th
10.30-11.00 Tea/Coffee and informal discussions
Introduction
11.00-11.05 Prof Steve Brown
11.05-11.15 Dr Tom Weaver
Neurobiology and sensory
11.15-11.30 Prof Elizabeth Fisher: “NeuroMouse”
11.30-11.45 Prof Jean Manson: “From human neurogenetics to murine models”
11.45-12.00 Prof Marcella Votruba/Prof Ian Jackson: “Mouse Eyes and Vision Research Consortium”
12.00-12.15 Group discussion
Development and Differentiation
12.15-12.30 Prof Claus Nerlov: “Genetics of normal and malignant haematopoiesis”
12.30-12.45 Prof Christopher Buckley/Dr Jill Norman: “Tissue Remodeling and Fibrosis”
12.45-13.00 Prof Andrew Copp: “Developmental Anomalies Consortium”
13.00-13.10 Group discussion
13.10-13.30 Lunch and portal demonstration
Immunity
13.30-13.45 Prof Werner Muller: “Immune System”
13.45-14.00 Prof Peter Andrew: “Susceptibility and resistance to Streptococcus pneumoniae”
14.00-14.15 Prof David Hume: “Macrophage Biology and Innate Immunity”
14:15-15.25 Group discussion

Industrial/Translational
14.25-14.40 Prof Dario Alessi: “Mouse Models to Accelerate Drug Discovery”
Respiratory and Circulatory
14.40-14.55 Dr Charlotte Dean/Dr Matthew Hind: “Respiratory development and disease”
14.55-15.10 Prof Patricia Munroe: “Cardiovascular Trait Consortium”
15.10-15.20 Tea/Coffee
Metabolic
15.20-15.35 Dr Quentin Anstee: “UK GoLD: Genetics of Liver Disease”
15.35-15.50 Prof Robert Unwin/Dr Matthew Bailey: “Kidney and Urogenital System”
15.50-16.05 Prof Antonio Vidal-Puig/Dr Tony Coll: “MODO: Models Of Diabetes and Obesity”
16.05-16.20 Prof Rajesh Thakker: “Models for Disorders of Bone and Cartilage”
16.20-16.35 Dr Jane Cox: “NMR metabolic profiling of body fluids”
16:35-16.45 Group discussion
Final discussion and next steps
16:45-17:00 Final discussion and next steps
Underlined name = presenter

Guidelines for consortium presentations

All talks should fit comfortably within the allotted 15 minute slot. Talks should be a maximum of 10 minutes long, allowing 5 minutes for questions and changeovers

Presentations should focus on activities and deliverables that the consortium will be engaging in or has already begun. In particular, objectives should be stated that will add value to the IMPC project

Suggested content for presentations:
(i) Aims of the Consortium: research themes addressed and overarching aims
(ii) Consortium members: brief outline of the groups and research areas
(iii) Specific plan of action: what is your Consortium going to deliver, e.g. specific secondary screens?
(iv) Current activities on the Mouse Network (including potential funding applications)
(v) Any issues for MRC Harwell to address

Name Consortium
Emmanuelle Bitoun Neuromouse
Peter Oliver
Elizabeth Fisher
Neuromouse
Neuromouse
David Hume
Julia Dorin
Macrophage Biology and Innate Immunity
Macrophage Biology and Innate Immunity
Andreas Lengeling Macrophage Biology and Innate Immunity
Rajesh Thakker Models for Disorders of Bone and Cartilage
Graham Williams
Stuart Ralston
Peter Andrew
Models for Disorders of Bone and Cartilage
Models for Disorders of Bone and Cartilage
Host determinants of susceptibility and resistance to disease due to Streptococcus pneumoniae
Dario Alessi
Quentin Anstee
Alastair Burt
Jeremy Lambert
Jean Manson
Giles Hardingham
Kim Summers
Charlotte Dean
Matthew Hind
Mouse Models to Accelerate Drug Discovery
UK GoLD
UK GoLD
UK GoLD
From human neurogenetics to murine models
From human neurogenetics to murine models
From human neurogenetics to murine models
Respiratory development and disease research consortium
Respiratory development and disease research consortium
Antonio Vidal-Puig MODO Consortium: Models Of Diabetes and Obesity
Guy Rutter
Antony Coll
MODO Consortium: Models Of Diabetes and Obesity
MODO Consortium: Models Of Diabetes and Obesity
Dominic Withers
Werner Muller
Kathryn Hentges
Claus Nerlov
MODO Consortium: Models Of Diabetes and Obesity
Immune System
Immune System
Genetics of normal and malignant haematopoiesis
Robert Unwin
Matthew Bailey
Kidney and Urogenital System
Kidney and Urogenital System
Patricia Munroe Cardiovascular Trait Consortium
Pim Van der Harst Cardiovascular Trait Consortium
Andrew Tinker Cardiovascular Trait Consortium
Christopher Buckley Tissue Remodeling and Fibrosis Research Consortium
Jill Norman
David Abraham
Tissue Remodeling and Fibrosis Research Consortium
Tissue Remodeling and Fibrosis Research Consortium
Marcela Votruba
Ian Jackson
Erwin Pauws
Nick Greene
Mouse Eyes and Vision Research Consortium
Mouse Eyes and Vision Research Consortium
Developmental Anomalies Consortium
Developmental Anomalies Consortium
Email emmanuelle.bitoun@dpag.ox.ac.uk peter.oliver@dpag.ox.ac.uk e.fisher@prion.ucl.ac.uk david.hume@roslin.ed.ac.uk
julia.dorin@hgu.mrc.ac.uk andreas.lengeling@ed.ac.uk rajesh.thakker@ndm.ox.ac.uk
graham.williams@imperial.ac.uk stuart.ralston@ed.ac.uk pwa@le.ac.uk
d.r.alessi@dundee.ac.uk
quentin.anstee@ncl.ac.uk
alastair.burt@ncl.ac.uk j.j.lambert@dundee.ac.uk jean.manson@roslin.ed.ac.uk
Giles.Hardingham@ed.ac.uk kim.summers@roslin.ed.ac.uk
c.dean@har.mrc.ac.uk
m.hind@imperial.ac.uk
ajv22@cam.ac.uk g.rutter@imperial.ac.uk
apc36@cam.ac.uk
d.withers@ucl.ac.uk
Werner.muller@manchester.ac.uk
Kathryn.Hentges@manchester.ac.uk cnerlov@ed.ac.uk
robert.unwin@ucl.ac.uk
matthew.bailey@ed.ac.uk
p.b.munroe@qmul.ac.uk
p.van.der.harst@umcg.nl a.tinker@ucl.ac.uk c.d.buckley@bham.ac.uk
j.norman@ucl.ac.uk
david.abraham@ucl.ac.uk
votrubam@cardiff.ac.uk
ian.jackson@hgu.mrc.ac.uk
e.pauws@ich.ucl.ac.uk n.greene@ich.ucl.ac.uk

MRC Head Office
Dr Claire Newland MRC Programme Manager, Molecular & Cellular
Medicine Board
Other external delegates
Jane Cox
Alastair Poole
Imperial College London. Nuclear magnetic resonance spectroscopy metabolic profiling of body fluids.
Professor of Pharmacology and Cell Biology, Bristol
Platelet Group, Bristol Heart Institute
Manlio Vinciguerra The Institute of Hepatology, London
Harwell delegates
Tom Weaver Director of the Mary Lyon Centre: Harwell national facility for mouse functional genetics. IMPC member and Project Leader for MRC IMPC funding.
Steve Brown Director of MRC Mammalian Genetics Unit. Chairman of IMPC. Research group leader: molecular genetics and pathobiology of deafness.
Ann-Marie Mallon Head of BioComputing: providing underpinning support for developments in mouse phenotyping and next generation sequencing. Partner in the IMPC Data
Coordination Centre.
Sara Wells
Heather Cater
Michelle Stewart
Martin Fray
Tertius Hough
Lydia Teboul
Hilary Gates
Nanda Rodrigues
Paul Potter
Head of Operations of the Mary Lyon Centre: Mouse breeding and phenotyping
In Vivo phenotyping specialist and team leader
Mouse breeding and phenotyping team leader, NACWO
Head of the Biological Resources Group. Covering ES cell culture, microinjection, the frozen embryo and sperm archive, as well as mouse imports/exports.
Group leader of Clinical Pathology: Blood based phenotyping tests (clinical chemistry, FACS, haematology & NMR).
Head of Transgenics: Management of gene expression imaging and quality control of alleles; technological support for genotyping, production and use of targeted alleles.
External Funding Manager and IMPC scientific engagement.
Scientific Business Manager and IMPC scientific engagement.
Group Leader: Disease Model Discovery and
Translation. Development and characterisation of models of age-related, late onset or chronic disease, including genetics of ageing, immunosenscence, renal disease and macrophage signaling pathways.
Claire.Newland@headoffice.mrc.ac.uk
J.Cox@researchinliver.org.uk a.poole@bristol.ac.uk
M.Vinciguerra@researchinliver.org.uk t.weaver@har.mrc.ac.uk
s.brown@har.mrc.ac.uk
a.mallon@har.mrc.ac.uk
s.wells@har.mrc.ac.uk
h.cater@har.mrc.ac.uk
m.stewart@har.mrc.ac.uk
m.fray@har.mrc.ac.uk
t.hough@har.mrc.ac.uk
l.teboul@har.mrc.ac.uk
h.gates@har.mrc.ac.uk
n.rodrigues@har.mrc.ac.uk
p.potter@har.mrc.ac.uk

Dominic Norris
Roger Cox
Group Leader: Cilia development and disease. Genetics, cell biological and biochemical studies of ciliogenesis, left-right patterning and cilia-related disease.
Group Leader: Genetics of Type 2 Diabetes. Screening
ENU archive for new mouse models for type 2 diabetes; functional identification of genes identified in human
GWAS studies for diabetes and obesity and new models of insulin resistance and secretion.
Pat Nolan Group Leader: Neurobehavioral genetics. Molecular basis of mammalian behaviour screening ENU mutants for affects on the circadian clock and cognitive timing mechanisms.
Andy Greenfield Group Leader: Molecular genetics of sexual development. MAP kinase signaling in molecular events required for testis determination.
Abraham Acevedo Group Leader: Neurodegenerative genetics. Discovery of modifier genes of neurodegenerative disorders:
Huntington's disease (HD) and Amyotrophic Lateral
Sclerosis (ALS).
Deen Quwailid Head of Genotyping and Mutation detection Screens
(GEMS) core facility. Providing high-throughput molecular genetic technologies including genotyping and genetic mapping; mutation detection and maintaining and screening the Harwell ENU archive of various tissues and spermatozoa from ENU-treated mice.
Ruairidh King
Amanda Pickard
Dee Lynch
Angie Bimpa
Gemma Codner
Alison Walling
Hugh Morgan
Andy Blake
Graduate Intern: external funding and IMPC scientific engagement.
Deputy manager of the frozen embryo and sperm archive
ES cell laboratory manager
Coordinator of gene expression screen
Coordinator of Quality Control: Molecular validation of transgenic embryonic stem cells and mouse material.
Group Leader: LIMS Software Development team: providing tools for data capture, validation and export of data from all aspects of mouse breeding and phenotyping
Lead developer for Data Coordination Centre
Senior Bioinformatician: MRC Mouse Network Portal
Webmaster d.norris@har.mrc.ac.uk
r.cox@har.mrc.ac.uk
p.nolan@har.mrc.ac.uk
a.greenfield@har.mrc.ac.uk
a.acevedo@har.mrc.ac.uk
m.quwailid@har.mrc.ac.uk
r.king@har.mrc.ac.uk
a.pickard@har.mrc.ac.uk
d.lynch@har.mrc.ac.uk a.bimpa@har.mrc.ac.uk
g.codner@har.mrc.ac.uk
a.walling@har.mrc.ac.uk
h.morgan@har.mrc.ac.uk
a.blake@har.mrc.ac.uk