Chapter 42, Part I (Circulation) Study Guide Vertebrate Hearts Fish # Atria; # Ventricles Total Chambers Frog 1; 1 Bird 2; 1 2; 2 Mammal 2; 2 2 3; Ventricle splits 4 4 blood to both circuits Circuits Present; Gill circulation; Pulmocutaneous; Pulmonary; Pulmonary; types systemic systemic systemic systemic circulation circulation Mixing of O2 No Yes; Double No No rich/poor blood circulation More heart chambers allows higher metabolic rate because of less mixing of oxygenated and deoxygenated1 blood, more powerful heart, ability to pump more blood 2 chambered heart limits metabolic rate because heart must pump through 2 capillary beds, pressure reduced at each bed; 3 & 4 chambered hearts pump heart → capillary bed → heart → bed → heart Ridge in 3 chambered heart diverts most deoxygenated blood to lungs ( blood doesn’t mix completely) Open vs. Closed Circulatory Systems Open Blood = interstitial fluid (Hemolymph) Blood bathes organs directly via sinuses Ex. Insects, arthropods Closed Blood is separate from interstitial fluid Heart pumps blood into large vessels that branch into smaller ones Diffusion exchanges materials through smaller vessels Ex. Earthworms, squids, octopuses, vertebrates Both Blood Blood vessels Heart Blood Vessels: Arteries, Veins, Capillaries Arteries Direction of blood flow Away from heart Location in body Carries towards organs General structure; Endothelium (inner thickness lining), smooth muscle, connective tissue Thicker middle/outer layers than veins (higher pressure) High, uneven pressure Elastic? Yes Function in circ. Carry blood to organs system 1 Veins Towards heart Carries away from organs Endothelium (inner lining), smooth muscle, connective tissue Low, even pressure Has valves to prevent backflow into capillary beds Yes Return blood to heart by skeletal muscle action Blood is never truly “de-oxygenated”, this term is used to describe poorly oxygenated blood Capillaries Connects arteries & veins Within organs Endothelium (inner lining), basement membrane very narrow No Diffusion of substances to/from organs Components of Blood: WBC, RBC, Platelets, Plasma WBC (leukocytes) RBC (erythrocytes) Platelets Function(s) Defense; fight infections Where produced How/why regenerated Transport oxygen Clotting ———— Bone marrow; ribs, vertebrae, breast bone, pelvis ———— Plasma Osmotic balance pH buffering (7.4) clotting defense Mostly water (see below) Pluripotent stem cells →Myeloid stem cells Only last 3-4 mos.; Pluripotent stem cells →Myeloid stem cells; erythropoietin stimulates RBC production Cytoplasmic fragments of cells in bone marrow Kidneys regulate concentration of ions/water < 1% of all blood 42% of all blood 3% of all blood 55% of all blood No Yes, more space for hemoglobin Yes b/c fragments of cells Yes b/c not cells % composition by volume Cell organelles lacking? Key Terms Circulation ABO blood groups Genetically determined classes of human blood that are based on the presence or absence of carbohydrates A and B on the surface of red blood cells. The ABO blood group phenotypes, also called blood types, are A, B, AB, and O. acetylcholine One of the most common neurotransmitters; functions by binding to receptors and altering the permeability of the postsynaptic membrane to specific ions, either depolarizing or hyperpolarizing the membrane. adrenaline arteriole arteriosclerosis artery Hormone, aka epinephrine; produced in respone to stress; increases HR A vessel that conveys blood between an artery and a capillary bed. A cardiovascular disease caused by the formation of hard plaques within the arteries. A vessel that carries blood away from the heart to organs throughout the body. Atrioventricular A region of specialized muscle tissue between the right atrium and right ventricle. It (AV) node generates electrical impulses that primarily cause the ventricles to contract. basophils cardiac cycle A circulating leukocyte that produces histamine. The alternating contractions and relaxations of the heart. countercurrent exchange The opposite flow of adjacent fluids that maximizes transfer rates; for example, blood in the gills flows in the opposite direction in which water passes over the gills, maximizing oxygen uptake and carbon dioxide loss. diastole The stage of the heart cycle in which the heart muscle is relaxed, allowing the chambers to fill with blood. dissociation A chart showing the relative amounts of oxygen bound to hemoglobin when the curve pigment is exposed to solutions varying in their partial pressure of dissolved oxygen. erythrocytes A red blood cell; contains hemoglobin, which functions in transporting oxygen in the circulatory system. fibrin The activated form of the blood-clotting protein fibrinogen, which aggregates into threads that form the fabric of the clot. fibrinogen The inactive form of the plasma protein that is converted to the active form fibrin, which aggregates into threads that form the framework of a blood clot. hemoglobin An iron-containing protein in red blood cells that reversibly binds oxygen. hemolymph In invertebrates with an open circulatory system, the body fluid that bathes tissues. hypertension High blood pressure interstitial fluid lymphocytes medulla The internal environment of vertebrates, consisting of the fluid filling the spaces between cells. A white blood cell. The lymphocytes that complete their development in the bone marrow are called B cells, and those that mature in the thymus are called T cells. Also called the medulla oblongata, it is the lowest part of the vertebrate brain; a swelling of the hindbrain dorsal to the anterior spinal cord that controls autonomic, homeostatic functions, including breathing, heart and blood vessel activity, swallowing, digestion, and vomiting. monocytes An agranular leukocyte that is able to migrate into tissues and transform into a macrophage. myoglobin An oxygen-storing, pigmented protein in muscle cells. neutrophils The most abundant type of leukocyte. Neutrophils tend to self-destruct as they destroy foreign invaders, limiting their life span to but a few days. peripheral resistance plasma The impedance of blood flow by the arterioles. The liquid matrix of blood in which the cells are suspended. platelets A small enucleated blood cell important in blood clotting; derived from large cells in the bone marrow. Rh factor A category of erythrocyte antigen that generates antibodies of the IgG class. semilunar valve A valve located at the two exits of the heart, where the aorta leaves the left ventricle and the pulmonary artery leaves the right ventricle. sinatrial (SA) node The pacemaker of the heart, located in the wall of the right atrium. At the base of the wall separating the two atria is another patch of nodal tissue called the atrioventricular node (AV). systemic circulation The branch of the circulatory system that supplies all body organs and then returns oxygen-poor blood to the right atrium via the veins. systole The stage of the heart cycle in which the heart muscle contracts and the chambers pump blood. vein venule A vessel that returns blood to the heart. A vessel that conveys blood between a capillary bed and a vein.