Nexium Control Heartburn Factsheet Date of preparation: 16th February 2015 NEXIUM CONTROL – SLEEP AND HEARTBURN FACT SHEET Why is heartburn experienced at night? The discomfort of heartburn can often be disruptive to sleep causing a significant impact on people’s quality of life, especially for those who suffer from frequent heartburn where it is occurring two times per week or more.1 Three out of four frequent heartburn sufferers report that heartburn interferes with their sleep, negatively impacting mood and daily function2, and unfortunately many of the mechanisms of sleep can actually make heartburn more likely: - - Lying down: When sitting or standing, gravity helps keep gastric acid in the stomach. When lying flat however, it's much easier for stomach acid to backflow into the oesophagus. Once in the oesophagus, it can stay there for much longer than during the day. Suppressed swallowing: When awake it is a natural reaction to swallow whenever acid begins to reflux. This pushes the acid back down into the stomach. When sleeping however, the swallowing impulse is suppressed. Swallowing saliva (which contains bicarbonate) also helps to neutralise stomach acid. How can night-time heartburn be avoided? Helen Boardman, a pharmacist and lecturer in Pharmacy Practice at Nottingham University, provides ten simple steps that can be taken to reduce the occurrence of night-time heartburn.3 1. Sleep on your left side This is the position that has been found to best reduce acid reflux. Sleeping on the right side also seems to prompt relaxation of the sphincter (the tight ring of muscle connecting the stomach and oesophagus) that normally defends against reflux. 2. Sleep with your upper body elevated Lying down can enable the entry of acid into the oesophagus so many people find their heartburn is worse at night. Try raising the head of your bed approximately 15 cm (6 inches) with some books or blocks. You can also try a wedge pillow. 3. Wait for two to three hours after you eat before going to bed This gives your stomach a chance to process your meal and move it through your digestive system. Your stomach will then be empty and less likely to reflux when you lie down. Eating a smaller and lighter dinner is also a good idea if night time heartburn is a regular annoyance. 4. Watch your weight If you’re overweight, losing excess pounds can help relieve your symptoms. 5. Wear loose-fitting pyjamas Tight clothes, especially near your waist, can put pressure on your stomach, leading to heartburn symptoms. 6. Slow down and relax at dinner time Eating too much, too quickly, can increase heartburn so take your time eating and enjoy mealtimes. Feeling stressed or rushed when you eat can also cause the stomach to produce more stomach acids. 1 Nexium Control Heartburn Factsheet 7. Know your triggers Using a diary to keep track of when heartburn hits can help you understand what’s aggravating your heartburn symptoms. 8. Quit smoking Cigarettes can make heartburn even more painful. Not only can cigarette smoke irritate your food pipe, it also relaxes the oesophageal muscles which keep stomach acid where it belongs. 9. Get moving Taking regular exercise can often help (though certain abdominal exercises like stomach crunches can push acid out of the stomach, causing heartburn). It’s best to wait at least two hours after a meal before exercising. 10. Try a PPI medicine There are a broad range of OTC treatment options available. Antacids and alginates offer temporary relief from symptoms. If you are a frequent heartburn sufferer and want more sustained relief, a proton pump inhibitor (PPI) may help. It targets heartburn at its source by blocking acid production in the stomach and so can provide relief of symptoms through the day and night. Fast facts Night-time heartburn affects 3 out of 4 people who suffer frequent heartburn and reflux2 Many people wake up several times during the night because of pain and burning in their food pipe (oesophagus)4 Interrupted sleep, caused by heartburn can have a significant impact on a person’s quality of life2 Night-time heartburn tends to leave acid in the oesophagus for longer, and therefore may cause more damage than daytime heartburn5 With just one Nexium Control® a day, 8 out of 10 frequent sufferers experienced meaningful improvement in their heartburn symptoms within one week and 4 out of 5 nights were heartburn free 6. Nexium Control® 20mg gastro-resistant tablets for the short-term treatment of reflux symptoms (e.g. heartburn and acid regurgitation) in adults. Active ingredient: Esomeprazole. Always read the leaflet. Nexium Control® is available in packs of 7’s and 14’s at a RRP of £6.99 and £11.99 respectively. It is available in supermarkets and pharmacies nationwide. If symptoms persist or worsen after 14-days treatment, people should see a GP for further advice. ENDS Press enquiries: Email: Issued by: On behalf of: Luke Hopkins (01273 712023) or Laura Cook (01273 712064) lhopkins@thisispegasus.co.uk or lcook@thisispegasus.co.uk Pegasus Pfizer Consumer Healthcare 2 Nexium Control Heartburn Factsheet Notes to editors: When to see a doctor with frequent heartburn Those taking Nexium Control® should see a doctor if symptoms worsen or do not improve after taking the medication for 14 days in a row. In addition those who experience unintentional weight loss, long-term or bloody vomiting, or tarry stools, those who regularly take painkillers or anti-inflammatory drugs and those with a history of gastric or duodenal ulcers, or renal or hepatic impairment should see their doctor. People are also advised to visit a pharmacist or GP if: They are taking any medications listed in the Nexium Control® package leaflet https://www.medicines.org.uk/emc/PIL.29819.latest.pdf They are over the age of 55 and have new or recently change acid reflux symptoms – available: About Pfizer: Working together for a healthier world™ At Pfizer, we apply science and our global resources to improve health and well-being at every stage of life. We strive to set the standard for quality, safety and value in the discovery, development and manufacturing of medicines. Our diversified global health care portfolio includes medicines and vaccines, as well as many of the world’s best-known consumer healthcare products. Every day, Pfizer colleagues work to advance wellness, prevention, treatments and cures that challenge the most feared diseases of our time. Consistent with our responsibility as one of the world’s premier innovative biopharmaceutical companies, we also collaborate with health care providers, governments and local communities to support and expand access to reliable, affordable health care around the world. For more than 150 years, Pfizer has worked to make a difference for all who rely on us. In the UK, Pfizer has its business headquarters in Surrey and is a major supplier of medicines to the NHS. To learn more about our commitments, please visit us at www.pfizer.co.uk. References 1 Data on file. Forbes Consulting Group Usage and Attitude Study 2013. C et al. Arch Intern Med. 2001;161:45-52. 3 Web MD. Tips for sleep without heartburn http://www.webmd.com/heartburn-gerd/features/tips-for-sleep-withoutheartburn. Accessed February 2015.. 4 PubMed Factsheet on Heartburn. 2 Farup www.ncbi.nlm.nih.gov/pubmedhealth/PMH0048152/?report=printable Accessed February 2015. 5 Web MD. The special risks of night-time heartburn. http://www.webmd.boots.com/heartburn-gord/guide/special-risks-of-nighttimeheartburn. Accessed February 2015. 6 Nexium Control Summary of Product Characteristics 3