Supp. Table S8. The enriched functional terms of 11 hub genes from the ECimplicated interactome.
Name
Pathways in cancer
cellular response to endogenous stimulus
enzyme linked receptor protein signaling pathway
Colorectal cancer
Chronic myeloid leukemia
TGF-beta Receptor Signaling Pathway
Integrated Breast Cancer Pathway
Prostate cancer
Integrated Pancreatic Cancer Pathway
p53 pathway feedback loops 2
Nongenotropic Androgen signaling
Endometrial cancer
response to endogenous stimulus
Estrogen signaling pathway
positive regulation of transcription from RNA polymerase II promoter
Inhibition of Cellular Proliferation by Gleevec
HTLV-I infection
Regulation of Telomerase
Hepatitis B
Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar
Macrophages
Prolactin signaling pathway
Prolactin Signaling Pathway
cellular response to growth factor stimulus
Regulation of nuclear SMAD2/3 signaling
response to growth factor
cellular response to organic substance
Small cell lung cancer
transcription factor binding
transcription regulatory region DNA binding
regulatory region DNA binding
regulatory region nucleic acid binding
positive regulation of transcription, DNA-templated
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
negative regulation of cell death
IL2 signaling events mediated by PI3K
IL-2 Receptor Beta Chain in T cell Activation
positive regulation of gene expression
IL-6 Signaling Pathway
Epstein-Barr virus infection
q-value
FDR B&H
5.34E-12
1.48E-11
1.48E-11
1.94E-11
3.82E-11
3.82E-11
3.82E-11
8.98E-11
1.70E-10
1.70E-10
2.83E-10
3.39E-10
3.60E-10
4.18E-10
4.71E-10
8.30E-10
1.07E-09
1.07E-09
1.24E-09
1.49E-09
1.52E-09
1.85E-09
1.95E-09
2.23E-09
2.03E-09
2.61E-09
3.86E-09
5.20E-09
5.20E-09
5.20E-09
5.20E-09
3.89E-09
4.81E-09
5.14E-09
5.19E-09
6.11E-09
6.71E-09
6.18E-09
7.96E-09
7.96E-09
regulation of apoptotic process
regulation of programmed cell death
cellular response to hormone stimulus
positive regulation of macromolecule biosynthetic process
positive regulation of developmental process
positive regulation of nucleobase-containing compound metabolic process
IL6-mediated signaling events
regulation of cell death
positive regulation of nitrogen compound metabolic process
Prostate Cancer
transcription regulatory region sequence-specific DNA binding
Proteoglycans in cancer
positive regulation of cellular biosynthetic process
positive regulation of biosynthetic process
regulation of transcription from RNA polymerase II promoter
B Cell Survival Pathway
Tumor Suppressor Arf Inhibits Ribosomal Biogenesis
Human Cytomegalovirus and Map Kinase Pathways
Acute myeloid leukemia
Fc-epsilon receptor I signaling in mast cells
Oncostatin M Signaling Pathway
Corticosteroids and cardioprotection
TSH signaling pathway
transcription from RNA polymerase II promoter
apoptotic process
BCR signaling pathway
Pancreatic cancer
transmembrane receptor protein tyrosine kinase signaling pathway
Trefoil Factors Initiate Mucosal Healing
programmed cell death
negative regulation of apoptotic process
Lung Neoplasms
negative regulation of programmed cell death
AKT Signaling Pathway
Ras Signaling Pathway
CTCF: First Multivalent Nuclear Factor
B cell receptor signaling pathway
cell-type specific apoptotic process
regulation of developmental process
T cell activation
structure-specific DNA binding
EGFR1 Signaling Pathway
p53 pathway
Plasma membrane estrogen receptor signaling
Influence of Ras and Rho proteins on G1 to S Transition
cellular response to abiotic stimulus
7.88E-09
8.22E-09
9.46E-09
9.46E-09
9.46E-09
9.46E-09
1.13E-08
1.01E-08
1.09E-08
1.27E-08
1.71E-08
1.46E-08
1.57E-08
1.82E-08
2.39E-08
2.91E-08
3.55E-08
3.55E-08
3.94E-08
4.55E-08
6.19E-08
6.33E-08
6.33E-08
6.07E-08
6.13E-08
7.01E-08
7.01E-08
6.14E-08
7.03E-08
6.35E-08
6.35E-08
8.67E-08
7.05E-08
8.37E-08
9.64E-08
9.64E-08
9.64E-08
8.70E-08
8.70E-08
1.24E-07
1.58E-07
1.41E-07
1.42E-07
1.42E-07
1.42E-07
1.34E-07
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region DNA binding
double-stranded DNA binding
Glucocorticoid receptor regulatory network
Apoptosis
Apoptosis
Androgen receptor signaling pathway
response to hormone
DNA damage response (only ATM dependent)
regulation of cell differentiation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
Osteopontin-mediated events
E-cadherin signaling in the nascent adherens junction
regulation of multicellular organismal development
Estrogen signaling pathway
nucleoplasm
ErbB2/ErbB3 signaling events
Apoptosis signaling pathway
Regulation of toll-like receptor signaling pathway
Toll-like receptor signaling pathway
ErbB1 downstream signaling
Adrenergic Pathway
Chagas disease (American trypanosomiasis)
T cell receptor signaling pathway
Toll-like receptor signaling pathway
TSLP Signaling Pathway
MicroRNAs in cardiomyocyte hypertrophy
TNF signaling pathway
B Cell Antigen Receptor
transcription factor activity, sequence-specific DNA binding
nucleic acid binding transcription factor activity
positive regulation of response to stimulus
IL-2 Signaling pathway
apoptotic signaling pathway
Neurotrophin signaling pathway
TWEAK Signaling Pathway
COLORECTAL CANCER; CRC
Familial cancer of breast
BREAST CANCER
negative regulation of cell proliferation
Presenilin action in Notch and Wnt signaling
T Cell Receptor Signaling Pathway
FGF signaling pathway
Angiopoietin receptor Tie2-mediated signaling
Osteoclast differentiation
1.96E-07
1.96E-07
1.96E-07
1.64E-07
1.71E-07
2.00E-07
2.21E-07
2.04E-07
2.56E-07
2.29E-07
2.51E-07
2.51E-07
3.01E-07
3.36E-07
3.12E-07
3.91E-07
5.40E-07
4.10E-07
4.10E-07
4.10E-07
4.16E-07
4.16E-07
4.16E-07
4.16E-07
4.16E-07
4.51E-07
5.03E-07
5.03E-07
5.19E-07
5.94E-07
7.64E-07
7.64E-07
5.93E-07
7.16E-07
6.40E-07
7.67E-07
7.67E-07
1.04E-06
1.04E-06
1.04E-06
7.79E-07
9.99E-07
1.06E-06
1.06E-06
1.14E-06
1.14E-06
Hepatitis C
Measles
sequence-specific DNA binding
negative regulation of macromolecule metabolic process
negative regulation of response to stimulus
regulation of apoptotic signaling pathway
Neoplasm of ovary
IL2-mediated signaling events
regulation of glucose import
Trka Receptor Signaling Pathway
BDNF signaling pathway
RANKL/RANK Signaling Pathway
PDGFR-beta signaling pathway
tissue development
Non-small cell lung cancer
Angiogenesis
Fc-epsilon receptor signaling pathway
OVARIAN CANCER
Carcinoma, Hepatocellular
glucose import
regulation of immune system process
response to mechanical stimulus
negative regulation of metabolic process
response to organic cyclic compound
Leptin signaling pathway
Atypical NF-kappaB pathway
regulation of phosphorylation
response to wounding
response to organonitrogen compound
p75(NTR)-mediated signaling
Breast Neoplasms
Adenocarcinoma
HEPATOCELLULAR CARCINOMA
Hepatocellular carcinoma
RNA polymerase II transcription factor binding
Signaling events mediated by VEGFR1 and VEGFR2
The IGF-1 Receptor and Longevity
MAPK signaling pathway
IL-4 signaling Pathway
phosphorylation
LPA receptor mediated events
Glioma
Cadmium induces DNA synthesis and proliferation in macrophages
Role of nicotinic acetylcholine receptors in the regulation of apoptosis
core promoter binding
PI3K-Akt signaling pathway
1.17E-06
1.20E-06
1.50E-06
1.15E-06
1.17E-06
1.18E-06
1.63E-06
1.51E-06
1.36E-06
1.63E-06
1.66E-06
1.67E-06
1.67E-06
1.51E-06
1.92E-06
1.94E-06
1.74E-06
2.38E-06
2.43E-06
1.89E-06
1.89E-06
1.97E-06
2.05E-06
2.11E-06
2.47E-06
2.47E-06
2.20E-06
2.22E-06
2.22E-06
2.59E-06
3.11E-06
3.11E-06
3.11E-06
3.11E-06
3.30E-06
2.92E-06
2.99E-06
3.00E-06
3.01E-06
2.73E-06
3.14E-06
3.14E-06
3.45E-06
3.45E-06
4.23E-06
3.47E-06
positive regulation of phosphorylation
AMPK signaling
IL-5 Signaling Pathway
cellular response to oxygen-containing compound
Alpha6-Beta4 Integrin Signaling Pathway
regulation of fibroblast proliferation
response to nitrogen compound
Melanoma
Prostatic Neoplasms
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Telomeres, Telomerase, Cellular Aging, and Immortality
PTEN dependent cell cycle arrest and apoptosis
Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy
Nerve growth factor pathway (NGF)
Role of Erk5 in Neuronal Survival
fibroblast proliferation
E-cadherin signaling in keratinocytes
Fc epsilon receptor (FCERI) signaling
Fc receptor signaling pathway
Regulation of Wnt-mediated beta catenin signaling and target gene transcription
Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway
Signaling Pathways in Glioblastoma
protein phosphatase binding
regulation of cell proliferation
regulation of neuron death
CD28 dependent PI3K/Akt signaling
IGF-1 Signaling Pathway
Viral carcinogenesis
Delta-Notch Signaling Pathway
Signaling events mediated by the Hedgehog family
Role of ERBB2 in Signal Transduction and Oncology
PDGFR-alpha signaling pathway
Insulin Signaling Pathway
negative regulation of signal transduction
cellular response to external stimulus
ErbB signaling pathway
mTOR Signaling Pathway
Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation
VEGFR3 signaling in lymphatic endothelium
regulation of glucose transport
Corticotropin-releasing hormone
regulation of smooth muscle cell proliferation
TCR Signaling Pathway
CXCR4 Signaling Pathway
TPO Signaling Pathway
Regulation of eIF4e and p70 S6 Kinase
3.09E-06
3.62E-06
3.80E-06
3.47E-06
3.99E-06
3.55E-06
3.55E-06
4.18E-06
5.06E-06
4.38E-06
4.50E-06
4.50E-06
4.50E-06
4.50E-06
4.50E-06
4.00E-06
5.29E-06
5.44E-06
5.06E-06
5.92E-06
6.05E-06
6.11E-06
7.75E-06
5.61E-06
5.88E-06
6.87E-06
6.87E-06
6.95E-06
7.53E-06
7.55E-06
7.55E-06
7.55E-06
7.55E-06
6.79E-06
6.79E-06
8.31E-06
8.40E-06
8.40E-06
8.40E-06
7.41E-06
8.80E-06
7.91E-06
9.13E-06
9.23E-06
9.23E-06
9.23E-06
Interleukin signaling pathway
intrinsic apoptotic signaling pathway
muscle structure development
smooth muscle cell proliferation
negative regulation of signaling
negative regulation of cell communication
Nectin adhesion pathway
neurotrophin TRK receptor signaling pathway
neurotrophin signaling pathway
neuron death
regulation of myeloid leukocyte differentiation
Nephrin/Neph1 signaling in the kidney podocyte
Regulation of BAD phosphorylation
WNT Signaling Pathway
Hypoxia response via HIF activation
Phospholipids as signalling intermediaries
Transcription factor CREB and its extracellular signals
Genes related to IL4 rceptor signaling in B lymphocytes
response to abiotic stimulus
Neural Crest Differentiation
phosphatidylinositol 3-kinase complex, class IA
IGF1 pathway
IL-3 Signaling Pathway
response to UV
HIF-1 signaling pathway
Thyroid cancer
Reelin signaling pathway
VEGFR1 specific signals
cell projection
neuron part
cellular response to organic cyclic compound
IL2 signaling events mediated by STAT5
CD40/CD40L signaling
Control of skeletal myogenesis by HDAC and calcium/calmodulin-dependent kinase
(CaMK)
MAPK signaling pathway
intracellular steroid hormone receptor signaling pathway
epithelial cell proliferation
EGF Signaling Pathway
a6b1 and a6b4 Integrin signaling
Hemangiosarcoma
Cholinergic synapse
GPVI-mediated activation cascade
Trk receptor signaling mediated by PI3K and PLC-gamma
CD28 co-stimulation
PDGF Signaling Pathway
9.24E-06
8.52E-06
8.52E-06
8.52E-06
8.69E-06
8.69E-06
1.03E-05
9.22E-06
9.59E-06
9.79E-06
9.83E-06
1.13E-05
1.13E-05
1.13E-05
1.13E-05
1.24E-05
1.24E-05
1.24E-05
1.10E-05
1.26E-05
1.75E-05
1.37E-05
1.39E-05
1.23E-05
1.48E-05
1.48E-05
1.48E-05
1.48E-05
2.05E-05
2.05E-05
1.41E-05
1.61E-05
1.61E-05
1.61E-05
1.66E-05
1.46E-05
1.46E-05
1.74E-05
1.74E-05
2.12E-05
1.80E-05
1.86E-05
1.86E-05
1.86E-05
1.86E-05
cellular response to peptide hormone stimulus
response to light stimulus
negative regulation of cellular metabolic process
epithelium development
MAPK cascade
phosphatase binding
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
N-cadherin signaling events
transcriptional activator activity, RNA polymerase II core promoter proximal region
sequence-specific binding
cellular response to peptide
response to oxidative stress
positive regulation of multicellular organismal process
Insulin/IGF pathway-protein kinase B signaling cascade
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Genes related to CD40 signaling
CXCR3-mediated signaling events
phosphatidylinositol 3-kinase-Akt signaling
Gastric cancer network 2
positive regulation of cell differentiation
Toxoplasmosis
glucose transport
IL1-mediated signaling events
FAS (CD95) signaling pathway
hexose transport
Signalling by NGF
wound healing
monosaccharide transport
negative regulation of smooth muscle cell proliferation
RNA polymerase II core promoter proximal region sequence-specific DNA binding
chromatin binding
signal transduction by protein phosphorylation
immune response-regulating cell surface receptor signaling pathway
regulation of sequence-specific DNA binding transcription factor activity
PDGF signaling pathway
Signaling of Hepatocyte Growth Factor Receptor
IL23-mediated signaling events
core promoter proximal region sequence-specific DNA binding
core promoter proximal region DNA binding
MicroRNAs in cancer
repressing transcription factor binding
muscle cell proliferation
insulin-like growth factor receptor signaling pathway
response to lipid
FOXM1 transcription factor network
Fc Epsilon Receptor I Signaling in Mast Cells
1.63E-05
1.66E-05
1.68E-05
1.71E-05
1.73E-05
2.47E-05
2.02E-05
2.02E-05
2.49E-05
1.82E-05
1.86E-05
1.86E-05
2.13E-05
2.13E-05
2.13E-05
2.13E-05
2.13E-05
2.13E-05
1.94E-05
2.25E-05
1.98E-05
2.29E-05
2.29E-05
2.02E-05
2.31E-05
2.04E-05
2.09E-05
2.11E-05
3.01E-05
3.01E-05
2.19E-05
2.20E-05
2.21E-05
2.58E-05
2.65E-05
2.65E-05
3.30E-05
3.34E-05
2.77E-05
3.57E-05
2.55E-05
2.57E-05
2.59E-05
3.06E-05
3.06E-05
cell proliferation
positive regulation of immune system process
regulation of phosphate metabolic process
Signal Transduction
response to steroid hormone
negative regulation of myeloid leukocyte differentiation
IFN-gamma pathway
regulation of phosphorus metabolic process
regulation of establishment of protein localization to plasma membrane
enzyme binding
regulation of protein localization to plasma membrane
LKB1 signaling events
fungiform papilla morphogenesis
fungiform papilla formation
altered phosphatodylinositol 3-kinase-Akt signaling
Insulin Pathway
FOXA1 transcription factor network
regulation of organ morphogenesis
transcriptional activator activity, RNA polymerase II transcription regulatory region
sequence-specific binding
transcription factor activity, RNA polymerase II core promoter proximal region
sequence-specific binding
nitric-oxide synthase regulator activity
cellular response to UV
Ceramide signaling pathway
carbohydrate transport
negative regulation of neuron death
Signaling by ERBB4
Carbohydrate digestion and absorption
Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor
Pathway.
Genes related to chemotaxis
response to oxygen-containing compound
cellular response to oxidative stress
hematopoietic or lymphoid organ development
Non-alcoholic fatty liver disease (NAFLD)
Members of the BCR signaling pathway
Integrins in angiogenesis
core promoter sequence-specific DNA binding
Downstream TCR signaling
regulation of monooxygenase activity
T cell activation
positive regulation of cell proliferation
branching morphogenesis of an epithelial tube
female pregnancy
regulation of myeloid cell differentiation
genitalia development
2.79E-05
2.80E-05
2.80E-05
3.22E-05
2.84E-05
2.84E-05
3.27E-05
2.86E-05
3.01E-05
4.38E-05
3.21E-05
3.78E-05
3.42E-05
3.42E-05
3.92E-05
3.99E-05
3.99E-05
3.55E-05
4.99E-05
4.99E-05
4.99E-05
3.57E-05
4.25E-05
3.74E-05
3.80E-05
4.46E-05
4.46E-05
4.46E-05
4.46E-05
3.91E-05
3.91E-05
3.98E-05
4.66E-05
4.69E-05
4.69E-05
6.03E-05
4.98E-05
4.39E-05
4.39E-05
4.48E-05
4.48E-05
4.48E-05
4.48E-05
4.48E-05
negative regulation of apoptotic signaling pathway
Jak-STAT signaling pathway
PI3 kinase pathway
response to peptide hormone
Liver Neoplasms
Carcinoma, Squamous Cell
Infertility, Female
immune system development
fungiform papilla development
fibroblast growth factor receptor signaling pathway
SIDS Susceptibility Pathways
response to radiation
myeloid leukocyte differentiation
Insulin Signaling
prostate gland development
response to peptide
Genes related to the insulin receptor pathway
transforming growth factor beta receptor signaling pathway
regulation of cell cycle
immune response
hormone binding
leukocyte differentiation
Signaling events mediated by PTP1B
Signaling events mediated by Stem cell factor receptor (c-Kit)
transcription initiation from RNA polymerase II promoter
cellular response to organonitrogen compound
innate immune response
regulation of morphogenesis of a branching structure
maternal process involved in female pregnancy
steroid hormone receptor binding
Downstream Signaling Events Of B Cell Receptor (BCR)
NFAT and Hypertrophy of the heart (Transcription in the broken heart)
cellular response to fibroblast growth factor stimulus
mammary gland branching involved in pregnancy
canonical Wnt signaling pathway involved in negative regulation of apoptotic
process
hair follicle placode formation
regulation of neuron apoptotic process
response to fibroblast growth factor
TGF Beta Signaling Pathway
immune response-regulating signaling pathway
morphogenesis of a branching epithelium
Coregulation of Androgen receptor activity
Transcriptional misregulation in cancer
Influenza A
canonical Wnt signaling pathway
4.54E-05
5.19E-05
5.25E-05
4.60E-05
6.51E-05
6.53E-05
6.53E-05
4.90E-05
4.90E-05
4.90E-05
5.68E-05
5.15E-05
5.25E-05
6.08E-05
5.35E-05
5.37E-05
6.22E-05
5.45E-05
5.45E-05
5.50E-05
7.75E-05
5.62E-05
6.53E-05
6.53E-05
5.86E-05
6.08E-05
6.13E-05
6.21E-05
6.21E-05
8.72E-05
7.20E-05
7.24E-05
6.46E-05
6.46E-05
6.46E-05
6.46E-05
6.55E-05
6.63E-05
7.62E-05
6.82E-05
6.92E-05
8.40E-05
8.40E-05
8.40E-05
7.40E-05
positive regulation of carbohydrate metabolic process
Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)
VEGF signaling pathway
regulation of transport
regulation of intracellular signal transduction
regulation of osteoclast differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
cellular response to nitrogen compound
androgen receptor signaling pathway
growth
morphogenesis of a branching structure
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
mTOR signaling pathway
neuron projection
VEGF signaling pathway
negative regulation of lipid metabolic process
Chemokine signaling pathway
blood coagulation
epidermal growth factor receptor signaling pathway
neuron apoptotic process
coagulation
multi-multicellular organism process
regulation of leukocyte differentiation
hemostasis
DNA-templated transcription, initiation
Carcinoma of colon
Penile Neoplasms
ERBB signaling pathway
cellular response to mechanical stimulus
IL4-mediated signaling events
1-phosphatidylinositol-3-kinase activity
glucose metabolic process
TCR signaling
tongue morphogenesis
T cell costimulation
regulation of protein localization
lymphocyte costimulation
lymphocyte apoptotic process
Renal cell carcinoma
insulin receptor substrate binding
negative regulation of leukocyte differentiation
mammary gland epithelium development
Genes related to PIP3 signaling in cardiac myocytes
negative regulation of cell differentiation
Focal adhesion
7.49E-05
8.72E-05
8.72E-05
7.71E-05
7.71E-05
7.71E-05
7.93E-05
7.93E-05
7.93E-05
7.96E-05
8.16E-05
8.16E-05
8.25E-05
9.62E-05
1.31E-04
1.01E-04
8.83E-05
1.02E-04
8.93E-05
8.93E-05
8.93E-05
9.08E-05
9.08E-05
9.08E-05
9.10E-05
9.12E-05
1.25E-04
1.25E-04
9.38E-05
9.50E-05
1.10E-04
1.36E-04
9.74E-05
1.15E-04
1.01E-04
1.05E-04
1.05E-04
1.09E-04
1.09E-04
1.25E-04
1.55E-04
1.12E-04
1.12E-04
1.30E-04
1.16E-04
1.39E-04
regulation of MAPK cascade
embryonic morphogenesis
regulation of oxidoreductase activity
Double Stranded RNA Induced Gene Expression
Fc epsilon RI signaling pathway
CDC42 signaling events
lymphocyte activation
epithelial cell differentiation
regulation of lipid metabolic process
Rap1 signaling pathway
Costimulation by the CD28 family
regulation of epithelial cell proliferation
regulation of T cell activation
embryo development
cellular response to light stimulus
negative regulation of myeloid cell differentiation
Endothelin signaling pathway
Signaling by the B Cell Receptor (BCR)
regulation of cellular component organization
hexose metabolic process
Infertility, Male
mitochondrial membrane organization
CXCR4-mediated signaling events
Bacterial invasion of epithelial cells
intracellular receptor signaling pathway
positive regulation of signal transduction
Ras signaling pathway
regulation of stem cell proliferation
negative regulation of gene expression
osteoclast differentiation
hair follicle development
molting cycle process
hair cycle process
regulation of reproductive process
negative regulation of macromolecule biosynthetic process
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1; BROVCA1
negative regulation of transcription from RNA polymerase II promoter
Hemostasis
establishment of protein localization to membrane
regulation of body fluid levels
positive regulation of signaling
Progesterone-mediated oocyte maturation
RB in Cancer
Constitutive PI3K/AKT Signaling in Cancer
MAPKinase Signaling Pathway
prostate gland growth
1.23E-04
1.23E-04
1.23E-04
1.47E-04
1.47E-04
1.52E-04
1.33E-04
1.33E-04
1.35E-04
1.56E-04
1.57E-04
1.38E-04
1.40E-04
1.40E-04
1.42E-04
1.42E-04
1.63E-04
1.65E-04
1.49E-04
1.51E-04
2.07E-04
1.56E-04
1.82E-04
1.82E-04
1.69E-04
1.70E-04
1.94E-04
1.70E-04
1.72E-04
1.75E-04
1.84E-04
1.84E-04
1.84E-04
1.89E-04
2.03E-04
2.81E-04
2.15E-04
2.52E-04
2.23E-04
2.23E-04
2.27E-04
2.59E-04
2.65E-04
2.65E-04
2.65E-04
2.32E-04
positive regulation of cell communication
monosaccharide metabolic process
single-organism membrane organization
Colonic Neoplasms
establishment of protein localization to plasma membrane
Bone Remodelling
leukocyte apoptotic process
urogenital system development
leukocyte activation
transmembrane receptor protein serine/threonine kinase signaling pathway
positive regulation of nitric-oxide synthase activity
epithelial cell differentiation involved in prostate gland development
genitalia morphogenesis
phosphatidylinositol 3-kinase activity
Fc gamma R-mediated phagocytosis
negative regulation of biosynthetic process
muscle cell differentiation
Multi-step Regulation of Transcription by Pitx2
TFs Regulate miRNAs related to cardiac hypertrophy
R-SMAD binding
negative regulation of developmental process
hair cycle
molting cycle
ectodermal placode formation
ectodermal placode morphogenesis
ectodermal placode development
single-organism carbohydrate metabolic process
cell development
system process
regulation of cell development
myeloid cell differentiation
intrinsic apoptotic signaling pathway in response to DNA damage
T cell receptor signaling pathway
epithelial tube morphogenesis
RNA polymerase II transcription factor activity, sequence-specific DNA binding
nuclear hormone receptor binding
negative regulation of intracellular signal transduction
phosphatidylinositol kinase activity
Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration
p53 signaling pathway
phosphatidylinositol-3-phosphate biosynthetic process
negative regulation of glucose import
transcription factor complex
Wnt signaling pathway
positive regulation of cellular component organization
striated muscle tissue development
2.33E-04
2.34E-04
2.35E-04
3.19E-04
2.38E-04
2.77E-04
2.44E-04
2.48E-04
2.55E-04
2.58E-04
2.58E-04
2.58E-04
2.58E-04
3.65E-04
3.00E-04
2.64E-04
2.64E-04
3.15E-04
3.15E-04
3.92E-04
2.85E-04
2.87E-04
2.87E-04
2.87E-04
2.87E-04
2.87E-04
2.91E-04
2.92E-04
2.99E-04
2.99E-04
2.99E-04
3.01E-04
3.01E-04
3.06E-04
4.30E-04
4.30E-04
3.08E-04
4.32E-04
3.57E-04
3.57E-04
3.13E-04
3.13E-04
4.83E-04
3.15E-04
3.25E-04
3.25E-04
regulation of lymphocyte activation
PIP3 activates AKT signaling
PI3K events in ERBB4 signaling
PI3K events in ERBB2 signaling
PI3K/AKT Signaling in Cancer
PI-3K cascade
regulation of organelle organization
Carcinoma
Sarcoma
Wnt Signaling Pathway and Pluripotency
PTEN is a tumor suppressor that dephosphorylates the lipid messenger
phosphatidylinositol triphosphate.
IL-7 Signal Transduction
EPHA2 forward signaling
The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and
promote cell growth.
hemopoiesis
fibroblast apoptotic process
positive regulation of lymphocyte apoptotic process
negative regulation of cell cycle
tube morphogenesis
PI3K/AKT activation
GAB1 signalosome
muscle organ development
chromatin remodeling
muscle tissue development
Regulation of signaling by CBL
morphogenesis of an epithelial bud
regulation of muscle cell differentiation
enzyme regulator activity
regulation of intrinsic apoptotic signaling pathway
immune response-activating signal transduction
cellular response to radiation
Amoebiasis
Chaperones modulate interferon Signaling Pathway
Tie2 Signaling
Signaling by FGFR1 fusion mutants
Downregulated of MTA-3 in ER-negative Breast Tumors
Paxillin-dependent events mediated by a4b1
TP53 network
protein complex binding
regulation of cell fate specification
negative regulation of glucose transport
protein localization to membrane
hormone receptor binding
regulation of immune response
3.25E-04
3.71E-04
3.71E-04
3.71E-04
3.71E-04
3.71E-04
3.30E-04
4.56E-04
4.56E-04
3.88E-04
3.88E-04
3.88E-04
3.88E-04
3.88E-04
3.39E-04
3.43E-04
3.43E-04
3.46E-04
3.46E-04
3.96E-04
4.06E-04
3.55E-04
3.62E-04
3.76E-04
4.31E-04
3.77E-04
3.85E-04
5.46E-04
3.92E-04
3.98E-04
3.98E-04
4.68E-04
4.68E-04
4.68E-04
4.68E-04
4.68E-04
4.68E-04
4.68E-04
5.74E-04
4.11E-04
4.11E-04
4.12E-04
5.84E-04
4.18E-04
positive regulation of cell cycle
protein localization to plasma membrane
Spinal Cord Injury
phosphatidylinositol 3-kinase complex
positive regulation of monooxygenase activity
negative regulation of osteoclast differentiation
Ras-Independent pathway in NK cell-mediated cytotoxicity
ATM Signaling Pathway
Signaling by constitutively active EGFR
negative regulation of transport
in utero embryonic development
Signaling by NOTCH
Wnt signaling pathway
Signaling by Interleukins
stem cell proliferation
regulation of leukocyte activation
The Co-Stimulatory Signal During T-cell Activation
p53 pathway by glucose deprivation
Leukocyte transendothelial migration
protein kinase binding
membrane organization
Prostatic Intraepithelial Neoplasia
mammary gland development
regulation of chromosome organization
mammary gland alveolus development
tongue development
mammary gland lobule development
Paxillin-independent events mediated by a4b1 and a4b7
Apoptotic Signaling in Response to DNA Damage
response to drug
antigen receptor-mediated signaling pathway
Huntington disease
gland development
Role of LAT2/NTAL/LAB on calcium mobilization
Cell cycle
Angiogenesis
Rac 1 cell motility signaling pathway
Hypoxia and p53 in the Cardiovascular system
Nephrin interactions
positive regulation of establishment of protein localization to plasma membrane
mesenchyme morphogenesis
protein phosphatase 2A binding
protein C-terminus binding
development of primary male sexual characteristics
chromosome organization
positive regulation of epithelial cell proliferation
4.28E-04
4.36E-04
5.02E-04
6.75E-04
4.47E-04
4.47E-04
5.11E-04
5.11E-04
5.11E-04
4.52E-04
4.52E-04
5.21E-04
5.24E-04
5.44E-04
4.77E-04
4.80E-04
5.54E-04
5.54E-04
5.66E-04
7.05E-04
5.05E-04
7.01E-04
5.23E-04
5.23E-04
5.23E-04
5.23E-04
5.23E-04
6.02E-04
6.02E-04
5.44E-04
5.46E-04
6.32E-04
5.55E-04
6.42E-04
6.42E-04
6.42E-04
6.42E-04
6.42E-04
6.42E-04
5.63E-04
5.63E-04
7.89E-04
8.02E-04
5.83E-04
5.84E-04
5.90E-04
activation of immune response
cellular response to stress
male genitalia development
single-organism biosynthetic process
regulation of cell activation
Adrenal Gland Neoplasms
IL-9 Signaling Pathway
Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia
blood circulation
positive regulation of apoptotic process
circulatory system process
embryonic organ development
negative regulation of autophagy
defense response
positive regulation of programmed cell death
carbohydrate metabolic process
Cell-Cell communication
cell growth
Retinoic acid receptors-mediated signaling
EGF receptor (ErbB1) signaling pathway
TRAIL signaling pathway
male sex differentiation
single-organism localization
single-organism cellular localization
regulation of carbohydrate metabolic process
organ induction
cell activation
reproductive structure development
organ morphogenesis
morphogenesis of an epithelium
Heat Stroke
Interleukin 4 (IL-4) Pathway
reproductive system development
positive regulation of protein insertion into mitochondrial membrane involved in
apoptotic signaling pathway
positive regulation of leukocyte apoptotic process
branching involved in mammary gland duct morphogenesis
regulation of protein insertion into mitochondrial membrane involved in apoptotic
signaling pathway
mitotic cell cycle
kinase binding
regulation of establishment of protein localization
multi-organism reproductive process
Signaling by SCF-KIT
negative regulation of lipid transport
morphogenesis of an epithelial fold
5.90E-04
6.00E-04
6.00E-04
6.00E-04
6.03E-04
8.22E-04
6.95E-04
6.95E-04
6.12E-04
6.15E-04
6.16E-04
6.16E-04
6.38E-04
6.41E-04
6.43E-04
6.44E-04
7.37E-04
6.50E-04
7.44E-04
7.44E-04
7.44E-04
6.53E-04
6.58E-04
6.58E-04
6.58E-04
6.70E-04
6.84E-04
6.92E-04
6.93E-04
6.93E-04
9.47E-04
8.03E-04
7.03E-04
7.03E-04
7.03E-04
7.03E-04
7.03E-04
7.03E-04
9.98E-04
7.24E-04
7.32E-04
8.43E-04
7.42E-04
7.42E-04
regulation of neuroblast proliferation
Wnt signaling pathway
Ephrin B reverse signaling
Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells
3-phosphoinositide biosynthesis
lipid modification
Notch signaling pathway
Insulin signaling pathway
androgen receptor binding
multicellular organism growth
negative regulation of stress-activated protein kinase signaling cascade
negative regulation of stress-activated MAPK cascade
protein insertion into mitochondrial membrane involved in apoptotic signaling
pathway
negative regulation of fibroblast proliferation
positive regulation of cell death
Cell Cycle: G1/S Check Point
G alpha q Pathway
Growth Hormone Signaling Pathway
Activation of BH3-only proteins
glutamate receptor binding
Downstream signaling of activated FGFR
estrogen receptor binding
cell cycle
protein insertion into mitochondrial membrane
positive regulation of molecular function
regulation of cellular protein metabolic process
regulation of cellular localization
negative regulation of molecular function
skeletal muscle tissue development
Urinary Bladder Neoplasms
Ovarian Neoplasms
Colorectal Neoplasms
Adenocarcinoma Of Esophagus
Interleukin receptor SHC signaling
VEGF, Hypoxia, and Angiogenesis
plasma membrane organization
glial cell differentiation
regulation of cell cycle process
regulation of oligodendrocyte differentiation
negative regulation of transcription, DNA-templated
insulin receptor signaling pathway
Adrenergic signaling in cardiomyocytes
Axon guidance mediated by netrin
Signaling by FGFR1 mutants
regulation of cell fate commitment
7.42E-04
8.51E-04
8.51E-04
8.51E-04
8.51E-04
7.56E-04
7.56E-04
8.83E-04
1.08E-03
7.80E-04
7.80E-04
7.80E-04
7.80E-04
7.80E-04
7.82E-04
9.00E-04
9.00E-04
9.00E-04
9.00E-04
1.11E-03
9.23E-04
1.14E-03
8.17E-04
8.27E-04
8.27E-04
8.31E-04
8.31E-04
8.31E-04
8.31E-04
1.13E-03
1.13E-03
1.13E-03
1.13E-03
9.56E-04
9.56E-04
8.40E-04
8.40E-04
8.61E-04
8.61E-04
8.69E-04
8.72E-04
1.01E-03
1.01E-03
1.01E-03
9.06E-04
prostate gland epithelium morphogenesis
skeletal muscle organ development
RNA polymerase II core promoter sequence-specific DNA binding
Burkitt Lymphoma
Aurora A signaling
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
IL17 signaling pathway
negative regulation of RNA biosynthetic process
regulation of response to stress
anatomical structure formation involved in morphogenesis
Liver Neoplasms, Experimental
Downstream signal transduction
ErbB4 signaling events
Oxidative Stress
protein dimerization activity
receptor tyrosine kinase binding
phosphatidylinositol phosphorylation
prostate gland morphogenesis
positive regulation of T cell activation
positive regulation of immune response
Signaling by FGFR
Signaling by ERBB2
B Cell Receptor Signaling Pathway
DAP12 signaling
EPHB forward signaling
EPO signaling pathway
Synthesis of PIPs at the plasma membrane
Signaling of Hepatocyte Growth Factor Receptor
transcription factor activity, direct ligand regulated sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific
DNA binding
positive regulation of glucose import
Apoptosis
negative regulation of RNA metabolic process
Wnt/beta-catenin Pathway
Internalization of ErbB1
epithelial cell development
Adrenocortical Carcinoma
Psychoses, Substance-Induced
regulation of polysaccharide biosynthetic process
positive regulation of mesenchymal cell proliferation
chromatin modification
CARM1 and Regulation of the Estrogen Receptor
Signaling mediated by p38-alpha and p38-beta
Integrated Cancer pathway
hyaluronan metabolic process
9.06E-04
9.06E-04
1.29E-03
1.26E-03
1.07E-03
1.07E-03
1.07E-03
9.39E-04
9.39E-04
9.54E-04
1.32E-03
1.13E-03
1.13E-03
1.13E-03
1.39E-03
1.40E-03
1.01E-03
1.01E-03
1.01E-03
1.01E-03
1.16E-03
1.17E-03
1.17E-03
1.17E-03
1.17E-03
1.17E-03
1.17E-03
1.17E-03
1.46E-03
1.46E-03
1.06E-03
1.22E-03
1.08E-03
1.23E-03
1.23E-03
1.09E-03
1.49E-03
1.49E-03
1.11E-03
1.11E-03
1.11E-03
1.30E-03
1.30E-03
1.30E-03
1.16E-03
regulation of nitric-oxide synthase activity
specification of organ identity
Signaling events mediated by TCPTP
Genes related to PIP3 signaling in B lymphocytes
Nasopharyngeal carcinoma
activating transcription factor binding
steroid hormone receptor activity
positive regulation of reproductive process
positive regulation of oxidoreductase activity
cell migration
negative regulation of cellular protein metabolic process
p38 MAPK Pathway
Thrombin signaling and protease-activated receptors
G alpha 13 Pathway
PI3K Pathway
Toll-Like Receptor Pathway
Signaling by FGFR in disease
phosphatidylinositol-mediated signaling
lipid phosphorylation
mammary gland duct morphogenesis
regulation of organ formation
inositol lipid-mediated signaling
Hyperplasia
Cardiomyopathy, Hypertrophic
Signaling events regulated by Ret tyrosine kinase
Bladder cancer
Nuclear Receptors
Signaling by EGFR
positive regulation of protein metabolic process
developmental induction
regulation of DNA biosynthetic process
gliogenesis
tissue morphogenesis
regulation of neurogenesis
Signaling by EGFR in Cancer
DAP12 interactions
Signaling by PDGF
Aldosterone-regulated sodium reabsorption
cell-cell signaling involved in cell fate commitment
positive regulation of glucose transport
regulation of release of cytochrome c from mitochondria
regulation of mitochondrial outer membrane permeabilization involved in apoptotic
signaling pathway
intracellular estrogen receptor signaling pathway
negative regulation of cellular macromolecule biosynthetic process
regulation of mesenchymal cell proliferation
1.16E-03
1.16E-03
1.36E-03
1.36E-03
1.62E-03
1.71E-03
1.71E-03
1.22E-03
1.22E-03
1.22E-03
1.23E-03
1.42E-03
1.42E-03
1.42E-03
1.42E-03
1.42E-03
1.42E-03
1.25E-03
1.26E-03
1.26E-03
1.26E-03
1.26E-03
1.72E-03
1.72E-03
1.47E-03
1.47E-03
1.47E-03
1.47E-03
1.31E-03
1.31E-03
1.31E-03
1.31E-03
1.32E-03
1.32E-03
1.52E-03
1.53E-03
1.53E-03
1.53E-03
1.35E-03
1.35E-03
1.35E-03
1.35E-03
1.35E-03
1.35E-03
1.40E-03
positive regulation of nitric oxide biosynthetic process
protein insertion into membrane
regulation of polysaccharide metabolic process
JNK MAPK Pathway
Interleukin-11 Signaling Pathway
regulation of I-kappaB kinase/NF-kappaB signaling
Focal Adhesion
protein import into nucleus, translocation
Class I PI3K signaling events
Intrinsic Pathway for Apoptosis
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific
DNA binding
type 1 metabotropic glutamate receptor binding
Herpes simplex infection
platelet activation
negative regulation of nucleobase-containing compound metabolic process
immune response-activating cell surface receptor signaling pathway
extrinsic apoptotic signaling pathway
lipid biosynthetic process
negative regulation of I-kappaB kinase/NF-kappaB signaling
regulation of muscle cell apoptotic process
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Selenium Metabolism and Selenoproteins
Interleukin-2 signaling
Hedgehog signaling events mediated by Gli proteins
single-organism organelle organization
IL-7 Signaling Pathway
Regulation of Microtubule Cytoskeleton
negative regulation of nitrogen compound metabolic process
localization of cell
cell motility
cellular response to insulin stimulus
TNF-alpha/NF-kB Signaling Pathway
aging
response to gamma radiation
striated muscle cell differentiation
tube development
stress-activated MAPK cascade
Signaling by FGFR mutants
protein targeting to nucleus
single-organism nuclear import
protein import into nucleus
regulation of growth
epithelial cell morphogenesis
response to cytokine
nuclear import
1.40E-03
1.40E-03
1.40E-03
1.60E-03
1.60E-03
1.43E-03
1.64E-03
1.46E-03
1.67E-03
1.67E-03
2.06E-03
2.06E-03
1.73E-03
1.54E-03
1.54E-03
1.55E-03
1.56E-03
1.57E-03
1.57E-03
1.57E-03
1.81E-03
1.81E-03
1.81E-03
1.81E-03
1.64E-03
1.88E-03
1.88E-03
1.66E-03
1.67E-03
1.67E-03
1.67E-03
1.92E-03
1.68E-03
1.68E-03
1.70E-03
1.70E-03
1.71E-03
1.96E-03
1.72E-03
1.72E-03
1.72E-03
1.72E-03
1.72E-03
1.74E-03
1.77E-03
stress-activated protein kinase signaling cascade
positive regulation of lymphocyte activation
mitochondrial outer membrane permeabilization
Role of phospholipids in phagocytosis
Keratinocyte Differentiation
NGF signalling via TRKA from the plasma membrane
cell cycle process
negative regulation of protein metabolic process
I-kappaB kinase/NF-kappaB signaling
regulation of nervous system development
mesenchymal cell proliferation
muscle cell apoptotic process
positive regulation of mitochondrial membrane permeability involved in apoptotic
process
mitochondrial outer membrane permeabilization involved in programmed cell
death
positive regulation of fibroblast proliferation
FoxO family signaling
spinobulbar muscular atrophy
negative regulation of cellular biosynthetic process
localization within membrane
Notch-mediated HES/HEY network
amb2 Integrin signaling
Type II diabetes mellitus
NOTCH1 Intracellular Domain Regulates Transcription
beta-catenin binding
SMAD binding
receptor binding
T cell apoptotic process
positive regulation of mitochondrial membrane permeability
cell fate commitment
chordate embryonic development
Generic Transcription Pathway
Interleukin-3, 5 and GM-CSF signaling
cellular response to drug
negative regulation of proteolysis
cellular protein localization
developmental process involved in reproduction
embryo development ending in birth or egg hatching
cellular macromolecule localization
neuroblast proliferation
regulation of mitochondrial membrane permeability involved in apoptotic process
Regulation of Androgen receptor activity
chromatin organization
Platelet activation, signaling and aggregation
positive regulation of cellular carbohydrate metabolic process
1.77E-03
1.77E-03
1.77E-03
2.03E-03
2.03E-03
2.04E-03
1.79E-03
1.80E-03
1.80E-03
1.81E-03
1.81E-03
1.81E-03
1.81E-03
1.81E-03
1.81E-03
2.11E-03
2.11E-03
1.85E-03
1.87E-03
2.17E-03
2.17E-03
2.17E-03
2.17E-03
2.68E-03
2.68E-03
2.68E-03
1.94E-03
1.94E-03
1.94E-03
1.94E-03
2.25E-03
2.25E-03
1.99E-03
1.99E-03
1.99E-03
2.01E-03
2.02E-03
2.03E-03
2.04E-03
2.04E-03
2.33E-03
2.05E-03
2.37E-03
2.10E-03
regulation of nitric oxide biosynthetic process
positive regulation of leukocyte activation
PI Metabolism
development of primary sexual characteristics
lipid metabolic process
release of cytochrome c from mitochondria
reproductive process
Id Signaling Pathway
Nuclear Receptor transcription pathway
regulation of kidney development
DNA alkylation
DNA methylation
histone deacetylation
protein import
Endothelins
response to metal ion
mammary gland morphogenesis
regulation of lymphocyte apoptotic process
positive regulation of protein phosphorylation
regulation of DNA metabolic process
positive regulation of cell activation
regulation of protein modification process
regulation of intracellular steroid hormone receptor signaling pathway
regulation of myotube differentiation
Signaling events mediated by focal adhesion kinase
steroid hormone mediated signaling pathway
regulation of glial cell differentiation
response to alcohol
Basal cell carcinoma
ErbB signaling pathway
positive regulation of mitochondrion organization
embryonic digit morphogenesis
response to insulin
viral process
positive regulation of cytokine production
hypomethylation of CpG island
DNA hypomethylation
positive regulation of metanephric cap mesenchymal cell proliferation
cellular response to insulin-like growth factor stimulus
prostate field specification
negative regulation of interleukin-12 biosynthetic process
lactic acid secretion
glycogen cell differentiation involved in embryonic placenta development
prostate induction
male somatic sex determination
activation of prostate induction by androgen receptor signaling pathway
2.10E-03
2.10E-03
2.41E-03
2.12E-03
2.16E-03
2.16E-03
2.18E-03
2.49E-03
2.49E-03
2.21E-03
2.21E-03
2.21E-03
2.21E-03
2.25E-03
2.58E-03
2.26E-03
2.26E-03
2.26E-03
2.26E-03
2.26E-03
2.26E-03
2.29E-03
2.32E-03
2.32E-03
2.67E-03
2.39E-03
2.39E-03
2.40E-03
2.76E-03
2.76E-03
2.44E-03
2.44E-03
2.44E-03
2.44E-03
2.44E-03
2.44E-03
2.44E-03
2.44E-03
2.44E-03
2.44E-03
2.44E-03
2.44E-03
2.44E-03
2.44E-03
2.44E-03
2.44E-03
regulation of metanephric cap mesenchymal cell proliferation
negative regulation of integrin biosynthetic process
myoblast differentiation
nuclear chromatin
Neurotrophic factor-mediated Trk receptor signaling
sex differentiation
organ formation
regulation of mitochondrial membrane permeability
multi-organism cellular process
protein localization to nucleus
branching involved in ureteric bud morphogenesis
regulation of membrane permeability
toll-like receptor 10 signaling pathway
endoderm development
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
p53 pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Notch signaling pathway
B cell activation
lymphocyte differentiation
positive regulation of intracellular signal transduction
nitric oxide biosynthetic process
positive regulation of muscle cell differentiation
POU domain binding
skeletal muscle cell differentiation
toll-like receptor 5 signaling pathway
positive regulation of stem cell proliferation
Wnt Signaling Pathway
leukocyte migration
protein deacetylation
Leukemia
Adenoma
positive regulation of cell migration
epidermis development
steroid binding
modification of morphology or physiology of other organism involved in symbiotic
interaction
DNA methylation or demethylation
ureteric bud morphogenesis
Neoplasm Metastasis
Hypertension
Insulin Resistance
Medulloblastoma
Reifenstein syndrome
Nasopharyngeal carcinoma
Proteus syndrome
2.44E-03
2.44E-03
2.44E-03
3.78E-03
2.85E-03
2.51E-03
2.51E-03
2.51E-03
2.52E-03
2.52E-03
2.57E-03
2.57E-03
2.64E-03
2.64E-03
3.02E-03
3.02E-03
3.02E-03
3.02E-03
3.02E-03
2.67E-03
2.69E-03
2.70E-03
2.70E-03
3.85E-03
2.76E-03
2.76E-03
2.76E-03
3.22E-03
2.83E-03
2.83E-03
3.84E-03
3.84E-03
2.88E-03
2.90E-03
4.10E-03
2.97E-03
2.97E-03
2.97E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
Feminization
ANDROGEN INSENSITIVITY, PARTIAL
Megalencephaly cutis marmorata telangiectatica congenita
BURKITT LYMPHOMA; BL
KERATOSIS, SEBORRHEIC
Bulbo-Spinal Atrophy, X-Linked
Androgen resistance syndrome
Neuroectodermal Tumors
Immunodeficiency 36
Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi
Cowden syndrome 6
X-linked hypospadias 1
Papilloma, Choroid Plexus
Burkitt lymphoma
Mental retardation, autosomal dominant 19
Bulbospinal neuronopathy, X-linked recessive
Balkan Nephropathy
Keratosis, seborrheic
SPINAL AND BULBAR MUSCULAR ATROPHY, X-LINKED 1; SMAX1
Li-Fraumeni syndrome 1
SHORT syndrome
Keratosis, Seborrheic
Basal cell carcinoma, susceptibility to, 7
Cowden syndrome 5
Estrogen resistance
Androgen-Insensitivity Syndrome
PAPILLOMA OF CHOROID PLEXUS
Agammaglobulinemia 7, autosomal recessive
Adrenocortical carcinoma, hereditary
Choroid plexus papilloma
Bulbo-spinal atrophy X-linked
Mouth Neoplasms
regulation of anatomical structure morphogenesis
Validated targets of C-MYC transcriptional repression
IL12-mediated signaling events
positive regulation of cell motility
protein deacylation
toll-like receptor TLR6:TLR2 signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
SREBP signalling
negative regulation of cellular catabolic process
mitochondrion organization
positive regulation of cellular component movement
interspecies interaction between organisms
symbiosis, encompassing mutualism through parasitism
Fas Signaling Pathway
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
4.03E-03
2.98E-03
3.41E-03
3.41E-03
3.00E-03
3.03E-03
3.03E-03
3.03E-03
3.63E-03
3.19E-03
3.19E-03
3.22E-03
3.24E-03
3.24E-03
3.72E-03
HIF-1-alpha transcription factor network
homeostatic process
cellular response to lipid
multicellular organismal reproductive process
negative regulation of intrinsic apoptotic signaling pathway
positive regulation of peptidyl-serine phosphorylation
negative regulation of protein processing
toll-like receptor 9 signaling pathway
positive regulation of type I interferon production
Znf_hrmn_rcpt
NUCLEAR_REC_DBD_2
NUCLEAR_REC_DBD_1
ZnF_C4
zf-C4
Nucl_hrmn_rcpt_lig_bd
Nucl_hrmn_rcpt_lig-bd_core
Hormone_recep
HOLI
p53-like_TF_DNA-bd
Nucl_hormone_rcpt_ligand-bd
Znf_NHR/GATA
Znf_NHR/GATA
P53_TAD
Oestr_rcpt
Oest_recep
Andrgn_rcpt
Myc-LZ
p53_transactivation_domain
Myc-LZ
Androgen_recep
positive regulation of locomotion
glycerolipid metabolic process
AGE/RAGE pathway
TRIF-dependent toll-like receptor signaling pathway
regulation of generation of precursor metabolites and energy
p53-dependent G1/S DNA damage checkpoint
Transcriptional activation of p53 responsive genes
altered p53 signaling pathway
E-cadherin signaling events
estrogen signaling
Transcriptional activation of cell cycle inhibitor p21
Kit Receptor Signaling Pathway
Signaling events mediated by HDAC Class I
DNA damage response
superpathway of inositol phosphate compounds
Skin Neoplasms
3.72E-03
3.29E-03
3.29E-03
3.29E-03
3.29E-03
3.29E-03
3.29E-03
3.29E-03
3.29E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
4.80E-03
3.34E-03
3.34E-03
3.82E-03
3.35E-03
3.35E-03
3.84E-03
3.84E-03
3.84E-03
3.84E-03
3.84E-03
3.84E-03
3.84E-03
3.84E-03
3.84E-03
3.84E-03
4.57E-03
Cytosolic sensors of pathogen-associated DNA
Amphetamine addiction
G1 to S cell cycle control
Ras Pathway
toll-like receptor 2 signaling pathway
regulation of neural precursor cell proliferation
multicellular organism reproduction
spindle
MyD88-independent toll-like receptor signaling pathway
Adipocytokine signaling pathway
nitric oxide metabolic process
T cell differentiation in thymus
oligodendrocyte differentiation
PI3K Cascade
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD4 MH2 Domain Mutants in Cancer
Signaling by TGF-beta Receptor Complex
Loss of Function of TGFBR1 in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR1 LBD Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
Loss of Function of TGFBR2 in Cancer
miRNAs involved in DDR
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by NOTCH1
Signaling by NOTCH1 in Cancer
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Signaling by NOTCH1 HD Domain Mutants in Cancer
FBXW7 Mutants and NOTCH1 in Cancer
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
E2F transcription factor network
Signaling by NOTCH1 PEST Domain Mutants in Cancer
cellular response to alcohol
odontogenesis of dentin-containing tooth
somatodendritic compartment
DNA biosynthetic process
polysaccharide biosynthetic process
skin development
regionalization
3q26.3
5q13.1
regulation of gliogenesis
3.91E-03
3.91E-03
3.91E-03
3.91E-03
3.43E-03
3.52E-03
3.56E-03
5.52E-03
3.59E-03
4.13E-03
3.66E-03
3.66E-03
3.66E-03
4.21E-03
4.21E-03
4.21E-03
4.21E-03
4.21E-03
4.21E-03
4.21E-03
4.21E-03
4.21E-03
4.21E-03
4.21E-03
4.21E-03
4.21E-03
4.21E-03
4.21E-03
4.24E-03
4.24E-03
4.24E-03
4.24E-03
4.24E-03
4.24E-03
4.24E-03
4.24E-03
3.74E-03
3.74E-03
5.84E-03
3.82E-03
3.82E-03
3.87E-03
3.87E-03
1.05E-02
1.05E-02
3.88E-03
regulation of leukocyte apoptotic process
cell fate specification
Pertussis
androgen receptor activity
Krueppel-associated box domain binding
regulation of autophagy
toll-like receptor 3 signaling pathway
MyD88-dependent toll-like receptor signaling pathway
endomembrane system organization
Leishmaniasis
locomotion
establishment of protein localization to mitochondrion
DNA modification
modification of morphology or physiology of other organism
canonical Wnt signaling pathway involved in positive regulation of wound healing
regulation of cell proliferation involved in outflow tract morphogenesis
regulation of heparan sulfate proteoglycan biosynthetic process
renal outer medulla development
negative regulation of macromitophagy
regulation of mitophagy
somatic sex determination
canonical Wnt signaling pathway involved in positive regulation of epithelial to
mesenchymal transition
lateral sprouting involved in mammary gland duct morphogenesis
canonical Wnt signaling pathway involved in positive regulation of cardiac outflow
tract cell proliferation
epicardium-derived cardiac vascular smooth muscle cell differentiation
regulation of macromitophagy
positive regulation of epithelial cell proliferation involved in prostate gland
development
positive regulation of proteoglycan biosynthetic process
metanephric cap development
macromitophagy
metanephric cap morphogenesis
metanephric cap mesenchymal cell proliferation involved in metanephros
development
positive regulation of heparan sulfate proteoglycan biosynthetic process
positive regulation of branching involved in lung morphogenesis
negative regulation of mitophagy
regulation of striated muscle cell differentiation
Cytokine Signaling in Immune system
Apoptosis Modulation and Signaling
G alpha (12/13) signalling events
pancreas development
regulation of carbohydrate biosynthetic process
Fc-gamma receptor signaling pathway involved in phagocytosis
3.88E-03
3.88E-03
4.46E-03
5.49E-03
5.49E-03
3.95E-03
3.95E-03
3.95E-03
3.98E-03
4.57E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.10E-03
4.22E-03
4.89E-03
4.89E-03
4.89E-03
4.30E-03
4.30E-03
4.37E-03
immune response-regulating cell surface receptor signaling pathway involved in
phagocytosis
protein localization to mitochondrion
Neoplasm Recurrence, Local
regulation of lipid transport
Fc-gamma receptor signaling pathway
positive regulation of protein modification process
Phosphatidylinositol signaling system
Validated targets of C-MYC transcriptional activation
regulation of mitochondrion organization
positive regulation of MAPK cascade
Disease
IRS-mediated signalling
Integrin Signaling Pathway
regulation of peptidyl-serine phosphorylation
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Pancreatic Neoplasms
Pilomatrixoma
Sarcoma family syndrome of Li and Fraumeni
PILOMATRIXOMA
ADRENOCORTICAL CARCINOMA, HEREDITARY; ADCC
Pilomatrixoma
LI-FRAUMENI SYNDROME 1; LFS1
Vulvar Lichen Sclerosus
Hypospadias 1, X-Linked
Craniopharyngioma
Fibrous Dysplasia of Bone
Nevus, Epidermal
Urinary bladder cancer
Adrenocortical Carcinoma, Hereditary
Chromosome 17 deletion
Aortic Valve, Calcification of
HYPOSPADIAS 1, X-LINKED; HYSP1
Adenocarcinoma, Clear Cell
Adaptive Immune System
regulation of membrane potential
Fc receptor mediated stimulatory signaling pathway
metanephros development
phosphatidylinositol biosynthetic process
MyD88 dependent cascade initiated on endosome
Toll Like Receptor 7/8 (TLR7/8) Cascade
IRS-related events
p75 NTR receptor-mediated signalling
response to extracellular stimulus
IRS-related events triggered by IGF1R
Salmonella infection
4.37E-03
4.37E-03
6.01E-03
4.45E-03
4.45E-03
4.46E-03
5.12E-03
5.12E-03
4.53E-03
4.55E-03
5.20E-03
5.20E-03
5.20E-03
4.61E-03
5.32E-03
6.34E-03
6.34E-03
6.34E-03
6.34E-03
6.34E-03
6.34E-03
6.34E-03
6.34E-03
6.34E-03
6.34E-03
6.34E-03
6.34E-03
6.34E-03
6.34E-03
6.34E-03
6.34E-03
6.34E-03
6.34E-03
5.41E-03
4.74E-03
4.78E-03
4.78E-03
4.78E-03
5.51E-03
5.51E-03
5.51E-03
5.51E-03
4.88E-03
5.61E-03
5.61E-03
response to cAMP
nucleocytoplasmic transport
estrogen response element binding
androgen binding
regulation of mitotic cell cycle
cellular lipid metabolic process
14q32.32
8q24.21
nuclear transport
regulation of cellular response to stress
response to estradiol
hormone-mediated signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
IGF1R signaling cascade
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Toll Like Receptor 9 (TLR9) Cascade
Genes related to Wnt-mediated signal transduction
chemical homeostasis
Insulin receptor signalling cascade
response to inorganic substance
protein heterodimerization activity
regulation of embryonic development
myotube differentiation
ureteric bud development
mesonephric tubule development
mesonephric epithelium development
cellular response to hypoxia
oligodendrocyte apoptotic process
regulation of centriole-centriole cohesion
positive regulation of determination of dorsal identity
negative regulation of heart induction
cardioblast cell fate commitment
regulation of cardioblast cell fate specification
negative regulation of calcidiol 1-monooxygenase activity
embryonic skeletal limb joint morphogenesis
canonical Wnt signaling pathway involved in positive regulation of apoptotic
process
positive regulation of cellular respiration
positive regulation of mitochondrial membrane potential
negative regulation of cardiac cell fate specification
negative regulation of helicase activity
glial cell fate determination
negative regulation of cardioblast cell fate specification
foregut regionalization
cardioblast cell fate specification
trachea formation
4.96E-03
5.01E-03
7.09E-03
7.09E-03
5.07E-03
5.09E-03
1.39E-02
1.39E-02
5.16E-03
5.19E-03
5.19E-03
5.19E-03
5.19E-03
5.94E-03
5.94E-03
5.94E-03
5.94E-03
5.23E-03
6.06E-03
5.33E-03
7.50E-03
5.47E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
oviduct development
renal inner medulla development
lung induction
positive regulation of ATP biosynthetic process
negative regulation of heart induction by canonical Wnt signaling pathway
prostate epithelial cord elongation
ventricular compact myocardium morphogenesis
tertiary branching involved in mammary gland duct morphogenesis
limb joint morphogenesis
lung field specification
positive regulation of sulfur metabolic process
positive regulation of hyaluronan biosynthetic process
positive regulation of integrin biosynthetic process
toll-like receptor 4 signaling pathway
Xq12
1p34
3p21
4q24
6q25.1
cellular response to decreased oxygen levels
negative regulation of neurogenesis
regulation of type I interferon production
mesonephros development
myelination
ErbB-3 class receptor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
1-phosphatidylinositol-3-kinase regulator activity
estrogen receptor activity
histone deacetylase regulator activity
movement of cell or subcellular component
AKT-mediated inactivation of FOXO1A
nuclear chromosome part
execution phase of apoptosis
ensheathment of neurons
axon ensheathment
type I interferon production
catalytic complex
B cell differentiation
cell-cell junction
beta-catenin-TCF7L2 complex
chromatin
Toll Like Receptor 3 (TLR3) Cascade
MyD88-independent cascade
Beta-catenin
P53
P53_tetramer
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.52E-03
5.55E-03
1.50E-02
1.50E-02
1.50E-02
1.50E-02
1.50E-02
5.64E-03
5.64E-03
5.71E-03
5.71E-03
5.71E-03
8.09E-03
8.09E-03
8.09E-03
8.09E-03
8.09E-03
5.81E-03
6.70E-03
9.14E-03
5.98E-03
5.98E-03
5.98E-03
5.98E-03
9.31E-03
6.08E-03
9.35E-03
9.35E-03
9.35E-03
6.97E-03
6.97E-03
8.88E-03
8.88E-03
8.88E-03
PI3K_p85-bd
p53_tumour_suppressor
p53_deltaN
p53_DNA-bd
Serine/threonine_Kinase_Rac
p53_tetrameristn
PI3K_p85B
p53_tetrameristn
P53
PI3K_p85B
8.88E-03
8.88E-03
8.88E-03
8.88E-03
8.88E-03
8.88E-03
8.88E-03
8.88E-03
8.88E-03
8.88E-03