Appendix 1: Clinical Inclusion criteria of the THESIS study
Established (History) of Disease


At Risk of Disease or Event
Coronary artery disease: history of stable or

Diabetic nephropathy with microalbuminuria > 30 μg./mL
unstable

Type 1 or 2 diabetes: initially diagnosed by fasting plasma
angina
with
documented
multivessel coronary disease, history of
glucose
multivessel PCI, history of multivessel
currently treated with insulin and/or other hypoglycemic
CABG, history of MI)
agents
Cerebrovascular
ischemic
disease:
stroke,
history
history
of
of
ischemic attack)


transient
> 7 mmol/L on two or more occasions, and
Ankle-arm systolic blood pressure ratio [ankle-brachial
index (ABI)] < 0.9 in either leg at rest

Asymptomatic carotid stenosis
> 70%, established by
Symptomatic Peripheral arterial disease:
angiography or color-coded duplex ultrasound on the basis
intermittent claudiation with history of
of recognized criteria
vascular
angioplasty,
intervention:
reconstructive
amputation,

vascular
Presence of at least one carotid plaque (common carotid
artery, carotid bulb, internal or external carotid arteries)
surgery, atherectomy
evidenced by ultrasonography: defined as a distinct area
with an intima-media thickness (IMT) exceeding twice that
of neighboring sites

Systolic blood pressure > 150mm Hg, despite appropriate
therapy for at least 3 months

Primary hypercholesterolemia: with LDL cholesterol > 160
mg/dL, and / or HDL cholesterol < 35 mg / dL at diagnosis,
whether or not treated
Appendix 2: Medications cost 22-THESIS study
cost per month
Medication class
Drug
(€)
cost per
Medication class
Drug
month (€)
Calcium channel
Antiplatelets
63.36
ISCOVER 75mg
SALOSPIR 100mg
SINTROM 4mg
Anti-coagulants
Nonsteroidal
PLAVIX 75mg
NORVASC 5mg
10.44
39.80
TILDIEM 60mg
11.70
0.60
ZANIDIP 10mg
13.69
VASTAREL 20mg
9.11
PLENDIL 5mg
9.75
ADALAT 30mg CR
10.13
blockers
2.63
anti-
inflammatory
Lipid-lowering agents
XEFO 8mg
11.74
AMLOPEN 10mg
13.74
MESULID 100mg
9.80
LACIPIL 4mg
13.14
CELEBREX 100 mg
7.12
SYSCOR
10mg
6.52
EGIGALM 100 mg
8.52
VOLTAREN 25mg
9.06
LOPRESOR 100mg
3.45
DILATREND 6.25mg
11.42
β-Blockers
ZOCOR 40mg
76.44
CARVEPEN 6.25mg
10.29
VASTATIN 40 mg
62.48
SELECTOL 200mg
9.53
VASSOR 40mg
48.05
LOBIVON 5mg
15.31
SIMVASTATIN 40mg
62.46
KERLONE 20mg
6.31
SIMVACOR 40mg
48.05
INDERAL 40mg
5.88
PRAVOSTIN 40mg
62.49
NEOCARDON 100mg
4.79
NORMOTHERIN 40mg
62.46
PACTENS 10mg
7.48
MAXUDIN 40mg
59.89
LIPITOR 40mg
56.94
LESCΟL 80mg
15.34
LEPUR 40mg
31.23
SUPRANITRIN 2,5mg
14.22
INEGY 10/20
51.87
PANCORAN TTS 5mg
11.62
EZETROL 10mg
51.48
NITRONG TTS 5mg
25.53
EXTRASTATIN 40 mg
62.46
NITROLINGUAL SPRA 0,40 mg
15.61
CRESTOR 20mg
48.30
NITRODYL TTS 5mg
33.57
MONOSORDIL 60mg
13.52
IMDUR 60mg
10.09
EPINITRIL TTS 10mg
12.07
Nitrates
TRINIPATCH TTS
10mg
11.52
Appendix 2 (cont): Medications cost22-THESIS study
cost per
Medication class
month (€)
Drug
cost per
Medication class
month (€)
Drug
Other
Diuretics
LASIX 40 mg
FRUMIL
ACE inhibitors
10.80
antihypertensives
SUPERACE (50+25 mg)
10.68
(40+5
mg)
15.54
PENOPRIL 20mg
11.49
FLUDEX 2.5mg
4.28
OLARTAN PLUS 20mg
24.98
ALDACTONE 25 mg
5.73
LOGIMAX (5+47,5 mg)
36.62
KARVEZIDE 12.5mg
22.39
ZOFEPRIL 15mg
11.27
HYZAAR (50+12,5 mg)
25.13
VEROXIL 20mg
10.06
ENIT (10+20 mg)
24.60
CO-RENITEC
(20+12,5
VASCACE 2,5 mg
9.39
mg)
15.87
TRIATEC 5mg
15.27
CO-DIOVAN 80mg
31.54
CO-DALZAD
TANATRIL 20mg
7.32
160mg+12.5mg
31.54
PRINIVIL 5 mg
7.68
CIBADREX 20mg+25mg
38.70
PRESSURIL 20mg
9.82
ATACAND PLUS
30.47
ENALAPRIL 20mg
DOSTUREL
11.43
ALDOMET 250 mg
4.83
TARONTAL 400mg
12.99
(50+25
mg)
9.68
Claudication
Angiotensin
COVERSYL 5mg
12.58
CAPOTEN 50mg
6.45
LOFTYL 600mg
16.28
ACCUPRON 20mg
12.78
DAFLON 500
12.54
PRITOR 80mg
24.64
PROTAPHANE
58.06
OLMETEC 10mg
18.51
MIXTARD 30mg
58.06
OLARTAN 10mg
18.51
HUMULIN M3
59.32
MICARDIS 80mg
24.64
ACTRAPID
58.06
LOSADRAC 50mg
15.80
KARVEA
33.94
Biguanides
GLUCOPHAGE 850mg
7.02
Sulfonylureas
SOLOSA 4mg
11.30
NOVONORM 1mg
11.08
AVANDIA 8mg
24.33
medications
II–
receptor
antagonists
75 mg
DIOVAN 80mg
25.02
COZAAR 50mg
18.34
ATACAND 8mg
18.45
APROVEL 300mg
26.65
Insulin
Thiazolidinediones
Other
ZOFEPRIL
PLUS
antihypertensives
(30+12,5 mg)
11.27
VASTAREL 20mg
9.11
VASCACE PLUS
9.40
TRIATEC PLUS 5+25
mg
TIADEN
15.30
(50+5mg)
TEVETEN
4.12
PLUS
600+12,5 mg
23.86
TENORETIC 50mg
5.78
ACTOS
Other antidiabetics
15mg
33.21
STARLIX 60mg
38.60
Appendix 3: Hospitalization, outpatient visits, vascular interventions and laboratory and imaging diagnostic test costs – THESIS study
Cost per item (€)
Laboratory and imaging diagnostic tests
Hospitalization
(without
management
of
Cost per day (€)
implications)
Computed tomography scans
70
In clinic of public hospital
320
Magnetic resonance imaging (MRI)
250
In clinic of private hospital
650
Ultrasound
30
In Intensive Care Unit of public hospital
555
Thallium scintigraphy
250
In Intensive Care Unit of private hospital
1200
Triplex
30
Rehabilitation center
180
Echocardiography
30
Digital subtraction angiography (DSA)
250
Management
of
complications
hospitalization
during
Cost per complication
(€)
Magnetic resonance angiography (MRA)
250
Stroke
1300
Blood and biochemistry tests
50
Myocardial infarction
1125
Heart failure
561
Arrythmia
1900
5000
Other cardiovascular events
1200
7000
Death
1200
Bleeding
1200
Thrombosis
2050
Cost per item (€)
Vascular interventions
Angiography
Percutaneous
250
transluminal
coronary
angioplasty
(PTCA)/stenting
Coronary artery bypass graft (CABG) surgery
Other vascular surgery
3500-6500
Pacemaker implantation
temporary implantation
2500
permanent implantation
Outpatient visits to
Hospital outpatient department
Hospital accident and emergency department
5000
Cost per visit (€)
20
20
General practitioner
40
Other healthcare professionals (i.e. physiotherapists)
40
Respiratory infections
1600
UTI
850
Appendix 4
List of investigators and centres
Steering Committee: Prof. N. Maniadakis, Prof. J. Kyriopoulos, Prof. E. Bastounis, Prof. D.
Kokkinos, Prof. D. Vasilopoulos.
Main Investigators by participating center
1. University General Hospital of Heraklion in Crete (South): Prof. P. Vardas
2. University General Hospital of Patras in Peloponnesus (South West): Prof. I. Tsolakis
3. General Hospital of Thessalonica “Papageorgiou” (North): Dr. G. Roudolf
4. University General Hospital of Thessalonica “AHEPA” (North): Dr. S. Gavriilides
5. General Hospital of Athens “Euangelismos” (Centre): Dr. A. Manolis
6. General Hospital of Athens “Attikon” (Centre): Dr. S. Vasdekis
7. General Hospital of Athens “Alexandra” (Centre): Dr. K. Vemmos
8. Cardiosurgery Center “Onasseio” (Centre): Prof. D. Kokkinos
9. General Hospital of Athens “Agia Olga-Konstantopouleio” (Centre): Dr. E. Varsamis
10. General Hospital of Athens “Georgios Gennimatas” (Centre): Dr. K. Karageorgiou
11. General Hospital of Athens “Erythros Stauros” (Centre): Dr. V. Andrikopoulos