CURRICULUM VITAE Joseph M. Starobin, Ph.D. 201 West Kemp Rd., Greensboro, NC 27410 e-mail: jmstarob@uncg.edu, ph. (336) 854-8269 EDUCATION 1982 Ph.D. in Mechanics of Fluids, Moscow Physico-Technical Institute 1975 M.Sc. with Honors in Mathematical Physics, Moscow Physico -Technical Institute PROFESSIONAL EXPERIENCE 2010- present Associate Professor, Joint School of Nanoscience and Nanoengineering 2007- 2010 Research Professor, Department of Physics and Astronomy, UNCG Chief Scientist, MSTI 1999- 2007 Executive Vice President, Chief Scientist, Mediwave Star Technology, Inc. (MSTI) 1997- 1999 Visiting Professor, Department of Physics and Astronomy, UNCG 1992- 1997 Research Associate, Duke University Medical Center 1986- 1991 Senior Scientist, Moscow State Pedagogical University, Department of Physics 1982- 1986 Senior Scientist, Moscow Research Institute of Artificial Organs, Department of Biomedical Engineering 1975- 1982 Junior Scientist, Moscow Research Institute of Artificial Organs, Department of Biomedical Engineering RESEARCH GRANTS (TOTAL FUNDING $670,000) PI - National Science Foundation Research Grant, CBET 1342051 PI - Environmental Protection Agency, Contract RFQ-RT-11-00201 CoPI - American Heart Association/Duke University, 10CRP3040018 PI - MSTI Research Grant, Electrophysiology Research Program PI - NIH Research Grants, R43 HL078027-01, R43 HL074501-01A1 PI - Whitaker Foundation Research Grant, No. 96-0161 2013-2015 2011-2013 2010-2013 2007-2009 2004-2006 1996-1999 MEMBERSHIPS IEEE Engineering in Medicine and Biology Society, Member 1998-present TEACHING (TOTAL 6 UNDERGRADUATE AND 6 GRADUATE COURSES) Moscow Physico-Technical Institute and Moscow State Pedagogical University, 1983-1991: Supervision of graduate students and postdoctoral fellows. Lecturing on numerical methods of applied mathematics and biomechanics; Duke University, Department of Biomedical Engineering, 1996: Advanced electrophysiology; UNCG, Department of Physics and Astronomy, 2007-2010 : Introduction to modern physics PHY321, analytical mechanics PHY323, electromagnetism PHY426, modern physics with quantum mechanics PHY421, and supervising individual studies PHY496; JSNN, 2011 – present: Nanophysics NAN603, Non-linear waves in biological media NAN740 JSNN, 2011 – present: Supervision of three graduate students and one postdoctoral fellow JSNN, 2013 – present: Mathematical methods in nanoscience and nanoengineering NAN 605 SUMMARY OF RESEARCH Experimental and theoretical methods of non-invasive diagnostics of coronary artery disease, cardiac ischemia and cardiac arrhythmias. Mathematical modeling and theory of nonlinear waves in excitable media. Nonlinear problems of computational biofluid mechanics. Nonlinear problems of diffraction of electromagnetic waves. MAJOR ACCOMPLISHMENTS Development and implementation of quasi-stationary analysis of QT/RR interval hysteresis and QT/RR interval fluctuations for non-invasive diagnostics of cardiac ischemia and arrhythmias. Organizing and leading interdisciplinary clinical and experimental biomedical studies in collaboration with Cleveland Clinic, Duke Medical Center, Environmental Protection Agency, Brody School of Medicine at East Carolina University, Moses Cone Health System (Greensboro, NC) and UNCG Department of Exercise and Sport Science. Development of theory of vulnerability and rate-dependent restitution in biological excitable media. Development of theory of wavefront-obstacle interactions to explain a mechanism of initiation of cardiac tachyarrhythmias in ischemic cardiac tissue. Mathematical modeling of blood flows in cavities of the artificial heart. Development of theory of diffraction of electromagnetic waves on thin superconducting films. GUEST LECTURES AND VISITING RESEARCH Invited Speaker, Environmental Protection Agency 2011, 2012 Invited Speaker, Departments of Physics and Biomedical Engineering, Duke University 2008 Invited Speaker, Duke University Medical Center 2003, 2005, 2006 Invited Speaker, Cleveland Clinic 2003 – 2006 Invited Speaker, Naval Research Laboratory 1994, 1996,1998 Visiting Researcher, Harvard-MIT Center for Biomedical Engineering 1996, 1998 PUBLICATIONS (TOTAL 71 PAPERS, PATENTS AND BOOK CHAPTERS) PAPERS IN REFEREED JOURNALS 1. V.I.Shumakov, V.M.Zaiko and J.M.Starobin, Numerical modeling of the motion of a disk mitral valve in the left cardiac ventricle. Polymer Mechanics (Sov. Mekhanika Polimerov), 1978, 14(3):407412 2. V.M.Zaiko, J.M.Starobin and A.V.Utkin, Numerical simulation of the movement of a viscous fluid (blood) in a tube with an actively deforming wall. Mechanics of Composite Materials (Sov. Mekhanika Kompozitnykh Materialov), 1979, 15(3):301-306 3. J.M.Starobin and V.M.Zaiko, Numerical study of the flow of a viscous fluid through a deforming tube. Mechanics of Composite Materials, 1979, 15(4):427-431 4. V.M.Zaiko, A.V.Utkin and J.M.Starobin, Numerical modeling of the peristaltic fluid flow in a tube with a wall that deforms according to an harmonic law. Mechanics of Composite Materials, 1979, 15(5):597-600 2 5. J.M.Starobin, Flow of a viscous liquid in the gap between a moving and a fixed sphere at low Reynolds numbers. Fluid Dynamics (Sov. Izvestiya Akademii Nauk, Mekhanika Zhidkosti I Gaza), 1980, 15(6):938-941 6. J.M.Starobin, Flow of a viscous liquid in a bent tube of finite length undergoing deformation. Fluid Dynamics, 1981, (16)2:301-304 7. V.M.Zaiko, J.M.Starobin, A.N.Sharikov and Yu.V.Saakyan, Computerized system of scientific research in artificial heart problems II. Methods and Software. In: Problems of Cybernetics, Implementation of mathematical methods and computers in cardiology and surgery (Sov. Voprosy Kibernetiki, Primenenie Matematicheskikh Metodov I Vychislitel’noy Tekhniki v Kardiologii I Khirurgii), Science, Moscow, 1983, 65-87 (in Russian) 8. J.M.Starobin and V.M.Zaiko, Mathematical modeling of blood flow in cavities with moving boundaries. In: Modern Problems of Biomechanics (Sov. Sovremennye Problemy Biomekhaniki), Riga Academy Press, 1983, 1:59-72 (in Russian) 9. J.M.Starobin and V.M.Zaiko, Numerical modeling of blood flow in the ventricular cavity of the artificial heart. Artificial Organs, 1983, 7(1):122-125 10. J.M.Starobin, S.P.Lupachev, R.V.Dolgopolov and Yu.A.Morov, Analysis of hydrodynamics losses for various types of aortic valves. Mechanics of Composite Materials, 1985 21(3):349-354 11. J.M.Starobin, Comparative analysis of viscous flows in cavities and channels containing axisymmetrical obstacles. Fluid Dynamics, 1988, 23(3):372-377 12. J.M.Starobin, N.V.Soina and S.V.Biryukov, Scattering of electromagnetic waves by a thin conductive strip in a rectangular waveguide. University News, Radio Physics (Sov. Izvestiya Vuzov, Radiofizika), 1988 31(12):1536-1539 13. S.V.Biryukov and J.M.Starobin, Mathematical modeling of electromagnetic wave scattering by resistive strips in a rectangular waveguide. Electrical Engineering: UHF Electronics (Sov. Elektronnaya tekhnika: Seriya 1, Elektronika SVCh), 1989 1(415):28-31 (in Russian) 14. S.V.Biryukov, N.V.Soina and J.M.Starobin, Mathematical modeling of electromagnetic wave scattering on film waveguide bolometers. Electrical Engineering: UHF Electronics, 1989, 2(416):23-25 (in Russian) 15. J.M.Starobin, Electromagnetic wave scattering by metal resistive strips grating on a dielectric substrate. University News, Radio Physics, 1990 33(5):639-642 16. J.M.Starobin, Scattering of electromagnetic waves by a resistive metal strip grating on a dielectric substrate in a rectangular waveguide. J. of Communications Technology and Electronics (Sov. Akademiya Nauk, Radiotekhnika I Elektronika), 1991, 36(7):24-29 17. J.M.Starobin, On the influence of edge effects on the scattering of electromagnetic waves by a thin metallic strip in a rectangular waveguide. J. of Communications Technology and Electronics, 1990 35(14):131-134 18. V.N.Aleksandrov, E.M.Gershenson, G.N.Gol’tsman, J.M.Starobin and V.N.Trifonov, Optimization of the sensitive element of a superconducting film bolometer. Superconductivity (Sov. Sverkhprovodimost’: Fizika, Khimiya, Tekhnika), 1990, part 1, 3(8):1407-1415 19. J.M.Starobin, N.V.Soina, S.V.Biryukov and A.B.Ozherel’ev, Electromagnetic characteristics of the superconducting microwave waveguide elements in the resistive state. Superconductivity, 1990, part 1, 3(10):1611-1619 20. V.N.Polotskii and J.M.Starobin, Maximum efficiency of peristaltic transport, Fluid Dynamics, 1993, 28(2):289-293 21. J.M.Starobin, Y.I.Zilberter and C.F.Starmer, Vulnerability in one-dimensional excitable media. Physica D, 1994, 70:321-341 3 22. Y.I.Zilberter, C.F.Starmer, J.M.Starobin and A.O.Grant, Late Na channels in cardiac cells: The physiological role of background Na channels. Biophysical Journal, 1994, 67:153-160 23. S.V.Biryukov, V.A. Il’in, M.D. Kitaigorodskii, I.A.Semin, N.V.Soina, J.M.Starobin, Absorption of microwave radiation by end-coupled Josephson junctions in the wideband-detection regime. J. of Communications Technology and Electronics, 1994, 34(12):105-107 24. C.F.Starmer, D.N.Romashko, R.S.Reddy, Y.I.Zilberter, J.M.Starobin, A.O.Grant and V.I.Krinsky, Proarrhythmic response to potassium channel blockade: Numerical studies of polymorphic tachyarrhythmias. Circulation, 1995, 92:595-605 25. Y.I.Zilberter, C.F.Starmer, J.M.Starobin and A.O.Grant, Background sodium current and electrical instabilities in cardiac cells. Biophysical Journal, 1995, 68, part 2, A158 26. J.M.Starobin, Y.I.Zilberter, E.M.Rusnak and C.F.Starmer, Wavelet formation in excitable cardiac tissue: The role of wavefront-obstacle interactions in initiating high frequency fibrillatory-like arrhythmias. Biophysical Journal, 1996, 70:581-594 27. J.M.Starobin and C.F.Starmer, Boundary layer analysis of waves propagating in an excitable medium: Medium conditions for wavefront-obstacle separation. Phys. Rev. E, 1996, 54: 430-437 28. C.F.Starmer and J.M.Starobin, Spiral tip movement: The role of the action potential wavelength in polymorphic cardiac arrhythmias. International Journal of Bifurcation and Chaos, 1996, 6, 1909-1923 29. J.M.Starobin and C.F.Starmer, A common mechanism links spiral wave meandering and wavefrontobstacle separation. Phys. Rev. E, 1997, 55: 1193-1196 30. J.M.Starobin, C.F.Starmer and A.J.Starobin, Boundary-layer analysis of a spiral wave core: Spiral core radius and conditions for the tip separation from the core boundary. Phys. Rev. E, 1997, 56: 37573760 31. Y.B.Chernyak, J.M.Starobin and R.J.Cohen, Class of exactly solvable models of excitable media. Phys. Rev. Letters, 1998, 80: 5675-5678 32. Y.B.Chernyak, J.M.Starobin and R.J.Cohen, Where do dispersion curves end? A basic question in theory of excitable media. Phys. Rev. E, 1998, 58: 4108-4111 33. I.B.Schwartz, I.Triandaf, J.M.Starobin and Y.B.Chernyak, Origin of quasiperiodic dynamics in excitable media. Phys. Rev. E, 2000, 61: 7208 – 7211 34. M.S.Lauer, C.E.Pothier, Y.B.Chernyak, R.Brunken, M.Lieber, C.Apperson-Hansen and J.M.Starobin, Exercise-induced QT/RR interval hysteresis as a predictor of myocardial ischemia. J. of Electrocardiology, 2006, 39: 315-323 35. J.M.Starobin, W.E. Cascio, A.H.Goldfarb, V.Varadarajan, A.J.Starobin, C.P.Danford and T.A.Johnson, Identifying coronary flow reduction and ischemia using quasi-stationary QT/RR interval hysteresis measurements. J. of Electrocardiology, 2007, 40: S91 – S96 36. V.N.Polotski , V.Varadarajan, A.J.Starobin, C.P.Danford , W.E. Cascio, T.A.Johnson, J.M.Starobin, Relation between cardiac restitution and flow limitation in an experimental model of coronary artery disease. J. of Electrocardiology, 2008, 41: 646 37. J.M.Starobin, C.P.Danford, V.Varadarajan, A.J.Starobin, V.N.Polotski, Critical scale of propagation influences dynamics of waves in a model of excitable medium. Nonlinear Biomedical Physics, 2009, 3:4 38. C.P.Danford, V.Varadarajan, A.J.Starobin, V.N.Polotski, J.M.Starobin, Cardiac restitution and electrographic stress testing. J. of Electrocardiology, 2009, 42: 619 39. J.M.Starobin, V.Varadarajan, Entrainment of marginally stable excitation waves by spatially extended sub-threshold periodic forcing. Nonlinear Biomedical Physics, 2011, 5:8 40. S.A.Vance, E.Zeidan, L.B.Williams, J.M.Starobin, M.G.Sandros, An easy method to synthesize carbon-coated quantum dots. Nano LIFE, 2013, 3: 1340006(1-6) 4 41. J.M.Starobin, V.Varadarajan, H.E.Reilly, J.Brinkley, W. Krassowska Neu, S.F.Idriss, N. Peterson, E. Kyritsis, A. Movahed, and W.E.Cascio QT/RR interval hysteresis and stability of propagation reserve in the heart: Pilot study in revascularized patients, ISRN Cardiology Research and Practice (submitted), 2013 BOOK CHAPTERS AND REVIEW ARTICLES 1. C.F.Starmer and J.M.Starobin, Antiarrhythmic and proarrhythmic mechanisms in cardiac tissue: Linking spiral waves, reentrant arrhythmias and electrocardiographic patterns. In: Spooner P.M., Joyner R.W., Jalife J. (eds.) Discontinuous Conduction in the Heart. Futura Publishing Company, Armonk, NY, 1997, pp.321-394 2. Y.B.Chernyak and J.M.Starobin, Characteristic and critical excitation length scales in 1D and 2D simulations of reentrant cardiac arrhythmias using simple two-variable models. Critical Reviews in Biomedical Engineering, 1999, 27: 359 – 414 3. J.M. Starobin, Yuri B. Chernyak, A role of a critical excitation length scale in dynamics of reentrant cardiac arrhythmias, Herz Schrittmachertherapie & Electro-physiologie, 1999, 10(2): 119-136 4. J.M.Starobin, S.S.Gilani, S.Aravamudhan Applications of micro/nanotechnology to design and control of neural interfaces. In: Kelkar A. (ed.) Advances in Nanoscience and Nanoengineering.CRC Press, 2013 (submitted) PATENTS 1. J.M.Starobin, V.M.Zaiko Method of testing the cardio-vascular system during cardio-surgical operations, 1986, USSR patent No. 1263223 2. S.P.Dolgopolov, G.V.Morov, J.M.Starobin Hydrodynamic device for testing the heart artificial valves, 1986, USSR patent No. 1299586 3. J.M.Starobin, Y.B.Chernyak Method and system for evaluating cardiac ischemia, US Patent No. 6,361,503, 2002 4. J.M.Starobin, Y.B.Chernyak Method and system for evaluating cardiac ischemia, US Patent No. 6,663,572, 2003 5. J.M.Starobin, Y.B.Chernyak Method and system for evaluating cardiac ischemia with RR-interval data sets and pulse or blood pressure monitoring, US Patent No. 6,656,126, 2003 6. J.M.Starobin, Y.B.Chernyak Method and system for evaluating cardiac ischemia with RR-interval data sets, US Patent No.6,652,467, 2003 7. J.M.Starobin, Y.B.Chernyak Method and system for evaluating cardiac ischemia with an abrupt stop exercise protocol, US Patent No. 6,648,830, 2003 8. J.M.Starobin, Y.B.Chernyak Method and system for evaluating and locating cardiac ischemia, US Patent No. 6,648,829, 2003 9. J.M.Starobin, Y.B.Chernyak Method and system for evaluating cardiac ischemia with heart rate feedback, US Patent No.6,768,919, 2004 10. J.M.Starobin, Y.B.Chernyak Method and system for evaluating cardiac ischemia with an exercise protocol, US Patent No.7,104,961, 2006 11. J.M.Starobin, Y.B.Chernyak Method and system for evaluating arrhythmia risk with QT-RR interval data sets, US Patent No.7,123,953, 2006 12. J. M. Starobin, V. Varadarajan, Method and system of stimulation of nerve tissue with a sequence of spatially distributed resonant sub-threshold electrical stimuli, U.S. Patent Application No. 61/424,758, 2010 (pending) 5 13. J.M. Starobin, V. Varadarajan, W. Krassowska Neu, S.F. Idriss, Method and system for evaluating stability of propagation reserve, U.S. Patent Application No. 61/506,289, 2011 (pending) PAPERS IN REFEREED CONFERENCE PROCEEDINGS 1.V.M.Zaiko and J.M.Starobin, Numerical study of viscous flow in deforming tube. In: Proceedings of the 7th International Congress of Biomechanics, Baltimore, University Park Press, 1979, vol. 3a, 609616 2. J.M.Starobin, Y.I.Zilberter and C.F.Starmer, Unexcitable zones as a source of spiral waves initiation and cardiac arrhythmias. In: Proceedings of the 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Baltimore, 1994 vol.16, part 1, 5-6 3. J.M.Starobin and V.N.Polotskii, About the maximum efficiency of peristaltic transport. In: Proceedings of the Second World Congress of Biomechanics, Amsterdam, The Netherlands, 1994, vol.1, 124 4. J.M.Starobin, Comparative analysis of viscous flows in cavities and channels containing the obstacles. In: Proceedings of the Second World Congress of Biomechanics, Amsterdam, The Netherlands, 1994, vol.1, 119 5. J.M.Starobin, Y.I.Zilberter and C.F.Starmer, Conditions for wavefront separation from an unexcitable obstacle in cardiac tissue of low excitability. In: Proceedings of the 17th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Montreal, Canada, September 2023, 1995 6. J.M.Starobin and C.F.Starmer, Spiral wave meandering, wavefront-obstacle separation and cardiac arrhythmias. In: Proceedings of International Conference “Computers in Cardiology 96”, Indianapolis, Indiana, USA, September 8-11, IEEE Inc., 1996, 233-236 7. J.M.Starobin, J.M.Wharton and G.S.Shander, Comparative analysis of polymorphic ventricular tachyarrhythmias and fibrillation: Clinical observations and numerical experiments. In: Proceedings of International Conference “Computers in Cardiology 98”, Cleveland, USA, September 13-16, vol. 1, 2528, IEEE Inc., 1998 8. J.M.Starobin, Y.B. Chernyak and R.J.Cohen, Tachyarrhythmias and electrical instabilities in cardiac tissue. In: Proceedings of International Conference “Computers in Cardiology 98”, Cleveland, USA, September 13-16, vol.1, 365-368, IEEE Inc., 1998 9. A.H.Goldfarb, M.J.McKenzie, T.A.Johnson, W.E.Cascio, D. Aycock, J.M.Starobin, Production of protein carbonyls, IL-6 and creatine kinase in paced hearts during regional cardiac flow reduction. In: Proceedings of American College of Sports Medicine Conference, 2006 10. Starobin, J. M., Varadarajan, V., Danford, C. P. , Starobin, A. J. , Polotski, V. N. , T.A.Johnson, W.E.Cascio, (2009). Using a theoretical model of cardiac tissue to assess coronary flow reduction. In: Proceedings of 8th International Congress on Coronary Artery Disease, 2009, Prague, Czech Republic, Medimond S.R.L., 371-375. 11. V. Varadarajan, V.N. Polotski, C.P. Danford, A.J. Starobin, J.M. Starobin, (2009). Assessing QTRR interval hysteresis in 12-lead electrocardiograms. In: Proceedings Computers in Cardiology, 2009, Park City, UT, USA, 36, 273-276. 12. J.M. Starobin, V. Varadarajan, V. N.Polotski, Evaluation of restitution slopes using a quasistationary exercise protocol. In: Proceedings Computing in Cardiology, 2010, Belfast, Ireland, 37, 777780. 13. J.M. Starobin, V. Varadarajan, S. Aravamudhan, High-density peripheral nerve resonant stimulation system. In: Proceedings BMES - Biomedical Engineering Society Annual Meeting, Hartford, Connecticut, October 2011 6 14. S.F. Idriss, W. Krassowska Neu, V. Varadarajan, T. Antonijevic, S.S. Gilani, J.M.Starobin, Feasibility of non-invasive determination of the stability of propagation reserve in patients. In: Proceedings Computing in Cardiology, 2012, Krakow, Poland, 39, 353-356. 7