IMPERIAL COLLEGE LONDON
JOB DESCRIPTION
Job Title:
Research Associate (SM144-10 c)
Department:
Surgery and Cancer
Division:
Cancer
Job Family/Level:
Research and Education Family, Level B
Salary Range:
£26,720 - £34,920 per annum
Responsible to:
Professor R Charles Coombes
Contract:
Full time for a fixed-term of up to 3 years in the first instance
Location:
Hammersmith Hospital campus, East Acton
Purpose:
The Imperial College London Cancer Research UK Cancer Centre has been
established to create an internationally leading Centre focused on cancer and will
support high quality multidisciplinary science. The Centre aims to better develop our
understanding of cancer, existing therapies and to develop new therapies and
biomarkers that will make a significant impact on patient care in the short to medium
term and will also train the next generation of cancer scientists.
This research activity is based within a five star research institution equipped with the
latest technologies and facilities. The post is available from 1st October 2010 as part
of a new Cancer Research UK funded 5-year programme grant based in the Cancer
Centre, to carry out research on mechanisms of breast cancer progression and the
development of new therapeutic agents. The successful applicant will work with
Professor Charles Coombes in a multi-disciplinary team of biochemists, cell
biologists, molecular biologists, medicinal chemists and oncologists.
Project:
The post-holder will join a team of biologists, chemists and oncologists to study notch
and gamma secretase as targets for the treatment of breast and other cancers. The
project arises out of our recent work that has identified novel potent and selective
notch inhibitors. The project will involve compound screening and evaluation as
cancer therapeutics, development of biomarkers, investigation of the mechanisms of
inhibitor action and associated pharmacological development. The post-holder will be
expected to help co-ordinate the multidisciplinary effort on this project and work
towards developing an independent programme of research.
Duties:
The post holder will be required to carry out the following duties:
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Timely execution of the research project.
To work independently but also liaise with other team members pursuing related
research.
To participate in research meetings, contributing to the presentation of results to
the group, and in internal seminars.
To prepare and present data from research in national and international
conferences.
Contribute to the preparation of grant reports and scientific publications as
required.
To support and attend research and educational activities, as appropriate.
To support the senior academic staff of the group in their research work.
Provide guidance to staff and students.
Compliance with College policies, including financial regulations, equal
opportunities, promoting race equality, health and safety policy, information
systems security policy, intellectual property rights and register of interest
policies.
Compliance with Health and Safety Guidelines within the Laboratory.
Compliance with ethical and CBS regulations.
Job descriptions cannot be exhaustive and so the post holder may be required
to undertake other duties, which are broadly in line with the above key
responsibilities.
The post holder is expected to observe and comply with all College policies
and regulations, for example Health and Safety, Data Protection etc.
Imperial College is committed to equality of opportunity and to eliminating
discrimination. All employees are expected to adhere to the principles set out
in our Equal Opportunities in Employment Policy, Promoting Race Equality
Policy and Disability Policy and all other relevant guidance/practice
frameworks.
PERSON SPECIFICATION
Qualifications
Essential
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The successful candidate will hold a PhD or equivalent qualification in
biochemistry, pharmacology or a related subject.
Experience and Knowledge
Essential
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Evidence of previous work in this area of research and/or associated techniques
applicable to the project.
Proven experience and or knowledge of drug development.
Desirable
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Experience with in vivo models and pharmacological assays involved in drug
development.
Experience in notch signaling.
Experience and familiarity of ChIP sequencing, Bioinformatics and drug discovery
Skills and Abilities
Essential
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Excellent interpersonal skills.
Proven time management and organisational skills.
Proven ability to work on own initiative and function as part of a team.
Excellent verbal communication skills and ability to deal with a wide range of
people.
Excellent written communication skills and ability to write clearly and succinctly
for publication.
Proven ability to prioritise own workload to meet deadlines whilst maintaining a
high degree of accuracy.
Desirable
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Ability to present papers, generate progress reports, publish papers.
Ability to use electronic databases and reference sources.
APPLICATION GUIDANCE
Please read the person specification carefully and describe, as part of your
application, how much you feel you meet each of the criteria.
If you attach a CV it should include the following information:
Applicant’s full name, private address and private telephone number
A confidential fax number and e-mail address, where possible
Degrees (including University and dates)
Past and present posts
List of publications
Brief description of future research plans
Names, addresses and, email, fax numbers, of three referees.
Thank you for your interest in this post. We look forward to receiving your application.