NSF Funded National Synthesis Centers Judith A. Verbeke The NSF funded National Synthesis Centers play a critical role in organizing and synthesizing biological knowledge that is useful to researchers, policy makers, government agencies, educators, and society. They develop new tools and standards for management of biological information and meta-information, support data analysis capabilities with broad utility across the biological sciences, host workshops that bring together scientists from a variety of disciplines, and host and curate databases. Synthesis Centers do not support the collection of new data; they add value to data already collected. The Directorate for Biological Sciences at NSF pioneered Synthesis Centers more than 15 years ago in response to community requests for a Center that would bring scientists together to synthesize the growing body of data in the field of ecology. The vision was to create a Center that would address new questions, pose new research approaches, and advance existing fields in new directions through the process of synthesis. The specific questions or problems to be addressed were not to be defined by the Center, or specified in the initiating proposal, but rather be proposed by the research community and thus to change over time. Over its 15 years of operation, this Center (the National Center for Ecological Analysis and Synthesis, or NCEAS; http://www.ncceas.ucsb.edu ) facilitated synthesis to answer scores of specific questions, advocating a new culture of collaboration in the field of ecology. Since its inception in 1995, NCEAS has hosted more than 5,000 individuals and supported more than 500 projects; products have included both high volume and high profile publications, stellar postdoctoral training in synthesis, and – to a lesser extent – educational and outreach materials. NSF/BIO now supports a portfolio of National Synthesis Centers that realize synthesis in different ways and focus on different disciplines and approaches. These Centers capitalize on economies of scale, cutting edge cyberinfrastructure, and foster innovation in ways not possible by individual researchers. The research conducted by scientists who participate in these Centers has become increasingly collaborative, interdisciplinary, and international. New social challenges have arisen around how scientists work together across disciplines, institutions, and geographic and political boundaries – and how we measure the impact of these shifts. As a result, the notion of synthesis as advanced by Centers has changed considerably since NCEAS’ inception. The National Evolutionary Synthesis Center (NESCENT; http://www.nescent.org ) promotes the synthesis of information, concepts and knowledge to address significant, emerging, or novel questions in evolutionary science and its applications. This Center’s science, informatics, and education and outreach programs serve the science community, educators and the general public. NESCENT science includes a broad portfolio that spans a wide range of organisms, habitats, methods, and disciplines. NESCENT’s education and outreach activities include Darwin Day Roadshows, teacher training workshops, and an evolution film festival. The core NSF funding to NESCENT has enabled the Center to initiate or participate in additional externally funded cyberinfrastructure projects that are aligned with the Center’s mission. The National Institute for Mathematical and Biological Synthesis (NIMBIOS; http://www.nimbios.org ) supports creative solutions to complex problems at the interface between mathematics and biology. NIMBIOS enables scientific advances with high impact in areas as diverse as agriculture, the environment, health, and national security. This Center includes education programs aimed at the mathematics/biology interface, thereby building the capacity of mathematically competent, biologically knowledgeable, and computationally adept researchers needed to address the vast array of challenging questions in this century of biology. Education and outreach occurs at many levels, including K-12, research experiences for undergraduates, partnerships with minority-serving institutions, postdoctoral training, and education of the general public. The iPlant Collaborative (iPlant; http://www.iplantcollaborative.org ) provides cyberinfrastructure to enable new conceptual advances in plant sciences through integrative, computational thinking. iPlant focuses on grand challenge questions in the plant sciences, including innovative approaches to education, outreach, and the study of social networks. This Center involves plant biologists, computer and information scientists and engineers, as well as experts from other disciplines who all work together in integrated teams. The cyberinfrastructure created by iPlant provides access to worldclass physical infrastructure as well as services that promote interactions that advance the use of computational thinking in plant biology. The iPlant cyberinfrastructure framework includes hardware, software, and support for the multidisciplinary teams. The Socio-Environmental Synthesis Center (SESYNC; http://www.sesync.org ) uses synthetic approaches to advance the frontiers of scientific understanding of environmental complexity in order to anticipate and manage environmental challenges. SESYNC is dedicated to creating synthetic, actionable science related to the structure, functioning, and sustainability of socio-environmental systems. The Center defines “actionable science” as scholarship that has the potential to inform government, business, and household decisions; improve the design and/or implementation of public policies; influence public or private sector strategies, planning and behaviors that affect the environment. Workshops sponsored by the Center engage philosophers, sociologists, political scientists, psychologists, anthropologists, environmental biologists, and policy makers to integrate broad disciplines from the outset and to set precedence for all subsequent activities.