Publicaciones 2009
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Publicaciones SICI 2010
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Afonso-Oramas D, C.-M. I., Barroso-Chinea P, Álvarez de la Rosa D, Castro-Hernández J,
Salas-Hernández J, Giráldez T, González-Hernández T. The dopamine transporter is
differentially regulated after dopaminergic lesion. Neurobiol Dis 40, 518-530 (2010).
Agnati LF, G. D., Vilardaga JP, Ciruela F, Fuxe K. On the expanding terminology in the
GPCR field: the meaning of receptor mosaics and receptor heteromers. J Recept Signal
Transduct Res. 30, 287-303 (2010).
Agnati LF, G. D., Albertin G, Trivello E, Ciruela F, Genedani S, Tarakanov A, Fuxe K. An
integrated view on the role of receptor mosaics at perisynaptic level: focus on
adenosine A(2A), dopamine D(2), cannabinoid CB(1), and metabotropic glutamate
mGlu(5) receptors. J Recept Signal Transduct Res. 30, 355-369 (2010).
Aldea M, C., M., Mulet, J., Sala, S., Criado, M., Sala, F. Role of the extracellular
transmembrane domain interface in gating and pharmacology of a heteromeric
neuronal nicotinic receptor. J. Neurochem. 113, 1036-1045 (2010).
Alexander J., S., D., Krivoshein, A., Criado, M., Jefford, G., Green, W. Ric-3 promotes
7 nicotinic receptor assembly and trafficking through the ER sub-compartment of
dendrites. J. Neurosci 30, 10112-10126 (2010).
Arora D, H. D., Kourrich S, Pravetoni M, Fernández-Alacid L, Nicolau JC, Luján R,
Wickman K. Altered neurotransmission in the mesolimbic reward system of Girk mice.
. J Neurochem. 114, 1487-1497 (2010).
Bielanska J., H.-L., J., Moline, T., Somoza, R., Ramón Y Cajal, S., Condom, E., Ferreres,
JC., Felipe, A. Voltage-dependent potassium channels Kv1.3 and Kv1.5 in human fetus.
Cell Physiol Biochem 26, 219-226 (2010).
Borroto-Escuela DO, C. P., Perez Alea M, Narvaez M, Garriga P, Fuxe K, Ciruela F.
Impaired M(3) muscarinic acetylcholine receptor signal transduction through blockade
of binding of multiple proteins to its third intracellular loop. Cell Physiol Biochem. 25,
397-408 (2010).
Borroto-Escuela DO, G.-N. G., Garriga P, Fuxe K, Ciruela F. The M(5) muscarinic
acetylcholine receptor third intracellular loop regulates receptor function and
oligomerization. Biochim Biophys Acta - Molecular Cell Research 1803, 813-825.
(2010).
Borroto-Escuela DO, M., D., Narvaez, M., Flajolet, M., Heintz, N., Agnati, L., Ciruela, F.,
Fuxe, K. . A serine point mutation in the adenosine A2AR C-terminal tail reduces
receptor heteromerization and allosteric modulation of the dopamine D2R.
Biochemical and Biophysical Research Communications 394, 222-227 (2010).
Borroto-Escuela DO, R.-F. W., Tarakanov AO, Marcellino D, Ciruela F, Agnati LF, Fuxe K.
Dopamine D2 and 5-hydroxytryptamine 5-HT(₂A) receptors assemble into functionally
interacting heteromers. Biochem Biophys Res Commun. 401, 605-610 (2010).
Borroto-Escuela DO, R.-F. W., Tarakanov AO, Gómez-Soler M, Corrales F, Marcellino D,
Narvaez M, Frankowska M, Flajolet M, Heintz N, Agnati LF, Ciruela F, Fuxe K.
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Characterization of the A2AR-D2R interface: focus on the role of the C-terminal tail and
the transmembrane helices. Biochem Biophys Res Commun. 402, 801-807 (2010).
Brown MT, B. C., Mameli M, Labouèbe G, Bocklisch C, Balland B, Dahan L, Luján R,
Deisseroth K, Lüscher C. Drug-driven AMPA receptor redistribution mimicked by
selective dopamine neuron stimulation. PLoS One 5, :e15870. (2010).
Burzomato V, F., G., Pérez-Otaño, I., Kittler, J., Attwell, D. The receptor subunits
generating NMDA receptor mediated currents in oligodendrocytes. Journal of
Physiology 15, 3403-3414 (2010).
Carrasquero LM, D., EG., Sánchez-Ruiloba, L., Iglesias, T., Miras-Portugal, MT.
Mechanisms of protein kinase D activation in response to P2Y(2) and P2X7 receptors in
primary astrocytes. Glia. 58, 984-995 (2010).
Ciruela F, A. C., Soriano A, Cuffí L, Carbonell L, Sánchez S, Gandía J, Fernández-Dueñas
V. Adenosine receptors interacting proteins (ARIPs): Behind the biology of adenosine
signaling. Biochim Biophys Acta. 1798, 9-20 (2010).
Ciruela F, F.-D. V., Sahlholm K, Fernández-Alacid L, Nicolau JC, Watanabe M, Luján R.
Evidence for oligomerization between GABAB receptors and GIRK channels containing
the GIRK1 and GIRK3 subunits. Eur J Neurosci. 32, 1265-1277, doi:doi: 10.1111/j.14609568.2010.07356.x (2010).
Ciruela F, V. A., Arnau JM, Sánchez S, Borroto-Escuela DO, Agnati LF, Fuxe K,
Fernández-Dueñas V. G protein-coupled receptor oligomerization for what? J Recept
Signal Transduct Res. 30, 322-330 (2010).
Ciruela F, V. J., Fernández-Dueñas V. Lighting up multiprotein complexes: lessons from
GPCR oligomerization. Trends Biotechnol. 28, 407-415 (2010).
Colomer C, O.-O., LA., Vincent, A., McIntosh, JM., Artalejo, AR., Guérineau, NC.
Functional characterization of alpha9-containing cholinergic nicotinic receptors in the
rat adrenal medulla: implication in stress-induced functional plasticity. J. Neurosci 30,
6732-6742 (2010).
Criado M, C., M., Mulet, J., Sala, F., Sala, S. Role of loop 9 on the function of neuronal
nicotinic receptors. Biochim. Biophys. Acta Biomembranes 1798, 654-659 (2010).
Criado M, M., J., Castillo, M., Gerber, S., Sala, S., Sala, F. The loop between betastrands beta 2 and beta 3 and its interaction with the N-terminal alpha-helix is
essential for biogenesis of alpha 7 nicotinic receptors. J. Neurochem 112, 103-111
(2010).
ElMlili N, B., J., Ahabrach, H., Rodrigo, R., Errami, M. and Felipo, V. Chronic
hyperammonemia induces tonic activation of NMDA receptors in cerebellum. J
Neurochem 1005-1014 (2010).
Erceg S, R. M., Zipancic I, Lainez S, Roselló MG, Xiong C, Moreno-Manzano V,
Rodríguez-Jiménez FJ, Planells R, Alvarez-Dolado M, Bhattacharya SS, Stojkovic M.
Efficient differentiation of human embryonic stem cells into functional cerebellar-like
cells. Stem Cells Dev. 19, 1745-1756 (2010).
Espada S, O., F., Molina-Jijón, E., Rojo, AI., Pérez-Sen, R., Pedraza-Chaverri, J., MirasPortugal, MT., Cuadrado, A. The purinergic P2Y(13) receptor activates the Nrf2/HO-1
axis and protects against oxidative stress-induced neuronal death. Free Radic Biol Med
49, 416-426 (2010).
Fernández-Dueñas V, C. F., Gandía J, Sánchez S, Planas E, Poveda R. Histamine H3
receptor activation potentiates peripheral opioid-mediated antinociception: substance
P role in peripheral inflammation in mice. Eur J Pharmacol. 638, 72-77 (2010).
Fuxe K, M. D., Borroto-Escuela DO, Guescini M, Fernández-Dueñas V, Tanganelli S,
Rivera A, Ciruela F, Agnati LF. Adenosine-dopamine interactions in the pathophysiology
and treatment of CNS disorders. CNS Neurosci Ther. 16, e18-42 (2010).
Fuxe K, M. D., Borroto-Escuela DO, Frankowska M, Ferraro L, Guidolin D, Ciruela F,
Agnati LF. The changing world of G protein-coupled receptors: from monomers to
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dimers and receptor mosaics with allosteric receptor-receptor interactions. J Recept
Signal Transduct Res. 30, 272-283 (2010).
Gómez-Pinedo U, R., R., Cauli, O., Herraiz, S., Garcia-Verdugo, JM., Pellicer, B., Pellicer,
A., and Felipo, V. cGMP modulates stem cells differentiation to neurons in brain in
vivo. Neuroscience 165, 1275-1283 (2010).
Gomez-Posada JC, E., A., Roura-Ferrer, M., Areso, P., Masin, M., Murrell-Laganado,
R.D.,Villarroel, A. A pore residue of the KCNQ3 potassium M-channel subunit controls
surface expression. J. Neurosci, 309361-309323 (2010).
Henson MA, R. A., Pérez-Otaño I, Philpot BD. Influence of the NR3A subunit on NMDA
receptor functions. Prog Neurobiol. 91, 23-37 (2010).
Hernández-Díaz I, G. T., Arnau MR, Smits VA, Jaisser F, Farman N, Alvarez de la Rosa D.
The mineralocorticoid receptor is a constitutive nuclear factor in cardiomyocytes due
to hyperactive nuclear localization signals. Endocrinology. 151, 3888-3899 (2010).
Laínez S, V., P., Ontoria-Oviedo, I., Estevez-Herrera, J, Camprubí-Robles, M., FerrerMontiel, A. and Planells-Cases R. GABAA receptor-associated protein (GABARAP)
modulates TRPV1 expression and channel activity FASEB J, 1958-1970 (2010).
Lin MT, L., R., Watanabe, M., Frerking, M., Maylie, J., Adelman, JP. . Coupled activitydependent trafficking of synaptic SK2 channels and AMPA receptors. J Neurosci Res 30,
11726-11734 (2010).
Llansola M, F., V. Metabotropic glutamate receptor 5, but not 1, modulates NMDA
receptor-mediated activation of neuronal nitric oxide synthase. Neurochem. Int. 56,
535-545 (2010).
Llansola M, M. C., Boix J, Felipo V. Polychlorinated biphenyls PCB 52, PCB 180, and PCB
138 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture
by different mechanisms. Chem Res Toxicol 23, 813-820 (2010).
Lucas M, E. J., Arribas EA, Oyenarte I, García IG, Kortazar D, Fernández JA, Mato JM,
Martínez-Chantar ML, Martínez-Cruz LA. Binding of S-methyl-5'-thioadenosine and Sadenosyl-L-methionine to protein MJ0100 triggers an open-to-closed conformational
change in its CBS motif pair. J Mol Biol 396, 800-820 (2010).
Luján R. Organisation of potassium channels on the neuronal surface. J Chem
Neuroanat 40, 1-20 (2010).
Martín R, D. T., Ciruela F, Torres M, Pin JP, Sánchez-Prieto J. The metabotropic
glutamate receptor mGlu7 activates phospholipase C, translocates munc-13-1 protein,
and potentiates glutamate release at cerebrocortical nerve terminals. J Biol Chem. 285,
17907-17917 (2010).
Martinez-Pinna J, G. I., Mahaut-Smith MP, Morales A. Direct voltage control of
endogenous lysophosphatidic acid G-protein-coupled receptors in Xenopus oocytes. J
Physiol. 588 (pt 10), 1683-1693 (2010).
Monfort P, F., V. Amyloid impairs and ibuprofen restores the cGMP pathway,
synaptic expression of AMPA receptors and long-term potentiation in hippocampus. J
Alz Dis 22(3), 795-809 (2010).
Montoliu C, R. R., Monfort P, Llansola M, Cauli O, Boix J, Elmlili N, Agusti A, Felipo V.
Cyclic GMP pathways in hepatic encephalopathy. Neurological and therapeutic
implications. Metab Brain Dis. 25, 39-48 (2010).
Nassirpour R., B., L., Lalive, AL., Lüscher, C., Luján, R., Slesinger, PA. Morphine- and
CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons. J
Neurosci 30, 13419-13430 (2010).
Olivera-Bravo S, I., I., Morales, A. Differential effects of quaternary ammonium
anticholinesterases on microtransplanted neuroeceptors: selective modulation of
nicotinic receptor function. Journal of Molecular Neuroscience 40, 250-252 (2010).
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Ortega F, P.-S., R, Morente, V, Delicado, EG, Miras-Portugal, MT. P2X7, NMDA and
BDNF receptors converge on GSK3 phosphorylation and cooperate to promote survival
in cerebellar granule neurons. Cell. Mol. Life Sci. 67, 1723-1733. (2010).
Pérez de Vega MJ, G.-L., MT., Zaccaro, L., Royo, M., Albericio, F., Fernández-Carvajal,
A., Ferrer-Montiel, A. González-Muñiz, R. . Solid-Phase Synthesis of New Trp(Nps)Containing Dipeptide Derivatives as TRPV1 Channel Blockers. Molecules 15, 4924-4933
(2010).
Renart ML, T., I., Poveda, JA., Encinar, JA., Fernández, AM., Ferrer-Montiel, AV.,
Gómez, J., González Ros, JM. . Ion Binding to KcsA: Implications in Ion Selectivity and
Channel Gating. Biochemistry 49, 9480-9487 (2010).
Ricobaraza A, C.-T. M., Marco S, Pérez-Otaño I, García-Osta A. Phenylbutyrate rescues
dendritic spine loss associated with memory deficits in a mouse model of Alzheimer
disease. Hippocampus. 2010 Nov 10. [Epub ahead of print] (2010).
Rodrigo R, C., O., Gomez-Pinedo, U., Agusti, A., Hernandez-Rabaza, V., Garcia-Verdugo,
JM and Felipo, V. Hyperammonemia induces neuroinflammation that contributes to
cognitive impairment in rats with hepatic encephalopathy. Gastroenterology 139, 675684 (2010).
Roura-Ferrer M, S., L., Oliveras, A., Dahan, R., Bielanska, J., Villarroel, A., Comes, N.,
Felipe, A. Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface
targeting. J Cell Physiol 225, 692-700 (2010).
Solé L, F., A. Does a physiological role for KCNE subunits exist in the immune system? .
Commun Integr Biol 3, 166-168 (2010).
Triano I, B., FN., Renart, ML., Molina, ML., Fernández-Ballester, G., Poveda, JA.,
Fernández, AM., Encinar, JA., Ferrer-Montiel, AV., Otzen, D., González-Ros, JM. .
Occupancy of nonannular lipid binding sites on KcsA greatly increases the stability of
the tetrameric protein. Biochemistry 49, 5397-5404 (2010).
Vilardaga JP, A. L., Fuxe K, Ciruela F. G-protein-coupled receptor heteromer dynamics. J
Cell Sci. 123, 4215-4220 (2010).
Villalonga N, D., M., Bielanska, J., Vicente, R., Comes, N., Valenzuela, C., Felipe, A.
Immunomodulation of voltage-dependent K+ channels in macrophages: molecular and
biophysical consequences. J Gen Physiol. 135, 135-147 (2010).
Villalonga N, D., M., Bielańska, J., González, T., Parra, D., Soler, C., Comes, N.,
Valenzuela, C., Felipe, A. Immunomodulatory effects of diclofenac in leukocytes
through the targeting of Kv1.3 voltage-dependent potassium channels Biochem
Pharmacol 80, 858-866 (2010).
Wesch D, M., P., Afonso-Oramas, D., Althaus, M., Castro-Hernandez, J., Dominguez, J.,
Morty, RE., Clauss, W., Gonzalez-Hernandez, T., Alvarez de la Rosa, D., Giraldez, T. The
neuronal-specific SGK1.1 kinase regulates δ epithelial Na+ channel independently of PY
motifs and couples it to phospholipase C signaling. American Journal of Physiology: Cell
Physiology 299, C779-C790 (2010).