Keys to Depression Depression causes great turmoil and pain. Teens with depression need to be taken seriously, and caring adults and peers must take action to get help. Depression is a significant factor in most if not all suicide attempts. Depression and alcohol are the greatest contributors to teen suicide. Depression is twice as common among females as among males. One in ten high school students are depressed. Depression affects the way teens think about themselves, losing motivation, take little pleasure in living, look joyless and feel worthless. They become pessimistic and down on themselves. Depression affects basic biological functions. Sleep patterns and eating habits change. Depressed teens either become super busy or withdraw. Both boys and girls respond in self-destructive ways. Girls tend to show quietly disturbed feelings—worrying, loneliness, feeling unloved, fear of losing their minds, loss of hope for the future. Guys show more acting out behaviors such as being irritable, fighting, destroying property, running away, and hurting themselves.