Spring Seminars 2014 The Rector Magnificus and 5 deans of VU will be your lecturer during the Extensus Spring Seminars and will introduce you to their field of study. Venue: room 14A-36 main building VU University Amsterdam, De Boelelaan 1105, 1081 HV Amsterdam Wednesday April 2nd 18.00-18.45 Albert Feilzer, dean Faculty of Dentistry ACTA Safety aspects of jewelry, piercings, cosmetics and biomaterials 19.00-19.45 Peter Beek, dean Faculty of Human Movement Sciences The science behind the klapskate 19.45-20.30 meet, greet & drinks by Extensus Tuesday May 6th 18.00-18.45 Hubertus Irth, dean Faculty of Sciences The Billion-Dollar Molecule - Drug Discovery in the 21st Century 19.00-19.45 Frank van der Duyn Schouten, Rector Magnificus The role of intuition in science 19.45-20.30 meet, greet & drinks by Extensus Tuesday June 3rd 18.00-18.45 Michel ter Hark, dean Faculty of Arts and Faculty of Philosophy Aspect-perception and the role of language 19.00-19.45 Elies van Sliedregt, dean Faculty of Law Should mass murder always be punished? 19.45-20.30 meet, greet & drinks by Extensus The lectures are free of charge and open to all VU, UvA and AUC honours students. You can register yourself for one or more lectures by sending an email to honours@vu.nl Wednesday April 2nd Albert Feilzer, dean Faculty of Dentistry ACTA Safety aspects of jewelry, piercings, cosmetics and biomaterials In daily life people are exposed to a variety of foreign substances. Part of it can be classified as hazardous as exposure to them might result in adverse body reactions. Hazardous substances can be incorporated in food or in the environment, but also in cosmetics, jewelry or body adornments (like tattoos and piercings). Normally, healthy people have an adequate defense system that prevents our body from undesirable adverse reactions to these substances. Nevertheless, as the variety of foreign substances to which one can be exposed has grown enormously during the last decades, we are facing an increased incidence of adverse reactions to foreign materials. Many regulations were developed to prevent unintentional exposure to substances known to cause frequently adverse body reactions. For instance, in Europe new jewelry may not contain nickel anymore, where in the USA it is still permitted. However, in medicine and dentistry medical devices ‘biomaterials’ are applied (e.g. breast implants, dental fillings) that may contain materials that also might affect one’s health. The question is whether the regulations to which medical devices have to abide are more strict or less strict when compared to food or jewelry regulations. In this course a broad overview will be given on potentially dangerous substances to which we can be exposed in relation to laws and regulations that aim to prevent health risks. Albert Feilzer studied dentistry at the University of Amsterdam. After a combined clinical and academic career (1982 to 1998) he became full professor in Dental Materials Science at the Academic Centre of Dentistry Amsterdam (ACTA; UvA & VU). In addition he held the endowed chair of Standardization (2001 to 2007) at the Rotterdam School of Management (EUR). Since June 2009 he is dean of ACTA. Peter Beek, dean Faculty of Human Movement Sciences The science behind the klapskate Although slow in coming, the arrival of the klapskate (klaapschaats) meant a revolution in competitive speed skating. At the Olympic Winter Games of 1998 in Nagano, when the klapskate had just found general acceptance among elite skaters, an avalanche of world records was broken. This was months before the inventor of the klapskate, Gerrit Jan van Ingen Schenau, died from a disease at age 53. The introduction of the klapskate is not only interesting from a sports historical perspective, but also from a scientific point of view. The reason is that it represents a technological innovation in sport that resulted from a thorough fundamental understanding of the biomechanics of what are called explosive stretch chains, which are inherent to activities such as throwing, running and jumping. Van Ingen Schenau recognized that traditional speed skates with fixed irons force skaters to suppress their natural tendency to extend the ankle in order to prevent the tip of the gliding skate from scratching through the ice, thus limiting the contribution of ankle extension to propulsion. Moreover, he attributed a special role to bi-articular muscles (i.e., muscles spanning two joints) in the transfer of power along the stretch chain running from the hip, via the knee, to the ankle, which was effectively aborted by the suppression of ankle extension thus rendering the push-off much less effective. In this course the generic biomechanical theory behind the klapskate will be explained and illustrated using an analog model. It will also be explained how testing this model led to new scientific and technological insights. Peter J. Beek (1959) received a M.Sc. degree (in 1985) and a Ph.D. degree (in 1989) from the Faculty of Human Movement Sciences of VU University Amsterdam, where he became Professor of Coordination Dynamics in 1998 and Dean of Faculty in 2007. His research interests cover a broad range of topics in motor control, including the control of gait posture, bimanual coordination and the perceptual control of movement, as well as skill acquisition in real-life tasks in rehabilitation and sport. He has published extensively on these topics and is editor of the multidisciplinary journal Human Movement Science. Tuesday May 6th Hubertus Irth, dean Faculty of Sciences The Billion-Dollar Molecule - Drug Discovery in the 21st Century The discovery of novel medicines is one of the most costly and scientifically challenging enterprises known to science and industry. From a scientific point of view, it requires a strongly interdisciplinary approach, relying on fundamental insights in chemistry, biology, and in the last decade, on the integration with computational sciences. With development costs in the excess of 1 billion dollar per novel drug and timelines of 10 years and longer, economic considerations en intellectual property aspects also play a major role in successful development strategies. During the course, we will discuss different drug discovery concepts: starting with traditional techniques to isolate medicines from natural resources, we will move on to massive parallel synthetic chemistry as a source of valuable drugs and finally discuss computer-based design. In all instances we will illustrate success and (costly) failure using case studies that also reveal the economic consequences of key decisions made in the in multi-year discovery process. The course requires (very) basic knowledge in chemistry and biology Hubertus Irth studied Environmental Technology at the Technical University of Berlin (1978-1984). He received his PhD in Chemistry at VU University Amsterdam (1989). During his employment as assistant professor at the Leiden/Amsterdam Center for Drug Research, (1990-1999), he started a spin-off biotech company (Screentec, later Kiadis). 1999, he was appointed as full professor at the Department of Chemistry & Pharmaceutical Sciences at VU University. He was director of the department in 2004-2006 and 20092010. In 2010, he was appointed as Dean of the Faculty of Sciences. Since 2014, he is Vice Dean of both the Faculty of Sciences and the Faculty of Earth & Life Sciences. Frank van der Duyn Schouten, Rector Magnificus VU The role of intuition in science In this course we will deal with the question to what extent a scientist can build upon his or her intuition in making conjectures about answers to less trivial questions. We will use some famous paradoxes from probability theory to show that our intuition has its limitations when it comes to guiding us through unknown scientific territory. For this course some basic knowledge of probability theory is a prerequisite. At the end of the course you should have acquired some hesitation about an unconditional confidence in your own intuition, without having lost all confidence in yourself. Two weeks before the course starts the students will receive some questions to think about before coming to the course. Frank van der Duijn Schouten is Professor of Stochastic Operations Research. He is (co)author of some 50 scientific papers on decision making under uncertainty, with applications in business and medicine domains like inventory control, maintenance management, capacity management and group testing. He has been Rector Magnificus of Tilburg University from 1999 to 2008. In May 2013 he was appointed in the same position at the VU. Tuesday June 3rd Michel ter Hark, dean Faculty of Arts and Faculty of Philosophy Aspect-perception and the role of language The sudden sight of something in a completely new light is often called ‘aspect-perception’. A case at hand is when you suddenly notice that your friend’s face now has an aspect of his father’s. Examples of aspect-perception, e.g. ambiguous pictures that can be seen in two ways, are often cited in psychology textbooks under the heading of ‘perceptual illusions’. And as we do with illusions, aspects are explained (away) from a neurophysiological perspective. In this course, we will study aspect-perception from a linguistic perspective. Aspect-perception involves a particular use of language - of concepts. Rather than being an illusion, aspect-perception allows us to feel the need to conceptualize things in a certain way, and thereby to experience the good of making sense of things. In this course, we will discuss examples of aspect-perception drawn from psychology, logic and ethics. At the end of the course you should have acquired some insight in the problem-solving capacities of aspect-perception. No background knowledge in either linguistics or psychology is required. Michel ter Hark has an MA both in psychology and philosophy. He is currently professor of philosophy of language. He is the author of two international monographs and some 40 international papers. He has been Dean of the Faculty of Philosophy from 2000 to 2012. In January 2012 he was appointed as Dean of the Faculty of Arts at VU University, and in 2013 also as Dean of the Faculty of Philosophy. Elies van Sliedregt, dean Faculty of Law Should mass murder always be punished? I will discuss the criminal law defense of duress (overmacht) as a utilitarian theory of justice and focus on the different ways criminal justice systems deal with this defense. Some justice systems (Roman-German) even allow duress to exonerate from liability for murder. Other systems (Anglo-American) never accept it as a defense for murder; it may only mitigate the sentence. The defense of duress will be discussed in the context of the Erdemovic-case, a Bosnian-Serb war criminal who killed 70 Bosnian Muslims. He did not deny the accusation but raised the defense of duress; he could not refuse the order to kill the Drazen Erdemovic at the International Tribunal Muslims. His commander threatened to kill him if he would not pull the trigger. Elies van Sliedregt is Professor of Criminal Law at VU University Amsterdam, Director of the Centre for International Criminal Justice and Dean of the Faculty of Law. She has held visiting fellowships in Cambridge, Oxford, Bologna, and at the University of New South Wales, Sydney. She was a visiting professional with Chambers at the International Criminal Court (ICC) in the Summer of 2010 and fellow-inresidence at the Netherlands Institute for Advanced Studies in the Humanities and Social Sciences for the KNAW (NIAS) in 2011. Van Sliedregt is senior editor of the Leiden Journal of International Law and member of the Royal Holland Society of Sciences and Humanities. Van Sliedregt has published extensively in the field of international, European and comparative criminal law.