, Dr. N. Axinn's class).
Guest lecturer to Dr. Diana Marinez (2-l hr. sessions) on "The role of science in the
resolution of contemporary human problems", Nov. 28, 1974.
Channel 12-TV broadcast in Flint, MI, "A time to build" with Rev. Don Eder. Topic:
"Philosophical implications of the advances of the life sciences", Feb. 6, 1975.
Seminar to Radiology Group at Ohio State University, Apr. 18, 1975, on "The Nature of
Bioethics".
Guest speaker at Michigan Tissue Culture Assoc. Meeting, Kalamazoo, MI, Apr. 25, 1975,
"Nature and Nurture of Carcinogenesis".
Guest speaker at Biophysics Course 401, "Biophysics of Cancer and Aging", May 23, and
27, 1975.
Main speaker at Symposium on "Protein and Other Adducts to DNA: Their Significance
to Aging, Carcinogenesis and Radiation Biology", Williamsburg, VA, May 2-3, 1975.
Guest lecturer to Unitarian Universalist Church, June 22, 1975, "Cancer and Aging: Are
they the consequence of humans as `Fallen Angels' or as `Ascended Apes', in East
Lansing.
Guest lecturer to Dr. Larry Schiamberg's class (831) on "Ethics of genetic counseling",
July 2, 1975.
Lecture to Ecology and theology Course (Dr. L. Krupka) on the "Ethical framework
leading to the environmental crises", July 25, 1975.
Lecture on the "Ethics of human intervention", to Dr. Larry Schiamberg's Human
Development in the Family Course (FCS 820) on Oct. 9, 1975.
Seminar to Radiology Department at MSU on "The mechanisms of carcinogenesis and
aging", Oct. 14, 1975.
Guest lecturer to the "Great Issues" course of Dr. L. Krupka on "Philosophical implication
of cancer and aging research", Nov. 3, 1975.
Seminar to the Industrial and Environmental Health Unit at the University of Michigan,
"The Ying-Yang Theory of Cancer and Aging", Nov. 13, 1975.
Seminar to the Zoology Dept., MSU, on "Various theories of cancer and aging", Nov. 17,
1975.
Channel 12-TV broadcast in Flint, MI on "Who should pull the plug?", Nov. 20, 1975 on
Father Eder's program, "A Time to Build".
Guest lecturer to Dr. Ron Wilson's Nat. Sci. Course, on the "Philosophical implications of
cancer and aging research", Nov. 25, 1975.
Guest lecturer at the Medical Ethics Conference, at St. Lawrence Hospital, "The Ethics of
Conquer Cancer Now!", Dec. 11, 1975.
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139.
140.
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142.
Invited lecturer to the new 6-year Medical Class at Milwaukee Medical College, Jan 27,
1976, "On making humane human beings in a `garbage in- garbage out' system".
Guest lecturer at Milwaukee Children's Hospital, Jan 28, 1976, "On the ethics of
`Conquer Cancer Now'!".
Seminar on the "Ying-Yange of Cancer and Aging", to the Zoology Department Michigan
State University, Feb. 16, 1976.
"On the nature and nurture of the human brain and its implications to human learning
and learning disorders", Cornell Elementary School, Okemos, MI, Feb. 23, 1976.
"The future of cancer research as seen by one whose view is distorted by the battle",
Radiology Department, Mar 9, 1976.
"The Pontius Pilate Syndrome Cancer and Bioethics", Naval Reserve Company, Lansing,
MI, Mar. 23, 1976.
"The future of cancer research", Civitan Club, Apr. 6, 1976, Lansing, MI.
"Defective DNA repair in xeroderma pigmentosum and its variants", Society for
Investigative Dermatology, Atlantic City, Apr. 29, 1976.
"Cancer and aging: Are they due to human beings as `fallen angels' or as `ascended
apes'?", Argonne National Laboratory, May 16, 1976.
"On making humane human beings in a `garbage in-garbage out' system", Sigma Xi
lecture, University of Chicago, May 6, 1976.
"Evolution vs. creationism". Debate with Dr. Wysong, Michigan State University, Lyman
Briggs, College, May 19, 1976.
"Potential biological consequences of alternative energy sources", Union City High
Schoo, May 21, 1976.
"Biophysics and cancer and aging research", Biophysics Course 402, Michigan State
University, June 1, 1976.
"Pontius Pilate Syndrome: Cancer and Bioethics", AIBS Meetings, New Orleans, LA, June
3, 1976.
"Integrative theory of cancer", International Symposium on Carcinogenesis, Menton,
France, July 4-9, 1976.
"Genetics and cancer", Grace Methodist Church, Aug. 5, 1976, Lansing, MI
Guest lecturer for Dr. Schiamberg's Human Ecology 801 course, Oct. 5,1976.
"An integrative theory of carcinogenesis", Genetics Seminar, Michigan State University,
Oct. 6, 1976.
Guest lecturer for Dr. L. Isaacs, JMC 299 course, "The human dimensions of cancer
research", Oct. 20, 1976.
"The bioethics of genetic engineering", Wayne State University, Oct.23,1976.
"Pontius Pilate syndrome and the ecological crisis", Dept. Natural Resources, Nov. 4,
1976.
Guest lecturer for Dr. Milton Powell's JMC course, "The History of Investion:, Nov. 11,
1976.
In vitro assay to distinguish carcinogenic mutagens from carcinogenic gene modulators:,
Mich. Branch Tissue Culture Assoc., Western Michigan University, Nov. 12, 1976.
"Molecular basis for mutagenesis", Biology Division, Brookhaven Nat'l. Laboratory, Nov.
18, 1976.
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155.
156.
157.
158.
159.
160.
161.
162.
163.
164.
165.
"Recent advances in cancer research", American Cancer Society lecturer, Impression 5
Museum, Lansing, Jan. 9, 1977.
"Implications of a new cancer theory", WOOD-TV, Grand Rapids, Jan. 29,1977.
"Implications of a new cancer theory", WXYZ-TV, Detroit, Feb. 1, 1977.
"Pontius Pilate Syndrome: Cancer, Aging and Bioethics" and "An Integrative Theory of
Cancer", University of Wyoming, Feb. 3-4, 1977.
"Recent advances in cancer research", American Cancer Society lecturer at the Lion's
Club, Jackson, MI, Feb. 14, 1977.
"Is cancer due to humans as `Fallen Angles' or `Ascended Apes'?".
Human
Development seminar, Michigan State University, Feb. 16, 1977.
"Nutrition and carcinogenesis: First the `good news' then the `bad news'". Human
Nutrition and Food Science Dept., Michigan State University, Feb. 21, 1977.
"Integrative theory of carcinogenesis", Radiology Dept., Ohio State University, Feb. 24,
1977.
"Pontius Pilate Syndrome, Cancer and Bioethics", Ohio State University Feb. 25, 1977.
"Cancer and the stewardship of the body and the environment", University Lutheran
Church, E. Lansing, Feb. 27, 1977.
Guest lecturer to Dr. J. Goately's class on the "Human dimensions of science", Mar. 27,
1977.
Guest lecturer to Dr. Eisenstein's Biophysics 401 class, "The molecular basis for genetic
and environmental factors influencing cancer induction", Apr. 25, 1977.
Seminar to the Oncology Group at Harvard University, "Is cancer due to humans as
`Fallen Angels' or `Ascended Apes'?", Apr. 29, 1977.
Symposium address at the 5th Annual Meeting of the American Society for
Photobiologists and the Radiation Research Society, "The relation between mutagenesis
and carcinogenesis", May 12, 1977, San Juan, Puerto Rico.
"Recent advances in cancer research", American Cancer Society lecturer at the Kiwanis
Club, Jackson, MI, July 22, 1977.
Guest lecturer to Dr. Schiamberg's FCS 820 class, "Scientific concepts of human nature
and their implications to understanding the family", July 24,1977.
"Integrative theory of carcinogenesis", Institute of Environmental Medicine, NYU, Oct. 4,
1977.
Guest lecturer to Dr. Schiamberg's FCS 820 class, "Human nature, human intervention
and human development", Oct. 13, 1977.
"In vitro assay for tumor promoters and anti-promoters", 2nd Annual Conference on
Status of Predictive Tools in Application to Safety Evaluation", NCTR, Little Rock, AR,
Oct. 27-29, 1977.
"In vitro assay for tumor promoters and anti-promoters", Michigan Branch Tissue Culture
Association, MSU E. Lansing, Nov. 11, 1977.
"Pontius Pilate Syndrome, Cancer and Bioethics", Unitarian Universalist Church, Lansing,
Nov. 13, 1977.
"Integrative Theory of Carcinogenesis: The role of genes in carcinogenesis", Dartmouth
Medical School, Nov. 16, 1977.
"Pontius Pilate Syndrome, Cancer and Bioethics", Dartmouth College, Philosophy and
Religion Departments, Nov. 17, 1977.
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186.
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190.
"Carcinogenesis as a mutagenic process" and "Screening for mutagenic activity in
bacteria and mammalian cells", Course in Chemical Carcinogenesis, Seattle, WA, Feb,
11-13, 1978.
"Chemical modification of mutagenesis in mammalian cells", ICN-UCLA Symposia on
DNA Repair Mechanisms, Feb. 20, 1978, Keystone, CO.
"Genes, Pollutants and Human Diseases", joint meeting of Biophysical- American
Physical Society, Washington, DC., Mar. 27, 1978.
Guest lecturer in Dan Bronstein's RD-838 Toxic Substances Law class, Dec. 5, 1977.
"A unified theory of disease", Pre-Dental Club, Apr. 24, 1978, MSU.
"Genetic basis for altering radiation-induced molecular damage in human cells", Biophys,
801 course, Apr. 24, 1978. MSU.
"Cancer Research Today", WOOD-TV (Grand Rapids), May 2, 1978.
"Unified theory of disease", Pre-Med Club, May 2, 1978, MSU.
"Modification of radiation damage in human cells", Dr. J. Nolen's Radiobiology class, May
2, 1978, MSU.
"Integrative theory of carcinogenesis" and "Mutation of carcinogenesis", NCI and
Frederick Cancer Center, Bethesda, MD, May 11-12, 1978.
"Pontius Pilate Syndrome, Cancer and Bioethics", Dr. Schiamberg's class, Family and
Child Sciences, FSC 820, Oct. 11, 1978.
"Q-Series lectures, MSU Extension course, Sept. 19-26, 1978, "Cloning and Genetic
Engineering".
"A lay-person's view of cancer", lecture to Zeta Tau Alpha sorority, Sept. 20, 1978.
"Pontius Pilate Syndrome, Cancer and Bioethics", Edgewood College, Madison Wisconsin.
"Development of an in vitro tumor promoter assay", McArdle Laboratory for Cancer
Research.
"The Pontius Pilate Syndrome, Science and Humane Values" to the Alumni Distinguished
Scholarship competitors, Feb. 17, 1978
"Somatic Mutation Theory of Aging", Gordon Research Conference, Santa Barbara, CA.
"In vitro assays for mutagenesis and tumor promotion in mammalian cells".
International Workshop on Environmental Mutagenesis and Carcinogenesis, Buenos
Aires, Brazil.
"In vitro dection of potential tumor promoters", Intern. Workshop "Short- Term Tests for
Prescreening of Chemical Carcinogens", Genova, Italy Feb. 6- 9, 1979.
"Some non-random thoughts on the biological consequences of random mutations in
mammalian cells", Biophysics, Dept. MSU, Apr. 16, 1979.
"Genetics of Human Cancer", MSU, School of Human Medicine, Apr. 13, 1979.
"Development of an in vitro assay for the detection and study of mechanism of tumor
promoters", Biochemistry Dept., MSU, Apr. 30, 1979.
"UV-induction of diphtheria toxin-resistant mutations in xeroderma pigmentosum
fibroblasts", Amer. Assoc. Cancer Research meetings, New Orleans LA, May 19, 1979.
"Inhibition of metabolic cooperation mammalian tissue culture cells by phorbol myristate
acetate". 30th Annual Meeting of Tissue Culture Assoc., Seattle, WA, June 10, 1979
"Potential role of mutagenic and epigenetic mechanisms of aplastic anemia and
leukemia", Conference on Aplastic Anemia: San Francisco, CA, June 17- 19, 1979.
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209.
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214.
"UV-induction of diphtheria-toxin resistant mutations in normal and DNA repair-deficient
human and Chinese hamster fibroblasts". Conf. on DNA Repair and Mutagenesis in
Eukaryotes", Atlanta, June 25-28, 1979.
"Genes, Pollutants and Human Diseases", Conference for Occupational Health for
Workers. Dr. John Revittle, MSU, July 9, 1979.
"Tumor promoting chemicals, their biological effects and their significance as
environmental hazards". U.K. Env. Mutagen Society, Univ. of Sussex, England, Sept. 10,
1979.
"In Vitro Assay for Tumor Promoters", Internat. Conf. on "Short-Term Tests for Chemical
Carcinogens". Vancouver, BC, Aug. 23, 1979.
"Role of Genetic and Environmental Factors in Carcinogenesis", Men's Colloquium, MSU,
Oct. 2, 1979.
"Technological Intervention and the Pontius Pilate Syndrome", Family and Child Sciences
Dept. MSU, Oct. 8. 1979.
"Current Research on DNA Repair in Xeroderma Pigmentosum", Michigan Dermatology
Society, Oct. 10, 1979.
"Role of Genes in Affective Diseases", Dept. of Psychiatry, MSU, Oct. 16, 1979.
"Chemical Promoters":
Amplifiers of Mutted Cells", NIEHS Sub-Committee on
Environmental Mutagenesis, Bethesda, MD, Nov. 5, 1979.
"Role of genetic and environmental factors in carcinogesis and atherosclerosis: A
speculative hypothesis and its implication to prevention". Michigan State Medical Society
Meeting, Detroit, MI, Nov. 15, 1979.
"An integrative hypothesis of carcinogenesis", Univ. of Illinois, Urbana, Nov. 20, 1979.
"Role of DNA repair in mammalian mutagenesis", Univ. of Illinois, Urbana, Nov. 20,
1979.
"Role of mutations and changes in gene expression in the genesis of cancer", Am.
Business Cancer Res. Foundation, NY, Nov. 21, 1979
"An integrative theory of carcinogenesis: Role of mutation and epigenetic changes",
Institute of Cancer Research, Philadelphia, PA, Nov. 27, 1979.
"An integrative theory involving the role of mind and body on chronic diseases".
Psychology Dept. MSU, Jan. 18, 1980.
"Role of mutations and epigenetic changes in carcinogenesis", Oakland Univ.
"Genes, Pollution and Human Diseases", IDC Course at MSU (Dr. D. Johnson), February,
1980.
"Mechanism of Tumor Promoters", Developmental Biology Group, Univ. of Michigan (Dr.
G. Nace).
Symposium address, "In vitro assay for the detection and mechanism of action of tumor
promoters", EMS meeting, Nashville, March, 1980.
"In vitro assay for the detection of tumor promoters", Pesticide Research Center, MSU,
Mar. 24, 1980.
"Integrative theory of carcinogenesis", Delta College, Bay City, MI, Mar. 28, 1980.
"Role of genetics in human cancer", MSU, Medical School, Apr. 7, 1980.
Symposium on sunlight-induced skin cancers, MSU, May 15, 1980.
“Role of mutations and epigenetic changes in carcinogenesis", 814 Pharmacology, MSU
(Dr. Goodman), May 20, 1980.
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"In vitro detection of tumor promoters", NIEHS, Research Triangle Park, NC, June 1-2,
1980.
"Genes, Pollutants, and Human Diseases", Labor and Industrial Relations Meeting,
Wyandott, MI, June 6, 1980.
"Genetic and Environmental Interactions in Human Cancer", Red Cross Nurses meeting,
June 7, 1980.
"PBB: Its potential to human diseases", Conf. on PBB Effects, MSU, June 31, July 1,
1980.
Role of cell-cell communication in tumor promotion. Intern. Symposium on "The
Biological Effects of Tumor Promoters", Schloss Elman, Germany, Oct. 13-16, 1980.
"Pontius Pilate Syndrome". Ethics of Technological Intervention, Dr. L. Schiamberg's
class in Human Ecology (801), Oct. 17, 1980.
"Mechanisms of Aging", Biophysics 501, Dr. E. Eisenstein's class, MSU, Nov. 6, 1980.
"Cancer and Schizophrenia: Dysfunction in cell-cell communication mechanisms",
Neuroscience Program - MSU, Nov. 6, 1980.
"Integrative theory of cancer, atherosclerosis and diabetes", Pathology Department,
MSU, Nov.. 25, 1980.
Symposium speaker "Use of mammalian cell mutants to study the mechanisms of
carcinogenesis", Japanese Tissue Culture Society meeting, Tokyo, Japan, Dec. 4-6,
1980.
"Workshop on the mechanisms of tumor initiation and promotion". Tumor promoters
inhibit cell-cell communication. Ishe-Shima, Japan, Dec. 8-9, 1980.
Seminar speaker, "Role of mutagenesis and cell-cell communication in carcinogenesis",
Univ. of Kyoto Medical School, Kyoto, Japan, Dec. 11,1980.
"The Role of Mutations and Epigenetic Changes in the Aging Process". Lectures to Dr. J.
Meites' Phy. 901 class on "Aging", Jan. 19, 21, 1981.
Theories of Aging to the Lansing Women's Club, Jan. 16, 1981.
"The Role of Mutations and Epigenetic Changes in the Aging Process", Amer. Assoc. Adv.
Science, Toronto, Canada, Jan. 5, 1981.
Genetic Predispositions to Cancer. National Science Class H-172, Dr. Helen Hiscoe, Jan.
27, 1981.
Invited visiting lecturer, "Genetic factors influencing the initiation and promotion stages
of human carcinogenesis". St. Jude's Cancer Hospital, Feb. 5, 1981.
Invited lecturer, "What is cancer and how might it be prevented". East Lansing Jr. High
School, Feb. 12, 1981.
Invited workshop lecturer to the Mechanisms of Carcinogenesis ICN-UCLA Symposia,
"Role of error-prone DNA replication in mammalian mutagenesis/carcinogenesis
intiation". Keystone, CO, Feb. 24, 1981.
Seminar on "Genetic toxicology: Mechanisms and implications for screening" MSU
Toxicology Center, Mar. 11, 1981.
Workshop lecturer, "Carcinogenic, mutagenic and teratogenic workshop", Consequences
of mutations and inhibited cell-cell communication by radiation and various
chemotherapeutic agents". Bethesda, MD, Apr. 13-15, 1981.
Invited lecturer, "Genetic insights to the carcinogenic process". Univ. of Arizona, Dr. T.
Bowden's class, Apr. 18-22, 1981.
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257.
258.
Invited lecturer, "Mechanisms and consequences of mutagenesis in human beings",
Univ. of Michigan School of Medicine, May 11-12, 1981.
"Why Cancer?" - Michigan Children's Leukemia Foundation Symposium, July 11, 1981,
MSU.
Seminar on "Hormones as tumor promoters", Endocrinology Unit, MSU, Sept. 18, 1981.
"Science and Humanism", Dr. Judy Funston's English class.
"Genetic and Environmental Determinants in Human Carcinogenesis", Workshop on
Medical Oncology, Mott Children's Health Center, Flint, Nov. 20, 1981.
"Carcinogenesis: An Overview". Michigan State Medical Society meetings, Detroit, MI,
Nov. 19, 1981.
"New Theories of Aging", East Lansing Women's Club, Jan. 20, 1982.
"Role of inhibited intercellular communication in teratogenesis, tumor promotion and
reproductive dysfunction". Zoology Dept. MSU, Jan. 25, 1982.
Invited lecturer, "The role of intercellular communication in carcinogenesis", Anatomy
891, Dr. C. Welsch, Feb. 2,4, 1982.
Invited speaker, "Mechanisms of congenital defects", Pediatric Clerkship, MSU, Feb. 8.
1982.
Invited symposium speaker, "Role of intercellular communication in human diseases",
The Toxicology Forum, Feb. 15, 1982.
Invited speaker, "Genetic and environmental determinants of human cancer", Ingham
County Medical Society, Feb. 16, 1982.
Invited lecturer, "Genes, Pollutants, and Human Diseases", Resource Ecology and Man
course, Feb. 22, 1982.
Invited symposium speaker, "PCB's as Potential Tumor Promoters", Intern. Academic
Science meeting, Mar. 26, 1982.
Invited symposium speaker, "In vitro assays to detect teratogens", Michigan Academic
Science meeting, Mar. 26, 1982.
Invited seminar, "Role of inhibited intercellular communication in the promotion phase of
carcinogenesis", Oak Ridge National Laboratory, Apr. 8, 1982.
Guest lecturer in "The Uniqueness of Men", course by Dr. W. Cooper, "Mechanism of
Cancer--The Cost of the Wrong Message", Apr. 21, 1982.
Northeastern Michigan Pediatric Society, Frankenmeuth, MI, May 12, 1982, "Genetic and
Environmental Factors in Childhood Cancers".
Invited speaker, "Role of inhibited intercellular communication in tumor promotion and
teratogenesis", Midwest Regional Society of Toxicology, Northwestern University, May,
1982.
Invited speaker, "New in vitro assay to detect chemicals which inhibit intercellular
communication". Travenol Medical Supply Co., Chicago, IL, May 1982.
Invited speaker, Owosso Memorial Hospital, "Environmental chemicals and human
cancers", June 1, 1982.
Symposium speaker, "Chemical distributors of intercellular communication as teratogens,
tumor promoters and reproductive toxins". Toxicology in Michigan Today, Lansing,
June, 1982.
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Symposium speaker, "Genetic and environmental factors in childhood cancers", 3rd
Annual Children's Leukemia Foundation of Michigan, Univ. of Michigan, Ann Arbor, June
5, 1982.
Genotoxic and epigenetic mechanisms in carcinogenesis. SGOMSEC Workshop on
"Quantitative Estimation of Risk to Human Health from Chemicals", Rome, Italy, July
12-16, 1982.
Invited speaker, "In vitro detection of chemical tumor promoters". Michigan Cancer
Foundation, Detroit, July 26, 1982.
Invited lecturer for the Summer Institute for Gifted Students, August 3,4,5,6, and 10th,
MSU. "Creativity in Science and Art", "Science and the Future" and "Science and Human
Nature".
Invited seminar, "Role of inhibited intercellular communication in tumor promotion and
teratogenesis". Haskell Laboratories--Dupont Chemical, Wilmington, DE, Aug. 23, 1982.
Invited speaker at Round Table, "Mechanisms of Tumor Promotion", 13th International
Cancer Congress, Seattle, WA, Sept. 15, 1982.
Invited symposium speaker, New York Academy of Science, Oct. 6, 1982, New York.
Invited seminar speaker, "Role of mutations and epigenetic changes in carcinogenesis",
Rutgers University, New Brunswick, NJ, Oct. 8, 1982.
Invited speaker, "In vitro assays to detect tumor promoters".
Pharmaceutical
Manufacturers Assoc., Captiva Island, FL, Oct. 12, 1982.
Invited speaker, "Inhibited intercellular communication: Its implications to health and
disease". Upjohn Pharmaceutical Co., Kalamazoo, MI, Nov. 18, 1982.
Invited seminar speaker, "Chemical inhibition of intercellular communication in
hyperplasia and tumor promotion". Pathology Dept. MSU, Nov. 23, 1982.
Invited speaker, "Transplacental toxicology: Clues to the teratogenesis/ carcinogenesis
connection". American College of Obstetricians and Gynecologists, Lansing, MI, Feb.
10, 1983.
Invited lecturere for Dr. Dave Johnson's IDC course on "Man and his environment".
Topic--Interaction of human genes with human chemicals. Feb. 21, 1983.
Invited seminar speaker, Ohio State University School of Medicine, "Oncogenes,
Mutations and Inhibited Intercellular Communication". Mar. 4, 1983.
Invited seminar speaker, Biomedical Science Center's "Biomed Super Saturday
Symposium, "Genes, Pollutants and Human Diseases", May 7, 1983.
Invited symposium speaker, "Short-term test for tumor promoters using inhibited
intercellular communication", International Symposium on Role of Cocarcinogens and
Promoters in the Human and Experimental Carcinogenesis". Budapest, Hungary, May
16-18, 1983.
Invited symposium speaker, "Carcinogenesis research--An overview", and "A possible
mechanistic link between teratogenesis and carcinogenesis: Inhibited intercellular
communication: International Symposium "Mechanisms of Mutagenesis, Carcinogenesis
and Teratogenesis, Shanghai, China, May 25-June 1, 1983.
Minicourse on Genetics and Carcinogenesis, Nanjing Assoc. of Science and Technology.
Nanjing TEachers College, June 3-9, 1983.
Invited speaker, "Mechanisms of carcinogenesis". National Academy of Medicine, Beijing
Cancer Institute, Beijing, China, June 14, 1983.
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Invited seminar speaker at McNeil Pharmaceutical Laboratories. "In vitro assay to detect
potential tumor promoters and teratogens"., Philadelphia, PA, June 23, 1983.
Invited lecturer to the Summer Institute for the Arts and Sciences, MSU "Creativity in the
Arts and Sciences". Science and the Nature of Human Nature, Science and Cancer",
Aug. 3 and 11th 1983.
Invited seminar speaker, Pharmaceutical Manufacturers Association: "Adaptive and
non-adaptive consequences of chemical inhibition of intercellular communication, Sept.
18-21, 1983.
Invited seminar speaker, MSU Carcinogenesis Colloquium. "Fetal hydantoin syndrome:
Clues to the carcinogenesis/teratogenesis connection". Oct. 11, 1983.
Invited seminar speaker, Univ. of Vermont. "Oncogenes, intercellular communication
and tumor promotion". Burlington, VT, Oct. 19-21, 1983.
Invited symposium speaker, "Oncogenes, intercellular communication and tumor
promotion", Princess Takamatsu Symposium on "Mechanisms of Tumor Promotion",
Tokyo, Japan, Nov. 14-18, 1983.
Invited symposium speaker, International Congress of Genetics, "Mechanism of
Mammalian Mutagenesis", New Delhi, India, Dec. 17, 1983.
Invited seminar speaker "Chemical inhibition of intercellular communication: Implication
for teratogenesis, tumor promotion and reproductive toxicology", Institute of
Environmental Health, Univ. of Cincinnati Medical Center, Cincinnati, OH, Mar. 7, 1984.
Invited seminar speaker, "Oncogenes, inhibited intercellular communication", McMaster
University, Hamilton, Ontario, Mar. 13-14, 1984.
Invited seminar speaker, "Oncogenes, inhibited intercellular communication and tumor
promotion". Oncology Group, Dept. of Medicine, MSU, Mar. 21, 1984.
Invited seminar speaker, "Mechanisms of teratogenesis", OB/GYN Dept., MSU, Apr. 28,
1984.
Invited symposium speaker, "Mechanisms of human cellular promotion", Ohio State
University, Apr. 28, 1984.
Invited seminar speaker, "Potential role of inhibited intercellular communication in
teratogenesis, carcinogenesis and reproductive toxicology", Univ. of Rochester,
Toxicology Group, Rochester, NY, May 7, 1984.
Poster session, "Potential role of src gene production in the inhibition of gap-junctional
intercellular communication", Amer. Assoc. Cancer Research, meeting, Toronto, Canada,
May 9-12, 1984.
Invited lecturer, "Role of intercellular communication in carcinogenesis", Dept. of
Pharmacology, MSU, May 18, 1984.
Invited symposium speaker, "Role of tumor promotion in the multi-step nature of
carcinogenesis". Brookhaven National Laboratory, May 20-17,1984.
Invited symposium speaker, "Detection of non-mutagenic and non-cytotoxic hazardous
chemicals". Tissue Culture Assoc. Meeting, Houston, TX, June 3- 4, 1984.
Invited After-Dinner Speaker, "Adaptive and non-adaptive consequences of inhibited
intercellular communication", 12th Annual Pharmacology Research Colloquium, MSU,
June 22, 1984.
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Invited seminar speaker, "Consequences of inhibition of intercellular communication by
toxic chemicals:
Relevance to teratogenesis, carcinogenesis and neural and
reproductive toxicology", Animal Science Dept. MSU, Nov. 5, 1984.
Invited seminar speaker, "Problems in Communicating Science to the Public via Science
Reporters". Science Reporters Mtg., MSU-Adm. Bldg., Nov. 30, 1984.
Invited seminar speaker, "Chemical Inhibition of Intercellular Communication; Its Broad
Role in Toxicology", Dept. of Environ. & Indus. Hlth., Univ. of Mich., Ann Arbor, MI, Feb.
15, 1985.
Invited workshop lecturer, "Mechanisms of Carcinogenesis, Mutagenesis and
Teratogenesis". Environmental Toxicology Seminar, Monroe County Health Dept.,
Farmington Hills, MI, Feb. 19 and 20, 1985.
Sigma Xi Senior Research Award Address, "Inhibited Intercellular Communication: A
New Paradigm for Studies of the Diseases of the Mind and Body", Biochemistry Dept.,
April 25, 1985.
Invited lecturer, "Role of Chemical and Oncogene Inhibited Intercellular Communication
in Toxicology", Dow Chemical Company, Midland, May 3, 1985.
Symposium speaker, "In vitro Detection of Chemicals Which Inhibit Intercellular
Communication", Central Regional Mtg., American Chemical Society, Akron, OH, June 5,
1985.
Invited international symposium speaker, "Oncogene and Chemical Inhibition of
Gap-Junctional Intercellular Communication;
Implications for Teratogenesis and
Carcinogenesis", 4th Inter. Conf. Environ. Mutagens, Stockholm, Sweden, June 24-28,
1985.
Invited seminar speaker, "The possible integrating role of chemical inhibition of
intercellular communication in various human chronic diseases. Dept. of Medicine, MSU,
January 8, 1986.
Invited lecturer, "Regulatory implications of the current understanding on the nature of
toxic chemicals. Lyman Briggs College, April 3, 1986.
Invited seminar speaker, "Fluorescence Recover After Photobleaching: A new technique
to measure cell-cell communication. DOW Chemical Lab., June 1985.
Invited seminar speaker, "Adaptive and Nonadaptive Consequences of Chemical
Inhibition of Intercellular Communication”. Columbia University College of Physicians
and Surgeons, April 7, 1986.
Invited seminar speaker, "Oncogenes Inhibited Intercellular Communication and
Carcinogenesis”. Dept. Path., New York University Medical Center, April, 8, 1986.
Invited seminar speaker, "New Methods to Detect Chemical Inhibitors of Intercellular
Communication”. R.J. Reynolds Lab., Winston-Salem, NC, May, 1986.
Invited seminar speaker, "Possible role of chemical inhibition of gap junctional
communication in brain cells causing neurotoxic effects”. Dept. of Radiology, MSU, July
7, 1986.
Invited guest lecturer, "Creativity in the Arts and Sciences”. Gifted Students Workshop,
Grand Valley College, July 14, 1986.
Invited lecturer, "Scientific concepts of human nature and their implications to health
care policy”. Dr. L VanEgeren's Behavioral Medicine course (CHM570), Oct. 8, 1986.
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Invited seminar speaker, "Can there be a unified theory of diseases?" Dean's hour
lecture to medical students, MSU, Oct. 10, 1986.
Invited seminar speaker, "New strategies for cancer chemotherapy: Getting cancer cells
to talk to normal cells”. Dept. of Medicine Oncology group, MSU, Oct. 16, 1986.
Invited seminar speaker, "New insights on cancer”. Lansing Graduate and Professional
Singles Club, Nov. 13, 1986.
Invited symposium speaker, "Role of intercellular communication in aging”. Conference
on Research on Aging," Kellogg Center, MSU, Nov. 17, 1986.
Invited seminar speaker, "Pharmacological and toxicological effects of chemical
modulation of gap junction function”. Dept. of Pharmacology and Toxicology, MSU, Nov.
18, 1986.
Invited symposium speaker, "The role of inhibition of DNA polymerase A in DNA
amplification in Chiniese hamster cells”.
Symposium at the Deutsches
Krebsforschungszentrum, Heidelberg, Germany, Oct. 24-26, 1986.
Invited seminar speaker, "Inhibition of gap junctional communication by chemicals and
oncogenes during carcinogenesis”. Boston University School of Medicine, Dec. 4, 1986.
Invited seminar speaker, "Oncogenes, inhibition of intercellular communication and
tumor promotion”. University of Pennsylvania, Philadelphia, Dec. 5, 1986.
Invited seminar speaker, "Oncogenes, intercellular communication and tumor
promotion”. Dept. of Biochemistry, Emory University School of Medicine, Dec. 12, 1986.
Invited lecturer, "A new medical paradigm: The germ theory is dead”. Dr. L. Van
Egeren's course. Jan. 21, 1987.
Invited lecturer, "Genetic susceptibility to cancer”. Dr. C. Welsch's course, "Theories in
Carcinogenesis", MSU, Feb. 12, 1987.
Invited lecturer, "Cell-cell communication and cancer”. Dr. C. Welsch's course, "Theories
in Carcinogenesis", MSU, Feb. 14, 1987.
Invited speaker, "New Concepts in Understanding Cancer," MSU Retiree's Club, March
31, 1987.
Invited seminar speaker, "Oncogenes, Growth Factors and Tumor Promoters: An
integrated hypothesis involving inhibition of gap junctional communication. Univ. of
Texas Cancer Center, Science Park, Texas, April 14, 1987.
Invited symposium speaker, "Non-genotoxic mechanisms in carcinogenesis: role of
inhibited intercellular communication". Bambury Conference, Cold Spring Harbor, NY,
Oct. 11, 1987.
Invited symposium speaker, "Chemical modulation of gap junctional communication:
Implications for varied toxicologic responses". Northeast Regional Society of Toxicology
Mtg., Boston, Oct. 23, 1987.
Invited speaker, "Genetic and environmental factors influencing cancer". Mich. Chapter
American Academy of Optometry, East Lansing, MI, Oct. 28, 1987.
Seminar speaker, "Chemical, oncogene and growth factor modulation of gap junctional
communication". Dept. of Physiology, M.S.U., East Lansing, MI, Oct. 29, 1987
Invited lecturer, "Possible role of gap junctional intercellular communication in linking
the mind with the body". Psychology Interns, M.S.U., East Lansing, MI, Nov. 3, 1987.
Invited seminar speaker, "Oncogenes, chemical tumor promoters and gap junctions: an
integrated theory of carcinogenesis". Frederick Cancer Res. Facility, Dec. 9, 1987.
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Invited seminar speaker, "Mechanism of carcinogenesis: A challenge to the current
paradigm of carcinogenesis". Brookings Institute, Washington, DC, Jan. 12, 1988.
Invited lecturer in "Topics in Toxicology" series, "Inhibited intercellular communication:
Its possible role in teratogenesis, carcinogenesis, neurotoxicity and reproductive
dysfunction". Coriell Institute for Medical Research, Camden, NJ, Jan. 14, 1988.
Invited seminar speaker, "Inhibition of gap junctional communication: Implications for
varied toxicologic effects". Univ. of Connecticut, Storrs, CT, Jan. 15, 1988.
Invited distinguished science speaker, "Oncogenes, chemical tumor promoters and
growth factors: An integrative theory of carcinogenesis". Medical College of Ohio,
Toledo, OH, Jan 20, 1988.
Invited symposium speaker, "Abnormal intercellular communication: Implications for
cause and cure of cancer". National Surgical Adjuvant Project for Breast and Bowel
Cancers, Tampa, FL, Jan. 24, 1988.
Invited seminar speaker, "The role of inhibited intercellular communication in
carcinogenesis: Implications for risk assessment to exposure to chemicals". Oak Ridge
National Laboratory, Oak Ridge, TN, Jan. 27, 1988.
Invited seminar speaker, "Chemical inhibition of gap junctional communication:
Implications for toxicology". Toxicology Program, University of Wisconsin, February,
1988.
Invited seminar speaker, "Chemical tumor promoters, oncogenes and growth factors:
An integrated theory of carcinogenesis". Wayne State Univ., March 9, 1988.
Invited symposium speaker, "Role of inhibited intercellular communication in
carcinogenesis:
Implications for risk assessment from exposure to chemicals.
Bioindicators: Exposure and Effects". Oak Ridge, Tennessee, March 20-22, 1988.
Invited speaker for the "Frontiers in Biological Sciences" Lecture series, "Oncogenes,
growth factors and chemical tumor promoters: An integrated hypothesis involving
inhibitors of gap junctional communication". Case Western Reserve University, College
of Medicine, April 6, 1988.
Invited lecturer, "Chemical modulation of gap junctional intercellular communication:
Implications for Toxicology". Case Western Reserve, Dept. of Environmental Health
Sciences, April 7, 1988.
Invited seminar speaker, "Intercellular communication and cancer: Role of oncogenes,
chemical tumor promoters and growth factors". Rosewell Park Memorial Institute,
Buffalo, NY, May 4, 1988.
Invited symposium speaker, "Role of oncogenes, chemical tumor promoters and growth
factors in the modulation of intercellular communication during carcinogenesis”.
American Oil Chemist Society Mtg., Phoenix, AZ, May 10, 1988.
Invited lecturer, "Modulation of gap junctional intercellualr communication:
Pharmacological and toxicological implications". Sterling- Winthrop Research Institute,
Albany, NY, May 18, 1988.
Invited seminar speaker, "Toxicological implications of chemical inhibition of gap
junctional communication”. Natl. Center for Toxicological Research, Jefferson, Arkansas,
August 8, 1988.
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Invited symposium speaker, "Mechanisms and consequences of chemical modulators of
intercellular communication studied by interactive laser cytometry". Soc. Analytical
Cytology Intern. Symposium, Breckenridge, CO, Sept. 4-9, 1988.
Invited seminar speaker, "Influence of chemical tumor promoters, oncogenes and
growth factors on gap junctional communication and carciogenesis". Univ. of Colorado
Health Science Center, Sept. 8, 1988.
Invited symposium speaker, "Dietary modulators of intercellular communication in
carcinogenesis and atherogenesis". American College of Nutrition Mtg., New Orleans,
Sept. 16, 1988.
Invited Discussant, "Role of inhibited intercellular communication in pancreatic
carciogenesis". Pancreas Cancer Working Group Mtg., Bethesda, Septt. 19-20, 1988.
Invited seminar speaker, "Oncogenes, chemical tumor promoters and growth factors:
An integrated theory of carcinogenesis". Univ. of Kansas, Kansas City, Oct. 26-27, 1988.
Invited symposium speaker, "Stem cell theory of cancer". 18th Conference on
Toxicology - H. Armstrong Aerospace Medical Res. Lab., Dayton Ohio, Nov. 1-3, 1988.
Invited seminar speaker, Cornell University, Ithaca, New York, Nov. 15, 1988.
Invited symposium speaker, "Cell-cell communication in carcinogenesis". Mouse Liver
Carcinogenesis Mtg., Austin, Texas, Nov. 31 - Dec.2, 1988.
Invited speaker, "Scientific basis for epigenetic toxicology: A possible resolution of a
crisis in risk assessment models". ILSI Foundation Mtg., Bahamas, Jan. 18, 1989.
Invited seminar speaker, "Epigenetic Toxicology: The implications to risk assessment”.
Monsanto Chemical, St. Louis, Feb. 13, 1989.
Invited seminar speaker, "Chemical modification of intercellular communication:
Implications for nongenotoxic toxicity". Program in Toxicology seminar series, Rutgers
University, New Jersey, March 8, 1989.
Invited seminar speaker, "Chemical promoters, oncogenes, and growth factor
modulation of intercellular communication: A unified theory". Loma Linda, California,
March 21, 1989.
Invited symposium speaker, "Inhibition of intercellular communication during radiation
and chemical carcinogenesis. Radiation Research meeting, Seattle, Washington, March
27, 1989.
Invited workshop speaker, "Promotion as a factor in risk assessment". Carcinogen Risk
Assessment, Society for Risk Analysis, Wash. D.C., April 4, 1989.
Invited symposium speaker, "Oncogenesis and abnormal intercellular communication
and its implication to the cause and prevention of carcinogenesis", and "Clinical
implications of intercellular communication on wound healing". Quebec Association of
General Surgeons, Quebec City, Canada, May 4-5, 1989.
Invited seminar speaker, "Oncogenes, tumor promoters and growth factor inhibition of
intercellular communication: Integrative theory of cancer". University of Hamburg,
Germany, July 17, 1989.
Invited symposium speaker, "Mechanisms of chemical and oncogene modulation of gap
junctional communication during carcinogenesis". Molecular Cell Biology of Gap
Junctions Symposium, Irsee, Germany, July 18-23, 1989.
Invited symposium speaker, "In vitro analysis of modulators of intercellular
communication: Implications to mechanisms of tumor promotion and to predictions of
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potential tumor promoters". Practical In Vitro Toxicology Symposium, University of
Nottingham, England, July 23-27, 1989.
Invited symposium speaker, "Chemical and oncogene modulation of intercellular
communication during carcinogenesis". Symposium on Molecular, Cellular Biology of
Liver Growth and Function, Lake Placid, NY, Aug. 13-16, 1989.
Invited seminar speaker, "Oncogenes,, tumor promoters, and growth factors: An
integrative theory of carcinogenesis”. Eppley Cancer Center, Univ. of Nebraska, Omaha,
Sept. 28, 1989.
Invited seminar speaker, "Role of chemical inhibition of gap junctional communication in
pharmacological and toxicological effects of drugs". Bristol Myers, Syracuse, NY, Oct. 9,
1989.
Invited symposium speaker, "Modulated intercellular communication: Consequence of
extracellular molecules triggering intracellular communication”.
Eicosanoids and
Bioactive Lipids in Cancer and Radiation Injury”. Detroit, MI, Oct. 11-14, 1989.
Invited seminar speaker, "Modulation of gap junctional communication: Pharmacological
and Toxicological Implications”. Parke Davis-Warner Lambert, Ann Arbor, Oct. 17, 1989.
Invited seminar speaker, "A crisis in paradigms: The roles of genotoxic versus epigenetic
mechanisms in toxicology”. Environmental and Industrial Health Department, Univ. of
Michigan, Ann Arbor, MI, Dec. 1, 1989.
Invited seminar speaker, "Chemical inhibition of intercellular communication:
Implication to diverse fields of toxicology”. Univ. of Cal.-Riverside, March 12, 1990.
Invited seminar speaker, "Oncogenes, tumor promoters and growth factor modulation of
intercellular communication: Integrative theory of carcinogenesis”. Noble Foundation,
Ardmore, OK, May 17, 1990.
Invited symposium speaker, "Chemical modulation of intercellular communication as a
factor in risk assessment”. New Directions in Carcinogen risk assessment symposium,
Bethesda, MD, May 21-23, 1990.
Invited seminar speaker, "Oncogenes, tumor promoters, and growth factor modulation
of intercellular communication: An integrative theory of carcinogenesis”. University of
North Carolina, Department of Pathology, Chapel Hill, NC, July 11, 1990.
Invited symposium speaker, NIEHS Conference on "Agricultural chemical utilization and
human health”. Research Triangle Park, NC, July 12-13, 1990.
Invited seminar speaker, "A new integrative view of the mechanisms of carcinogenesis:
The roles of stem cells, oncogenes and invironmental factors”. ATOMIC Disease
Institute, Nagasaki Medical Schook, Nagasaki, Japan, 1990.
Invited seminar speaker, "A new integrative view of the mechanisms of carcinogenesis:
The roles of stem cells, oncogenes and environmental factors”. Radiation Effects
Research Foundation, Hiroshima, Japan, 1990.
Invited symposium speaker, "Modulation of intercellular communication in vitro:
Implications for radiation research”. International Meeting on "In Vitro Toxicology: An
Alternative to Animal Testing," Les Pensieres, France, October 17-19, 1990.
Invited symposium speaker, "Role of stem cells, oncogenes and cell-cell communication
in radiation carcinogenesis”. Japanese Radiation Research Society, Sendai, Japan,
October 26, 1990.
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Invited seminar speaker, "Role of stem cells, oncogenes and cell-cell communication in
radiation carcinogenesis”. Department of Radiation Biology, Kanazawa University,
Kanazawa, Japan, October 29, 1990.
Invited symposium speaker, "Chemical, oncogene, and growth factor modulation of
intercellular communication during radiation carcinogenesis" at the symposium on
"Oncogenic Mechanisms in Radiation-Induced Cancer," Fort Collins, CO, January 16-19,
1991.
Honored 3rd Van R. Potter lecturer, "The possible role of oncogenes and intercellular
communication in the 'oncogeny as partially blocked ontogeny' hypothesis”. McArdle
Laboratory for Cancer Research, University of Wisconsin, Madison, WI, January 22,
1991.
Invited lecturer, "Modulation of gap junctional intercellular communication by oncogenes
and chemicals: Implications for carcinogenesis and chemotherapy”. Bristol-Myers
Squibb, Syracuse, NY, January 24, 1991.
Invited symposium speaker, "Oncogenes, tumor suppressor genes and cell-cell
communication in human radiation carcinogenesis," at "The Future of Human Radiation
Research Symposium", Elmau, Germany, March 4-8, 1991.
Invited workshop speaker, "Possible role of intercellular communication in the
modulation of the biological response to radiation”. Biological Effects of Low Dose
Radiations, Workshop, Yokohama City University School of Medicine, March 12, 1991.
Invited seminar speaker, "Implications of research on cell-cell communications for
understanding human diseases”. Nippon Shinyaku Pharmaceutical Company, Kyoto,
April 8, 1991.
Invited symposium speaker, "Modulation of intercellular communication by tumor
promoters, oncogenes and tumor suppressor genes: Implications for human radiation
carcinogenesis”. Second Wonkwang Symposium on Cytometry, Wonkwang University,
Iri, Korea, May 10 1991.
Invited symposium speaker, "Modulation of intercellular communication by tumor
promoters, oncogenes and tumor suppressor genes during radiation carcinogenesis”.
Korean Society of Molecular Biology," Iri, Korea, May 11, 1991.
Invited workshop speaker, "Use of laser-image cytometry to study the mechanisms of
carcinogenesis”. Flow and image cytometry workshop, University of Iri, Korea, May 13,
1991.
Invited lecturer, "Role of modulated intercellular communication in health and disease
states”. Wonkwang University School of Medicine, Iri, Korea, May 13, 1991.
Invited symposium speaker, "Is ionizing radiation a deletion mutagen and a cytotoxicant,
rather than a point mutagen in radiation carcinogenesis?" International Symposium on
Environmental Mutagenesis and Carcinogenesis. Shanghai, China, May 27-29, 1991.
Invited symposium speaker, "Oncogenes, suppressor genes and gap junctions: An
integrative theory of radiation carcinogenesis”. Symposium on Mechanisms in Cellular
Neoplastic Transformation. University of California-Irvine, June 18, 1991.
Invited symposium speaker, "Chemical, oncogene and growth factor modulation of
intercellular communication during radiation carcinogenesis”. World Congress on
Medical Physics and Biomedical Engineering, Kyoto, Japan, July 7-12, 1991.
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Invited symposium speaker, "Modulation of gap junction function: The scientific basis for
epigenetic toxicology”. International Conference on Environmental and Industrial
Toxicology, Chulabhorn Research Institute, Bangkok, Thailand, July 22-26, 1991.
Invited Lecturer, "Chemical oncogene and growth factor modulation of intercellular
communication during radiation carcinogenesis”. 24th Biwako Symposium, Lake Biwako,
Japan, August 18, 1991.
Invited seminar speaker, "Gap junctions, oncogenes and carcinogenesis”. Los Alamos
National Laboratory, NM, September 4, 1991.
Invited workshop speaker, "Role of radiation and oncogene modulation of cell to cell
communication in carcinogenesis”. Second Gap Junction Research Workshop, Tokyo,
Japan, October 14, 1991.
Invited symposium speaker, "Role of modulated cell communication, oncogenes, tumor
suppressor genes and chemicals during radiation carcinogenesis”. Japan Cell Biology
Meeting, Fukuoka, November 21, 1991.
Invited seminar speaker, "Chemical tumor promoters, oncogenes and tumor suppressor
genes in carcinogenesis”. Hiroshima Red Cross Hospital, November 27, 1991.
Invited Lecturer, "Stem cells, intercellular communication and cancer genes in radiation
carcinogenesis”. Hiroshima University School of Medicine, Japan, December 13, 1991.
Invited seminar speaker, "Role of stem cells and tumor suppressor genes in radiation
carcinogenesis”. University of Nagasaki School of Medicine, Nagasaki, Japan, January
10, 1992.
Invited seminar speaker, "Role of oncogenes and tumor suppressor genes in radiation
carcinogenesis”. University of Tokyo, February 20, 1992.
Invited symposium speaker, "How can ionizing radiation affect the multi-stage nature of
human cancer?" European Late Effects of Radiation Project Group, Ulm, Germany,
February 24-27, 1991.
Invited seminar speaker, "Modulation of intercellular communication by oncogenes,
tumor suppressor genes and chemical tumor promoters during carcinogenesis”.
National Cancer Center Research Institute, Tokyo, Japan, April 15, 1992.
Invited seminar speaker, "Modulation of intercellular communication by tumor
promoters, oncogenes and tumor suppressor genes during carcinogenesis”. Nara
Medical University, Nara, Japan, April 20, 1992.
Invited seminar speaker, "The pharmacological and toxicological aspects of chemical
modulation of cell to cell communication”. Ohtsuka Pharmaceutical Co., Ltd., Ohtsu,
Shiga, Japan, May 26, 1992.
Invited symposium speaker, "Laser cytometry in the study of the roles of tumor
promoters, oncogenes and tumor suppressor genes”.
IUBMB-Conference on
Biochemistry of Diseases, Nagoya, Japan, June 1-6, 1992.
Invited symposium speaker, "Oncogenes, tumor suppressor genes and intercellular
communication: Implications for the cause and treatment of cancer”. 55th Hiroshima
Society for Cancer Therapy, Hiroshima, Japan, June 7, 1992.
Invited symposium speaker, "Oncogenes, tumor suppressor genes and intercellular
communication, in the 'oncogeny as partially blocked ontogeny' hypothesis”.
Symposium on Theories of Carcinogenesis, Oslo, Norway, August 15-21, 1992.
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417.
418.
419.
420.
421.
422.
423.
424.
425.
426.
427.
428.
Invited seminar speaker, "Does radiation cause cancer: Studies from Hiroshima”.
Pharmacology/Toxicology Department, MSU, October 13, 1992.
Invited seminar speaker, "The long-term somatic and hereditary effects of radiation on
the Hiroshima/Nagasaki survivors and their offspring”. Cancer Center, MSU, October 20,
1992.
Invited seminar speaker, "Current results of the study of A-bomb survivors and their
offspring”. M.D.-Ph.D. program, college of Osteopathic Medicine and College of Human
medicine, MSU, November 11, 1992.
Invited seminar speaker, "Long-term effects on the health of A-bomb survivors and their
offspring”. Hurley Hospital, Flint, MI, February 5, 1993.
Invited seminar speaker, "The ethical and scientific aspects of the studies on the Abomb survivors of Hiroshima/Nagasaki”. Medical Humanities Group, MSU, February 12,
1993.
Invited seminar speaker, "The long-term effects of radiation on the A-bomb survivors
and their offspring”. Department of Medicine, MSU, March 2, 1993.
Invited lecturer, "Role of cell-cell communication in carcinogenesis”. PHM815 course in
"Concepts in Tumorigenesis," MSU, March 23, 1993.
Invited seminar speaker, "The effects of A-bomb radiation on children and offspring of
the survivors”. Department of Pediatrics, MSU, March 25, 1993.
Invited seminar speaker, "The role of intercellular communication in the carcinogenic
process”. Department of Surgery, MSU, May 27, 1993.
Invited symposium speaker, "Characterization of gap junctional communication in
normal human breast epithelial cells and in breast cancer cells transformed with various
connexin genes”. International Symposium on Gap Junctions, Hiroshima, Japan, August
24-27, 1993.
Invited seminar speaker, "Pharmacological and toxicological implications of modulated
gap junctional communication”. Nippon Shinyaku Pharmaceuticals, Kyoto, Japan,
August 30, 1993.
Invited seminar speaker, "Oncogenes, tumor suppressor genes and gap junctional
communication in the carcinogenic process”. University of Tokyo, College of Dentistry,
Tokyo, Japan, September 1, 1993.
Invited seminar speaker, "Tumor promoters and anti-tumor promoters in the modulation
of gap junctions during carcinogenesis”. Mitsubishi Kasei Corporation, Yokohama,
Japan, September 3, 1993.
Invited seminar speaker, "New evidence of the role of inhibited intercellular
communication in carcinogenesis”. Breast Cancer Group, MSU, September 16, 1993.
Invited lecturer, "How cells talk to each other and what happens when they do not”.
Michigan High School Science Teachers Project, MSU, September 17-18, 1993.
Grand Rounds Seminar, "Are pesticides a pediatric problem?: What are the scientific
elements of concern?" Kellogg Center, MSU, Sept. 23, 1993.
Workshop lecturer, "Disruption of homeostasis as the basis of potential health effects of
cellular telephones," Workshop on Cellular Telephone Research and Cancer,
Washington, D.C., Dec. 13-15, 1993.
Invited lecturer, "Role of Intercellular communication in toxicology," PHM814 course,
"Advanced Principles of Toxicology," MSU, March 25, 1994.
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435.
436.
437.
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439.
440.
441.
442.
443.
444.
445.
446.
Invited lecturer, "Concepts in Carcinogenesis," MSU Medical School, April 12, 1994.
Invited seminar speaker, "Role of oncogenes and tumor suppressor genes in the
regulation of gap junctional intercellular communication," Oak Ridge National Laboratory,
Oak Ridge, Tennessee, April 14, 1994.
Invited seminar speaker, "Nongenotoxic biomarkers: Potentials and limitations," DOE
Symposium on Biomarkers, Santa Fe, NM, April 26-29, 1994.
Invited lecturer, "Nature's cellular phone," Biology Teachers Alliance, MSU, May 17,
1994.
Invited symposium speaker, "Nature's cellular phone and chemoprevention:
Communications between oncogenes and tumor suppressor genes," NSABP meeting,
Nashville, TN, June 13, 1994.
Invited symposium speaker, "Factors involved in radiation-induced cancers," World
Congress on Medical Physics and Biomedical Engineering, Rio de Janeiro, Brazil, Aug.
21-26, 1994.
Invited symposium speaker, "Biomarkers for low-level exposure causing epigenetic
responses in stem cells", at "Biological indicators of exposure to ionizing radiation"
symposium at Schloss Reisenberg, Germany, Sept. 26-30, 1994.
Invited workshop speaker, "Role of low-level ionizing radiation in the multi-step
carcinogenic process" at the workshop on "Physical insult from and biological responses
to low-level ionizing radiation" at Brookhaven Natl. Lab., Nov. 3-4, 1994.
Invited symposium speaker, "Toxicant interference with original 'cellular phone' (gap
junctions) via perturbations of signal transduction mechanisms" at Wayne State Univ.,
Nov. 11, 1994.
Invited seminar speaker, "Reflections on the health related studies of the A-bomb
survivors of Hiroshima and Nagasaki", program in epidemiology, MSU, Nov. 17, 1994.
Invited seminar speaker, "Modulation of gap junctional communication by oncogenes,
tumor suppressor genes and tumor promoters: Implications for cancer therapy". Royal
Victoria Hospital, McGill University, Montreal, Canada, Nov. 29, 1994.
Invited seminar speaker, "Modulation of nature's original 'cellular phone' by oncogenes,
tumor suppressor genes and tumor promoters". Univ. of Indiana School of Medicine,
Dept. of Pharmacology and Toxicology, Indianapolis, Dec. 9, 1994.
Invited seminar speaker, "Oncogenes, tumor suppressor genes and modulators of
nature's original 'cellular phone': Implications for cancer causation and therapy". Ohio
State Univ. Cancer Center, Jan. 6, 1995.
Invited lecturer, "Role of cell-cell communication in carcinogenesis". Dr. J. Goodman's
Pharmaceutical/Toxicology course, MSU, Feb. 24, 1995.
Organized mini-symposium at SOT meeting, "Gap Junctional Communication for Drug
Discovery and Development", Baltimore, March 9, 1995.
Invited speaker at the EPRI symposium on "Electromagnetic Field Effects", Santa
Barbara, California, March 19-22, 1995.
Invited speaker at the Atomic Energy Control Board of Canada symposium on "Molecular
Biology and Radiation Protection", Ottawa, Canada, April 25, 1995.
Invited lecturer to Psychology Residents, MSU, "From DNA to Behavior: Role of cell
communication in reflective and behavioral disorders", May 9, 1995.
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459.
460.
461.
462.
463.
Invited symposium speaker, "The role of modulated gap junctional communication in
human toxicological risk assessment". Mich. Branch SOT, Ann Arbor, Michigan, May 19,
1995.
Invited symposium speaker at the US Air Force OSR, "Oxidative stress, gap junctional
communication and epigenetic toxicology", Fairborn, Ohio, May 30-June 1, 1995.
Invited symposium speaker at the 17th Bioelectromagnetic Society Meeting, "Laser
assisted image analyses of potential molecular, biochemical and cellular effects of EMF",
Boston, June 18-22, 1995.
Invited lecturer to MSU Medical Oncology Residency Group, "New strategies for chemoprevention and chemotherapy", MSU Medical School, Dept. of Medicine, Sept. 8, 1995.
Invited seminar speaker, "Tapping into nature's cellular phone, the gap junction, might
be the 'rosetta stone' for understanding many diseases", Dept. of Pharmacology/
Toxicology, MSU, Sept. 12, 1995.
Invited symposium speaker, "Nature's cellular phone and chemoprevention and therapy:
Communication between oncogenes and tumor suppressor genes". McLaren Regional
Medical Center, Flint, Michigan, Sept. 13, 1995.
Invited seminar speaker, "Is gap junctional intercellular communication the 'biological
rosetta stone' in the understanding of carcinogenesis". Dept. of Radiat. Oncology,
University of Michigan, Sept. 22, 1995.
Invited symposium speaker, "Radiation, signal transduction and modulation of
intercellular communication. Commemorating 50 years of Research: Hiroshima and
Nagasaki Atomic bomb survivors and their children". Houston, Texas, Oct. 7-10, 1995.
Invited symposium speaker, "Can low-level radiation 'cause' cancer?" American Nuclear
Society, San Francisco, Oct. 29-Nov. 2, 1995.
Invited seminar speaker, "Is gap junctional communication the 'biological rosetta stone'
for the understanding of chronic diseases?" Physiology Dept., MSU, Nov. 9, 1995.
Invited speaker, "Complex issues of risk assessment/management of toxic chemicals:
Science/technology/transcience". Environmental Engineering Group, MSU, Nov. 7, 1995.
Invited seminar speaker, "Is gap junctional intercellular communication the 'rosetta
stone' in the understanding of carcinogenesis and other chronic diseases?" Toxicology
Program, University of Michigan, Ann Arbor, Nov. 10, 1995.
Invited seminar speaker, "Is gap junctional intercellular communication the 'Biological
Rosetta Stone' in the understanding of carcinogenesis?" Institute for Environmental
Medicine, New York University, Dec. 6, 1995.
Invited lecturer, "The role of radiation in the multistage carcinogenic process". National
Institute of Radiological Sciences, Chiba, Japan, Jan. 29, 1996.
Invited lecturer, "Role of tumor promoters, oncogenes, and tumor suppressor genes on
the modulation of gap junctional intercellular communication: An integrative theory of
carcinogenesis". Kyoto Prefectural Medical School, Kyoto, Japan, Jan. 30, 1996.
Invited lecturer, "Modulation of cell-cell communication by carcinogens, oncogenes,
tumor suppressor genes as an integrative theory of carcinogenesis". Kyoto University,
Dept. of Radiation Genetics, Jan. 31, 1996.
Invited lecturer, "Oxidative stress, signal transduction and cell-cell communication".
Central Institute of Electric Power Research, Tokyo, Japan, Feb. 1, 1996.
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470.
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473.
474.
475.
476.
477.
478.
479.
480.
481.
Invited lecturer, "The role of oxidative stress and signal transduction in the modulation
of cell-cell communication during carcinogenesis". National Institute of Environmental
Health Sciences, Tokyo, Feb. 2, 1996.
Invited lecturer, "The discovery of the 'Biological Rosetta Stone': The role of cell-cell
communication in carcinogenesis". Seoul National University, College of Veterinary
Medicine, Seoul, Korea, Feb. 12, 1996.
Invited lecturer, "The use of cell-cell communication as a biomarker for chemical safety
and toxicity evaluations". Korea Institute of Advanced Science and Technology, Taejon,
Korea, Feb. 13, 1996.
Invited lecturer, "The use of cell-cell communication as an endpoint for drug
development and drug safety evaluation". National Institute for Safety Research, Seoul,
Korea, Feb. 15, 1996.
Invited lecturer, "The role of chemical, oncogene and tumor suppressor gene modulation
of cell-cell communication: An integrative theory of carcinogenesis". Seoul National
University School of Medicine, Feb. 15, 1996.
Invited symposium speaker, "Oxidative stress, signal transduction and intercellular
communication in carcinogenesis". Biological Effects of Radiation Injury Symposium,
Minsk, Belarus, March 22, 1996.
Invited lecturer, "Use of laser imaging to study mechanisms of carcinogenesis".
Pathology 891, MSU, April 8, 1996.
Invited lecturer, "Concepts in carcinogenesis". MSU Medical School, April 11, 1996.
Invited lecturer, "Role of intercellular communication in carcinogenesis". Pharmacology
814, April 12, 1996.
Invited lecturer, "A discovery of a 'Biological Rosetta Stone': Its implications to the
cause and prevention/treatment of human diseases".
Centennial Anniversary
Symposium of Sparrow Hospital, Lansing, Michigan, April 14, 1996.
Invited lecturer, "Current studies on the health effects of the A-bomb survivors". MSURetiree's Colloquium, Aug. 6, 1996.
Invited lecturer, "Concepts in human carcinogenesis". College of Human Medicine, Oct.
15, 1996.
Invited demonstrator, "How normal cells communicate and what happens when they
don't". Science Day, MSU, Oct. 19, 1996.
Invited lecturer, "Is gap junctional communication the ‘Biological Rosetta Stone' in the
understanding of carcinogenesis?" Food Science 807, Advanced Food Toxicology, MSU,
Oct. 24, 1996.
Invited seminar, "Role of modulated gap junctional intercellular communication in
cardiac physiology/pathology". Dept. of Medicine, MSU, Nov. 27, 1996.
Invited lecturer, “Is gap junctional communication the ‘Biological Rosetta Stone’ in the
understanding of carcinogenesis?” Advanced General Pathology (PTH 851), Nov. 4,
1996.
Invited lecturer, “How a scientist views the nature of science”. Introduction to science
studies by Dr. Alice Dreger, Lyman Briggs College, MSU, Dec. 2, 1996.
Invited speaker, “New ways of teaching chemistry: How cells talk to each other via
chemicals and what happens when they don’t”. MSU-Lansing High School Teachers
Group, Jan. 7, 1997.
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486.
487.
488.
489.
490.
491.
492.
493.
494.
495.
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497.
Invited Distinguished Alumnus Seminar at Central Michigan University, “‘The Biological
Rosetta Stone’ in the understanding of human diseases”. Central Michigan University,
Mt. Pleasant, MI, Jan. 23, 1997.
Invited lecturer, “Role of cell-cell communication in normal and abnormal cell
proliferation and differentiation”. Dr. J. Goodman, Concepts in Tumorigenesis, PHM 815,
Jan. 24, 1997.
Invited lecturer, “Is gap junctional intercellular communication the ‘Biological Rosetta
Stone’ in the understanding of proliferation and differentiation?” Molec. & Cellular
Aspects of Development, ZOL 888, Jan. 28, 1997.
Invited Grand Rounds, “The Human Genome Project, childhood cancer and the nature of
diseases”. Sparrow Hospital, Jan. 30, 1997.
Invited seminar speaker, “An update of the studies of the effects of Atomic bomb
radiation on the Hiroshima/Nagasaki survivors”. MSU International Center, Feb. 6, 1997.
Invited seminar speaker, “The role of gap junctional intercellular communication in an
integrative theory of carcinogenesis”. Karolinska Institute, Stockholm, Sweden, June 5,
1997.
Invited seminar speaker, “The toxicological and pharmacological implications of
modulated intercellular communication”. Astra Pharmaceutical, Södertälje, Sweden,
June 6, 1997.
Invited symposium speaker, “Can non-ionizing radiation ‘cause’ cancer?” Symposium on
“Mobile Phones--Is there a health risk?” Brussels, Belgium, Sept. 17, 1997.
Invited seminar speaker, “An integrative theory of carcinogenesis: Stem cells,
oncogenes, signal transduction, and modulated cell-cell communication”. Univ. of Tokyo
Medical School, Tokyo, Japan, Oct. 6, 1997.
Invited seminar speaker, “An integrative theory of carcinogenesis: Stem cells,
oncogenes, signal transduction, and modulated cell-cell communication”. Natl. Inst. of
Health Sciences, Tokyo, Japan, Oct. 7, 1997.
Invited seminar speaker, “Signal transduction, and modulated cell-cell communication”,
Natl. Inst. Radiological Sciences, Chiba, Japan, Oct. 9, 1997.
Invited workshop speaker, “Significance of cellular and intercellular processes”. Health
Effects of Low-Level Exposures: Scientific Developments and Perspectives for Risk
Assessment. Utrecht, Netherlands, Oct. 19-20, 1997.
Invited “Spartan Speaker”, “Cancer schizophrenia: The results of nature’s cellular
phones going bad”. Siena Heights College, Oct. 29, 1997.
Invited seminar speaker, “Modulation of cell-cell communication by oncogenes, tumor
suppressor genes and epigenetic chemicals: The discovery of a Biological Rosetta
Stone”. Univ. of Kansas Medical Center, Kansas City, Nov. 4, 1997.
Invited seminar speaker, “A Biological Rosetta Stone in the understanding of multiple
human diseases: Genetic and environmental disruption of gap junctional intercellular
communication”. Universita degli Studi di Palermo, Istituto di Oncologia, Palermo, Italy,
Nov. 25, 1997.
Invited symposium speaker, “Modulation of gap junctional communication during
carcinogenesis by tumor promoters, growth factors and oncogenes: An integrated
theory of carcinogenesis”. Symposium on “La Ricerca di Base nel cancro della Prostata”.
Bologna, Italy, Nov. 26, 1997.
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505.
506.
507.
508.
509.
510.
511.
512.
Invited seminar speaker, “Modulations of gap junctional intercellular communication
during carcinogenesis by tumor promoters, growth factors and oncogenes: An
integrated theory of carcinogenesis”. Istituto di Mutagenese e Differenziamente, Pisa,
Italy, Dec. 1, 1997.
Invited seminar speaker, “Oncogenes, tumor suppressor genes and intercellular
communication in the ‘oncogeny as partially-blocked ontogeny’ theory”. Ontario Cancer
Institute/Princess Margaret Hospital, Toronto, Canada, Dec. 18, 1997.
Invited seminar speaker, “Is the understanding of the role of gap junctional intercellular
communication the ‘Biological Rosetta Stone’ in the understanding of carcinogenesis?”
York University, Dept. of Biology, Toronto, Canada, Dec. 19, 1997.
Invited “Spartan Speaker”, “Discovery of a Biological Rosetta Stone: Cancer as a
schizophrenia cell”. Ferris State University, Big Rapids, MI, Feb. 6, 1998.
Plenary speaker, SOT workshop, “Modulation of gap junctional communication, disrupted
homeostasis and epigenetic toxicology”, Soc. Toxicol. Mtg., Seattle, Washington, March
1-5, 1998.
Invited seminar speaker, “Environmental toxicants, oxidative stress-induced signal
transduction and modulated cell-cell communication”, Pharmacology/Toxicology
Program, Western Ontario Univ., Canada, March 26, 1998.
Invited seminar speaker, “Is gap junctional intercellular communication the ‘Biological
Rosetta Stone’ in the understanding of the ‘Oncogeny as partially blocked ontogeny’
theory of cancer”, Cell Biology Dept., Western Ontario Univ., Canada, March 27, 1998.
Invited lecturer, “Science challenges religious world views: Implications for a Global
Bioethic”. Dr. Alice Dreger’s Faith & Reason in western Science class, MSU, April 15,
1998.
Invited lecturer, “Recent cancer ‘cures’: Hype or hope”. American Cancer Society Board
meeting, Lansing, Michigan, May 27, 1998.
Invited symposium speaker, “From radiation-induced cancers to cloning human cells to
cure disease: An unpredicted odyssey”. Michigan State University Biomedical Research
Symposium, June 1, 1998.
Invited lecturer, “Genetics and environmental influences on cancer: Insights to
prevention and treatment”. Grand Rapids Chapter of American Cancer Society, June 1,
1998.
Invited symposium speaker, “Isolation and characterization of human epithelial stem
cells”. Hiroshima Prefecteral Institute of Industrial Science and Technology”, Higashi,
Hiroshima, Japan, June 15, 1998.
Invited symposium speaker, “Mechanism of tumor promotion: Chemical carcinogeninduced oxidative stress, signal transduction and modulated cell-cell communication”.
Japanese Society of Toxicology, Nagoya, Japan, June 18, 1998.
Invited symposium speaker, “Epigenetic toxicology as toxicant induced changes in
intracellular signalling leading to altered gap junctional communication”. International
Congress of Toxicology (ICT VIII), Paris, France, July 6, 1998.
Invited seminar speaker, “Modulated intercellular communication by chemicals and
oncogenes: The mechanism of epigenetic toxicology”. L’Oréal Corp., Paris, France, July
7, 1998.
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516.
517.
518.
519.
520.
521.
522.
523.
524.
525.
526.
527.
528.
Invited symposium speaker, “Modulation of gap junctional communication by
oncogenes, tumor suppressor genes and epigenetic chemicals: The discovery of a
“Biological Rosetta Stone’”. Unite Mixte de Recherche, CNRS, Poiters, France, July 9,
1998.
Invited seminar speaker, “Role of oncogenes, tumor suppressor genes and tumor
promoters on the modulation of cell-cell communication: The discovery of a “Biological
Rosetta Stone’”. Karmanos Cancer Institute, Wayne State University, October 2, 1998.
Invited seminar speaker, “Human pancreatic stem cells in development, cancer and
diabetes”. Karmanos Cancer Institute, Wayne State University, October 2, 1998.
Invited plenary speaker, “Discovery of a Biological Rosetta Stone in the understanding
of the cause and treatment of cancer: The role of human stem cells and cell-cell
communication”. Progetto Amazzone, Palermo, Italy, Nov. 30-Dec. 4, 1998.
Invited seminar speaker, “Discovery of a Biological Rosetta Stone in the understanding
of the cause and treatment of cancer: The role of human stem cells and cell-cell
communication”. Medical Technology Program, Michigan State University, January 21,
1999.
Invited lecturer, “Genetic and environmental factors in human carcinogenesis”.
Lansing, Michigan, Jan. 13, 1999.
Invited lecturer, “Role of modulated cell-cell communication in human carcinogenesis”.
Medical Technology seminar, Jan. 14, 1999.
Invited lecturer, “Mechanism of tumor promotion: Role of chemical and oncogene
inhibition of cell-cell communication”. Jan. 29, 1999.
Invited Grand Rounds speaker, “Ethical and scientific implications of cloning human
stem cells”. Sparrow Hospital, Feb. 4, 1999.
Invited seminar speaker, “The discovery of a ‘Biological Rosetta Stone’: Role of cellcell communication in health and disease”. York University, Toronto, Canada, Feb. 28March 1, 1999.
Invited seminar speaker, “Ethical, scientific implications of cloning human stem cells”.
Biochemistry Dept., MSU, April 7, 1999.
Invited seminar speaker, “An integrative hypothesis of carcinogenesis: Role of cell-cell
communication”. Univ. of Illinois, Urbana, Illinois, April 16, 1999.
Invited symposium speaker, “Modulation of cell-cell communication in the cause and
prevention of cancer”. International conference on Diet and Prevention of Cancer,
Tampere, Finland, May 28-June 2, 1999.
Invited symposium speaker, “Human health consequences of environmentallymodulated altered gene expression: Epigenetic versus mutagenesis mechanisms of
disease”. BEMS meeting, Long Beach, California, June 22-24, 1999.
Invited symposium speaker, “The discovery of a ‘Biological Rosetta Stone’: Its
implications for radiation and chemical-induced carcinogenesis”. 11th International
Congress of Radiation Research, Dublin, Ireland, July 17-23, 1999.
Invited symposium speaker, “Role of stem cells and gap junctional communication in
human carcinogenesis”. 2nd International Congress on Human In Vitro Transformation,
Cork, Ireland, July 24-26, 1999.
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533.
534.
535.
536.
537.
538.
539.
540.
541.
542.
543.
544.
Invited symposium speaker, “Cloning of human stem cells: Scientific, therapeutic,
philosophical and ethical issues”. American Fed. Medical Res., Chicago, Illinois, Sept.
17, 1999.
Invited symposium speaker, “Modulation of differentiation by transfected dominantnegative connexin 43 in mouse osteoblast cell clones”. International Gap Junction
Conference, Gwatt, Switzerland, August 28-Sept. 2, 1999.
Invited symposium speaker, “Epigenetic toxicology:
A unifying paradigm with
mechanistic and risk assessment implications”. Epigenetic Toxicant-Induced Signal
Transduction and Altered Cell-Cell Communication Symposium, University of Michigan,
Ann Arbor, Michigan, October 17-20, 1999.
Invited symposium speaker, “Up-regulation of cell-cell communication in the
chemoprevention/chemotherapy of cancer cells”. The Fourth Princess Chulabhorn
International Science Congress, Chemicals in the 21st Century, Bangkok, Thailand,
November 28-December 2, 1999.
Invited symposium speaker, “Modulation of cell-cell communication for a strategy of
chemoprevention and chemotherapy of cancer”. International Congress on Food
Factors, Kyoto, Japan, Dec. 13-17, 1999.
Invited Grand Rounds, Sparrow Hospital, Jan. 27, 2000.
SOT meeting, Philadelphia, Pennsylvania, March 19-23, 2000.
International Conference on “Arctic Development, Pollution and Biomarkers of Human
Health”, Anchorage, Alaska, May 1-3, 2000.
Invited lecturer, “Genes, diet and environmental factors influencing cancer:
Interference with nature’s cellular phone”. Barbara Story Memorial Lectureship, May
18, 2000.
Invited seminar speaker, “Epigenetic-toxicant induced modulated gap junctional
intercellular communication:
Implications for the cause and prevention of
acute/chronic disease”. University of Miami School of Medicine, July 28, 2000.
Invited seminar speaker, “Mechanisms of up-regulated gap junctional intercellular
communication during chemoprevention and chemotherapy”, Intl. Conference on
Mechanisms of Antimutagenesis & Anticarcinogenesis, Grand Rapids, MI, Sept. 23-27,
2000.
Invited lecturer, “Cultural influences on the practice of science in Japan”. Japan and
the People, MSU, October 3, 2000.
Panel Discussion, “Doing science in postwar Japan”. Japan Week, MSU, November 1,
2000.
Invited Special lecture, “Role of stem cells and modulated gap junction intercellular
communication in the aging and carcinogenic processes”. Symposium on Aging and
Carcinogenesis, Nagasaki, Japan, November 14-15, 2000.
Invited lecturer, “Modulation of gap junctional intercellular communication:
Physiological and pathological implications for cardiovascular and other tissues”.
Cardiovascular Seminar 2000, Department of Medicine, MSU, November 20, 2000.
Invited lecturer, “Cloning of human epithelial stem cells: Their use in studying
mechanisms of normal development and therapeutic applications”. American College
of Veterinary Pathologists 2000 Annual Meeting, December 2-6, 2000., Fort Myers, Fl.
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549.
550.
551.
552.
553.
554.
555.
556.
557.
558.
559.
560.
561.
Invited Grand Rounds speaker, “Update on pancreatic stem cells:
Potential
implications towards understanding diabetes and pancreatic cancer”.
Sparrow
Hospital, Feb. 1, 2001.
Invited lecturer, “Cloning of human pluripotent stem cells for tissue bioengineering”.
EGR291, Michigan State University, March 1, 2001.
Invited lecturer, “Some philosophical and scientific issues related to human stem cell
cloning”. Michigan Society for Clinical Laboratory Science, April 18, 2001.
Invited lecturer’ ,“ Scientific and ethical implications of cloning human stem cells” ,
MSU Bioengineering Club, April 19th, 2001. Engineering Bldg,
Invited speaker, “ New Directions for human stem cell research:
Chemoprevention/Tissue replacement/ Toxicity applications”. , Estee Lauder Company,
Melville, New York, June 7th, 2001.
Invited speaker, “ Evidence for a human pancreatic cell line ( HPDE-7) as a pluripotent stem cell”., BetaGene, Inc, Dallas, Tx., June 11th, 2001.
Invited speaker, “ Human Stem cells: Philosophical, Ethical, Scientific and Medical
Implications”, Exchange Club, Lansing, Michigan, August 6, 2001.
Invited symposium speaker, “ Isolation and characterization of normal human
epithelial pluripotent stem cells”. Stem Cell Differentiation , genetic reprogramming
and Programmed cell Death”. Santorini, Greece, Sept. 2-7, 2001.
Invited symposium speaker, “Scientific Concepts of Human Nature: and Their
Implications to the Bioethics in a Scientific and technologically-Altered World” , Mali
Losinj, Croatia, Sept. Sept. 24-Oct. 1, 2001.
Invited speaker, American Cancer Society “ Making strides against breast cancer”.
Lansing, Oct. 13, 2001.
Invited symposium speaker, “Dietary modulation of gap junction communication, an
epigenetic
mechanism,
during
the
rate-limiting
step
of
the
initiation/promotion/progression process of carcinogenesis”.
8th International
Conference on Environmental Mutagens, Shizuoka, Japan, Oct. 21-26, 2001.
Invited lecturer, “ “ Discovery of a ‘ Biological Rosetta Stone’: The role cell-cell
communication in chronic diseases”. Nara Medical School, Nara, Japan, Oct. 31, 2001.
Invited lecturer, “ Dietary modulation of cell-cell communication and their effects on
the cause and prevention of human diseases”. Kyoto Prefectural University, Kyoto,
Japan, Nov. 2, 2001.
Invited seminar speaker, “ “ Isolation and characterization of adult human stem cells:
Implications to understanding carcinogenesis and for tissue replacement”. Radiation
Effects Research Foundation, Hiroshima, Japan, Nov. 5, 2001.
Invited lecturer, “ Scientific concepts of human nature and the ‘Bioethical’ implications
scientific and technological interventions”. Tokuyama University, Fukuoka, Japan, Nov.
6, 2001.
Invited seminar speaker, “ Discovery of a ‘Biological Rosetta Stone’: Its implications to
the cause and prevention/treatment of human diseases, such as birth defects, cancer,
atherosclerosis, and diabetes”. Nagasaki University, Nagasaki, Japan, Nov. 8. 2001.
Invited symposium speaker, “ Role of human stem cells in understanding human aging
and the diseases of aging”. International Conference on Low Level Radiation Risks”.
Kagashima, Japan, Nov. 9., 2001.
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575.
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Invited symposium speaker, “The role of human stem cells in the aging and the diseases
of aging”. Okinawa International Conference on Longevity, Nago, Okinawa, Nov. 12-13,
2001.
Invited seminar speaker, “The Discovery of a ‘Biological Rosetta Stone’ and its
implications to the understanding of the multi-staged carcinogenic process”. Kanazawa
Universityu, Kanazawa, Japan, Nov. 15, 2001.
Invited seminar speaker, “Isolation of adult human stem cells and their implications to
the understanding of various human diseases and to the replacement of diseased
tissue”. Kihara Institute for Biological Research, Yokohama, Japan, Nov. 19, 2001.
Invited seminar speaker, “The ‘Biological Rosetta Stone’ and its implication to the stem
cell theory of cancer”.: New Strategies for the prevention/treatment of cancer”.
Kanagawa Cancer Center, Tokyo, Japan, Nov. 19, 2001.
Invited seminar speaker, “Modulation of human cancer by dietary factors interfering with
cell-cell communication”. Tokai University School of Medicine, Bohseidai, Isehara,
Kanagawa, Japan, Nov. 20, 2001.
Invited seminar speaker, “Stem cell theory of carcinogenesis: Implications for the cause
and treatment of cancer”. National Institute of Health Sciences, Tokyo, Japan, Nov. 21,
2001.
Invited seminar speaker, “The role of stem cells in carcinogenesis: Role of dietary
factors, altered cell communication in the cause and prevention of carcinogenesis”.
National Cancer Center Research Institute, Tokyo, Japan, Nov. 22, 2001.
Invited seminar speaker, “Isolation of adult human stem cells and their use in studying
gene expression in differentiation”. National Institute of Radiological Sciences, Chiba,
Japan, Nov. 22, 2001.
Invited speaker, “What are the philosophical/ethical and medical implications of “cloning”
human stem cells.”, Mason Rotary Club, Jan. 3, 2002.
Invited Symposium speaker, “Cell-Cell Communication and Epigenetic Instability”,
Internatl. Symposium on Radiation induced genetical instability”, Nagasaki University,
Japan, Feb. 22-23, 2002.
Invited speaker, “ Ethic issues of human reproductive and regenerative clone of stem
cells. Dr. Price-Foley, Detroit College of Law at MSU, Feb. 27th, 2002.
Invited seminar speaker, Stem cells and cell-cell communication as ‘Biological Rosetta
Stones’ in the understanding of the cause and prevention of cancer”. Institute of
Environmental Medicine, University of Pennsylvania Medical School, Philadelphia, March
1, 2002.
Invited lecturer, “ Human cloning: So why is it unethical?”. Owen Graduate Center,
March 19, 2002.
Invited course lecturer, Scientific, medical and philosophical implication of clonal of
human stem cells for reproducing humans or therapy.” `Biology Dept., Central Michigan
University, Mt. Pleasant, Michigan, April 10, 2002.
Invited lecturer, “ Human cloning: Is it the descent of angels or the ascent of man?. Lay
lecture, Central Michigan University, Mt. Pleasant, Michigan, April 10, 2002.
Invited seminar speaker, “ Role of stem cells and cell-cell-communication in human
carcinogenesis”. Dept. Biochemistry and Molecular Biology, University of Miami School of
Medicine, April. 12, 2002.
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Invited speaker, “ “ Human cloning: Is it the descent of angels or the ascent of man?”
Tri-Annual Southern Michigan Cytogenetics Conference, East Lansing, Michigan, April 16,
2002.
Invited lecturer, “ Role of Dietary Influences in Human Carcinogenesis”. Advanced Food
Toxicology- FSC 857, Sept. 3, 2002.
Invited symposium speaker, “ Molecular mechanisms of cellular toxicity of environmental
toxicants implicated in Balkan Endemic Nephropathy”. International Conference on
Balkan Endemic Nephropathy at Michigan State University, Sept. 30, 2002.
Invited Medical School Lecturer, “ Concepts of Human Carcinogenesis”. MSU, East
Lansing, Mi., Oct. 17, 2002.
Invited lecturer, “ Stem cells and Cell- Cell Communication in Carcinogenesis”, Advanced
General Pathology- Pth 851; MSU. Oct. 23, 24, 2002.
Invited lecturer, “Human Cloning: Myths and Potentials”. Okemos Kiwanas Culb, Jan. 15,
2003.
Invited lecture: Concepts of Carcinogenesis: Implications for Epidemiological Studies”.
Cancer Epidemiology –EPI 823, Dr. Ellen Velie, Jan. 21, 2003.
Seminar: The role of modulated gap junctional intercellular communication in
maintaining cellular homeostasis and in various human diseases”. Pharmaceutical
testing Group at the Hatano Research Institute, Tokyo Feb. 18, 2003.
Seminar: “Isolating Adult Human Stem Cells and Their Use in
Treating Various
Human Diseases by their use in screening for potential Chemopreventive agents.2003,
The Nutrition Science Department, Kyoto Prefectural University, Kyoto, Japan:
Nagasaki, Japan. Feb. 18th, 2003.
Invited Plenary Speaker, “ Hallmarks in Radiation Carcinogenesis: Ignored Concepts”.
First Nagasaki Symposium of International Consortium for Medical Care of Hibasusha
and Radiation Life Sciences”. Nagasaki, Japan, Feb. 21-22, 2003.
Invited speaker: ““Research Challenge for Low Level Acute and Chronic Radiation
Exposure”]. At the Strategic Meeting for the New Center for Excellence “.] I was asked
to provide the Summary of the meeting lecture [Nagasaki, Japan, Feb. 23, 2003.
Continuing Education Lecture at the Society of Toxicology Meetings in Salt Lake City,:
“ Overview of the interplay between genetics and Epigenetic Abnormalities in Cancer”,
March. 9, 2003.
Invited symposium speaker. “ Use of adult human pluripotent stem cells to screen for
genotoxic/epigenetic toxicants”. Society of Toxicology meeting, Salt Lake City, March
11, 2003.
Invited symposium speaker: “Epigenetic toxicant –induced modulation of Cell-cell
communication/pesticides/risk assessment: Different mechanisms but all roads lead to
Rome”. International Symposium to Honor Dr. Robert Hollingworth, Amer. Chemical
Soc. New Orleans, March 24, 2003.
Invited symposium speaker, “ Human stem cells as the target for the aging and the
diseases of aging”. Dept. Pediatrics and Human Development Research Day, May 30,
2003, MSU, East Lansing.
Invited symposium speaker, “ Stem cells, cell-cell communication and epigenetic
toxicants: Risk assessment implications”. 2003 Congress on In Vitro Biology, Portland,
Oregon, June 2, 2003.
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Invited lecturer at the McGregor Colloquim, “ Human stem cell research: Is this the
beginning of the Ascent of Man or the Descent of Angels?”, Alma College, Alma,
Michigan, Aug. 18, 2003.
Invited speaker, American Cancer Society meeting, Kellogg Center, MSU, Lansing,
Michigan, August 21, 2003.
Invited speaker, “Human adult stem cells and cell-cell communication in the aging and
diseases of aging processes”. Genetics Program, Michigan State University, August 26,
2003.
Invited speaker “ The role of stem cells and cell-cell communication in cancer
chemoprevention strategies”.
ICMAA-VII, 8Th
International conference on
mechanisms of anti-mutagenesis and anticarcinogenesis. Pisa, Italy, Oct. 4-8, 2003.
Invited Plenary Speaker, “ Ignored hallmarks of carcinogenesis: Stem cells and cell-cell
communication” , International Course on “ Signal Transduction and communication in
cancer cells”. Erice, Sicily, Oct. 24-31, 2003.
Invited speaker “ Role of stem cells and cell-cell communication in radiation
carcinogenesis: Ignored concepts”. Adv. Workshop on “ Radiation-induced multi-organ
involvement and failure: A challenge for pathogenic, diagnostic and therapeutic
approaches and research”. Schloss Reisenburg, Ulm, Germany. Nov. 12-15, 2003.
Invited lecturer, “What the Ancient Chinese and My Grandmother Knew About Eating
for Health…You Don’t Need a Ph.D.!” HM Food Safety and Human Health, Mich. State
University, Jan. 29, 2004.
Invited Plenary Speaker, “7th International Symposium on Predictive Oncology and
Intervention Strategies” Nice, France. February 7-11, 2004.
Invited Speaker: Low dose induction of differential signaling modulating epigenetic
responses in stem, progenitor and terminally-differentiated cells via intercellulae
communication.” Munich, German, February 14-18, 2004.
Invited seminar speaker, “ Oct-4 expression and lack of cell-cell communication as
“’hallmarks” of carcinogenesis: New evidence for the stem cell theory of cancer”.
Genetics Program, MSU, May 3, 2004.
Invited symposium speaker, “ Epigenetic toxicant-induced modulation of cell-cell
communication and risk assessment of microbial toxins. 18th Annual Brunner Protein
symposium, Kellogg Center, Lansing, Michigan, May 21, 2004.
Invited J.E. Trosko “Crises in the chemical genotoxicity paradigm: Stem cells, cell-cell
communication and systems biology as ignored concepts”. 10th International Congress
of Toxicology, Tampere, Finland, July 11-15, 2004.
Invited Plenary Speaker, J.E., Trosko, “Use of human adult stem cells to screen for
genotoxic/epigenetic toxins and toxicants”. 5th Princess Chulabhorn International
Science Congress, “ Evolving Genetics and Its Global Impact”. Bangkok, Thailand, Aug.
16-20th, 2004.
Invited seminar speaker, J.E. Trosko, “Ignored Hallmarks of Cancer: Roles of Adult
Stem Cells and Cell-Cell Communication in Human Carcinogenesis.
Invited Plenary Speaker, J.E. Trosko, “Role of human adult stem cells and cell-cell
communication in the cause, prevention and treatment of cancer”, Oriental Medicine
and Life Sciences”. Seoul, Korea, August 28th, 2004.
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Invited speaker, J.E. Trosko, “A new theory of aging and the diseases of aging: Can
we separate the ‘dancer from the dance’?”, Lunch and Learn Club, MSU Faculty Club,
Sept. 14, 2004.
Invited lecturer, J.E. Trosko, “ The Bioethics of human stem cell research:
Philosophilical, scientific, medical and bioethical implications.” MSU Bioethics Club, Oct.
6, 2004.
Invited plenary speaker, J.E. Trosko, “ The role of stem cells and gap junctions as
targets for cancer chemoprevention and chemotherapy”. 1st Annual Conference on
Organization for Oncology sand Translational Research ( OOTR), Shangri-La Island,
Hong Kong, Oct. 15-16, 2004.
Invited speaker, J.E. Trosko,
“ The role of stem cells and gap junctional
communication in carcinogenesis”. 1St Satellite Conference of the OORT Institution,
Sun Yat Sen Memorial Hospital, Guangzhou, China, Oct. 17th, 2004.
Invited lecturer, J.E. Trosko, “ Biology of human carcinogenesis for Epidemiologists:
Concepts needed for the understanding of etiology, prevention and treatment of
cancer”. Cancer Epidemiology EPI 823, Dr. Ellen Velie, MSU, January 25th, 2005.
Invited seminar speaker, J.E. Trosko, “ The role of adult human stem cells and cellcommunication in carcinogenesis”. Natl. Institute Health sciences, Tokyo, Japan, April
6th, 2005
Invited seminar speaker, J.E. Trosko, “ Role of low level radiation on adult human
stem cells and cell-cell communication in human cancer”. Radiation Effects Research
foundation ( RERF), Hiroshima, Japan, April 11, 2005.
Invited seminar speaker, J.E. Trosko, “ Biomarkers for adult human breast epithelial
stem cells and their potential use in radiation-induced breast cancer risk assessment”.
Radiation Effects Research Foundation- Radiology Division, Hiroshima, Japan, April 12,
2005.
Invited seminar speaker, “ Use of Adult human stem cells and cell-cell communications
as biomarkers to screen for cancer chemopreventive/chemotherapeutic agents”. Kyoto
Prefectual University, Kyoto, Japan, April 17th, 2005.
Invited seminar speaker, “ Does low level radiation exposure really induce DNA
damage, mutations and initiate cancer?”. Kyoto University Reactor Institute in
Kumatori, Japan, April 19th, 2005.
Invited lecturer, J.E. Trosko, “ The roles of adult stem cells and cell-cell
communication in low level radiation bystander effects and adaptive responses”.
University of Nagasaki Department of Pharcology and Division of Radiobiology,
Nagasaki, Japan, April 21, 2005.
Invited symposium speaker, J.E. Trosko, “ Implications of human stem cells and cellcell communication in cancer chemoprevention and chemotherapy”. University of
Nagasaki School of Medicine, Nagasaki, Japan, April 22, 2005.
Invited seminar spearker, J.E. Trosko,” Identification of biomarkers for adult human
stem cells, pre-malignant and malignant cancer cells”: implications for
chemoprevention and chemotherapy”. Nihon University School of Medicine, Tokyo,
Japan, April, 25th, 2005.
Invited high school discussant, J.E. Trosko, “ Factors influencing a choice in science as a
career”. MSU-Upward Bound students. May, 10th, 2005.
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Invited high school lecturer, J.E. Trosko, “ Implications of isolating human stem cells”.
Holt High School, Holt, Michigan , May 18th, 2005.
Invited symposium speaker, J.E. Trosko, “ Adult stem cell theory of the multi-stage,
multi-mechanism model of carcinogenesis: Role of inflammation on the promotion of
initiated stem cells”. Environmental Mutagen Society Meeting, San Francisco, Sept. 4-6,
2005.
Invited lecturer, J.E. Trosko, “ Oct-4 gene expression and lack of cell-cell communication
as ‘Hallmarks ‘ of adult human stem cells: evidence for the stem cell theory of cancer”.
Physiology Dept. Seminar, Sept. 14th, 2005.
Invited lecturer, J.E. Trosko, “ Stem cell research- What is happening today”,
Presbryterian Church, Nov. 6th, 2005.
Invited lecture, J.E. Trosko, “ Oct-4 gene expression and the lack of cell-cell
communication as ‘hallmarks of cancer: Evidence for the stem cell theory of cancer”. In
Nutrition and Chronic Diseases” course, Michigan State University, Dr. Dale Ramsos,
Instructor.Nov. 14th, 2005.
Invited international symposium, J.E. Trosko, “ Use of adult human stem cells in
toxicology” at the meeting on “Current Trends to streamline the safety assessment of
pharmaceuticals”, Paris, France, Nov. 17-18, 2005.
Invited International symposium plenary speaker, J.E. Trosko, “The quantitative and
qualitative aspects of human adult stem cells are responsible for the aging and cancer
processes: Why didn’t Methusala ever get cancer?” , at the meeting on “ Aging, life, and
Cancer”. Erice, Sicily, Dec. 15-19th, 2005.
Invited symposium speaker, “ Oct-4 and Connexins as markers for Adult human
stem cells and the evidence that aduklt stem cells are targets for human cancers”. Seoul
Natl. University and Bio-Max/Bio-Hub Corporation, Febuary 28, 2006, Seoul, Korea
Invited symoposium speaker, “ The role of adult human stem cells as targets for
carcinogenesis: Oct-4 as a marker for ‘ Oncogeny as partially blocked ontogeny’ theory
of carcinogenesis”. GTCBIO Symposium on Stem Cells.:Research and Therapy. San
Francisco, March 2-3, 2006.
Invited Seminar speaker “ Use of Human Embryonic and and stem cells for drug
screening and safetry assessment” , British Toxicology Society, UK Environmental
Mutagen Society and British In Vitro Toxicological Society Joint Meeting, Warwick,
England, March 20, 2006.
In vited seminar speaker, “ Oct-4 gene expression and the lack of cell-cell
communication as ‘ hallmarks of cancer: Evidence for the stem cell theory of cancer”.
University of Surrey, Guildford, England, March 24, 2006.
Invited lecturer, “Influence of the Japanese physical environment on Japanese values
and behavior. IAH 231 course, March 30, 2006[ Dr. Evelyn Cudel Professor].
Invited International Symposium Speaker, “ From adult stem cells to cancer stem cells:
Oct-4 gene, cell-cell communication and hormones”. Estrogens and Hormones. Ettore
Majorana Foundation and Centre for Scientific Culture, Erice, Sicily, May 15-21, 2006.
Invited lecturer, “Oct-4 gene expression and lack of cell-cell communication as ‘
hallmarks’ of adult human stem cells: Evidence for the stem cell theory of cancer”.
Cancer Research-UK, London, May 23, 2006.
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645.
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644.
645.
646.
647.
In vited lecturer, “Good news/bad news of knowing the bases of food safety
/toxicology”. VM 810, Natl. Food Safety Toxicology Center, Michigan State University,
June 17th, 2006.
Invited seminar spearker, “Oct-4 gene expression and the lack of cell-cell
communication as ‘ hallmarkers of cancer: Evidence for the stem cell theory of cancer”.
Veterinary Research Institute, Brno, Czech Republic, June 30, 2006.
Invited symposium speaker, “Crises in the chemical genotoxicity paradigm: Stem cells,
cell-cell communication and systems biology as ignored concepts”. European
Environmental Mutagen Society Symposium, “” From genes to molecular epidemiology”,
Prague, Czech Republic, July 2-6, 2006.
Invited symposium speaker, “ Concept needed to understand potential health effects of
low level radiation: Role of adult stem cells and modulated cell-cell communication”. The
2nd Nagasaki Symposium of International Consortium for Medical Care of Hibakusha and
Radiation Life Science”, Nagasaki, Japan, July 26-28, 2006.
Invited seminar spearker, “Oct-4 gene expression and the lack of cell-cell
communication as ‘ hallmarkerrs of cancer: Evidence for the stem cell theory of cancer”.
Veterinary Research Institute, Brno, Czech Republic, June 30, 2006.
Invited symposium speaker, “Crises in the chemical genotoxicity paradigm: Stem cells,
cell-cell communication and systems biology as ignored concepts”. European
Environmental Mutagen Society Symposium, “” From genes to molecular epidemiology”,
Prague, Czech Republic, July 2-6, 2006.
Invited symposium speaker, “ Concept needed to understand potential health effects of
low level radiation: Role of adult stem cells and modulated cell-cell communication”. The
2nd Nagasaki Symposium of International Consortium for Medical Care of Hibakusha and
Radiation Life Science”, Nagasaki, Japan, July 26-28, 2006.
Invited lecturer, “Adult stem cells, Cancer Stem Cells and Markers for detection and
treatment”. Workshop on Adult Stem Cell Research, Icheon, Korea, Aug. 25-27, 2006.
Invited lecture, Asian Federation of Laboratory Animal Sciences Associations, Jeju,
Korea, Aug. 30-Sept. 1, 2006.
Invited lecturer, “New Concepts for Chemical Carcinogenesis Risk
Assessment: The Roles of Adult Stem Cells and Modulated Cell-Cell
Communication in Human Carcinogenesis”. School of Public Health, Seoul
National University. September 21st,2006 {Dr. Kyungho Choi}.
Invited lecturer, “ Adult stem cells, Cancer stem cells : Markers and New Strategies
for Prevention and Treatments”. College of Medicine, Seoul National University,
September 22nd 2006, (Dr. Noh, host).
Invited lecturer, Symposium: Stem Cell Research in Veterinary Medical Sciences,
“Status and Prospectives of Stem Cell Research”, September 27-29th Dr. KyungSun Kang. Seoul , Korea
Invited lecturer, “New Strategies for Dietary Chemoprevention & Chemotherapy for
Environmentally-Induced Cancers: Modulation of Oct-4 Gene and Cell-Cell
Communication of Adult Human ‘Cancer Stem’ Cells”. October 18th, Dr. Joonhong
Park, School of Civil and Environmental Engineering, Yonsei University. Seoul,
Korea.
Invited symposium speaker, “Oxidative stress in the modulation of Oct-4
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Expression and Cell-Cell Communication in Stem Cell Biology and During
Carcinogenesis” , Symposium: “ Redox-Sensitive Transcription Factors as Potential
Therapeutic Targets”. Dept. of Pharmacy, Seoul Natl. University, October 21st, 2006.
Dr.Youn-Joon-Suhr, host.
648. Invited lecturer, “New Strategies for Dietary Chemoprevention & Chemotherapy for
Environmentally-Induced Cancers: Modulation of Oct-4 Gene and Cell-Cell
Communication of Adult Human ‘Cancer Stem’ Cells”. Oct. 23rd. Dr. Kyung-Sun
Kang, course on Nutrition and Health in the College of Veterinary Medicine.
{ Modified for “Comparative medicine in Human and Veterinary Health”}.
649. Invited lecturer. “Role of Adult Stem Cells and Cell-Cell Communication in the
Initiation/Promotion/Progression Phases of Human Carcinogenesis”. Lecture in
Young-Joon Suhr’s course on “ Molecular Cancer Biology. College of Pharmacy,
SNU. October 31, 2006. Young-Joon Suhr.
650. Invited symposium speaker, International Conference on Toxicogenomics”, Korean
651. Invited lecturer, “ Role of adult stem cells and cell-cell communication in carcinogenesis”.
PDI 851 course, College of Veterinary Medicine, Dr. Charlesa McKenzie, Michigan State
University, Nov. 13, 2006.
652. Invited lecturer, The Hype & Hope of Human Stem Cell Research”, Lyman Briggs Science
Forum, Michigan State University, Dr. Susan DeGraw, Nov. 15th, 2006.
653. Invited Symposium speaker, “ From characterizing epigenetic toxicants,
chemopreventive/chemotherapeutic agents to stem cells and to mechanisms of cancer and
multiple chronic diseases: International Symposium on “Gap Junctions as the Biological
Rosetta Stone”. Physiological and Pathological Importance of gap junctions”. Tokyo, Japan,
Nov. 20-24, 2006.
654. Invited symposium speaker, “ Epigenetic mechanisms and risk assessment: Were chemical
genotoxicants the WMD’s of Environmental Toxicology”. Symposium on Genomic and
epigenomic determinants of toxicant Response”. Montreal, Canada, Society of Toxicology
of Canada, Dec. 4-5, 2006.
655. Invited International Symposium speaker, “‘Chemical carcinogens as mutagens’ and
“Molecular Epidemiology of cancer’ are bankrupt paradigms: Stem cells, altered cell-cell
communication and epigenetic mechanisms as ignored concepts”. UK Molecular
Epidemiology Society, Imperial College, London, England, Dec. 8th, 2006.
656. Invited lecturer, “Why has stem cell research hit a raw nerve in world politics?” Okemos
Church, Okemos, Michigan, Jan. 7th, 2007.
657. Invited lecturer, “What epidemiologists must know about the design and interpretation of
studies to determine risks to cancer induction: What are the concepts behind human
carcinogenesis?” Course on Cancer Epidemiology, Dr. Ellen Velie, Jan. 17, 2007.
658. Invited Plenary lecturer: “From characterizing epigenetic toxicants, chemopreventive,
chemotherapeutic agents to stem cells & to mechanisms of cancer and multiple chronic
human diseases: Gap junction as a ‘Biological Rosetta Stone’”. Workshop : The role of
gap junctional intercellular communication in carcinogenesis by Industrial and
Environmental Chemicals. Foggia, Italy, March 27 & 218th, 2007.
659. Invited lay lecturer: Role of diet, environment, individual behaviors and cultural factors
on cancer and chronic diseases. Castlebuono, Sicily , March, 2007.
660. Invited lecture: Gap junctional intercellular communication and its implications in cancer
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prevention and therapy”. Dept. of Pharmacology, University of Palermo, June 21, 2007.
661. Invited lecture: “ Cancer and aging: Dysfunction in the quantity and quality of adult
stem cells and intercellular communication” or “ Why Methuselah did not get cancer”.
Department of Pathology, University of Palermo, April 20, 2007.
662: Invited lecture: Role of adult stem cells in carcinogenesis. The origin of “cancer stem
cells”. Dept. of Oncology , Special Sicilian Medical Society Symposium. Dr. Bioggio
Agostura, President, May, 26, 2007.
663: Invited lecturer, “New concepts on the cause, prevention and treatment of breast
cancer or “What mom ate affected your breast stem cells” and “ What you eat affects
your breast stem cells”. Michigan State University Breast Cancer Center, October 26th,
2007.
664. Invited lecturer, “The Role of diet on the quality and quantity of human breast adult
stem cells in breast cancer.” Or “ What your mother ate while you were in utero affects
the number of your breast stem cells and what you eat affects whether your initiated
breast stem cells become cancerous”. Human Nutrition and Chronic Disease HNF840,
Wed., Food Science Human Nutrition Bldg. Nov. 7, 2007
665. Invited Internatl. Symposium Speaker, “ Environmental and dietary chemical-induced
health effects via epigenetic modulation of the quantity and quality of adult human
stem cells and cell-cell communication” The 6TH Princess Chulabhorn International
Sciencve Congress: The Interface of Chemistry and Biology in the “omics” Era” ,
Bangkok, Thailand, Nov. 25-29, 2007.
666. Invited Internatl. Symposium speaker, “ Dietary Modulation of the Quantity and Quality
of Adult Human Stem Cells, Pre- and Post- Natally, Affects the Aging and diseases of
Aging Processes.” “ La Medicina del Domani”, Taormina, Sicily, Dec. 9th, 2007.
667. Invited lecture : “ Stem Cells: Their potential role in the case, prevention and treatment
of human diseases”., MSU-Faculty Emerti Group, Jan. 23, 2008
668. Invited lecture:” Cows & Dogs cause human breast and prostate cancers: How biological
and cultural evolution impact on diet, stem cells and chronic diseases”. Dept. of Food
Science and Human Nutrition, Michigan State University, Feb. 20, 2008.
669. Invited lecture: Helen Shingleton Memorial Lecturership “Is Diet essential for Cancer
Prevention: A basic scientist’s view of epidemiology approaches” Michigan State
University, Radiology Auditorium, March 7th, 2008.
670. Invited Lecturer: “What your mother ate while you were in utero affects the number of
your breast stem cells and what you eat affects whether your initiated breast stem cells
become cancerous”. Pro-Masters Course on Food Safety, Natl. Food Safety Toxicology
Center, MSU, March 12th, 2008.
671. Invited lecturer: “Stem cells: Their potential role in the cause, prevention and treatment
of human diseases”. Edgewood Church, East Lansing, March 17th, 2008.
672. Invited lecturer: “Stem cells, the Barker hypothesis, Environment/Diet and cancer stem
cells: New insights to cancer Prevention/therapy” Breslin Cancer Center, Lansing,
Michigan, Aug. 8th, 2008.
673. Invited lecture: “Chemical modulation of gap junctional intercellular communication in
toxicology: The Rodney Dangerfield of Toxicology” ( “Gap junctions get no Respect!”).
Wash. D.C., August 28th, 2008. Interagency meeting between EPA, FDA, NIEHS, NTP,
NIOSH)
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674. Invited symposium Plenary Lecturer: “Science Issues related to the use of human
embryonic and adult stem cells for drug discovery and safety assessment”. North
American Congress of Clinical Toxicology. Toronto, Canada , Sept. 13, 2008.
675. Invited symposium lecturer: “ Pre-and Post-Natal Exposures to Epigenetic Toxicants and
Modulation of risks to Chronic Diseases”, Riva del Garda, Italy, Sept.
24th, 2008, FISV Congress.
676. Invited symposium lecture: “The State of the Art on Stem Cell Technology: To Use
Human Embryonic or Adult Stem Cells For Drug Development and Safety Assessment,
European Environmental Mutagen Society, Rhodes, Greece, Oct. 3- , 2008.
677. Invited lay lecturer, “Genes, diet, environmental and cultural factors in human cancer”.
American Cancer Society-Lansing chapter, Oct. 27, 2008.
678. Invited lecturer, “ Philosophical, ethical, scientific and medical issues of human stem
therapy”, Dr. Robt Pennock’s course, Philosopy of Technology- LB 300, Lyman Briggs
College, Oct. 29th, 2008.
679. Invited lecturer: “ Role of cell-cell communication in health and disease” Vet Pathol (PDI
851). Michigan State State University, Nov. 5th, 2008.
680. Invited symposium speaker, “The Barker hypothesis: How your mother, culture, lifestyle
and diet influence your risk to cancer”. Symposium on “Nutrigenomics: Diet and DNA”,
Dept. of Radiology, Michigan State University, Nov. 7th, 2008.
681. Invited Lecturer: The Implications of the Barker Hypothesis for chronic diseases in
children. Adults and transgenerational descendents. Sparrow Hospital ICU, Dec. 9th,
2008.
682. Invited lecturer: “on being an ‘alien’ doing scientific research in Japan, Korea, and
Sicily: The integration of the physical, biological, psychological, social/cultural factors
relation to problem solving”. INPEP ( Internatl Neurologic & Psychiatric Epidemiology
Program), Patenge Rm, Mich. State University, Jan. 13, 2009.
683. Invited lecturer: “ Complex causes of human diseases: Genes, Environment, Diet, &
Global Cultural Choices”. Global Perspectives Conference, Lansing Community College,
March 30m 2009.
684. Invited lecturer: “The Barker hypothesis: Epigenetic modulation of stem cells and cellcell communication in toxicant-induced chronic human diseases”. Pharmacology
Toxicology Department, MSU, April 15, 2009.
685. Invited symposium speaker: “The Barker hypothesis, Diet, and Stem Cells in breast
cancer: Understanding the causes of breast cancer can lead to prevention and better
treatment”. Michigan Breast and Cervical Cancer Control/WISEWOMAN Annual
meeting, Traverse City, April 24, 2009.
686. Invited lecturer: “Toxico-epigenetics: The Barker hypothesis, Environmental/Dietary
Modulation of Cell Communication, Abnormal Human Stem Cell Behavior and Chronic
Diseases”. Dept. Environmental Health Sciences, Univ. Michigan, Ann Arbor, May 6th,
2009.
687. Invited lecturer: “Dogs, Cows, and Human Prostate Cancer: How Genes, Diet, Bad
Habits and Your Mother Influence One’s Risk of Prostate Cancer” Prostate Cancer
Support Group of Mid-Michigan”, Sparrow Hospital, May 7th, 2009.
688. Invited symposium speaker: An odyssey of a basic scientist to bridge the Two
Cultures”. Science and Liberal Education: C.P. Snow and the Two cultures”, Kellogg
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Center, Michigan State University, May 28-29, 2009.
689. Invited seminar speaker, “The Barker Hypothesis: Epigenetic Modulation of Stem cells
and Cell- Cell Communication in Toxicant-Induced Chronic Human Diseases”. Center
for Environmental Health, University of Indiana School of Medicine, Indianopolis, June
3, 2009.
690. Invited Symposium speaker: “ XXXXXXXX “ Dutch Society of Toxicology, Velhoven,
Netherlands, June 16-21, 2009.
691. Invited plenary spealker: “
“, Congress on Signal Transduction and Communication
in Cancer Cells”. Salzburg, Austria, July 2-7, 2009.
692. Invited panelist: “Partnering with USEPA and ATSDR to Improve the USE of Superfund
Research Program Science”. EHS-SRB Superfund meeting, Chapel Hill, N.C., July, 2729, 2009.
693. Invited Plenary Speaker: “Cancer Prevention”. Inter-Triibal Council of Michigan Health
People conference, Traverse City, August 4-5th.
694. Invited symposium speaker:“System integration of human stem cells, epitoxicogenomics, cell-cell communication: The barker hypothesis and chronic human
diseases”. X Internatl. Conference on Environmental Mutagens-ICEM”, Firenze, Italy,
August 20-25, 2009.
695. Invited Plenary Speaker, “Introductory Welcome”, Internatl. Conference on
Environmental, Occupational & Life Style Concerns- Transdisciplinary Approach”, Sept.
14-20, Bangalore, India, Sept. 14-20th, 2009.
696. Invited Plenary Speaker, “A collision of biological and culturalal evolution: The toxicoepigenomics of environmental and dietary chemicals on stem cells and cell- cell
communication in health and diseases”. Internatl. Conference on Environmental,
Occupational & Life Style Concerns- Transdisciplinary Approach”, Sept. 14-20,
Bangalore, India, Sept. 14-20th, 2009.
697. Invited Plenary Speaker, “Epigenetic chemical effects on stem cells and cell-cell
communication and their roles in the cause and prevention of human carcinogenesis.”
Internatl. Conference on Environmental, Occupational & Life Style ConcernsTransdisciplinary Approach”, Sept. 14-20, Bangalore, India, Sept. 14-20th, 2009.
698. Invited seminar speaker, “ Concepts of Human Nature: The Clash of the Two Cultures”,
MSU-Honors College, Oct. 4, 2009.
699. Invited seminar speaker: “ Role of Human Adult Stem Cells, Cell-Cell Communication,
Nutrition/Diet on the Multi-stage, Multi-Mechanism Process of Carcinogenesis: Pre
( Barker Hypothesis)- and Post-natal Consequences”. Roswell Park Cancer Institute, Oct.
26, 2009.
700. Invited Plenary Speaker: “Are ‘iPS’ Cells the Result of the Selection of Adult Stem Cells
or the ‘Re-programming’ of Somatic Differentiated Cells?: A view from Developmental
Biology, Cancer Biology and Aging Research”. 2009 Annual Mtg. of Korean Society for
Stem Cell Research; Seoul Natl. University, Nov. 5th, 2009.
701. Invited seminar speaker: Role of Environmental and Nutritional/Dietary Factors on Adult
Human Stem cells and Cancer & Aging. Konkuk University, Seoul, Korea, Nov. 6th, 2009.
702. Invited Plenary Speaker: The Origin of Cancer- The Adult Stem Stem or Programmed
“iPS” cells: Implication of Environmental/Dietary Modulation of Resistance or Sensitivity
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to Cancer and Aging”. At the 2009 Cancer Stem Cell Symposium, Seoul Natl.
University, Nov. 9-10th, 2009.
703. Invited symposium speaker: “ Role of Human Adult Stem Cells, Cell-Cell
Communication, Nutrition/Diet on the Multi-Stafge, Multi-Mechanism Process of
Carcinogenesis: Pre (Barker Hypothesis)- and Post- Natal Consequences.” Internatl.
Symposium on Frontiers in Carcinogenesis and Cancer Prevention: Scientific Endeavors
and Public Health Initiatives”. Dhirubhai Ambani Life Science Center, Mumbi, India, Feb.
5-7, 2010.
704. Invited Symposium Speaker. “ Modulation of Human Stem Cells During in utero
Exposures to Toxicants: A Mechanistic Explanation to the Barker Hypothesis”. Soc.
Toxicology Mtg., March 15-7-11, 2010., Salt Lake City, Utah.
705.Invited Symposium speaker. “ From Radiation Biology to Chemical Carcinogenesis,
Bioethics, Toxicology , Stem Cell Biology to Aging Biology” Career Alternatives in
Toxicology: Lessons Learned. Soc. Toxicology, Salt Lake city, Utah, Marc 7-11, 2010.
704. Invited Symposium speaker. “ Toxico-Epigenetics: Modulation of Gene Expression in
Stem Cells and Cell-Cell Communication During the Totality of Human Development and
Its Link to Birth Defects, Chronic Diseases, and Aging”. Pediatrics Academic Societies
Mtg, Vancover, Ca., May 1-4th, 2010.
DEPARTMENTAL COMMITTEE AND ADMINISTRATIVE/CONSULTING SERVICES
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Co-authored two 191 laboratory exercises, "Some properties of radioactivity:
Preliminary details of equipment, company interviews, etc”.
Revised laboratory exercises, Summer 1968.
Collected electron micrographs from G. Spink for 192 laboratory manual.
Examination committee 192, 1967-1968, Summer 1968, 1968-69.
Examination committee, EU-191, EU-192, EU-193, 1968-69, also graded essay exam for
track, Fall, Winter.
One of the originators of the EU-191, EU-192, EU-193 tracks.
All University Graduate Committee, 1968.
Designed upper-tier course to meet College of Engineering requirements and University
College goals . . . "Science and Human Values".
Designed upper classman course in Justin Morrill College, "Science, Technology and
Human Values".
Helped to design Human Development course, 1970-71.
Chairman "Committee on Graduate Education" for Dept. of Human Development.
Served on All University Ad Hoc Committee for General Education, 1971-72.
Served on Human Development Seminar Committee, 1973-74.
Served on Human Development Undergraduate-Graduate Program Committee,1972- 74.
Served on College of Human Medicine Graduate Committee, 1974-77.
Co-Chairman of Group on Development in Human Development, 1974-76.
Coordinator of MSU-Cancer Group, 1974-1977.
Member of Ad-Hoc Cancer Center Planning Group, 1975.
Director of Cancer Colloquium Series at MSU, 1975-76.
Chairperson of the Reappointment, Tenure and Promotion Committee, 1976-78.
University Biohazards Committee, 1976-Pres.
Human Development and MSU Cancer Group Seminar Committees, 1976-77.
MSU Cancer Group Seminar Committee, 1977-78.
MSU Genetics Program Seminar Committee, 1977-78.
Mich. Branch, Tissue Culture Assoc. Symposium Committee, 1977-78.
Governor's Task Force on Registry Systems for Epidemiological Data,1977-78.
Argonne-Associated Universities Biology Symposium Committee, 1978-79.
Acting Chairperson of the Reappointment, Tenure and Promotion Committee,1978-79.
Chairman of Pediatrics and Human Development's Biohazard Committee, 1979.
Argonne-Associated Universities Biology Symposium Committee and the Symposium
Planning Committee, 1979-80.
Chairman of Pediatrics and Human Development's Program Evaluation Committee.
Ad hoc consultant to NIEHS committee on Environmental Mutagenesis, Fall 1979.
Ad hoc consultant to American Business Cancer Research Foundation, Inc., Fall, 1979.
Acting Assoc. Chairman, Dept. of Pediatrics and Human Development, MSU, Fall, 1980.
Scientific Consultant to Michigan Leukemia Foundation, 1980-82.
Executive Committee, Dept. of Pediatrics/Human Development, 1980-81.
Task Force Environmental Cancer and Heart and Lung Disease, Washington, DC, Jan.
1981.
NIOSH - Consultant, Oct. 1982.
National Academy of Science - Consultant - Asbestos and Human Health, Oct. 1982-83.
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State of Michigan - Critical Materials Committee, Fall, 1985-1987.
National Pancreatic Cancer Program of the Organ Systems Coordinating Center, NCI,
Spring, 1985-1989.
Governor's "Chronic Disease Advisory Committee", State of Michigan, 1988-90.
State of Michigan, "Genetic Advisory Committee", 1988-90.
Natl. Food Safety and Toxicology Center Fire and Biohazard Director, 1999College of Human Medicine Search Committee for Great Lakes Cancer Director, 2000-01.
Toxicological Sciences Reviewer 2002
Carcinogenesis Editorial Reviewer 2001.
Cancer Letters Reviewer, 2002.
Reviewer of many journals 2002-2008.
FELLOWSHIPS, AWARDS, PROFESSIONAL SOCIETIES
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Summa Cum Laude, Central Michigan University, 1956.
Student Council Senior Award, Central Michigan University, 1959.
Who's Who in American Universities and Colleges, 1960.
Argonne National Laboratory Student Research Participant, Summer 1959-60.
AEC Health Physics Fellowship, 1960.
Research Predoctoral Fellowship, 1960, Univ. of Indiana. (Received but not accepted.)
Fellowship to University of Michigan, 1960.
National Defense Education Act Predoctoral Fellowship, MSU, 1960-63.
Oak Ridge National Postdoctoral Fellowship, 1963-64.
American Cancer Society Postdoctoral Fellowship, Oak Ridge, 1964-65.
Sigma Xi
Kappa Mu Honorary Math Fraternity
AAAS
Genetics Society of America
New York Academy of Science, 1968.
American Men of Science, 1967.
Invited as discussant by the U.S. and Australian National Academy of Science for
symposium, "Recombination and Replication of Genetic Materials", Canberra, Australia,
Sept. 1967.
Member of Environmental Mutagenesis Society, 1969.
Consultant to Oak Ridge National Laboratory, 1970-72.
"Outstanding Educator of America" award, 1971.
Trainee to Workshop on Molecular Techniques in Developmental Biology at Univ. of
California, Summer, 1971.
National Career Development Award from National Cancer Institute, 1971-77.
Terminology Committee of the Tissue Culture Association, 1974-76.
Vice-President of the Michigan Branch of the Tissue Culture Assoc., 1976- 77.
President of the Michigan Branch of the Tissue Culture Assoc., 1978-79.
Attendee to NIH-NSF Workshop on Philosophical Ethics for Scientists and Engineers".
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Presented the "Searle" Award by the United Kingdom-Environmental Mutagen Society at
University of Sussex, England, Sept. 10, 1979 for "Pioneering work in mammalian DNA
repair and mutagenesis studies".
Member of the Society of Toxicology, 1981.
Elected on Council of Regional Chapter (Michigan) of Society of Toxicology, Jan.
1982-84.
Sigma Xi Senior Research Award, Spring, 1985.
MSU Distinguished Faculty Award, Winter, 1987.
Diplomate in General Toxicology, Summer, 1988.
Centennial Awardee from Central Michigan University, 1993.
Member of Michigan Department of Public Health, "Radon Committee”.
Award from MSU-Minority Medical Student Assoc., 1995.
Elected President, Sigma Xi Society-MSU, 1996-1997.
Scientific Achievement Award, Society of Toxicology, March, 2001.
Japan Society for the Promotion of Science award , Sept- Dec, 2001.
Internatl. Society of Stem Cell Research, Dec. 2003
Awardee of the Korean Ministry of Science and Technology “ Brain Pool “ award, Aug,
2006- Nov., 2006
TEACHING RESPONSIBILITY AT MICHIGAN STATE UNIVERSITY
1966-Present
Courses Taught:
1.
181, 182, 183 Natural Science Series, 1966-67
2.
191 for three terms, 1967-68
3.
191, EU-192, 193, 1968-69 (11 contact hours/weeks/terms/year)
4.
191, 192 Human Development, 1969-70
5.
Science, Technology and Human Values, Justin Morrill College, 1970, Spring
6.
Science, Technology and Human Values, Justin Morrill College, 1970, Fall
7.
Human Development, 1970, Winter
8.
Science, Technology and Human Values, Justin Morrill College, 1971, Spring
9.
Science, Technology and Human Values, Justin Morrill College, 1971, Fall
10.
Human Development course, 1972, Winter
11.
Human Development Minicourse, "Basic Genetics", 1972, Winter
12.
Human Development Minicourse, "Environment and Development", 1972, Spring
13.
Provost-Faculty Seminar, "Scientific concepts of human nature and their implications to
ethics", Spring, 1974.
14.
"Human Nature, Human Intervention and Human Development", Justin Morrill College,
1974, Winter
15.
Human Development 590, "Scientific concepts of human nature and their implications to
medical ethics", 1974, Fall (3 students).
16.
Human Development, Focal Problems, Fall, 1976.
17.
JMC 329 A & B, "Human Nature, Human Intervention and Human Development" Spring,
1977 and Spring, 1978.
18.
MSU University Extension Course, Bio. Sci. 405 Topics in Biological Science: "Cloning
and Genetic Engineering", Fall, 1978.
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Pediatrics and Human Development, PHD 590, Winter, 1979.
Pediatrics and Human Development, PHD 590, "A mutation theory of human disease",
Winter, 1979.
Focal Problems, "Medical Ethics", School of Human Medicine, Winter, 1982
Summer Institute for Gifted Students, Summer, 1982.
Summer Institute for Gifted Students, Summer, 1983.
Focal Problems, School of Human Medicine, Spring, 1984.
Genetic Graduate Student Seminar Course, "Somatic Cell Genetics", Winter, 1985.
Pediatrics and Human Development, PHD 590, 591, Fall, 1986, Winter, 1987.
Focal Problems, School of Human Medicine, Spring, 1987.
Focal Problems, School of Human Medicine, Spring, 1988.
Focal Problems, School of Human Medicine, Spring, 1989.
Focal Problems, School of Human Medicine, Spring, 1990.
Focal problems, School of Human Medicine, Fall, 1992.
Block II, School of Human Medicine, Spring, 1994.
Block II, School of Human Medicine, Spring, 1995.
Block II, School of Human Medicine, Spring, 1996.
Preceptor, School of Human Medicine, Spring, 1997.
Preceptor, School of Human Medicine, Spring, 1998.
Preceptor, School of Human Medicine, Fall, 1999.
Med School Lecturer on “ Theories of Carcinogenesis”, 1993-2002
ACADEMIC ADVISING
A.
Member of Ph.D. Committees
1.
N. Diaz (Food Science Dept.) 1970.
2.
M. Ringo (Zoology Dept.) 1968.
3.
A. Samuel (Entology Dept.) 1970.
4.
H. Harder (Biophysics Dept.) 1970
5.
R. Rubin (Zoology Dept.) 1970.
6.
R. Hoover (Zoology Dept.) 1970.
7.
D. Osborn (Biophysics Dept.) 1970.
8.
T. Hamilton (Biophysics Dept.) 1970.
9.
K. Lovell (Biophysics Dept.) 1970.
10.
L. Huang (Biophysics Dept.) 1971.
11.
N. Jenkins (Zoology Dept.) 1971.
12.
R. Short (Pharmacology Dept.) 1973.
13.
I. Skurnick (Biophysics Dept.) 1974.
14.
H. Brody (Philosophy Dept.) 1972.
15.
L. Yotti (Genetics Program) 1974.
16.
T. Glover (Genetics Program) 1975.
17.
R. Schultz (genetics Program) 1975.
18.
R. Bob Shenkar (Biophysics) 1976.
19.
P. Liu (Genetics Program) 1979.
20.
C. Knudson (Genetics Program) 1979.
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D. Doolittle (Pharmacology) 1979.
C. Marvel (Biochemistry) 1980.
B. Baranyi (Pharmacology/Toxicology) 1982.
T. Kavanagh (Toxicology) 1982.
J. Domoradzski (Biochemistry) 1984.
M. El-Fouly (Genetics Program) 1985.
M. Resgabek (Pathology) 1985.
M. Evans (Pathology) 1986.
B. Kuslikis (Pharmacology) 1986.
C. Hasler (Food Sci.), 1986.
K. Blair (Neurobiology), 1987.
H. Hassanain (Zoology), 1987.
S. Meiners (Biochemistry), 1988.
R. Vorce (Pharm. Toxicol.) 1988.
B. Sills (Pathology) 1989.
S. Ball (Pathology) 1989.
Yuh-Shan Jou (Genetics), 1989.
Jennifer Counts (Pharmacology/Toxicology), 1993.
K. Koa (Genetics), 1993
Nestor DeoCampo (Genetics, 1994)
Coleen Dowling-Warriner (Pharmacology/Toxicology), 1999
Stephanie Luster-Teasley (Chemical Engineering), 1998
Barbara Faubert-Kaplan, [ Pharmacology Toxicology]1995-2001
Courtney Sulentic [ Pharmacogy/Toxicology] 1993-1999.
Susan McKarns [ Pharmacology/Toxicology] 1995- 2001.
Andrea Saito [ Environmental Engineering ] 1999-2008
Rebecca Watson [ Pharmacology/ Toxicology] 2001Di Wu [ Soil Sciences] 1999-2001
Laura Jean Clifford,[ Dept. FoodScience and Human Nutrition], 1998-2002.
Ammie Bachman[ Pharm. Toxicology] 2001-2006]
Tak Ko [ Dept. Animal Sciences, 2006- ]
B. Member of Master's Committees
1.
Ginzberg (Biochemistry Dept) 1968.
2.
D. Krause (Entomology Dept.) 1970.
3.
B. Gunning (Zoology Dept.) 1970.
4.
R. Rothenberg (Pharmacology Dept.) 1974.
5.
D. Allen (Zoology Dept.) 1976.
6.
M. Adams (Pharmacology Dept.) 1976.
7.
C. Phillips (Bio-Science) 1976.
8.
K. Keller (Zoology Dept.) 1982.
9.
B. Upham (Civil and Environmental Engineering) 1994.
10.
B. Boddy, Civil and Environmental Engineering) 1995.
11.
Chia-jan Liu (Medical Technology) 1995-1997.
12.
Miodrag Guzvic- Serbia, 2004
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C.
Undergraduate Mentor
1.
Mr. James Beakey (Zoology-biochemistry) Spring 1970.
2.
Mr. Howard Brody (Biochemistry) Fall-Spring 1970-71.
3.
Mr. Robert Rintel (NSF-Summer Student), 1981.
4.
Mr. Andrew Frutkin (NSF-Summer Student), 1986.
5.
Ms. Kirsten Benjamin (NSF-Summer Student), 1986
6.
Ms. Helen Chang, Summer, 1986.
7.
Mr. Ichiro Matsumuro, Summer, 1986.
8.
Ms. Susan Rutten, Fall, 1990.
9.
Mr. Tyler Koski, Winter-Winter, 1994-1995.
10.
Ms. Maki Saito, Fall, 1996
11.
Ms. Thuy-Ahn Tran, Spring, 1997, McNair student
12.
Ms. Nwamaku Dallah, Spring, 1997, McNair student
13.
Ms. Tiffiney Lee, Spring, 1997, McNair student
14.
Mr. Ifeanyi Umeh, 1996-1997
15.
Mike Carbone, 1998-2000
16.
Curtis Pickering, 1999
17.
Darin Padula, 1999-2000
18.
Vishal Malhotra, Howard Hughs fellow, 2000-2001
19.
Katy King, 2000-2002
20.
Jennifer Zuker, 2001-2003
21.
Jacob Scott, 2000-2002
22.
Chad Coe, 2000-2004
23.
Mark Hagerty, 2003
24.
Ben Sopczynski, 2008
D.
Graduate Reading Course Mentor
1.
2.
3.
4.
Mr. Samir Mansy, Fall 1970.
Mr. Laurence, Summer-Winter 1971.
Mr. Antonio Munera, Winter 1972.
Mr. Hamdy Hassanain, 1984
E.
PreMedical Advisor 17 Justin Morrill students (1970-74).
F.
Independent study advisor to Justin Morrill College students
T. Estroff, B. Bruns, T. Beers (1970). Independent study advisor to Scott Newhart, M.
Worden. T. Barrett (1971); to E. Retzel, Spring 1973); to Tom Catline, Fall 1974; to
Elizabeth Gordon, Fall, 1977; to Brian Foresman, Fall, 1977, to Brian Foresman, Winter,
1978, to Linda Wennerberg, Winter, 1978; Dave McGreaham, Summer 1980. Gary
Ferenchick, Summer 1981, Sandy Flynn, Winter, 1982, Sue Freeman, Winter, 1982;
Beth O'Malley, Winter, 1982.
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G.
Genetic Rotation Students and Medical Students
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17.
H.
Ken Dudley (Fall, 1975).
Judy Runnells (Winter, 1975).
Bob Pearson (Spring, 1976).
Marilyn Leonard (Summer, 1976).
Tom Rudolph (Fall, 1976).
Steve Warren (Winter, 1977).
Reza Noori-Daloii (Winter, 1977).
Mary McGrae (Summer, 1986).
Mary Frick (Summer, 1988).
Onyinye Onyekwere (Fall, 1992).
Christine Kim (1992-93).
Nestor De Campo (Fall, 1993).
Zhang Hang (Fall, 1993).
Hye Youn Cho (Fall, 1994).
Troy Close (1995).
Colleen Dowling (Spring, 1996)
Karl Meisel ( Spring, 2003)
Postdoctoral Fellows and Visiting Foreign Scholars
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Y.Q. Huang, Republic of China, 1981
Clarita Rubinstein, Argentina, 1981
Chen Tzuu-hui, Republic of China, 1981-1982
Chang Xian-chiao, Republic of China, 1982-83
Lin Zhong-xiang, Republic of China, 1984-1985
Andrzej Jurck, Poland, 1986-1987.
Cy Jone, U.S.A.
Andrew Medcalf, England
Margaret Wade, U.S.A.
Rita Loch-Caruso, U.S.A.
Saw Yin Oh, Malasia, 1986
Edwin de Feijter, Netherlands, 1988
David Bombick, U.S.A., 1987
Ghulam Kalimi, India, 1989-90
Emmanuel Dupont, France, 1989Russ Malcolm, U.S.A., 1990
Glaucia Maria Machado-Santelli, Brazil, 1990
Raj Sharma, England, 1990
Ole Vang, Denmark, 1991
Eimert de Feyter, Netherlands, 1991
Howard Evans, England, 1991
Nam Deuk Kim, Korea, 1991
Carmel Mothersill, Ireland, 1991
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Colin Seymour, Ireland, 1991
Koichi Nomata, Japan, 1992
Fiona Lyng, Ireland, 1992
Tomonori, Hayashi, Japan, 1993
Melinda Wilson, U.S.A., 1993
Ikue Morita, Japan, 1994
Kyng Sun Kang, Korea, 1994
Byung Choel Kang, Korea, 1996
Kimie Sai, Japan, 1996
Giuseppe Carruba, Italy, 1996
Hye-Kyung Na, Korea, 1996
Junji Suzuki, Japan, 1997
Jivka Petrova Halkova, Bulgaria, 1999
Anelia Dafinova Horvath, Bulgaria, 1999
Kimie Sai, Japan, 1999
Giuseppe Carruba, Italy, 1999
Alice Teng, Taiwan, 2000
Nam Deuk Kim, Korea, 2000
Jun Kanno, Japan, 1999
Hsien-Chiao Teng, Taiwan, 2000
Varban S. Ganev, Bulgaria, 2000
Toshio Mori, Japan, 2000
Tohrue Inoue, Japan, 2000
Yasushi Nakamura, Japan, 2000
Shen Cherng, Taiwan, 2000
Anelia Dafinova Horvath, Bulgaria, 2001
Therese Solderdahl- Karolinska, Sweden, 2002.
Miroslav Machala- Czechoslovakia, 2002.
Dr. Noguchi, University of Nasasaki, 2003
Manish Neupane- Nepal, 2004
Therese Solderdahl. Karolinska, Sweden, 2004
Miodrag Guzvic, Serbia, March 2005-Aug. 2005
Dr. Sergei Petrenko, Kiev, Ukraine, Fulbright Fellow, May- August 2005
Dr. Antonella Leone, Ispra-Milan, European Commission, Sept. 2007- Oct. 2007
Dr. Feng Shi, China- Visiting Clinical Oncologist, 2009
Christina Munteanu - Visiting Scholar Romania, 2009
Milena Veslinovic- Visiting Scholar- Serrbia, 2009
Ondrej Adamovsky., Fulbright Fellow , Czech Republic, 2008
RESEARCH
Molecular basis for radiation and chemical induced biological damage in human cells.
1.
2.
Ultraviolet light induced pyrimidine dimers in mammalian DNA.
Repair mechanisms in human and high plant material.
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3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
Molecular basis of photosensitizing drugs.
Molecular basis for cancer-inhibiting drugs.
Effect of drugs (caffeine, LSD, platinum compounds, hormones) on human cells.
Mutation and epigenetic theory of cancer, aging and atherosclerosis.
Human adult stem cell research
Development of in vitro assays for environmental mutagens, tumor promoters
and teratogens.
Role of intercellular communication in teratogenesis, tumor promotion, immune-,
neurotoxicology and reproductive dysfunction.
Role of oncogenes/tumor suppressor genes in gap-junctional intercellular
communication.
Role of human stem cells in cancer and tissue regeneration.
Identification of Oct-4 as stem cell and cancer stem cell marker.
120