ANXIETY DISORDERS AND DEPRESSION IN CHILDREN AND ADOLESCENTS Acknowledgements: Most of the information included in this chapter was obtained from the Handbook of Psychiatry, 2005, Mental Health Information Centre of SA, Department of Psychiatry, University of Stellenbosch. Chapter by Professor Susan Hawkridge, Dr Linda Keyter and Dr Bennie Steyn A. ANXIETY DISORDERS Separation anxiety disorder Separation anxiety is a normal phenomenon in children during the toddler years. It begins at 6-8 months and lasts until 18 months, after which it gradually diminishes. When the child is better able to understand, anxiety (including separation anxiety) is influenced more by the reality of the child’s environment. Any child will be anxious when, for example, s/he attends a new school for the first time, but the healthy child will quickly adjust. In some children, separation from the mother remains anxiety provoking, and this can develop into a typical syndrome such as school refusal. There is often a family history of anxiety disorders, particularly separation anxiety disorder in the mother. Family pathology is often present. Sometimes the mother suffers from depression or another psychiatric or general medical illness. Marital conflict between the parents with threats that one of them will leave home is also a factor that must be taken into account in children with separation anxiety disorder. The mother may for one or other reason be anxious about her role as a parent (often she was an orphan, a foster-child or herself unhappy in childhood). Often the family is very enmeshed, with over-involvement of grandparents or overprotection of the child, etcetera. The problem may also lie with a mother who herself experiences separation anxiety and wants to keep her child with her. The condition is often precipitated by an event such as the death or illness of a family member, a change in environment, a new school etcetera. Generalised anxiety disorder in children Generalised anxiety disorder appears to be more common in families from higher socio-economic levels, as well as in small families preoccupied with academic performance. It is more often seen in first-born children. Boys and girls are equally affected. There is often a family history of anxiety disorders. Associated symptoms include perfectionism, over-conscientiousness and precocious maturity. Habits such as nail biting and hair pulling may also be present. Often these children are unwilling to participate in sport or other group activities, and social or other phobias may also be present. Panic disorder in children Panic disorder does occur in children, and may be misdiagnosed as asthma, “hyperventilation” or “manipulative behaviour”. Social phobia (social anxiety disorder) in children Children differ just as much as adults in their social tendencies. Some converse easily with strangers, while others take longer to become accustomed to someone they don’t know. The latter have also been called “slow to warm up” children. It is important not to label behaviour that falls in a child’s normal developmental spectrum as a “disorder”. Associated symptoms include a lack of self-confidence and an inability to act assertively. Often a further diagnosis can be made, for example, generalised anxiety disorder, and the condition may be complicated by school refusal. Depressed mood frequently develops as a result of social isolation or poor school performance. Selective mutism It has been speculated that selective mutism might be a subtype of social phobia, because the symptoms only occur in social situations,5 and up to 90% (but not all) of these children do meet the criteria for social phobia. In isolated cases, a child may develop the syndrome after an identifiable stressor. When this occurs it could possibly be seen as a form of posttraumatic stress disorder. The prevalence is 3-8 per 10 000. This rare condition occurs more frequently in girls than in boys. These children do speak to their parents and familiar family members, but refuse to converse in the normal way at school. They may sometimes use gestures or whisper single words. Onset is usually at the age of 5 or 6 years. There may be a history of delayed or abnormal development of speech that possibly contributes to the problem. High levels of anxiety and overprotection are often found in the family. Other problems such as oppositional behaviour or outbursts are also often present at home. Thus genetic, developmental and family factors are being studied as possible causes. Obsessive-compulsive disorder (OCD) in children Normal children enjoy ritualistic play and often like to carry out actions in a certain order. Magical thinking is a normal phenomenon. It means that one has to do something in order to prevent something else (bad) happening. Any child, when he is anxious, feels safer in the presence of familiar objects and habits, and a tendency to obsessional rituals is reinforced under stress. There is a developmental stage around 5-8 years when ritualistic games and behavioural occur normally. Rituals and obsessional behaviour only become a disorder if they cause the child distress or impair his functioning. Although most people with OCD are adults, many of them can describe a very early onset of their symptoms. In particular, children who suffer from Tourette’s disorder are inclined to develop OCD early, usually around 11 years of age. Obsessions: 1 Recurrent and persistent thoughts, impulses or images that are experienced as intrusive and inappropriate, and cause distress 2 The above is not just excessive worry about real problems 3 The child attempts to suppress the thoughts etc., or to neutralise them with another thought or action 4 The child is aware that the thoughts are his/hers, i.e., they do not originate outside him/herself Compulsions: 1 Recurrent behaviour (e.g., hand washing) or thoughts (e.g., praying, counting) that the child feels compelled to carry out as a response to obsessions or certain “rules” 2 The goal is reduction of anxiety or prevention of a terrible consequence; the connection between the two is unrealistic Specific phobias Irrational fears for part of any child’s developmental process, especially during the phase of magical thinking (around 4 - 7 years). In children these fears particularly concern the natural environment and blood/injection/injury fears. Sometimes there is a preceding traumatic event and sometimes not. Usually this is a passing stage, but in some children it develops into specific phobias, which by definition impair functioning or development. Careful history taking can exclude the possibility of other psychiatric disorders (e.g., OCD, psychosis), and the child can then be referred for psychotherapy. In children this therapy should preferably be done by a trained child psychologist, due to the danger of traumatisation during systematic exposure to the feared stimulus. Posttraumatic stress disorder Posttraumatic stress disorder (PTSD) occurs in children as well as adults. In our community it is more common than previously thought, with more than 12% of teenagers in high school meeting the diagnostic criteria. Children who suffer from PTSD are often referred on account of nightmares, sleep difficulties, tearfulness, school refusal, deterioration in school work, “obsessive” behaviour, “conversion disorders”, social withdrawal, separation anxiety, oppositionality, irritability or after suicide attempts. It must be remembered that children, especially young children, do not often have the ability to describe symptoms clearly. The possibility of this disorder must always be borne in mind, because especially following sexual abuse, the child has often not told anyone of the event. If the diagnosis is not made and the child does not receive appropriate treatment, the child’s further emotional development can be impaired. We have little information concerning treatment outcome in local conditions, but preliminary studies suggest that effective treatment can lead to relief of symptoms and improvement in functioning, at least in the short term.10 Undiagnosed and untreated PTSD can have a poor long term outcome, including personality disorders, depressive disorders, behavioural disorders and substance abuse. In general, treatment comprises psychotherapy (play therapy in younger children) and where appropriate, medication. B. DEPRESSIVE DISORDERS From the time of birth, signs of emotion can be observed in children. They are sometimes happy and sometimes not. Psychodynamic theories of the causes of depression have in the past led some to hypothesise that young children cannot experience depression. More recent research has shown that, on the contrary, young children can become depressed, but that the clinical presentation can be variable according to developmental stage. 12 There is sufficient evidence to state that mood disorders in children are fundamentally the same illnesses as in those adults. Genetic factors: In general there is an increased incidence of mood disorders in the children of parents with mood disorders and in the family members of children with mood disorders. Having one parent with a mood disorder doubles the chances of a mood disorder affecting the child, and having two parents with mood disorders quadruples those chances.12 Biological factors may also play a role.12 Social factors: The fact that identical twins do not have 100% concordance for mood disorders implies that there is a role for non-genetic factors. A boy whose father dies before the son is 13 years old has an increased chance of suffering from a mood disorder. Adolescents with a history of chronic physical illness, previous suicide attempts, childhood anxiety disorders or childhood major depression have an increased risk of depression, as do those who are abnormally dependent on the approval of others or who have poor social skills, or who are unhappy about their school performance.3 A high incidence of parental aggression, marital conflict, blaming and judgemental discipline is found in the families of children with depression. C. SUICIDE AND SUICIDE ATTEMPTS 1 Suicide16 Successful suicide is occasionally described in prepubertal children, but occurs rarely. It appears that although children often want to die, they lack the requisite practical skills to commit suicide successfully. After the age of 14 years, successful suicide increases markedly. The incidence is higher in boys than in girls, and there are often associated problems - substance abuse, behavioural problems, conflict with authorities. The method chosen influences the outcome, thus the most common method in successful suicide in children is firearms. If a young patient does commit suicide, remember that the family, and possibly you yourself, may need support and counselling. 2 Suicide attempts16 The incidence of suicide attempts is higher in girls than in boys, and also rises steeply after puberty. Suicide threats and attempts must always be viewed in a serious light. All children and adolescents who attempt suicide must be thoroughly evaluated a) for depression b) for other problems that have led to a feeling of despair, and c) for other psychiatric disorders. Characteristics of adolescents who make suicide attempts: 1) 90% are female, 10% male 2) Medication overdose is the most common method used 3) There is a high incidence of family pathology and psychiatric disorders in the families of these patients 4) There is often a history of suicide/suicide attempts in the family 5) The attempt is often impulsive and not premeditated 6) There is nearly always an immediate precipitant, whereof the following are the most common: a) Conflict with parents b) Breaking up with boy/girlfriend c) Disciplinary crisis at school. The typical profile of the less seriously intended adolescent parasuicide is thus a girl who impulsively takes a small overdose of tablets following a relationship crisis or an argument with her parents. It is however important to remember that any suicide attempt can be fatal, whether or not it is so intended. High-risk suicide attempts are characterised by: 1) The presence of signs of depression before and after the suicide attempt 2) Planning 3) More serious attempt, e.g., a very large quantity of pills 4) The presence of a suicide note 5) Previous attempted suicide 6) Secrecy, tells nobody, or takes overdose when there is a good chance that s/he will not be found for a long time 7) The use of certain methods, e.g., firearm, gassing, hanging, etc. 8) The presence of severe problems without a possible solution that have led to a feeling of despair, e.g., ongoing incestuous abuse 9) After the attempt, there is persistence of suicidal ideation 10) Associated problems with authorities, alcohol or substance abuse 11) Male gender. References 1. Diagnostic and Statistical Manual of Mental Disorders (4th Edition). Washington: American Psychiatric Association, 1994. 2. Silove D, Manicavasagar V, Curtis J, Blaszczynski A. 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Fluvoxamine for phobia of storms. Acta Psychiatr Scand 1999;100(3):244-5. 10. Seedat S, van Nood E, Vythilingum B, Stein DJ, Kaminer D. School survey of exposure to violence and posttraumatic stress symptoms in adolescents. Southern African Journal of Child and Adolescent Mental Health 2000;12(1):38-44. 11. Seedat S, Zungu-Dirwayi N, Kaminer D, Lockhat R. An open trial of citalopram in adolescents with posttraumatic stress disorder. Int Clin Psychopharmacol 2000;(in press). 12. Wessely S, Rose S, Bisson J. Brief psychological interventions (“debriefing”) for trauma-related symptoms and the prevention of post traumatic stress disorder. Cochrane.Database Syst Rev 2000(2):CD000560. 13. Hawkridge S. Assessment and treatment of major depression in adolescents. Specialist Medicine 1997;XIX(4): 32-41. 14. Emslie GJ, Weinberg WA, Kowatch RA. Mood disorders. In: Coffey CE, Brumback RA, eds. Textbook of Pediatric Neuropsychiatry:359-392. 15. Birmaher B, Brent D. Practice parameters for the assessment and treatment of children and adolescents with depressive disorders. JAACAP 1998;37(Oct. Suppl):10. 16. Carlson GA, Abbott SF. Mood disorders and suicide. In: Kaplan HI, Sadock BJ, eds. Comprehensive Textbook of Psychiatry/VI. Baltimore: Williams & Wilkins, 1995:2367-2391.