Immunology of Fungal Infections
January 16-21, 2011
Hotel Galvez
Galveston, TX
Chair:
Gordon Brown
Vice Chairs:
Stuart M. Levitz & Luigina Romani
Fungal diseases have emerged as major causes of morbidity and mortality in immunocompromised
individuals. A fine-tuned immune response is critical, as either insufficient or exaggerated responses
compromise the host's ability to eradicate fungal infection.
Contributors
SUNDAY
4:00 pm - 8:00 pm
Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pm
Dinner
7:30 pm - 7:45 pm
Welcome / Introductory Comments by GRC Site Staff
7:45 pm - 9:30 pm
Fungal PAMPS
Discussion Leader: Carl Figdor (Nijmegen Centre for Molecular
Life Sciences)
7:45 pm - 8:10 pm
Frans Klis (University of Amsterdam)
"Lessons to be learned from the wall proteome and secretome of
C. albicans for infection detection and vaccine development"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Neil Gow (University of Aberdeen)
"Fungal cell walls and the activation of the innate immune
response"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
William Goldman (University of North Carolina)
"Molecular mimicry and crypsis in Histoplasma pathogenesis"
9:20 pm - 9:30 pm
Discussion
MONDAY
7:30 am - 8:30 am
Breakfast
8:30 am
Group Photo
9:00 am - 12:30 pm
Innate Fungal Recognition
Discussion Leader: Daniel Poulain (Université Lille)
9:00 am - 9:25 am
Mihai Netea (Radboud University)
"Innate immune discrimination of Candida colonization vs.
invasion"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am Joseph El Khoury (Massachusetts General Hospital)
"Scavenger receptors and Fungal pathogenesis"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 am Coffee Break
10:35 am - 11:00 am Jurgen Ruland (Technischen Universität München)
"ITAM Receptor Signaling in Innate Antifungal Immunity"
11:00 am - 11:10 am Discussion
11:10 am - 11:35 am Carl Figdor (Nijmegen Centre for Molecular Life Sciences)
"C-type lectins in fungal recognition"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 am Lars Erwig (University of Aberdeen)
"Video microscopy and sophisticated image analysis reveal novel
insights into the phagocytosis of C. albicans"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Duccio Cavalieri (University of Firenze)
"A Systems Biology approach to dissect early transcriptional
events regulating immune discrimination of fungi"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Jay Vyas (Massachusetts General Hospital)
"TLR9 is recruited to Aspergillus fumigatus phagosomes"
12:25 pm - 12:30 pm Discussion
12:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session I
6:00 pm
Dinner
7:30 pm - 9:30 pm
Adaptive Immunity and Immune Regulation
Discussion Leader: Bruce Klein (University of WisconsinMadison)
7:30 pm - 7:55 pm
Caetano Reis e Sousa (Cancer Research UK)
"Dendritic cells in the response to fungal infection"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Arturo Casadevall (Albert Einstein College of Medicine)
"New basic immunological insights into antibody function from
studies with Cryptococcus neoformans"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Anna Vecchiarelli (University of Perugia)
"C. neoformans capsular polysaccharide and T cell damage"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Teunis Geijtenbeek (University of Amsterdam)
"Dectin-1 signaling links extracellular fungal recognition to
inflammasome-independent IL-1beta processing"
9:25 pm - 9:30 pm
Discussion
TUESDAY
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Organ-Specific Immunity
Discussion Leader: Francoise Dromer (Institute Pasteur)
9:00 am - 9:25 am
Sarah Gaffen (University of Pittsburgh)
"Th17 cells and IL-17 receptor signaling in oral candidiasis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am Paul Fidel (Louisiana State University)
"New paradigms for host responses associated with vaginal
candidiasis: the role of innate immunity"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 am Coffee Break
10:35 am - 11:00 am Bernhard Hube (Hans Knoell Institute)
"Interactions of Candida albicans with oral epithelial cells"
11:00 am - 11:10 am Discussion
11:10 am - 11:35 am Scott Filler (David Geffen School of Medicine at UCLA)
"Mechanisms of C. albicans trafficking to the brain"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 am Dan Kaplan (University of Minnesota)
"Langerhans cells and Langerin+ dermal dendritic cells
reciprocally regulate the generation of Candida albicans specific
Th17 and Th1 cells"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Eric Pearlman (Case Western Reserve University)
"The role of innate and adaptive immunity in Aspergillus and
Fusarium infections of the cornea"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Tobias Hohl (Fred Hutchinson Cancer Research Center)
"Monocyte-dependent antifungal defense in the lung"
12:25 pm - 12:30 pm Discussion
12:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session I
6:00 pm
Dinner
7:30 pm - 9:30 pm
Fungal Diseases and Immunodeficiency
Discussion Leader: David Denning (The University of
Manchester)
7:30 pm - 7:55 pm
Kieren Marr (Johns Hopkins Medical School)
"Prevention of fungal infections after transplant: Translating
immunologic risks into treatment strategies"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Brahm Segal (Roswell Park Cancer Institute)
"NADPH oxidase: a master regulator of antifungal host defense
and inflammation"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Jay Kolls (LSU Health Sciences Center)
"Regulation of CD4+ T-cell responses to fungi"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Teresa Zelante (Università degli Studi di Perugia)
"IL-22 provides antifungal resistance at mucosal surfaces"
9:25 pm - 9:30 pm
Discussion
WEDNESDAY
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immunity to Specific Pathogens
Discussion Leader: Anna Vecchiarelli (University of Perugia)
9:00 am - 9:25 am
Vera Calich (Instituto de Diencias Biomedicas)
"Treg cells in paracoccidioidomycosis: friend or foe?"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am Frank Ebel (Ludwig-Maximilians-University)
"Interactions of Aspergillus fumigatus with human innate immune
cells"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 am Coffee Break
10:35 am - 11:00 am Chad Steele (University of Alabama at Birmingham)
"Macrophage activation during Pneumocystis lung infection"
11:00 am - 11:10 am Discussion
11:10 am - 11:35 am Bruce Klein
"Regulation of vaccine immunity to dimorphic fungi"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 am Joshua Fierer (University of California, San Diego)
"Pattern recognition receptors and innate immunity to
coccidioidomycosis"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Louis de Repentigny (Université de Montréal)
"Differential susceptibility to cryptococcosis in mice expressing
the HIV-1 transgene"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Amariliz Rivera (UMDNJ-New Jersey Medical School)
"Innate immune receptors and the differentiation of Aspergillus
fumigatus-specific CD4 T cells"
12:25 pm - 12:30 pm Discussion
12:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session II
6:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the next Vice Chair; Fill out Conference
Evaluation Forms; Discuss future Site & Scheduling preferences;
Election of the next Vice Chair
7:30 pm - 9:30 pm
Immunotherapy and Vaccination
Discussion Leader: Scott Filler (Harbor-UCLA Medical Center)
7:30 pm - 7:55 pm
Marcel Wuethrich (University of Wisconsin)
"Vaccination against the North American Systemic Mycoses
requires Th17 cells"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Antonio Cassone (Istituto Superiore di Sanita)
"Vaccination against opportunistic fungal infections with
emphasis on universal vaccines"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
David Denning (National Aspergillosis Centre Manchester)
"Clinical study of an Aspergillus vaccine - who and how"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Haibin Huang (University of Massachusetts)
"Relative contributions of Dectin-1 and complement to immune
responses to beta-glucan particles"
9:25 pm - 9:30 pm
Discussion
THURSDAY
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Fungal Diseases as a Consequence of
Immunomodulation
Discussion Leader: Bart Jan Kullberg (Radboud University)
9:00 am - 9:25 am
Jean-Paul Latge (Institute Pasteur)
"Extracellular vs skeletal cell wall polysaccharides of Aspergillus
fumigatus: To be or not to be immunogenic..."
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am George Deepe (University of Cincinnati College of Medicine)
"Cytokine-Chemokine Networks in Histoplasmosis"
10:00 am - 10:10 am Discussion
10:10 am - 10:35 am Coffee Break
10:35 am - 11:00 am Kazuyoshi Kawakami (Tohoku University Graduate School of
Medicine)
"Host defense strategies targeting polysaccharides and glycolipids
against Cryptococcus neoformans"
11:00 am - 11:10 am Discussion
11:10 am - 11:35 am Flavia De Bernardis (Istituto Superiore di Sanità)
"Positive and negative immunomodulation in vaginal candidiasis"
11:35 am - 11:45 am Discussion
11:45 am - 11:55 am Agostinho Carvalho (University of Perugia)
"Cracking the genetic code for susceptibility to aspergillosis in
allogeneic stem cell transplantation"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Kirsten Nielsen (Univeristy of Minnesota)
"Interaction between cryptococcal titan cells and the innate
immune system affects pathogenesis"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Floyd Wormley (The University of Texas at San Antonio)
"Induction of Protective Immunity against Pulmonary
Cryptococcosis"
12:25 pm - 12:30 pm Discussion
12:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session II
6:00 pm
Dinner
7:30 pm - 9:30 pm
From Bench to Bedside and Back Again
Discussion Leader: Jay Kolls (Louisiana State University)
7:30 pm - 7:55 pm
Liise-anne Pirofski (Albert Einstein College of Medicine)
"Antibody, B cells and immunity to Cryptococcus neoformans:
new perspectives on an old question"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Tom Harrison (St George's University of London)
"Interferon-gamma therapy for cryptococcosis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Bart-Jan Kullberg (Radboud University)
"Identifying patients at risk for candidiasis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Mihalis Lionakis (National Institutes of Allergy & Infectious
Diseases)
"Organ-specific Innate Immune Responses in a Mouse Model of
Invasive Candidiasis"
9:25 pm - 9:30 pm
Discussion
FRIDAY
7:30 am - 8:30 am
Breakfast
9:00 am
Departure