Table S1: Genotype D strains with mutations in the reverse transcriptase domain that may lead to drug resistance
HBV reverse transcriptase domain
Codon
173
180
181
184
191
194
202
204
207
213
214
215
233
236
V
L
A
T
V
A
S
M
V
S
V
Q /P/H
I
N
GU456682
.
.
.
.
.
V
.
.
.
.
.
S
.
.
GU456646
.
.
.
.
.
.
.
.
.
.
.
.
V
.
GU456638
M
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
S
.
.
GU456645
.
.
.
.
.
.
.
.
.
.
.
S
.
.
GU456639
.
.
.
.
.
.
.
.
M
.
E
.
.
.
GU456637
.
.
.
.
.
.
.
.
.
T
.
.
.
.
JF754633
.
.
.
.
.
.
.
.
.
T
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
S
.
.
.
.
.
.
.
.
.
.
.
.
A
S
.
.
Subgenotype Accession numbers
GU456647
Country
Iran
D1
JF754631
JF754629
Turkey
JF754623
.
.
.
.
.
.
.
.
.
T
.
.
.
.
JF754619
.
.
.
.
.
.
.
.
.
.
.
S
.
.
JF754599
.
.
.
.
.
.
.
.
.
T
.
.
.
.
JF754614
.
.
.
.
.
.
.
.
.
T
.
.
.
.
JF754598
.
.
.
.
.
.
.
.
.
T
.
.
.
.
FJ904431
.
.
.
.
.
.
.
.
.
.
.
S
.
.
FJ904446
.
.
.
.
.
.
.
.
.
T
.
.
.
.
JN642155
.
.
.
.
I
.
.
.
.
.
.
.
.
.
JN642153
.
.
.
.
.
.
.
.
.
.
.
S
.
.
JN642149
.
.
.
.
.
.
.
.
.
T
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
S
.
.
JN642137
.
.
.
.
.
.
.
.
.
.
E
.
.
.
JN642129
.
.
.
.
.
.
.
.
.
.
E
.
.
.
JN642158
.
.
.
.
.
.
.
.
M
.
.
.
.
.
JN642154
.
.
.
.
.
.
.
.
.
T
.
.
.
.
Tunisia
JN642145
Lebanon
JN642150
.
.
.
.
.
.
.
.
.
.
.
S
.
.
JN642140
.
.
.
.
.
.
.
.
.
.
G
.
.
.
.
.
.
.
.
.
.
.
.
T
.
.
.
.
M
.
.
.
.
.
.
.
.
.
.
.
.
.
AF121242
Sweden
GQ477453
Poland
EU594398
Russia
.
.
.
.
.
.
.
.
.
.
.
S
.
.
JN642163
Lebanon
.
.
.
.
.
T
.
.
.
T
.
.
.
.
AF043594
Germany
.
.
.
.
.
.
.
.
.
.
.
S
.
.
AB109478
Japan
.
.
.
.
.
.
.
.
.
T
.
.
.
.
X80925
UK
.
.
.
.
.
.
T
.
.
.
.
.
.
.
GQ922003
Canada
.
.
.
.
.
.
.
.
.
.
.
.
V
.
FJ904441
.
.
.
.
.
.
.
.
.
.
E
.
.
.
FJ904433
.
.
.
.
.
.
.
.
.
.
I
.
.
.
.
.
.
.
.
.
.
.
.
.
A
.
.
.
FJ904430
.
.
.
.
.
.
.
.
.
.
E
.
.
.
FJ904414
.
.
.
.
.
.
.
.
.
.
.
S
.
.
D2
D4
D7
FJ904395
Tunisia
D6
FJ904404
.
.
.
.
.
.
.
.
.
T
D
.
.
.
AB493848
.
.
.
.
.
.
.
.
.
.
.
S
.
.
.
.
.
.
.
.
.
.
.
.
.
S
.
.
.
.
.
A
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
T
.
.
.
.
.
.
.
.
AB493845
Papua
AB554024
D8
FN594769
Niger
Dots indicate amino acids identity and the mutations are highlighted in grey. Only sequences, which had mutations, are shown. All other
sequences were wild-type.
Table S2: Genotype D strains with mutations in the HBsAg that may lead to vaccine, detection and/or immune escape
HBsAg
Subgenotype
D1
D2
Accession numbers
Country
120
133
144
145
153
158
P
M
D
G
P
F
GU456682
Iran
.
.
.
.
.
L
FJ904427
Tunisia
.
.
E
R
.
.
JN642133
.
S
.
.
.
.
JN642166
S
.
.
.
.
.
JN642134
Lebanon
T
.
.
.
.
.
AF151735
Germany
.
.
E
.
.
.
AY945307
India
.
.
.
.
.
L
EU594433
Russia
T
.
.
.
.
.
.
.
.
E
.
.
GQ205389
D5
D8
GQ205385
India
.
.
.
E
.
.
FN594770
Niger
.
T
.
.
.
.
Dots indicate amino acids identity and the mutations are highlighted in grey. Only sequences, which had mutations, are shown. All other
sequences were wild-type.