Dietary fiber intake modulates the genetic effects on serum lipid levels and insulin resistance in
Korean genome-wide association study
Hye-Ja Lee1, Ju Yeon Park1, Yun Kyoung Kim2, Han Byeol Jang1, Joo-Yeon Hwang2, Bok-Ghee
Han2, and Jihyun Song1
1
Division of Metabolic Diseases, Center for Biomedical Sciences, National Institute of Health, Cheongwon-gun,
Chungcheongbuk-do, Korea.
2
Center for Genome Science, National Institute of Health, Cheongwon-gun, Chungcheongbuk-do, Korea.
Serum lipid concentrations are the key risk factors for the insulin resistance and associated with coronary
artery disease (CAD). Genetic influence with heritability and lifestyle factors explain serum level of
cholesterols, triglycerides, and HOMA-IR. To explore genetic loci interaction with dietary fiber intake
participating in serum lipid level, we analyzed Korean genome-wide genotype data and dietary fiber intake
from the KARE project (n = 7495). Among them, we investigated genome-wide significant signals newly
interacting with dietary fiber intake explaining their potential involvement in HOMA-IR. After the adjustment
with age, sex, recruitment area, and BMI, rs651007 of ABO gene compelled the significant association with
serum cholesterol levels as well as LDL cholesterol level and modulated them interacting with dietary fiber
intake. The rs765547, rs17411126, rs1919484, and rs1837842 in LPL loci showed the significant association
with LDL cholesterol levels and also interacted with dietary fiber intake. MYL2-CCDC63 loci showed the
significant association with serum HDL cholesterol levels and also interacted with dietary fiber intake. In
serum TG and HDL cholesterol levels, C12orf51 gene polymorphisms showed the highest significance in the
additive model for the interaction. Rs10942739 in COL4A3BP, rs4045166, rs6861279 and rs34340 in
LOC728780 gene, rs648443 in ODZ4, and rs7320766 in GPC5 gene affected serum TG level interacting with
fiber intake. Moreover, rs648443 in ODZ4, and rs7320766 in GPC5 gene were associated with insulin
resistance and rs648443 in ODZ4 interacted with dietary fiber intake to modulate the insulin resistance.
Conclusion: This result suggests the overall understanding of genetic and environmental information is needed
to prevent the dyslipidemia and insulin resistance.
Keywords: genome-wide interaction, dietary fiber intake, lipids, Korean
1