Molecular Mechanisms and Physiological
Consequences of Protein Aggregation
June 21stto June 26th
Palm Beach, Florida
Organizers:
Matthew Chapman
University of Michigan, Ann Arbor, Michigan
and
Roland Riek
ETH Zurich, Switzerland
Sunday, June 21, 2015
Time
4:00 p.m. to 9:00 p.m.
Title/Topic Event
Conference Registration
Keynote Lecture
Keynote Lecture
Welcome Mixer?
Sue Lindquist, MIT
Virginia Lee, University of Pennsylvania
Monday, June 22, 2015
Time
08:00 am to 9:00 pm
Title/Topic Event
Conference Registration
08:00 am to ?
Session 1; Amyloid Structure
Session Chair and Speaker
“Micro Crystals Reveal Mega Insights into Amyloid
Structure”
Speakers
“Using Solid State NMR to Probe the Functional
Amyloid State”
“High Resolution Structural Insights into Distinct
Amyloid Species Derived from the Same Peptide”
“3-Dimensional Structural Studies of Pathogenic
Amyloids”
coffee break
short talks selected from abstracts
Lunch
9 February 2016
David Eisenberg, UCLA
Christiane Ritter, Helmholtz Center for
Infection Research
Stephen Meredith, U. of Chicago
Beat Meier, ETH Zurich
Session 2; Mechanisms of Protein Aggregation in
Vitro
Session Chair and Speaker
“Molecular Insights into Cooperative Protein
Folding”
Speakers
“Protein Aggregation from Theory to Reality”
“Protein Aggregation of Beta-Microglobulin at the
Atomic Level”
”The Molecular Theory of Protein Aggregation”
short talks selected from abstracts
Jane Clark, Cambridge
Tuomas Knowles, Cambridge
Sheena Radford, Leeds
Rohit Pappu, Washington University
Tuesday, June 23, 2015
Time
Title/Topic Event
08:00 am
Session 3; Ordered Protein Aggregation and
Nanotechnology
Session Chair and Speaker
“The Amyloid World Hypothesis”
Speakers
“Amyloid Nanotubes”
“Replication of Amyloids in vitro and in vivo”
“Using Designer Gamma Bodies to Probe Amyloid
Assembly”
coffee break
short talks selected from abstracts
Lunch
Session 4; Functional Amyloid
Session Chair and Speaker
“Putting Yeast Prions to Work”
Speakers
“Diversity and Biogenesis of Microbial Amyloids”
“Long Term Memory Potentiation”
“The Biology of Hydrophobins”
short talks selected from abstracts
Ehud Gazid, Tel Aviv University
John Tovar, John Hopkins
Claudio Soto, University of Texas at
Houston
Peter Tessier, RPI
Tricia Serio, University of Arizona
Daniel Otzen, Aarhus University
Eric Kandel, Columbia University
Margaret Sunde, University of Sidney
Wednesday, June 24, 2015
Time
Title/Topic Event
08:00 am to ?
Session 5; Proteotoxicity and Aging
Session Chair and Speaker
“What Goes Wrong in Amyloid-Related
Toxicity”
Speakers
“Toxicity of Cellular Protein Aggregates”
“The Mechanism of Toxicity of Mammalian
9 February 2016
Ralf Langen, USC
Bill Balch, Scripps Research Institute
Adriano Aguzzi, University of Zurich
Prions”
“In vivo NMR of α-synuclein Reveals Structure
and Toxicity Relationships”
coffee break
short talks selected from abstracts
Lunch
Session 6; Mechanisms of In Vivo
Amyloidogenesis
Session Chair and Speaker
“In vivo Amyloid Formation”
Speakers
“Amyloid-Induced Proteostatic Meltdown”
“Mass Spectrometry on Living Cells”
“How Protein Aggregates are Cleared by the
Autophagy System”
short talks selected from abstracts
Phil Selenko, FMP Berlin
Hilal Lasheuel, ETH Zurich
Rick Morimoto, Northwestern
University
Paula Picotti, ETH Zurich
Ron Kopito, Stanford
Thursday, June 25, 2015
Time
08:00 am to 9:00 pm
Title/Topic Event
Conference Registration
08:00 am to ?
Session 7; Cellular Response and
Pathogenesis
Session Chair and Speaker
“Cellular Responses to Protein Aggregation”
Speakers
“Flavenoids can Reset Protein Homeostasis in
Aging”
“Interaction Maps of the Protein Network”
“Cellular Checkpoints in the Protein Folding
Network”
coffee break
short talks selected from abstracts
Lunch
Session 8; Mechanisms of In Vivo
Amyloidogenesis
Session Chair and Speaker
“Toxicity of α-Synuclein to Membranes”
Speakers
“Moving Amyloid Deposits Between Cells”
“Fighting Fire with Fire: Amyloid Interruption
of Amyloid Formation”
“Extracellular Amyloids Produced by Staph
cause Membrane Toxicity”
short talks selected from abstracts
Friday, June 26, 2015
9 February 2016
Andy Dillin, UC Berkeley
Pam Maher, Salk Institute
Jonathan Weissman, UCSF
Lila Gierasch, University Mass Amherst
Andrew Miranker, Yale University
Marc Diamond, Washington University
Joel Buxbaum, Scripps Research
Institute
Blaise Boles, University of Iowa
Time
Title/Topic Event
08:00 am to ?
Session 9; Therapeutic Interventions
Session Chair and Speaker
“Chemical and Biological Strategies that Adapt
the Proteostasis Network to Ameliorate
Amyloid Toxicity”
Speakers
“Mechanism of Amyloid Beta Aggregation and
the Role of Natural Inhibitors”
“Small Molecules that Inhibit Amyloid
Formation”
“Rational Design of Small Molecules that
Ameliorate α-synuclein Toxicity”
coffee break
short talks selected from abstracts
END OF CONFERENCE
For additional information contact:
FASEB Science Research Conferences
9650 Rockville Pike
Bethesda, MD 20814
www.faseb.org/src
9 February 2016
Jeff Kelly, Scripps Research Institute
Sara Linse, Lund University
David Schubert, Salk Institute
Fredrik Almqvist, Umea University