Appendix A. Supplementary information for Table 1, including the cost calculation for hospitalization and dialysis access. Appendix Table A1 Hospital costs per day for manuscript table 1 Type State/Local Non-Profit For-Profit Government Hospitals Hospitals Hospitals Cost1 $1,667 $2,088 $1,628 2 Percentage 21% 58% 21% Weighted Average Single Day $1,902 Cost (2009 $) Cost Per Day in 2013 $ for the $2,024 Model3 1. From Kaiser foundation web page on adjusted expenses per inpatient day.(20) 2. From the American Hospital Association, Fast Facts on US Hospitals.(19) 3. Inflation from the medical consumer price index information for Urban locations from the Bureau of Labor Statistics.(18) Appendix Table A2 Access costs in detail for manuscript table 1 Subtype Distribution Costs Weighted (%) costs PD access Laproscopy 50% $2,716 $2,492.30 Percutaneous1 50% $2,268 Temporary Femoral + 34% $2,784.62 HD access Cuffed catheter2 Uncuffed + 22% $2,784.62 $2,437.09 Cuffed catheter2 Cuffed 44% $1,994.68 catheter2 HD AVF 61% $3,099.95 permanent AVG $2,789.96 39% $3,099.95 3 access Dual4 Initial Femoral 61% $789.84 $789.84+ Initial Uncuffed 39% $789.84 $2,492.30 PD 100% $2,492.30 1. CMS costs by CPT codes as follows for Laproscopy, Percutaneous: 49421, 49324.(21) 2. CMS costs by CPT codes as follows for femoral, uncuffed, cuffed: 36556 36558, 36563.(21) 3. Assumes 90% of HD patients receive the permanent access surgery within 90 days based on Gomes.(22) 4. CMS costs by CPT code 36556.(21) Appendix B. Supplementary information for Table 2, including detailed information for facility costs, personnel, supplies, lab, and medications. Appendix Table B1 Facility costs for manuscript table 2 subtype Months1 PD Costs per patient month2 $445 $123 $445 $445 $445 $123 In-clinic PD 0.5 Home PD 2.5 HD HD 3 Dual ICHD Days 0-2 0.067 ICPD Days 3-16 0.5 Home PD Days 2.5 17-90 1. Number of month estimates from the survey. 2. Costs per patient month from Hornberger 2012 Table 1.(4) Total costs $530.00 $1,335.00 $559.67 Appendix Table B2a Personnel costs (salary) for PD for manuscript table 2 Total PD personnel cost $2,210.25 $3,157.50 Days 0-90 minutes Cost per Total Salary Total minute Costs1 Medical Director fee2 $90 $128.57 Nurse 3660 $0.54 $1,992.26 $2,846.09 Dietician 50 $0.45 $22.50 $32.14 Social worker 180 $0.41 $74.22 $106.03 Financial coordinator 45 $0.54 $24.17 $34.53 Clinic manager 10 $0.71 $7.11 $10.16 1. Based on mean hourly wages, adjusted to reflect costs of benefits (30%), from the US Bureau of Labor Statistics and survey responses for time all converted to minutes.(23,24) 2. Medical Director Fee from expert opinion. 3. For dual patients, the personnel costs include all the costs for urgent-start PD plus 2 hours technician time and 40 minutes nurse time. As a result, the total estimated salary cost is $2,568.99. Appendix Table B2b Personnel costs for HD for manuscript table 2 Total HD Personnel Days $1,541.11 $2201.58 Cost1 minutes Cost per Total Salary Total Cost minute Medical Director fee2 $90 $128.57 Technician 2340 $0.36 $832.65 $1,189.50 Nurse 780 $0.54 $424.58 $606.54 Dietician 50 $0.45 $22.50 $32.14 Social worker 195 $0.41 $80.41 $114.87 Machine Tech 195 $0.31 $59.70 $85.29 Financial coordinator 45 $0.54 $24.17 $34.53 Clinic manager 10 $0.71 $7.11 $10.16 1. Based on mean hourly wages, adjusted to reflect costs of benefits (30%), from the US Bureau of Labor Statistics and survey responses for time all converted to minutes.(23,24) 2. Medical Director Fee from expert opinion Appendix Table B3a PD Supply costs for days 0-14 for manuscript table 2 Total PD supplies cost days 0-14 $270.40 1 Units Unit cost Total cost 2 Machine 0.5 months $250.00 $1252 3 Reclining chair 0.5 months $1,121.43 $4.303 PD solution 1.5% 6L 6 $10.004 $60.00 4 Integrated APD set (including 6 $12.00 $72.00 cassette, tubing, and drain bag) Minicap 6 $0.354 $2.10 4 Other (including dressings and 14 $0.50 $7.00 gloves) 1. Estimates from the survey. 2. Based on monthly rent over 2 weeks, the rent itself was based on internal estimates from Baxter. 3. Based on 5 year life of chair, $1,121.43 cost from the FMC catalog, and zero resale value using discounted annuitization with a 3% annual rate then converted to weekly costs (FMC Catalog for prices, Hornberger for time horizon).(4, 25) 4. Supply costs based on internal Baxter estimates of average sales prices to dialysis clinics. Appendix Table B3b PD Supply costs for days 15-90 for manuscript table 2 Total home services and supplies cost $2,706.10 Units Unit cost Total cost 1 Home Cycler rent for 2.5 months 2.5 months $99.00 $ 247.50 1 PD solutions (2 bags/day) 152 $10.00 $1520.00 Integrated APD set (including cassette, 76 $12.001 $912 tubing, and drain bag) Minicap 76 $0.351 $26.60 1. Supply costs based on internal Baxter estimates of average sales prices to dialysis clinics. Appendix Table B3c HD Supply costs for 90 days for manuscript table 2 Total HD supplies cost $1399.86 Units unit cost total cost Machine & maintenance 39 $11,5001 $164.121 Dialysis chair 39 $1121.432 $15.302 1 Water treatment system & 39 $110,000 $85.541 maintenance (24 stations) Dialyzer 39 $11.003 $4293 Dialysis needles (0.40)*2 78 $0.403 $31.23 Dialysis blood set 39 $3.003 $337.633 3 Saline 78 $1.25 $39.043 Heparin (5000 units/session) 39 $6.303 $245.703 Dialysate (Bicarbonate + Acid) 39 $4.003 $156.003 (central supply) Other, including dialysis 39 $1.003 $39.003 syringes, gloves, and dressings 1. Supply costs based on internal Baxter estimates of average sales prices to dialysis clinics, time horizons from Hornberger and using a 3% rate to annuitize the costs. Further, maintenance costs of $1.25 per patient per session costs were included for both the dialysis machine and and the water treatment system. Annuitized costs used 7 years for the dialysis machine and 9 years for the water treatment system from Hornberger.(4) Also assumed that the water treatment system could treat 80 patients based on Hornberger and that the machine could treat 6 patients per week.(4) 2. Based on 5 year life of chair, $1,121.43 cost from the FMC catalog, and zero resale value using undiscounted annuitization with a 3% annual rate then converted to weekly costs (FMC Catalog for prices, Hornberger for time horizon).(4, 25) 3. Supply costs based on internal Baxter estimates of average sales prices to dialysis clinics. Appendix Table B3d Dual patient supply costs for manuscript table 2 Total dual patients cost per patient $2,977.08 Total cost per session type HD Supply Costs Days 0-2 $71.791 In Center PD supply costs days 3-16 $270.402 Home PD Cost days 17-90 $2,634.893 1. Dual patient costs are HD costs for 2 sessions followed by PD costs. These costs are the same as those for HD but scaled to 2 sessions. 2. These are the same as for PD in days 0-14 but they reflect days 2-16. 3. These are the same as for PD in days 15-90 except the total is adjusted to reflect 74 days rather than 76 because HD takes up the first two days of the 90 day period (2,634.89 = 2,706.10*(74/76)). Appendix Table B4 Lab costs for manuscript table 2 Urgent-start HD Urgent-start PD 2 Unit Units Total cost Units2 Total cost cost1 CBC $10.69 3 $32.07 3 $32.07 Hgb $3.26 6 $19.56 3 $9.78 CHEM 7§ $11.63 3 $34.89 3 $34.89 Albumin $0.00 3 $0.00 3 $0.00 Calcium $7.09 3 $21.27 3 $21.27 Phosphorus $6.52 3 $19.56 3 $19.56 Alkaline $7.11 3 $21.33 3 $21.33 Phosphatase Magnesium $9.21 1 $9.21 1 $9.21 Aluminum $35.02 1 $35.02 1 $35.02 Iron Profile $8.90 3 $26.70 3 $26.70 Ferritin $18.73 1 $18.73 1 $18.73 Lipid Panel $0.00 1 $0.00 1 $0.00 PTH Intact $56.74 1 $56.74 1 $56.74 TSH $23.10 1 $23.10 1 $23.10 25-OH Vit D $40.70 1 $40.70 1 $40.70 HgbA1C $13.34 1 $13.34 1 $13.34 HBsAG $14.20 1 $14.20 1 $14.20 HBsAb $14.76 1 $14.76 1 $14.76 HBcAb $16.57 1 $16.57 1 $16.57 Hep C $19.62 0 $0.00 0 $0.00 TB (2-Stage $85.20 1 $85.20 1 $85.20 Test) Total Lab Cost $502.95 $493.17 1. Costs by CPT code from the National Fee Analyzer.(26) 2. Frequency from the survey. 3. For dual patients, the lab costs include the costs for urgent-start PD plus one additional CBC test and another CHEM 7§ test. As a result, the total lab test costs equal $515.49. Appendix Table B5 Medication costs for manuscript table 2 HD (90 days) % use erythropoietin (EPO)1 Iron Sucrose (Venofer) Doxercalcifero l (Hectorol) Calcitriol (Calcijex) Recombinant tissue plasminogen activator (rTPA) Total Medication Cost Total dose1 Unit cost PD (90 days) Total costs % use Total dose Unit cost Total costs 90 220000 $0.01 $2,172.85 50 108000 $0.01 $592.60 80 1200 $0.34 $321.60 67 375 $0.34 $84.17 60 90 $1.85 $99.68 0 1 72 $3.61 $2.60 0 10 2 $84.02 $16.80 0 $2,613.54 $0.00 0 $3.61 $0.00 $84.02 $0.00 $676.76 1. EPO dose is based on USRDS 2013. For HD 14000/week for Month1, 22000/week for Month2, 19000/week for Month3; for PD 7500/week for Month1, 10000/week for Month2, 9500/week for Month 3 (USRDS 2013 (Figures 2.5 & 2.11)). (2) The rest of the doses are from the survey. Costs are from CMS.(27)